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Carbapenem resistance
PRESENTER : Dr. AISHIYA
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Carbapenems are a classof beta-lactam antibioticswith very broad activity
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Lactam Antibiotics
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Most widel !rescribed
dr"#s
Penicillin Monobactams
$arbe!enems
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Penicillins
betalactamases
Ist generation cepalosporins
2ndgeneration cephalosporins
3rdgeneration cephalosporins
Extended spectrmbetalactamases
!- "actam Inhibitors # C$%&EPE'E()
%esistance
*
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BACTERIAL RESISTANCE
Even in presence of antimicrobials+ ifpathogenic microorganisms is mltiplying
treatment otcome is compromised,
his phenomenon is referred to as antimicrobial
resistance .$(%/,
0
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SURVIVAL OF THE FITTEST
%esistant bacteria srvive+ ssceptible ones die
(tant emergesslowly
)ensitive cellsilled by antibiotic
(tants progenyoverrn
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&ENETI$ 'I($HEMI$AL
E))L*+P*MPS
M(DI)I$ATI(N() TAR&ETSITES
$HR(M(S(MA
L
E+TRA
$HR(M(S(MAL
INA$TI,ATIN&EN-YMES
E#: /Lactamases
BACTERIAL RESISTANCE
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BACTERIAL RESISTANCE
0.&ENETI$
Chromosomal 5
Extrachromosomal5
Plasmids
C6'789$I6'
%$'):8CI6'
%$');6%($I6'
idime 2-(CP cefta>idim
e2-(CP
Enhancement of inhibition >one towards 2-(CP disc
3
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3
I(IPE'E(
Imipenem N&6%6'IC $CI:
&6%6'IC$CI: :I)C
E)
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(6"EC8"$% EC'IO8E)
)eGencing 3<
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NE9ER Dr"#sTi#eccline)os7omcinPolmin$olistin
4=
P%EBE'I6'
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P%EBE'I6'
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Hand was%in# still t%e best
o!tion to !re6ent s!read o7 $REand hygiene is aprimary part ofpreventing mltidrg-
resistant organism.(:%6/ transmission,
;acilities sholdensre thathealthcare personnel
are familiar with 42
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9e ma not be able to sto! t%eemer#ence o7 S"!er b"#s
b"t we $AN
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