5-HT ReceptorSerotonin Receptor 5-hydroxytryptamine Receptor
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs)found in the central and peripheral nervous systems Type 5-HT1 5-HT2 5-HT3 5-HT4 5-HT5 5-HT6 5-HT7 They mediate bothexcitatory and inhibitory neurotransmission The serotonin receptors are activated by the neurotransmitter serotonin which acts astheir natural ligand The serotonin receptors modulate the release of many neurotransmitters as well as many hormones Theserotonin receptors influence various biological and neurological processes such as aggression anxiety appetite cognitionlearning memory mood nausea sleep andthermoregulation The serotonin receptors are the target of a variety of pharmaceuticaldrugs including many antidepressants antipsychotics anorecticsantiemetics gastroprokinetic agents antimigraine agentshallucinogens and entactogens
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5-HT Receptor Antagonists Agonists Inhibitors Modulators amp Activators
(4E)-SUN9221Cat No HY-U00367
(4E)-SUN9221 is a potent antagonist of and withα1-adrenergic receptor 5-HT2 receptor
antihypertensive and anti-platelet aggregationactivities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(R)-Mirtazapine ((R)-Org3770 (R)-6-Azamianserin) Cat No HY-B0352B
(R)-Mirtazapine ((R)-Org3770) is a R(minus)-enantiomerof Mirtazapine with antinociceptive properties inan animal model of acute thermal nociception(R)-Mirtazapine is a antagonist5-HT receptor3
(R)-Mirtazapine is mainly metabolized by CYP3A4
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(R)-Mirtazapine D3 ((R)-Org3770 D3 (R)-6-Azamianserin D3) Cat No HY-B0352BS
(R)-Mirtazapine D3 ((R)-Org3770 D3) is a deuteriumlabeled (R)-Mirtazapine (R)-Mirtazapine is aR(minus)-enantiomer of Mirtazapine withantinociceptive properties in an animal model ofacute thermal nociception (R)-Mirtazapine is a
antagonist5-HT receptor3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(R)-Praziquantel D11Cat No HY-126057S
(R)-Praziquantel D11 is the deuterium labeled(R)-Praziquantel (R)-Praziquantel the activeenantiomer of Praziquantel is a partial agonistof the human 5-HT2B receptor (R)-Praziquantelacts as an antischistosomal eutomer
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(RR)-Palonosetron HydrochlorideCat No HY-A0021C
(RR)-Palonosetron Hydrochloride is the activeenantiomer of Palonosetron
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg
(Rac)-Rotigotine hydrochlorideCat No HY-15394
(Rac)-Rotigotine hydrochloride is a racemate ofRotigotine
Purity 9776Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
(Rac)-WAY-161503Cat No HY-103138A
(Rac)-WAY-161503 is a potent selective highlyaffinity agonist with a of 45-HT receptor2C Ki
nM and an EC of 12 nM (Rac)-WAY-16150350
displays higher affinity for 5-HT than 5-HT2C 2A
and 5-HT receptors (Rac)-WAY-161503 has2B
anti-obesity and antidepressant effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
(S)-Mirtazapine ((S)-Org3770 (S)-6-Azamianserin) Cat No HY-B0352A
(S)-Mirtazapine ((S)-Org3770) is a S(+)-enantiomerof Mirtazapine with pronociceptive properties inan animal model of acute thermal nociception(S)-Mirtazapine is a stereoselective 5-HT2
antagonist (S)-Mirtazapine isreceptormetabolized by CYP2D6 and CYP1A2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(S)-Mirtazapine D3 ((S)-Org3770 D3 (S)-6-Azamianserin D3) Cat No HY-B0352AS
(S)-Mirtazapine D3 ((S)-Org3770 D3) is a deuteriumlabeled (S)-Mirtazapine (S)-Mirtazapine is aS(+)-enantiomer of Mirtazapine with pronociceptiveproperties in an animal model of acute thermalnociception(S)-Mirtazapine is a stereoselective
antagonist5-HT receptor2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(Z)-ThiothixeneCat No HY-108324
(Z)-Thiothixene is an antagonist of serotonergic extracted from patent US 20150141345 A1receptor
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
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(plusmn)-Fabesetron hydrochloride ((plusmn)-FK1052) Cat No HY-101638
(plusmn)-Fabesetron hydrochloride ((plusmn)-FK1052) is theracemate of Fabesetron hydrochloride which is apotent and receptor dual antagonist5-HT3 5-HT4
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
2-O-MethylisoliquiritigeninCat No HY-N1745
2-O-Methylisoliquiritigenin isolated from the species up-regulates andArachis 5-HT NE DA
pathways but does not put a veryGABAsignificant effect on ne NE pathway
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine
2-Methylserotonin 2-Me-5-HT) Cat No HY-19358
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is apotent and selective agonist5-HT receptor3
2-Methyl-5-HT is shown to displayanti-depressive-like effects
Purity 9809Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine
hydrochloride 2-Methylserotonin hydrochloride hellip) Cat No HY-19358A
2-Methyl-5-HT hydrochloride(2-Methyl-5-hydroxytryptamine hydrochloride) is apotent and selective agonist5-HT receptor3
2-Methyl-5-HT hydrochloride is shown to displayanti-depressive-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate
2-Methylserotonin maleate 2-Me-HT maleate) Cat No HY-19358B
2-Methyl-5-HT maleate(2-Methyl-5-hydroxytryptamine maleate) is a potentand selective agonist5-HT receptor3
2-Methyl-5-HT maleate is shown to displayanti-depressive-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
3-Hydroxy agomelatineCat No HY-133111
3-Hydroxy agomelatine is a metabolite ofAgomelatine 3-Hydroxy agomelatine is a 5-HT2C
antagonist with an of 32 μM and areceptor IC50
of 18 μMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg
5-Carboxamidotryptamine maleate (5-CT maleate) Cat No HY-100942
5-Carboxamidotryptamine maleate (5-CT maleate) isa potent and5-HT1A 5-HT1B 5-HT1D 5-HT5
agonist5-HT receptors7
Purity gt98Clinical Data No Development ReportedSize 5 mg
5-HT1A modulator 1Cat No HY-100290
5-HT1A modulator 1 displays very high affinitiesfor the and 5HT1A adrenergic α1 dopamine
with s of 2 plusmn03 nM 10 plusmn 3 nMD receptor2 IC50
and 40 plusmn9 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT1A modulator 2 hydrochlorideCat No HY-136621
5-HT1A modulator 2 hydrochloride a derivative of8-OH-DPAT (HY-112061) is a modulator of 5-HT1A
with a of 53 nM for 5-HT bindingKi 1A
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
5-HT2 antagonist 1Cat No HY-U00365
5-HT2 antagonist 1 is a potent antagonist of with weak 5-HT2 receptor α1 adrenoceptor
blocking activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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5-HT2A antagonist 1Cat No HY-U00286
5-HT2A antagonist 1 is a antagonist5-HT2Aextracted from patent US5728835A and JP 10077275-HT2A antagonist 1 may be useful in treatment ofgastrointestinal disorders circulatory disorders
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3 antagonist 1Cat No HY-U00368
5-HT3 antagonist 1 is a potent and selectiveantagonist of serotonin 3 (5-HT3) receptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3 antagonist 2Cat No HY-U00408
5-HT3 antagonist 2 is a receptor5-HT3antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3 antagonist 3Cat No HY-U00322
5-HT3 antagonist 3 (Compound 15b) is ahigh-affinity antagonist 5-HT35-HT3 receptorantagonist 3 binds to 5-HT3 receptors in rat braincortical membranes with of 025 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3-In-1Cat No HY-U00413
5-HT3-In-1 is extracted from patent EP0748807A1compound example 8 It shows inhibition5-HT3activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT67 antagonist 1Cat No HY-101622
5-HT67 antagonist 1 is a multifunctional ligandthat antagonizes and receptors5-HT672A D2without interacting with M1 receptors and hERGchannels
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT7 agonist 1Cat No HY-109527
5-HT7 agonist 1 is a selective 5-HT7 receptoragonist with an of 22293 nM can be usedIC50
for the 5-HT7 receptor related disease such asCNS disorders
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine) Cat No HY-133112
7-Desmethyl-3-hydroxyagomelatine(3-Hydroxy-7-desmethyl agomelatine) a metaboliteof Agomelatine has less activity thanAgomelatine Agomelatine is a melatonergic( and ) agonist and MT1 MT2 serotonergic( ) antagonist5HT2C
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
7-Desmethyl-agomelatineCat No HY-133113
7-Desmethyl-agomelatine is a metabolite ofAgomelatine Agomelatineis a potent agonist atmelatonin receptors (MT1 and MT2) and also is anantagonist of 5-HT2C
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) Cat No HY-15688
8-Hydroxy-DPAT hydrobromide (8-OH-DPAThydrobromide) is a potent and selective 5-HT1A
agonist with a of 819 8-Hydroxy-DPATpIC50
hydrobromide has selectivity of almost 1000 foldfor a subtype of the 5-HT binding site1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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8-OH-DPAT (8-Hydroxy-DPAT) Cat No HY-112061
8-OH-DPAT is a potent and selective agonist5-HTwith a of 819 for 5-HT1A and a of 466 nMpIC50 Ki
for 5-HT7 8-OH-DPAT weakly binds to 5-HT1B (pIC 50
542) 5-HT (pIC lt5)50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
AbaperidoneCat No HY-101619
Abaperidone is a potent antagonist of and 5-HT receptor2A dopamine D receptor2
with s of 62 and 17 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Adoprazine (SLV313) Cat No HY-14782
Adoprazine a potential atypical antipsychoticbearing potent D2 receptor antagonist and 5-HT1Areceptor agonist properties
Purity 9810Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Agomelatine (S-20098) Cat No HY-17038
Agomelatine (S-20098) is a specific agonist of and receptors with s of 01 006MT1 MT2 Ki
012 and 027 nM for CHO-hMT1 HEK-hMT1CHO-hMT2 and HEK-hMT2 respectively
Purity 9877Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Agomelatine (L(+)-Tartaric acid) (S-20098 L(+)-Tartaric acid) Cat No HY-17038B
Agomelatine L(+)-Tartaric acid (S-20098L(+)-Tartaric acid) is a specific agonist of
and receptors with s of 01 006MT1 MT2 Ki
012 and 027 nM for CHO-hMT1 HEK-hMT1CHO-hMT2 and HEK-hMT2 respectively
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Agomelatine hydrochloride (S-20098 hydrochloride) Cat No HY-17038A
Agomelatine hydrochloride (S-20098 hydrochloride)is a specific agonist of and MT1 MT2receptors with s of 01 006 012 and 027 nMKi
for CHO-hMT1 HEK-hMT1 CHO-hMT2 and HEK-hMT2respectively
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
AlmotriptanCat No HY-B0383A
Almotriptan is a 5-HT1B1D-receptor agonist usedto treat migraine
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Almotriptan malate (PNU180638) Cat No HY-B0383
Almotriptan Malate is a 5-HT1B1D-receptor agonistused to treat migraine
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Alniditan (Alnitidan) Cat No HY-101698
Alniditan is a potent 5-HT receptors1B1D
agonist with of 17 and 13 nM in HEK293IC50
cells and value of 896 and 940 forpKi
5-HT receptors respectively1B1D
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Alosetron (GR 68755 GR 68755X) Cat No HY-70050A
Alosetron (GR 68755) is a potent and highlyselective serotonin antagonist5-HT3 receptorAlosetron is used for the research of irritablebowel syndrome (IBS)
Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 25 mg
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Alosetron ((Z)-2-butenedioate) (GR 68755
((Z)-2-butenedioate) GR 68755X ((Z)-2-butenedioate)) Cat No HY-70050B
Alosetron (GR 68755) (Z)-2-butenedioate is apotent and highly selective serotonin 5-HT3
antagonist Alosetron (Z)-2-butenedioatereceptoris used for the research of irritable bowelsyndrome (IBS)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Alosetron (Hydrochloride(1X)) (GR 68755
(Hydrochloride(1X)) GR 68755X (Hydrochloride(1X))) Cat No HY-70050
Alosetron (GR 68755) Hydrochloride(1X) is apotent and highly selective serotonin 5-HT3
antagonist Alosetron Hydrochloride(1X)receptoris used for the research of irritable bowelsyndrome (IBS)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Alosetron Hydrochloride (GR 68755C GR 68755 Hydrochloride
GR 68755X Hydrochloride) Cat No HY-70050C
Alosetron Hydrochloride (GR 68755C) is a potentand highly selective serotonin 5-HT3 receptorantagonist Alosetron Hydrochloride is used forthe research of irritable bowel syndrome (IBS)
Purity 9979Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Alprenolol ((RS)-Alprenolol dl-Alprenolol) Cat No HY-B1517
Alprenolol is a non-selective beta blocker as wellas 5-HT1A receptor antagonist The reference foradministration is 10 mgkg
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg
Alprenolol hydrochloride ((RS)-Alprenolol hydrochloride
dl-Alprenolol hydrochloride) Cat No HY-B1517A
Alprenolol (hydrochloride) is a non-selective betablocker as well as 5-HT1A receptor antagonist Thereference for administration is 10 mgkg
Purity 9958Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Alverine citrate (NSC 35459) Cat No HY-B0500
Alverine citrate is a receptor5-HT1A
antagonist with an of 101 nMIC50
Purity 9943Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Amitriptyline hydrochlorideCat No HY-B0527A
Amitriptyline hydrochloride is an inhibitor of andserotonin reuptake transporter (SERT)
with snoradrenaline reuptake transporter (NET) Ki
of 345 nM and 133 nM for human SERT and NETrespectively
Purity 9956Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ansofaxine hydrochloride (LY03005 LPM570065) Cat No HY-U00096
Ansofaxine hydrochloride (LY03005 LPM570065) is atriple reuptake inhibitor inhibits serotonin
and reuptake with dopamine norepinephrine IC50
values of 723 491 and 763 nM respectively
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 20 mg 50 mg 100 mg
AP521Cat No HY-100166
AP521 is an agonist of human 5-HT receptor1A
with an of 94 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AR-A 2 (AR-A 000002) Cat No HY-107018
AR-A 2 is a selective 5-HT receptor1B
antagonist with high affinity to guinea pigcortex and recombinant guinea pig5HT1B1D
( =024 and 047 nM) and with5-HT receptors1B Ki
10-fold lower affinity to guinea pig 5-HT1D
( 5 nM) and shows an ofhellipreceptor Ki EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Aripiprazole (OPC-14597) Cat No HY-14546
Aripiprazole (OPC-14597) is a human 5-HT1Areceptor partial agonist with a Ki of 42 nM
Purity 9998Clinical Data LaunchedSize 100 mg 200 mg 500 mg 1 g
ArotinololCat No HY-122537A
Arotinolol is a nonselective αβ-adrenergic blocker and a vasodilating β-blockerreceptor
Arotinolol also shows potency for inhibiting thebinding of the radioligand I-ICYP to125
-serotonergic receptor sites5HT1B
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
AS19Cat No HY-103142
AS19 is a potent selective 5-HT receptor7
agonist with an value of 083 nM and a ofIC50 Ki
06 nM AS19 is selective for over5-HT7
5-HT 5-HT 5-HT and 5-HT receptors1A 1B 1D 5A
( s = 897 nM 490 nM 66 nM and 985 nMKi
respectively)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Asenapine (Org 5222) Cat No HY-10121
Asenapine is an antagonist of serotonin receptors(5-HT 5-HT 5-HT 5-HT 5-HT )2A 2B 2C 6 7
(α α α α )adrenoceptors 1 2A 2B 2C
(D D D ) anddopamine receptors 2 3 4
(H H ) with shistamine receptors 1 2 pKi
of 84-105 89-95 89-94 andhellip
Purity 9881Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine hydrochlorideCat No HY-16567
Asenapine hydrochloride an antipsychotic is a (1A 1B 2A 2B 2C 5A 6 7) and 5-HT
receptor antagonist withDopamine (D D D )2 3 4
values of 003-40 nM for 5-HT and 13 042Ki
11 nM for Dopamine receptor respectively
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine maleate (Org 5222 maleate) Cat No HY-11100
Asenapine maleate is a (1A 1B 2A 2B 2C5-HT5A 6 7) and antagonist with values ofD2 Ki
003-40 nM 13nM respectively and anantipsychotic
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg
AsimilobineCat No HY-N7512
Asimilobine is an aporphine isoquinoline alkaloidisolated from plant species of Magnolia obobataThun Asimilobine is a biosynthesisdopamineinhibitor and a antagonistserotonergic receptorAsimilobine shows an andantimalarialanti-cancer activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AVN-492Cat No HY-101924
AVN-492 is a very specific and highly-selectiveantagonist with picomolar affinity to 5-HT6R( =91 pM)Ki
Purity 9949Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Azasetron hydrochloride (Y-25130 hydrochloride) Cat No HY-B0068
Azasetron (Y-25130) hydrochloride a benzamidederivative is a potent and selective 5-HT3receptor antagonist Azasetron is used in thestudy for Chemotherapy-induced nausea and vomiting(CINV)
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Befiradol (NLX-112 F13640) Cat No HY-14785
Befiradol (NLX-112) is a selective 5-HT1Areceptor agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Befiradol hydrochloride (NLX-112 hydrochloride F 13640 hydrochloride) Cat No HY-14785A
Befiradol hydrochloride (NLX-112 hydrochloride) isa selective receptor agonist5-HT1A
Purity 9922Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Bemesetron (MDL 72222) Cat No HY-B1541
Bemesetron (MDL 72222) is a selective 5-HT3
antagonist with an of 033 nMreceptor IC50
Neuroprotective effect
Purity gt990Clinical Data No Development ReportedSize 10 mg
BGC20-761Cat No HY-21995
BGC20-761 is a selecvtive and 5-HT6 dopamine antagonist (human receptor valuesreceptor Ki
5-HT6 (20 nM) 5-HT2A (69 nM) D2 (140 nM)BGC20-761 can enhance long-term memory BGC20-761has potential utility as an antipsychotic agent
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin (AD-5423) Cat No HY-13575
Blonanserin (AD-5423) is a potent and orallyactive ( =0812 nM)5-HT2A Ki
and (dopamine D2enspreceptor Ki
=0142 nM) antagonist
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 100 mg
Blonanserin D5 (AD-5423 D5) Cat No HY-13575S1
Blonanserin D5 (AD-5423 D5) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin D8 (AD-5423 D8) Cat No HY-13575S
Blonanserin D8 (AD-5423 D8) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brexpiprazole (OPC-34712) Cat No HY-15780
Brexpiprazole (OPC-34712) an atypicalantipsychotic drug is a partial agonist of human
and with s of 0125-HT1A dopamine receptor Ki
nM and 03 nM respectively Brexpiprazole is alsoa receptor antagonist with a of 0475-HT2A Ki
nM
Purity 9940Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
Brexpiprazole S-oxide (DM-3411) Cat No HY-133152
Brexpiprazole S-oxide (DM-3411) is a mainmetabolite of Brexpiprazole and is metabolized bycytochrome P450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 5 mg
Brexpiprazole S-oxide D8 (DM-3411 D8) Cat No HY-133152S
Brexpiprazole S-oxide D8 (DM-3411 D8) is adeuterium labeled Brexpiprazole S-oxideBrexpiprazole S-oxide is a main metabolite ofBrexpiprazole and is metabolized by cytochromeP450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brilaroxazine (RP5063) Cat No HY-109112
Brilaroxazine (RP5603) is a potent and orallyactive multimodal dopamine (DA)serotonin
modulator(5-HT)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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BRL 54443Cat No HY-13221
BRL 54443 is a potent receptor agonist5-HT1E1F
( values are 11 nM and 07 nM respectively)Ki
displays gt 30-fold selectivity over other 5-HTand dopamine receptors
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
BRL-15572 dihydrochlorideCat No HY-13200
BRL-15572 dihydrochloride is a selectiveantagonist of displays high affinity forh5-HT1D
BRL-15572 dihydrochlorideh5-HT1D receptorscould be useful pharmacological agents tocharacterise mediated responses5-HT1D receptor
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Bromperidol (R-11333) Cat No HY-B0901
Bromperidol is a butyrophenone derivative is apotent and long-acting neuroleptic used as anantipsychotic in the treatment of schizophrenia
Purity 9802Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Buspirone hydrochlorideCat No HY-B1115
Buspirone hydrochloride is an anxiolyticpsychotropic drug is used to treat generalizedanxiety disorder (GAD)
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Cariprazine (RGH-188) Cat No HY-14763
Cariprazine is a novel antipsychotic drugcandidate that exhibits high affinity for the D3
( =0085 nM) and ( =049 nM) receptors andKi D2 Ki
moderate affinity for the receptor5-HT1A
( =26 nM)Ki
Purity 9935Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg
Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A
Cariprazine hydrochloride is a novel antipsychoticdrug candidate that exhibits high affinity for the
( =0085 nM) and ( =049 nM)D3 Ki D2 Ki
receptors and moderate affinity for the 5-HT1A
receptor ( =26 nM)Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 50 mg
CART(62-76)(humanrat)Cat No HY-P1303
CART(62-76)(humanrat) is a neuropeptide (62-76residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
CART(62-76)(humanrat) TFACat No HY-P1303A
CART(62-76)(humanrat) TFA is a neuropeptide(62-76 residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Chlorpromazine D6 hydrochlorideCat No HY-B0407AS
Chlorpromazine D6 hydrochloride is the deuteriumlabeled Chlorpromazine Chlorpromazine is aninhibitor of dopamine receptor 5-HT receptorpotassium channel sodium channel
Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
Chlorpromazine hydrochlorideCat No HY-B0407A
Chlorpromazine hydrochloride is an antagonist ofthe dopamine D2 5HT2A potassium channeland Chlorpromazine binds with D2sodium channeland 5HT2A with s of 363 nM and 83 nMKi
respectively
Purity 9990Clinical Data LaunchedSize 500 mg 1 g 5 g
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Cinanserin hydrochloride (SQ 10643) Cat No HY-100943
Cinanserin hydrochloride (SQ 10643) is a potentselective and highly affinity 5-HT receptor2
antagonist with a of 41 nM CinanserinKi
hydrochloride has a much higher binding affinityfor the than for the 5-HT receptor (5-HT2 1 Ki
of 3500 nM)
Purity 9974Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
cis-(Z)-Flupentixol dihydrochloride (cis-(Z)-Flupenthixol dihydrochloride) Cat No HY-15856
cis-(Z)-Flupentixol dihydrochloride is a potentand selective antagonist withDA D1D2 receptor
values of 038 nM and 7 nM for D2 receptor andKi
respectively5-HT2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
cis-Urocanic acid ((Z)-Urocanic acid cis-UCA) Cat No HY-113008A
cis-Urocanic acid is a agonist5-HT2A receptorcis-Urocanic acid binds to with5-HT receptorrelatively high affinity ( =46 nM)Kd
cis-Urocanic acid is an immune modulator thatinduces immunosuppression by binding to the 5-HT2Areceptor
Purity 9992Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg
Cisapride (R 51619 (plusmn)-Cisaprid) Cat No HY-14149
Cisapride(R 51619) is a nonselective 5-HT4receptor agonist it is also a potent hERGpotassium channel inhibitor
Purity 9972Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073
Clocapramine is an antagonist of the D2
5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A
Clocapramine hydrochloride hydrate is anantagonist of the and D2 5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
CP-809101 hydrochlorideCat No HY-15543A
CP-809101 hydrochloride is a potent and selective5-HT2C receptor agonist with pEC50 of996719681 for human 5-HT2C5-HT2B5-HT2Areceptors respectively
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
CyamemazineCat No HY-14264
Cyamemazine is a neuroleptic agent that containsthe phenothiazine chromophore Cyamemazine isoften used as an anxiolytic Cyamemazine is apotent ( of 12 nM) ( = 155-HT3 Ki 5-HT2A Ki
nM) and ( of 75 nM) receptors5-HT2C Ki
antagonist with antipsychotic activity
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Cyclobenzaprine hydrochloride (MK130 hydrochloride) Cat No HY-B0740
Cyclobenzaprine hydrochloride (MK130hydrochloride) is a skeletal muscle relaxant and acentral nervous system (CNS) depressant Target5-HT Receptor 2A Cyclobenzaprine hydrochloride isa skeletal muscle relaxant and a central nervoussystem (CNS) depressant
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Cyproheptadine hydrochlorideCat No HY-B0366A
Cyproheptadine hydrochloride is a 5-HT2A
antagonist with antidepressant andreceptorantiserotonergic effects Cyproheptadinehydrochloride has antiplatelet andthromboprotective activities
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg 1 g
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Cyproheptadine hydrochloride sesquihydrateCat No HY-B1165
Cyproheptadine hydrochloride sesquihydrate is anantihistamine and is an antagonist of serotoninand histamine2
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
Dehydroaripiprazole (OPC-14857 DM-14857) Cat No HY-100665
Dehydroaripiprazole (OPC-14857) is an activemetabolite of Aripiprazole Aripiprazole is anantipsychotic agent and is metabolized by CYP3A4and CYP2D6 forming mainly DehydroaripiprazoleDehydroaripiprazole has with antipsychoticactivity equivalent to Aripiprazole
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Deramciclane (EGIS-3886) Cat No HY-101630
Deramciclane has a high affinity for and5-HT2A
receptors it acts as an antagonist at5-HT2C
both receptor subtypes and has inverse agonistproperties at the 5-HT receptors without direct2C
stimulatory agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Dihydroergotamine mesylateCat No HY-B0670A
Dihydroergotamine mesylate is an ergot alkaloidused to treat migraines
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Dolasetron (MDL-73147) Cat No HY-B0750
Dolasetron(MDL-73147) is a serotonin 5-HT3receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
Dolasetron Mesylate (MDL-73147EF) Cat No HY-B0750A
Dolasetron Mesylate (MDL-73147EF) is a serotonin5-HT3 receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) Cat No HY-B0750B
Dolasetron Mesylate hydrate (MDL-73147EF hydrate)is a serotonin 5-HT3 receptor antagonist used totreat nausea and vomiting following chemotherapy
Purity gt990Clinical Data LaunchedSize 100 mg 200 mg
DonitriptanCat No HY-106157
Donitriptan is a potent high efficacy agonist ats with s of 94 and 935-HT receptor1B1D pKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eletriptan hydrobromide (Eletriptan HBr) Cat No HY-A0010
Eletriptan HBr is a selective 5-HT1B and 5-HT1Dreceptor agonist with Ki of 092 nM and 314 nMrespectively
Purity 9513Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Eltoprazine (DU 28853) Cat No HY-16687
Eltoprazine(DU28853) is a serenic orantiaggressive agent which as an agonist at the5-HT1A and 5-HT1B receptors and as an antagonistat the 5-HT2C receptor
Purity gt950Clinical Data Phase 2Size 1 mg 5 mg
wwwMedChemExpresscom 11
Eltoprazine hydrochloride (DU 28853 hydrochloride) Cat No HY-16687A
Eltoprazine hydrochloride (DU 28853 hydrochloride)is a serenic or antiaggressive agent which as anagonist at the 5-HT1A and 5-HT1B receptors and asan antagonist at the 5-HT2C receptor
Purity 9985Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
EMD 56551Cat No HY-19134
EMD 56551 is a potent and selective 5-HT1A agonist EMD 56551 exerts anxiolyticreceptor
activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eplivanserin (SR-46349) Cat No HY-10792
Eplivanserin is a potent selective and orallyavailable antagonist with an5-HT receptor2
of 58 nM in rat cortical membrane and aIC50
of 114 nMKd
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Eplivanserin (mixture) (SR-46349 (mixture)) Cat No HY-10792A
Eplivanserin mixture (SR-46349 mixture) is aselective inhibitor and aserotonin reuptake
antagonist extracted from5-HT receptor2A
patent WO 2005002578 A1
Purity 9995Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Eptapirone (F 11440) Cat No HY-19946
Eptapirone (F11440) is a potent selective highefficacy 5-HT1A receptor agonist with markedanxiolytic and antidepressant potential
Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
F-15599 (NLX-101) Cat No HY-19863
F-15599 is a highly selective G-protein biased agonist with of 34 nM5-HT1A receptor Ki
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Fabesetron (FK1052 free base) Cat No HY-105201
Fabesetron (FK1052) is an orally active 5-HT3
antagonist with receptor 5-HT receptor4
antagonistic activity Fabesetron (FK1052) can beused in the study for both acute and delayedemesis induced by cancer chemotherapy
Purity 9572Clinical Data No Development ReportedSize 1 mg 5 mg
Facinicline hydrochloride (RG3487 hydrochloride) Cat No HY-108057A
Facinicline hydrochloride (RG3487 hydrochloride)is an orally active partialnicotinic α7 receptoragonist with a of 6 nM for α7 human nAChRKi
Facinicline hydrochloride (RG3487 hydrochloride)improves cognition and sensorimotor gating inrodents
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Fananserin (RP 62203) Cat No HY-103104
Fananserin (RP 62203) is an orally bioavailablepotent and selective 5-hydroxytryptamine2
receptor antagonist with a of 037(5-HT )2 Ki
nM for the rat 5-HT receptor2A
Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
FlesinoxanCat No HY-121653
Flesinoxan is a hypotensive agent and a potenthigh affinity and selective5-hydroxytryptamine1A (5-HT1A) receptoragonist with an value of 24 nM FlesinoxanEC50
also has effective anxiolyticantidepressanteffects
Purity 9907Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 1 g
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Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
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LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
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Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
5-HT Receptor Antagonists Agonists Inhibitors Modulators amp Activators
(4E)-SUN9221Cat No HY-U00367
(4E)-SUN9221 is a potent antagonist of and withα1-adrenergic receptor 5-HT2 receptor
antihypertensive and anti-platelet aggregationactivities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(R)-Mirtazapine ((R)-Org3770 (R)-6-Azamianserin) Cat No HY-B0352B
(R)-Mirtazapine ((R)-Org3770) is a R(minus)-enantiomerof Mirtazapine with antinociceptive properties inan animal model of acute thermal nociception(R)-Mirtazapine is a antagonist5-HT receptor3
(R)-Mirtazapine is mainly metabolized by CYP3A4
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(R)-Mirtazapine D3 ((R)-Org3770 D3 (R)-6-Azamianserin D3) Cat No HY-B0352BS
(R)-Mirtazapine D3 ((R)-Org3770 D3) is a deuteriumlabeled (R)-Mirtazapine (R)-Mirtazapine is aR(minus)-enantiomer of Mirtazapine withantinociceptive properties in an animal model ofacute thermal nociception (R)-Mirtazapine is a
antagonist5-HT receptor3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(R)-Praziquantel D11Cat No HY-126057S
(R)-Praziquantel D11 is the deuterium labeled(R)-Praziquantel (R)-Praziquantel the activeenantiomer of Praziquantel is a partial agonistof the human 5-HT2B receptor (R)-Praziquantelacts as an antischistosomal eutomer
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(RR)-Palonosetron HydrochlorideCat No HY-A0021C
(RR)-Palonosetron Hydrochloride is the activeenantiomer of Palonosetron
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg
(Rac)-Rotigotine hydrochlorideCat No HY-15394
(Rac)-Rotigotine hydrochloride is a racemate ofRotigotine
Purity 9776Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
(Rac)-WAY-161503Cat No HY-103138A
(Rac)-WAY-161503 is a potent selective highlyaffinity agonist with a of 45-HT receptor2C Ki
nM and an EC of 12 nM (Rac)-WAY-16150350
displays higher affinity for 5-HT than 5-HT2C 2A
and 5-HT receptors (Rac)-WAY-161503 has2B
anti-obesity and antidepressant effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
(S)-Mirtazapine ((S)-Org3770 (S)-6-Azamianserin) Cat No HY-B0352A
(S)-Mirtazapine ((S)-Org3770) is a S(+)-enantiomerof Mirtazapine with pronociceptive properties inan animal model of acute thermal nociception(S)-Mirtazapine is a stereoselective 5-HT2
antagonist (S)-Mirtazapine isreceptormetabolized by CYP2D6 and CYP1A2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(S)-Mirtazapine D3 ((S)-Org3770 D3 (S)-6-Azamianserin D3) Cat No HY-B0352AS
(S)-Mirtazapine D3 ((S)-Org3770 D3) is a deuteriumlabeled (S)-Mirtazapine (S)-Mirtazapine is aS(+)-enantiomer of Mirtazapine with pronociceptiveproperties in an animal model of acute thermalnociception(S)-Mirtazapine is a stereoselective
