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ZOOPHA PARNIAN PARS Co.
www.ZOOPHACO.comZ O O P H A P A R N I A N P A R S
Z O O P H A P A R N I A N P A R S C O .
ZOOPHA PARNIAN PARS
SUITE 6 - No 34 - ZAFAR ST - SHARIATI AVE - TEHRAN. - IRAN .TELFAX : 021 - 22 25 35 00
Advantages of SALINJET to normal saline :
1- Amount of drug needed : In comparison to normal saline , the amount of SALINJET needed for same results is 1/10 to 1/20 .
2- Faster Infusion : As the drug is infused faster , signs of improvement appears faster in animals .
3- Lower Cost : Because the amount of the drug is much less .
4- Efficacy : as mentioned in mechanism section before SALINJET causes increase in osmotic pressure of vascular system and drags water from ECF ( extracellular fluid ) to vascular system , so prevents edema especially pulmonary edema in contrast to normal saline .
u With same mechanism SALINJET increases the plasma volume faster than normal saline , therefor : For example in fluid therapy of a 50kg calve with 10% dehydration the
amount of normal saline needed will be :
Resuscitation fluid = 50 × 10% = 5 lit
Maintenance fluid = 50 × 50 = 2500 CC 2.5 lit
Total Amount of Normal saline = 5 + 2.5 = 7.5 lit
If we treat this calf with SALINJET , we will use 5 CC/KG , so only 250 CC SALINJET will be needed .
In an cow with 10% dehydration , usually near 60 litres of Normal saline is needed to treat the dehydration but with use of SALINJET it will drop to ( 500-600 ) kg × 5 = 2500-3000 = 2.5 – 3 litreSo the volume of serum needed is 95% less.
1- Increases cardiac output
2- Increases arterial blood pressure
3- Increases GFR in kidneys
4- Increases tissue oxygenation all over the body
u After infusion of SALINJET, oral administration of liquids and electrolytes causes ionic balance.
How to use SALINJET
A) Amount of Administration : 4-5 cc/ kg ( body weight )
B) Rate of Administration in newborn calves :The total amount ( 250 cc ) must be used in 4-5 minutes 1 cc / kgBW per minute
C) It is recommended to use oral electrolyte solutions ( ORS , Dalton or etc ) after using SALINJET.
Make sure the animal gets enough water and electrolytes after using SALINJET
Contraindication : Don’t use in renal disease
Package : Available as 1000 cc and 250 cc
References:
1 – Radostits O.M,Blood D.C ( 2007 ) Veterinary medicine .W.B.Sanders.PP : 95-982 - BP.Smith ( 2009 ) Large animal internal med. Mosby.PP:3 - Constable P. Fluid and electrolyte therapy in ruminants.Vet clin North Anim Pract 20034 - Joachim Berchtold.Treatment of calf diarrhea : Intravenous fluid therapy .Vet clin food animal. 25 (2009) 73-995 - Kazuiki Suzuki. The effect of 7/2 hypertonic saline solution on M-Mode echocardiography indices in normovolemic dogs. J vet med sci 68(7) : 749 – 751 , 2006
Example of Approximate Amount of Fluid Required for Hydration and Maintenance Therapy
Degree of % Dehydration
Rehydration (L /24h ) Maintenance (L / 24h)
Mature (500 kg )
Horse8
124060
25-5025-50
Newborn ( 50 kg ) calf8
1246
2.5-52.5-5
Mature (700kg ) cow 812
5684 35-70
35-70
www.ZOOPHACO.comZ O O P H A P A R N I A N P A R S
SALINJET is a hypertonic solution of Nacl ( 7.2% ) , it is an aquous solution with osmolarity equal to 2460 mOsm per litre .
Normal plasma osmolarity in ruminants is 306 mOsm per litre thus solutions with osmolality between 300 and 312 is called ″ isotonic solution ″ , solutions with osmolarity more than 312 is called ″ hypertonic solution ″ and those with lower than 300 mOsm is called ″ hypotonic solution ″ .
The osmolarity of 7.2% NaCl solution ( SALINJET ) is 2460 and the osmolarity of 0.9% NaCl solution ( conventional normal saline ) is 308 mOsm , so each unit of SALINJET equals to 8 same units of normal saline .
Hypertonic solution was applied in human medicine first in 1937
The mechanism of SALINJET action in the body:
SALINJET SALINJET Indication :
SALINJET Application in dehydration :
Then the amount normal saline needed can be calculated for fluid therapy
In veterinary medicine it was first used in 1992 in United States by Canstable . this drug is currently used worldwide routinely .
1- Dehydrations2- Newborn calves problems including pneumonia , depression ( fatigue ), anorexia more than 24 hours and hypothermia less than 38 degree centigrade .3- Newborn calve diarrhea4- Lactic acidosis after carbohidrate engorgement5- Acute peritonitis6- Abomasal disease, RDA, LDA, torsion and impaction7- Coliform acute mastitis8- Acute septic metritis9- Acute diarrhea in horses such as salmonella10- Hemorrhagic shock in horses11- Esophageal obstruction in horses12- Acute intestinal obstruction in horses13- Grain engorgement in horses14- Any condition in dogs or other animals which cardiac output increase is considered such as hypovolemia , dehydrations and etc
First of all , the degree of dehydration must be determined
Fluid for resuscitation (in litre ) = body weight ( in kg ) × dehydration percentageFluid for maintenance (in cc ) = body weight ( in kg ) × 50 cc
IV infusion of SALINJET
Increasing osmolarity of blood
Absorption of water from cells , interestitialand extracellular fluid and gastrointestinal system
Increase inarterial blood
pressure
Increase incardiac output
Increase inglomerular
filtration rate(GFR ) at kidneys
Increase tissueoxygenation
in whole body
Increase of Ca 2+ concentrationin heart muscle cellsIncrease of blood volume
Increase of heartcontractility
Improves O2 transferin blood
Percentage ofwater loss
ClinicalAsessment Eye ball Depression Neck torgar per
second Mucosalcondition
0 Standing strongSuck reflex
notpresent 1> wet
1-5 Standing weakSuck reflex not present or slight 1-4 wet
6-8 SternalRecumbency
Slight eye ball Detachment
From orbit5-10 adhesive
9-10 SternalRecumbency
0.5 cm between Eyeball and
Orbit11-15 Adhesive to dry
11-12 LateralRecumbency
0.5-1 cm betweenEyeball and Orbit
16-45 dry
Z O O P H A P A R N I A N P A R S C O .
SUITE 6 - No 34 - ZAFAR ST. - SHARIATI AVE. - TEHRAN. - IRAN .TELFAX : 021 - 22 25 35 00
ZOOPHA PARNIAN PARS Co.
www.ZOOPHACO.comE - M a i l : i n f o @ z o o p h a c o . c o m