Chem 509Signal Transduction
Winter 2012
Lecture 1
6 general classes of receptors
Ligand, agonist, antagonist
Autocrine, paracrine, endocrine: three mechanisms of signaling cells
Fight or Flight Response
http://monmouthfamilywellness.com/yahoo_site_admin/assets/images/fight-or-flight.107165735_std.jpg
Cholera
Vibrio cholerae
http://geo.arc.nasa.gov/sge/health/sensor/diseases/cholera.html
http://blackminis.wordpress.com/2008/12/12/winter-brings-infection/
AKAP: A kinaseanchoring protein
Protein Kinase A
Termination of beta adrenergic signaling pathway:
1. Epinepherine concentration is lowered.2. GAP activity of Gs alpha (GTP converted to GDP)3. cAMP phosphodiesterase4. Phosphorylation of beta-adrenergic receptor
-kinase is beta-adrenergic receptor kinase(BARK)-also known as G protein-coupled receptor kinase 2
5. Association of phosphorylated beta-adrenergic receptor with arrestin. This is followed by receptor endocytosis.
End of Lecture 1