antagonist5-HT receptor2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(Z)-ThiothixeneCat No HY-108324
(Z)-Thiothixene is an antagonist of serotonergic extracted from patent US 20150141345 A1receptor
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
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(plusmn)-Fabesetron hydrochloride ((plusmn)-FK1052) Cat No HY-101638
(plusmn)-Fabesetron hydrochloride ((plusmn)-FK1052) is theracemate of Fabesetron hydrochloride which is apotent and receptor dual antagonist5-HT3 5-HT4
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
2-O-MethylisoliquiritigeninCat No HY-N1745
2-O-Methylisoliquiritigenin isolated from the species up-regulates andArachis 5-HT NE DA
pathways but does not put a veryGABAsignificant effect on ne NE pathway
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine
2-Methylserotonin 2-Me-5-HT) Cat No HY-19358
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is apotent and selective agonist5-HT receptor3
2-Methyl-5-HT is shown to displayanti-depressive-like effects
Purity 9809Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine
hydrochloride 2-Methylserotonin hydrochloride hellip) Cat No HY-19358A
2-Methyl-5-HT hydrochloride(2-Methyl-5-hydroxytryptamine hydrochloride) is apotent and selective agonist5-HT receptor3
2-Methyl-5-HT hydrochloride is shown to displayanti-depressive-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate
2-Methylserotonin maleate 2-Me-HT maleate) Cat No HY-19358B
2-Methyl-5-HT maleate(2-Methyl-5-hydroxytryptamine maleate) is a potentand selective agonist5-HT receptor3
2-Methyl-5-HT maleate is shown to displayanti-depressive-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
3-Hydroxy agomelatineCat No HY-133111
3-Hydroxy agomelatine is a metabolite ofAgomelatine 3-Hydroxy agomelatine is a 5-HT2C
antagonist with an of 32 μM and areceptor IC50
of 18 μMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg
5-Carboxamidotryptamine maleate (5-CT maleate) Cat No HY-100942
5-Carboxamidotryptamine maleate (5-CT maleate) isa potent and5-HT1A 5-HT1B 5-HT1D 5-HT5
agonist5-HT receptors7
Purity gt98Clinical Data No Development ReportedSize 5 mg
5-HT1A modulator 1Cat No HY-100290
5-HT1A modulator 1 displays very high affinitiesfor the and 5HT1A adrenergic α1 dopamine
with s of 2 plusmn03 nM 10 plusmn 3 nMD receptor2 IC50
and 40 plusmn9 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT1A modulator 2 hydrochlorideCat No HY-136621
5-HT1A modulator 2 hydrochloride a derivative of8-OH-DPAT (HY-112061) is a modulator of 5-HT1A
with a of 53 nM for 5-HT bindingKi 1A
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
5-HT2 antagonist 1Cat No HY-U00365
5-HT2 antagonist 1 is a potent antagonist of with weak 5-HT2 receptor α1 adrenoceptor
blocking activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 3
5-HT2A antagonist 1Cat No HY-U00286
5-HT2A antagonist 1 is a antagonist5-HT2Aextracted from patent US5728835A and JP 10077275-HT2A antagonist 1 may be useful in treatment ofgastrointestinal disorders circulatory disorders
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3 antagonist 1Cat No HY-U00368
5-HT3 antagonist 1 is a potent and selectiveantagonist of serotonin 3 (5-HT3) receptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3 antagonist 2Cat No HY-U00408
5-HT3 antagonist 2 is a receptor5-HT3antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3 antagonist 3Cat No HY-U00322
5-HT3 antagonist 3 (Compound 15b) is ahigh-affinity antagonist 5-HT35-HT3 receptorantagonist 3 binds to 5-HT3 receptors in rat braincortical membranes with of 025 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3-In-1Cat No HY-U00413
5-HT3-In-1 is extracted from patent EP0748807A1compound example 8 It shows inhibition5-HT3activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT67 antagonist 1Cat No HY-101622
5-HT67 antagonist 1 is a multifunctional ligandthat antagonizes and receptors5-HT672A D2without interacting with M1 receptors and hERGchannels
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT7 agonist 1Cat No HY-109527
5-HT7 agonist 1 is a selective 5-HT7 receptoragonist with an of 22293 nM can be usedIC50
for the 5-HT7 receptor related disease such asCNS disorders
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine) Cat No HY-133112
7-Desmethyl-3-hydroxyagomelatine(3-Hydroxy-7-desmethyl agomelatine) a metaboliteof Agomelatine has less activity thanAgomelatine Agomelatine is a melatonergic( and ) agonist and MT1 MT2 serotonergic( ) antagonist5HT2C
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
7-Desmethyl-agomelatineCat No HY-133113
7-Desmethyl-agomelatine is a metabolite ofAgomelatine Agomelatineis a potent agonist atmelatonin receptors (MT1 and MT2) and also is anantagonist of 5-HT2C
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) Cat No HY-15688
8-Hydroxy-DPAT hydrobromide (8-OH-DPAThydrobromide) is a potent and selective 5-HT1A
agonist with a of 819 8-Hydroxy-DPATpIC50
hydrobromide has selectivity of almost 1000 foldfor a subtype of the 5-HT binding site1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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8-OH-DPAT (8-Hydroxy-DPAT) Cat No HY-112061
8-OH-DPAT is a potent and selective agonist5-HTwith a of 819 for 5-HT1A and a of 466 nMpIC50 Ki
for 5-HT7 8-OH-DPAT weakly binds to 5-HT1B (pIC 50
542) 5-HT (pIC lt5)50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
AbaperidoneCat No HY-101619
Abaperidone is a potent antagonist of and 5-HT receptor2A dopamine D receptor2
with s of 62 and 17 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Adoprazine (SLV313) Cat No HY-14782
Adoprazine a potential atypical antipsychoticbearing potent D2 receptor antagonist and 5-HT1Areceptor agonist properties
Purity 9810Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Agomelatine (S-20098) Cat No HY-17038
Agomelatine (S-20098) is a specific agonist of and receptors with s of 01 006MT1 MT2 Ki
012 and 027 nM for CHO-hMT1 HEK-hMT1CHO-hMT2 and HEK-hMT2 respectively
Purity 9877Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Agomelatine (L(+)-Tartaric acid) (S-20098 L(+)-Tartaric acid) Cat No HY-17038B
Agomelatine L(+)-Tartaric acid (S-20098L(+)-Tartaric acid) is a specific agonist of
and receptors with s of 01 006MT1 MT2 Ki
012 and 027 nM for CHO-hMT1 HEK-hMT1CHO-hMT2 and HEK-hMT2 respectively
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Agomelatine hydrochloride (S-20098 hydrochloride) Cat No HY-17038A
Agomelatine hydrochloride (S-20098 hydrochloride)is a specific agonist of and MT1 MT2receptors with s of 01 006 012 and 027 nMKi
for CHO-hMT1 HEK-hMT1 CHO-hMT2 and HEK-hMT2respectively
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
AlmotriptanCat No HY-B0383A
Almotriptan is a 5-HT1B1D-receptor agonist usedto treat migraine
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Almotriptan malate (PNU180638) Cat No HY-B0383
Almotriptan Malate is a 5-HT1B1D-receptor agonistused to treat migraine
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Alniditan (Alnitidan) Cat No HY-101698
Alniditan is a potent 5-HT receptors1B1D
agonist with of 17 and 13 nM in HEK293IC50
cells and value of 896 and 940 forpKi
5-HT receptors respectively1B1D
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Alosetron (GR 68755 GR 68755X) Cat No HY-70050A
Alosetron (GR 68755) is a potent and highlyselective serotonin antagonist5-HT3 receptorAlosetron is used for the research of irritablebowel syndrome (IBS)
Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 25 mg
wwwMedChemExpresscom 5
Alosetron ((Z)-2-butenedioate) (GR 68755
((Z)-2-butenedioate) GR 68755X ((Z)-2-butenedioate)) Cat No HY-70050B
Alosetron (GR 68755) (Z)-2-butenedioate is apotent and highly selective serotonin 5-HT3
antagonist Alosetron (Z)-2-butenedioatereceptoris used for the research of irritable bowelsyndrome (IBS)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Alosetron (Hydrochloride(1X)) (GR 68755
(Hydrochloride(1X)) GR 68755X (Hydrochloride(1X))) Cat No HY-70050
Alosetron (GR 68755) Hydrochloride(1X) is apotent and highly selective serotonin 5-HT3
antagonist Alosetron Hydrochloride(1X)receptoris used for the research of irritable bowelsyndrome (IBS)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Alosetron Hydrochloride (GR 68755C GR 68755 Hydrochloride
GR 68755X Hydrochloride) Cat No HY-70050C
Alosetron Hydrochloride (GR 68755C) is a potentand highly selective serotonin 5-HT3 receptorantagonist Alosetron Hydrochloride is used forthe research of irritable bowel syndrome (IBS)
Purity 9979Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Alprenolol ((RS)-Alprenolol dl-Alprenolol) Cat No HY-B1517
Alprenolol is a non-selective beta blocker as wellas 5-HT1A receptor antagonist The reference foradministration is 10 mgkg
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg
Alprenolol hydrochloride ((RS)-Alprenolol hydrochloride
dl-Alprenolol hydrochloride) Cat No HY-B1517A
Alprenolol (hydrochloride) is a non-selective betablocker as well as 5-HT1A receptor antagonist Thereference for administration is 10 mgkg
Purity 9958Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Alverine citrate (NSC 35459) Cat No HY-B0500
Alverine citrate is a receptor5-HT1A
antagonist with an of 101 nMIC50
Purity 9943Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Amitriptyline hydrochlorideCat No HY-B0527A
Amitriptyline hydrochloride is an inhibitor of andserotonin reuptake transporter (SERT)
with snoradrenaline reuptake transporter (NET) Ki
of 345 nM and 133 nM for human SERT and NETrespectively
Purity 9956Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ansofaxine hydrochloride (LY03005 LPM570065) Cat No HY-U00096
Ansofaxine hydrochloride (LY03005 LPM570065) is atriple reuptake inhibitor inhibits serotonin
and reuptake with dopamine norepinephrine IC50
values of 723 491 and 763 nM respectively
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 20 mg 50 mg 100 mg
AP521Cat No HY-100166
AP521 is an agonist of human 5-HT receptor1A
with an of 94 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AR-A 2 (AR-A 000002) Cat No HY-107018
AR-A 2 is a selective 5-HT receptor1B
antagonist with high affinity to guinea pigcortex and recombinant guinea pig5HT1B1D
( =024 and 047 nM) and with5-HT receptors1B Ki
10-fold lower affinity to guinea pig 5-HT1D
( 5 nM) and shows an ofhellipreceptor Ki EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Aripiprazole (OPC-14597) Cat No HY-14546
Aripiprazole (OPC-14597) is a human 5-HT1Areceptor partial agonist with a Ki of 42 nM
Purity 9998Clinical Data LaunchedSize 100 mg 200 mg 500 mg 1 g
ArotinololCat No HY-122537A
Arotinolol is a nonselective αβ-adrenergic blocker and a vasodilating β-blockerreceptor
Arotinolol also shows potency for inhibiting thebinding of the radioligand I-ICYP to125
-serotonergic receptor sites5HT1B
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
AS19Cat No HY-103142
AS19 is a potent selective 5-HT receptor7
agonist with an value of 083 nM and a ofIC50 Ki
06 nM AS19 is selective for over5-HT7
5-HT 5-HT 5-HT and 5-HT receptors1A 1B 1D 5A
( s = 897 nM 490 nM 66 nM and 985 nMKi
respectively)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Asenapine (Org 5222) Cat No HY-10121
Asenapine is an antagonist of serotonin receptors(5-HT 5-HT 5-HT 5-HT 5-HT )2A 2B 2C 6 7
(α α α α )adrenoceptors 1 2A 2B 2C
(D D D ) anddopamine receptors 2 3 4
(H H ) with shistamine receptors 1 2 pKi
of 84-105 89-95 89-94 andhellip
Purity 9881Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine hydrochlorideCat No HY-16567
Asenapine hydrochloride an antipsychotic is a (1A 1B 2A 2B 2C 5A 6 7) and 5-HT
receptor antagonist withDopamine (D D D )2 3 4
values of 003-40 nM for 5-HT and 13 042Ki
11 nM for Dopamine receptor respectively
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine maleate (Org 5222 maleate) Cat No HY-11100
Asenapine maleate is a (1A 1B 2A 2B 2C5-HT5A 6 7) and antagonist with values ofD2 Ki
003-40 nM 13nM respectively and anantipsychotic
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg
AsimilobineCat No HY-N7512
Asimilobine is an aporphine isoquinoline alkaloidisolated from plant species of Magnolia obobataThun Asimilobine is a biosynthesisdopamineinhibitor and a antagonistserotonergic receptorAsimilobine shows an andantimalarialanti-cancer activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AVN-492Cat No HY-101924
AVN-492 is a very specific and highly-selectiveantagonist with picomolar affinity to 5-HT6R( =91 pM)Ki
Purity 9949Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Azasetron hydrochloride (Y-25130 hydrochloride) Cat No HY-B0068
Azasetron (Y-25130) hydrochloride a benzamidederivative is a potent and selective 5-HT3receptor antagonist Azasetron is used in thestudy for Chemotherapy-induced nausea and vomiting(CINV)
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Befiradol (NLX-112 F13640) Cat No HY-14785
Befiradol (NLX-112) is a selective 5-HT1Areceptor agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 7
Befiradol hydrochloride (NLX-112 hydrochloride F 13640 hydrochloride) Cat No HY-14785A
Befiradol hydrochloride (NLX-112 hydrochloride) isa selective receptor agonist5-HT1A
Purity 9922Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Bemesetron (MDL 72222) Cat No HY-B1541
Bemesetron (MDL 72222) is a selective 5-HT3
antagonist with an of 033 nMreceptor IC50
Neuroprotective effect
Purity gt990Clinical Data No Development ReportedSize 10 mg
BGC20-761Cat No HY-21995
BGC20-761 is a selecvtive and 5-HT6 dopamine antagonist (human receptor valuesreceptor Ki
5-HT6 (20 nM) 5-HT2A (69 nM) D2 (140 nM)BGC20-761 can enhance long-term memory BGC20-761has potential utility as an antipsychotic agent
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin (AD-5423) Cat No HY-13575
Blonanserin (AD-5423) is a potent and orallyactive ( =0812 nM)5-HT2A Ki
and (dopamine D2enspreceptor Ki
=0142 nM) antagonist
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 100 mg
Blonanserin D5 (AD-5423 D5) Cat No HY-13575S1
Blonanserin D5 (AD-5423 D5) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin D8 (AD-5423 D8) Cat No HY-13575S
Blonanserin D8 (AD-5423 D8) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brexpiprazole (OPC-34712) Cat No HY-15780
Brexpiprazole (OPC-34712) an atypicalantipsychotic drug is a partial agonist of human
and with s of 0125-HT1A dopamine receptor Ki
nM and 03 nM respectively Brexpiprazole is alsoa receptor antagonist with a of 0475-HT2A Ki
nM
Purity 9940Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
Brexpiprazole S-oxide (DM-3411) Cat No HY-133152
Brexpiprazole S-oxide (DM-3411) is a mainmetabolite of Brexpiprazole and is metabolized bycytochrome P450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 5 mg
Brexpiprazole S-oxide D8 (DM-3411 D8) Cat No HY-133152S
Brexpiprazole S-oxide D8 (DM-3411 D8) is adeuterium labeled Brexpiprazole S-oxideBrexpiprazole S-oxide is a main metabolite ofBrexpiprazole and is metabolized by cytochromeP450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brilaroxazine (RP5063) Cat No HY-109112
Brilaroxazine (RP5603) is a potent and orallyactive multimodal dopamine (DA)serotonin
modulator(5-HT)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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BRL 54443Cat No HY-13221
BRL 54443 is a potent receptor agonist5-HT1E1F
( values are 11 nM and 07 nM respectively)Ki
displays gt 30-fold selectivity over other 5-HTand dopamine receptors
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
BRL-15572 dihydrochlorideCat No HY-13200
BRL-15572 dihydrochloride is a selectiveantagonist of displays high affinity forh5-HT1D
BRL-15572 dihydrochlorideh5-HT1D receptorscould be useful pharmacological agents tocharacterise mediated responses5-HT1D receptor
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Bromperidol (R-11333) Cat No HY-B0901
Bromperidol is a butyrophenone derivative is apotent and long-acting neuroleptic used as anantipsychotic in the treatment of schizophrenia
Purity 9802Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Buspirone hydrochlorideCat No HY-B1115
Buspirone hydrochloride is an anxiolyticpsychotropic drug is used to treat generalizedanxiety disorder (GAD)
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Cariprazine (RGH-188) Cat No HY-14763
Cariprazine is a novel antipsychotic drugcandidate that exhibits high affinity for the D3
( =0085 nM) and ( =049 nM) receptors andKi D2 Ki
moderate affinity for the receptor5-HT1A
( =26 nM)Ki
Purity 9935Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg
Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A
Cariprazine hydrochloride is a novel antipsychoticdrug candidate that exhibits high affinity for the
( =0085 nM) and ( =049 nM)D3 Ki D2 Ki
receptors and moderate affinity for the 5-HT1A
receptor ( =26 nM)Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 50 mg
CART(62-76)(humanrat)Cat No HY-P1303
CART(62-76)(humanrat) is a neuropeptide (62-76residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
CART(62-76)(humanrat) TFACat No HY-P1303A
CART(62-76)(humanrat) TFA is a neuropeptide(62-76 residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Chlorpromazine D6 hydrochlorideCat No HY-B0407AS
Chlorpromazine D6 hydrochloride is the deuteriumlabeled Chlorpromazine Chlorpromazine is aninhibitor of dopamine receptor 5-HT receptorpotassium channel sodium channel
Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
Chlorpromazine hydrochlorideCat No HY-B0407A
Chlorpromazine hydrochloride is an antagonist ofthe dopamine D2 5HT2A potassium channeland Chlorpromazine binds with D2sodium channeland 5HT2A with s of 363 nM and 83 nMKi
respectively
Purity 9990Clinical Data LaunchedSize 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Cinanserin hydrochloride (SQ 10643) Cat No HY-100943
Cinanserin hydrochloride (SQ 10643) is a potentselective and highly affinity 5-HT receptor2
antagonist with a of 41 nM CinanserinKi
hydrochloride has a much higher binding affinityfor the than for the 5-HT receptor (5-HT2 1 Ki
of 3500 nM)
Purity 9974Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
cis-(Z)-Flupentixol dihydrochloride (cis-(Z)-Flupenthixol dihydrochloride) Cat No HY-15856
cis-(Z)-Flupentixol dihydrochloride is a potentand selective antagonist withDA D1D2 receptor
values of 038 nM and 7 nM for D2 receptor andKi
respectively5-HT2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
cis-Urocanic acid ((Z)-Urocanic acid cis-UCA) Cat No HY-113008A
cis-Urocanic acid is a agonist5-HT2A receptorcis-Urocanic acid binds to with5-HT receptorrelatively high affinity ( =46 nM)Kd
cis-Urocanic acid is an immune modulator thatinduces immunosuppression by binding to the 5-HT2Areceptor
Purity 9992Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg
Cisapride (R 51619 (plusmn)-Cisaprid) Cat No HY-14149
Cisapride(R 51619) is a nonselective 5-HT4receptor agonist it is also a potent hERGpotassium channel inhibitor
Purity 9972Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073
Clocapramine is an antagonist of the D2
5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A
Clocapramine hydrochloride hydrate is anantagonist of the and D2 5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
CP-809101 hydrochlorideCat No HY-15543A
CP-809101 hydrochloride is a potent and selective5-HT2C receptor agonist with pEC50 of996719681 for human 5-HT2C5-HT2B5-HT2Areceptors respectively
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
CyamemazineCat No HY-14264
Cyamemazine is a neuroleptic agent that containsthe phenothiazine chromophore Cyamemazine isoften used as an anxiolytic Cyamemazine is apotent ( of 12 nM) ( = 155-HT3 Ki 5-HT2A Ki
nM) and ( of 75 nM) receptors5-HT2C Ki
antagonist with antipsychotic activity
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Cyclobenzaprine hydrochloride (MK130 hydrochloride) Cat No HY-B0740
Cyclobenzaprine hydrochloride (MK130hydrochloride) is a skeletal muscle relaxant and acentral nervous system (CNS) depressant Target5-HT Receptor 2A Cyclobenzaprine hydrochloride isa skeletal muscle relaxant and a central nervoussystem (CNS) depressant
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Cyproheptadine hydrochlorideCat No HY-B0366A
Cyproheptadine hydrochloride is a 5-HT2A
antagonist with antidepressant andreceptorantiserotonergic effects Cyproheptadinehydrochloride has antiplatelet andthromboprotective activities
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg 1 g
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Cyproheptadine hydrochloride sesquihydrateCat No HY-B1165
Cyproheptadine hydrochloride sesquihydrate is anantihistamine and is an antagonist of serotoninand histamine2
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
Dehydroaripiprazole (OPC-14857 DM-14857) Cat No HY-100665
Dehydroaripiprazole (OPC-14857) is an activemetabolite of Aripiprazole Aripiprazole is anantipsychotic agent and is metabolized by CYP3A4and CYP2D6 forming mainly DehydroaripiprazoleDehydroaripiprazole has with antipsychoticactivity equivalent to Aripiprazole
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Deramciclane (EGIS-3886) Cat No HY-101630
Deramciclane has a high affinity for and5-HT2A
receptors it acts as an antagonist at5-HT2C
both receptor subtypes and has inverse agonistproperties at the 5-HT receptors without direct2C
stimulatory agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Dihydroergotamine mesylateCat No HY-B0670A
Dihydroergotamine mesylate is an ergot alkaloidused to treat migraines
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Dolasetron (MDL-73147) Cat No HY-B0750
Dolasetron(MDL-73147) is a serotonin 5-HT3receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
Dolasetron Mesylate (MDL-73147EF) Cat No HY-B0750A
Dolasetron Mesylate (MDL-73147EF) is a serotonin5-HT3 receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) Cat No HY-B0750B
Dolasetron Mesylate hydrate (MDL-73147EF hydrate)is a serotonin 5-HT3 receptor antagonist used totreat nausea and vomiting following chemotherapy
Purity gt990Clinical Data LaunchedSize 100 mg 200 mg
DonitriptanCat No HY-106157
Donitriptan is a potent high efficacy agonist ats with s of 94 and 935-HT receptor1B1D pKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eletriptan hydrobromide (Eletriptan HBr) Cat No HY-A0010
Eletriptan HBr is a selective 5-HT1B and 5-HT1Dreceptor agonist with Ki of 092 nM and 314 nMrespectively
Purity 9513Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Eltoprazine (DU 28853) Cat No HY-16687
Eltoprazine(DU28853) is a serenic orantiaggressive agent which as an agonist at the5-HT1A and 5-HT1B receptors and as an antagonistat the 5-HT2C receptor
Purity gt950Clinical Data Phase 2Size 1 mg 5 mg
wwwMedChemExpresscom 11
Eltoprazine hydrochloride (DU 28853 hydrochloride) Cat No HY-16687A
Eltoprazine hydrochloride (DU 28853 hydrochloride)is a serenic or antiaggressive agent which as anagonist at the 5-HT1A and 5-HT1B receptors and asan antagonist at the 5-HT2C receptor
Purity 9985Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
EMD 56551Cat No HY-19134
EMD 56551 is a potent and selective 5-HT1A agonist EMD 56551 exerts anxiolyticreceptor
activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eplivanserin (SR-46349) Cat No HY-10792
Eplivanserin is a potent selective and orallyavailable antagonist with an5-HT receptor2
of 58 nM in rat cortical membrane and aIC50
of 114 nMKd
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Eplivanserin (mixture) (SR-46349 (mixture)) Cat No HY-10792A
Eplivanserin mixture (SR-46349 mixture) is aselective inhibitor and aserotonin reuptake
antagonist extracted from5-HT receptor2A
patent WO 2005002578 A1
Purity 9995Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Eptapirone (F 11440) Cat No HY-19946
Eptapirone (F11440) is a potent selective highefficacy 5-HT1A receptor agonist with markedanxiolytic and antidepressant potential
Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
F-15599 (NLX-101) Cat No HY-19863
F-15599 is a highly selective G-protein biased agonist with of 34 nM5-HT1A receptor Ki
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Fabesetron (FK1052 free base) Cat No HY-105201
Fabesetron (FK1052) is an orally active 5-HT3
antagonist with receptor 5-HT receptor4
antagonistic activity Fabesetron (FK1052) can beused in the study for both acute and delayedemesis induced by cancer chemotherapy
Purity 9572Clinical Data No Development ReportedSize 1 mg 5 mg
Facinicline hydrochloride (RG3487 hydrochloride) Cat No HY-108057A
Facinicline hydrochloride (RG3487 hydrochloride)is an orally active partialnicotinic α7 receptoragonist with a of 6 nM for α7 human nAChRKi
Facinicline hydrochloride (RG3487 hydrochloride)improves cognition and sensorimotor gating inrodents
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Fananserin (RP 62203) Cat No HY-103104
Fananserin (RP 62203) is an orally bioavailablepotent and selective 5-hydroxytryptamine2
receptor antagonist with a of 037(5-HT )2 Ki
nM for the rat 5-HT receptor2A
Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
FlesinoxanCat No HY-121653
Flesinoxan is a hypotensive agent and a potenthigh affinity and selective5-hydroxytryptamine1A (5-HT1A) receptoragonist with an value of 24 nM FlesinoxanEC50
also has effective anxiolyticantidepressanteffects
Purity 9907Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 1 g
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
18 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
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Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
(plusmn)-Fabesetron hydrochloride ((plusmn)-FK1052) Cat No HY-101638
(plusmn)-Fabesetron hydrochloride ((plusmn)-FK1052) is theracemate of Fabesetron hydrochloride which is apotent and receptor dual antagonist5-HT3 5-HT4
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
2-O-MethylisoliquiritigeninCat No HY-N1745
2-O-Methylisoliquiritigenin isolated from the species up-regulates andArachis 5-HT NE DA
pathways but does not put a veryGABAsignificant effect on ne NE pathway
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine
2-Methylserotonin 2-Me-5-HT) Cat No HY-19358
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is apotent and selective agonist5-HT receptor3
2-Methyl-5-HT is shown to displayanti-depressive-like effects
Purity 9809Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine
hydrochloride 2-Methylserotonin hydrochloride hellip) Cat No HY-19358A
2-Methyl-5-HT hydrochloride(2-Methyl-5-hydroxytryptamine hydrochloride) is apotent and selective agonist5-HT receptor3
2-Methyl-5-HT hydrochloride is shown to displayanti-depressive-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate
2-Methylserotonin maleate 2-Me-HT maleate) Cat No HY-19358B
2-Methyl-5-HT maleate(2-Methyl-5-hydroxytryptamine maleate) is a potentand selective agonist5-HT receptor3
2-Methyl-5-HT maleate is shown to displayanti-depressive-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
3-Hydroxy agomelatineCat No HY-133111
3-Hydroxy agomelatine is a metabolite ofAgomelatine 3-Hydroxy agomelatine is a 5-HT2C
antagonist with an of 32 μM and areceptor IC50
of 18 μMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg
5-Carboxamidotryptamine maleate (5-CT maleate) Cat No HY-100942
5-Carboxamidotryptamine maleate (5-CT maleate) isa potent and5-HT1A 5-HT1B 5-HT1D 5-HT5
agonist5-HT receptors7
Purity gt98Clinical Data No Development ReportedSize 5 mg
5-HT1A modulator 1Cat No HY-100290
5-HT1A modulator 1 displays very high affinitiesfor the and 5HT1A adrenergic α1 dopamine
with s of 2 plusmn03 nM 10 plusmn 3 nMD receptor2 IC50
and 40 plusmn9 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT1A modulator 2 hydrochlorideCat No HY-136621
5-HT1A modulator 2 hydrochloride a derivative of8-OH-DPAT (HY-112061) is a modulator of 5-HT1A
with a of 53 nM for 5-HT bindingKi 1A
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
5-HT2 antagonist 1Cat No HY-U00365
5-HT2 antagonist 1 is a potent antagonist of with weak 5-HT2 receptor α1 adrenoceptor
blocking activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 3
5-HT2A antagonist 1Cat No HY-U00286
5-HT2A antagonist 1 is a antagonist5-HT2Aextracted from patent US5728835A and JP 10077275-HT2A antagonist 1 may be useful in treatment ofgastrointestinal disorders circulatory disorders
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3 antagonist 1Cat No HY-U00368
5-HT3 antagonist 1 is a potent and selectiveantagonist of serotonin 3 (5-HT3) receptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3 antagonist 2Cat No HY-U00408
5-HT3 antagonist 2 is a receptor5-HT3antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3 antagonist 3Cat No HY-U00322
5-HT3 antagonist 3 (Compound 15b) is ahigh-affinity antagonist 5-HT35-HT3 receptorantagonist 3 binds to 5-HT3 receptors in rat braincortical membranes with of 025 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3-In-1Cat No HY-U00413
5-HT3-In-1 is extracted from patent EP0748807A1compound example 8 It shows inhibition5-HT3activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT67 antagonist 1Cat No HY-101622
5-HT67 antagonist 1 is a multifunctional ligandthat antagonizes and receptors5-HT672A D2without interacting with M1 receptors and hERGchannels
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT7 agonist 1Cat No HY-109527
5-HT7 agonist 1 is a selective 5-HT7 receptoragonist with an of 22293 nM can be usedIC50
for the 5-HT7 receptor related disease such asCNS disorders
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine) Cat No HY-133112
7-Desmethyl-3-hydroxyagomelatine(3-Hydroxy-7-desmethyl agomelatine) a metaboliteof Agomelatine has less activity thanAgomelatine Agomelatine is a melatonergic( and ) agonist and MT1 MT2 serotonergic( ) antagonist5HT2C
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
7-Desmethyl-agomelatineCat No HY-133113
7-Desmethyl-agomelatine is a metabolite ofAgomelatine Agomelatineis a potent agonist atmelatonin receptors (MT1 and MT2) and also is anantagonist of 5-HT2C
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) Cat No HY-15688
8-Hydroxy-DPAT hydrobromide (8-OH-DPAThydrobromide) is a potent and selective 5-HT1A
agonist with a of 819 8-Hydroxy-DPATpIC50
hydrobromide has selectivity of almost 1000 foldfor a subtype of the 5-HT binding site1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
4 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
8-OH-DPAT (8-Hydroxy-DPAT) Cat No HY-112061
8-OH-DPAT is a potent and selective agonist5-HTwith a of 819 for 5-HT1A and a of 466 nMpIC50 Ki
for 5-HT7 8-OH-DPAT weakly binds to 5-HT1B (pIC 50
542) 5-HT (pIC lt5)50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
AbaperidoneCat No HY-101619
Abaperidone is a potent antagonist of and 5-HT receptor2A dopamine D receptor2
with s of 62 and 17 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Adoprazine (SLV313) Cat No HY-14782
Adoprazine a potential atypical antipsychoticbearing potent D2 receptor antagonist and 5-HT1Areceptor agonist properties
Purity 9810Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Agomelatine (S-20098) Cat No HY-17038
Agomelatine (S-20098) is a specific agonist of and receptors with s of 01 006MT1 MT2 Ki
012 and 027 nM for CHO-hMT1 HEK-hMT1CHO-hMT2 and HEK-hMT2 respectively
Purity 9877Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Agomelatine (L(+)-Tartaric acid) (S-20098 L(+)-Tartaric acid) Cat No HY-17038B
Agomelatine L(+)-Tartaric acid (S-20098L(+)-Tartaric acid) is a specific agonist of
and receptors with s of 01 006MT1 MT2 Ki
012 and 027 nM for CHO-hMT1 HEK-hMT1CHO-hMT2 and HEK-hMT2 respectively
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Agomelatine hydrochloride (S-20098 hydrochloride) Cat No HY-17038A
Agomelatine hydrochloride (S-20098 hydrochloride)is a specific agonist of and MT1 MT2receptors with s of 01 006 012 and 027 nMKi
for CHO-hMT1 HEK-hMT1 CHO-hMT2 and HEK-hMT2respectively
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
AlmotriptanCat No HY-B0383A
