Embed Size (px)
Citation preview
Curriculum vitae
Date Prepared: January, 2013
Name: Patrick Leavey
Office Address: UT Southwestern Medical CenterDept. of Pediatrics/Hem/Onc5323 Harry Hines Blvd.Dallas, TX 75390-9063
Work Phone: 214-648-8594Work E-Mail: [email protected]
Work Fax: 214-648-3122
Place of Birth: Dublin, Ireland
Education
Year Degree(Honors)
Field of Study(Thesis advisor for PhDs)
Institution
1986 MB, BCh, BAO, LRCP&SI
Medicine Royal College of Surgeons in Ireland
2000 MD (degree by thesis) Neutrophil Function. Thesis advisor – Daniel Ambruso, MD
National University of Ireland
Postdoctoral Training
Year(s) Titles Specialty/Discipline(Lab PI for postdoc research)
Institution
1986-1987 Intern Internal medicine and surgery St. Lawrence’s Hospital, Dublin, Ireland
1987-1989 Senior house officer (SHO)
Internal medicine St. Vincent’s Hospital, Dublin, Ireland
1989-1990 Senior house officer (SHO)
Pediatrics Our Lady’s Hospital for Sick Children, Dublin, Ireland
1990-1992 Registrar Pediatrics Princess Margaret Hospital for Children Perth, Western, Australia
1992-1996 Fellow Pediatric Hematology/Oncology University of Colorado Health Sciences Center, Denver, Colorado
1995-1996 Marjory Wilson Fellow
Transfusion medicine Bonfils Blood CenterDenver, Colorado
1996-1998 Resident Pediatrics The Children’s Hospital and University of Colorado Health Sciences Center, Denver, Colorado
1
Current Licensure and Certification
Licensure Ireland; Australia; Colorado (expired); Texas (active)
Board and Other Certification
2006 Diplomate of the Sub-board of Pediatrics Hematology/Oncology of the American Board of Pediatrics (re-certification)
2001 Diplomate of the Sub-board of Pediatrics Hematology/Oncology of the American Board of Pediatrics (initial certification)
1998 Diplomate of the American Board of Pediatrics (initial certification)1996 Fellowship of the Royal Australasian College of Physicians (FRACP)1990 Diploma of Child Health from National University of Ireland (DCH)1989 Membership of the Royal College of Physicians of Ireland (MRCPI)
Honors and Awards
Year Name of Honor/Award Awarding Organization
2009 Faculty Teaching Award Children’s Medical Center and UT Southwestern Medical Center
1996 Trainee Investigator Award Biomedicine ’96 Medical Research1994 Trainee Investigator Award American Federation for Clinical Research1987 Presentation award Joint Irish / Welsh Pediatric Association Conference1986 First Place Final Pediatric
ExamRSCI
1986 First Place Final Pediatrics Our Lady’s Hospital
Other Honors and Awards
Year Name of Honor/Award Awarding Organization
2011, 2010 and 2002
Best Pediatric Specialists in Dallas D Magazine, Dallas, Texas
2008 Little Mo Award’ –Medical Achievement Award
Wipe out Kids Cancer, Dallas, Texas
2007 – 2008
Invited to participate in a Leadership Academy for Directors
Children’s Medical Center, Dallas
2006 Elected to – Society of Pediatric Research
Society of Pediatric Research (SPR)
2005 ‘Gift of Giving Back’ – Medical Achievement Award
Clayton Dabney Foundation for Kids with Cancer
Faculty Academic Appointments2
Year(s) Academic Title Department Academic Institution2006 – present Associate Professor Pediatrics UT Southwestern Medical Center,
Dallas1998-2006 Assistant Professor Pediatrics UT Southwestern Medical Center,
Dallas
Appointments at Hospitals/Affiliated Institutions
Year(s) Position Title Department/Division Institution1998 – present Staff Physician Center for Center and Blood
DisordersChildren’s Medical Center, Dallas, Texas
Other Professional Positions
Year(s) Position Title Institution2011 Co-Chair, AEWS1031, Randomized Phase III study for patients
with newly diagnosed Ewing SarcomaChildren’s Oncology Group
2010 Invited to be – North American Principal Investigator for an International Study in Recurrent Ewing Sarcoma
Pfizer, Inc.
