Clinical Drug Investigation

Prevalence of desloratadine slow metabolizer phenotype and

food-dependent pharmacokinetics of desloratadine in

healthy Chinese volunteers

Ting Wang1, Kun Zhang1, Tingting Li2, Lin He3, Huiru Xie1, Xuehua

Jiang1 and Ling Wang1

Corresponding author:

Ling Wang. E-mail: rebeccawang312@gmail.com

1 Department of Clinical Pharmacy and Pharmacy Administration, Key

Laboratory of Drug Ministry of Education, West China School of

Pharmacy, Sichuan University, China,

2 Pharmacy Department of People's Hospital of Xishuangbanna Dai

Autonomous Prefecture, China,

3 Department of Pharmacy, Sichuan Provincial People’s Hospital,

China

Electronic Supplementary Material

Supplemental Figure Legends

Fig. S1. Chemical structures with fragmentation and product ion spectrum of [M + H]+ of desloratadine

(a), 3-OH-desloratadine (b) and diphenhydramine (c) (IS).

Fig. S2. MRM chromatogram of blank plasma (a); blank plasma spiked with desloratadine and

3-OH-desloratadine with their IS (10 ng/mL) at the LLOQ (0.05 ng/mL) (b); a plasma sample obtained

from a subject at 1.5 h post dosing (c).

Fig. S3. Individual pharmacokinetic parameters for desloratadine (a, b) and 3-OH-desloratadine (c, d)

following oral administration of 5 mg desloratadine tablet.

Fig. S1

Fig. S2

Fig. S3