Almotriptan is a 5-HT1B1D-receptor agonist usedto treat migraine
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Almotriptan malate (PNU180638) Cat No HY-B0383
Almotriptan Malate is a 5-HT1B1D-receptor agonistused to treat migraine
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Alniditan (Alnitidan) Cat No HY-101698
Alniditan is a potent 5-HT receptors1B1D
agonist with of 17 and 13 nM in HEK293IC50
cells and value of 896 and 940 forpKi
5-HT receptors respectively1B1D
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Alosetron (GR 68755 GR 68755X) Cat No HY-70050A
Alosetron (GR 68755) is a potent and highlyselective serotonin antagonist5-HT3 receptorAlosetron is used for the research of irritablebowel syndrome (IBS)
Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 25 mg
wwwMedChemExpresscom 5
Alosetron ((Z)-2-butenedioate) (GR 68755
((Z)-2-butenedioate) GR 68755X ((Z)-2-butenedioate)) Cat No HY-70050B
Alosetron (GR 68755) (Z)-2-butenedioate is apotent and highly selective serotonin 5-HT3
antagonist Alosetron (Z)-2-butenedioatereceptoris used for the research of irritable bowelsyndrome (IBS)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Alosetron (Hydrochloride(1X)) (GR 68755
(Hydrochloride(1X)) GR 68755X (Hydrochloride(1X))) Cat No HY-70050
Alosetron (GR 68755) Hydrochloride(1X) is apotent and highly selective serotonin 5-HT3
antagonist Alosetron Hydrochloride(1X)receptoris used for the research of irritable bowelsyndrome (IBS)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Alosetron Hydrochloride (GR 68755C GR 68755 Hydrochloride
GR 68755X Hydrochloride) Cat No HY-70050C
Alosetron Hydrochloride (GR 68755C) is a potentand highly selective serotonin 5-HT3 receptorantagonist Alosetron Hydrochloride is used forthe research of irritable bowel syndrome (IBS)
Purity 9979Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Alprenolol ((RS)-Alprenolol dl-Alprenolol) Cat No HY-B1517
Alprenolol is a non-selective beta blocker as wellas 5-HT1A receptor antagonist The reference foradministration is 10 mgkg
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg
Alprenolol hydrochloride ((RS)-Alprenolol hydrochloride
dl-Alprenolol hydrochloride) Cat No HY-B1517A
Alprenolol (hydrochloride) is a non-selective betablocker as well as 5-HT1A receptor antagonist Thereference for administration is 10 mgkg
Purity 9958Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Alverine citrate (NSC 35459) Cat No HY-B0500
Alverine citrate is a receptor5-HT1A
antagonist with an of 101 nMIC50
Purity 9943Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Amitriptyline hydrochlorideCat No HY-B0527A
Amitriptyline hydrochloride is an inhibitor of andserotonin reuptake transporter (SERT)
with snoradrenaline reuptake transporter (NET) Ki
of 345 nM and 133 nM for human SERT and NETrespectively
Purity 9956Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ansofaxine hydrochloride (LY03005 LPM570065) Cat No HY-U00096
Ansofaxine hydrochloride (LY03005 LPM570065) is atriple reuptake inhibitor inhibits serotonin
and reuptake with dopamine norepinephrine IC50
values of 723 491 and 763 nM respectively
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 20 mg 50 mg 100 mg
AP521Cat No HY-100166
AP521 is an agonist of human 5-HT receptor1A
with an of 94 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AR-A 2 (AR-A 000002) Cat No HY-107018
AR-A 2 is a selective 5-HT receptor1B
antagonist with high affinity to guinea pigcortex and recombinant guinea pig5HT1B1D
( =024 and 047 nM) and with5-HT receptors1B Ki
10-fold lower affinity to guinea pig 5-HT1D
( 5 nM) and shows an ofhellipreceptor Ki EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Aripiprazole (OPC-14597) Cat No HY-14546
Aripiprazole (OPC-14597) is a human 5-HT1Areceptor partial agonist with a Ki of 42 nM
Purity 9998Clinical Data LaunchedSize 100 mg 200 mg 500 mg 1 g
ArotinololCat No HY-122537A
Arotinolol is a nonselective αβ-adrenergic blocker and a vasodilating β-blockerreceptor
Arotinolol also shows potency for inhibiting thebinding of the radioligand I-ICYP to125
-serotonergic receptor sites5HT1B
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
AS19Cat No HY-103142
AS19 is a potent selective 5-HT receptor7
agonist with an value of 083 nM and a ofIC50 Ki
06 nM AS19 is selective for over5-HT7
5-HT 5-HT 5-HT and 5-HT receptors1A 1B 1D 5A
( s = 897 nM 490 nM 66 nM and 985 nMKi
respectively)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Asenapine (Org 5222) Cat No HY-10121
Asenapine is an antagonist of serotonin receptors(5-HT 5-HT 5-HT 5-HT 5-HT )2A 2B 2C 6 7
(α α α α )adrenoceptors 1 2A 2B 2C
(D D D ) anddopamine receptors 2 3 4
(H H ) with shistamine receptors 1 2 pKi
of 84-105 89-95 89-94 andhellip
Purity 9881Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine hydrochlorideCat No HY-16567
Asenapine hydrochloride an antipsychotic is a (1A 1B 2A 2B 2C 5A 6 7) and 5-HT
receptor antagonist withDopamine (D D D )2 3 4
values of 003-40 nM for 5-HT and 13 042Ki
11 nM for Dopamine receptor respectively
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine maleate (Org 5222 maleate) Cat No HY-11100
Asenapine maleate is a (1A 1B 2A 2B 2C5-HT5A 6 7) and antagonist with values ofD2 Ki
003-40 nM 13nM respectively and anantipsychotic
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg
AsimilobineCat No HY-N7512
Asimilobine is an aporphine isoquinoline alkaloidisolated from plant species of Magnolia obobataThun Asimilobine is a biosynthesisdopamineinhibitor and a antagonistserotonergic receptorAsimilobine shows an andantimalarialanti-cancer activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AVN-492Cat No HY-101924
AVN-492 is a very specific and highly-selectiveantagonist with picomolar affinity to 5-HT6R( =91 pM)Ki
Purity 9949Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Azasetron hydrochloride (Y-25130 hydrochloride) Cat No HY-B0068
Azasetron (Y-25130) hydrochloride a benzamidederivative is a potent and selective 5-HT3receptor antagonist Azasetron is used in thestudy for Chemotherapy-induced nausea and vomiting(CINV)
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Befiradol (NLX-112 F13640) Cat No HY-14785
Befiradol (NLX-112) is a selective 5-HT1Areceptor agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 7
Befiradol hydrochloride (NLX-112 hydrochloride F 13640 hydrochloride) Cat No HY-14785A
Befiradol hydrochloride (NLX-112 hydrochloride) isa selective receptor agonist5-HT1A
Purity 9922Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Bemesetron (MDL 72222) Cat No HY-B1541
Bemesetron (MDL 72222) is a selective 5-HT3
antagonist with an of 033 nMreceptor IC50
Neuroprotective effect
Purity gt990Clinical Data No Development ReportedSize 10 mg
BGC20-761Cat No HY-21995
BGC20-761 is a selecvtive and 5-HT6 dopamine antagonist (human receptor valuesreceptor Ki
5-HT6 (20 nM) 5-HT2A (69 nM) D2 (140 nM)BGC20-761 can enhance long-term memory BGC20-761has potential utility as an antipsychotic agent
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin (AD-5423) Cat No HY-13575
Blonanserin (AD-5423) is a potent and orallyactive ( =0812 nM)5-HT2A Ki
and (dopamine D2enspreceptor Ki
=0142 nM) antagonist
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 100 mg
Blonanserin D5 (AD-5423 D5) Cat No HY-13575S1
Blonanserin D5 (AD-5423 D5) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin D8 (AD-5423 D8) Cat No HY-13575S
Blonanserin D8 (AD-5423 D8) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brexpiprazole (OPC-34712) Cat No HY-15780
Brexpiprazole (OPC-34712) an atypicalantipsychotic drug is a partial agonist of human
and with s of 0125-HT1A dopamine receptor Ki
nM and 03 nM respectively Brexpiprazole is alsoa receptor antagonist with a of 0475-HT2A Ki
nM
Purity 9940Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
Brexpiprazole S-oxide (DM-3411) Cat No HY-133152
Brexpiprazole S-oxide (DM-3411) is a mainmetabolite of Brexpiprazole and is metabolized bycytochrome P450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 5 mg
Brexpiprazole S-oxide D8 (DM-3411 D8) Cat No HY-133152S
Brexpiprazole S-oxide D8 (DM-3411 D8) is adeuterium labeled Brexpiprazole S-oxideBrexpiprazole S-oxide is a main metabolite ofBrexpiprazole and is metabolized by cytochromeP450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brilaroxazine (RP5063) Cat No HY-109112
Brilaroxazine (RP5603) is a potent and orallyactive multimodal dopamine (DA)serotonin
modulator(5-HT)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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BRL 54443Cat No HY-13221
BRL 54443 is a potent receptor agonist5-HT1E1F
( values are 11 nM and 07 nM respectively)Ki
displays gt 30-fold selectivity over other 5-HTand dopamine receptors
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
BRL-15572 dihydrochlorideCat No HY-13200
BRL-15572 dihydrochloride is a selectiveantagonist of displays high affinity forh5-HT1D
BRL-15572 dihydrochlorideh5-HT1D receptorscould be useful pharmacological agents tocharacterise mediated responses5-HT1D receptor
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Bromperidol (R-11333) Cat No HY-B0901
Bromperidol is a butyrophenone derivative is apotent and long-acting neuroleptic used as anantipsychotic in the treatment of schizophrenia
Purity 9802Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Buspirone hydrochlorideCat No HY-B1115
Buspirone hydrochloride is an anxiolyticpsychotropic drug is used to treat generalizedanxiety disorder (GAD)
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Cariprazine (RGH-188) Cat No HY-14763
Cariprazine is a novel antipsychotic drugcandidate that exhibits high affinity for the D3
( =0085 nM) and ( =049 nM) receptors andKi D2 Ki
moderate affinity for the receptor5-HT1A
( =26 nM)Ki
Purity 9935Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg
Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A
Cariprazine hydrochloride is a novel antipsychoticdrug candidate that exhibits high affinity for the
( =0085 nM) and ( =049 nM)D3 Ki D2 Ki
receptors and moderate affinity for the 5-HT1A
receptor ( =26 nM)Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 50 mg
CART(62-76)(humanrat)Cat No HY-P1303
CART(62-76)(humanrat) is a neuropeptide (62-76residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
CART(62-76)(humanrat) TFACat No HY-P1303A
CART(62-76)(humanrat) TFA is a neuropeptide(62-76 residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Chlorpromazine D6 hydrochlorideCat No HY-B0407AS
Chlorpromazine D6 hydrochloride is the deuteriumlabeled Chlorpromazine Chlorpromazine is aninhibitor of dopamine receptor 5-HT receptorpotassium channel sodium channel
Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
Chlorpromazine hydrochlorideCat No HY-B0407A
Chlorpromazine hydrochloride is an antagonist ofthe dopamine D2 5HT2A potassium channeland Chlorpromazine binds with D2sodium channeland 5HT2A with s of 363 nM and 83 nMKi
respectively
Purity 9990Clinical Data LaunchedSize 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Cinanserin hydrochloride (SQ 10643) Cat No HY-100943
Cinanserin hydrochloride (SQ 10643) is a potentselective and highly affinity 5-HT receptor2
antagonist with a of 41 nM CinanserinKi
hydrochloride has a much higher binding affinityfor the than for the 5-HT receptor (5-HT2 1 Ki
of 3500 nM)
Purity 9974Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
cis-(Z)-Flupentixol dihydrochloride (cis-(Z)-Flupenthixol dihydrochloride) Cat No HY-15856
cis-(Z)-Flupentixol dihydrochloride is a potentand selective antagonist withDA D1D2 receptor
values of 038 nM and 7 nM for D2 receptor andKi
respectively5-HT2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
cis-Urocanic acid ((Z)-Urocanic acid cis-UCA) Cat No HY-113008A
cis-Urocanic acid is a agonist5-HT2A receptorcis-Urocanic acid binds to with5-HT receptorrelatively high affinity ( =46 nM)Kd
cis-Urocanic acid is an immune modulator thatinduces immunosuppression by binding to the 5-HT2Areceptor
Purity 9992Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg
Cisapride (R 51619 (plusmn)-Cisaprid) Cat No HY-14149
Cisapride(R 51619) is a nonselective 5-HT4receptor agonist it is also a potent hERGpotassium channel inhibitor
Purity 9972Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073
Clocapramine is an antagonist of the D2
5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A
Clocapramine hydrochloride hydrate is anantagonist of the and D2 5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
CP-809101 hydrochlorideCat No HY-15543A
CP-809101 hydrochloride is a potent and selective5-HT2C receptor agonist with pEC50 of996719681 for human 5-HT2C5-HT2B5-HT2Areceptors respectively
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
CyamemazineCat No HY-14264
Cyamemazine is a neuroleptic agent that containsthe phenothiazine chromophore Cyamemazine isoften used as an anxiolytic Cyamemazine is apotent ( of 12 nM) ( = 155-HT3 Ki 5-HT2A Ki
nM) and ( of 75 nM) receptors5-HT2C Ki
antagonist with antipsychotic activity
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Cyclobenzaprine hydrochloride (MK130 hydrochloride) Cat No HY-B0740
Cyclobenzaprine hydrochloride (MK130hydrochloride) is a skeletal muscle relaxant and acentral nervous system (CNS) depressant Target5-HT Receptor 2A Cyclobenzaprine hydrochloride isa skeletal muscle relaxant and a central nervoussystem (CNS) depressant
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Cyproheptadine hydrochlorideCat No HY-B0366A
Cyproheptadine hydrochloride is a 5-HT2A
antagonist with antidepressant andreceptorantiserotonergic effects Cyproheptadinehydrochloride has antiplatelet andthromboprotective activities
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg 1 g
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Cyproheptadine hydrochloride sesquihydrateCat No HY-B1165
Cyproheptadine hydrochloride sesquihydrate is anantihistamine and is an antagonist of serotoninand histamine2
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
Dehydroaripiprazole (OPC-14857 DM-14857) Cat No HY-100665
Dehydroaripiprazole (OPC-14857) is an activemetabolite of Aripiprazole Aripiprazole is anantipsychotic agent and is metabolized by CYP3A4and CYP2D6 forming mainly DehydroaripiprazoleDehydroaripiprazole has with antipsychoticactivity equivalent to Aripiprazole
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Deramciclane (EGIS-3886) Cat No HY-101630
Deramciclane has a high affinity for and5-HT2A
receptors it acts as an antagonist at5-HT2C
both receptor subtypes and has inverse agonistproperties at the 5-HT receptors without direct2C
stimulatory agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Dihydroergotamine mesylateCat No HY-B0670A
Dihydroergotamine mesylate is an ergot alkaloidused to treat migraines
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Dolasetron (MDL-73147) Cat No HY-B0750
Dolasetron(MDL-73147) is a serotonin 5-HT3receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
Dolasetron Mesylate (MDL-73147EF) Cat No HY-B0750A
Dolasetron Mesylate (MDL-73147EF) is a serotonin5-HT3 receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) Cat No HY-B0750B
Dolasetron Mesylate hydrate (MDL-73147EF hydrate)is a serotonin 5-HT3 receptor antagonist used totreat nausea and vomiting following chemotherapy
Purity gt990Clinical Data LaunchedSize 100 mg 200 mg
DonitriptanCat No HY-106157
Donitriptan is a potent high efficacy agonist ats with s of 94 and 935-HT receptor1B1D pKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eletriptan hydrobromide (Eletriptan HBr) Cat No HY-A0010
Eletriptan HBr is a selective 5-HT1B and 5-HT1Dreceptor agonist with Ki of 092 nM and 314 nMrespectively
Purity 9513Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Eltoprazine (DU 28853) Cat No HY-16687
Eltoprazine(DU28853) is a serenic orantiaggressive agent which as an agonist at the5-HT1A and 5-HT1B receptors and as an antagonistat the 5-HT2C receptor
Purity gt950Clinical Data Phase 2Size 1 mg 5 mg
wwwMedChemExpresscom 11
Eltoprazine hydrochloride (DU 28853 hydrochloride) Cat No HY-16687A
Eltoprazine hydrochloride (DU 28853 hydrochloride)is a serenic or antiaggressive agent which as anagonist at the 5-HT1A and 5-HT1B receptors and asan antagonist at the 5-HT2C receptor
Purity 9985Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
EMD 56551Cat No HY-19134
EMD 56551 is a potent and selective 5-HT1A agonist EMD 56551 exerts anxiolyticreceptor
activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eplivanserin (SR-46349) Cat No HY-10792
Eplivanserin is a potent selective and orallyavailable antagonist with an5-HT receptor2
of 58 nM in rat cortical membrane and aIC50
of 114 nMKd
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Eplivanserin (mixture) (SR-46349 (mixture)) Cat No HY-10792A
Eplivanserin mixture (SR-46349 mixture) is aselective inhibitor and aserotonin reuptake
antagonist extracted from5-HT receptor2A
patent WO 2005002578 A1
Purity 9995Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Eptapirone (F 11440) Cat No HY-19946
Eptapirone (F11440) is a potent selective highefficacy 5-HT1A receptor agonist with markedanxiolytic and antidepressant potential
Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
F-15599 (NLX-101) Cat No HY-19863
F-15599 is a highly selective G-protein biased agonist with of 34 nM5-HT1A receptor Ki
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Fabesetron (FK1052 free base) Cat No HY-105201
Fabesetron (FK1052) is an orally active 5-HT3
antagonist with receptor 5-HT receptor4
antagonistic activity Fabesetron (FK1052) can beused in the study for both acute and delayedemesis induced by cancer chemotherapy
Purity 9572Clinical Data No Development ReportedSize 1 mg 5 mg
Facinicline hydrochloride (RG3487 hydrochloride) Cat No HY-108057A
Facinicline hydrochloride (RG3487 hydrochloride)is an orally active partialnicotinic α7 receptoragonist with a of 6 nM for α7 human nAChRKi
Facinicline hydrochloride (RG3487 hydrochloride)improves cognition and sensorimotor gating inrodents
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Fananserin (RP 62203) Cat No HY-103104
Fananserin (RP 62203) is an orally bioavailablepotent and selective 5-hydroxytryptamine2
receptor antagonist with a of 037(5-HT )2 Ki
nM for the rat 5-HT receptor2A
Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
FlesinoxanCat No HY-121653
Flesinoxan is a hypotensive agent and a potenthigh affinity and selective5-hydroxytryptamine1A (5-HT1A) receptoragonist with an value of 24 nM FlesinoxanEC50
also has effective anxiolyticantidepressanteffects
Purity 9907Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 1 g
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Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
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LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
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Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
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Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
5-HT2A antagonist 1Cat No HY-U00286
5-HT2A antagonist 1 is a antagonist5-HT2Aextracted from patent US5728835A and JP 10077275-HT2A antagonist 1 may be useful in treatment ofgastrointestinal disorders circulatory disorders
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3 antagonist 1Cat No HY-U00368
5-HT3 antagonist 1 is a potent and selectiveantagonist of serotonin 3 (5-HT3) receptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3 antagonist 2Cat No HY-U00408
5-HT3 antagonist 2 is a receptor5-HT3antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3 antagonist 3Cat No HY-U00322
5-HT3 antagonist 3 (Compound 15b) is ahigh-affinity antagonist 5-HT35-HT3 receptorantagonist 3 binds to 5-HT3 receptors in rat braincortical membranes with of 025 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT3-In-1Cat No HY-U00413
5-HT3-In-1 is extracted from patent EP0748807A1compound example 8 It shows inhibition5-HT3activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT67 antagonist 1Cat No HY-101622
5-HT67 antagonist 1 is a multifunctional ligandthat antagonizes and receptors5-HT672A D2without interacting with M1 receptors and hERGchannels
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
5-HT7 agonist 1Cat No HY-109527
5-HT7 agonist 1 is a selective 5-HT7 receptoragonist with an of 22293 nM can be usedIC50
for the 5-HT7 receptor related disease such asCNS disorders
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine) Cat No HY-133112
7-Desmethyl-3-hydroxyagomelatine(3-Hydroxy-7-desmethyl agomelatine) a metaboliteof Agomelatine has less activity thanAgomelatine Agomelatine is a melatonergic( and ) agonist and MT1 MT2 serotonergic( ) antagonist5HT2C
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
7-Desmethyl-agomelatineCat No HY-133113
7-Desmethyl-agomelatine is a metabolite ofAgomelatine Agomelatineis a potent agonist atmelatonin receptors (MT1 and MT2) and also is anantagonist of 5-HT2C
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) Cat No HY-15688
8-Hydroxy-DPAT hydrobromide (8-OH-DPAThydrobromide) is a potent and selective 5-HT1A
agonist with a of 819 8-Hydroxy-DPATpIC50
hydrobromide has selectivity of almost 1000 foldfor a subtype of the 5-HT binding site1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
4 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
8-OH-DPAT (8-Hydroxy-DPAT) Cat No HY-112061
8-OH-DPAT is a potent and selective agonist5-HTwith a of 819 for 5-HT1A and a of 466 nMpIC50 Ki
for 5-HT7 8-OH-DPAT weakly binds to 5-HT1B (pIC 50
542) 5-HT (pIC lt5)50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
AbaperidoneCat No HY-101619
Abaperidone is a potent antagonist of and 5-HT receptor2A dopamine D receptor2
with s of 62 and 17 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Adoprazine (SLV313) Cat No HY-14782
Adoprazine a potential atypical antipsychoticbearing potent D2 receptor antagonist and 5-HT1Areceptor agonist properties
Purity 9810Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Agomelatine (S-20098) Cat No HY-17038
Agomelatine (S-20098) is a specific agonist of and receptors with s of 01 006MT1 MT2 Ki
012 and 027 nM for CHO-hMT1 HEK-hMT1CHO-hMT2 and HEK-hMT2 respectively
Purity 9877Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Agomelatine (L(+)-Tartaric acid) (S-20098 L(+)-Tartaric acid) Cat No HY-17038B
Agomelatine L(+)-Tartaric acid (S-20098L(+)-Tartaric acid) is a specific agonist of
and receptors with s of 01 006MT1 MT2 Ki
012 and 027 nM for CHO-hMT1 HEK-hMT1CHO-hMT2 and HEK-hMT2 respectively
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Agomelatine hydrochloride (S-20098 hydrochloride) Cat No HY-17038A
Agomelatine hydrochloride (S-20098 hydrochloride)is a specific agonist of and MT1 MT2receptors with s of 01 006 012 and 027 nMKi
for CHO-hMT1 HEK-hMT1 CHO-hMT2 and HEK-hMT2respectively
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
AlmotriptanCat No HY-B0383A
Almotriptan is a 5-HT1B1D-receptor agonist usedto treat migraine
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Almotriptan malate (PNU180638) Cat No HY-B0383
Almotriptan Malate is a 5-HT1B1D-receptor agonistused to treat migraine
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Alniditan (Alnitidan) Cat No HY-101698
Alniditan is a potent 5-HT receptors1B1D
agonist with of 17 and 13 nM in HEK293IC50
cells and value of 896 and 940 forpKi
5-HT receptors respectively1B1D
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Alosetron (GR 68755 GR 68755X) Cat No HY-70050A
Alosetron (GR 68755) is a potent and highlyselective serotonin antagonist5-HT3 receptorAlosetron is used for the research of irritablebowel syndrome (IBS)
Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 25 mg
wwwMedChemExpresscom 5
Alosetron ((Z)-2-butenedioate) (GR 68755
((Z)-2-butenedioate) GR 68755X ((Z)-2-butenedioate)) Cat No HY-70050B
Alosetron (GR 68755) (Z)-2-butenedioate is apotent and highly selective serotonin 5-HT3
antagonist Alosetron (Z)-2-butenedioatereceptoris used for the research of irritable bowelsyndrome (IBS)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Alosetron (Hydrochloride(1X)) (GR 68755
(Hydrochloride(1X)) GR 68755X (Hydrochloride(1X))) Cat No HY-70050
Alosetron (GR 68755) Hydrochloride(1X) is apotent and highly selective serotonin 5-HT3
antagonist Alosetron Hydrochloride(1X)receptoris used for the research of irritable bowelsyndrome (IBS)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Alosetron Hydrochloride (GR 68755C GR 68755 Hydrochloride
GR 68755X Hydrochloride) Cat No HY-70050C
Alosetron Hydrochloride (GR 68755C) is a potentand highly selective serotonin 5-HT3 receptorantagonist Alosetron Hydrochloride is used forthe research of irritable bowel syndrome (IBS)
Purity 9979Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Alprenolol ((RS)-Alprenolol dl-Alprenolol) Cat No HY-B1517
Alprenolol is a non-selective beta blocker as wellas 5-HT1A receptor antagonist The reference foradministration is 10 mgkg
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg
Alprenolol hydrochloride ((RS)-Alprenolol hydrochloride
dl-Alprenolol hydrochloride) Cat No HY-B1517A
Alprenolol (hydrochloride) is a non-selective betablocker as well as 5-HT1A receptor antagonist Thereference for administration is 10 mgkg
Purity 9958Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Alverine citrate (NSC 35459) Cat No HY-B0500
Alverine citrate is a receptor5-HT1A
antagonist with an of 101 nMIC50
Purity 9943Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Amitriptyline hydrochlorideCat No HY-B0527A
Amitriptyline hydrochloride is an inhibitor of andserotonin reuptake transporter (SERT)
with snoradrenaline reuptake transporter (NET) Ki
of 345 nM and 133 nM for human SERT and NETrespectively
Purity 9956Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ansofaxine hydrochloride (LY03005 LPM570065) Cat No HY-U00096
Ansofaxine hydrochloride (LY03005 LPM570065) is atriple reuptake inhibitor inhibits serotonin
and reuptake with dopamine norepinephrine IC50
values of 723 491 and 763 nM respectively
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 20 mg 50 mg 100 mg
AP521Cat No HY-100166
AP521 is an agonist of human 5-HT receptor1A
with an of 94 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AR-A 2 (AR-A 000002) Cat No HY-107018
AR-A 2 is a selective 5-HT receptor1B
antagonist with high affinity to guinea pigcortex and recombinant guinea pig5HT1B1D
( =024 and 047 nM) and with5-HT receptors1B Ki
10-fold lower affinity to guinea pig 5-HT1D
( 5 nM) and shows an ofhellipreceptor Ki EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Aripiprazole (OPC-14597) Cat No HY-14546
Aripiprazole (OPC-14597) is a human 5-HT1Areceptor partial agonist with a Ki of 42 nM
Purity 9998Clinical Data LaunchedSize 100 mg 200 mg 500 mg 1 g
ArotinololCat No HY-122537A
Arotinolol is a nonselective αβ-adrenergic blocker and a vasodilating β-blockerreceptor
Arotinolol also shows potency for inhibiting thebinding of the radioligand I-ICYP to125
-serotonergic receptor sites5HT1B
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
AS19Cat No HY-103142
AS19 is a potent selective 5-HT receptor7
agonist with an value of 083 nM and a ofIC50 Ki
06 nM AS19 is selective for over5-HT7
5-HT 5-HT 5-HT and 5-HT receptors1A 1B 1D 5A
( s = 897 nM 490 nM 66 nM and 985 nMKi
respectively)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Asenapine (Org 5222) Cat No HY-10121
Asenapine is an antagonist of serotonin receptors(5-HT 5-HT 5-HT 5-HT 5-HT )2A 2B 2C 6 7
(α α α α )adrenoceptors 1 2A 2B 2C
(D D D ) anddopamine receptors 2 3 4
(H H ) with shistamine receptors 1 2 pKi
of 84-105 89-95 89-94 andhellip
Purity 9881Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine hydrochlorideCat No HY-16567
Asenapine hydrochloride an antipsychotic is a (1A 1B 2A 2B 2C 5A 6 7) and 5-HT
receptor antagonist withDopamine (D D D )2 3 4
values of 003-40 nM for 5-HT and 13 042Ki
11 nM for Dopamine receptor respectively
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine maleate (Org 5222 maleate) Cat No HY-11100
Asenapine maleate is a (1A 1B 2A 2B 2C5-HT5A 6 7) and antagonist with values ofD2 Ki
003-40 nM 13nM respectively and anantipsychotic
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg
AsimilobineCat No HY-N7512
Asimilobine is an aporphine isoquinoline alkaloidisolated from plant species of Magnolia obobataThun Asimilobine is a biosynthesisdopamineinhibitor and a antagonistserotonergic receptorAsimilobine shows an andantimalarialanti-cancer activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AVN-492Cat No HY-101924
AVN-492 is a very specific and highly-selectiveantagonist with picomolar affinity to 5-HT6R( =91 pM)Ki
Purity 9949Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Azasetron hydrochloride (Y-25130 hydrochloride) Cat No HY-B0068
Azasetron (Y-25130) hydrochloride a benzamidederivative is a potent and selective 5-HT3receptor antagonist Azasetron is used in thestudy for Chemotherapy-induced nausea and vomiting(CINV)
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Befiradol (NLX-112 F13640) Cat No HY-14785
Befiradol (NLX-112) is a selective 5-HT1Areceptor agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 7
Befiradol hydrochloride (NLX-112 hydrochloride F 13640 hydrochloride) Cat No HY-14785A
Befiradol hydrochloride (NLX-112 hydrochloride) isa selective receptor agonist5-HT1A
Purity 9922Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Bemesetron (MDL 72222) Cat No HY-B1541
Bemesetron (MDL 72222) is a selective 5-HT3
antagonist with an of 033 nMreceptor IC50
Neuroprotective effect
Purity gt990Clinical Data No Development ReportedSize 10 mg
BGC20-761Cat No HY-21995
BGC20-761 is a selecvtive and 5-HT6 dopamine antagonist (human receptor valuesreceptor Ki
5-HT6 (20 nM) 5-HT2A (69 nM) D2 (140 nM)BGC20-761 can enhance long-term memory BGC20-761has potential utility as an antipsychotic agent
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin (AD-5423) Cat No HY-13575
Blonanserin (AD-5423) is a potent and orallyactive ( =0812 nM)5-HT2A Ki
and (dopamine D2enspreceptor Ki
=0142 nM) antagonist
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 100 mg
Blonanserin D5 (AD-5423 D5) Cat No HY-13575S1
Blonanserin D5 (AD-5423 D5) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin D8 (AD-5423 D8) Cat No HY-13575S
Blonanserin D8 (AD-5423 D8) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brexpiprazole (OPC-34712) Cat No HY-15780
Brexpiprazole (OPC-34712) an atypicalantipsychotic drug is a partial agonist of human
and with s of 0125-HT1A dopamine receptor Ki
nM and 03 nM respectively Brexpiprazole is alsoa receptor antagonist with a of 0475-HT2A Ki
nM
Purity 9940Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
Brexpiprazole S-oxide (DM-3411) Cat No HY-133152
Brexpiprazole S-oxide (DM-3411) is a mainmetabolite of Brexpiprazole and is metabolized bycytochrome P450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 5 mg
Brexpiprazole S-oxide D8 (DM-3411 D8) Cat No HY-133152S
Brexpiprazole S-oxide D8 (DM-3411 D8) is adeuterium labeled Brexpiprazole S-oxideBrexpiprazole S-oxide is a main metabolite ofBrexpiprazole and is metabolized by cytochromeP450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brilaroxazine (RP5063) Cat No HY-109112
Brilaroxazine (RP5603) is a potent and orallyactive multimodal dopamine (DA)serotonin
modulator(5-HT)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
BRL 54443Cat No HY-13221
BRL 54443 is a potent receptor agonist5-HT1E1F
( values are 11 nM and 07 nM respectively)Ki
displays gt 30-fold selectivity over other 5-HTand dopamine receptors
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
BRL-15572 dihydrochlorideCat No HY-13200
BRL-15572 dihydrochloride is a selectiveantagonist of displays high affinity forh5-HT1D
BRL-15572 dihydrochlorideh5-HT1D receptorscould be useful pharmacological agents tocharacterise mediated responses5-HT1D receptor
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Bromperidol (R-11333) Cat No HY-B0901