2008 Chair, AEWS0521, Study of Bevacizumab (Avastin) in a Chemotherapeutic Regimen for First Recurrent Ewing Sarcoma.
Children’s Oncology Group
2007 Advisory board member – to discuss potential of insulin-like growth factor inhibition in recurrent Ewing Sarcoma
Amgen, Inc.
Major Administrative/Leadership Positions
Year(s) Position Title Institution2005 – present Director, Pediatric Hematology/Oncology
fellowship programUT Southwestern Medical Center, Dallas
2011 – present Associate Director, Clinical Affairs, Center for Cancer and Blood Disorders
Children’s Medical Center, Dallas
1998 – present Director, Orthopedic Oncology Program Children’s Medical Center, Dallas2006 – 2011 Clinical Director, Center for Cancer and
Blood DisordersChildren’s Medical Center, Dallas
2006 – 2010 Director, Pediatric Intern Recruitment UT Southwestern Medical Center, Dallas2005 – 2006 Co-director, Pediatric Intern Recruitment UT Southwestern Medical Center, Dallas2003 – 2005 Co-director, Pediatric
Hematology/Oncology fellowship program
UT Southwestern Medical Center, Dallas
1999 – 2003 Director, Pediatric Hematology/Oncology Grand Rounds
UT Southwestern Medical Center, Dallas
2003 – 2007 Director, Pediatric Oncology Tumor Board
Children’s Medical Center, Dallas
Committee Service 3
Year(s) Name of Committee Institution/OrganizationUTSW2004 – 2006 Search committee for a director for the Division
of Academic General PediatricsUT Southwestern Medical Center, Dallas
2003 – 2006 Pediatric Grand Rounds Committee UT Southwestern Medical Center, Dallas
2003 – 2004 Committee to review pediatric clinical research at UT Southwestern
UT Southwestern Medical Center, Dallas
2003 Pediatric Residency Review committee UT Southwestern Medical Center, Dallas
Hospital2010 – 2011 Workforce to review use of Mid-level providers
at Children’s Medical Center DallasChildren’s Medical Center, Dallas
2006 – present Children’s Medical Center Graduate Medical Education Committee
Children’s Medical Center, Dallas
2009 – 2010 Children’s Medical Center Interdisciplinary Care / Program Development Subcommittee
Children’s Medical Center, Dallas
2003 – 2005 Children’s Medical Center Clinical Research Advisory Committee
Children’s Medical Center, Dallas
2003 Chair, Pediatric Hematology/Oncology fellowship review committee
UT Southwestern Medical Center, Dallas
1999 – 2006 Pharmacy and Therapeutics Committee, Children’s Medical Center, Dallas
Children’s Medical Center, Dallas
Leadership in Professional Societies
Dates Society Name, memberAmerican Society of Clinical Oncology
2012 Scientific Chair, Pediatric Oral Abstract session. Annual Meeting, Chicago, ILAmerican Society of Pediatric Hematology/Oncology
2010 – present Member, Nominating Committee2009 Chair, Workshop – ‘Fellowship Program Improvement’2008 – present Chair, Fellowship Training Program Directors Committee2004 – 2008 Member, Fellowship Training Program Directors Committee
Council of Pediatric Subspecialties2012 – present Member, Executive Council2009 – present Member, Communications Committee
Federation of Pediatric Organizations2012 – present Member, FOPO Pediatric Training Across the Continuum working group
American Academy of Pediatrics2009 – present Member, PREP Hematology/Oncology Medical Advisory Board
Children’s Oncology Group4
2002 – present Member, Bone Sarcoma Steering committee2004 – 2009 Member, Young Investigators committee
Pediatric Academic Societies / Association of Pediatric Program Directors2010 Workshop chair, Fellowship Forum – ‘Successful Recruitment’
Grant Review Activities
Year(s) Name of Review Committee Organization2011 Grant review committee Team Connor Foundation2006 + 2007 Grant Review committee Curing Kids Cancer2005 – 2005 Clinical Research Advisory Committee Children’s Medical Center, Dallas
Editorial Activities
Year(s) Journal NameAd Hoc Reviewer
CancerThe Journal of PediatricsPediatric Blood and CancerJournal of Pediatric Hematology/OncologyPediatric NephrologyThe Pediatric Infectious Disease Journal
