INTERNAL MEDICINE
Parkinson's disease
Def: Parkinson's disease is a degenerative disorder of
the central nervous system that often impairs the sufferer's motor skills, speech, and other functions.
Parkinson's disease
Causes: Idiopathic Drugs- reserpine, tetrabenazine Toxins- manganese, carbomonoxide Viral infection- post encephalitic condition Truma- repeated head injury Rarely neurosyphilis
Parkinson's disease
Clinical feature: Trembling of hands, arms, legs, jaw and face Stiffness of the arms, legs and trunk Slowness of movement (bradykinesia) Poor balance and coordination
Parkinson's disease
Investigation: Serological test for syphilis CT
Parkinson's disease
Management: A)Any identifiable causes should be treated B)Drug therapy- Anticholinergic agent- Benzhexol 1-5 mg 8 hrly or
Phenadrine 50-100 mg 8 hrly Selegiline 10 mg in morning L-dopa+carbidopa 4:1 Bromocriptine(Dopamine receptor agonist)
Parkinson's disease
Management: C)Surgery- stereotatic thalamotomy D)Physiotherapy E)Rehabilitation