8/15/2019 Antivirus Dan Interferon
1/37
ANTIVIRUS DANINTERFERON
ARY SETIAWAN UMALEKHOA
143145201005
KELAS (A)
8/15/2019 Antivirus Dan Interferon
2/37
ANTIVIRUS
8/15/2019 Antivirus Dan Interferon
3/37
PENGGOLONGAN ANTIVIRUS
8/15/2019 Antivirus Dan Interferon
4/37
ANTI NONRETROVIRUS
Ant ! "#$ #nt#%&'" '$
• A$ % *! "• G+n$ % *! "• F+,$ % *! "• F*$%+"n't• T" - #" . n
Ant ! "#$ #nt#%n- #'n/+
• A,+nt+. n .+nR ,+nt+. n
• In& t*"N'#"*, n .+$'(O$' t+, ! "
+n+, ! ")• R +! " n
Ant ! "#$ #nt#%H V HV
• L+, !#. n• A.'-*! "• Ent'%+! "• Int'"-'"*n
8/15/2019 Antivirus Dan Interferon
5/37
ANTI NONRETROVIRUS6 A7V U H'" '$ 6 A$ %
• MK 8 D ,'t+ * $,' ,'n9+. +$ % *!" t" -*$-+t :+n; ,'n;&+, +t DNA* ,'"+$' ! "#$
• In. %+$ 8 n-'%$ HSV$'&+" 200,; t+ 't $'.+n;%+n #nt#% &'" '$
/*$t'" + +& 4?400,; $'&+" 7 'n;;#n++n t* =+ #nt#% %'"+t t $ &'" 't =+.+ +& .+ +, 'nt#% %" , * &t&+ , = 3@ .+n% " , 5@ #nt#% &'" '$ + + $7Unt#% &'" '$ 'n$'-+ t $ HSV '"+t + n n:+ .+n n-'%$ V V . ;#n+%+n+$ % *! " nt"+!'n+ 30,; %; '"&+" 7
• E-'% $+, n; 8 E-'% $+, n; t'";+nt#n; +.+ =+"+ ', '" +n7 M $+ n:+" t+$ *=+ .+ +t t'"9+. .+" ', '" +n t* =+ B $+% t %' + +B . +"'B ,#+
B.+n ,#nt+& ,'"# +%+n &+$ ', '" +n *"+ ;+n;;#+n -#n;$ ; n9+ .+ +t
t , # +.+ .*$ $ t n;; +t+# +$ 'n .'& ."+$ :+n; ,'n'" ,+ * +t $'=+"+nt"+!'n+7
8/15/2019 Antivirus Dan Interferon
6/37
ANTI NONRETROVIRUS6 A7V U H'" '$ 6A$ % *! "
8/15/2019 Antivirus Dan Interferon
7/37
ANTI NONRETROVIRUS6 A7V U H'" '$ 6G+n$ % *! "
• MK 8 D ,'t+ * $,' ,'n9+. ;+n$ % *! " t" -*$-+t :+n; ,'n;&+, +t DNA * ,'"+$' ! "#$• In. %+$ 8 In-'%$ MV t'"#t+,+ MV "'t n t $ +.+ +$ 'n ,,#n*=*, "*, $'. ( , $+ n:+ 8
AIDS ) + % #nt#% t'"+ +t+# 'n=';+&+n• S'. ++n .+n D*$ $ 8 Unt#% n.#%$ . '" %+n IV 10 ,; %; '" &+" ( 2 > 5 ,; %; $'t + 12
9+,) $' +,+ 14 $'&+" 4 %+ $# C 250 ,; )7 In +nt$ nt"+*=# +" ( nt"+! t"'+ ) 4 5 ,; ;n$ % *!$' +;+ t'"+ *=+ MV "'t n t $7
• E-'% $+, n; 8 , ' *$# "'$ .+ +t t'"9+. +.+ t'"+ .'n;+n ;+n$ % *! "7 N'*t"* 'n +t'"9+. +.+ 15
8/15/2019 Antivirus Dan Interferon
8/37
ANTI NONRETROVIRUS6 A7V U H'" '$ 6F+,$ % *! "
• MK 8 F+,$ % *! " ,'"# +%+n prodrug 'n$ % *= "7 F+,$ % *! " . #,' + # "*$'$ & ."* $ $ +.+ .#+ ;#;#$ +$'t n:+ .+n *%$ .+$ +.+
*$ $ < %',#. +n '%'"9+ $' '"t +.+ 'n$ % *! "7• In. %+$ 8 HSV
8/15/2019 Antivirus Dan Interferon
9/37
ANTI NONRETROVIRUS6 A7V U H'" '$ 6F*$%+"n't
• MK 8 ," %n +n+ *; *";+n % .+" "*-*$-+t *";+n %7 O +t n ,', #n:+%*, '%$ .'n;+n DNA * ,'"+$' ! "#$ +.+ t', +t %+t+n "*-*$-+t,'n=';+& '=+&n:+ "*-*$-+t .+" n#% '*$ .+ t" -*$-+t .+n +%+n,'n;&+, +t "*$'$ ',+n9+n;+n primer-template.
