XIX WORLD CONGRESS OF THE ISHR - iec-srl.it · the XIX World Congress of the ISHR will transmit a ... globalization it is still important to be part of a ... Carpigiani, Culligan,

Including the Annual Meetings of the Australasian,European, Japanese and North American Sections

Final Program

www.ishr-italy2007.org

XIX WORLD CONGRESS OF THE ISHR

Bologna, Italy 22 - 25 June 2007

FROM CELL TO MAN TO SOCIETY

CONTENTS P.5 P.7 P.13 P.21

Welcome address Making it all possible

• Participating organizations

• Sponsoring corporations

• The ISHR• The Bologna World

Congress workforce

Finding your wayaround Bologna and atthe Congress Center

• How to find your hotel• How to get around

Bologna• General layout• Ground floor• First floor• Palazzo Affari and

Holiday Inn• Services and facilities

The serious science

• The congress at a glance• ISHR Council Meetings• How to present your posters• June 22: detailed program• June 23: detailed program• June 24: detailed program• June 25: detailed program

P.121 P.123 P.124 P.127

The answers to those questions • General information

The trade exhibition

• Exhibiting area and exhibitors list

Arrivederci: the White Evening

Index

• List of Chairpersons, Speakers and Authors

Dear Colleagues,

4

Welcome to Bologna 2007. You are attending a congressheld in the oldest university in the world. It datesback to 1088, when teaching and research in“Bononia” became free and independent from ecclesiastic schools. The very concept of a university:a place where a scholar carries out research for thesake of knowledge and transmits this knowledge to agroup of pupils. Obviously things have changed since then, but the concept remains the same, and we are confident thatthe XIX World Congress of the ISHR will transmit agreat deal of knowledge to all of us. Bologna 2007 is bigger than we dared: almost 2000 delegates and guests, 5 Plenary sessions, 56 Frontiersymposia, 4 Nobel Laureates and landmark scientificevening lectures, and 700 posters. We make no apologyfor introducing much more clinical material into theprogram, our idea From Cell to Man to Society canonly progress when laboratory and clinical scientistsbuild bridges to interact and communicate. Our major symposia bear the names of sponsoring organizations – many of which are commercial companies. We are proud of this – and grateful – asnot only has this helped enormously with the financialchallenge of the Congress, but it has also helped tobridge the divide between the science of “academia”and that of the “drug companies”. Several achievements of cardiovascular pharmacologyare saluted at this meeting, without a single product-related symposium.

Our Scientific Program Committee has been completelyindependent from our sponsors as would be expectedby the outstanding and distinguished faculty of speakers. Our sponsors have in no way tried toinfluence the scientific content of the symposia andfor this we are grateful to them. A cultural and social program will compliment thisfeast of science and we hope you will enjoy it to thefullest. But Bologna 2007 is not only the congress of theWorld Section, it includes the Annual Meetings of theAustralasian, European, Japanese and NorthAmerican Sections, which were hosted in equally prestigious universities in Italy, those of Padua (thefirst faculty of medicine in the world!), Ferrara (theuniversity of Copernicus and Paracelsus) andBologna itself. We are particularly pleased to haveachieved this: in the era of modernization and globalization it is still important to be part of ahuman fraternity and to enjoy meeting each other.

To all of these Sections, our greatest thanks.

We look forward to welcoming you to Bologna

Ciao

5A message from the organizers

Roberto Ferrari Luigi Tavazzi

6

WHO TO CONTACT AND WHERE TO GO

SCIENTIFIC SESSIONSPalazzo della Cultura e dei Congressi di BolognaPiazza Costituzione 440128 Bologna - Italyphone: +39 051 63.75.111fax: +39 051 63.75.170

OPENING CEREMONY AND EVENING LECTURESAula Magna Santa LuciaAlma Mater Studiorum University of BolognaVia Castiglione, 3640124 Bologna – Italyphone: +39 051 63.75.111fax: +39 051 63.75.170

ORGANISING SECRETARIATI&C s.r.l. Via A. Costa 2 40134 Bologna - Italy phone: +39 051 61.44.004fax: +39 051 61.42.772 e-mail: [email protected]

HOTEL AND TRAVEL INFOG.T. 97 GARDEN TRAVEL srl Via Flaminia 19600196 Rome - ItalyContact Person: Laura Vivaldaphone:+39 06 32.82.025fax: +39 06 32.45.047 e-mail: [email protected]

WEB SITE ADMINISTRATORN-ware Software & Servicese-mail: [email protected]

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MAKING IT ALL POSSIBLE

Organising a World Congress requires a little insanity and alot of help from friends, colleagues, academic institutions,and generous sponsors without whom nothing would be possible.

