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Bisa Stem Cell Therapy HIV dan AIDS
Cure?
The Simple Answer is: "Yes, It is Very Possible"
Jawaban yang sederhana adalah: "Ya, itulah Sangat
Mungkin"Feb 12, 2010 Robert MaiettaFeb 12, 2010 Maietta Robert
HIV virus seen as small spheres on cell surface. Virus HIV dilihat sebagai bola kecil di permukaan sel.
- C. - C.Goldsmith at the CDCTukang emas di CDC
Scientists at the Bedford Stem Cell Research Foundation propose to develop stem cells into immune
cells that are resistant to HIV infection thereby affecting a cure. Para ilmuwan di Bedford Stem Cell
Research Foundation mengusulkan untuk mengembangkan sel induk menjadi sel-sel kekebalan yang
tahan terhadap infeksi HIV sehingga mempengaruhi obat.
Scientists in Berlin "Cure" Patient of HIV Disease Para ilmuwan di
Berlin Pasien "Cure" Penyakit HIV
The basic science for this proposal to cure HIV and AIDS with stem cell therapy is supported by a
report published in The New England Journal of Medicine in February of 2009. Ilmu dasar untuk
proposal ini untuk menyembuhkan HIV dan AIDS dengan terapi sel batang didukung oleh laporan
yang diterbitkan dalam The New England Journal of Medicine pada bulan Februari tahun 2009. In this
report, Berlin doctors describe a male patient who has both HIV infection and leukemia. Dalam laporan
ini, dokter Berlin menggambarkan seorang pasien laki-laki yang baik infeksi HIV dan leukemia. In
order to treat this patient's leukemia, doctors transplanted stem cells from a donor who was naturally
resistant to the HIV virus. Dalam rangka untuk mengobati leukemia ini pasien, dokterditransplantasikan sel induk dari donor yang secara alami resisten terhadap virus HIV. Such naturally
resistant people to the HIV virus comprise approximately 1% of the general population and are deemed
such as they have a genetic mutation of the CCR5 gene which is required for susceptibility to HIV
infection. orang tersebut secara alami tahan terhadap virus HIV terdiri dari sekitar 1% dari populasi
umum dan dianggap seperti mereka memiliki mutasi genetik dari gen CCR5 yang diperlukan untuk
kerentanan terhadap infeksi HIV. After the stem cell transplant for the patient's leukemia was
performed with the HIV resistant cells, the patient was able to discontinue taking all anti-HIV
medications and remained without detectable HIV virus in his blood for the 20 consecutive months he
was monitored. Setelah transplantasi sel induk untuk leukemia pasien dilakukan dengan sel HIV
resisten, pasien bisa menghentikan mengambil semua obat anti-HIV dan tetap tanpa virus HIV
terdeteksi dalam darah-Nya selama 20 bulan berturut-turut ia dipantau. In effect, this patient was
cured of his HIV disease. Akibatnya, pasien ini adalah "sembuh" dari penyakit HIV-nya.