• In. %+$ 8 R't n t $ NV +.+ +$ 'n AIDS In-'%$ &' "'$ ,#%*t+n :+n
"'$ $t'n t'"&+.+ +$ % *! " (.'- $ 'n$ t , . n % n+$' ! "#$) $'"t+ n-'%$HSV .+n V V +.+ +$ 'n immunocompromised 7• D*$ $ 8 IV6 %+.+" 24 ,; , .+ +, *t* '" $ 250 .+n 500 ,• ES 8 N'-"*t*%$ $ t+$ .+n & *%+ $', + $ ,t*,+t %7
8/15/2019 Antivirus Dan Interferon
10/37
ANTI NONRETROVIRUS6 A7V U In- #'n/+ 6A,+nt+. n R ,+nt+. n
• MK 8 H+, +t+n %'n+ *n "*t' n M2 .+n ,*.# +$ H nt"+$' 7 In.#%$ 'n/ , $' # '":+n; ,'n;;+n;;# $ nt'$ $ "*t' n ! "#$
• In. %+$ 8 P'n=';+&+n .+n t'"+ + + n-'%$ ! "#$ n- #'n/+ A ( A,+nt+. n 9#;+. n. %+$ #nt#% t'"+ 'n:+% t P+"% n$*n )7
• D*$ $ 8 A,+nt+. n .+n " ,+nt+. n t'"$'. + .+ +, 'nt#% t+ 't .+n $ "# #nt#%'n;;#n++n *"+ 7 A,+nt+. n . '" %+n .+ +, .*$ $ 200 ,; '" &+" ( 2 ? 100 ,;
%+ $# )7 R ,+nt+. n . '" %+n .+ +, .*$ $ 300 ,; '" &+" ( 2 ? $'&+" 150 ,; t+ 't )7D*$ $ +,+nt+. n &+"#$ . t#"#n%+n +.+ +$ 'n .'n;+n n$#- $ 'n$ "'n+ n+,#n" ,+nt+. n &+n:+ '" # . t#"#n%+n +.+ +$ 'n .'n;+n % "'n$ %"'+t n n 10 , ,'n t7
• E-'% $+, n; 8 E-'% $+, n; SSP $' '"t %';' $+&+n %'$# t+n '"%*n$'nt"+$n$*,n + & +n; n+-$# ,+%+n7 R ,+nt+. n ,'n:' + %+n "'+%$ SSP ' & $'. % t %+"'n+
t .+% +n:+% ,' nt+$ $+ +" *t+% .+"+&7 E-'% n'#"*t*%$ % +,+nt+. n ,'n n;%+t 9 %+. '" %+n '"$+,++n .'n;+n +nt & $t+, n .+n * +t +nt %* n'"; % $ %*t"* %t'"#t+,+ +.+ #$ + +,9#t7
8/15/2019 Antivirus Dan Interferon
11/37
ANTI NONRETROVIRUS6 A7V U In- #'n/+ 6In& t*" N'#"+, n .+$' ( O$' t+, ! " +n+, ! " )
• MK 8 H+, +t+n t'"&+.+ n'#"+, n .+$' ,'n=';+& t'"9+. n:+ n-'%$ 7 N'#"+, n .+$'9#;+ #nt#% 'n; ' +$+n ! "#$ :+n; * t ,+ .+" $' :+n; t'" n-'%$ :+n; ,'n n;%+t%+n
'n:' +"+n ! "#$ .+n nt'n$ t+$ n-'%$ 7• In. %+$ 8 T'"+ .+n 'n=';+&+n n-'%$ ! "#$ n- #'n/+ A .+n 7• D*$ $ 8 +n+, ! " . '" %+n '" n&+ +$ .'n;+n .*$ $ 20 ,; '" &+" ( 2 ? 5 ,; $'t +
12 9+, )$' +,+ 5 &+" 7 O$' t+, ! " . '" %+n '" *"+ .'n;+n .*$ $ 150 ,; '" &+" ( 2
