CardioInspectCardioInspect
Diagnostic and Monitoring SystemsDiagnostic and Monitoring Systemsfor Congestive Heart Failure (CHF) for Congestive Heart Failure (CHF)
PatientsPatients
TAU Future Technology Development L.PTAU Future Technology Development L.P . .
The TechnologyThe Technology EIT – Electrical Impedance TomographyEIT – Electrical Impedance Tomography
• Electrical Impedance tissue property is imaged Electrical Impedance tissue property is imaged non invasivelynon invasively
Chest belt with Chest belt with disposable electrodesdisposable electrodes
Current Source Unit
Voltage Measurement
Unit
Control and Acquisition Unit
Reconstruction Algorithm
CardioInspect Standalone CardioInspect Standalone PrototypePrototype
Clinical TrialsClinical Trials
Clinical ResultsClinical ResultsMonitoring Lung Edema Monitoring Lung Edema
LevelLevelEdema Improvement
+35%
+16%
Significant increase in resistivity values reflect improvement of lung
fluid level
Lung
Res
istiv
ity [O
hm*c
m]
Measurement #
The Telemedicine Home The Telemedicine Home SystemSystem
Recording Phase Transmitting Phase
Clinical data as received at the medical center
The Telemedicine Home The Telemedicine Home SystemSystem
Healthy Subject
CHF Patient
Confidential
Diagnostic and Monitoring EIT Systemfor Osteoporosis
Confidential
Vision Statement
8
Revolutionize the diagnostics and monitoring of Osteoporosis in the clinic and
at home by introducing an EIT based technology that can be integrated within a
hand wristband
Confidential
Proposed Solution
9
Deliver a novel Electrical Impedance Tomography (EIT) based technology as an alternative to the DEXA solution:Inexpensive relative to other existing techniquesDoes not utilize ionizing radiation and well suited for long-term tracking that is often required in Osteoporosis managementUtilized using simple and compact hardware; Can be applied in small clinics and at home
Current Source Unit
Voltage Measurement
Unit
Control and Acquisition Unit
Reconstruction Algorithm
Utilizing EIT:Provides information about the spatial electrical conductivity distribution within the human bodyBased on applying small magnitude alternating electric currents to the body and measuring developing electric potentials on the body surfaceThe large variation in bone tissue electric and dielectric properties during Osteoporosis, makes EIT a promising technique for monitoring and diagnosing
Confidential
10
Technical Background (1 of 4)
Forward formulation - Calculation of the spatial electrical potential due to known current sources and conductivity distribution
source
source
J
:conductor volumea in equations fields EM sMaxwell'by Solution
Jf
),(
Mathematical Formulation
Inverse formulation - Calculation of the spatial conductivity distribution due to known current sources and surface voltages
algorithmRaphson -Newton iterativeby Solution
),( surfacesourceJf
Confidential
11
Technical Background (2 of 4)
The Newton-Raphson algorithm
Initial Guess - 0
Forward Solver
Calculated surface potentials
Measured surface potentials Cost
function
<yes
Endno
k+1=k+k+1
Confidential
12
Technical Background (3 of 4)
Displayed above are human body computerized model cross section results of the wrist and forearm as received from our preliminary numerical study, using a set of 5 electrodes on the surface of the wrist and measuring the surface potentials. Very strong correlation was found between the Impedance and BMD
Numerical computational simulation
Confidential
13
Technical Background (4 of 4)
Preliminary real measurements using the developed prototype
Results of 7 real tests from 5 healthy subjects and 2 patients with documented osteoporosis
The prototype during measurement
Good correlation was obtained between the measured impedance and age