Current Directions in NIEHS Current Directions in NIEHS Extramural ProgramsExtramural Programs
J. Patrick Mastin, Ph.D.J. Patrick Mastin, Ph.D.Chief, Cellular, Organs, and Systems Pathobiology BranchChief, Cellular, Organs, and Systems Pathobiology Branch
Division of Extramural Research & TrainingDivision of Extramural Research & TrainingNIEHSNIEHS
NIH Grants Process
NIEHS Strategic Plan (more tomorrow morning, 7:30)
New Investigators Pathway to Independence
(K99/R00) ONES Award NIH New Investigators Policy
Training / Career Development Funding Opportunities
OverviewOverview
The NIH Grant ProcessThe NIH Grant ProcessThe NIH Grant ProcessThe NIH Grant Process
What happens in the Black Box ?
NIH Grant Process
Funding Mechanisms Important Personnel Overview of NIH Grant Process
Submission Referral Review Award Post-award
The NIH Grant ProcessThe NIH Grant ProcessThe NIH Grant ProcessThe NIH Grant Process
Grant MechanismsGrant Mechanisms“R”: Research Project
R01R03 (Small Research Grants)R21 (Exploratory/Developmental Grants)R43 (Small Business Innovation Research Grants)
“P”: Multi-component projects
P01 (Program Projects)P30 & P50 (Center Grants)
“T”: Institutional Training
T32T35: Short-term Training
“F”: Fellowships F30 (MD/PhD)F31 (Diversity pre-doctoral)F32 (National Service Research Award)
“K”: Career Development
K99/R00 (Pathways to Independence Award)
Although there are many mechanisms, not all mechanisms are available at all Institutes under all
circumstances.
http://grants.nih.gov/grants/funding/ac.pdf
Important PersonnelImportant Personnel
PROGRAMADMINISTRATOR
GRANTSMANAGEMENT
SPECIALIST
SCIENTIFICREVIEW
ADMINISTRATOR
Important PersonnelImportant Personnel
Responsible for the programmatic, scientific and/or technical aspects of a grant
Program Administrator (PA)
Develop research programs
Provide guidance and assistance to applicants
Attend study section meetings
Communicate results of review
Make funding recommendations
Post-award administration
GRANTSMANAGEMENT
SPECIALIST
SCIENTIFICREVIEW
ADMINISTRATOR
PROGRAMADMINISTRATOR
Manages activities of a scientific review group
Important PersonnelImportant Personnel
Scientific Review Administrator (SRA)
Performs an initial administrative review of applications
Assembles study section panel and assigns applications to individual reviewers
Serves as the overall point of contact with applicants
Prepares Summary Statements
PROGRAMADMINISTRATOR
GRANTSMANAGEMENT
SPECIALIST
SCIENTIFICREVIEW
ADMINISTRATOR
Responsible for the business management aspects of grants
Important PersonnelImportant Personnel
Grants Management Specialist (GMS)
Evaluate grant applications for administrative content and compliance with statutes, regulations and guidelines
Negotiates grants
Provides consultation and technical assistance
Administers and closes out grants
PROGRAMADMINISTRATOR
GRANTSMANAGEMENT
SPECIALIST
SCIENTIFICREVIEW
ADMINISTRATOR
Note: There are 3 “Council Rounds” per year.
These correspond to the times when the institutes’ Advisory Councils meet.
• “September Council” (“October”)
• “January Council” (“February”)
• “May Council”
Overview of NIH Grant ProcessOverview of NIH Grant Process
Overview of NIH Grant ProcessOverview of NIH Grant Process
Review
Award
Post-award
SubmissionReceipt and ReferralReview
Award
SubmissionTypes of applications
SubmissionTypes of applications
Unsolicited“Investigator-Initiated”
Program Announcements (PA)Request for Applications (RFA)
SolicitedUsed when NIH wants to solicit
applicationsin a particular area or on a particular topic
or using a particular grant mechanism
Funding Opportunity Announcement (FOA)
Majority of applications, e.g., most R01s
All applications, even the “unsolicited” ones, have FOA numbers
SubmissionTypes of applications
SubmissionTypes of applications
To find out aboutFunding Opportunity
Announcements(FOA)
NIH Guide for Grants and Contractshttp://grants.nih.gov/grants/guide/index.html
What to submit: Application Forms
All applications must besubmitted on
PHS 398SF424
PastNow Most electronically
•http://era.nih.gov/ElectronicReceipt/
Electronic SubmissionElectronic Submissionhttp://era.nih.gov/ElectronicReceipt/
Recommendation
Contract an appropriate Program Administrator in an appropriate institute before submitting (and preferably before you finishing the writing) your application.
Overview of NIH Grant ProcessOverview of NIH Grant Process
Receipt and Referral
Review
Award
Post-award
Submission
Receipt and Referral
Receipt and Referral
Center for Scientific ReviewDivision of Receipt and Referral
Receipt: Check for completeness, enter information into database, assign number, etc.
Referral (assignments)1. To a review group (“study section”)2. To a funding agency (e.g., NIEHS,
NCI, etc.)
Note: You can request a certain institute for funding or a study section for review. Requests won’t always be honored.
Overview of NIH Grant ProcessOverview of NIH Grant Process
Referral
Review
Award
Post-award
Submission
ReviewReview
Study sections at the Institutions For special circumstances
e.g., RFAs & PAs (FOAs)
Center for Scientific Review Study Sections(n = lots)
Most applications reviewed here
ReviewReview
1. “Streamlined”: Lower half; “Unscored”2. Scored: 100 (best) to 500 (worst)3. “Not Recommended for Further
Consideration” (“nerfed”)
Applications are mailed to Reviewers (on CD)
Reviewers read and evaluate applications, and prepare written comments
Review meeting: Reviewers discuss applications individually and give them a rating
National Advisory Health Sciences Council(“Secondary Review”)
Council accepts or rejects review of the study section
If recommendations are rejected, the Council may defer for a re-review. It can’t change the score.
