A Short Introduction To Platelet Rich Plasma Therapy
Blood Components
• Blood Components -93 % RBCs -6 % Platelets -1 % WBCs -Plasma(Liquid Component) • PRP - 94 % Platelets and Plasma - 5 % WBCs
Function of Blood Cells
Leukocytes ;Infection Removal Bacteria
Erythrocytes;Oxygen Transport
Platelets;Blood clotting and wound healing.
Platelets
• Platelets derived from megokaryocytes• Important in Hemostasis/Clotting• Platelets are normally activated during the inflammatory phase to begin healing• Role in the normal healing response via the
secrection of local growth factors• Growth factors released by platelets recruit
reparative cells and augment soft-tissue repair
What Is PRP
Platelet-rich plasma (PRP) is blood plasma that has been enriched with platelets. As a concentrated source of autologous platelets, PRP contains (and releases through degranulation) several different growth factors and other cytokines that stimulate healing of bone and soft tissue.
PRP Application Areas
• Orthopedic and Traumatology• Maxillo-Facial Surgery• Plastic/Reconstructive Surgery• Cardiac Surgery• Cosmetic Surgery• General Surgery• Sports Medicine• Hair Transplantation• Skin Rejuvanation
Platelet Growth Factors
Growth Factor
Transforing Growth Factor –BetaTGF-β
Basic Fibroblast Growth Factor,bFGF
Epidermal Growth FactorEGF
Vascular Endothelial Growth FactorVEGF
Connective Tissue Growth FactorCTGF
Sources
Platelets,extra cellular matrix of bone,Cartilage matrix,activated TH cells and natural killer cells,macrophages/monocytesAnd neutrophils.
Platelets,macrophages,mesenchymal cells,chondrocytes,osteoblasts
Platelets,macrophages,monocytes
Platelets,endothelial cells
Platelets through endocytosis from extra-Cellular environment in bone marrow.
Action of PRP Growth Factors
Healing Cascade
Platelet Count
Normal Platelet Count Concentrated Platelet Count
Cellular Factors İn Wound Healing
Benefits of PRP in the Healing Cascade
Easy PRP Kit
Advantages
• Easy to use• High concentrated PRP• Buffy Coat• Cost Effective• Simple Operation• No Contamination by Pathogens• Convenient for Office use
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