? 5 ,; %+ $# $'t + 12 9+, ) $' +,+ 15 &+" 7 T'"+ .'n;+n /+n+, ! " *$' t+, ! ".+ +t . '" %+n $'+ + ,#n;% n .+ +, +%t# 4 9+, $'t' +& *n$'t ;'9+ +7• E-'% $+, n; 8 T'"+ /+n+, ! " 8 ;'9+ + $+ #"+n n+-+$ .+n ;'9+ + $+ #"+n ='"n+7
.+ +t ,'n , # %+n +t#% "*n%*$ +$,' .+n 'n#"#n+n -#n;$ +"# "'!'"$ ' +.+' '"+ + +$ 'n7 T'"+ *$' t+, ! " 8 ,#+ ,#nt+& n:'" + .*,'n $+% t %' + +7
8/15/2019 Antivirus Dan Interferon
12/37
ANTI NONRETROVIRUS6 A7V U In- #'n/+ 6R +! " n
• MK 8 R +! " n ,'"# +%+n +n+ *; ;#+n*$ n :+n; = n= n #" nn:+ t .+% 'n;%+ 7• In. %+$ 8 T'"+ n-'%$ RSV +.+ +: .'n;+n "'$ %* t n;; 7 R +! " n . ;#n+%
.+ +, %*, n+$ .'n;+n nt'"-'"*n< ';: +t'. nt'"-'"*n J #nt#% t'"+n-'%$ &' +t t $ 7
• D*$ $ 8 P'" *"+ .+ +, .*$ $ 00
8/15/2019 Antivirus Dan Interferon
13/37
8/15/2019 Antivirus Dan Interferon
14/37
ANTI NONRETROVIRUS6 A7V U H V DAN HA.'-*! "
• MK 8 A.'-*! " ,'"# +%+n 'n;&+, +t "' %+$ H V $+n;+t %#+t :+n; '%'"9+t .+% &+n:+ $' +;+ DNA =&+ n t'", n+t*" n+,#n 9#;+ ,'n n;%+t%+n +%t ! t+$$' NK .+n ,'n; n.#%$ "*.#%$ nt'"-'"*n 'n.*;'n7
• In. %+$ 8 A.'-*! " t'" #%t '-'%t - .+ +, t'"+ n-'%$ H V :+n; "'$ $t'nt'"&+.+ +, !#. n7
• D*$ $ 8 P'" *"+ .*$ $ t n;;+ 10 ,; '" &+" 7• E-'% $+, n; 8 A.'-*! " 10,; &+" .+ +t . t* '"+n$ .'n;+n + %7 S't' +&
t'"+ $' +,+ 4 , n;;# t'"9+. 'n n;%+t+n %"'+t n n $'"#, 0 5 ,; .L .+t+$ +$' n' +.+ 13@ +$ 'n :+n; #,#,n:+ ,', % -+=t*" "'$ %* . $-#n;$"'n+ $'9+% + + t'"+ 7
8/15/2019 Antivirus Dan Interferon
15/37
ANTI NONRETROVIRUS6 A7V U H V DAN HEnt'%+! "
• MK 8 Ent'%+! " ,'n;+ +, -*$-*" +$ ,'n9+. 'nt#% t" -*$-+t :+n;+%t - :+n; '" '"+n $' +;+ %*, 't t*"$# $t"+t n+t#"+(.'*%$ ;#+n*$ n t" -*$-+t) $'"t+ ,'n;&+, +t H V * :,'"+$'7
• In. %+$ 8 In-'%$ H V7• D*$ $ 8 P'" *"+ 0 5 ,; &+" .+ +, %'+.++n '"#t %*$*n; +.+ +$ 'n
:+n; ;+;+ t'"+ .'n;+n +, !#. n ', '" +n 'nt'%+! " . t n;%+t%+n& n;;+ 1 ,; &+" 7
• E-'% $+, n; 8 S+% t %' + + n-'%$ $+ #"+n n+-+$ +t+$ +t#%n+$*-+" n; t $ -+t ;#' #$ n; n:'" + .*,'n +t+$ .+n ,#+ 7
8/15/2019 Antivirus Dan Interferon
16/37
INTERVER
8/15/2019 Antivirus Dan Interferon
