G3 Bioreactor Control Platform
Flexible and reliable bioreactor control enabled by SmartPart intelligence
Data File #F802-DST-001-Rev2
Scalablity Transfer any process from 0.5 L to 2000 L
Modularity Configure to control most any bioreactor size or brand
Adaptability Plug-and-play SmartParts and 3rd party peripherals
ROI Increase productivity and minimize down-time
Totality Optimize globally through vessel harmonization
SmartControllers | Bioreactor Controllers
Finesse Smart Controllers
Universal ControlFinesse has designed its third-generation
SmartController bioreactor hardware to
be highly configurable and easily adapted
to both cell culture and fermentation
applications. By leveraging SmartParts
components, all G3 controllers have the
capability and flexibility required to optimize
any process, whether in the laboratory
or in a cGMP-compliant manufacturing
plant. The G3 control platform incorporates
innovative features that enhance the
productivity, quality, and reproducibility of
batch, fed batch, or perfusion processes.
Upstream process scale-up strategies need
not be limited to one bioreactor vendor.
G3 SmartControllers have been designed
to easily connect to most brands of glass,
single-use, or rocker bioreactors without
sacrificing the quality of control. G3 systems
are modular in design, so the hardware
configuration can easily evolve with any
process, and integrate additional functionality
and third-party peripherals as needed.
Compatible Bioreactor Vessels
Controller Bioreactor Type Manufacturer Working Volume (L)
G3Lab™ Universal
Glass Finesse 1, 2, 5, 10
Applikon 0.9, 1.7, 2.7, 3.4, 5.4, 12, 16
Sartorius STR® 1, 2, 5, 10
New Brunswick Scientific
1, 2.2, 5.6, 10.5
Single-Use Millipore Mobius CellReady™
2.4
New Brunswick Scientific
3.4, 10.5, 45
Xcellerex XDR™ 10
Rocker Finesse 10, 20, 50
GE Wave™ 10, 20, 50
G3Lite™ Single-Use Thermo Scientific HyPerforma™ SUB
50, 100, 250, 500, 1000, 2000
Millipore Mobius CellReady™
50, 200
G3Pro™ G3Flex™
Single-Use Thermo Scientific HyPerforma™ SUB
50, 100, 250, 500, 1000, 2000
Xcellerex XDR™ 50, 200, 500, 1000, 2000
ATMI PadReactor™ 25, 50, 300, 600, 1350
Millipore Mobius CellReady™
50, 200
Sartorius STR® 50, 200, 500, 1000
ASI™ 50, 300
SmartControllers | Bioreactor Controllers
G3Lab Universal The G3Lab Universal controls bench-top bioreactors (single-use
or reusable up to 20 L) and rockers (up to 50 L). The system consists of a
utility tower and a TruFlow gas manifold. G3Lab Universal controllers minimize
footprint while maximizing process flexibility. By leveraging SmartParts across
the range of configurations, G3Lab Universal systems enable fully traceable
cGMP process scale-up or scale-down in the laboratory environment.
G3Lite G3Lite systems control single-use Thermo Scientific HyPerforma™ SUB
(50 L to 2000 L) and Millipore Mobius CellReady™ (50 L to 200 L) bioreactors.
The system consists of a control tower that leverages SmartPart
transmitters, MFC’s, and pumps for superior performance. G3Lite
controllers are fully self-contained, movable units that can be operated
singly or networked. They are engineered to optimize capital cost without
sacrificing the option of use in cGMP-certified production facilities.
G3Pro Universal The G3Pro Universal controls single-use bioreactors (25 L to 2000 L)
and mixers (50 L to 2000 L). The system consists of a utility tower, a
TruFlow gas manifold, and a Vessel Adaptor Box specific to the vessel
being controlled. SmartPart transmitters and pumps are used for
maximum flexibility. G3Pro controllers can be mounted on fixed skids
or movable carts, can be quickly reconfigured or expanded for multi-
product applications, and have complete cGMP documentation.
G3Flex G3Flex systems are custom designed to run unique or highly complex
processes in challenging environments (e.g., BSL-3).G3Flex systems can
be fully integrated or modular. A typical system will include a utility tower,
pump tower, and gas manifold, with optional accessories for perfusion,
harvest, or gravimetric feeding. G3Flex systems can be used with bioreactors
of any type or size in R&D, PD, pilot, and production applications.