Educational workshop review2011; 2012; 2013
Society for Pediatric Research annual meeting
Grant Support
Pending:
Source: Cancer Prevention and Research Institute of Texas (CPRIT); RP120685Title: Molecularly Targeted Therapy for Soft Tissue Sarcoma in TexasRole: Co-investigator and Principal investigator Biospecimen Banking StudyAnnual amount and date: $1,383,649 – estimated start date 12/01/2012 – 11/30/2013Total amount and dates: $6,918,248 – estimated start date 12/01/2012 – 11/30/2017
Source: NCI/Children’s Oncology Group; U10 CA98543-09Title: A Phase III Randomized Trial of Adding Vincristine, Topotecan and Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing SarcomaRole: Study co-Chair; AEWS1031Annual amount and date: $23,809 (12% effort); 3/1/2012 – 2/29/2013
Current:
5
Source: St Baldrick’s Foundation Infrastructure awardTitle: Humanism and Professionalism Training for Pediatric Hematology/Oncology FellowsRole: Co-investigator (Awarded organization – ASPHO)Annual amount and dates: Total award $18,932; 2012 – 2013
Past:
Source: NCI/Children’s Oncology Group; U10 CA98543-09Title: A Phase III Randomized Trial of Adding Vincristine, Topotecan and Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing SarcomaRole: Study co-Chair; AEWS1031Annual amount and date: $23,809 (12% effort); 3/1/2011 – 2/29/2012
Source: Pfizer A4021020Title: Ph 1/Ph 2 Study of CP-751,871 in Pts w/Relapsed and/or Refractory Ewing's Sarcoma Family of TumorsRole: Institutional PIAmount and Dates: $18,540; 3/2008 – 12/2009
Source: NCI/Children’s Oncology Group; 5 U10 CA98543-07Title: To develop a national clinical trial for patients with first recurrent Ewing Sarcoma. Current concept submitted to CTEP at the NCI, proposes to randomize patients to receive adjuvant chemotherapy with or without Bevacizumab (Avastin).Role: Study chair, AEWS0521Amount and dates: $11,387; 3/01/2009 – 2/28/2010
Source: Children’s Foundation Research Grant Title: Identification of anxiety and depression in children with cancer.Role: Principal investigatorTotal amount and Dates: $63,860; 9/2008 – 8/2009
Source: Amgen, Inc.Title: Pharmacokinetic study of fractionated cyclophosphamide (CY) given to pediatric patients with solid tumors.Role: Principal InvestigatorTotal amount and Dates: $48,000; 2/2002 – 7/2005
Source: American Cancer Society and the Harold C. Simmons Comprehensive Cancer Center. Institutional Research Grant/Junior Investigator Award, IRG0219601Title: Study of doxycycline and celecoxib in a chemotherapeutic regimen for recurrent Ewing Sarcoma.Role: principal investigatorAmount and dates: $5,000; 11/2002 – 10/2003
Source: Children’s Foundation Research Grant #57
6
Title: Development of a proteomic microarray profile of cytokine/chemokine expression in pediatric patients with fever and neutropenia (F+N).Role: Principal InvestigatorAmount and Dates: $14,000; 2005 – 2006
Source: Children’s Foundation Research Grant #2Title: Pharmacokinetic study of sequential 5-day fractionated cyclophosphamide (CY) vs single day CY given to pediatric patients with solid malignancies.Role: Principal InvestigatorAmount and dates: $15,000; 2002 – 2004
Source: Children’s Foundation Research Grant #3 Title: KAI-1 expression in osteosarcoma and Ewing’s sarcoma.Role: Principal InvestigatorAmount and dates: $9,500; 2002 – 2004
Source: Amgen, Inc. Title: Evaluation of neutrophil function during administration of G-CSF to normal volunteers Role: Principal Investigator (fellow in training)Dates: 1995 – 1996
Clinical Trials Activities
Pending:
Grantor: Cancer Prevention and Research Institute of Texas (CPRIT)Title: Molecularly Targeted Therapy for Soft Tissue Sarcoma in Texas: Bio-specimen Banking StudyRole: Principal Investigator
