2017ANNUAL REPORT

Your Voice in Public Policy to Improve Patient Lives

Takeda Political Action Committee

Message from the Chair...............................................3

By the Numbers............................................................4

TakPAC Invests in Innovation.....................................6

TakPAC Financial Statement.......................................7

Who Makes the Decisions?.........................................8

2017 Contributions to Candidates & Committees......9

Public Policies Important to Takeda...........................12

TABLE OF CONTENTS

TakPAC’s PURPOSE

TakPAC offers eligible Takeda employees a way to join together to support the election of candidates, regardless of their political affiliation, who share our vision to drive innovation and ensure patient access.

Takeda strives on many levels to inform the U.S. public policymaking process about issues important to our work for patients.

TakPAC is Takeda’s political action committee — a fund used to help elect state and federal lawmakers who share our public policy positions related to phar-maceutical innovation, the needs of patients we serve, and matters important to our industry. This program is driven by the voluntary contributions of eligible Takeda employees and is the only legal way Takeda can provide direct support to federal and many state candidates.

TakPAC plays a crucial role in helping the Takeda Government and External Affairs (GEA) team to educate elected officials on issues affecting our prod-ucts and therapeutic areas. It is through TakPAC’s direct, bipartisan support of candidates that we can build and strengthen our relationships with lawmakers and impress upon them the important work the pharmaceutical industry accomplishes for patients worldwide.

The TakPAC Officers and Board of Advisors want you and all eligible Takeda employees to be fully informed about TakPAC’s mission to drive innovation and ensure patient access to our medicines. This annual report provides a full, transparent accounting of TakPAC’s financial performance. Our objective is to always be a good steward of employee donations, making sure you know who decides which candi-dates to support, why specific candidates received our support, and how much we contributed.

I encourage you to learn more about TakPAC at www.takedapac.com.

Rick Ascroft2017 TakPAC ChairmanSenior Vice President, Managed Markets andGovernment AffairsTakeda Pharmaceuticals U.S.A., Inc.

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MESSAGEFROM THE CHAIR

$95,648.19

33%TOTAL VOLUNTARY CONTRIBUTIONSFROM ELIGIBLE TAKEDA EMPLOYEES

INCREASEOVER 2016

$84,00055

CONTRIBUTED TOFEDERALCANDIDATES &COMMITTEES

98%TakPAC DONORSCONTRIBUTINGTHROUGH RECURRINGPAYROLL DEDUCTION

3800TAKEDA U.S. EMPLOYEESELIGIBLE TO PARTICIPATEIN TakPAC—

225%INCREASE OVER 2016

8 NEW TakPAC BOARD OFADVISORS MEMBERSREPRESENTING ALLBUSINESS UNITS & LOCATIONS

2017TakPAC BY THE NUMBERS

44

2017PACRECEIPTS

2017TakPAC BY THE NUMBERS

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TakPAC SupportsInnovation

Takeda Political Action Committee

Supports candidates whochampion policies important to Takeda

What WE Accomplishthrough TakPAC

HelpELECT

Candidates

BuildStrong

RELATIONSHIPS

EDUCATEon Takeda

Issues

HealthcareReform

MedicareReform

Drug Pricing/Transparency

Patient IssuesAccess/Step Therapy

BOTTOM LINE?Takeda can build a better environment for innovation

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REVENUECash on Hand (1/1/2017) $ 19,980.89Receipts from Voluntary Employee Donations $ 95,648.19 $ 115,629.08

DISBURSEMENTSFederal Candidates & Political Committees $ 84,000.00Operating Expenses (bank fees) $ 1,871.10

Total $ 85,871.00

Ending Balance (12/31/17) $ 29,758.08

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s

2017 TakPACFINANCIAL STATEMENT

How TakPAC Decides Who to Support• Support for innovation and positions on key issues affecting Takeda and our patients;• Representation in districts/states where Takeda facilities or employees are located;• Leadership position and membership on key committees dealing with issues important to Takeda and our patients;• Character, integrity and leadership abilities; and• Financial need and nature of the opposition.

CHAIR VICE CHAIR TREASURER ASST. TREASURER

RICHARDASCROFTSr. Vice President,Managed Marketsand GovernmentAffairs

LAURACLINEHead, Policy andAdvocacyGovernment andExternal Affairs

HELENGIZASr. Vice Presidentand Chief FinancialOfficerU.S. Business Unit

PATRICKBUTLERHead,U.S. Tax

WHO MAKES THE DECISIONS?

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2017 TakPAC Board of Advisors

OFFICERS

MEMBERSLaurene GiagnorioSVP, Human Resources &Administration, U.S. BU

Eric HahnSite Head, Biologics Operations &Engineering, Brooklyn Park

Dominika KovacsHead of Transformation Office, Research & Development

Liz LewisChief Counsel & Head of Patient Advocacy,Oncology Business Unit

Steve SchaeferSVP, General Medicine, U.S. BU

Dobson SchofieldHead of Compliance, U.S. BU

Rahul SinghviChief Operating Officer,Vaccine Business Unit

David WeitzHead, Takeda California (TCAL) & Global Research Externalization,TCAL/R&D

Political party affiliation or positions on non-business policy issues are not criteria for candidate support.