4 Modular Configurations
R&D // PD Production
R&D // PD Production
Bespoke control for any process
R&D // PD Production
SmartControllers | Bioreactor Controllers
SmartParts make your process excellent.
SmartParts are intelligent, plug-and-play
hardware building blocks for measurement
and control of bioprocesses. Designed for
applications ranging from R&D to cGMP-
compliant manufacturing processes, SmartParts
are hot-pluggable, have built-in diagnostics
and factory calibrations, can be auto-detected
by the network, and provide optimized local
control of the given bioprocess function.
Supercharge your controller. Be SMART.Finesse’s third-generation SmartControllers are
driven by SmartParts. These G3 systems are
easily configured to control any size or brand
of upstream vessel. They enhance bioprocess
reproducibility by exploiting the local control
capability of each SmartPart, and increase
productivity by decreasing the loading on
the primary control and data networks.
TruSens Blade Transmitter Digital signal transmission for sterilizable
pH / DO and temperature sensors
TruFluor pH or DO Blade Transmitter Digital signal transmission for
single-use pH or DO optical sensors
TruTorr Blade Transmitter Digital signal transmission for
single-use pressure sensors
SmartScale Blade Transmitter Digital signal transmission
for load cells and scales
SmartPumps Digital control of Watson Marlow®
Series 114 / 313 / 520 / 620 pump heads
TruFlow Gas Manifold Digital control of mass flow controllers
and associated solenoids
SmartMotors Digital control of motors for bioreactor
agitators and rockers
SmartParts = Transmitters + Actuators
SmartControllers | Bioreactor Controllers
G3Lab UniversalSPECIFICATIONS
Utility Tower Dimensions (H × W × D) 438.4 x 240 x 482.6 mm (17.3 x 9.5 x 19 in)
Enclosure Rating NEMA2
Operating Temperature 5°C to 40°C (41°F to 104°F)
Storage Temperature -40°C to 70°C (-40°F to 158°F)
Relative Humidity 5% to 95% Non-Condensing
Certifications Tested and verified as meeting CE standards EN-60101 and EN 61325
Weight / Shipping Weight 14 kg / 21.4 kg (31 lbs / 47 lbs)
Agitation
Finesse SmartMotor Controller – Glass Vessel Agitator or Rocker
Connection to Vessel Adapter Box – Thermo Scientific HyPerforma™ SUB Only
Serial Port Connection to GE Wave™ Rocker – EHT Model Only
pH (Up to 2 Inputs)TruSens Transmitter (Electrochemical Sensors) or TruFluor pH Transmitter (Rocker, Single-Use Vessel)
DO (Up to 2 Inputs)TruSens Transmitter (Electrochemical Sensors) or TruFluor DO Transmitter (Rocker, Single-Use Vessel)
Temperature TruSens Transmitter (RTD) or TruFluor (Rocker)
Foam Level Conductivity Input
Liquid Control Four (4) Variable-Speed Peristaltic SmartPumps, Watson-Marlow® Series 114
Cold Finger Solenoid Digital Solenoid Valve
Gas Control (TruFlow)Standard: Four (4) MFCs with Two (2) Output ConnectorsOptional: Six (6) MFCs with Three (3) Output Connectors
Scales / Load Cells Analog Input via Scale Port
Auxiliary Connectors Seven (7) Analog Inputs and Four (4) Analog Control Loops
Digital Input Two (2) 24V DC
Digital Output Two (2) Dry-Relay Contacts
Thermal Control Heater Blanket, Chilled Water Source
External Pumps Two (2) Watson-Marlow® Pumps on a Finesse Pump Tower
pH Cables K8, VP, TruFluor
DO Cables D4, VP6, VP8, TruFluor
Heater IEC5-15 Receptacle
VesselsGlass, 1 L to 20 LSingle-Use (SUB), 2.4 L to 45 LRocker, 10 L to 50 L
Standard Colors* (pictured below)*Also available in clearcoated stainless as standard. Additional and custom colors are available at extra charge and longer lead times. The color examples shown are for reference only. Printed and on-screen colors may vary from actual product color.