There are thousands of people to be thanked, but a specialand heartfelt thanks goes to Metin Avkiran, ElizabethMurphy and Jim Willerson for their continuous assistance.

8

PARTICIPATING ORGANIZATIONS

The ISHR thanks the following organizations for their scientific,cultural and/or financial support:

ASCOM BolognaAustralasian Section of the ISHRCassa di Risparmio di Ferrara European Section of the ISHRFondazione Cassa di Risparmio in BolognaFondazione Cassa di Risparmio di CentoFondazione del Monte di Bologna e RavennaFederazione Italiana di Cardiologia Fondazione Luisa Fanti Melloni Fondazione Salvatore Maugeri Fondazione Villa Maria Cecilia Japanese Section of the ISHRMedical Trials Analysis Municipality of BolognaMunicipality of Ferrara North American Section of the ISHRProvincia di Ferrara Alma Mater Studiorum - University of BolognaUniversità degli Studi di FerraraUniversità degli Studi di PadovaUniversità degli Studi di Pavia

MT

The ISHR thanks the following organizations for their financialsupport in the form of unrestricted grants:

9

SPONSORING CORPORATIONS

AstraZenecaPfizer

Servier

A. Menarini

Menarini International

Merck Sharp & Dohme

Sigma-Tau

Abbott

CV Therapeutics

GE Healthcare

Novartis

Schering Plough

Boehringer Ingelheim

Chiesi

I.F.B. Stroder

Siemens

Takeda Italia Farmaceutici

and...Acetaia Malpighi, Bio Suedtirol, Carpigiani, Culligan,

Hombre, Valsoia

and...ADInstruments, Gardhen Bilance, Gilead Colorado,Recordati, Red Box Direct, Scisense, VisualSonics

PLATINUM GOLD

SILVER BRONZE

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THE ISHR

Officers of ISHR International

President: R Ferrari

Past President: J Downey

President Elect: R Bolli

Secretary General:M Avkiran

Treasurer:E Murphy

JMCC Editor: R Walsh

Heart News &Views Editor: T Ruigrok

Council ofISHR International

Council: D BersLM DelbridgeF Di Lisa S DimmelerDA EisnerNK Ganguly G HasenfussG Heusch T HintzeM Hiraoka M Hori I KomuroE MarbánRL MossR Nagai E Olson S PepeP Tucci RP Xiao

Honorary LifePresident:RJ Bing

Officers andCouncil of theAustralasian ISHR

President:S Pepe

Secretary:LM Delbridge

Treasurer:X-J Du

Newsletter,Website & HeartNews & ViewsEditorial Board:H Kiriazis

Council members:D AllenM BogeyevitchJ HeadrickL HoolTM WongD SaintB SmailF SupariI Wendt

Officers and Council of the European ISHR

President:F Di Lisa

President Elect:S Harding

Past President:G Heusch

Secretary:GF Baxter

Council Members:S ChlopickiD EisnerT EschenhagenP FerdinandyM FlugelmanD Garcia-DoradoT LarsenC van EchteldR Ventura-Clapier

Officers andCouncil of theJapanese ISHR

President:M Hori

President Elect:I Komuro

Past President:M Hiraoka

Secretary General:M Kurabayashi

Treasurer:T Izumi

Council members:H Fujiwara K Fukuda H Hayashi M Hori M Isobe T IzumiM Kitakaze I Kodama I Komuro M Kurabayashi Y Kurachi S Kurihara M Matsuzaki R Nagai H NakayaY SaitoY Sawa N Takeda T ToyookaH Tsutsui