17/37
ANTI NONRETROVIRUS6 A7V U H V DAN HIn't'"-'"*n
It'"-'"*n ,'"# +%+n $ t*% n :+n; '-'% +nt ! "#$,#n*,*.# +t*" .+n +nt "* -'"+t - :+n; . "*.#%$ * '&
t## #& $'+ +;+ "'$ *n .+" '" +;+ $t ,# #$7 A.+ t ;+t ' #t+,+ nt'"-'"*n8 + -+ 't+ .+n ;+,+7 S'. ++n
n+t#"+ .+n "'%*, n+n :+n; + n; +n:+% . ;#n+%+n.+ +, % n $ +. +& nt'"-'"*n + -+7
8/15/2019 Antivirus Dan Interferon
18/37
ANTI NONRETROVIRUS6 A7V U H V DAN HIn't'"-'"*n
8/15/2019 Antivirus Dan Interferon
19/37
ANTI NONRETROVIRUS6 A7V U H V DAN HIn't'"-'"*n
• MK 8 S't' +& '" %+t+n .'n;+n "$' t*" $' # +" :+n; $ '$ - % nt'"-'"*n,'n;+%t !+$ 9+ #" t"+n$.#%$ $ n:+ AK
8/15/2019 Antivirus Dan Interferon
20/37
ANTI RETROVIRUS
NRTI
• .*!#. n• D .n*$ n
NtRTI
• T'n*!*! "
NNRTI
• N'! "+ n• E-+! "'n/
PI
• S+%# n+! "• R t*n+! "
Viralinhi
• En-#• $
8/15/2019 Antivirus Dan Interferon
21/37
ANTI RETROVIRUS6 NRTI
R'!'"$' t"+n$%" $t+$' (RT ) ,'n;# +& RNA ! "#$ ,'n9+. DNA "*! "+$' ' #, '";+ #n; .'n;+n %"*,*$*, &*$ '$7
K+"'n+ +nt ! "#$ ;* *n;+n n '%'"9+ +.+ t+&+ + + "' %+$ HIV * +t* +t ;* *n;+n n ,'n;&+, +t t'"9+. n:+ n-'%$ +%#t $' :+n; "'nt+n t+&+n:+ $'. % t '"'-'% +.+ $' :+n; t' +& t'" n-'%$ HIV7
Unt#% .+ +t '%'"9+ $',#+ * +t ;* *n;+n NRTI &+"#$ ,'n;+ +, -*$-*" +$* '& 'n/ , $' &*$ '$ . $ t* +$,+7 Y+n; t'",+$#% %*, %+$ * '& * +t * +t
n +.+ +& +$ .*$ +%t+t .+n &' +t*,';+ '"+t .'n;+n $t'+t*$ $7
8/15/2019 Antivirus Dan Interferon
22/37
ANTI RETROVIRUS6 NRTI 6 .*!#. n
• MK 8 t+";'t / .*!#. n +.+ +& 'n/ , "'!'"$' t"+n$=" t+$' (RT) HIV7 .*!#. n'%'"9+ .'n;+n =+"+ ,'n;&+, +t 'n/ , "'!'"$' t"+n$=" t+$' ! "#$ $'t' +&
;#;#$ +$ .*t , . n (A T) +.+ / .*!#. n ,'n;+ +, -*$-*" +$ 7 G#;#$ A T 5 <,*n* -*$-+t +%+n '";+ #n; +.+ #9#n; 3 "+nt+ DNA ! "#$ .+n ,'n;&+, +t"'+%$ "'!'"$' t"+n$=" t+$'7
• In. %+$ 8 n-'%$ HIV .+ +, %*, n+$ .'n;+n +nt HIV + nn:+($' '"t
+, !#. n .+n + +%+- ")• D*$ $ 8 .*!#. n t'"$'. + .+ +, 'nt#% %+ $# 100 ,; t+ 't 300 ,; .+n
$ "# 5 ,; 5, . $ '"*"+ 00 ,; &+"• E-'% $+, n; 8 +n', + n'*t"* 'n + $+% t %' + + ,#+ 7
8/15/2019 Antivirus Dan Interferon
23/37
• MK 8 O +t n '%'"9+ +.+ HIV RT .'n;+n =+"+ ,'n;&'nt %+n', 'nt#%+n "+nt+ DNA ! "#$7
• In. %+$ 8 In-'%$ HIV t'"#t+,+ n-'%$ HIV t n;%+t +n9#t .+ +,%*, n+$ +nt HIV + nn:+7
• D*$ $ 8 t+ 't %+ $# $+ #t 'nt'" = '"*"+ 400 ,; &+" .+ +,.*$ $ t#nn;+ +t+# t'" +; 7
• E-'% $+, n; 8 . +"' +n="'+t t $ n'#" +t '" -'"7
ANTI RETROVIRUS6 NRTI 6 D .+n*$ n
8/15/2019 Antivirus Dan Interferon
24/37
ANTI RETROVIRUS6 NtRTI 6 T'n*!*! "
• MK 8 '%'"9+ +.+ HIV RT ( .+n H V RT ) .'n;+n =+"+ ,'n;&'nt %+n', 'nt#%+n "+nt+ DNA ! "#$7
• R'$ $t'n$ 8 D $' + %+n * '& ,#t+$ +.+ RT %*.*n 57• S '%t"#, +%t ! t+$ 8 HIV ( t ' 1 .+n 2 ) $'"t+ '" +;+ "'t"*! "#$
+ nn:+ .+n H V7• In. %+$ 8 In-'%$ HIV .+ +, %*, n+$ .'n;+n '!+- "'n$ t .+% * '&
. %*, n+$ .'n;+n +, -#. n .+n + +%+- "7• D*$ $ 8 P'" *"+ $'&+" 300 ,; t+ 't7• E-'% $+, n; 8 M#+ ,#nt+& F +t# 'n$ .+n . +"'7
8/15/2019 Antivirus Dan Interferon
25/37
ANTI RETROVIRUS6 NNRTI
M'"# +%+n %' +$ * +t :+n; ,'n;&+, +t+%t ! t+$ 'n/ , "'!'"$ t"+n$=" t+$' .'n;+n=+"+ '" %+t+n . t', +t :+n; .'%+t .'n;+n
t', +t +%t - 'n/ , .+n ,'n; n.#%$'"# +&+n %*n-*",+$ +.+ $ t#$ +% - n 7
S',#+$'n:+ + NNRTI . ,'t+ * $,' * '&$ t*%"*, P450 $'& n;;+ ='n."#n; #nt#%
'" nt'"+%$ .'n;+n * +t + n7
8/15/2019 Antivirus Dan Interferon
26/37
ANTI RETROVIRUS6 NNRTI 6 N'! "+ n
• M'%+n $,' %'"9+ 8 '%'"9+ +.+ $ t#$ + *$t'" % t', +t %+t+n n*n $# t"+=tHIV
8/15/2019 Antivirus Dan Interferon
27/37
ANTI RETROVIRUS6 NNRTI 6 E-+! "'n/
• M'%+n $,' %'"9+ 8 S+,+ .'n;+n n'! "+! n• R'$ $t'n$ 8 D $' + %+n * '& ,#t+$ +.+ RT %*.*n 100 1 1 17• S '%t"#, +%t ! t+$ 8 HIV 1• In. %+$ 8 In-'%$ HIV< 1 .+ +, %*, n+$ .'n;+n +nt HIV + nn:+
t'"#t+,+ NRTI .+n NtRTI7• D*$ $ 8 P'"*"+ 00,; &+" (1>$'&+" t+ 't 00,;) $' + %n:+
$' ' #, t .#" #nt#% ,'n;#"+n; '-'% $+, n; SSP n:+77E-'% $+, n; 8 S+% t %' + + #$ n; , , #"#% $# t'"%*n$'nt"+$ .+n "#+, 7
8/15/2019 Antivirus Dan Interferon
28/37