ReviewReview
Overview of NIH Grant ProcessOverview of NIH Grant Process
Referral
Review
Award
Post-award
Submission
Funding ConsiderationsFunding Considerations
Recommendations for funding are based on
Summary Statement: Score and summary statement narratives
Programmatic Priorities
Budgetary Considerations
If the application is approved for funding: there are negotiations between NIH and applicant, if necessary, and an award is made.
If the application not approved for funding, applicant can revise and resubmit (up to 2 more times).
Overview of NIH Grant ProcessOverview of NIH Grant Process
Referral
Review
Award
Post-award
Submission
Post-AwardPost-Award
Yearly Progress Reports
Competitive Renewal (for some mechanisms)
Fame and Fortune
The Plan, The Vision
• Input from the public and discussions at a Strategic Planning Forum resulted in development of three major Challenges and seven major Goals that are put forward in the Strategic Plan.
• These Challenges and Goals are in fulfillment of the NIEHS vision:
The NIEHS vision is to prevent disease and improve human health by using environmental sciences to understand human biology and human disease.
Goals
1. Expand the role of clinical research in environmental health sciences.
2. Use environmental toxicants to understand basic mechanisms in human biology.
3. Build integrated environmental health research programs to address the cross-cutting problems in human biology and human disease.
4. Improve and expand community-linked research.
Goals
5. Develop sensitive markers of environmental exposure, early (preclinical) biological response, and genetic susceptibility.
6. Recruit and train the next generation of environmental health scientists.
7. Foster the development of partnerships between the NIEHS and other NIH institutes, national and international research agencies, academia, industry, and community organizations to improve human health.
Recent Requests for ApplicationsRecent Requests for ApplicationsGene-Environment Initiatives (GEI)
DISCOVER: Disease Investigation through Specialized Clinically-Oriented Ventures in Environmental Research
Comparative Biology Elucidation of Environmental Pathways and Susceptibility
Manufactured Nanomaterials: Physico-chemical Principles of Biocompatibility and Toxicity
Institutional Patient-Oriented Career Development Programs in the Environmental Health Sciences
http://www.niehs.nih.gov/dert/announce.htm
New Investigators are identified in post-council funding discussions by program administrators at NIEHS, and are given preferential consideration. NIEHS has established the Outstanding New Environmental Health Scientist (ONES) award, a first time R01 grant for scientists in the early, formative stage (less than 8 years from the doctoral degree) of their career.
New Investigators are identified in post-council funding discussions by program administrators at NIEHS, and are given preferential consideration. NIEHS has established the Outstanding New Environmental Health Scientist (ONES) award, a first time R01 grant for scientists in the early, formative stage (less than 8 years from the doctoral degree) of their career.
Outstanding New Environmental Scientist (ONES) Award
Outstanding New Environmental Scientist (ONES) Award
Outstanding New Outstanding New Environmental Scientists Environmental Scientists (ONES)(ONES)
Goals of the ONES Program: Identify outstanding scientists who are in
the early, formative stages of their careers and who intend to make a long term career commitment to research in the mission areas of the NIEHS
Assist them in launching an innovative research program focusing on problems of environmental exposures and human biology, human pathophysiology and human disease.
Provide R01 support Highly competitive review process Provide support for resource
development and career enhancement, separate from research funding Can be used for training, sabbaticals, etc. Can be used as for resource development:
equipment, staff, cohort development, etc.
Unique Features of ONES awards
Outstanding New Outstanding New Environmental Scientists Environmental Scientists (ONES)(ONES)
To be qualified, applicants Must be New Investigator: < 8 years
postdoctoral experience Must be Assistant, Research Assistant
Professor, or equivalent, and must show evidence of independent productivity and facilities
Must show a long-term commitment to Environmental Health Sciences research
Must show strong departmental and institutional support for their career development
ONES award would be first R01 Support
Outstanding New Outstanding New Environmental Scientists Environmental Scientists (ONES)(ONES)
2007 NIH Director's New Innovator 2007 NIH Director's New Innovator Award ProgramAward Program
New investigators who have not yet obtained an NIH R01 or similar grant
Must have received a doctoral degree or completed a medical internship and residency in 1997 or later
Up to $1.5 million in direct costs over five years Application period opens on April 25 and closes
on May 22, 2007 NIH expects to make at least 14 awards in
September 2007 http://grants.nih.gov/grants/new_investigators/
innovator_award/
Outstanding New Environmental Scientist Award (ONES) (Recurring RFA)
NIH Director's New Innovator Award Program (RM-07-009)
NIH Pathway to Independence (PI) Award (K99/R00) (PA-07-297)
Human Genes and the Environment Research Training Program (ES07-002) -- Application Receipt Date June 29, 2007
Short Term Educational Experiences for Research (STEER) in the Environmental Health Sciences for Undergraduates and High School Students (R25) (ES06-009)
Administrative Supplements to Support High School Student and College Undergraduate Research Experiences
Research Supplements to Promote Diversity in Health-Related Research (PA-05-015)
Current Training Funding OpportunitiesCurrent Training Funding Opportunities
http://www.niehs.nih.gov/dert/announce.htm
Current Directions in NIEHS Current Directions in NIEHS Extramural ProgramsExtramural Programs
J. Patrick Mastin, Ph.D.J. Patrick Mastin, Ph.D.Chief, Cellular, Organs, and Systems Pathobiology BranchChief, Cellular, Organs, and Systems Pathobiology Branch
Division of Extramural Research & TrainingDivision of Extramural Research & TrainingNIEHSNIEHS