Lime Blueberry Raspberry Tangerine Sterling Silver
SmartControllers | Bioreactor Controllers
G3LiteSPECIFICATIONS
Utility Tower Dimensions (H x W x D) 1600 x 680 x 540 mm (63 x 27 x 21 in)
Enclosure Rating NEMA12 / IP52
Operating Temperature 5ºC to 40°C (41ºF to 104°F)
Storage Temperature -25ºC to 70°C (-15ºF to 158°F)
Relative Humidity 5% to 95% Non-Condensing
Certifications Manufactured to conform to CE specifications EN-60101 and EN-61325
Weight / Shipping Weight 68 kg / 136.1 kg (150 lbs / 300 lbs)
Agitation Thermo Scientific HyPerforma™ SUBs: 1/4HP or 1/2HP AC 3-Phase Induction Motor
pH (Up to 2 Inputs) TruSens Transmitter (Electrochemical), TruFluor pH Transmitter (Single-Use)
DO (Up to 2 Inputs) TruSens Transmitter (Electrochemical), TruFluor DO Transmitter (Single-Use)
Temperature TruSens Transmitter (RTD) and/or TruFluor pH/DO Transmitters (Single-Use)
Pressure TruTorr Transmitter (Single-Use)
Liquid control Four (4) variable-speed peristaltic SmartPumps, Watson Marlow® Series 114, 313, or 520
Gas Control (TruFlow)Basic: Four (4) MFCs with Two (2) Output Connectors Recommended: Six (6) MFCs with Three (3) Output Connectors
Scales / Load Cells SmartScale Transmitter
Auxiliary Two (2) Analog Inputs (12-bit, 4 to 20 mA); Two (2) Auxiliary Control Loops (4 to 20 mA)
Digital Output Two (2) 24V Outputs; One (1) Dry Relay Alarm Contact
Thermal Control Heater Blanket or Analog Temperature Control Unit (TCU)
Vent Filter Heaters Two (2) Heaters for Pall KA3™ or Meissner UltraCap® 10-inch Filters
External PumpsUp to two (2) Additional External SmartPumps, Watson Marlow® Series 114, 313, 520, 620 Freestanding or on a Finesse SmartPump Tower
pH Cables K8, VP, TruFluor
DO Cables D4, VP6, VP8, TruFluor
Vent Filter Heater Connection IEC 60309 6H Receptacle 2P+E or External Heater Power Box for Larger Jacketed SUBs
SUBs (Single-Use Vessels) 50 L to 2000 L
HMI Standard Flatscreen Color Monitor, Washable Keyboard and Mouse
SmartControllers | Bioreactor Controllers
*Note that the controller is not designed to be free-standing. For this reason the controller is only shipped with the cart, for a combined weight of 116 kg (256 lbs)
SPECIFICATIONS
Utility Tower Dimensions (H x W x D) 914.4 x 609.6 x 228.6 mm (36 x 24 x 9 in)
Cart Dimensions (H x W x D) Stand Alone Mounting Cart with Wheels
178 x 71 x 81 cm (70 x 28 x 32 in)
Enclosure Rating NEMA 12/IP54 or optionally NEMA 4X/IP65
Operating Temperature 5°C to 40°C (41ºF to 104°F)
Storage Temperature -25°C to 85ºC (-13ºF to 185ºF)
Relative Humidity 5% to 95% Non-Condensing
Certifications Tested and Verified as Meeting CE Standards EN-60101 and EN 61325
Weight / Shipping weight 18.1 kg / 41 kg (40 lbs / 90 lbs)
Cart Weight* 75 kg (165 lbs)
Agitation Depends on Vessel Manufacturer, Control Through VAB (Vessel Adaptor Box)
pH (Up to 3 Inputs) TruSens Transmitter (Electrochemical), TruFluor pH Transmitter (Single-Use)
DO (Up to 3 Inputs) TruSens Transmitter (Electrochemical), TruFluor DO Transmitter (Single-Use)
Temperature TruSens Transmitter (RTD) and/or TruFluor pH/DO Transmitters (Single-Use)
Pressure TruTorr Transmitter (Single-Use)
Liquid control Four (4) variable-speed peristaltic SmartPumps, Watson Marlow® Series 114, 313, or 520
Gas Control (TruFlow)Standard: Six (6) MFCs with Three (3) Output ConnectorsOptional: Four (4) MFCs with Two (2) Output Conntectors
