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YOUR MEDICATION CLOPIDOGREL Why is this medication prescribed? Clopidogrel (also known as Plavix) is an antiplatelet. It is used to reduce the risk of stroke or heart attack. It works by preventing excessive blood clotting, by helping to keep your blood platelets from sticking together. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. How should this medicine be used? Clopidogrel comes as a tablet to take by mouth.It is usually taken once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.Take clopidogrel exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Continue to take Clopidogrel even if you feel well. Do not stop taking clopidogrel without talking to your doctor. What special precautions should I follow? Before taking Clopidogrel: Tell your doctor and pharmacist if you are allergic to clopidogrel or any other drugs. Tell your doctor and pharmacist what prescription and non- prescription medications you are taking, especially anticoagulants (‘blood thinners’) such as warfarin (Coumadin); aspirin; fluvastatin (Lescol); ibuprofen (Advil, Motrin); medications for arthritis, pain, or headaches; naproxen (Naprosyn); phenytoin (Dilantin); tamoxifen (Nolvadex); ticlopidine (Ticlid); tolbutamide (Orinase); torsemide (Demadex); and vitamins. Tell your doctor if you have,or have ever had, liver or kidney disease; any stomach problems; ulcers; any other gastrointestinal disease; any bleeding or blood disorders. Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking clopidogrel, call your doctor. If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Clopidogrel. What should I do if I forget a dose? Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. What side effects can this medication cause? Although side effects from Clopidogrel are not common,they can occur. Tell your doctor if any of these symptoms are severe or do not go away: Upset stomach Fatigue, muscle aches (flu-like symptoms) Stomach pain Headache Diarrhoea Constipation Rash or purple areas on skin If you experience any of the following symptoms, call your doctor immediately: Chest pain Unusual bleeding or bruising Bloody vomit Dark urine Bloody diarrhoea or black, tarry stools Fever Confusion or coma Yellowness of the skin or eyes Blood in the urine What storage conditions are needed for this medicine? Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom cabinet).Take any medication that is outdated or no longer needed back to your pharmacist .and talk to them about the proper disposal of your medication. What other information should I know? Keep all appointments with your doctor. Your doctor may order certain laboratory tests to check your response to Clopidogrel, and will talk to you about the results. Clopidogrel helps to prevents blood from clotting so it may take longer than usual for you to stop bleeding if you are cut or injured. Avoid activities that have a high risk of causing injury. and take sensible precautions when handling knives or using gardening implements.Call your doctor if bleeding is unusual or very prolonged. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. Do not hesitate to ask your doctor any questions that you may have about your condition or the meidcation you are taking. AntiCoagulation Europe 2010 Project5 2/11/11 15:31 Page 18

Your Medicine Clopidogrel

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Your Medicine Clopidogrel

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YOUR MEDICATION CLOPIDOGREL

Why is this medicationprescribed?

Clopidogrel (also known as Plavix) isan antiplatelet. It is used to reduce therisk of stroke or heart attack. It worksby preventing excessive blood clotting,by helping to keep your blood plateletsfrom sticking together.

This medication is sometimesprescribed for other uses; ask yourdoctor or pharmacist for moreinformation.

How should this medicine beused?Clopidogrel comes as a tablet to takeby mouth. It is usually taken once a day.Follow the directions on yourprescription label carefully, and askyour doctor or pharmacist to explainany part you do not understand.Takeclopidogrel exactly as directed. Do nottake more or less of it or take it moreoften than prescribed by your doctor.Continue to take Clopidogrel even ifyou feel well. Do not stop takingclopidogrel without talking to yourdoctor.

What special precautions should I follow?Before taking Clopidogrel:

n Tell your doctor and pharmacist ifyou are allergic to clopidogrel orany other drugs.

n Tell your doctor and pharmacistwhat prescription and non-prescription medications you aretaking, especially anticoagulants(‘blood thinners’) such as warfarin(Coumadin); aspirin; fluvastatin(Lescol); ibuprofen (Advil, Motrin);medications for arthritis, pain, orheadaches; naproxen (Naprosyn);phenytoin (Dilantin); tamoxifen(Nolvadex); ticlopidine (Ticlid);tolbutamide (Orinase); torsemide(Demadex); and vitamins.

n Tell your doctor if you have, or haveever had, liver or kidney disease; anystomach problems; ulcers; any othergastrointestinal disease; any bleedingor blood disorders.

n Tell your doctor if you are pregnant,plan to become pregnant, or arebreast-feeding. If you becomepregnant while taking clopidogrel, callyour doctor.

n If you are having surgery, includingdental surgery, tell the doctor ordentist that you are takingClopidogrel.

What should I do if I forget adose?

Take the missed dose as soon as youremember it. However, if it is almosttime for the next dose, skip the misseddose and continue your regular dosingschedule. Do not take a double dose tomake up for a missed one.

What side effects can thismedication cause?

Although side effects from Clopidogrelare not common, they can occur. Tellyour doctor if any of these symptomsare severe or do not go away:

n Upset stomach

n Fatigue, muscle aches (flu-likesymptoms)

n Stomach pain

n Headache

n Diarrhoea

n Constipation

n Rash or purple areas on skin

If you experience any of the followingsymptoms, call your doctorimmediately:

n Chest pain

n Unusual bleeding or bruising

n Bloody vomit

n Dark urine

n Bloody diarrhoea or black, tarrystools

n Fever

n Confusion or coma

n Yellowness of the skin or eyes

n Blood in the urine

What storage conditions areneeded for this medicine?

Keep this medication in the container itcame in, tightly closed, and out of reachof children. Store it at roomtemperature and away from excessheat and moisture (not in thebathroom cabinet).Take any medicationthat is outdated or no longer neededback to your pharmacist .and talk tothem about the proper disposal of yourmedication.

What other information should I know?

Keep all appointments with yourdoctor. Your doctor may order certainlaboratory tests to check yourresponse to Clopidogrel, and will talkto you about the results.

Clopidogrel helps to prevents bloodfrom clotting so it may take longer thanusual for you to stop bleeding if youare cut or injured. Avoid activities thathave a high risk of causing injury. andtake sensible precautions whenhandling knives or using gardeningimplements.Call your doctor if bleedingis unusual or very prolonged.

Do not let anyone else take yourmedication. Ask your pharmacist anyquestions you have about refilling yourprescription. Do not hesitate to askyour doctor any questions that youmay have about your condition or themeidcation you are taking.

AntiCoagulation Europe 2010

Project5 2/11/11 15:31 Page 18