TakPAC Contributions toFederal Candidates & Leadership PACs

Candidates Party District AmountAlabamaRep. Robert Aderholt R 04 $1,000CaliforniaRep. Grace Napolitano D 36 $1,000Rep. Scott Peters D 52 $4,000Rep. Raul Ruiz D 36 $1,000Rep. Mimi Walters R 45 $1,000ColoradoSen. Michael Bennet D $1,000DelawareSen. Tom Carper D $1,000Sen. Chris Coons D $1,000FloridaRep. Carlos Curbelo R 26 $2,000HawaiiSen. Mazie Hirono D $1,000IllinoisRep. Cheri Bustos D 17 $1,000Rep. Danny Davis D 07 $1,000Sen. Tammy Duckworth D $1,000Rep. Robin Kelly D 02 $1,000Rep. Adam Kinzinger R 16 $1,000Rep. Darin LaHood R 18 $1,000Rep. Mike Quigley D 05 $1,000Rep. Peter Roskam R 06 $2,500Rep. Brad Schneider D 10 $2,500Rep. John Shimkus R 15 $1,000IndianaRep. Susan Brooks R 05 $1,000Rep. Larry Bucshon R 08 $1,000KansasRep. Kevin Yoder R 03 $1,000

2017POLITICAL

CONTRIBUTIONS

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Candidates Party District AmountMassachusettsRep. Mike Capuano D 07 $2,500Rep. Katherine Clark D 05 $1,000Rep. Joe Kennedy D 04 $1,000Sen. Ed Markey D $1,000Rep. Jim McGovern D 02 $1,000Rep. Seth Moulton D 06 $1,000Rep. Richard Neal D 01 $2,000MinnesotaRep. Erik Paulsen R 03 $2,500MissouriSen. Roy Blunt R $1,000MontanaSen. Heidi Heitkamp D $1,000New JerseyRep. Frank Pallone D 06 $1,000New MexicoRep. Ben Ray Lujan D 03 $1,000New YorkRep. Lee Zeldin R 01 $1,000North CarolinaRep. Patrick McHenry R 10 $3,000OhioRep. Pat Tiberi R 12 $5,000Rep. Brad Wenstrup R 02 $1,000OregonRep. Greg Walden R 02 $5,000Sen. Ron Wyden D $1,000PennsylvaniaRep. Ryan Costello R 06 $1,000Rep. Charlie Dent R 15 $1,000Rep. Mike Kelly R 03 $1,500TennesseeRep. Phil Roe R 01 $1,000TexasRep. Kevin Brady R 08 $1,000Rep. Bill Flores R 17 $1,000UtahSen. Orrin Hatch R $1,000WashingtonSen. Patty Murray D $2,500Rep. Cathy McMorris Rodgers R 05 $1,000WisconsinRep. Ron Kind D 03 $1,000

Total $84,000

2017POLITICAL

CONTRIBUTIONS

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Federal Political CommitteesPoliticalAffiliation Amount

Moderate Democrats PAC D $5,000New Democrats PAC D $2,500Republican Main Street Partnership PAC R $2,500

Total $10,000

2017POLITICAL

CONTRIBUTIONS

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TakPAC Contribution Limits

$5,000 per primary and general election to a federal candidate’s campaign committee.

$15,000 per calendar year to each national party committee, such as the Dem-ocratic and Republican national, senatorial and congressional campaign committees.

$5,000 per year to a federal incumbent’s leadership PAC. Leadership PACs may be sponsored by Members of Congress to support other candidates from their political party in order to position themselves for future leadership spots or committee chairmanships. These are separate from a member’s campaign committee.

$5,000 per year to a state or local party committee. Contribution limits for state and local candidates vary by state laws.

PUBLIC POLICIES IMPACT PATIENTS AND TAKEDA

Takeda’s U.S. Government and External Affairs (GEA) staff works to educate state and federal elected officials about issues affecting patients, our products and therapeutic areas, and our company. GEA also advocates for policies that reflect our patient-centric approach, and strives to be the voice for patients in public policy discussions on Capitol Hill and in state capitals across the country. Our elected leaders need to know how their decisions and policies will impact the health of patients in their district or state.

The GEA team is committed to providing information to all employees about the public policy issues that impact our company through the GEA pages on MyTakeda. We believe it is important for everyone at Takeda to understand the impact, positive and negative, that public policy decisions have on our company and the patients we serve.

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Environmentof

Innovation

TOOLSFOR

SUCCESS

EMPLOYEES ENGAGED IN TakPAC CREATEENVIRONMENT OF INNOVATION

For more information about TakPAC visit contact TakPAC@takeda.com.

One Takeda Parkway Deer�eld, IL 60015

TakPAC@Takeda.com www.TakedaPAC.com

2017ANNUAL REPORT