Grantor: Children’s Oncology GroupTitle: Randomized Phase II Study of the Addition of Temsirolimus or Bevacizumab to Vincristine, Irinotecan, and Temozolomide for Patients with Relapsed or Refractory Ewing Sarcoma Role: Co-chair and senior investigator
Grantor: Multi-institution study; funding pendingTitle: Institutional study, Optimizing Technology To Increase Referral to Evidence-Based Care To Promote Optimal Mental Health in Patients With Pediatric Cancer: A Web-Based Approach Role: Co-investigator
Current:
Grantor: Single institutional study; Initial funding from Children’s Foundation Research grantTitle: Identification of anxiety and depression in children with cancer (study ongoing)Role: Principal Investigator
Grantor: Children’s Oncology Group
7
Title: AEWS1031, A Phase III Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma Role: Co-Chair
Past:
Grantor: Children’s Oncology GroupTitle: AEWS0521, Study of Bevacizumab (Avastin) in a Chemotherapeutic Regimen for First Recurrent Ewing Sarcoma.Role: Chair
Grantor: Single institution study; funding from Children’s Cancer Fund of DallasTitle: A prospective study of respiratory viral infections, cytokine expression, and clinical factors in a risk model for febrile neutropenia in children with cancer.Role: Senior Investigator
Grantor: Amgen, Inc. and Children’s Foundation Research GrantTitle: Pharmacokinetic study of fractionated cyclophosphamide (CY) given to pediatric patients with solid tumors.Role: Principal Investigator
Grantor: Children’s Oncology group and American Cancer Society and the Harold C. Simmons Comprehensive Cancer Center, Institutional Research Grant/Junior Investigator AwardTitle: Study of doxycycline and celecoxib in a chemotherapeutic regimen for recurrent Ewing Sarcoma.Role: principal investigator
Grantor: Children’s Foundation Research Grant Title: Development of a proteomic microarray profile of cytokine/chemokine expression in pediatric patients with fever and neutropenia (F+N).Role: Principal Investigator
Grantor: Children’s Foundation Research Grant Title: KAI-1 expression in osteosarcoma and Ewing’s sarcoma.Role: Principal Investigator
Grantor: Amgen, Inc. Title: Evaluation of neutrophil function during administration of G-CSF to normal volunteers Role: Principal Investigator (fellow in training)
Educational curriculum / trials
Current
Grantor: single institution curriculum; finding pendingTitle: Communication Curriculum for Pediatric Hematology/Oncology (PHO) FellowsRole: Senior investigator
Grantor: multi-institution curriculum; St. Baldrick’s Foundation and American Society of Pediatric Hematology/Oncology (ASPHO)
8
Title: Humanism and Professionalism curriculum for Pediatric Hematology/Oncology fellowsRole: Co-investigator
Past
Grantor: multi-institution curriculum; American Society of Pediatric Hematology/OncologyTitle: Career Development CurriculumRole: Co-investigator
Teaching Activities
Year(s) ActivityMedical and graduate school didactic and small group teaching2010 School of Health Professions Grand rounds in 2010: Bone sarcoma – role of the
interdisciplinary teamDissertation committees2011-2012 Student: Ellen Cook
Department/School: Department of Rehabilitation Counseling at UT Southwestern, School of Health ProfessionsDegree upon graduation: Certified Rehabilitation Counselor (CRC)
2007-present Ex-officio member of scholarship oversight committees for all pediatric hematology/oncology fellows
Qualifying examination committees2009-present American Academy of Pediatrics medical advisory board – PREP Hematology/OncologyCommittees concerned with medical and graduate student education2008-present Chair, American Society of Pediatric Hematology/Oncology (ASPHO) training directors
committee2010-present UT Southwestern Pediatric Hematology/Oncology fellowship program: steering
committee chair2010-present Children’s Medical Center (CMC) Graduate Medical Education committee2011-2013 Pediatric Academic Society (PAS) / Society of Pediatric Research (SPR): educational