Bromperidol is a butyrophenone derivative is apotent and long-acting neuroleptic used as anantipsychotic in the treatment of schizophrenia
Purity 9802Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Buspirone hydrochlorideCat No HY-B1115
Buspirone hydrochloride is an anxiolyticpsychotropic drug is used to treat generalizedanxiety disorder (GAD)
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Cariprazine (RGH-188) Cat No HY-14763
Cariprazine is a novel antipsychotic drugcandidate that exhibits high affinity for the D3
( =0085 nM) and ( =049 nM) receptors andKi D2 Ki
moderate affinity for the receptor5-HT1A
( =26 nM)Ki
Purity 9935Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg
Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A
Cariprazine hydrochloride is a novel antipsychoticdrug candidate that exhibits high affinity for the
( =0085 nM) and ( =049 nM)D3 Ki D2 Ki
receptors and moderate affinity for the 5-HT1A
receptor ( =26 nM)Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 50 mg
CART(62-76)(humanrat)Cat No HY-P1303
CART(62-76)(humanrat) is a neuropeptide (62-76residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
CART(62-76)(humanrat) TFACat No HY-P1303A
CART(62-76)(humanrat) TFA is a neuropeptide(62-76 residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Chlorpromazine D6 hydrochlorideCat No HY-B0407AS
Chlorpromazine D6 hydrochloride is the deuteriumlabeled Chlorpromazine Chlorpromazine is aninhibitor of dopamine receptor 5-HT receptorpotassium channel sodium channel
Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
Chlorpromazine hydrochlorideCat No HY-B0407A
Chlorpromazine hydrochloride is an antagonist ofthe dopamine D2 5HT2A potassium channeland Chlorpromazine binds with D2sodium channeland 5HT2A with s of 363 nM and 83 nMKi
respectively
Purity 9990Clinical Data LaunchedSize 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Cinanserin hydrochloride (SQ 10643) Cat No HY-100943
Cinanserin hydrochloride (SQ 10643) is a potentselective and highly affinity 5-HT receptor2
antagonist with a of 41 nM CinanserinKi
hydrochloride has a much higher binding affinityfor the than for the 5-HT receptor (5-HT2 1 Ki
of 3500 nM)
Purity 9974Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
cis-(Z)-Flupentixol dihydrochloride (cis-(Z)-Flupenthixol dihydrochloride) Cat No HY-15856
cis-(Z)-Flupentixol dihydrochloride is a potentand selective antagonist withDA D1D2 receptor
values of 038 nM and 7 nM for D2 receptor andKi
respectively5-HT2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
cis-Urocanic acid ((Z)-Urocanic acid cis-UCA) Cat No HY-113008A
cis-Urocanic acid is a agonist5-HT2A receptorcis-Urocanic acid binds to with5-HT receptorrelatively high affinity ( =46 nM)Kd
cis-Urocanic acid is an immune modulator thatinduces immunosuppression by binding to the 5-HT2Areceptor
Purity 9992Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg
Cisapride (R 51619 (plusmn)-Cisaprid) Cat No HY-14149
Cisapride(R 51619) is a nonselective 5-HT4receptor agonist it is also a potent hERGpotassium channel inhibitor
Purity 9972Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073
Clocapramine is an antagonist of the D2
5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A
Clocapramine hydrochloride hydrate is anantagonist of the and D2 5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
CP-809101 hydrochlorideCat No HY-15543A
CP-809101 hydrochloride is a potent and selective5-HT2C receptor agonist with pEC50 of996719681 for human 5-HT2C5-HT2B5-HT2Areceptors respectively
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
CyamemazineCat No HY-14264
Cyamemazine is a neuroleptic agent that containsthe phenothiazine chromophore Cyamemazine isoften used as an anxiolytic Cyamemazine is apotent ( of 12 nM) ( = 155-HT3 Ki 5-HT2A Ki
nM) and ( of 75 nM) receptors5-HT2C Ki
antagonist with antipsychotic activity
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Cyclobenzaprine hydrochloride (MK130 hydrochloride) Cat No HY-B0740
Cyclobenzaprine hydrochloride (MK130hydrochloride) is a skeletal muscle relaxant and acentral nervous system (CNS) depressant Target5-HT Receptor 2A Cyclobenzaprine hydrochloride isa skeletal muscle relaxant and a central nervoussystem (CNS) depressant
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Cyproheptadine hydrochlorideCat No HY-B0366A
Cyproheptadine hydrochloride is a 5-HT2A
antagonist with antidepressant andreceptorantiserotonergic effects Cyproheptadinehydrochloride has antiplatelet andthromboprotective activities
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg 1 g
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Cyproheptadine hydrochloride sesquihydrateCat No HY-B1165
Cyproheptadine hydrochloride sesquihydrate is anantihistamine and is an antagonist of serotoninand histamine2
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
Dehydroaripiprazole (OPC-14857 DM-14857) Cat No HY-100665
Dehydroaripiprazole (OPC-14857) is an activemetabolite of Aripiprazole Aripiprazole is anantipsychotic agent and is metabolized by CYP3A4and CYP2D6 forming mainly DehydroaripiprazoleDehydroaripiprazole has with antipsychoticactivity equivalent to Aripiprazole
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Deramciclane (EGIS-3886) Cat No HY-101630
Deramciclane has a high affinity for and5-HT2A
receptors it acts as an antagonist at5-HT2C
both receptor subtypes and has inverse agonistproperties at the 5-HT receptors without direct2C
stimulatory agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Dihydroergotamine mesylateCat No HY-B0670A
Dihydroergotamine mesylate is an ergot alkaloidused to treat migraines
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Dolasetron (MDL-73147) Cat No HY-B0750
Dolasetron(MDL-73147) is a serotonin 5-HT3receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
Dolasetron Mesylate (MDL-73147EF) Cat No HY-B0750A
Dolasetron Mesylate (MDL-73147EF) is a serotonin5-HT3 receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) Cat No HY-B0750B
Dolasetron Mesylate hydrate (MDL-73147EF hydrate)is a serotonin 5-HT3 receptor antagonist used totreat nausea and vomiting following chemotherapy
Purity gt990Clinical Data LaunchedSize 100 mg 200 mg
DonitriptanCat No HY-106157
Donitriptan is a potent high efficacy agonist ats with s of 94 and 935-HT receptor1B1D pKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eletriptan hydrobromide (Eletriptan HBr) Cat No HY-A0010
Eletriptan HBr is a selective 5-HT1B and 5-HT1Dreceptor agonist with Ki of 092 nM and 314 nMrespectively
Purity 9513Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Eltoprazine (DU 28853) Cat No HY-16687
Eltoprazine(DU28853) is a serenic orantiaggressive agent which as an agonist at the5-HT1A and 5-HT1B receptors and as an antagonistat the 5-HT2C receptor
Purity gt950Clinical Data Phase 2Size 1 mg 5 mg
wwwMedChemExpresscom 11
Eltoprazine hydrochloride (DU 28853 hydrochloride) Cat No HY-16687A
Eltoprazine hydrochloride (DU 28853 hydrochloride)is a serenic or antiaggressive agent which as anagonist at the 5-HT1A and 5-HT1B receptors and asan antagonist at the 5-HT2C receptor
Purity 9985Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
EMD 56551Cat No HY-19134
EMD 56551 is a potent and selective 5-HT1A agonist EMD 56551 exerts anxiolyticreceptor
activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eplivanserin (SR-46349) Cat No HY-10792
Eplivanserin is a potent selective and orallyavailable antagonist with an5-HT receptor2
of 58 nM in rat cortical membrane and aIC50
of 114 nMKd
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Eplivanserin (mixture) (SR-46349 (mixture)) Cat No HY-10792A
Eplivanserin mixture (SR-46349 mixture) is aselective inhibitor and aserotonin reuptake
antagonist extracted from5-HT receptor2A
patent WO 2005002578 A1
Purity 9995Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Eptapirone (F 11440) Cat No HY-19946
Eptapirone (F11440) is a potent selective highefficacy 5-HT1A receptor agonist with markedanxiolytic and antidepressant potential
Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
F-15599 (NLX-101) Cat No HY-19863
F-15599 is a highly selective G-protein biased agonist with of 34 nM5-HT1A receptor Ki
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Fabesetron (FK1052 free base) Cat No HY-105201
Fabesetron (FK1052) is an orally active 5-HT3
antagonist with receptor 5-HT receptor4
antagonistic activity Fabesetron (FK1052) can beused in the study for both acute and delayedemesis induced by cancer chemotherapy
Purity 9572Clinical Data No Development ReportedSize 1 mg 5 mg
Facinicline hydrochloride (RG3487 hydrochloride) Cat No HY-108057A
Facinicline hydrochloride (RG3487 hydrochloride)is an orally active partialnicotinic α7 receptoragonist with a of 6 nM for α7 human nAChRKi
Facinicline hydrochloride (RG3487 hydrochloride)improves cognition and sensorimotor gating inrodents
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Fananserin (RP 62203) Cat No HY-103104
Fananserin (RP 62203) is an orally bioavailablepotent and selective 5-hydroxytryptamine2
receptor antagonist with a of 037(5-HT )2 Ki
nM for the rat 5-HT receptor2A
Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
FlesinoxanCat No HY-121653
Flesinoxan is a hypotensive agent and a potenthigh affinity and selective5-hydroxytryptamine1A (5-HT1A) receptoragonist with an value of 24 nM FlesinoxanEC50
also has effective anxiolyticantidepressanteffects
Purity 9907Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 1 g
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Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
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LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
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Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
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Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
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PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
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Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
8-OH-DPAT (8-Hydroxy-DPAT) Cat No HY-112061
8-OH-DPAT is a potent and selective agonist5-HTwith a of 819 for 5-HT1A and a of 466 nMpIC50 Ki
for 5-HT7 8-OH-DPAT weakly binds to 5-HT1B (pIC 50
542) 5-HT (pIC lt5)50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
AbaperidoneCat No HY-101619
Abaperidone is a potent antagonist of and 5-HT receptor2A dopamine D receptor2
with s of 62 and 17 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Adoprazine (SLV313) Cat No HY-14782
Adoprazine a potential atypical antipsychoticbearing potent D2 receptor antagonist and 5-HT1Areceptor agonist properties
Purity 9810Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Agomelatine (S-20098) Cat No HY-17038
Agomelatine (S-20098) is a specific agonist of and receptors with s of 01 006MT1 MT2 Ki
012 and 027 nM for CHO-hMT1 HEK-hMT1CHO-hMT2 and HEK-hMT2 respectively
Purity 9877Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Agomelatine (L(+)-Tartaric acid) (S-20098 L(+)-Tartaric acid) Cat No HY-17038B
Agomelatine L(+)-Tartaric acid (S-20098L(+)-Tartaric acid) is a specific agonist of
and receptors with s of 01 006MT1 MT2 Ki
012 and 027 nM for CHO-hMT1 HEK-hMT1CHO-hMT2 and HEK-hMT2 respectively
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Agomelatine hydrochloride (S-20098 hydrochloride) Cat No HY-17038A
Agomelatine hydrochloride (S-20098 hydrochloride)is a specific agonist of and MT1 MT2receptors with s of 01 006 012 and 027 nMKi
for CHO-hMT1 HEK-hMT1 CHO-hMT2 and HEK-hMT2respectively
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
AlmotriptanCat No HY-B0383A
Almotriptan is a 5-HT1B1D-receptor agonist usedto treat migraine
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Almotriptan malate (PNU180638) Cat No HY-B0383
Almotriptan Malate is a 5-HT1B1D-receptor agonistused to treat migraine
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Alniditan (Alnitidan) Cat No HY-101698
Alniditan is a potent 5-HT receptors1B1D
agonist with of 17 and 13 nM in HEK293IC50
cells and value of 896 and 940 forpKi
5-HT receptors respectively1B1D
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Alosetron (GR 68755 GR 68755X) Cat No HY-70050A
Alosetron (GR 68755) is a potent and highlyselective serotonin antagonist5-HT3 receptorAlosetron is used for the research of irritablebowel syndrome (IBS)
Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 25 mg
wwwMedChemExpresscom 5
Alosetron ((Z)-2-butenedioate) (GR 68755
((Z)-2-butenedioate) GR 68755X ((Z)-2-butenedioate)) Cat No HY-70050B
Alosetron (GR 68755) (Z)-2-butenedioate is apotent and highly selective serotonin 5-HT3
antagonist Alosetron (Z)-2-butenedioatereceptoris used for the research of irritable bowelsyndrome (IBS)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Alosetron (Hydrochloride(1X)) (GR 68755
(Hydrochloride(1X)) GR 68755X (Hydrochloride(1X))) Cat No HY-70050
Alosetron (GR 68755) Hydrochloride(1X) is apotent and highly selective serotonin 5-HT3
antagonist Alosetron Hydrochloride(1X)receptoris used for the research of irritable bowelsyndrome (IBS)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Alosetron Hydrochloride (GR 68755C GR 68755 Hydrochloride
GR 68755X Hydrochloride) Cat No HY-70050C
Alosetron Hydrochloride (GR 68755C) is a potentand highly selective serotonin 5-HT3 receptorantagonist Alosetron Hydrochloride is used forthe research of irritable bowel syndrome (IBS)
Purity 9979Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Alprenolol ((RS)-Alprenolol dl-Alprenolol) Cat No HY-B1517
Alprenolol is a non-selective beta blocker as wellas 5-HT1A receptor antagonist The reference foradministration is 10 mgkg
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg
Alprenolol hydrochloride ((RS)-Alprenolol hydrochloride
dl-Alprenolol hydrochloride) Cat No HY-B1517A
Alprenolol (hydrochloride) is a non-selective betablocker as well as 5-HT1A receptor antagonist Thereference for administration is 10 mgkg
Purity 9958Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Alverine citrate (NSC 35459) Cat No HY-B0500
Alverine citrate is a receptor5-HT1A
antagonist with an of 101 nMIC50
Purity 9943Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Amitriptyline hydrochlorideCat No HY-B0527A
Amitriptyline hydrochloride is an inhibitor of andserotonin reuptake transporter (SERT)
with snoradrenaline reuptake transporter (NET) Ki
of 345 nM and 133 nM for human SERT and NETrespectively
Purity 9956Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ansofaxine hydrochloride (LY03005 LPM570065) Cat No HY-U00096
Ansofaxine hydrochloride (LY03005 LPM570065) is atriple reuptake inhibitor inhibits serotonin
and reuptake with dopamine norepinephrine IC50
values of 723 491 and 763 nM respectively
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 20 mg 50 mg 100 mg
AP521Cat No HY-100166
AP521 is an agonist of human 5-HT receptor1A
with an of 94 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AR-A 2 (AR-A 000002) Cat No HY-107018
AR-A 2 is a selective 5-HT receptor1B
antagonist with high affinity to guinea pigcortex and recombinant guinea pig5HT1B1D
( =024 and 047 nM) and with5-HT receptors1B Ki
10-fold lower affinity to guinea pig 5-HT1D
( 5 nM) and shows an ofhellipreceptor Ki EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Aripiprazole (OPC-14597) Cat No HY-14546
Aripiprazole (OPC-14597) is a human 5-HT1Areceptor partial agonist with a Ki of 42 nM
Purity 9998Clinical Data LaunchedSize 100 mg 200 mg 500 mg 1 g
ArotinololCat No HY-122537A
Arotinolol is a nonselective αβ-adrenergic blocker and a vasodilating β-blockerreceptor
Arotinolol also shows potency for inhibiting thebinding of the radioligand I-ICYP to125
-serotonergic receptor sites5HT1B
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
AS19Cat No HY-103142
AS19 is a potent selective 5-HT receptor7
agonist with an value of 083 nM and a ofIC50 Ki
06 nM AS19 is selective for over5-HT7
5-HT 5-HT 5-HT and 5-HT receptors1A 1B 1D 5A
( s = 897 nM 490 nM 66 nM and 985 nMKi
respectively)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Asenapine (Org 5222) Cat No HY-10121
Asenapine is an antagonist of serotonin receptors(5-HT 5-HT 5-HT 5-HT 5-HT )2A 2B 2C 6 7
(α α α α )adrenoceptors 1 2A 2B 2C
(D D D ) anddopamine receptors 2 3 4
(H H ) with shistamine receptors 1 2 pKi
of 84-105 89-95 89-94 andhellip
Purity 9881Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine hydrochlorideCat No HY-16567
Asenapine hydrochloride an antipsychotic is a (1A 1B 2A 2B 2C 5A 6 7) and 5-HT
receptor antagonist withDopamine (D D D )2 3 4
values of 003-40 nM for 5-HT and 13 042Ki
11 nM for Dopamine receptor respectively
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine maleate (Org 5222 maleate) Cat No HY-11100
Asenapine maleate is a (1A 1B 2A 2B 2C5-HT5A 6 7) and antagonist with values ofD2 Ki
003-40 nM 13nM respectively and anantipsychotic
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg
AsimilobineCat No HY-N7512
Asimilobine is an aporphine isoquinoline alkaloidisolated from plant species of Magnolia obobataThun Asimilobine is a biosynthesisdopamineinhibitor and a antagonistserotonergic receptorAsimilobine shows an andantimalarialanti-cancer activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AVN-492Cat No HY-101924
AVN-492 is a very specific and highly-selectiveantagonist with picomolar affinity to 5-HT6R( =91 pM)Ki
Purity 9949Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Azasetron hydrochloride (Y-25130 hydrochloride) Cat No HY-B0068
Azasetron (Y-25130) hydrochloride a benzamidederivative is a potent and selective 5-HT3receptor antagonist Azasetron is used in thestudy for Chemotherapy-induced nausea and vomiting(CINV)
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Befiradol (NLX-112 F13640) Cat No HY-14785
Befiradol (NLX-112) is a selective 5-HT1Areceptor agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 7
Befiradol hydrochloride (NLX-112 hydrochloride F 13640 hydrochloride) Cat No HY-14785A
Befiradol hydrochloride (NLX-112 hydrochloride) isa selective receptor agonist5-HT1A
Purity 9922Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Bemesetron (MDL 72222) Cat No HY-B1541
Bemesetron (MDL 72222) is a selective 5-HT3
antagonist with an of 033 nMreceptor IC50
Neuroprotective effect
Purity gt990Clinical Data No Development ReportedSize 10 mg
BGC20-761Cat No HY-21995
BGC20-761 is a selecvtive and 5-HT6 dopamine antagonist (human receptor valuesreceptor Ki
5-HT6 (20 nM) 5-HT2A (69 nM) D2 (140 nM)BGC20-761 can enhance long-term memory BGC20-761has potential utility as an antipsychotic agent
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin (AD-5423) Cat No HY-13575
Blonanserin (AD-5423) is a potent and orallyactive ( =0812 nM)5-HT2A Ki
and (dopamine D2enspreceptor Ki
=0142 nM) antagonist
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 100 mg
Blonanserin D5 (AD-5423 D5) Cat No HY-13575S1
Blonanserin D5 (AD-5423 D5) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin D8 (AD-5423 D8) Cat No HY-13575S
Blonanserin D8 (AD-5423 D8) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brexpiprazole (OPC-34712) Cat No HY-15780
Brexpiprazole (OPC-34712) an atypicalantipsychotic drug is a partial agonist of human
and with s of 0125-HT1A dopamine receptor Ki
nM and 03 nM respectively Brexpiprazole is alsoa receptor antagonist with a of 0475-HT2A Ki
nM
Purity 9940Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
Brexpiprazole S-oxide (DM-3411) Cat No HY-133152
Brexpiprazole S-oxide (DM-3411) is a mainmetabolite of Brexpiprazole and is metabolized bycytochrome P450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 5 mg
Brexpiprazole S-oxide D8 (DM-3411 D8) Cat No HY-133152S
Brexpiprazole S-oxide D8 (DM-3411 D8) is adeuterium labeled Brexpiprazole S-oxideBrexpiprazole S-oxide is a main metabolite ofBrexpiprazole and is metabolized by cytochromeP450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brilaroxazine (RP5063) Cat No HY-109112
Brilaroxazine (RP5603) is a potent and orallyactive multimodal dopamine (DA)serotonin
modulator(5-HT)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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BRL 54443Cat No HY-13221
BRL 54443 is a potent receptor agonist5-HT1E1F
( values are 11 nM and 07 nM respectively)Ki
displays gt 30-fold selectivity over other 5-HTand dopamine receptors
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
BRL-15572 dihydrochlorideCat No HY-13200
BRL-15572 dihydrochloride is a selectiveantagonist of displays high affinity forh5-HT1D
BRL-15572 dihydrochlorideh5-HT1D receptorscould be useful pharmacological agents tocharacterise mediated responses5-HT1D receptor
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Bromperidol (R-11333) Cat No HY-B0901
Bromperidol is a butyrophenone derivative is apotent and long-acting neuroleptic used as anantipsychotic in the treatment of schizophrenia
Purity 9802Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Buspirone hydrochlorideCat No HY-B1115
Buspirone hydrochloride is an anxiolyticpsychotropic drug is used to treat generalizedanxiety disorder (GAD)
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Cariprazine (RGH-188) Cat No HY-14763
Cariprazine is a novel antipsychotic drugcandidate that exhibits high affinity for the D3
( =0085 nM) and ( =049 nM) receptors andKi D2 Ki
moderate affinity for the receptor5-HT1A
( =26 nM)Ki
Purity 9935Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg
Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A
Cariprazine hydrochloride is a novel antipsychoticdrug candidate that exhibits high affinity for the
( =0085 nM) and ( =049 nM)D3 Ki D2 Ki
receptors and moderate affinity for the 5-HT1A
receptor ( =26 nM)Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 50 mg
CART(62-76)(humanrat)Cat No HY-P1303
CART(62-76)(humanrat) is a neuropeptide (62-76residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
CART(62-76)(humanrat) TFACat No HY-P1303A
CART(62-76)(humanrat) TFA is a neuropeptide(62-76 residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Chlorpromazine D6 hydrochlorideCat No HY-B0407AS
Chlorpromazine D6 hydrochloride is the deuteriumlabeled Chlorpromazine Chlorpromazine is aninhibitor of dopamine receptor 5-HT receptorpotassium channel sodium channel
Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
Chlorpromazine hydrochlorideCat No HY-B0407A
Chlorpromazine hydrochloride is an antagonist ofthe dopamine D2 5HT2A potassium channeland Chlorpromazine binds with D2sodium channeland 5HT2A with s of 363 nM and 83 nMKi
respectively
Purity 9990Clinical Data LaunchedSize 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Cinanserin hydrochloride (SQ 10643) Cat No HY-100943
Cinanserin hydrochloride (SQ 10643) is a potentselective and highly affinity 5-HT receptor2
antagonist with a of 41 nM CinanserinKi
hydrochloride has a much higher binding affinityfor the than for the 5-HT receptor (5-HT2 1 Ki
of 3500 nM)
Purity 9974Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
cis-(Z)-Flupentixol dihydrochloride (cis-(Z)-Flupenthixol dihydrochloride) Cat No HY-15856
cis-(Z)-Flupentixol dihydrochloride is a potentand selective antagonist withDA D1D2 receptor
values of 038 nM and 7 nM for D2 receptor andKi
respectively5-HT2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
cis-Urocanic acid ((Z)-Urocanic acid cis-UCA) Cat No HY-113008A
cis-Urocanic acid is a agonist5-HT2A receptorcis-Urocanic acid binds to with5-HT receptorrelatively high affinity ( =46 nM)Kd
cis-Urocanic acid is an immune modulator thatinduces immunosuppression by binding to the 5-HT2Areceptor
Purity 9992Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg
Cisapride (R 51619 (plusmn)-Cisaprid) Cat No HY-14149
Cisapride(R 51619) is a nonselective 5-HT4receptor agonist it is also a potent hERGpotassium channel inhibitor
Purity 9972Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073
Clocapramine is an antagonist of the D2
5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A
Clocapramine hydrochloride hydrate is anantagonist of the and D2 5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
CP-809101 hydrochlorideCat No HY-15543A
CP-809101 hydrochloride is a potent and selective5-HT2C receptor agonist with pEC50 of996719681 for human 5-HT2C5-HT2B5-HT2Areceptors respectively
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
CyamemazineCat No HY-14264
Cyamemazine is a neuroleptic agent that containsthe phenothiazine chromophore Cyamemazine isoften used as an anxiolytic Cyamemazine is apotent ( of 12 nM) ( = 155-HT3 Ki 5-HT2A Ki
nM) and ( of 75 nM) receptors5-HT2C Ki
antagonist with antipsychotic activity
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Cyclobenzaprine hydrochloride (MK130 hydrochloride) Cat No HY-B0740
Cyclobenzaprine hydrochloride (MK130hydrochloride) is a skeletal muscle relaxant and acentral nervous system (CNS) depressant Target5-HT Receptor 2A Cyclobenzaprine hydrochloride isa skeletal muscle relaxant and a central nervoussystem (CNS) depressant
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Cyproheptadine hydrochlorideCat No HY-B0366A
Cyproheptadine hydrochloride is a 5-HT2A
antagonist with antidepressant andreceptorantiserotonergic effects Cyproheptadinehydrochloride has antiplatelet andthromboprotective activities
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg 1 g
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Cyproheptadine hydrochloride sesquihydrateCat No HY-B1165
Cyproheptadine hydrochloride sesquihydrate is anantihistamine and is an antagonist of serotoninand histamine2
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
Dehydroaripiprazole (OPC-14857 DM-14857) Cat No HY-100665
Dehydroaripiprazole (OPC-14857) is an activemetabolite of Aripiprazole Aripiprazole is anantipsychotic agent and is metabolized by CYP3A4and CYP2D6 forming mainly DehydroaripiprazoleDehydroaripiprazole has with antipsychoticactivity equivalent to Aripiprazole
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Deramciclane (EGIS-3886) Cat No HY-101630
Deramciclane has a high affinity for and5-HT2A
receptors it acts as an antagonist at5-HT2C
both receptor subtypes and has inverse agonistproperties at the 5-HT receptors without direct2C
stimulatory agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Dihydroergotamine mesylateCat No HY-B0670A
Dihydroergotamine mesylate is an ergot alkaloidused to treat migraines
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Dolasetron (MDL-73147) Cat No HY-B0750
Dolasetron(MDL-73147) is a serotonin 5-HT3receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
Dolasetron Mesylate (MDL-73147EF) Cat No HY-B0750A
Dolasetron Mesylate (MDL-73147EF) is a serotonin5-HT3 receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) Cat No HY-B0750B
Dolasetron Mesylate hydrate (MDL-73147EF hydrate)is a serotonin 5-HT3 receptor antagonist used totreat nausea and vomiting following chemotherapy
Purity gt990Clinical Data LaunchedSize 100 mg 200 mg
DonitriptanCat No HY-106157
Donitriptan is a potent high efficacy agonist ats with s of 94 and 935-HT receptor1B1D pKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eletriptan hydrobromide (Eletriptan HBr) Cat No HY-A0010
Eletriptan HBr is a selective 5-HT1B and 5-HT1Dreceptor agonist with Ki of 092 nM and 314 nMrespectively
Purity 9513Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Eltoprazine (DU 28853) Cat No HY-16687
Eltoprazine(DU28853) is a serenic orantiaggressive agent which as an agonist at the5-HT1A and 5-HT1B receptors and as an antagonistat the 5-HT2C receptor
Purity gt950Clinical Data Phase 2Size 1 mg 5 mg
wwwMedChemExpresscom 11
Eltoprazine hydrochloride (DU 28853 hydrochloride) Cat No HY-16687A
Eltoprazine hydrochloride (DU 28853 hydrochloride)is a serenic or antiaggressive agent which as anagonist at the 5-HT1A and 5-HT1B receptors and asan antagonist at the 5-HT2C receptor
Purity 9985Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
EMD 56551Cat No HY-19134
EMD 56551 is a potent and selective 5-HT1A agonist EMD 56551 exerts anxiolyticreceptor
activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eplivanserin (SR-46349) Cat No HY-10792
Eplivanserin is a potent selective and orallyavailable antagonist with an5-HT receptor2
of 58 nM in rat cortical membrane and aIC50
of 114 nMKd
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Eplivanserin (mixture) (SR-46349 (mixture)) Cat No HY-10792A
Eplivanserin mixture (SR-46349 mixture) is aselective inhibitor and aserotonin reuptake
antagonist extracted from5-HT receptor2A
patent WO 2005002578 A1
Purity 9995Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Eptapirone (F 11440) Cat No HY-19946
Eptapirone (F11440) is a potent selective highefficacy 5-HT1A receptor agonist with markedanxiolytic and antidepressant potential
Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
F-15599 (NLX-101) Cat No HY-19863
F-15599 is a highly selective G-protein biased agonist with of 34 nM5-HT1A receptor Ki
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Fabesetron (FK1052 free base) Cat No HY-105201
Fabesetron (FK1052) is an orally active 5-HT3
antagonist with receptor 5-HT receptor4
antagonistic activity Fabesetron (FK1052) can beused in the study for both acute and delayedemesis induced by cancer chemotherapy
Purity 9572Clinical Data No Development ReportedSize 1 mg 5 mg
Facinicline hydrochloride (RG3487 hydrochloride) Cat No HY-108057A
Facinicline hydrochloride (RG3487 hydrochloride)is an orally active partialnicotinic α7 receptoragonist with a of 6 nM for α7 human nAChRKi
Facinicline hydrochloride (RG3487 hydrochloride)improves cognition and sensorimotor gating inrodents
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Fananserin (RP 62203) Cat No HY-103104
Fananserin (RP 62203) is an orally bioavailablepotent and selective 5-hydroxytryptamine2
receptor antagonist with a of 037(5-HT )2 Ki
nM for the rat 5-HT receptor2A
Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
FlesinoxanCat No HY-121653
Flesinoxan is a hypotensive agent and a potenthigh affinity and selective5-hydroxytryptamine1A (5-HT1A) receptoragonist with an value of 24 nM FlesinoxanEC50
also has effective anxiolyticantidepressanteffects
Purity 9907Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 1 g
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Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
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LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
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Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
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Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
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Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
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Alosetron ((Z)-2-butenedioate) (GR 68755
((Z)-2-butenedioate) GR 68755X ((Z)-2-butenedioate)) Cat No HY-70050B
Alosetron (GR 68755) (Z)-2-butenedioate is apotent and highly selective serotonin 5-HT3
antagonist Alosetron (Z)-2-butenedioatereceptoris used for the research of irritable bowelsyndrome (IBS)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Alosetron (Hydrochloride(1X)) (GR 68755
(Hydrochloride(1X)) GR 68755X (Hydrochloride(1X))) Cat No HY-70050
Alosetron (GR 68755) Hydrochloride(1X) is apotent and highly selective serotonin 5-HT3
antagonist Alosetron Hydrochloride(1X)receptoris used for the research of irritable bowelsyndrome (IBS)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Alosetron Hydrochloride (GR 68755C GR 68755 Hydrochloride
GR 68755X Hydrochloride) Cat No HY-70050C
Alosetron Hydrochloride (GR 68755C) is a potentand highly selective serotonin 5-HT3 receptorantagonist Alosetron Hydrochloride is used forthe research of irritable bowel syndrome (IBS)
Purity 9979Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Alprenolol ((RS)-Alprenolol dl-Alprenolol) Cat No HY-B1517