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Patient-Specific Stem Cells Proposed to "Cure" HIV Disease Sel induk
Pasien Khusus Usulan untuk "Cure" Penyakit HIV
One of the difficulties that the patient mentioned above faced is that the bone marrow stem cells he
received were from a closely matched donor. Salah satu kesulitan yang disebutkan di atas pasien yang
dihadapi adalah bahwa sel-sel induk sumsum tulang yang ia terima berasal dari donor yang erat cocok.The patient still had to undergo significant immunosuppressive therapy in order that he did not reject
the donor cells and suffer graft vs. host disease. The scientists at the Bedford Stem Cell Research
Foundation propose to take the process one step further and avoid this problem by obtaining the stem
cells directly from the HIV infected patient patient specific stem cells. Pasien masih harus menjalani
terapi imunosupresif signifikan agar ia tidak menolak sel donor dan menderita Para ilmuwan di
Bedford Stem Cell Research Foundation mengusulkan untuk mengambil proses satu langkah lebih
lanjut dan menghindari masalah ini "penyakit graft vs host." dengan mendapatkan sel induk langsung
dari pasien terinfeksi HIV - sel induk spesifik pasien. In HIV positive females, these stem cells would
be derived from unfertilized eggs stem cells termed parthenotes. In HIV positive males, these stem
cells would be retrieved from the testes. Pada perempuan HIV positif, sel-sel induk akan berasal dari
telur yang tidak dibuahi - sel induk disebut "parthenotes." Pada laki-laki HIV positif, sel-sel batang
akan diambil dari testis. Once the stem cells are obtained, they would be developed in the laboratory
into immune system cells which are resistant to HIV infection by eliminating the CCR5 gene. Setelah
sel induk yang diperoleh, mereka akan dikembangkan di laboratorium menjadi sel-sel sistem kekebalan
tubuh yang tahan terhadap infeksi HIV dengan menghilangkan gen CCR5. Finally, these patient
specific HIV resistant immune cells would be injected back into the HIV infected patient where they
will populate, flourish, and overtake the existing HIV infected cells, thereby rendering the individual's
immune system resistant to the HIV virus. Akhirnya, ini khusus pasien HIV sel kekebalan tahan akan
disuntikkan kembali ke pasien yang terinfeksi HIV di mana mereka akan mengisi, berkembang, dan
menyalip sel yang terinfeksi HIV yang ada, sehingga rendering sistem kekebalan individu resisten
terhadap virus HIV. Such HIV infected individuals will no longer require anti-retroviral medication
which will relieve them of all the associated toxic side effects as well as the significant expense of the
therapy. Seperti orang yang terinfeksi HIV tidak akan lagi memerlukan obat anti-retroviral yang akan
membebaskan mereka dari semua efek samping toksik terkait serta beban yang signifikan dari terapi.
In addition to curing the patient's HIV disease, because the process uses patient specific stem cells,
there is no need for immunosuppressive therapy and no risk of graft vs. host disease. Selain
"menyembuhkan" pasien penyakit HIV, karena proses tersebut menggunakan sel induk spesifik pasien,
tidak ada kebutuhan untuk terapi imunosupresif dan tidak ada risiko "penyakit graft vs host."
Private Funding Required for HIV and AIDS Stem Cell Therapy
Development Pendanaan Swasta Diperlukan untuk HIV dan AIDS
Pengembangan Stem Cell Therapy
So, can stem cell therapy cure HIV and AIDS? Jadi, bisa terapi stem cell menyembuhkan HIV dan
AIDS? Yes, it is very possible as outlined in the process described above. Ya, itu sangat mungkin
seperti yang dijelaskan dalam proses yang dijelaskan di atas. Much research is needed to develop this
process and government funding is not available, so private funding will ultimately be required to
achieve these goals. Banyak penelitian diperlukan untuk mengembangkan proses ini dan dana dari
pemerintah tidak tersedia, pendanaan sehingga swasta pada akhirnya akan diperlukan untuk mencapai
tujuan tersebut.
References :Referensi:
Read on Baca terus Genetic Protections against HIV Genetik Perlindungan terhadap HIV
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The 2008 Nobel Prize in Medicine 2008 Penghargaan Nobel dalam Kedokteran
The Future of AIDS Masa Depan AIDS
Bedford Stem Cell Research Foundation: http://www.bedfordresearch.org/article/stem-cell-hiv-cure-
25214 Bedford Stem Cell Research Foundation: http://www.bedfordresearch.org/article/stem-cell-hiv-
cure-25214
New England Journal of Medicine; 360(7):692; February 12, 2009:http://content.nejm.org/cgi/reprint/360/7/692.pdf New England Journal of Medicine, 360 (7): 692, 12
Februari 2009: http://content.nejm.org/cgi/reprint/360/7/692.pdf
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