workshop review committee2012 Executive committee member, Council of Pediatric Subspecialties (CoPS)2012 Member, Federation of Pediatric Organizations (FOPO) Pediatric Training Across the
Continuum working group2010 American Board of Pediatrics (ABP) invitational meeting: Subspecialty Clinical training
and Certification InitiativePostgraduate medical education (graduate & continuing medical education)1998-present UT Southwestern Pediatric Hematology/Oncology fellowship presentations
• Multiple presentations per year during fellows conferencePreparation of a CV; Bone sarcoma: Review sessions for ABP in-training examination• Orientation lectures: bone sarcoma and basics of chemotherapy
2007-present Annual meeting of the ASPHO training committee: Yearly presentations2009-present Department of Pediatrics residency
9
• Monthly lectures to inpatient pediatric residents: Bone Sarcoma2012 Department of Pediatrics Fellows core curriculum conference: Why is Scholarly activity
needed and what is the SOC?2010 Annual Pediatric Academic Societies (PAS) / Association of Pediatric Program Directors
(APPD) meeting: Workshop chair; title: Successful Recruitment2010 Annual meeting hematology program directors at the American Society of Hematology
(ASH): Successful recruitment2012 Ethics in Clinical Science Course; UT Southwestern Medical Center; Guest Faculty
Facilitator: Topic - Treatment vs. research
Post-doctoral trainees, research mentees
Research mentees:Year(s) Student Position Position upon completion
2011 – present
Wilson File Pediatric Hematology/Oncology Fellow
Fellowship continues
2011-2012 Ellen Cook Student - Department of Rehabilitation Counseling at UT Southwestern, School of Health Professions
Certified rehabilitation counselor (CRC)
2011 (summer)
Susan Wu MS1 MS 2 now a Doris Duke research fellow
2011 Jacquelyn Powers PL-3 Chief resident in Pediatrics. Now UTSW Pediatric Hematology oncology fellowship 2012
2008-2011 Carrye Cost Pediatric Hematology / Oncology Fellow
Assistant Professor of Pediatrics, Cincinnati Children’s Hospital Medical Center
2002-2006 Martha Stegner Medical Student and pediatric resident
Assistant Professor of Pediatrics UT Southwestern Medical Center Dallas
2004 Daniel Tobey Medical Student 1 yr sabbatical then MSII, UT Southwestern; Now in private law practice
2000 Michael Day Medical Student Pediatric resident Rhode Island; Pediatric Cardiology Fellow, Children’s Hospital Boston; Assistant Professor Pediatrics, UT Southwestern Medical Center
Fellows graduated fellowship program (since 2005 when PL became Director of Program)Fellowship
YearsFellow # Publications during
fellowship +/or subsequent to
fellowship research**
Grants/Awards Position upon completion
2009 – 2012
Raven Cooksey 1 1.Call for Cash, Children’s Cancer Fund of Dallas
Assistant Professor of Pediatrics - Children’s Hospital of the King’s Daughter, Norfolk, VA
2009 – 2012
Scott Furlan 1 in preparation 1.Selected for platform presentation at annual fellows research day
2.Children’s Cancer Fund of Dallas Research fellow
Assistant Professor of Pediatrics - Children’s Hospital of Orange County, Orange, CA
2009 – 2012
Ellen Plummer 1 in preparation - Physician – Rogue Valley Medical Center, Medford, OR
2009 – Carrie Laborde 2 - Physician - St Vincent
10
2012 HealthcareFortin Specialty Clinic, Billings, MT
2008-2011 Carrye Cost 1 1.Selected for platform presentation at annual fellows research day
2.Call for Cash, Children’s Cancer Fund of Dallas
3.Children’s Cancer fund of Dallas Research fellow
Assistant Professor of Pediatrics, Cincinnati Children’s Hospital Medical Center
2008 – 2011
Amy Fowler 0 1.Best research poster award at annual fellows research day
Physician - Austin Regional Clinic, Austin, TX
2008 – 2011
Nicholas Fustino 4 - Physician - Coventry Health Care of Iowa
2007 – 2010
Amanda Blair 1 - Faculty – UT Health Sciences Center, San Antonio, TX
2007 – 2010
Hanumantha Pokala
1 - Faculty – University of Oklahoma