Alprenolol is a non-selective beta blocker as wellas 5-HT1A receptor antagonist The reference foradministration is 10 mgkg
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg
Alprenolol hydrochloride ((RS)-Alprenolol hydrochloride
dl-Alprenolol hydrochloride) Cat No HY-B1517A
Alprenolol (hydrochloride) is a non-selective betablocker as well as 5-HT1A receptor antagonist Thereference for administration is 10 mgkg
Purity 9958Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Alverine citrate (NSC 35459) Cat No HY-B0500
Alverine citrate is a receptor5-HT1A
antagonist with an of 101 nMIC50
Purity 9943Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Amitriptyline hydrochlorideCat No HY-B0527A
Amitriptyline hydrochloride is an inhibitor of andserotonin reuptake transporter (SERT)
with snoradrenaline reuptake transporter (NET) Ki
of 345 nM and 133 nM for human SERT and NETrespectively
Purity 9956Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ansofaxine hydrochloride (LY03005 LPM570065) Cat No HY-U00096
Ansofaxine hydrochloride (LY03005 LPM570065) is atriple reuptake inhibitor inhibits serotonin
and reuptake with dopamine norepinephrine IC50
values of 723 491 and 763 nM respectively
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 20 mg 50 mg 100 mg
AP521Cat No HY-100166
AP521 is an agonist of human 5-HT receptor1A
with an of 94 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AR-A 2 (AR-A 000002) Cat No HY-107018
AR-A 2 is a selective 5-HT receptor1B
antagonist with high affinity to guinea pigcortex and recombinant guinea pig5HT1B1D
( =024 and 047 nM) and with5-HT receptors1B Ki
10-fold lower affinity to guinea pig 5-HT1D
( 5 nM) and shows an ofhellipreceptor Ki EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Aripiprazole (OPC-14597) Cat No HY-14546
Aripiprazole (OPC-14597) is a human 5-HT1Areceptor partial agonist with a Ki of 42 nM
Purity 9998Clinical Data LaunchedSize 100 mg 200 mg 500 mg 1 g
ArotinololCat No HY-122537A
Arotinolol is a nonselective αβ-adrenergic blocker and a vasodilating β-blockerreceptor
Arotinolol also shows potency for inhibiting thebinding of the radioligand I-ICYP to125
-serotonergic receptor sites5HT1B
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
AS19Cat No HY-103142
AS19 is a potent selective 5-HT receptor7
agonist with an value of 083 nM and a ofIC50 Ki
06 nM AS19 is selective for over5-HT7
5-HT 5-HT 5-HT and 5-HT receptors1A 1B 1D 5A
( s = 897 nM 490 nM 66 nM and 985 nMKi
respectively)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Asenapine (Org 5222) Cat No HY-10121
Asenapine is an antagonist of serotonin receptors(5-HT 5-HT 5-HT 5-HT 5-HT )2A 2B 2C 6 7
(α α α α )adrenoceptors 1 2A 2B 2C
(D D D ) anddopamine receptors 2 3 4
(H H ) with shistamine receptors 1 2 pKi
of 84-105 89-95 89-94 andhellip
Purity 9881Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine hydrochlorideCat No HY-16567
Asenapine hydrochloride an antipsychotic is a (1A 1B 2A 2B 2C 5A 6 7) and 5-HT
receptor antagonist withDopamine (D D D )2 3 4
values of 003-40 nM for 5-HT and 13 042Ki
11 nM for Dopamine receptor respectively
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine maleate (Org 5222 maleate) Cat No HY-11100
Asenapine maleate is a (1A 1B 2A 2B 2C5-HT5A 6 7) and antagonist with values ofD2 Ki
003-40 nM 13nM respectively and anantipsychotic
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg
AsimilobineCat No HY-N7512
Asimilobine is an aporphine isoquinoline alkaloidisolated from plant species of Magnolia obobataThun Asimilobine is a biosynthesisdopamineinhibitor and a antagonistserotonergic receptorAsimilobine shows an andantimalarialanti-cancer activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AVN-492Cat No HY-101924
AVN-492 is a very specific and highly-selectiveantagonist with picomolar affinity to 5-HT6R( =91 pM)Ki
Purity 9949Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Azasetron hydrochloride (Y-25130 hydrochloride) Cat No HY-B0068
Azasetron (Y-25130) hydrochloride a benzamidederivative is a potent and selective 5-HT3receptor antagonist Azasetron is used in thestudy for Chemotherapy-induced nausea and vomiting(CINV)
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Befiradol (NLX-112 F13640) Cat No HY-14785
Befiradol (NLX-112) is a selective 5-HT1Areceptor agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 7
Befiradol hydrochloride (NLX-112 hydrochloride F 13640 hydrochloride) Cat No HY-14785A
Befiradol hydrochloride (NLX-112 hydrochloride) isa selective receptor agonist5-HT1A
Purity 9922Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Bemesetron (MDL 72222) Cat No HY-B1541
Bemesetron (MDL 72222) is a selective 5-HT3
antagonist with an of 033 nMreceptor IC50
Neuroprotective effect
Purity gt990Clinical Data No Development ReportedSize 10 mg
BGC20-761Cat No HY-21995
BGC20-761 is a selecvtive and 5-HT6 dopamine antagonist (human receptor valuesreceptor Ki
5-HT6 (20 nM) 5-HT2A (69 nM) D2 (140 nM)BGC20-761 can enhance long-term memory BGC20-761has potential utility as an antipsychotic agent
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin (AD-5423) Cat No HY-13575
Blonanserin (AD-5423) is a potent and orallyactive ( =0812 nM)5-HT2A Ki
and (dopamine D2enspreceptor Ki
=0142 nM) antagonist
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 100 mg
Blonanserin D5 (AD-5423 D5) Cat No HY-13575S1
Blonanserin D5 (AD-5423 D5) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin D8 (AD-5423 D8) Cat No HY-13575S
Blonanserin D8 (AD-5423 D8) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brexpiprazole (OPC-34712) Cat No HY-15780
Brexpiprazole (OPC-34712) an atypicalantipsychotic drug is a partial agonist of human
and with s of 0125-HT1A dopamine receptor Ki
nM and 03 nM respectively Brexpiprazole is alsoa receptor antagonist with a of 0475-HT2A Ki
nM
Purity 9940Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
Brexpiprazole S-oxide (DM-3411) Cat No HY-133152
Brexpiprazole S-oxide (DM-3411) is a mainmetabolite of Brexpiprazole and is metabolized bycytochrome P450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 5 mg
Brexpiprazole S-oxide D8 (DM-3411 D8) Cat No HY-133152S
Brexpiprazole S-oxide D8 (DM-3411 D8) is adeuterium labeled Brexpiprazole S-oxideBrexpiprazole S-oxide is a main metabolite ofBrexpiprazole and is metabolized by cytochromeP450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brilaroxazine (RP5063) Cat No HY-109112
Brilaroxazine (RP5603) is a potent and orallyactive multimodal dopamine (DA)serotonin
modulator(5-HT)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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BRL 54443Cat No HY-13221
BRL 54443 is a potent receptor agonist5-HT1E1F
( values are 11 nM and 07 nM respectively)Ki
displays gt 30-fold selectivity over other 5-HTand dopamine receptors
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
BRL-15572 dihydrochlorideCat No HY-13200
BRL-15572 dihydrochloride is a selectiveantagonist of displays high affinity forh5-HT1D
BRL-15572 dihydrochlorideh5-HT1D receptorscould be useful pharmacological agents tocharacterise mediated responses5-HT1D receptor
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Bromperidol (R-11333) Cat No HY-B0901
Bromperidol is a butyrophenone derivative is apotent and long-acting neuroleptic used as anantipsychotic in the treatment of schizophrenia
Purity 9802Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Buspirone hydrochlorideCat No HY-B1115
Buspirone hydrochloride is an anxiolyticpsychotropic drug is used to treat generalizedanxiety disorder (GAD)
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Cariprazine (RGH-188) Cat No HY-14763
Cariprazine is a novel antipsychotic drugcandidate that exhibits high affinity for the D3
( =0085 nM) and ( =049 nM) receptors andKi D2 Ki
moderate affinity for the receptor5-HT1A
( =26 nM)Ki
Purity 9935Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg
Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A
Cariprazine hydrochloride is a novel antipsychoticdrug candidate that exhibits high affinity for the
( =0085 nM) and ( =049 nM)D3 Ki D2 Ki
receptors and moderate affinity for the 5-HT1A
receptor ( =26 nM)Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 50 mg
CART(62-76)(humanrat)Cat No HY-P1303
CART(62-76)(humanrat) is a neuropeptide (62-76residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
CART(62-76)(humanrat) TFACat No HY-P1303A
CART(62-76)(humanrat) TFA is a neuropeptide(62-76 residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Chlorpromazine D6 hydrochlorideCat No HY-B0407AS
Chlorpromazine D6 hydrochloride is the deuteriumlabeled Chlorpromazine Chlorpromazine is aninhibitor of dopamine receptor 5-HT receptorpotassium channel sodium channel
Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
Chlorpromazine hydrochlorideCat No HY-B0407A
Chlorpromazine hydrochloride is an antagonist ofthe dopamine D2 5HT2A potassium channeland Chlorpromazine binds with D2sodium channeland 5HT2A with s of 363 nM and 83 nMKi
respectively
Purity 9990Clinical Data LaunchedSize 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Cinanserin hydrochloride (SQ 10643) Cat No HY-100943
Cinanserin hydrochloride (SQ 10643) is a potentselective and highly affinity 5-HT receptor2
antagonist with a of 41 nM CinanserinKi
hydrochloride has a much higher binding affinityfor the than for the 5-HT receptor (5-HT2 1 Ki
of 3500 nM)
Purity 9974Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
cis-(Z)-Flupentixol dihydrochloride (cis-(Z)-Flupenthixol dihydrochloride) Cat No HY-15856
cis-(Z)-Flupentixol dihydrochloride is a potentand selective antagonist withDA D1D2 receptor
values of 038 nM and 7 nM for D2 receptor andKi
respectively5-HT2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
cis-Urocanic acid ((Z)-Urocanic acid cis-UCA) Cat No HY-113008A
cis-Urocanic acid is a agonist5-HT2A receptorcis-Urocanic acid binds to with5-HT receptorrelatively high affinity ( =46 nM)Kd
cis-Urocanic acid is an immune modulator thatinduces immunosuppression by binding to the 5-HT2Areceptor
Purity 9992Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg
Cisapride (R 51619 (plusmn)-Cisaprid) Cat No HY-14149
Cisapride(R 51619) is a nonselective 5-HT4receptor agonist it is also a potent hERGpotassium channel inhibitor
Purity 9972Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073
Clocapramine is an antagonist of the D2
5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A
Clocapramine hydrochloride hydrate is anantagonist of the and D2 5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
CP-809101 hydrochlorideCat No HY-15543A
CP-809101 hydrochloride is a potent and selective5-HT2C receptor agonist with pEC50 of996719681 for human 5-HT2C5-HT2B5-HT2Areceptors respectively
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
CyamemazineCat No HY-14264
Cyamemazine is a neuroleptic agent that containsthe phenothiazine chromophore Cyamemazine isoften used as an anxiolytic Cyamemazine is apotent ( of 12 nM) ( = 155-HT3 Ki 5-HT2A Ki
nM) and ( of 75 nM) receptors5-HT2C Ki
antagonist with antipsychotic activity
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Cyclobenzaprine hydrochloride (MK130 hydrochloride) Cat No HY-B0740
Cyclobenzaprine hydrochloride (MK130hydrochloride) is a skeletal muscle relaxant and acentral nervous system (CNS) depressant Target5-HT Receptor 2A Cyclobenzaprine hydrochloride isa skeletal muscle relaxant and a central nervoussystem (CNS) depressant
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Cyproheptadine hydrochlorideCat No HY-B0366A
Cyproheptadine hydrochloride is a 5-HT2A
antagonist with antidepressant andreceptorantiserotonergic effects Cyproheptadinehydrochloride has antiplatelet andthromboprotective activities
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg 1 g
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Cyproheptadine hydrochloride sesquihydrateCat No HY-B1165
Cyproheptadine hydrochloride sesquihydrate is anantihistamine and is an antagonist of serotoninand histamine2
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
Dehydroaripiprazole (OPC-14857 DM-14857) Cat No HY-100665
Dehydroaripiprazole (OPC-14857) is an activemetabolite of Aripiprazole Aripiprazole is anantipsychotic agent and is metabolized by CYP3A4and CYP2D6 forming mainly DehydroaripiprazoleDehydroaripiprazole has with antipsychoticactivity equivalent to Aripiprazole
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Deramciclane (EGIS-3886) Cat No HY-101630
Deramciclane has a high affinity for and5-HT2A
receptors it acts as an antagonist at5-HT2C
both receptor subtypes and has inverse agonistproperties at the 5-HT receptors without direct2C
stimulatory agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Dihydroergotamine mesylateCat No HY-B0670A
Dihydroergotamine mesylate is an ergot alkaloidused to treat migraines
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Dolasetron (MDL-73147) Cat No HY-B0750
Dolasetron(MDL-73147) is a serotonin 5-HT3receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
Dolasetron Mesylate (MDL-73147EF) Cat No HY-B0750A
Dolasetron Mesylate (MDL-73147EF) is a serotonin5-HT3 receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) Cat No HY-B0750B
Dolasetron Mesylate hydrate (MDL-73147EF hydrate)is a serotonin 5-HT3 receptor antagonist used totreat nausea and vomiting following chemotherapy
Purity gt990Clinical Data LaunchedSize 100 mg 200 mg
DonitriptanCat No HY-106157
Donitriptan is a potent high efficacy agonist ats with s of 94 and 935-HT receptor1B1D pKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eletriptan hydrobromide (Eletriptan HBr) Cat No HY-A0010
Eletriptan HBr is a selective 5-HT1B and 5-HT1Dreceptor agonist with Ki of 092 nM and 314 nMrespectively
Purity 9513Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Eltoprazine (DU 28853) Cat No HY-16687
Eltoprazine(DU28853) is a serenic orantiaggressive agent which as an agonist at the5-HT1A and 5-HT1B receptors and as an antagonistat the 5-HT2C receptor
Purity gt950Clinical Data Phase 2Size 1 mg 5 mg
wwwMedChemExpresscom 11
Eltoprazine hydrochloride (DU 28853 hydrochloride) Cat No HY-16687A
Eltoprazine hydrochloride (DU 28853 hydrochloride)is a serenic or antiaggressive agent which as anagonist at the 5-HT1A and 5-HT1B receptors and asan antagonist at the 5-HT2C receptor
Purity 9985Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
EMD 56551Cat No HY-19134
EMD 56551 is a potent and selective 5-HT1A agonist EMD 56551 exerts anxiolyticreceptor
activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eplivanserin (SR-46349) Cat No HY-10792
Eplivanserin is a potent selective and orallyavailable antagonist with an5-HT receptor2
of 58 nM in rat cortical membrane and aIC50
of 114 nMKd
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Eplivanserin (mixture) (SR-46349 (mixture)) Cat No HY-10792A
Eplivanserin mixture (SR-46349 mixture) is aselective inhibitor and aserotonin reuptake
antagonist extracted from5-HT receptor2A
patent WO 2005002578 A1
Purity 9995Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Eptapirone (F 11440) Cat No HY-19946
Eptapirone (F11440) is a potent selective highefficacy 5-HT1A receptor agonist with markedanxiolytic and antidepressant potential
Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
F-15599 (NLX-101) Cat No HY-19863
F-15599 is a highly selective G-protein biased agonist with of 34 nM5-HT1A receptor Ki
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Fabesetron (FK1052 free base) Cat No HY-105201
Fabesetron (FK1052) is an orally active 5-HT3
antagonist with receptor 5-HT receptor4
antagonistic activity Fabesetron (FK1052) can beused in the study for both acute and delayedemesis induced by cancer chemotherapy
Purity 9572Clinical Data No Development ReportedSize 1 mg 5 mg
Facinicline hydrochloride (RG3487 hydrochloride) Cat No HY-108057A
Facinicline hydrochloride (RG3487 hydrochloride)is an orally active partialnicotinic α7 receptoragonist with a of 6 nM for α7 human nAChRKi
Facinicline hydrochloride (RG3487 hydrochloride)improves cognition and sensorimotor gating inrodents
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Fananserin (RP 62203) Cat No HY-103104
Fananserin (RP 62203) is an orally bioavailablepotent and selective 5-hydroxytryptamine2
receptor antagonist with a of 037(5-HT )2 Ki
nM for the rat 5-HT receptor2A
Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
FlesinoxanCat No HY-121653
Flesinoxan is a hypotensive agent and a potenthigh affinity and selective5-hydroxytryptamine1A (5-HT1A) receptoragonist with an value of 24 nM FlesinoxanEC50
also has effective anxiolyticantidepressanteffects
Purity 9907Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 1 g
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
18 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Aripiprazole (OPC-14597) Cat No HY-14546
Aripiprazole (OPC-14597) is a human 5-HT1Areceptor partial agonist with a Ki of 42 nM
Purity 9998Clinical Data LaunchedSize 100 mg 200 mg 500 mg 1 g
ArotinololCat No HY-122537A
Arotinolol is a nonselective αβ-adrenergic blocker and a vasodilating β-blockerreceptor
Arotinolol also shows potency for inhibiting thebinding of the radioligand I-ICYP to125
-serotonergic receptor sites5HT1B
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
AS19Cat No HY-103142
AS19 is a potent selective 5-HT receptor7
agonist with an value of 083 nM and a ofIC50 Ki
06 nM AS19 is selective for over5-HT7
5-HT 5-HT 5-HT and 5-HT receptors1A 1B 1D 5A
( s = 897 nM 490 nM 66 nM and 985 nMKi
respectively)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Asenapine (Org 5222) Cat No HY-10121
Asenapine is an antagonist of serotonin receptors(5-HT 5-HT 5-HT 5-HT 5-HT )2A 2B 2C 6 7
(α α α α )adrenoceptors 1 2A 2B 2C
(D D D ) anddopamine receptors 2 3 4
(H H ) with shistamine receptors 1 2 pKi
of 84-105 89-95 89-94 andhellip
Purity 9881Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine hydrochlorideCat No HY-16567
Asenapine hydrochloride an antipsychotic is a (1A 1B 2A 2B 2C 5A 6 7) and 5-HT
receptor antagonist withDopamine (D D D )2 3 4
values of 003-40 nM for 5-HT and 13 042Ki
11 nM for Dopamine receptor respectively
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Asenapine maleate (Org 5222 maleate) Cat No HY-11100
Asenapine maleate is a (1A 1B 2A 2B 2C5-HT5A 6 7) and antagonist with values ofD2 Ki
003-40 nM 13nM respectively and anantipsychotic
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg
AsimilobineCat No HY-N7512
Asimilobine is an aporphine isoquinoline alkaloidisolated from plant species of Magnolia obobataThun Asimilobine is a biosynthesisdopamineinhibitor and a antagonistserotonergic receptorAsimilobine shows an andantimalarialanti-cancer activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AVN-492Cat No HY-101924
AVN-492 is a very specific and highly-selectiveantagonist with picomolar affinity to 5-HT6R( =91 pM)Ki
Purity 9949Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Azasetron hydrochloride (Y-25130 hydrochloride) Cat No HY-B0068
Azasetron (Y-25130) hydrochloride a benzamidederivative is a potent and selective 5-HT3receptor antagonist Azasetron is used in thestudy for Chemotherapy-induced nausea and vomiting(CINV)
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Befiradol (NLX-112 F13640) Cat No HY-14785
Befiradol (NLX-112) is a selective 5-HT1Areceptor agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 7
Befiradol hydrochloride (NLX-112 hydrochloride F 13640 hydrochloride) Cat No HY-14785A
Befiradol hydrochloride (NLX-112 hydrochloride) isa selective receptor agonist5-HT1A
Purity 9922Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Bemesetron (MDL 72222) Cat No HY-B1541
Bemesetron (MDL 72222) is a selective 5-HT3
antagonist with an of 033 nMreceptor IC50
Neuroprotective effect
Purity gt990Clinical Data No Development ReportedSize 10 mg
BGC20-761Cat No HY-21995
BGC20-761 is a selecvtive and 5-HT6 dopamine antagonist (human receptor valuesreceptor Ki
5-HT6 (20 nM) 5-HT2A (69 nM) D2 (140 nM)BGC20-761 can enhance long-term memory BGC20-761has potential utility as an antipsychotic agent
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin (AD-5423) Cat No HY-13575
Blonanserin (AD-5423) is a potent and orallyactive ( =0812 nM)5-HT2A Ki
and (dopamine D2enspreceptor Ki
=0142 nM) antagonist
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 100 mg
Blonanserin D5 (AD-5423 D5) Cat No HY-13575S1
Blonanserin D5 (AD-5423 D5) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin D8 (AD-5423 D8) Cat No HY-13575S
Blonanserin D8 (AD-5423 D8) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brexpiprazole (OPC-34712) Cat No HY-15780
Brexpiprazole (OPC-34712) an atypicalantipsychotic drug is a partial agonist of human
and with s of 0125-HT1A dopamine receptor Ki
nM and 03 nM respectively Brexpiprazole is alsoa receptor antagonist with a of 0475-HT2A Ki
nM
Purity 9940Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
Brexpiprazole S-oxide (DM-3411) Cat No HY-133152
Brexpiprazole S-oxide (DM-3411) is a mainmetabolite of Brexpiprazole and is metabolized bycytochrome P450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 5 mg
Brexpiprazole S-oxide D8 (DM-3411 D8) Cat No HY-133152S
Brexpiprazole S-oxide D8 (DM-3411 D8) is adeuterium labeled Brexpiprazole S-oxideBrexpiprazole S-oxide is a main metabolite ofBrexpiprazole and is metabolized by cytochromeP450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brilaroxazine (RP5063) Cat No HY-109112
Brilaroxazine (RP5603) is a potent and orallyactive multimodal dopamine (DA)serotonin
modulator(5-HT)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
BRL 54443Cat No HY-13221
BRL 54443 is a potent receptor agonist5-HT1E1F
( values are 11 nM and 07 nM respectively)Ki
displays gt 30-fold selectivity over other 5-HTand dopamine receptors
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
BRL-15572 dihydrochlorideCat No HY-13200
BRL-15572 dihydrochloride is a selectiveantagonist of displays high affinity forh5-HT1D
BRL-15572 dihydrochlorideh5-HT1D receptorscould be useful pharmacological agents tocharacterise mediated responses5-HT1D receptor
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Bromperidol (R-11333) Cat No HY-B0901
Bromperidol is a butyrophenone derivative is apotent and long-acting neuroleptic used as anantipsychotic in the treatment of schizophrenia
Purity 9802Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Buspirone hydrochlorideCat No HY-B1115
Buspirone hydrochloride is an anxiolyticpsychotropic drug is used to treat generalizedanxiety disorder (GAD)
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Cariprazine (RGH-188) Cat No HY-14763
Cariprazine is a novel antipsychotic drugcandidate that exhibits high affinity for the D3
( =0085 nM) and ( =049 nM) receptors andKi D2 Ki
moderate affinity for the receptor5-HT1A
( =26 nM)Ki
Purity 9935Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg
Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A
Cariprazine hydrochloride is a novel antipsychoticdrug candidate that exhibits high affinity for the
( =0085 nM) and ( =049 nM)D3 Ki D2 Ki
receptors and moderate affinity for the 5-HT1A
receptor ( =26 nM)Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 50 mg
CART(62-76)(humanrat)Cat No HY-P1303
CART(62-76)(humanrat) is a neuropeptide (62-76residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
CART(62-76)(humanrat) TFACat No HY-P1303A
CART(62-76)(humanrat) TFA is a neuropeptide(62-76 residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Chlorpromazine D6 hydrochlorideCat No HY-B0407AS
Chlorpromazine D6 hydrochloride is the deuteriumlabeled Chlorpromazine Chlorpromazine is aninhibitor of dopamine receptor 5-HT receptorpotassium channel sodium channel
Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
Chlorpromazine hydrochlorideCat No HY-B0407A
Chlorpromazine hydrochloride is an antagonist ofthe dopamine D2 5HT2A potassium channeland Chlorpromazine binds with D2sodium channeland 5HT2A with s of 363 nM and 83 nMKi
respectively
Purity 9990Clinical Data LaunchedSize 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Cinanserin hydrochloride (SQ 10643) Cat No HY-100943
Cinanserin hydrochloride (SQ 10643) is a potentselective and highly affinity 5-HT receptor2
antagonist with a of 41 nM CinanserinKi
hydrochloride has a much higher binding affinityfor the than for the 5-HT receptor (5-HT2 1 Ki
of 3500 nM)
Purity 9974Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
cis-(Z)-Flupentixol dihydrochloride (cis-(Z)-Flupenthixol dihydrochloride) Cat No HY-15856
cis-(Z)-Flupentixol dihydrochloride is a potentand selective antagonist withDA D1D2 receptor
values of 038 nM and 7 nM for D2 receptor andKi
respectively5-HT2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
cis-Urocanic acid ((Z)-Urocanic acid cis-UCA) Cat No HY-113008A
cis-Urocanic acid is a agonist5-HT2A receptorcis-Urocanic acid binds to with5-HT receptorrelatively high affinity ( =46 nM)Kd
cis-Urocanic acid is an immune modulator thatinduces immunosuppression by binding to the 5-HT2Areceptor
Purity 9992Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg
Cisapride (R 51619 (plusmn)-Cisaprid) Cat No HY-14149
Cisapride(R 51619) is a nonselective 5-HT4receptor agonist it is also a potent hERGpotassium channel inhibitor
Purity 9972Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073
Clocapramine is an antagonist of the D2
5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A
Clocapramine hydrochloride hydrate is anantagonist of the and D2 5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
CP-809101 hydrochlorideCat No HY-15543A
CP-809101 hydrochloride is a potent and selective5-HT2C receptor agonist with pEC50 of996719681 for human 5-HT2C5-HT2B5-HT2Areceptors respectively
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
CyamemazineCat No HY-14264
Cyamemazine is a neuroleptic agent that containsthe phenothiazine chromophore Cyamemazine isoften used as an anxiolytic Cyamemazine is apotent ( of 12 nM) ( = 155-HT3 Ki 5-HT2A Ki
nM) and ( of 75 nM) receptors5-HT2C Ki
antagonist with antipsychotic activity
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Cyclobenzaprine hydrochloride (MK130 hydrochloride) Cat No HY-B0740
Cyclobenzaprine hydrochloride (MK130hydrochloride) is a skeletal muscle relaxant and acentral nervous system (CNS) depressant Target5-HT Receptor 2A Cyclobenzaprine hydrochloride isa skeletal muscle relaxant and a central nervoussystem (CNS) depressant
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Cyproheptadine hydrochlorideCat No HY-B0366A
Cyproheptadine hydrochloride is a 5-HT2A
antagonist with antidepressant andreceptorantiserotonergic effects Cyproheptadinehydrochloride has antiplatelet andthromboprotective activities
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg 1 g
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Cyproheptadine hydrochloride sesquihydrateCat No HY-B1165
Cyproheptadine hydrochloride sesquihydrate is anantihistamine and is an antagonist of serotoninand histamine2
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
Dehydroaripiprazole (OPC-14857 DM-14857) Cat No HY-100665
Dehydroaripiprazole (OPC-14857) is an activemetabolite of Aripiprazole Aripiprazole is anantipsychotic agent and is metabolized by CYP3A4and CYP2D6 forming mainly DehydroaripiprazoleDehydroaripiprazole has with antipsychoticactivity equivalent to Aripiprazole
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Deramciclane (EGIS-3886) Cat No HY-101630
Deramciclane has a high affinity for and5-HT2A
receptors it acts as an antagonist at5-HT2C
both receptor subtypes and has inverse agonistproperties at the 5-HT receptors without direct2C
stimulatory agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Dihydroergotamine mesylateCat No HY-B0670A
Dihydroergotamine mesylate is an ergot alkaloidused to treat migraines
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Dolasetron (MDL-73147) Cat No HY-B0750
Dolasetron(MDL-73147) is a serotonin 5-HT3receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
Dolasetron Mesylate (MDL-73147EF) Cat No HY-B0750A
Dolasetron Mesylate (MDL-73147EF) is a serotonin5-HT3 receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) Cat No HY-B0750B
Dolasetron Mesylate hydrate (MDL-73147EF hydrate)is a serotonin 5-HT3 receptor antagonist used totreat nausea and vomiting following chemotherapy
Purity gt990Clinical Data LaunchedSize 100 mg 200 mg
DonitriptanCat No HY-106157
Donitriptan is a potent high efficacy agonist ats with s of 94 and 935-HT receptor1B1D pKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eletriptan hydrobromide (Eletriptan HBr) Cat No HY-A0010
Eletriptan HBr is a selective 5-HT1B and 5-HT1Dreceptor agonist with Ki of 092 nM and 314 nMrespectively
Purity 9513Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Eltoprazine (DU 28853) Cat No HY-16687
Eltoprazine(DU28853) is a serenic orantiaggressive agent which as an agonist at the5-HT1A and 5-HT1B receptors and as an antagonistat the 5-HT2C receptor
Purity gt950Clinical Data Phase 2Size 1 mg 5 mg
wwwMedChemExpresscom 11
Eltoprazine hydrochloride (DU 28853 hydrochloride) Cat No HY-16687A
Eltoprazine hydrochloride (DU 28853 hydrochloride)is a serenic or antiaggressive agent which as anagonist at the 5-HT1A and 5-HT1B receptors and asan antagonist at the 5-HT2C receptor
Purity 9985Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
EMD 56551Cat No HY-19134
EMD 56551 is a potent and selective 5-HT1A agonist EMD 56551 exerts anxiolyticreceptor
activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eplivanserin (SR-46349) Cat No HY-10792
Eplivanserin is a potent selective and orallyavailable antagonist with an5-HT receptor2
of 58 nM in rat cortical membrane and aIC50
of 114 nMKd
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Eplivanserin (mixture) (SR-46349 (mixture)) Cat No HY-10792A
Eplivanserin mixture (SR-46349 mixture) is aselective inhibitor and aserotonin reuptake
antagonist extracted from5-HT receptor2A
patent WO 2005002578 A1
Purity 9995Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Eptapirone (F 11440) Cat No HY-19946
Eptapirone (F11440) is a potent selective highefficacy 5-HT1A receptor agonist with markedanxiolytic and antidepressant potential
Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
F-15599 (NLX-101) Cat No HY-19863
F-15599 is a highly selective G-protein biased agonist with of 34 nM5-HT1A receptor Ki
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Fabesetron (FK1052 free base) Cat No HY-105201
Fabesetron (FK1052) is an orally active 5-HT3
antagonist with receptor 5-HT receptor4
antagonistic activity Fabesetron (FK1052) can beused in the study for both acute and delayedemesis induced by cancer chemotherapy
Purity 9572Clinical Data No Development ReportedSize 1 mg 5 mg
Facinicline hydrochloride (RG3487 hydrochloride) Cat No HY-108057A
Facinicline hydrochloride (RG3487 hydrochloride)is an orally active partialnicotinic α7 receptoragonist with a of 6 nM for α7 human nAChRKi
Facinicline hydrochloride (RG3487 hydrochloride)improves cognition and sensorimotor gating inrodents
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Fananserin (RP 62203) Cat No HY-103104
Fananserin (RP 62203) is an orally bioavailablepotent and selective 5-hydroxytryptamine2
receptor antagonist with a of 037(5-HT )2 Ki
nM for the rat 5-HT receptor2A
Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
FlesinoxanCat No HY-121653
Flesinoxan is a hypotensive agent and a potenthigh affinity and selective5-hydroxytryptamine1A (5-HT1A) receptoragonist with an value of 24 nM FlesinoxanEC50
also has effective anxiolyticantidepressanteffects
Purity 9907Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 1 g
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Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
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LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
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Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Befiradol hydrochloride (NLX-112 hydrochloride F 13640 hydrochloride) Cat No HY-14785A