Officers andCouncil of theNorth American

President:RL Moss

President Elect:DM Bers

Past President:WB Weglicki

Secretary:E Murphy

Treasurer:E Kranias

Council members2003-2009: JH BrownL Field L KirschenbaumD LewandowskiB LondonJ MolkentinG TomaselliJ Van EykF Villareal

2006-2012:P BackxM BondP PingP SimpsonS SteinbergJ SolaroR Tian

The International Societyfor Heart Research

The Society was founded in1968 to provide a forum forthe exchange of ideas betweenlaboratory and clinical researchers with an interest incardiovascular biology andmedicine. The Society has sevenSections, each holding anannual meeting, and every 3 years all Sections cometogether for a WorldCongress. For the first timeever the Australasian,European, Japanese andNorth American Sections willhold their annual meeting inconjunction with the WorldCongress the day before. The Journal of Molecular andCellular Cardiology is theofficial Journal of the Society,and is available to membersat a concessionary rate.

The seven Sections of the ISHR

Australasian ChineseEuropean Indian JapaneseLatin American North American

ISHR

11

Organizers of Bologna 2007

Roberto Ferrari Luigi Tavazzi

We would like to expressour thanks to the members of the followingCommittees who played an important part in the realization of Bologna 2007.

North American SectionBologna

A BranziCM Caldarera C Guarnieri C Rapezzi

International ScientificProgram AdvisoryCommittee

JT Willerson - ChairM Avkiran - Chair P AnversaR Bolli F Di LisaR FerrariG Heusch M HiraokaM HoriI Komuro E LakattaRL MossE Olson L Tavazzi

European SectionPadua

F Di LisaS Iliceto P Schiaffino G Thiene

Cultural ProgramCommittee

A Branzi C FlorioF Roversi MonacoA SantiniD Sala

Japanese SectionFerrara

CA Beltrami F Bernardi C Ceconi R Ferrari

Action Committee

L Anderson LobaughR BagnaiaN CaniatoC CasaliC CeconiT KrookS Di LorenzoMR MorgantiS ParolariA RondinellaD SalaF SchiassiP SteffeniniV SteffeniniA TinarelliJ VerriL Vivalda

Satellite SectionPavia

L Tavazzi PJ SchwartzE ArbustiniU Kuhl

International and NationalSponsorship Committee

R BagnaiaA BologniniR FerrariS GolceaS IlicetoF MastrolilliB MerliniC RapezziD SalaL TavazziG Thiene

International SectionBologna

M Avkiran R FerrariE MurphyL Tavazzi

THE BOLOGNA WORLD CONGRESS WORKFORCE

THE LOCAL SECTIONS CONGRESS WORKFORCE

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FINDING YOUR WAY AROUND BOLOGNAAND AT THE CONGRESS CENTER

Bologna is famous for its arcades that date back to the originof the University. At that time students were different from now… Indeed theytravelled to Bologna from all over Europe with servants,chefs, stable men etc. The population of the city increased tothe extent that it became necessary to build an extension, supported by pillars, to the already existing “student” palaces(a typical example of this can be seen in Strada Maggiore 8).These arcades were then kept for convenience. Please enjoy awalk under them. If it rains you will not need an umbrella…if the sun is shining you will be protected.

The Bologna Convention Center has a simple layout and ourlecture rooms are color-coded in the program.

The evening lectures will take place in the historical churchof Santa Lucia in the center of Bologna. On the first eveninga bus transfer will be provided. The following evenings youwill have to walk!

To find food, wine and traditional Italian shopping, use yourinstinct.

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PALAZZO DEI CONGRESSI

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HOW TO GET AROUND BOLOGNAHOW TO FIND YOUR HOTEL

1 AL CAPPELLO ROSSO 2 COMMERCIANTI HOTEL 3 CORONA D'ORO HOTEL 4 DONATELLO HOTEL5 DUE TORRI HOTEL 6 FIERA HOTEL 7 GRAND HOTEL BAGLIONI 8 HOLIDAY INN BOLOGNA CITY 9 INTERNAZIONALE HOTEL10 JOLLY HOTEL DE LA GARE 11 NOVECENTO HOTEL 12 NUOVO HOTEL DEL PORTO 13 PALACE HOTEL14 PORTA SAN MAMOLO HOTEL 15 ROMA HOTEL 16 ROYAL HOTEL CARLTON 17 SAVHOTEL 18 STARHOTEL EXCELSIOR 19 UNAHOTEL

