X-axis: 3MC Stage 2 (Default Interpretation) : Treatment f ...Y-axis: 3MC Stage 2 (Default Interpretation) : Treatment f ...

Colored by: 3MC Stage 2, Default Interpretation (Treatme...Gene List: good 3mc (9294)

1000 1e4

1000

1e4

Treatment f 3MC d01 (control)

X-axis: 3MC Stage 2 (Default Interpretation) : Treatment a ...Y-axis: 3MC Stage 2 (Default Interpretation) : Treatment a ...

Colored by: 3MC Stage 2, Default Interpretation (Treatme...Gene List: good 3mc (9294)

100 1000 1e4

100

1000

1e4

Treatment a Olive d01 (control)

a Olive d01 c Olive d04 e Olive d16 f 3MC d01 g 3MC d02 h 3MC d04 i 3MC d08 j 3MC d16Treatment

0.1

1

10

a Olive d01 c Olive d04 e Olive d16 f 3MC d01 g 3MC d02 h 3MC d04 i 3MC d08 j 3MC d16Treatment

0.1

1

10

Carrier Controls 3-MC 25mg/kg

Day after IP injection

1 2 4 8 16 1 2 4 8 16

10 fold up

1:1

10 folddown

Treated fish show many changes in gene expressionWhich genes and which pathways are altered??

Clones 2-fold induced at day1 3-MCBenjamini & Hochberg MTC, P<0.05

Scatter plot 3MC day 1

Scatter plot control day1