Befiradol hydrochloride (NLX-112 hydrochloride) isa selective receptor agonist5-HT1A
Purity 9922Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Bemesetron (MDL 72222) Cat No HY-B1541
Bemesetron (MDL 72222) is a selective 5-HT3
antagonist with an of 033 nMreceptor IC50
Neuroprotective effect
Purity gt990Clinical Data No Development ReportedSize 10 mg
BGC20-761Cat No HY-21995
BGC20-761 is a selecvtive and 5-HT6 dopamine antagonist (human receptor valuesreceptor Ki
5-HT6 (20 nM) 5-HT2A (69 nM) D2 (140 nM)BGC20-761 can enhance long-term memory BGC20-761has potential utility as an antipsychotic agent
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin (AD-5423) Cat No HY-13575
Blonanserin (AD-5423) is a potent and orallyactive ( =0812 nM)5-HT2A Ki
and (dopamine D2enspreceptor Ki
=0142 nM) antagonist
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 100 mg
Blonanserin D5 (AD-5423 D5) Cat No HY-13575S1
Blonanserin D5 (AD-5423 D5) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Blonanserin D8 (AD-5423 D8) Cat No HY-13575S
Blonanserin D8 (AD-5423 D8) is a deuterium labeledBlonanserin Blonanserin is a dopamine
antagonist and an atypicalD 5-HT receptor2 2
antipsychotic
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brexpiprazole (OPC-34712) Cat No HY-15780
Brexpiprazole (OPC-34712) an atypicalantipsychotic drug is a partial agonist of human
and with s of 0125-HT1A dopamine receptor Ki
nM and 03 nM respectively Brexpiprazole is alsoa receptor antagonist with a of 0475-HT2A Ki
nM
Purity 9940Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
Brexpiprazole S-oxide (DM-3411) Cat No HY-133152
Brexpiprazole S-oxide (DM-3411) is a mainmetabolite of Brexpiprazole and is metabolized bycytochrome P450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 5 mg
Brexpiprazole S-oxide D8 (DM-3411 D8) Cat No HY-133152S
Brexpiprazole S-oxide D8 (DM-3411 D8) is adeuterium labeled Brexpiprazole S-oxideBrexpiprazole S-oxide is a main metabolite ofBrexpiprazole and is metabolized by cytochromeP450 3A4 (CYP3A4)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Brilaroxazine (RP5063) Cat No HY-109112
Brilaroxazine (RP5603) is a potent and orallyactive multimodal dopamine (DA)serotonin
modulator(5-HT)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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BRL 54443Cat No HY-13221
BRL 54443 is a potent receptor agonist5-HT1E1F
( values are 11 nM and 07 nM respectively)Ki
displays gt 30-fold selectivity over other 5-HTand dopamine receptors
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
BRL-15572 dihydrochlorideCat No HY-13200
BRL-15572 dihydrochloride is a selectiveantagonist of displays high affinity forh5-HT1D
BRL-15572 dihydrochlorideh5-HT1D receptorscould be useful pharmacological agents tocharacterise mediated responses5-HT1D receptor
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Bromperidol (R-11333) Cat No HY-B0901
Bromperidol is a butyrophenone derivative is apotent and long-acting neuroleptic used as anantipsychotic in the treatment of schizophrenia
Purity 9802Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Buspirone hydrochlorideCat No HY-B1115
Buspirone hydrochloride is an anxiolyticpsychotropic drug is used to treat generalizedanxiety disorder (GAD)
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Cariprazine (RGH-188) Cat No HY-14763
Cariprazine is a novel antipsychotic drugcandidate that exhibits high affinity for the D3
( =0085 nM) and ( =049 nM) receptors andKi D2 Ki
moderate affinity for the receptor5-HT1A
( =26 nM)Ki
Purity 9935Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg
Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A
Cariprazine hydrochloride is a novel antipsychoticdrug candidate that exhibits high affinity for the
( =0085 nM) and ( =049 nM)D3 Ki D2 Ki
receptors and moderate affinity for the 5-HT1A
receptor ( =26 nM)Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 50 mg
CART(62-76)(humanrat)Cat No HY-P1303
CART(62-76)(humanrat) is a neuropeptide (62-76residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
CART(62-76)(humanrat) TFACat No HY-P1303A
CART(62-76)(humanrat) TFA is a neuropeptide(62-76 residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Chlorpromazine D6 hydrochlorideCat No HY-B0407AS
Chlorpromazine D6 hydrochloride is the deuteriumlabeled Chlorpromazine Chlorpromazine is aninhibitor of dopamine receptor 5-HT receptorpotassium channel sodium channel
Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
Chlorpromazine hydrochlorideCat No HY-B0407A
Chlorpromazine hydrochloride is an antagonist ofthe dopamine D2 5HT2A potassium channeland Chlorpromazine binds with D2sodium channeland 5HT2A with s of 363 nM and 83 nMKi
respectively
Purity 9990Clinical Data LaunchedSize 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Cinanserin hydrochloride (SQ 10643) Cat No HY-100943
Cinanserin hydrochloride (SQ 10643) is a potentselective and highly affinity 5-HT receptor2
antagonist with a of 41 nM CinanserinKi
hydrochloride has a much higher binding affinityfor the than for the 5-HT receptor (5-HT2 1 Ki
of 3500 nM)
Purity 9974Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
cis-(Z)-Flupentixol dihydrochloride (cis-(Z)-Flupenthixol dihydrochloride) Cat No HY-15856
cis-(Z)-Flupentixol dihydrochloride is a potentand selective antagonist withDA D1D2 receptor
values of 038 nM and 7 nM for D2 receptor andKi
respectively5-HT2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
cis-Urocanic acid ((Z)-Urocanic acid cis-UCA) Cat No HY-113008A
cis-Urocanic acid is a agonist5-HT2A receptorcis-Urocanic acid binds to with5-HT receptorrelatively high affinity ( =46 nM)Kd
cis-Urocanic acid is an immune modulator thatinduces immunosuppression by binding to the 5-HT2Areceptor
Purity 9992Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg
Cisapride (R 51619 (plusmn)-Cisaprid) Cat No HY-14149
Cisapride(R 51619) is a nonselective 5-HT4receptor agonist it is also a potent hERGpotassium channel inhibitor
Purity 9972Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073
Clocapramine is an antagonist of the D2
5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A
Clocapramine hydrochloride hydrate is anantagonist of the and D2 5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
CP-809101 hydrochlorideCat No HY-15543A
CP-809101 hydrochloride is a potent and selective5-HT2C receptor agonist with pEC50 of996719681 for human 5-HT2C5-HT2B5-HT2Areceptors respectively
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
CyamemazineCat No HY-14264
Cyamemazine is a neuroleptic agent that containsthe phenothiazine chromophore Cyamemazine isoften used as an anxiolytic Cyamemazine is apotent ( of 12 nM) ( = 155-HT3 Ki 5-HT2A Ki
nM) and ( of 75 nM) receptors5-HT2C Ki
antagonist with antipsychotic activity
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Cyclobenzaprine hydrochloride (MK130 hydrochloride) Cat No HY-B0740
Cyclobenzaprine hydrochloride (MK130hydrochloride) is a skeletal muscle relaxant and acentral nervous system (CNS) depressant Target5-HT Receptor 2A Cyclobenzaprine hydrochloride isa skeletal muscle relaxant and a central nervoussystem (CNS) depressant
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Cyproheptadine hydrochlorideCat No HY-B0366A
Cyproheptadine hydrochloride is a 5-HT2A
antagonist with antidepressant andreceptorantiserotonergic effects Cyproheptadinehydrochloride has antiplatelet andthromboprotective activities
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg 1 g
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Cyproheptadine hydrochloride sesquihydrateCat No HY-B1165
Cyproheptadine hydrochloride sesquihydrate is anantihistamine and is an antagonist of serotoninand histamine2
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
Dehydroaripiprazole (OPC-14857 DM-14857) Cat No HY-100665
Dehydroaripiprazole (OPC-14857) is an activemetabolite of Aripiprazole Aripiprazole is anantipsychotic agent and is metabolized by CYP3A4and CYP2D6 forming mainly DehydroaripiprazoleDehydroaripiprazole has with antipsychoticactivity equivalent to Aripiprazole
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Deramciclane (EGIS-3886) Cat No HY-101630
Deramciclane has a high affinity for and5-HT2A
receptors it acts as an antagonist at5-HT2C
both receptor subtypes and has inverse agonistproperties at the 5-HT receptors without direct2C
stimulatory agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Dihydroergotamine mesylateCat No HY-B0670A
Dihydroergotamine mesylate is an ergot alkaloidused to treat migraines
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Dolasetron (MDL-73147) Cat No HY-B0750
Dolasetron(MDL-73147) is a serotonin 5-HT3receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
Dolasetron Mesylate (MDL-73147EF) Cat No HY-B0750A
Dolasetron Mesylate (MDL-73147EF) is a serotonin5-HT3 receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) Cat No HY-B0750B
Dolasetron Mesylate hydrate (MDL-73147EF hydrate)is a serotonin 5-HT3 receptor antagonist used totreat nausea and vomiting following chemotherapy
Purity gt990Clinical Data LaunchedSize 100 mg 200 mg
DonitriptanCat No HY-106157
Donitriptan is a potent high efficacy agonist ats with s of 94 and 935-HT receptor1B1D pKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eletriptan hydrobromide (Eletriptan HBr) Cat No HY-A0010
Eletriptan HBr is a selective 5-HT1B and 5-HT1Dreceptor agonist with Ki of 092 nM and 314 nMrespectively
Purity 9513Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Eltoprazine (DU 28853) Cat No HY-16687
Eltoprazine(DU28853) is a serenic orantiaggressive agent which as an agonist at the5-HT1A and 5-HT1B receptors and as an antagonistat the 5-HT2C receptor
Purity gt950Clinical Data Phase 2Size 1 mg 5 mg
wwwMedChemExpresscom 11
Eltoprazine hydrochloride (DU 28853 hydrochloride) Cat No HY-16687A
Eltoprazine hydrochloride (DU 28853 hydrochloride)is a serenic or antiaggressive agent which as anagonist at the 5-HT1A and 5-HT1B receptors and asan antagonist at the 5-HT2C receptor
Purity 9985Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
EMD 56551Cat No HY-19134
EMD 56551 is a potent and selective 5-HT1A agonist EMD 56551 exerts anxiolyticreceptor
activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eplivanserin (SR-46349) Cat No HY-10792
Eplivanserin is a potent selective and orallyavailable antagonist with an5-HT receptor2
of 58 nM in rat cortical membrane and aIC50
of 114 nMKd
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Eplivanserin (mixture) (SR-46349 (mixture)) Cat No HY-10792A
Eplivanserin mixture (SR-46349 mixture) is aselective inhibitor and aserotonin reuptake
antagonist extracted from5-HT receptor2A
patent WO 2005002578 A1
Purity 9995Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Eptapirone (F 11440) Cat No HY-19946
Eptapirone (F11440) is a potent selective highefficacy 5-HT1A receptor agonist with markedanxiolytic and antidepressant potential
Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
F-15599 (NLX-101) Cat No HY-19863
F-15599 is a highly selective G-protein biased agonist with of 34 nM5-HT1A receptor Ki
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Fabesetron (FK1052 free base) Cat No HY-105201
Fabesetron (FK1052) is an orally active 5-HT3
antagonist with receptor 5-HT receptor4
antagonistic activity Fabesetron (FK1052) can beused in the study for both acute and delayedemesis induced by cancer chemotherapy
Purity 9572Clinical Data No Development ReportedSize 1 mg 5 mg
Facinicline hydrochloride (RG3487 hydrochloride) Cat No HY-108057A
Facinicline hydrochloride (RG3487 hydrochloride)is an orally active partialnicotinic α7 receptoragonist with a of 6 nM for α7 human nAChRKi
Facinicline hydrochloride (RG3487 hydrochloride)improves cognition and sensorimotor gating inrodents
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Fananserin (RP 62203) Cat No HY-103104
Fananserin (RP 62203) is an orally bioavailablepotent and selective 5-hydroxytryptamine2
receptor antagonist with a of 037(5-HT )2 Ki
nM for the rat 5-HT receptor2A
Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
FlesinoxanCat No HY-121653
Flesinoxan is a hypotensive agent and a potenthigh affinity and selective5-hydroxytryptamine1A (5-HT1A) receptoragonist with an value of 24 nM FlesinoxanEC50
also has effective anxiolyticantidepressanteffects
Purity 9907Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 1 g
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Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
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Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
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LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
18 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
22 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
BRL 54443Cat No HY-13221
BRL 54443 is a potent receptor agonist5-HT1E1F
( values are 11 nM and 07 nM respectively)Ki
displays gt 30-fold selectivity over other 5-HTand dopamine receptors
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
BRL-15572 dihydrochlorideCat No HY-13200
BRL-15572 dihydrochloride is a selectiveantagonist of displays high affinity forh5-HT1D
BRL-15572 dihydrochlorideh5-HT1D receptorscould be useful pharmacological agents tocharacterise mediated responses5-HT1D receptor
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Bromperidol (R-11333) Cat No HY-B0901
Bromperidol is a butyrophenone derivative is apotent and long-acting neuroleptic used as anantipsychotic in the treatment of schizophrenia
Purity 9802Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Buspirone hydrochlorideCat No HY-B1115
Buspirone hydrochloride is an anxiolyticpsychotropic drug is used to treat generalizedanxiety disorder (GAD)
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Cariprazine (RGH-188) Cat No HY-14763
Cariprazine is a novel antipsychotic drugcandidate that exhibits high affinity for the D3
( =0085 nM) and ( =049 nM) receptors andKi D2 Ki
moderate affinity for the receptor5-HT1A
( =26 nM)Ki
Purity 9935Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg
Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A
Cariprazine hydrochloride is a novel antipsychoticdrug candidate that exhibits high affinity for the
( =0085 nM) and ( =049 nM)D3 Ki D2 Ki
receptors and moderate affinity for the 5-HT1A
receptor ( =26 nM)Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 25 mg 50 mg
CART(62-76)(humanrat)Cat No HY-P1303
CART(62-76)(humanrat) is a neuropeptide (62-76residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
CART(62-76)(humanrat) TFACat No HY-P1303A
CART(62-76)(humanrat) TFA is a neuropeptide(62-76 residues of the CART peptide) withneurotransmitter-like effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Chlorpromazine D6 hydrochlorideCat No HY-B0407AS
Chlorpromazine D6 hydrochloride is the deuteriumlabeled Chlorpromazine Chlorpromazine is aninhibitor of dopamine receptor 5-HT receptorpotassium channel sodium channel
Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
Chlorpromazine hydrochlorideCat No HY-B0407A
Chlorpromazine hydrochloride is an antagonist ofthe dopamine D2 5HT2A potassium channeland Chlorpromazine binds with D2sodium channeland 5HT2A with s of 363 nM and 83 nMKi
respectively
Purity 9990Clinical Data LaunchedSize 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Cinanserin hydrochloride (SQ 10643) Cat No HY-100943
Cinanserin hydrochloride (SQ 10643) is a potentselective and highly affinity 5-HT receptor2
antagonist with a of 41 nM CinanserinKi
hydrochloride has a much higher binding affinityfor the than for the 5-HT receptor (5-HT2 1 Ki
of 3500 nM)
Purity 9974Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
cis-(Z)-Flupentixol dihydrochloride (cis-(Z)-Flupenthixol dihydrochloride) Cat No HY-15856
cis-(Z)-Flupentixol dihydrochloride is a potentand selective antagonist withDA D1D2 receptor
values of 038 nM and 7 nM for D2 receptor andKi
respectively5-HT2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
cis-Urocanic acid ((Z)-Urocanic acid cis-UCA) Cat No HY-113008A
cis-Urocanic acid is a agonist5-HT2A receptorcis-Urocanic acid binds to with5-HT receptorrelatively high affinity ( =46 nM)Kd
cis-Urocanic acid is an immune modulator thatinduces immunosuppression by binding to the 5-HT2Areceptor
Purity 9992Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg
Cisapride (R 51619 (plusmn)-Cisaprid) Cat No HY-14149
Cisapride(R 51619) is a nonselective 5-HT4receptor agonist it is also a potent hERGpotassium channel inhibitor
Purity 9972Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073
Clocapramine is an antagonist of the D2
5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A
Clocapramine hydrochloride hydrate is anantagonist of the and D2 5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
CP-809101 hydrochlorideCat No HY-15543A
CP-809101 hydrochloride is a potent and selective5-HT2C receptor agonist with pEC50 of996719681 for human 5-HT2C5-HT2B5-HT2Areceptors respectively
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
CyamemazineCat No HY-14264
Cyamemazine is a neuroleptic agent that containsthe phenothiazine chromophore Cyamemazine isoften used as an anxiolytic Cyamemazine is apotent ( of 12 nM) ( = 155-HT3 Ki 5-HT2A Ki
nM) and ( of 75 nM) receptors5-HT2C Ki
antagonist with antipsychotic activity
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Cyclobenzaprine hydrochloride (MK130 hydrochloride) Cat No HY-B0740
Cyclobenzaprine hydrochloride (MK130hydrochloride) is a skeletal muscle relaxant and acentral nervous system (CNS) depressant Target5-HT Receptor 2A Cyclobenzaprine hydrochloride isa skeletal muscle relaxant and a central nervoussystem (CNS) depressant
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Cyproheptadine hydrochlorideCat No HY-B0366A
Cyproheptadine hydrochloride is a 5-HT2A
antagonist with antidepressant andreceptorantiserotonergic effects Cyproheptadinehydrochloride has antiplatelet andthromboprotective activities
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg 1 g
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Cyproheptadine hydrochloride sesquihydrateCat No HY-B1165
Cyproheptadine hydrochloride sesquihydrate is anantihistamine and is an antagonist of serotoninand histamine2
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
Dehydroaripiprazole (OPC-14857 DM-14857) Cat No HY-100665
Dehydroaripiprazole (OPC-14857) is an activemetabolite of Aripiprazole Aripiprazole is anantipsychotic agent and is metabolized by CYP3A4and CYP2D6 forming mainly DehydroaripiprazoleDehydroaripiprazole has with antipsychoticactivity equivalent to Aripiprazole
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Deramciclane (EGIS-3886) Cat No HY-101630
Deramciclane has a high affinity for and5-HT2A
receptors it acts as an antagonist at5-HT2C
both receptor subtypes and has inverse agonistproperties at the 5-HT receptors without direct2C
stimulatory agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Dihydroergotamine mesylateCat No HY-B0670A
Dihydroergotamine mesylate is an ergot alkaloidused to treat migraines
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Dolasetron (MDL-73147) Cat No HY-B0750
Dolasetron(MDL-73147) is a serotonin 5-HT3receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
Dolasetron Mesylate (MDL-73147EF) Cat No HY-B0750A
Dolasetron Mesylate (MDL-73147EF) is a serotonin5-HT3 receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) Cat No HY-B0750B
Dolasetron Mesylate hydrate (MDL-73147EF hydrate)is a serotonin 5-HT3 receptor antagonist used totreat nausea and vomiting following chemotherapy
Purity gt990Clinical Data LaunchedSize 100 mg 200 mg
DonitriptanCat No HY-106157
Donitriptan is a potent high efficacy agonist ats with s of 94 and 935-HT receptor1B1D pKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eletriptan hydrobromide (Eletriptan HBr) Cat No HY-A0010
Eletriptan HBr is a selective 5-HT1B and 5-HT1Dreceptor agonist with Ki of 092 nM and 314 nMrespectively
Purity 9513Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Eltoprazine (DU 28853) Cat No HY-16687
Eltoprazine(DU28853) is a serenic orantiaggressive agent which as an agonist at the5-HT1A and 5-HT1B receptors and as an antagonistat the 5-HT2C receptor
Purity gt950Clinical Data Phase 2Size 1 mg 5 mg
wwwMedChemExpresscom 11
Eltoprazine hydrochloride (DU 28853 hydrochloride) Cat No HY-16687A
Eltoprazine hydrochloride (DU 28853 hydrochloride)is a serenic or antiaggressive agent which as anagonist at the 5-HT1A and 5-HT1B receptors and asan antagonist at the 5-HT2C receptor
Purity 9985Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
EMD 56551Cat No HY-19134
EMD 56551 is a potent and selective 5-HT1A agonist EMD 56551 exerts anxiolyticreceptor
activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eplivanserin (SR-46349) Cat No HY-10792
Eplivanserin is a potent selective and orallyavailable antagonist with an5-HT receptor2
of 58 nM in rat cortical membrane and aIC50
of 114 nMKd
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Eplivanserin (mixture) (SR-46349 (mixture)) Cat No HY-10792A
Eplivanserin mixture (SR-46349 mixture) is aselective inhibitor and aserotonin reuptake
antagonist extracted from5-HT receptor2A
patent WO 2005002578 A1
Purity 9995Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Eptapirone (F 11440) Cat No HY-19946
Eptapirone (F11440) is a potent selective highefficacy 5-HT1A receptor agonist with markedanxiolytic and antidepressant potential
Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
F-15599 (NLX-101) Cat No HY-19863
F-15599 is a highly selective G-protein biased agonist with of 34 nM5-HT1A receptor Ki
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Fabesetron (FK1052 free base) Cat No HY-105201
Fabesetron (FK1052) is an orally active 5-HT3
antagonist with receptor 5-HT receptor4
antagonistic activity Fabesetron (FK1052) can beused in the study for both acute and delayedemesis induced by cancer chemotherapy
Purity 9572Clinical Data No Development ReportedSize 1 mg 5 mg
Facinicline hydrochloride (RG3487 hydrochloride) Cat No HY-108057A
Facinicline hydrochloride (RG3487 hydrochloride)is an orally active partialnicotinic α7 receptoragonist with a of 6 nM for α7 human nAChRKi
Facinicline hydrochloride (RG3487 hydrochloride)improves cognition and sensorimotor gating inrodents
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Fananserin (RP 62203) Cat No HY-103104
Fananserin (RP 62203) is an orally bioavailablepotent and selective 5-hydroxytryptamine2
receptor antagonist with a of 037(5-HT )2 Ki
nM for the rat 5-HT receptor2A
Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
FlesinoxanCat No HY-121653
Flesinoxan is a hypotensive agent and a potenthigh affinity and selective5-hydroxytryptamine1A (5-HT1A) receptoragonist with an value of 24 nM FlesinoxanEC50
also has effective anxiolyticantidepressanteffects
Purity 9907Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 1 g
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Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
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Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
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LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
18 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
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Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Cinanserin hydrochloride (SQ 10643) Cat No HY-100943
Cinanserin hydrochloride (SQ 10643) is a potentselective and highly affinity 5-HT receptor2
antagonist with a of 41 nM CinanserinKi
hydrochloride has a much higher binding affinityfor the than for the 5-HT receptor (5-HT2 1 Ki
of 3500 nM)
Purity 9974Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
cis-(Z)-Flupentixol dihydrochloride (cis-(Z)-Flupenthixol dihydrochloride) Cat No HY-15856
cis-(Z)-Flupentixol dihydrochloride is a potentand selective antagonist withDA D1D2 receptor
values of 038 nM and 7 nM for D2 receptor andKi
respectively5-HT2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
cis-Urocanic acid ((Z)-Urocanic acid cis-UCA) Cat No HY-113008A
cis-Urocanic acid is a agonist5-HT2A receptorcis-Urocanic acid binds to with5-HT receptorrelatively high affinity ( =46 nM)Kd
cis-Urocanic acid is an immune modulator thatinduces immunosuppression by binding to the 5-HT2Areceptor
Purity 9992Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg
Cisapride (R 51619 (plusmn)-Cisaprid) Cat No HY-14149
Cisapride(R 51619) is a nonselective 5-HT4receptor agonist it is also a potent hERGpotassium channel inhibitor
Purity 9972Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073
Clocapramine is an antagonist of the D2
5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A
Clocapramine hydrochloride hydrate is anantagonist of the and D2 5-HT receptors2A
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
CP-809101 hydrochlorideCat No HY-15543A
CP-809101 hydrochloride is a potent and selective5-HT2C receptor agonist with pEC50 of996719681 for human 5-HT2C5-HT2B5-HT2Areceptors respectively
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
CyamemazineCat No HY-14264
Cyamemazine is a neuroleptic agent that containsthe phenothiazine chromophore Cyamemazine isoften used as an anxiolytic Cyamemazine is apotent ( of 12 nM) ( = 155-HT3 Ki 5-HT2A Ki
nM) and ( of 75 nM) receptors5-HT2C Ki
antagonist with antipsychotic activity
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Cyclobenzaprine hydrochloride (MK130 hydrochloride) Cat No HY-B0740
Cyclobenzaprine hydrochloride (MK130hydrochloride) is a skeletal muscle relaxant and acentral nervous system (CNS) depressant Target5-HT Receptor 2A Cyclobenzaprine hydrochloride isa skeletal muscle relaxant and a central nervoussystem (CNS) depressant
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Cyproheptadine hydrochlorideCat No HY-B0366A
Cyproheptadine hydrochloride is a 5-HT2A
antagonist with antidepressant andreceptorantiserotonergic effects Cyproheptadinehydrochloride has antiplatelet andthromboprotective activities
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg 1 g
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Cyproheptadine hydrochloride sesquihydrateCat No HY-B1165
Cyproheptadine hydrochloride sesquihydrate is anantihistamine and is an antagonist of serotoninand histamine2
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
Dehydroaripiprazole (OPC-14857 DM-14857) Cat No HY-100665
Dehydroaripiprazole (OPC-14857) is an activemetabolite of Aripiprazole Aripiprazole is anantipsychotic agent and is metabolized by CYP3A4and CYP2D6 forming mainly DehydroaripiprazoleDehydroaripiprazole has with antipsychoticactivity equivalent to Aripiprazole
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Deramciclane (EGIS-3886) Cat No HY-101630
Deramciclane has a high affinity for and5-HT2A
receptors it acts as an antagonist at5-HT2C
both receptor subtypes and has inverse agonistproperties at the 5-HT receptors without direct2C
stimulatory agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Dihydroergotamine mesylateCat No HY-B0670A
Dihydroergotamine mesylate is an ergot alkaloidused to treat migraines
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Dolasetron (MDL-73147) Cat No HY-B0750
Dolasetron(MDL-73147) is a serotonin 5-HT3receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
Dolasetron Mesylate (MDL-73147EF) Cat No HY-B0750A
Dolasetron Mesylate (MDL-73147EF) is a serotonin5-HT3 receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) Cat No HY-B0750B
Dolasetron Mesylate hydrate (MDL-73147EF hydrate)is a serotonin 5-HT3 receptor antagonist used totreat nausea and vomiting following chemotherapy
Purity gt990Clinical Data LaunchedSize 100 mg 200 mg
DonitriptanCat No HY-106157
Donitriptan is a potent high efficacy agonist ats with s of 94 and 935-HT receptor1B1D pKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eletriptan hydrobromide (Eletriptan HBr) Cat No HY-A0010
Eletriptan HBr is a selective 5-HT1B and 5-HT1Dreceptor agonist with Ki of 092 nM and 314 nMrespectively
Purity 9513Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Eltoprazine (DU 28853) Cat No HY-16687
Eltoprazine(DU28853) is a serenic orantiaggressive agent which as an agonist at the5-HT1A and 5-HT1B receptors and as an antagonistat the 5-HT2C receptor
Purity gt950Clinical Data Phase 2Size 1 mg 5 mg
wwwMedChemExpresscom 11
Eltoprazine hydrochloride (DU 28853 hydrochloride) Cat No HY-16687A
Eltoprazine hydrochloride (DU 28853 hydrochloride)is a serenic or antiaggressive agent which as anagonist at the 5-HT1A and 5-HT1B receptors and asan antagonist at the 5-HT2C receptor
Purity 9985Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
EMD 56551Cat No HY-19134
EMD 56551 is a potent and selective 5-HT1A agonist EMD 56551 exerts anxiolyticreceptor
activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eplivanserin (SR-46349) Cat No HY-10792
Eplivanserin is a potent selective and orallyavailable antagonist with an5-HT receptor2
of 58 nM in rat cortical membrane and aIC50
of 114 nMKd
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Eplivanserin (mixture) (SR-46349 (mixture)) Cat No HY-10792A
Eplivanserin mixture (SR-46349 mixture) is aselective inhibitor and aserotonin reuptake
antagonist extracted from5-HT receptor2A
patent WO 2005002578 A1
Purity 9995Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Eptapirone (F 11440) Cat No HY-19946
Eptapirone (F11440) is a potent selective highefficacy 5-HT1A receptor agonist with markedanxiolytic and antidepressant potential
Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
F-15599 (NLX-101) Cat No HY-19863
F-15599 is a highly selective G-protein biased agonist with of 34 nM5-HT1A receptor Ki
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Fabesetron (FK1052 free base) Cat No HY-105201
Fabesetron (FK1052) is an orally active 5-HT3
antagonist with receptor 5-HT receptor4
antagonistic activity Fabesetron (FK1052) can beused in the study for both acute and delayedemesis induced by cancer chemotherapy
Purity 9572Clinical Data No Development ReportedSize 1 mg 5 mg
Facinicline hydrochloride (RG3487 hydrochloride) Cat No HY-108057A
Facinicline hydrochloride (RG3487 hydrochloride)is an orally active partialnicotinic α7 receptoragonist with a of 6 nM for α7 human nAChRKi
Facinicline hydrochloride (RG3487 hydrochloride)improves cognition and sensorimotor gating inrodents
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Fananserin (RP 62203) Cat No HY-103104
Fananserin (RP 62203) is an orally bioavailablepotent and selective 5-hydroxytryptamine2
receptor antagonist with a of 037(5-HT )2 Ki
nM for the rat 5-HT receptor2A
Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
FlesinoxanCat No HY-121653
Flesinoxan is a hypotensive agent and a potenthigh affinity and selective5-hydroxytryptamine1A (5-HT1A) receptoragonist with an value of 24 nM FlesinoxanEC50
also has effective anxiolyticantidepressanteffects
Purity 9907Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 1 g
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
18 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Cyproheptadine hydrochloride sesquihydrateCat No HY-B1165
Cyproheptadine hydrochloride sesquihydrate is anantihistamine and is an antagonist of serotoninand histamine2
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
Dehydroaripiprazole (OPC-14857 DM-14857) Cat No HY-100665
Dehydroaripiprazole (OPC-14857) is an activemetabolite of Aripiprazole Aripiprazole is anantipsychotic agent and is metabolized by CYP3A4and CYP2D6 forming mainly DehydroaripiprazoleDehydroaripiprazole has with antipsychoticactivity equivalent to Aripiprazole
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Deramciclane (EGIS-3886) Cat No HY-101630
Deramciclane has a high affinity for and5-HT2A
receptors it acts as an antagonist at5-HT2C
both receptor subtypes and has inverse agonistproperties at the 5-HT receptors without direct2C