FROM THE AIRPORT TO THE CITY CENTER:By taxi: approximately 30 min - e 30.00

By bus: “AEROBUS” every 30 min - e 5.00

FROM THE STATION TO THE CITY CENTER:By taxi: approximately 5 min - e 18.00

By bus: bus lines A/C/E/D

FROM THE CITY CENTER TO THE CONGRESS CENTER:By bus: buses no. 28/10/35/38

FROM THE CONGRESS CENTER TO S. LUCIA:By taxi: approximately 20 min - e 20.00

By bus: bus no. 38 (“Porta Castiglione” suggested bus stop)

FOR A TAXI, PLEASE CALL ONE OF THE FOLLOWING NUMBERS:- 0039 051 372727

- 0039 051 372525

- 0039 051 534141

As for your bus ticket, do not worry. It will be provided as a courtesy ofthe Congress Organization.

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GENERAL LAYOUT OF THE CONGRESS CENTER

HOLIDAY INNBOLOGNA CITY CONGRESS

CENTER

PALAZZOAFFARI

PARKING AREAFOR A FEE

PIAZZACOSTITUZIONE

MAINENTRANCE

EXHIBITORSENTRANCE

Via Calzoni

Exhibition AreaHall Europa

Hall ItaliaHall RossaHall Verde

FIRSTFLOOR

GROUNDFLOOR

Exhibition AreaReception

PC and Business CenterCloakroom

Press OfficeISHR Secretariat

Hall TopazioHall AcquarioHall Sagittario

SpeakersRegistration

Food CourtPoster Area A

Food CourtPoster Area B

Hall AzzurraHall Bianca

EXHIBITORSPARKING

AREA

GROUND FLOOR

EXHIBITION AREA

TO POSTERSAND FOODCOURT B

PRESSROOM

RECEPTION ANDREGISTRATION

BA

R

MA

IN E

NT

RA

NC

ETO POSTERSAND FOODCOURT A

PLATINUM SPONSORSMEETING POINT

The brick of Venice:an exhibition of Peter Harris’ watercolours

SPEAKERS REGISTRATION

PC AND BUSINESS CENTER

ISHR CONGRESSROOM

ISHR SECRETARIAT

17

18

FIRST FLOOR

HALL VERDE

HALL ROSSA

HALL ITALIA

HALL EUROPA

SLIDECENTER

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PALAZZO AFFARI AND HOLIDAY INN

HALL BIANCA

HALL AZZURRA

FROM DOWNSTAIRS

HALL TOPAZIO

HALL SAGITTARIOBAR

HALL ACQUARIO

ISHR COUNCILMEETINGS

PALAZZO AFFARI

HOLIDAY INN

ground floor

first floor

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HOW TO GET AROUND THE CONGRESS CENTER: SERVICES AND FACILITIES

CERTIFICATION OF ATTENDANCECertificates of Attendance will be available on request at theend of the Congress.

ITALIAN CME CREDITSThe Congress has obtained 16 Italian CME credits by the Ministryof Health.

LANGUAGEEnglish is the official language. No simultaneous translation willbe provided.

SLIDE CENTERFor Halls Italia, Europa, Verde and Rossa, the Slide Center islocated on the same floor as the Halls (1st floor) and it is connectedto all four rooms via LAN. For all other Halls, the slide center islocated at the rear of the Hall itself. All speakers are kindly invi-ted to deliver their presentations to the Slide Center at least onehour before their intervention.

CAFETERIAAlthough free coffee is always available, the bar at the CongressCenter provides the real stuff for a small charge. You can orderan espresso, corto, lungo, macchiato, marocchino, montebianco,cappuccino, latte macchiato, caffè macchiato, corretto, etc. …and hopefully you will be understood.

FOODLunch will be served in the two poster areas. The idea is to let yousample the many different pasta varieties. Although you’re inItaly, no alcohol will be served at lunch: a tribute to science.