S',#+ PI '%'"9+.'n;+n =+"+ '" %+t+n
$'=+"+ "'!'"$ '
.'n;+n $ t#$ +%t - HIVJ "*t'+$'7
HIV< "*t'+$' $+n;+t'nt n; #nt#%
n-'%t ! t+$ ! "#$ .+n
'n; ' +$+n* "*t' n ! "#$7
H+ n ,'n:' + %+t'"&+, +tn:+
'n; ' +$+n* ' t .+ "'%#$! "#$ * '& 'n/ ,"*t'+$' $'& n;;+
.+ +t ,'n;&+, +t
,+t#"+$ ! "#$ ,+%$' +%+n ,'n;&+$ %+"t %' ! "#$ :+,+t#" .+n t .+%
! "# 'n7
ANTI RETROVIRUS6 PI
8/15/2019 Antivirus Dan Interferon
29/37
ANTI RETROVIRUS6 PI 6 S+%# n+! "
• MK8 S+%# n+! " '%'"9+ +.+ t+&+ t"+n$ $ ,'"# +%+n HIV "*t'+$'' t .*, ,'t = n& t*"7
• R'$ $t'n$ 8T'"&+.+ $+%# n+! " . $' + %+n * '& ,#t+$ +.+ 'n/ ,"*t'+$' t'"9+. "'$ $t'n$ $ +n; .'n;+n PI + nn:+7
• S '%t"#, +%t ! t+$ 8 HIV (1 2)•
In. %+$ 8 In-'%$ HIV .+ +, %*, n+$ .'n;+n +nt HIV + n ( NRTI .+n' '"+ + PI $' '"t " t*n+! ")7• D*$ $ 8 P'" *"+ 3 00,; &+" ( %+ $# 200,; $*-t %+ $# 3 > $'&+" )
+t+# 1 00,; &+" (3 &+". ;' =+ $# ' 3 > $'&+" ) . '" %+n '"$+,+.'n;+n ,+%+n+n +t+# $+, + .'n;+n 2 9+, $'t' +& ,+%+n 'n;%+ 7
• E-'% $+, n; 8D +"' ,#+ n:'" + .*,'n7
8/15/2019 Antivirus Dan Interferon
30/37
8/15/2019 Antivirus Dan Interferon
31/37
ANTI RETROVIRUS6 Viral entry inhibitor
En-#! "t . ,'"# +%+n * +t '"t+,+ :+n; ,+$#% %' .+ +, ;* *n;+n VIRALENTRY INHI ITOR7
O +t n '%+"9+ .'n;+n =+"+ ,'n;&+, +t -#$ ! "#$ %' $' 7
S' + n 'n-#! t . B $ % +, $++t n $'.+n; '"+.+ .+ +, $t#.: % n $7
O +t n '%'""9+ .'n;+n =+"+ ,'n;&+, +t ,+$#%+n HIV %' $' ,' + #"'$' t*" > R47
8/15/2019 Antivirus Dan Interferon
32/37
• M'%+n $,' %'"9+ 8 M'n;&+, +t ,+$#%n:+ HIV
8/15/2019 Antivirus Dan Interferon
33/37
INTERAKSI O
8/15/2019 Antivirus Dan Interferon
34/37
' '"+ + Int'"+%$ O +t Ant "'t"*! "+ .+n+nt+"+ * +t Ant "'t"*! "+ .';+n O +t + n
8/15/2019 Antivirus Dan Interferon
35/37
' '"+ + Int'"+%$ O +t Ant "'t"*! "+ .+n+nt+"+ * +t Ant "'t"*! "+ .';+n O +t + n
8/15/2019 Antivirus Dan Interferon
36/37
' '"+ + Int'"+%$ O +t Ant "'t"*! "+ .+n+nt+"+ * +t Ant "'t"*! "+ .';+n O +t + n
8/15/2019 Antivirus Dan Interferon
37/37
SEKIAN DAN TERIMA KA