stimulatory agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Dihydroergotamine mesylateCat No HY-B0670A
Dihydroergotamine mesylate is an ergot alkaloidused to treat migraines
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Dolasetron (MDL-73147) Cat No HY-B0750
Dolasetron(MDL-73147) is a serotonin 5-HT3receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
Dolasetron Mesylate (MDL-73147EF) Cat No HY-B0750A
Dolasetron Mesylate (MDL-73147EF) is a serotonin5-HT3 receptor antagonist used to treat nausea andvomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) Cat No HY-B0750B
Dolasetron Mesylate hydrate (MDL-73147EF hydrate)is a serotonin 5-HT3 receptor antagonist used totreat nausea and vomiting following chemotherapy
Purity gt990Clinical Data LaunchedSize 100 mg 200 mg
DonitriptanCat No HY-106157
Donitriptan is a potent high efficacy agonist ats with s of 94 and 935-HT receptor1B1D pKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eletriptan hydrobromide (Eletriptan HBr) Cat No HY-A0010
Eletriptan HBr is a selective 5-HT1B and 5-HT1Dreceptor agonist with Ki of 092 nM and 314 nMrespectively
Purity 9513Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Eltoprazine (DU 28853) Cat No HY-16687
Eltoprazine(DU28853) is a serenic orantiaggressive agent which as an agonist at the5-HT1A and 5-HT1B receptors and as an antagonistat the 5-HT2C receptor
Purity gt950Clinical Data Phase 2Size 1 mg 5 mg
wwwMedChemExpresscom 11
Eltoprazine hydrochloride (DU 28853 hydrochloride) Cat No HY-16687A
Eltoprazine hydrochloride (DU 28853 hydrochloride)is a serenic or antiaggressive agent which as anagonist at the 5-HT1A and 5-HT1B receptors and asan antagonist at the 5-HT2C receptor
Purity 9985Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
EMD 56551Cat No HY-19134
EMD 56551 is a potent and selective 5-HT1A agonist EMD 56551 exerts anxiolyticreceptor
activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eplivanserin (SR-46349) Cat No HY-10792
Eplivanserin is a potent selective and orallyavailable antagonist with an5-HT receptor2
of 58 nM in rat cortical membrane and aIC50
of 114 nMKd
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Eplivanserin (mixture) (SR-46349 (mixture)) Cat No HY-10792A
Eplivanserin mixture (SR-46349 mixture) is aselective inhibitor and aserotonin reuptake
antagonist extracted from5-HT receptor2A
patent WO 2005002578 A1
Purity 9995Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Eptapirone (F 11440) Cat No HY-19946
Eptapirone (F11440) is a potent selective highefficacy 5-HT1A receptor agonist with markedanxiolytic and antidepressant potential
Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
F-15599 (NLX-101) Cat No HY-19863
F-15599 is a highly selective G-protein biased agonist with of 34 nM5-HT1A receptor Ki
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Fabesetron (FK1052 free base) Cat No HY-105201
Fabesetron (FK1052) is an orally active 5-HT3
antagonist with receptor 5-HT receptor4
antagonistic activity Fabesetron (FK1052) can beused in the study for both acute and delayedemesis induced by cancer chemotherapy
Purity 9572Clinical Data No Development ReportedSize 1 mg 5 mg
Facinicline hydrochloride (RG3487 hydrochloride) Cat No HY-108057A
Facinicline hydrochloride (RG3487 hydrochloride)is an orally active partialnicotinic α7 receptoragonist with a of 6 nM for α7 human nAChRKi
Facinicline hydrochloride (RG3487 hydrochloride)improves cognition and sensorimotor gating inrodents
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Fananserin (RP 62203) Cat No HY-103104
Fananserin (RP 62203) is an orally bioavailablepotent and selective 5-hydroxytryptamine2
receptor antagonist with a of 037(5-HT )2 Ki
nM for the rat 5-HT receptor2A
Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
FlesinoxanCat No HY-121653
Flesinoxan is a hypotensive agent and a potenthigh affinity and selective5-hydroxytryptamine1A (5-HT1A) receptoragonist with an value of 24 nM FlesinoxanEC50
also has effective anxiolyticantidepressanteffects
Purity 9907Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 1 g
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
18 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
22 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
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Eltoprazine hydrochloride (DU 28853 hydrochloride) Cat No HY-16687A
Eltoprazine hydrochloride (DU 28853 hydrochloride)is a serenic or antiaggressive agent which as anagonist at the 5-HT1A and 5-HT1B receptors and asan antagonist at the 5-HT2C receptor
Purity 9985Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
EMD 56551Cat No HY-19134
EMD 56551 is a potent and selective 5-HT1A agonist EMD 56551 exerts anxiolyticreceptor
activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Eplivanserin (SR-46349) Cat No HY-10792
Eplivanserin is a potent selective and orallyavailable antagonist with an5-HT receptor2
of 58 nM in rat cortical membrane and aIC50
of 114 nMKd
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Eplivanserin (mixture) (SR-46349 (mixture)) Cat No HY-10792A
Eplivanserin mixture (SR-46349 mixture) is aselective inhibitor and aserotonin reuptake
antagonist extracted from5-HT receptor2A
patent WO 2005002578 A1
Purity 9995Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Eptapirone (F 11440) Cat No HY-19946
Eptapirone (F11440) is a potent selective highefficacy 5-HT1A receptor agonist with markedanxiolytic and antidepressant potential
Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
F-15599 (NLX-101) Cat No HY-19863
F-15599 is a highly selective G-protein biased agonist with of 34 nM5-HT1A receptor Ki
Purity 9961Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Fabesetron (FK1052 free base) Cat No HY-105201
Fabesetron (FK1052) is an orally active 5-HT3
antagonist with receptor 5-HT receptor4
antagonistic activity Fabesetron (FK1052) can beused in the study for both acute and delayedemesis induced by cancer chemotherapy
Purity 9572Clinical Data No Development ReportedSize 1 mg 5 mg
Facinicline hydrochloride (RG3487 hydrochloride) Cat No HY-108057A
Facinicline hydrochloride (RG3487 hydrochloride)is an orally active partialnicotinic α7 receptoragonist with a of 6 nM for α7 human nAChRKi
Facinicline hydrochloride (RG3487 hydrochloride)improves cognition and sensorimotor gating inrodents
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Fananserin (RP 62203) Cat No HY-103104
Fananserin (RP 62203) is an orally bioavailablepotent and selective 5-hydroxytryptamine2
receptor antagonist with a of 037(5-HT )2 Ki
nM for the rat 5-HT receptor2A
Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
FlesinoxanCat No HY-121653
Flesinoxan is a hypotensive agent and a potenthigh affinity and selective5-hydroxytryptamine1A (5-HT1A) receptoragonist with an value of 24 nM FlesinoxanEC50
also has effective anxiolyticantidepressanteffects
Purity 9907Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 1 g
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Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
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LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
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Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
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Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
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PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Flibanserin (BIMT-17 BIMT-17BS) Cat No HY-A0095
Flibanserin (BIMT-17) is a full agonist of theserotonin ( =1 nM) and an5-HT1A receptor Ki
antagonist of (49 nM)5-HT2A
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Flibanserin D4 (BIMT-17 D4 BIMT-17BS D4) Cat No HY-A0095S
Flibanserin D4 is a deuterium labeled Flibanserin(BIMT-17) Flibanserin is a full agonist of theserotonin 5-HT1A receptor (K =1 nM) and ani
antagonist of 5-HT2A (49 nM)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
FlopropioneCat No HY-100562
Flopropione is a antagonist and5-HT receptoralso a catechol-o-methyltransferase (COMT)inhibitor Flopropione also as an antispasmodicagent
Purity 9837Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
FlumexadolCat No HY-133024
Flumexadol is an orally active non-narcoticanalgesic Flumexadol is a selective and affinity
agonist with a of 25 nM for5-HT receptor2C Ki
the (+)-enantiomer of Flumexadol and is 40-foldselective over the 5-HT receptor2A
Purity 9850Clinical Data No Development ReportedSize 5 mg 10 mg
Frovatriptan succinate ((R)-Frovatriptan succinate SB 209509
succinate VML 251 succinate) Cat No HY-B1658B
Frovatriptan succinate ((R)-Frovatriptansuccinate) is a potent high affinity selectiveand orally active ( of 82) and5-HT1B pK50
agonist5-HT receptor1D
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate
hydrate SB 209509 succinate hydrate hellip) Cat No HY-B1658A
Frovatriptan succinate hydrate ((R)-Frovatriptansuccinate hydrate) is a potent high affinityselective and orally active ( of5-HT1B pK50
82) and agonist5-HT receptor1D
Purity gt990Clinical Data LaunchedSize 1 mg
Gamma-Mangostin (γ-Mangostin) Cat No HY-N1957
Gamma-Mangostin is a novel competitive5-hydroxytryptamine 2A (5-HT2A) receptorsantagonist purified from the fruit hull of themedicinal plant Garcinia mangostana
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Geissoschizine methyl etherCat No HY-N2411
Geissoschizine methyl ether a major indolealkaloid found in hook is a major activeUncariacomponent of Yokukansan with psychotropic effectsGeissoschizine methyl ether is potent 5-HT1A
agonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 113808Cat No HY-103152
GR 113808 is a potent and highly selective antagonist ( = 88) GR5-HT receptor4 pKb
113808 shows 300-fold selectivity over 5-HT 1A
5-HT 5-HT 5-HT and 5-HT receptors1B 2A 2C 3
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
GR 125743Cat No HY-121392
GR 125743 is a selective receptor5-HT1B1D
antagonist with pK s of 885 and 831 fori
wild-type h5-HT and wild-type h5-HT 1B 1D
respectively GR 125743 is used for the researchof Parkinsons disease and cardiovasculardiseases
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
18 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Granisetron (BRL 43694) Cat No HY-B0071
Granisetron (BRL 43694) is a serotonin 5-HT3receptor antagonist used as an antiemetic to treatnausea and vomiting following chemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Granisetron Hydrochloride (BRL 43694A) Cat No HY-B0071A
Granisetron (Hydrochloride) (BRL 43694A) is aserotonin 5-HT3 receptor antagonist used as anantiemetic to treat nausea and vomiting followingchemotherapy
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
GSK163090Cat No HY-14348
GSK163090 is a potent selective and orally active antagonist with 5-HT receptor1A1B1D pKi
values of 948597 respectively GSK163090inhibits the functional activity of serotoninreuptake transporter (SerT) with a value ofpKi
61
Purity 9995Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GTS-21 dihydrochloride (DMXB-A DMBX-anabaseine) Cat No HY-14564A
GTS-21 dihydrochloride is a selective alpha7nicotinic acetylcholine receptor (α7-nAChR)agonist with antiinflammatory andcognitionenhancing activities
Purity 9978Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Harmine (Telepathine) Cat No HY-N0737A
Harmine is a natural dual-specificity tyrosinephosphorylation-regulated kinase ( ) inhibitorDYRKwith anticancer and anti-inflammatory activitiesHarmine has a high affinity of 5-HT serotonin2A
with an of 397 nMreceptor Ki
Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Harmine hydrochloride (Telepathine hydrochloride) Cat No HY-N0737
Harmine Hydrochloride (Telepathine Hydrochloride)is a natural inhibitor with anticancer andDYRKanti-inflammatory activities Harmine has a highaffinity of with an5-HT serotonin receptor2A
of 397 nMKi
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Hydroxy ziprasidoneCat No HY-100649
Hydroxy ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) Cat No HY-14338A
Idalopirdine Hydrochloride (Lu AE58054Hydrochloride) is a potent and selective 5-HT6
antagonist with a of 083 nMreceptor Ki
Purity 9983Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg
Iferanserin (S-MPEC) Cat No HY-118557
Iferanserin (S-MPEC) is a selective 5-HT ( ) antagonist with anreceptor serotonin receptor
affinity for Iferanserin has5-HT receptor2A
the potential for internal hemorrhoid diseasetreatment
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iloperidone (HP 873) Cat No HY-17410
Iloperidone (HP 873) is a receptorD 5-HT2 2
antagonist Iloperidone is an atypicalantipsychotic for the schizophrenia symptoms
Purity 9964Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
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LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
18 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
22 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
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Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A
Iloperidone hydrochloride (HP 873 hydrochloride)is a receptor antagonist IloperidoneD 5-HT2 2
hydrochloride is an atypical antipsychotic for theschizophrenia symptoms
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Intepirdine (SB-742457 GSK-742457 RVT-101) Cat No HY-14339
Intepirdine (SB742457) is a highly selective 5-HT6receptor antagonist with pKi of 963 exhibitsgt100-fold selectivity over other receptors
Purity 9892Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
IprindoleCat No HY-12392
Iprindole a tricyclic indole antidepressant is aweak inhibitor of the uptake of noradrenaline and5-HTltbrgt
Purity 9802Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Ipsapirone (TVX Q 7821 free base) Cat No HY-19686
Ipsapirone (TVX Q 7821) is an anxiolytic compoundand a receptor partial agonist5-HT1A
Ipsapirone (TVX Q 7821) also exhibits 5-HT1A
receptor antagonistic effect and only at highdoses it can also produce an inhibitory effect on5-HT and the α -adrenergic function2 1
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Irindalone (Lu 21-098) Cat No HY-101632
Irindalone is a novel serotonin 5-HT2
antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isamoltane hemifumarateCat No HY-19578B
Isamoltane hemifumarate is a selective antagonistof with an of 39 nM for5-HT receptor1B IC50
inhibits the binding of [ I]ICYP to 5-HT1251B
recognition sites in rat brain membranesIsamoltane hemifumarate is also a β-adrenoceptorligand with an of 84 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Isocorynoxeine (7-Isocorynoxeine) Cat No HY-N0775
Isocorynoxeine an isorhynchophylline-relatedalkaloid exhibits a dose-dependent inhibition of
receptor-mediated current response with5-HT2A
an of 724 μMIC50
Purity 9997Clinical Data No Development ReportedSize 5 mg 10 mg
IsopteropodineCat No HY-N4157
Isopteropodine is heteroyohimbine-type oxindolealkaloid components of Uncaria tomentosa(Willd) DC Isopteropodine acts as positivemodulators of and muscarinic M1 5-HT2receptors
Purity gt98Clinical Data No Development ReportedSize 5 mg
JatrorrhizineCat No HY-N0749
Jatrorrhizine is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Jatrorrhizine chlorideCat No HY-N0740
Jatrorrhizine chloride is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
wwwMedChemExpresscom 15
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
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LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
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Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
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Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
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Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Jatrorrhizine hydroxideCat No HY-N0749A
Jatrorrhizineensphydroxide is an alkaloid isolatedfrom with neuroprotectiveCoptis chinensisantimicrobial antiplasmodial and antioxidantactivities
Purity 9802Clinical Data No Development ReportedSize 5 mg 10 mg
JNJ-18038683Cat No HY-19889
JNJ-18038683 is a 5-Hydroxytryptamine Type 7( ) receptor antagonist with of 8195-HT7 pK si820 for rat and human 5-HT in HEK293 cells7
respectively
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Ketanserin (R41468) Cat No HY-10562
Ketanserin is a selective 5-HT2 receptorantagonist Ketanserin also blocks hERG current( ) in a concentration-dependent mannerIhERG
( =011 μM)IC50
Purity 9857Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Ketanserin tartrate (R41468 tartrate) Cat No HY-10562A
Ketanserin (R41468) tartrate is a selective 5-HT2 antagonist Ketanserin tartrate alsoreceptor
blocks hERG current ( ) in aIhERG
concentration-dependent manner ( =011 μM)IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Keto ZiprasidoneCat No HY-100648
Keto Ziprasidone is an impurity of ZiprasidoneZiprasidone an antipsychotic agent is a combined5-HT (serotonin) and dopamine receptor antagonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537
Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and
( ) secretionamyloid-β Aβ
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg
Lesopitron dihydrochloride (E4424) Cat No HY-101609
Lesopitron dihydrochloride is a full and selective receptor agonist with of 125 nM in5-HT1A IC50
rat hippocampal membranes
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Levomepromazine (Methotrimeprazine) Cat No HY-B1693
Levomepromazine (Methotrimeprazine) is an orallyavailable neuroleptic agent which is commonlyused to relieve nausea and vomiting in palliativecare settings
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Lidanserin (ZK-33839) Cat No HY-101815
Lidanserin (ZK-33839) acts as a and5-HT2A
antagonistα -adrenergic receptor1
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg
LintoprideCat No HY-U00121
Lintopride is a antagonist with moderate5HT45HT3 antagonist properties
Purity 9638Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
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Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
22 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
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SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
LoxapineCat No HY-17390
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9949Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Loxapine succinateCat No HY-17390A
Loxapine Succinate is a D2DR and D4DR inhibitorserotonergic receptor antagonist and also adibenzoxazepine anti-psychotic agent
Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
LP-211Cat No HY-111455
LP-211 is a selective and bloodminusbrain barrierpenetrant agonist with a of5-HT receptor7 Ki
058 nM with high selectivity over 5-HT1A
receptor (K 188 nM) and D receptor (K 142 nM)i 2 i
Purity 9961Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Lumateperone tosylate (ITI-007 tosylate) Cat No HY-19733
Lumateperone tosylate (ITI-007 tosylate) is a5-HT2A receptor antagonist (Ki = 054 nM) apartial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32nM) and a SERT blocker (Ki = 61 nM)
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Lurasidone (SM-13496) Cat No HY-B0032A
Lurasidone (SM-13496) is an antagonist of both and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively Lurasidone (SM-13496)is also a partial agonist of receptor5-HT1A
with an of 675 nMIC50
Purity 9949Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Lurasidone Hydrochloride (SM-13496 Hydrochloride) Cat No HY-B0032
Lurasidone (Hydrochloride) (SM-13496(Hydrochloride)) is an antagonist of both
and with s of 168dopamine D2 5-HT7 IC50
and 0495 nM respectively
Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg
LY 344864Cat No HY-13788
LY 344864 is a selective receptor agonist with anaffinity of 6 nM (Ki) at the recently cloned5-HT1F receptor IC50 Value 6 nM (Ki) Target5-HT1F LY 344864 possesses little affinity for the56 other serotonergic and non-serotonergicneuronal binding sites examined
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
LY 344864 hydrochlorideCat No HY-13788B
LY 344864 hydrochloride is a selective 5-HT1Fagonist with a of 6 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY 344864 racemateCat No HY-13788C
LY 344864 racemate is a agonist5-HT receptor1F
extracted from patent US 5708187 A
Purity 9888Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
LY 344864 S-enantiomerCat No HY-13788A
LY 344864 S-enantiomer is the S-enantiomer ofLY344864 LY344864 is a 5-HT1F receptor agonist
Purity 9962Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg
wwwMedChemExpresscom 17
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
18 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
22 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
LY310762Cat No HY-13527
LY310762 is a 5-HT1D receptor antagonist with Kiof 249 nM having a weaker affinity for 5-HT1Breceptor IC50 value 249 nM (Ki) Target 5-HT1Din vitro LY310762 has a higher affinity for theguinea pig 5-HT1D receptor than for the 5-HT1Breceptor
Purity 9984Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
LY320135Cat No HY-W011040
LY320135 is a potent and selective antagonist of receptor with a of 141 nM LY320135 alsoCB1 Ki
binds to and with5-HT2 muscarinic receptorss of 64 μM and 21 μM respectively LY320135Ki
exhibits neuroprotective effect
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
LY334370Cat No HY-103107
LY334370 is a selective receptor agonist5-HT1F
with a of 16 nMKi
Purity 9980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Masupirdine mesylate (SUVN-502 mesylate) Cat No HY-109118A
Masupirdine mesylate (SUVN-502 mesylate) is apotent selective orally bioavailable and brainpenetrant antagonist ( of 2045-HT6 receptor Ki
nM for human 5-HT6 receptor)
Purity gt98Clinical Data Phase 2Size 10 mM times 1 mL 1 mg
Melitracen hydrochlorideCat No HY-108256
Melitracen hydrochloride is an orally activebiphasic antidepressant and antianxiety agentMelitracen hydrochloride can inhibit the uptake ofNorepinephrine and through the5-HT (serotonin)presynaptic membrane inducing the increase ofmonoamine transmitters in synaptic space
Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
MetergolineCat No HY-B1033
Metergoline is a psychoactive drug of the ergolinechemical class which acts as a ligand for variousserotonin and dopamine receptors
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Methiothepin mesylate (Metitepine mesylate Ro 8-6837 mesylate) Cat No HY-107836
Methiothepin mesylate is a potent andnon-selective antagonist with5-HT receptor2
p s of 710 (5-HT ) 728 (5HT ) 756Kd 1A 1B
(5HT ) 699 (5HT ) 70 (5-HT ) 781C 1D 5A
(5-HT ) 874 (5-HT ) and 899 (5-HT ) and5B 6 7
p s of 850 (5HT ) 868 (5HT ) andhellipKi 2A 2B
Purity 9932Clinical Data No Development ReportedSize 10 mg
Methylergometrine maleate (Methylergonovine maleate Ryegonovin Spametrin F) Cat No HY-100988
Methylergometrine maleate (Methylergonovinemaleate) is an ergot alkaloid and an activemetabolite of Methysergide with vasoconstrictiveand uterotonic activity
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg
MHP 133Cat No HY-101653
MHP 133 is a drug with multiple CNS targets andinhibits acetylcholinesterase (AChE) with of 69Ki
μM also active against muscarinic M1 and M2receptors serotonin 5HT4 receptors and imidazoleI2 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mirtazapine (Org3770 6-Azamianserin) Cat No HY-B0352
Mirtazapine (Org3770) is a potent and orallyactive noradrenergic and specific serotonergicantidepressant (NaSSA) agent Mirtazapine is alsoa and5-HT2 5-HT3 histamine H1 receptor
antagonist with values ofα2-adrenoceptor pKi
805 81 93 and 695 respectively
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
18 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
22 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) Cat No HY-B0352S
Mirtazapine D3 (Org3770 D3 6-Azamianserin D3) isa deuterium labeled Mirtazapine Mirtazapine is a
inhibitor Mirtazapine is a potent5-HT receptorand orally active noradrenergic and specificserotonergic antidepressant (NaSSA) agent byblocking 5-HT2 and 5-HT3 receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ML 10302 hydrochlorideCat No HY-14442
ML 10302 hydrochloride is a potent and selective agonist with an of 45-HT receptor4 EC50
nMML 10302 hydrochloride displays more than680-fold selectivity over receptor in5-HT3
binding assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mosapride (TAK-370 AS-4370) Cat No HY-B0189
Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist Target 5HT4 Mosaprideis a gastroprokinetic agent that acts as aselective 5HT4 agonist
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Mosapride citrate (TAK-370 citrate AS-4370 citrate) Cat No HY-B0189A
Mosapride citrate is a gastroprokinetic agent thatacts as a selective 5HT4 agonist Target 5HT4Mosapride is a gastroprokinetic agent that acts asa selective 5HT4 agonist
Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Myristicin (Myristicine) Cat No HY-N2510
Myristicine act as a serotonin receptorantagonist a weak monamine oxidase (MAO)inhibitor Myristicine is the main component ofnutmeg essential oil from Myristica
Houttfragrans
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Naftidrofuryl oxalate (Nafronyl oxalate salt) Cat No HY-B1107
Naftidrofuryl oxalate (Nafronyl oxalate salt) is adrug used in the management of peripheral andcerebral vascular disorders as a vasodilatorenhance cellular oxidative capacity and may alsobe a 5-HT2 receptor antagonist
Purity 9581Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
NAN-190 hydrobromideCat No HY-19818A
NAN-190 hydrobromide is a serotonin receptor 5-HTantagonist NAN-190 is a selective antagonist of
5-HT1A
Purity 9902Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
Naratriptan (GR-85548A) Cat No HY-B0197
Naratriptan is a selective 5-HT1 receptor subtypeagonist and is a triptan drug that is used for thetreatment of migraine headaches Target 5-HT1Receptor Naratriptan is a triptan drug marketed byGlaxoSmithKline and is used for the treatment ofmigraine headaches
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Naratriptan D3 Hydrochloride (GR-85548A D3) Cat No HY-B0197AS
Naratriptan D3 Hydrochloride is the deuteriumlabeled Naratriptan which is a selective 5-HT1receptor subtype agonist
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Naratriptan hydrochloride (GR-85548A hydrochloride) Cat No HY-B0197A
Naratriptan hydrochloride is a selective 5-HT1receptor subtype agonist and is a triptan drugthat is used for the treatment of migraineheadaches
Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
wwwMedChemExpresscom 19
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
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Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396
Nefazodone hydrochloride (BMY-13754) is a potentand selective ( =58 nM) antagonist with5HT2A Ki
moderate inhibition of 5-HT and noradrenalineuptake ( of 290 and 300 nM respectively)IC50
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Nelotanserin (APD125) Cat No HY-10559
Nelotanserin is a potent inverse agonist5-HT2A
a moderately potent partial inverse5-HT2C
agonist and a weak inverse agonist with5-HT2B
of 17 79 791 nM in IP accumulationIC s50
assays respectively
Purity 9979Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Nemifitide diTFA (INN 00835 diTFA) Cat No HY-105077A
Nemifitide diTFA (INN 00835 diTFA) is a syntheticpentapeptide antidepressant with a potential forrapid onset of action Nemifitide diTFA is apeptide analog of melanocyte-inhibiting factor(MIF) Nemifitide diTFA can cross the blood-brainbarrier
Purity 9913Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
NEO 376 (SPI-376) Cat No HY-101583
NEO 376 is a selective modulator of 5-HT1 and receptor GABA receptor dopamine with anti-psychotic activelyreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Nexopamil racemateCat No HY-101727
Nexopamil racemate is the racemate of NexopamilNexopamil is a combined antagonistCa2+ 5-HT2
on thrombus formation in vivo and on plateletaggregation in vitro
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NPS ALX Compound 4aCat No HY-103090
NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine (5-HT ) receptor6 6
antagonist with an of 72 nM and a of 02IC50 Ki
nM
Purity gt990Clinical Data No Development ReportedSize 5 mg
NRA-0160Cat No HY-101641
NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi
negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki
( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
NuciferineCat No HY-N0049
Nuciferine is an antagonist at ( =4785-HT2A IC50
nM) ( =131 nM) and ( =15-HT2C IC50 5-HT2B IC50
μM) an inverse agonist at ( =150 nM)5-HT7 IC50
a partial agonist at ( =64 nM) D2 EC50 D5
( =26 μM) and ( =700 nM) anEC50 5-HT6 EC50
agonist at ( =32 μM) andhellip5-HT1A EC50
Purity 9966Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Ocaperidone (R79598) Cat No HY-101094
Ocaperidone is an effective antipsychotic agentacting as a potent and 5-HT2 dopamine D2
antagonist and a agonist with s of5-HT1A Ki
014 nM 046 nM 075 nM 16 nM and 54 nM for5-HT a -adrenergic receptor dopamine D 2 1 2
histamine H and a -adrenergichellip1 2
Purity 9855Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Olanzapine (LY170053) Cat No HY-14541
Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin
( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki
nM respectively) ( =11 to 31dopamine D1-4 Ki
nM) ( =19-25 nM) andmuscarinic M1-5 Ki
( =19 nM)adrenergic α1 receptor Ki
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg
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Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
22 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Olanzapine D3 (LY170053 D3) Cat No HY-14541S
Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ondansetron (GR 38032 SN 307) Cat No HY-B0002B
Ondansetron(GR 38032 SN 307) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity 9941Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Ondansetron hydrochloride (GR 38032 hydrochloride SN 307 hydrochloride) Cat No HY-B0002
Ondansetron hydrochloride (GR 38032 hydrochlorideSN 307 hydrochloride) is a serotonin 5-HT3receptor antagonist used mainly as anantiemetic(to treat nausea and vomiting) often followingchemotherapy
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride
dihydrate SN 307 hydrochloride dihydrate) Cat No HY-B0002A
Ondansetron hydrochloride dihydrate (GR 38032hydrochloride dihydrate SN 307 hydrochloridedihydrate) is a serotonin 5-HT3 receptorantagonist used mainly as anantiemetic (to treatnausea and vomiting) often followingchemotherapy
Purity 9987Clinical Data LaunchedSize 50 mg 100 mg 1 g 5 g
OPC-14523 free baseCat No HY-116594
OPC-14523 free base is an orally active sigmaand agonist with high affinity5-HT1A receptorfor sigma receptors (σ12 =4756 nM) theIC50
5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 free baseIC50
shows antidepressant-like activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OPC-14523 hydrochlorideCat No HY-116594A
OPC-14523 hydrochloride is an orally active and agonist with highsigma 5-HT1A receptor
affinity for sigma receptors (σ12 =4756 nM)IC50
the 5-HT1A receptor ( =23 nM) and the 5-HTIC50
transporter ( =80 nM) OPC-14523 hydrochlorideIC50
shows antidepressant-like activity
Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
OpiranserinCat No HY-109067
Opiranserin a non-opioid and non-NSAID analgesiccandidate is a dual antagonist of glycine
and transporter type 2 (GlyT2) serotonin receptor 2A with s of 086 and 13 μM(5HT2A) IC50
respectively Opiranserin shows antagonisticactivity on rP2X3 (IC =087 μM)50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Org-12962Cat No HY-118152
Org-12962 is a potent selective and orally active agonist with a5-HT receptor2C
value of 701 Org-12962 also exhibitspEC50
high effacy for the 5-HT and 5-HT2A 2B
receptor with s of 638 and 628pEC50
respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Org-12962 hydrochlorideCat No HY-21994