2007 – 2010
Puja Gupta 1 1.Amgen Oncology Institute Hem/Onc Fellowship Award
Faculty – University of Arizona
2006 – 2010
Mark Hatley 1 1.Pediatric Scientist Dev. Prog Fellow, NIH/NICHD
2.Children’s Cancer Fund Res. Grant, MicroRNA-21 & Tumorigenesis
Instructor - UTSW
2006 – 2009
Cristina Tarango 1 1.Physician Scientist Training Program (PSTP)
2.Children’s Medical Center Clinical Research Advisory Committee (CCRAC)
Instructor - UTSW
2006 – 2009
Martha Stegner 0 - Asst Professor - UTSW
2006 – 2009
Tim McCavit 2 NHLBI Sickle Cell Scholar Asst Professor - UTSW
2005 – 2008
Alison Niece 1 Amgen Oncology Institute Hem/Onc Fellowship Award
Asst Professor -Children’s Mercy Hospital,Kansas City, MO
2005 – 2008
Laura Klesse 0 Children’s Brain Tumor Foundation (CBTF)
Asst Professor - UTSW
2005 – 2008
Jason Litten 5 1. St. Baldrick’s Foundation Senior Medical Scientist - Amgen-Oncology , Thousand Oaks, CA
2004 – 2007
Tamra Slone 1 1. ASCO/AACR Young Investigator award
2. ASH - CRTI
Asst Professor - UTSW
2004 – 2007
Cindy Neunert 4 1. ASH - CRTI Asst Professor - UTSW
2004 – 2007
Jennifer Wright 0 - Asst Professor -University of Utah School of MedicineSalt Lake City, UT
2003 – 2006
Jonathan Wickiser 1 1. Amgen Oncology Institute Hem/Onc Fellowship Award
2. ASCO Young Investigator Award
3. American Association of Cancer Research Fellowship
Asst Professor - UTSW
11
Award2003 – 2006
Shelley Crary 2 1. Amgen Oncology Institute Hem/Onc Fellowship Award
2. Hemophilia and Thrombosis Research Society
3. ASH - CRTI
Asst Instructor - UTSW
2002 – 2005
Brian Cauff 1 - Staff - Joe DiMaggio Children’s HospitalHollywood, FL
2002 – 2005
LaJuan Jones 0 - Assistant Professor -University of Missouri-Columbia, Columbia, MO
2002 – 2005
Jennifer Cox 0 - Asst Professor - UTSW
Current Fellows:Graduation Year
Fellow Scholarship focus # presentations
at national meetings
# Publications during fellowship +/or subsequent to
fellowship research**
Grants/Awards
2013 Kasey Leger Micro-RNA’s and anthracycline induced cardiac toxicity
- - 1. ASCO Young Investigator Award
2. AACR / ASCO sponsored Clinical Cancer Research workshop
2013 Kenneth Chen Molecular biology of germ cell tumors
1 (9/12) 1 Cancer Center T32
2013 Wilson File Education 2 1 under review Children’s Cancer Research Fund
2013 Rachel Thienprayoon
Palliative care, end of life care for children with cancer
1 (8/12) - 1. St. Baldrick’s Foundation
2. ASH’s CRTI2014 Sara Helmig MAP kinase in pediatric
cancer- - -
2014 Priya Mahajan Rhabdomyosarcoma and EGFR expression
- - -
2014 Ajla Wasti Cellular metabolism and pediatric cancer
- - -
2015 Shannon Cohn - - - -2015 Jacquelyn Powers - - - -2015 Kathleen Wiertel - - - -2015 Natalie Pounds - - - -
**67 total manuscripts have been published throughout the careers of all fellows listed above.
Invited Lectures
Year(s) Title LocationNational2012 Ewing Sarcoma – are we there yet? University of Iowa, Iowa City, IA2011 Alternative pathways in fellowship training and
education – educator pathways;American Society of Hematology Annual meeting, San Diego, CA
12
2011 New Approaches to relapsed Ewing Sarcoma University of Chicago, Chicago, IL2011 New Approaches to relapsed Ewing Sarcoma Medical College of Wisconsin and Children’s
Hospital of Wisconsin, Milwaukee, WI2010 Successful Recruitment American Society of Hematology annual
meeting, Orlando, FL2010 New Approaches to Relapsed Ewing Sarcoma City of Hope, Duarte, CA2009 New Approaches to Relapsed Ewing Sarcoma Advances in the Diagnosis and Management of
Ewing Sarcoma;3nd Semi-Annual Musculoskeletal Tumor Symposium;Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Regional/Local2012 Pediatric Bone and Soft Tissue Sarcoma – the
interdisciplinary teamPhysical Medicine and Rehabilitation Lecture series Children’s Medical Center Dallas
2012 Graduate Medical Changes – are we there yet? Pediatric Hematology/Oncology Grand Rounds – Children’s Medical Center Dallas
2010 Bone Sarcoma – Role of the Interdisciplinary team
School of Health ProfessionsGrand Rounds
2009 Recurrent Ewing Sarcoma Pediatric Hematology/Oncology Grand Rounds – Children’s Medical Center Dallas
2009 Rubor, Calor, Dolar and Tumor … When to call a pediatric oncologist.
Practical Pediatric Hematology Oncology / Legacy Children’s Medical Center, Plano, TX
2009 Bone Sarcoma Hematology Oncology Fellowship conference (Internal Medicine) - UT Southwestern
2009 Non-rhabdomyosarcoma Soft Tissue Sarcoma Hematology Oncology Fellowship conference (Internal Medicine) - UT Southwestern
Service to the Community
Year(s) Role Organization or institution1999 – present Chair, Program Committee
Member, Board of DirectorsMember, Advisory Board
Clayton Dabney Foundation for Kids with Cancer
2011 – present Medical Advisory Board Team Connor Foundation2008 – present Medical Advisory Board Children’s Cancer Fund Dallas2006-2008 Medical Advisory Board Curing Kids Cancer
Bibliography
Original Research Articles
1. O'Sullivan JJ, Leavey P, Mulcahy R. Inappropriate long-term medication in patients admitted to a coronary care unit. J R Coll Physicians Lond 1989; 23:232-235.
2. Leavey P, Varughese M, Breatnach F, O'Meara A. Langerhans cell histiocytosis--a 31 year review. Ir J Med Sci 1991; 160:271-274
13
3. Varughese M, Leavey P, Smith P, Sneath R, Breatnach F, O'Meara A. Osteogenic sarcoma and Rothmund Thomson syndrome. J Cancer Res Clin Oncol 1992; 118:389-390
4. Leavey PJ, Odom LF, Poole M, McNeely L, Tyson RW, Haase GM. Intra-operative radiation therapy in pediatric neuroblastoma. Med Pediatr Oncol 1997; 28:424-428
5. Leavey PJ, Thurman G, Gonzalez-Aller C, Zerbe G, Ambruso DR. The effects of stem cell factor and granulocyte colony stimulating factor therapy on the activity of the neutrophil NADPH oxidase enzyme system. J Investig Med 1998; 46:121-126
6. Leavey P.J., Sellins K.S., Thurman G., Elzi D., Hiester A., Silliman C.C., Zerbe G., Cohen J.J., Ambruso D.R. In vivo treatment with granulocyte colony-stimulating factor results in divergent effects on neutrophil functions measured in vitro. Blood 1998; 92:4366-4374
7. Leavey PJ, Thurman G, Ambruso DR. Functional characteristics of neutrophils collected and stored after administration of G-CSF. Transfusion 2000; 40:414-419
8. Mantadakis E, Herrera L, Leavey PJ, Bash RO, Winick NJ, Kamen BA. Fractionated cyclophosphamide and etoposide for children with advanced or refractory solid tumors: a phase II window study. J Clin Oncol 2000; 18:2576-2581
9. Mantadakis E, Kim G, Reisch J McHard, K., Maale, G., Leavey, P.J. and Timmons, C. Lack of prognostic significance of intratumoral angiogenesis in nonmetastatic osteosarcoma. J Pediatr Hematol Oncol 2001; 23:286-289
10. Leavey PJ, Mantadakis E, Maale G. Variability in dose intensity of high-dose methotrexate for nonmetastatic osteosarcoma. Pediatr Hematol Oncol 2002; 19:483-489
11. Leavey,P.J., Gonzalez-Aller, C., Thurman,G., Kleinberg,M., Rinckel,L., Ambruso,D.W., Freeman,S., Kuypers,F.A. and Ambruso,D.R. A 29-kDa protein associated with p67phox expresses both peroxiredoxin and phospholipase A2 activity and enhances superoxide anion production by a cell-free system of NADPH oxidase activity. J Biol Chem 2002; 277:45181-45187
12. Saland JM, Leavey PJ, Bash RO, Hansch E, Arbus GS, Quigley R. Effective removal of methotrexate by high-flux hemodialysis. Pediatr Nephrol 2002; 17:825-829
