Case 39
M55. 15yr H/O eczematous eruption neck, axillae and groins.
• A Hailey - Hailey disease with pseudoherpetic features
• B Herpesvirus infection
• C Hailey - Hailey disease with coexistent herpesvirus infection
• D Galli-Galli disease
HSV II
Primary acantholytic disorders and herpesvirus infection: clinical issues
• Herpesvirus infection coexisting at sites affected by a primary acantholyticdisorder (i.e. HHD): results in localized disease flare without widespread dissemination.
• Widespread primary or recurrent herpesvirus infection with systemic upset complicating a primary acantholytic disorder (Darier>Grover>>HHD): dermatological emergency (Kaposi’s varicelliform eruption)!
Case 39
• A Hailey - Hailey disease with pseudoherpetic features
• B Herpesvirus infection
• C Hailey - Hailey disease with coexistent herpesvirus infection
• D Galli-Galli disease
Primary acantholytic disorders and herpesvirus like changes: histopathological issues
Pseudoherpetic changes (in Grover’s disease)
Pseudoherpetic changes (in Grover’s disease)
Am J Dermatopathol. 2014; 36: 746-750.
HHD and herpesvirus infection: learning points
• Primary acantholytic disorders are classified on the basis of: location and extent of acantholysis, presence or absence of dyskeratosis, nature of the dermal inflammatory infiltrate and IF findings.
• Coexistance of a primary acantholytic disorder and herpesvirus infection may potentially herald a life threatening condition (KVE).
• Cytologically, acantholytic cells of a primary acantholytic disorder may be confused with herpesvirus infected cells (pseudoherpetic changes).