Org 12962 hydrochloride is a potent selective andefficacious 5-HT receptor agonist and2C
exhibits values of 701 638 and 628pEC50
for 5-HT 5-HT and 5-HT 2C 2A 2A
respectively Org 12962 hydrochloride is effectivein panic-like anxiety animal modelltbrgt
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OxatomideCat No HY-123205
Oxatomide is a potent and orally active dual and H1-histamine receptor P2X7 receptor
antagonist with antihistamine and anti-allergicactivity Oxatomide almost completely blocks theATP-induced current in human P2X7 receptors( of 095 μM)IC50
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 21
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
22 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
p-MPPI hydrochlorideCat No HY-120738
p-MPPI hydrochloride is a selective 5-HT1A antagonist with high affinity for 5-HT1Areceptor
receptors p-MPPI hydrochloride can crosses theblood-brain barrier and has clear antidepressantand anxiolytic-like effects
Purity 9919Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019
Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine
antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at
and receptors andα1 α2 adrenergic receptorsH1-histaminergic
Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat No HY-A0019A
Paliperidone palmitate (9-Hydroxyrisperidonepalmitate) an atypical long-acting antipsychoticagent is an ester prodrug of PaliperidonePaliperidone is a antagonist anddopamine
antagonist of the atypical antipsychotic5-HT2Aclass
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 10 mg
PalonosetronCat No HY-A0018
Palonosetron is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Palonosetron HydrochlorideCat No HY-A0021
Palonosetron Hcl is a 5-HT3 antagonist used in theprevention and treatment of chemotherapy-inducednausea and vomiting (CINV)
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
Pancopride (LAS 30451) Cat No HY-19684
Pancopride is a new potent and selective 5-HT3
antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Pardoprunox (SLV-308 DU-126891) Cat No HY-14958
Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin
agonist with s of 8 925-HT1A receptor pEC50
and 63 respectively
Purity gt98Clinical Data Phase 3Size 1 mg 5 mg
Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A
Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor
and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50
Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Peptide 401Cat No HY-12537
Peptide 401 a potent mast cell degranulatingfactor from bee venom suppresses the increasedvascular permeability due to intradermal injectionof various smooth muscle spasmogens ( histamineand )5-HT
Purity 9829Clinical Data No Development ReportedSize 500 μg 1 mg 5 mg
Perospirone (SM-9018 free base) Cat No HY-B0731A
Perospirone (SM-9018 free base) is an orallyactive antagonist of receptor ( =06 nM)5-HT2A Ki
and receptor ( =14 nM) anddopamine D2 Ki
also a partial agonist of receptor5-HT1A
( =29 nM)Ki
Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
22 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
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Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Perospirone hydrochloride (SM-9018) Cat No HY-B0731
Perospirone hydrochloride (SM-9018) is an orallyactive antagonist of receptor ( of 065-HT2A Ki
nM) and receptor ( of 14 nM)dopamine D2 Ki
Perospirone hydrochloride is also a partialagonist of receptor ( of 29 nM)5-HT1A Ki
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PerphenazineCat No HY-A0077
Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A
receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki
56 10 0765013 34 and 8 nM respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Perphenazine D8 DihydrochlorideCat No HY-A0077AS
Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
PF-04995274Cat No HY-18137
PF-04995274 is a potent high-affinity orallyactive and partial serotonin 4 receptor (5-HT R)4
agonist
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Phenylbiguanide (N-Phenylbiguanide PBG 1-Phenylbiguanide) Cat No HY-101331
Phenylbiguanide is a selective5-HT receptor3
agonist with an of 30plusmn01 μMEC50
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Piboserod (SB-207266) Cat No HY-15574
Piboserod (SB 207266) is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity 9912Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg
Piboserod hydrochloride (SB-207266 hydrochloride) Cat No HY-15574A
Piboserod (SB 207266) Hcl is a selective 5-HT(4)receptor antagonist IC50 value Target 5-HT4antagonist in vitro Piboserod did not modify thebasal contractions but concentration-dependentlyantagonized the ability of 5-HT to enhance bladderstrip contractions to EFS
Purity gt98Clinical Data Phase 2Size 1 mg 5 mg
Pimavanserin (ACP-103) Cat No HY-14557
Pimavanserin is a selective inverse agonist of the receptor with and of 873 and5-HT2A pIC50 pKd
93 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimavanserin tartrate (ACP-103 tartrate) Cat No HY-14557A
Pimavanserin tartrate (ACP-103) is a potent 5-HT receptor inverse agonist with and of2A pIC50 pKi
873 and 93 respectively
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Pimethixene (Pimetixene) Cat No HY-B1101
Pimethixene is antihistamine and antiserotonergiccompound acts as an antimigraine agent
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
wwwMedChemExpresscom 23
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A
Pimethixene maleate is antihistamine andantiserotonergic compound acts as an antimigraineagent
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
Pindolol (LB-46) Cat No HY-B0982
Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Pipamperone (Floropipamide McN-JR 3345 R 3345) Cat No HY-100703
Pipamperone (Floropipamide McN-JR 3345 R 3345)is a high-affinity antagonist of 5-HT2A
( =82) and ( =80)receptor pKi D receptor4 pKi
and a low-affinity antagonist of D receptor2
(pK =67)i
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pizotifen (Pizotyline BC-105) Cat No HY-B0115
Pizotifen (Pizotyline) is a potent 5-HT2
receptor antagonist with a high affinity for binding site5-HT1C
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
Pizotifen malate (Pizotyline malate BC-105 malate) Cat No HY-B0115A
Pizotifen malate (Pizotyline malate) is a potent receptor antagonist with a high affinity5-HT2
for binding site5-HT1C
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
PNU-142633Cat No HY-103131
PNU-142633 is a high affinity selective andorally active agonist with s5-HT receptor1D Ki
of 6 nM and gt 18 000 nM for human 5-HT1D
and human 5-HT receptorreceptor 1B
respectively PNU-142633 has anti-migraineefficacy
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg
PrucaloprideCat No HY-14151
Prucalopride (R093877) is a drug acting as aselective high affinity 5-HT4 receptoragonist(pKi=8681 for 5-HT4a4b) gt150-foldhigher affinity for 5-HT4 receptors than for otherreceptors
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Prucalopride succinate (R-108512) Cat No HY-12694
Prucalopride succinate is a selective highaffinity 5-HT4 receptor agonist with pKi of8681 for 5-HT4a4b
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg
PRX-08066Cat No HY-15472
PRX-08066 is a selective 5-hydroxytryptaminereceptor 2B (5-HT2BR IC50= 34 nM) antagonistthat causes selective vasodilation of pulmonaryarteries
Purity 9704Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PU02Cat No HY-103118
PU02 a derivative of 6-MP (HY-13677) is anegative allosteric modulator (NAM) of 5-HT3
with values of 036 and 073 μM inreceptor IC50
HEK293 cells transfected with human 5-HT A and3
5-HT AB receptors respectively3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
PuerarinCat No HY-N0145
Puerarin an isoflavone extracted from Radix is a receptor antagonistpuerariae 5-HT2C
Purity 9920Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Pumosetrag Hydrochloride (MKC-733 DDP-733) Cat No HY-19650
Pumosetrag Hydrochloride (MKC-733 DDP-733) is anorally available partial agonist developed5-HT3for the treatment of irritable bowel syndrome andgastroesophageal reflux disease
Purity 9977Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Quetiapine (ICI204636) Cat No HY-14544
Quetiapine (ICI204636) is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine is a dopamine receptorantagonist with a of 633 for human D2pIC50
receptor
Purity 9996Clinical Data LaunchedSize 10 mg 50 mg 100 mg
Quetiapine D4 fumarateCat No HY-B0031S
Quetiapine D4 fumarate is the deuterium labeledQuetiapine fumarate Quetiapine fumarate is a 5-HTreceptors agonist and a dopamine receptorantagonist Antidepressant and anxiolytic effects
Purity gt980Clinical Data No Development ReportedSize 1 mg
Quetiapine D4 hemifumarateCat No HY-B0031S1
Quetiapine D4 hemifumarate is the deuteriumlabeled Quetiapine hemifumarate Quetiapinehemifumarate is a 5-HT receptors agonist and adopamine receptor antagonist Antidepressant andanxiolytic effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Quetiapine hemifumarateCat No HY-B0031
Quetiapine hemifumarate is a 5-HT receptorsagonist with a of 477 for human 5-HT1ApEC50
receptor Quetiapine hemifumarate is a dopamine antagonist with a of 633 forreceptor pIC50
human D2 receptor
Purity 9824Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
R 59-022 (DKGI-I Diacylglycerol kinase inhibitor I) Cat No HY-107613
R 59-022 (DKGI-I) is a diacylglycerol kinaseinhibitor ( =28 μM) R 59-022 is a IC50 5-HTRantagonist and activates protein kinase C (PKC)
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ramosetron Hydrochloride (YM060) Cat No HY-B0595
Ramosetron Hydrochloride(YM060 Hydrochloride) is aserotonin 5-HT3 receptor antagonist for thetreatment of nausea and vomiting Target 5-HT3Receptor Ramosetron hydrochloride selectivelyblocks serotonin receptors (5-HT3)
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
RevexeprideCat No HY-U00373
Revexepride is a highly selective 5-HT4 receptoragonist and a potential inducer of CYP3A4
used for the treatment ofenzymegastroesophageal reflux disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 25
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
RG-12915Cat No HY-19110
RG-12915 is a selective antagonist with5-HT3 value of 016 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Risperidone (R 64 766) Cat No HY-11018
Risperidone is a serotonin 5-HT receptor2
blocker inhibitor and potentP-Glycoprotein antagonist with ofdopamine D receptor2 K si
48 59 nM for 5-HT and dopamine D receptor2A 2
respectively
Purity 9916Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A
Risperidone hydrochloride (R 64 766 hydrochloride) blocker inhibitor5-HT receptor2 P-Glycoprotein
and potent antagonistdopamine D receptor2
with of 48 59 nM for 5-HT and dopamineK si 2A
D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B
Risperidone mesylate(R 64 766 mesylate) is aserotonin blocker 5-HT receptor2 P-Glycoproteininhibitor and potent dopamine D receptor2
antagonist with of 48 59 nM for 5-HTK si 2A
and dopamine D receptor respectively2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ritanserin (R 55667) Cat No HY-10791
Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50
09 nM less active on Histamine H Dopamine1
D Adrenergic α Adrenergic α receptors2 1 2
Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg
Rizatriptan benzoate (MK 462) Cat No HY-B0206
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonisttriptan drug for the treatment of migraineheadaches Target 5-HT1 agonist RizatriptanBenzoate(Maxalt) is a 5-HT1 agonist triptan drugfor the treatment of migraine headaches
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ro 04-6790Cat No HY-14335
Ro 04-6790 is a potent competitive and selective receptor antagonist with values of5-HT6 pKi
726 735 for rat and human 5-HT6 receptorsrespectively Ro 04-6790 has no affinity at otherreceptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Roluperidone (CYR-101 MIN-101 MT-210) Cat No HY-19469
Roluperidone (CYR-101) is a novel cyclic amidederivative that has high equipotent affinities for
and receptors ( of 753 nM5-HT2A sigma-2 Ki
and 819 nM for 5-HT and sigma-22A
respectively)
Purity 9808Clinical Data Phase 3Size 10 mM times 1 mL 2 mg 5 mg 10 mg 50 mg 100 mg
Rotigotine (N-0437 N-0923) Cat No HY-75502
Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor
and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki
4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki
of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip
Purity 9939Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg
26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096
Rotundine is an antagonist of dopamine D1 D2and with s of 166 nM 14 μMD3 receptors IC50
and 33 μM respectively Rotundine is also anantagonist of with an of 370 nM5-HT1A IC50
Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
RS-127445Cat No HY-15419A
RS-127445 is a selective high affinity orallybioavailable antagonist with a5-HT receptor2B
of 95 RS-127445 shows 1000 fold selectivitypKi
for this receptor as compared to numerous otherreceptor and ion channel binding sites
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
RS-127445 hydrochlorideCat No HY-15419
RS-127445 hydrochloride is a selective highaffinity orally bioavailable 5-HT receptor2B
antagonist with a of 95 RS-127445pKi
hydrochloride shows 1000 fold selectivity for thisreceptor as compared to numerous other receptorand ion channel binding sites
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969Cat No HY-16688
RU 24969 is a preferential agonist with5-HT1B
a of 038 nM but also displays appreciableKi
affinity for the ( =25 nM)5-HT receptor1A Ki
and has low affinity for other receptor sites inthe brain RU 24969 could decrease fluidconsumption and increase forward locomotion
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
RU 24969 hemisuccinateCat No HY-16688B
RU 24969 hemisuccinate is a preferential 5-HT1B
agonist with a of 038 nM but also displaysKi
appreciable affinity for the 5-HT receptor1A
( =25 nM) and has low affinity for otherKi
receptor sites in the brain
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Sarpogrelate hydrochloride (MCI-9042) Cat No HY-10564
Sarpogrelate hydrochloride (MCI-9042) is aselective antagonist with s of 8525-HT R2 pKi
657 and 743 for 5-HT 5-HT and 5-HT2A 2B 2C
receptors respectively
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
SB 242084Cat No HY-13409
SB 242084 is a 5-HT2C receptor antagonist(pKi=90)that displays 158- and 100-fold selectivity over5-HT2A and 5-HT2B receptors respectively
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 242084 hydrochlorideCat No HY-13409A
SB 242084 hydrochloride is a 5-HT2C receptorantagonist(pKi=90) that displays 158- and100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
SB 243213Cat No HY-103112B
SB 243213 is an orally active selective andhigh-affinity antagonist with a5-HT receptor2C
of 937 and a of 98 for human 5-HTpKi pKb 2C
receptor SB 243213 shows greater than a 100-foldselectivity over a wide range of neurotransmitterreceptors enzymes and ion channels
Purity 9862Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 243213 dihydrochlorideCat No HY-103112A
SB 243213 dihydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 27
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB 243213 hydrochlorideCat No HY-103112
SB 243213 hydrochloride is an orally activeselective and high-affinity 5-HT receptor2C
antagonist with a of 937 and a of 98pKi pKb
for human 5-HT receptor2C
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
SB 258719Cat No HY-U00443
SB 258719 is a selective 5-HT receptor7
antagonist with a of 75pKi
Purity 9916Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SB 271046 Hydrochloride (SB 271046A) Cat No HY-14336A
SB 271046 Hydrochloride (SB 271046A) is a potentselective and orally active 5-HT6 receptorantagonist with of 902 855 and 881 forpKi
rat pig and human respectively
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-200646Cat No HY-103129A
SB-200646 is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646 is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-200646ACat No HY-103129
SB-200646A is the first selective over5-HT2B2C
5-HT receptor antagonist with values of2A pKi
75 69 and 52 for and5-HT2B 5-HT2C
5-HT respectively SB-200646A is orally active2A
and has electrophysiological and anxiolyticproperties in vivo
Purity 9947Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-215505Cat No HY-18596
SB-215505 is a potent and subtype-selective receptor antagonist with values of5-HT2B pKi
83 677 766 for 5-HT 5-HT 5-HT 2B 2A 2C
respectively SB-215505 increases wakefulness andmotor activity in rats
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-224289 hydrochloride (SB-224289A) Cat No HY-101105A
SB-224289 hydrochloride is a selective 5-HT1B antagonist with anxiolytic effectreceptor
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SB-269970Cat No HY-15370
SB269970 is a antagonist with 5-HT7 receptor pKiof 83 exhibits gt50-fold selectivity againstother receptors
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SB-269970 hydrochloride (SB-269970A) Cat No HY-15370A
SB269970 hydrochloride (SB-269970A) is ahydrochloride salt form of SB-269970 which is a
antagonist with the of 835-HT7 receptor pKi
exhibits gt50-fold selectivity against otherreceptors
Purity 9877Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
SB-277011 hydrochloride (SB-277011A hydrochloride) Cat No HY-10847B
SB-277011 hydrochloride (SB-277011A hydrochloride)is a potent selective orally bioavailable andbrain penetrate dopamine D receptor3
antagonist with values of(D R)3 Ki
107 nM and 112 nM at rodentand human D R respectively3
Purity 9822Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SB-399885 hydrochlorideCat No HY-103099
SB-399885 hydrochloride is a 5-HT receptor6
antagonist
Purity 9893Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-616234-ACat No HY-19477
SB-616234-A is a selective and orally bioavailable antagonist with anxiolytic and5-HT1B receptor
antidepressant activity
Purity 9814Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB228357Cat No HY-103154
SB228357 is a selective potent and orall active antagonist with values5-HT receptor2C2B pKi
of 69 80 and 90 for and5-HT2A 5-HT2B
respectively SB228357 has5-HT2C
antidepressantanxiolytic effects
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) Cat No HY-19545A
SCH-23390 hydrochloride (R-(+)-SCH-23390hydrochloride) is a potent and selective
antagonist with sdopamine D -like receptor1 Ki
of 02 nM and 03 nM for the and D1 D5
respectivelyreceptor
Purity 9931Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat No HY-108400
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is apotent and selective dopamine D -like receptor1
antagonist with s of 02 nM and 03 nM for theKi
and respectivelyD1 D receptor5
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
SEP-363856 hydrochloride (SEP-856 hydrochloride) Cat No HY-136109
SEP-363856 hydrochlorideSEP-856 hydrochloridean orally active and CNS active psychotropic agentwith a unique non-D25-HT2A mechanism of actionexerts its antipsychotic-like effects SEP-363856hydrochlorideSEP-856 hydrochloride has thepotential for the treatment of schizophrenia
Purity 9978Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride 5-HT hydrochloride) Cat No HY-B1473
Serotonin hydrochloride is a monoamineneurotransmitter in the CNS and an endogenous
agonist Serotonin hydrochloride5-HT receptoris also a ( )catechol O-methyltransferase COMTinhibitor with a of 44 μMKi
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Sertindole (Lu 23-174) Cat No HY-14543
Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Setiptiline (Org-8282) Cat No HY-32329
Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Setiptiline maleate (MO-8282) Cat No HY-32329A
Setiptiline (MO-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)
Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 29
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SKF-83566Cat No HY-103430A
SKF-83566 is a potent blood-brain permeableand orally active D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
SKF-83566 hydrobromideCat No HY-103430
SKF-83566 hydrobromide is apotent blood-brain permeable and orallyactive D1-like dopamine receptor
antagonist and a weaker competitive(D1DR)antagonist at the vascular 5-HT receptor2
( =11 nM)Ki
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg
Spiperone hydrochloride (Spiroperidol hydrochloride) Cat No HY-B1371A
Spiperone hydrochloride (Spiroperidolhydrochloride) is a selective dopamine D2
( values of 006 nM 06 nM 008 nMreceptor Ki
~350 nM ~3500 nM for D D D and DD2 3 4 1 5
receptors respectively) and 5-HT 5-HT2A 1A
( s of 1 nM49 nM)hellipreceptor Ki
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Spiramide (AMI-193) Cat No HY-100971
Spiramide (AMI-193) is a potent and selectiveantagonist of and 5-HT2 dopamine D2
with s of 2 nM and 3 nMreceptor Ki
respectively Spiramide has gt2000-foldselectivity for 5-HT versus ( =43002 5-HT1C Ki
nM) receptors
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SR 57227ACat No HY-102064
SR 57227A is a potent orally active and selective agonist with ability to cross5-HT3 receptor
the blood brain barrier
Purity 9957Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Strictosidinic acidCat No HY-N7514
Strictosidinic acid an orally active glycosideindole monoterpene alkaloid isolated from
leaves inhibits precursorPsychotria myrianthaenzymes of biosynthesis and reduces the 5-HT5-HTlevels Strictosidinic acid has peripheralanalgesic and antipyretic activities in mice
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sulamserod (RS-100302) Cat No HY-101668
Sulamserod is a antagonist with5-HT4 receptorantiarrhythmic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Sumatriptan succinate (GR 43175) Cat No HY-B0121
Sumatriptan succinate (GR 43175) is a serotonin1(5-HT1) receptor agonist which is effective inthe acute treatment of migraine headache
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Syk Inhibitor IICat No HY-112390A
Syk Inhibitor II is a potent high selective andATP-competitive inhibitor with an of 41Syk IC50
nM Syk Inhibitor II inhibits release from5-HTRBL-cells with an of 460 nM Syk Inhibitor IIIC50
shows less potent against other kinases and hasanti-allergic effect
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
T 82Cat No HY-U00028
T 82 is a potent antagonist and5-HT3 inhibitor used foracetylcholinesterase (AChE)
treatment of Alzheimers Disease
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
30 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008
Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tandospirone (SM-3997) Cat No HY-14558
Tandospirone (SM-3997) is a potent and selective receptor partial agonist with a of 275-HT1A Ki
nM Tandospirone can be used for the research ofthe central nervous system disorders and theunderlying mechanisms
Purity 9941Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Tandospirone citrate (SM-3997 citrate) Cat No HY-B0061
Tandospirone citrate is a potent and selective5-HT1A receptor partial agonist (Ki = 27 nM) thatdisplays selectivity over SR-2 SR-1C α1 α2 D1and D2 receptors (Ki values ranging from1300-41000 nM)
Purity 9887Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
Tegaserod maleate (SDZ-HTF-919 HTF-919) Cat No HY-14153A
Tegaserod maleate is a selective receptor5-HT4
partial agonist and a receptor5-HT2B
antagonist Tegaserod maleate exhibits a promotileeffect throughout the gastrointestinal (GI) tract
Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Temanogrel (APD791) Cat No HY-10560
Temanogrel is a highly selective 5-HT2A
antagonist with a of 49 nMreceptor Ki
Purity 9894Clinical Data Phase 1Size 1 mg 5 mg 10 mg
Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356
Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor
unique renal vasodilatatory effects
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
TG6-10-1Cat No HY-16978
TG6-10-1 is an antagonist showsEP2low-nanomolar antagonist activity against onlyEP2 gt300-fold selectivity over human EP3 EP4and IP receptors 100-fold selectivity over EP1receptors
Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Thioridazine hydrochlorideCat No HY-B0965
Thioridazine hydrochloride is an antipsychoticdrug used in the treatment of schizophrenia andpsychosis shows D4 selectivity or serotoninantagonism
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
TianeptineCat No HY-90003
Tianeptine is a selective facilitator of 5-HTuptake Tianeptine has no affinity for a widerange of receptors including 5-HT and dopamine(IC gt10 μM) and has no effect on noradrenalin50
or dopamine uptake
Purity 9924Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Tianeptine sodium saltCat No HY-90003A
Tianeptine sodium salt is a selective facilitatorof uptake Tianeptine sodium salt has no5-HTaffinity for a wide range of receptors including5-HT and dopamine (IC gt10 μM) and has no effect50
on noradrenalin or dopamine uptake
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 31
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
TIK-301 (PD-6735 LY-156735) Cat No HY-106136
TIK-301 (PD-6735) is a chlorinated melatoninderivative and a potent high-affinity and orallyactive and melatonin MT1 MT receptors2
agonist with s of 0081 nM and 0042 nMKi
respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Trazodone hydrochloride (AF-1161) Cat No HY-B0478
Trazodone (hydrochloride) (AF-1161) is anantidepressant belonging to the class of serotoninreceptor antagonists and reuptake inhibitors fortreatment of anxiety disorders
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Trimipramine maleateCat No HY-B1213
Trimipramine maleate is a 5-HT receptorantagonist with pK s of 639 810 466 fori
5-HT 5-HT and 5-HT respectively1C 2 1A
Purity 9984Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Tropisetron (SDZ-ICS-930 free base) Cat No HY-B0072
Tropisetron (SDZ-ICS-930 free base) is a selective5-HT3 receptor antagonist and α7-nicotinicreceptor agonist with an IC50 of 701 plusmn 09 nM for5-HT3 receptor
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Tropisetron Hydrochloride (SDZ-ICS-930) Cat No HY-B0020
Tropisetron Hydrochloride (SDZ-ICS-930) is aselective 5-HT3 receptor antagonist andα7-nicotinic receptor agonist with an IC50 of 701plusmn 09 nM for 5-HT3 receptor
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
UrapidilCat No HY-B0716
Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A
Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg
Urapidil D6Cat No HY-B0716S
Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor
agonist5-HT receptor1A
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Urapidil hydrochlorideCat No HY-B0354A
Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist
Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg
Vabicaserin hydrochloride (SCA 136) Cat No HY-111200
Vabicaserin hydrochloride is a 5-hydroxytryptamine2C ( ) -selective agonist with an5-HT2C receptor
of 8 nMEC50
Purity 9899Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Vilazodone (EMD 68843 SB659746A) Cat No HY-14262
Vilazodone (EMD 68843 SB 659746A) is a potentselective and orallyactive serotonin reuptake inhibitor (SSRI)and partial agonist5-HT A receptor1
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
32 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Vilazodone Hydrochloride (EMD 68843 Hydrochloride SB659746A Hydrochloride) Cat No HY-14261
Vilazodone Hydrochloride (EMD 68843 Hydrochloride)is a transporter (SER) inhibitor andserotonin
receptor partial agonist5-HT1A
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Volinanserin (MDL100907 M 100907) Cat No HY-14940
Volinanserin is a potent and selective antagonistof with a of 036 nM and5-HT receptor2 Ki
shows 300-fold selectivity for 5-HT receptor2
over 5-HT alpha-1 and DA D receptors1c 2
Volinanserin has antipsychotic activity
Purity 9971Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Vortioxetine (Lu AA 21004) Cat No HY-15414
Vortioxetine is a inhibitor of 5-HT 5-HT 1A 1B
receptor and with 5-HT 5-HT3A 7 SERT Ki
values of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9952Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
Vortioxetine D8 (Lu AA 21004 D8) Cat No HY-15414S
Vortioxetine D8 is a deuterium labeledVortioxetine Vortioxetine is an inhibitor of
receptor and5-HT 5-HT 5-HT 5-HT1A 1B 3A 7
with values of 15 nM 33 nM 37 nM 19SERT Ki
nM and 16 nM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) Cat No HY-15414A
Vortioxetine hydrobromide is a multimodalserotonergic agent inhibits 5-HT 5-HT 1A 1B
receptor and with values5-HT 5-HT3A 7 SERT Ki
of 15 nM 33 nM 37 nM 19 nM and 16 nMrespectively
Purity 9994Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg 1 g
WAY-100635Cat No HY-10349
WAY-100635 is a potent and selective 5-HT1A
Receptor antagonist with a pIC of 887 an50
apparent pA of 971 WAY-100635 is a potent and2
selective 5-hydroxytryptamine 1A (5-HT1A) antagonist with an value of 091 nMreceptor IC50
and value of 039 nMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WAY-100635 MaleateCat No HY-10349A
WAY-100635 maleate is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an value of 091 nM and IC50 Ki
value of 039 nM WAY-100635 maleate has pIC50
values for and α1-adrenergic receptors of5-HT1A89 and 66 respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
WAY-181187 (SAX-187) Cat No HY-14340
WAY-181187 (SAX-187) is a potent and selectivefull receptor agonist with a of 22 nM5-HT6 Ki
and an of 66 nM WAY181187 mediates 5-HT6EC50
receptor-dependent signal pathways such as cAMPFyn and ERK12 kinase as specific agonist
Purity 9805Clinical Data No Development ReportedSize 5 mg 10 mg
Xaliproden hydrochloride (SR57746A SR57746 hydrochloride) Cat No HY-14604
Xaliproden hydrochloride (SR57746A) is a potentselective and orally active agonist of 5-HT1A
shows a high affinity for 5-HTreceptor 1A
specific binding sites in the rat hippocampus( =3 nM)IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Xanthotoxol (8-Hydroxypsoralen) Cat No HY-30152
Xanthotoxol (8-Hydroxypsoralen) is a biologicallyactive linear furocoumarin shows strongpharmacological activities as anti-inflammatoryantioxidant antagonistic and5-HTneuroprotective effects
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
wwwMedChemExpresscom 33
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
YL0919Cat No HY-100769
YL0919 is an orally active antidepressant agentwith dual activity as a highly seletive 5-HT
blocker and an effectiveuptake agonist ( =019 nM)5-HT receptor1A Ki
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
Zatosetron maleate (LY 277359 maleate) Cat No HY-U00234
Zatosetron maleate is a potent and selective 5HT3 antagonistreceptor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone (CP-88059) Cat No HY-14542
Ziprasidone an antipsychotic agent is a combined and 5-HT (serotonin) dopamine receptor
antagonist Ziprasidone has high affinity for rat( 34 nM)human (25 nM) 5-HT1A receptorsKi
5-HT2A (042 nM) and dopamine D2 receptors (48nM)
Purity 9869Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ziprasidone amino acid (Ziprasidone Impurity C Ziprasidone open ring impurity) Cat No HY-131255
Ziprasidone amino acid (Ziprasidone Impurity C) isan impurity of Ziprasidone Ziprasidone is acombined and 5-HT (serotonin) dopamine
antagonist Ziprasidone exhibits potentreceptoreffects of antipsychotic activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A
Ziprasidone (CP-88059) hydrochloride anantipsychotic agent is a combined 5-HT
and antagonist(serotonin) dopamine receptor
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) Cat No HY-17407
Ziprasidone (CP 88059) hydrochloride monohydratean antipsychotic agent is an orally activecombined and 5-HT (serotonin) dopamine
antagonistreceptor
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
34 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom