MANIA-- STATE OF ELEVATED MOOD & PSYCHOMOTOR ACCELERATION,
WITH EXCESS CATHECHOLAMINES ACTIVITY
TREATMENT: LITHIUM CARBONATE
INDICATIONS: BIPOLAR DISORDERS
THYROTOXICOSISINAPPROPRIATE ADH SECRETION
ABSORPTION : virtually complete within 6 -8 hrs; peak plasma levels in 30 min to 2 hrs
DISTRIBUTION: in total body water; slow entry into intracellular compartment. No protein binding
METABOLISM: NoneEXCRETION: virtually entirely in urine;
plasma half life is about 20 hours
Memblok jalur IP3 deplesi PIP2 membran menurunkan aksi transmittornya sebagai second messenger
1. CNS EFFECTS: dizziness, mild ataxia2. NEUROMUSCULAR EFECTS: fine tremors3. CVS EFFECTS: ventricular arrythmias4. GIT EFFECTS: nausea, vomiting,
diarrhea5. GUT EFFECTS: polyuria6. ENDOCRINE EFFECTS: hypothyroidism7. ALLERGIC REACTION: pruritus, rash8. OVERDOSE TOXICITY: vomiting, decrease
consciousness and seizures
A. MARKED DEHYDRATION OR SODIUM DEPLETION
B. SIGNIFICANT RENAL OR CARDIAC DISEASES
C. PREGNANCYD. RENAL CONCENTRATION ABILITY Nephrogenic diabetes insipidus with
polyuria
A. THIAZIDE DIURETICS: DECREASE RENAL CLEARANCE OF LITHIUM
B. NSAID: DECREASE LITHIUM CLEARANCEC. ANTIPYSCHOTIC AGENTS: INCREASE NEUROTOXICITY