13. Zimbelman J, Thurman G, Leavey PJ, Ellison MC, Ambruso DR. In vivo treatment with granulocyte colony-stimulating factor does not delay apoptosis in human neutrophils by increasing the expression of the vacuolar proton ATPase. J Investig Med 2002; 50:33-37
14. Dickens DS, Kozielski R, Leavey PJ, Timmons C, Cripe TP. Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma. J Pediatr Hematol Oncol 2003; 25:282-285
15. Leavey PJ, Day MD, Booth T, Maale G. Skip metastasis in osteosarcoma. J Pediatr Hematol Oncol 2003; 25:806-808
16. Ye D, Maitra A, Timmons CF, Leavey PJ, Ashfaq R, Ilaria RL, Jr. The epidermal growth factor receptor HER2 is not a major therapeutic target in Ewing sarcoma. J Pediatr Hematol Oncol 2003; 25:459-466
17. Bowers DC, Aquino VM, Leavey PJ, Bash RO, Journeycake JM, Tomlinson G, Mulne AF, Haynes HJ, Winick NJ. Phase I study of oral cyclophosphamide and oral topotecan for children with recurrent or refractory solid tumors. Pediatr Blood Cancer 2004; 42:93-98
18. Leavey PJ, Timmons C, Frawley W, Lombardi D and Ashfaq R. KAI-1 expression in pediatric high grade osteosarcoma. Pediatr Dev Pathol 2006; 9:219-224
19. Portteus A, Ahmad N, Tobey D and Leavey P. The Prevalence and Use of Anti-depressant Medication (ADM) in Pediatric Cancer Patients. J Child Adolesc Psychopharmacol 2006; 16(4):467-473
20. Wickiser JE, Thompson M, Leavey PJ, Quinn CT, Garcia NM and AquinoVM. Extracorporeal Membrane Oxygenation (ECMO) Initiation without Intubation in Two Children with Mediastinal Malignanc. Pediatr Blood Cancer 2007; 49(5):751-754
21. Leavey PJ, Mascarenhas L, Marina N, Chen Z, Krailo M, Miser J, Brown K, Tarbell N, Bernstein
14
ML, Granowetter L, Gebhardt M and Grier HE. Prognostic Factors for Patients with Ewing sarcoma (EWS) at First Recurrence Following Multi-modality Therapy – A report from the Children’s Oncology Group. Pediatr Blood Cancer. 2008 Sep;51(3):334-8
22. Granowetter L, Womer R, Devidas M, Krailo M, Wang C, Bernstein M, Neyssa M, Leavey P, Gebhardt M, Healey J, Shamberger RC, Goorin A, Miser J, Meyer J, Arndt C, Sailer S, Marcus KJ, Perlman E, Dickman PS and Grier H. Comparison of dose intensified versus standard chemotherapy for non-metastatic Ewing Sarcoma Family of Tumors (ESFT): A Children’s Oncology Group Study Report. J Clin Oncol. 2009; 27(15):2536-41
23. Victor M Aquino VM, Cost C, Gomez A, Bowers DC, Ramilo O, Ahmad N, Winick N, Leavey PJ. Predictive value of interleukin-5 and monocyte chemotactic protein-1 (MCP-1) for bactermia in children with febrile neutropenia. J Pediatr Hematology/ Oncology, 2012 (Epub ahead of print)
24. Cost C, Stegner MM, Leonard D and Leavey P. IL-8 predicts pediatric oncology patients with febrile neutropenia at low-risk for bacteremia. J Pediatr Hematol/Oncol, 2013 (in press).
Reviews, Chapters, Monographs and Editorials
1. Leavey PJ and Collier AB. Ewing sarcoma: prognostic criteria, outcomes and future treatment. Expert Rev Anticancer Ther. 2008 Apr;8(4):617-24
2. Leavey, P.J. and Jubran, R.F. Graduate Medical Changes: Yes We Can or Enough Already? Pediatr Blood Cancer, 2012 (Epub ahead of print April 2012)
3. Leavey, P.J. How many physicians do we need? A Benchmark for Pediatric Hematology/Oncology Pediatr Blood and Cancer, 2012 (in print)
Case Reports
1. Day M, Edwards AO, Weinberg A, Leavey PJ. Brief report: successful therapy of a patient with infantile generalized myofibromatosis. Med Pediatr Oncol 2002; 38:371-373
Non-peer reviewed scientific or medical publications/materials in print or other media
1. Leavey, P.J., Cummings, D., Maale, G. Pediatric Bone Tumors: A Multidisciplinary Perspective Dallas Med J (2000) 86(10):420-424
15
