Respiratory systemDevelopment & anomalies
Maj Rishi Pokhrel, MDAnatomy
NAIHSwww.slideshare.net
What triggers labor of childbirth?
Respiratory diverticulum
25 Day embryo
Partition of tubes
Larynx
6 week 12 week
4th arch: superior laryngeal N 6th arch: superior laryngeal N
Trachea, bronchi & lungs
Prenatal: 17 generationsPostnatal: 6 generations
• Epithelium: endoderm• Cartilage, muscles, connective tissue:
mesoderm
Pleural cavity
Maturation of lungs
DEVELOPMENT OF DIAPHRAGM
Defects in partition of foregutesophageal atresia / Tracheo-esophagal fistula
Total Incidence: 1/3000
90%4%4%
1% 1%
VACTERAL association
• V: Vertebral anomalies• A: Anal atresia• C: cardiac defects• E: esophageal atresia• R: renal anomalies• L: limb defects
• Respiratory distress syndrome / hyaline membrane disease
• Ectopic lung lobes• Congenital cysts of lungs
Assignment
• Poly-hydraminos?• Oligo-hydraminos?