Scales / Load Cells Analog Input on Vessel Adapter Box
Auxiliary Eight (8) Analog Inputs and Four (4) Analog Control Loops
Digital Output Two (2) 24V Outputs; One (1) Dry Relay Alarm Contact
Thermal ControlHeater Blanket or Chilled Water Source (up to 250 L Vessel)Thermal Control Unit (TCU) for Jacketed Vessels
Vent Filter Heaters MKS Cable Compatible with Pall or Meissner Vent Filter Heaters
External Pumps Watson Marlow (Series 100, 300, 500 or 600) in Standalone SmartPump or SmartPump Tower
pH Cables K8, VP, TruFluor
DO Cables D4, VP6, VP8, TruFluor
Heater Connection Cable Specific to Heater Connected at VAB (Vessel Adapter Box)
SUBs (Single-Use Vessels) 50 L to 2000 L
Vessel Adapter Box (VAB)
Thermo Scientific HyPerforma™ SUB: 50, 100, 250, 500, 1000, 2000 LGE / Xcellerex XDR: 50, 200, 500, 1000, 2000 LATMI PadReactor: 25, 50, 600, 1350 LMillipore Mobius CellReady: 50, 200 LSartorius STR: 50, 200, 500, 1000 L ASI™ 50, 300 L
Third Party Sensors (Analog Output) CO2 – Mettler Toledo®; Cell Density – Endress+Hauser; Cell Viability – Aber™ / Fogale; Pressure / Flow
HMI 19 in Color Touch Screen Industrial LCD, NEMA 4X, 1280 x 1024, 24-Bit Color, Keyboard and Mouse
G3Pro Universal
SmartControllers | Bioreactor Controllers
G3FlexThe Finesse G3Flex is a custom bioprocess controller based on
SmartParts and designed to fill a specific application requirement.
For more information about the Finesse G3Flex, please
contact your local Finesse representative.
* Subject to change without notice. **Minimum pressure differential depends on flow rate 30 slpm requires 20 psi differential, 1 slpm or less requires 10 psi.
TruFlow Gas ManifoldGENERAL SPECIFICATIONS*
Operating Temp 5ºC to 40ºC (41ºF to 104ºF)
Storage Temp -25ºC to 70ºC (-15ºF to 158ºF)
Relative Humidity 5% to 95% (Non-Condensing)
Certification CE (EN-61326 and EN-61010)
Inlet Pressure 0.7 to 3.45 bar / 10 to 50 psig
Outlet Pressure 0 to 1.38 bar / 0 to 20** psig
Accuracy ±0.8% of Rate ±0.3% Full Scale (Burkert)
Repeatability ±0.1% Full Scale (Burkert)
PHYSICAL DESCRIPTION 4x2 GAS MANIFOLD 6x3 GAS MANIFOLD
Dimensions (H x W x D) 190.5 x 177 x 184.2 mm (7.5 x 7.0 x 7.25 in) 190.5 x 267 x 184.2 mm (7.5 x 10.5 x 7.25 in)
Rating NEMA 2 / IP11 NEMA 2 or NEMA 4X (Optional)
Weight / Shipping Weight 4.5 kg / 6.8 kg (10 lbs / 15 lbs) 7.3 kg / 9.1 kg (16.2 lbs / 20 lbs)
COMPONENTS
Mass Flow Controllers Up to Four (4) Per Vessel for G3Lab Up To Six (6) Per Vessel (Standard)
Solenoid Valves Two (2) Per Gas Three (3) Per Gas
Headers / Spargers Two (2) Total Per Manifold Three (3) Total Per Manifold
Every effort has been made to ensure the accuracy of the information in this document. However, Finesse
reserves the right to change its products without notice. The following are Finesse Solutions, Inc. registered
trademarks: TruView, TruBio, TruBio DV, TruBio µC, SmartOPC, TruService, TruTorr, TruFluor, TruLogic, TruConnect,
TruMigrations, TruCables, TruHousings, SmartGlass, SmartRocker, TruDO, TrupH, SmartFactory, SmartChip,
SmartSystems, SmartBag, SmartPuck, SmartReader, SmartBag Reader, SmartTray, SmartController, SmartSensor.
© 2013-2014, Finesse Solutions, Inc. All other trademarks are the property of their respective owners.
Finesse Solutions, Inc.
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