DISABLED PEOPLEThe building is fully accessible to disabled people.

LEFT-LUGGAGE AND CLOAKROOMLeft-luggage and cloakroom are available in the Congress Venue.

PC AND BUSINESS CENTERA business lounge, with access to the Internet, PCs and printers,is available and free of charge to all.

BANKCash machines only.

VISUAL REPRODUCTIONPhotographing or filming sessions or meetings is prohibitedon the Congress and exhibition premises.

NO SMOKINGSmoking is prohibited in all areas of the Congress Center.

REGISTRATIONThe registration desk will be open on: Friday, June 22 - from 12:00 to 19:00. From Saturday, June 23, to Monday, June 25 - from 7:00 to 20:00.

BADGESThe official badge must be worn in the congress area. No badge, noentrance. You better not lose your badge as we will charge you for anew one… We will also need a proof of the original registration.

FINAL PROGRAM AND ABSTRACT BOOKAdditional Final Programs and Abstract Books can be purchased forE 20.00 each.

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THE SERIOUS SCIENCE

In Bologna, for the first time ever, the ISHR International joinsthe Australasian, European, Japanese and North AmericanSections, which held their annual meetings in Padua, Ferraraand Bologna respectively. The World Congress offers you over60 symposia, 5 plenary sessions, 56 frontier symposia, almost700 posters, and a great deal of time for informal interaction.

Further to this, at Santa Lucia every evening, you and yourpartner will also have the opportunity to attend Nobel Laureateor landmark scientific lectures as well as cultural lectures. Wehope you will enjoy the Congress as much as we have enjoyedconceiving it.

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THE CONGRESS AT A GLANCE

Friday June 22, 2007

Hall Azzurra Hall Bianca Hall Sagittario Hall Topazio Hall Verde Hall Rossa Hall Italia Hall Europa

Peter Harris Distinguished Scientist AwardDavid Hearse (UK): "Ischemia, reperfusion and cardioprotection: successes and failures in the journey from laboratory to man"15.30-16.30

Frontier symposiumMatrix metallopro-

teinases in the ischemic and failing

heart

Frontier symposiumConnexin-43 in cardiovascular

disease

Frontier symposiumCardiac protein oxidation: from

damage to redoxsignaling

Frontier symposiumNADPH oxidases in

cardiovascular signaling and disease

Frontier symposiumViability versus

necrosis: new insights

Frontier symposiumStatins treatment:

beyond lipid loweringachievement

16.30-18.00

Transfer by bus to Hall Santa Lucia18.00-19.15

Nobel Laureate Lecture: Louis J Ignarro (USA): "Nitric oxide as a unique signaling molecule in the cardiovascular system"

Cultural Lecture: Philippe Daverio (IT): "Such a wonderful contemporary old place. Talking about Bologna"

Incoming President's Address Roberto Bolli (USA)

19.30-20.15

20.15-20.45

Followed by a "Pasta" dinner

Palazzo dei Congressi

20.45-21.00

Holiday Inn

"Welcome to Bologna" Roberto Ferrari (IT), Luigi Tavazzi (IT)19.15-19.30

Hall Santa Lucia

Saturday June 23, 2007


Landmark Scientific Lecture: Eric Olson (USA): "Toward a molecular blueprint of heart development and disease"

Cultural Lecture: Anna Ottani Cavina (IT): "Discovering Bologna. The secret charme of a city"

20.00-20.45

20.45-21.15

11.00-12.30

Frontier symposiumRebuilding the cardiac vessels

Frontier symposiumCardiovascular regeneration:

embryonic versusadult stem cells

Frontier symposiumAngiotensin - growth

and functionalmodeling

in the heart

Frontier symposiumNew understandingand treatments inatrial fibrillation

Frontier symposiumSpatial organization

of signaling pathways in cardiac

myocytes

Frontier symposiumFrom bench to

bedside: the challengeof managing

acute thrombosis

17.00-18.30

Frontier symposiumAldosterone and

heart failure

Frontier symposiumBiomarkers and

inflammation

Research Achievement Award: Martin J Lohse (DE): "Finding targets for heart failure therapy"14.00-15.00

Plenary session The complexity of device therapy 15.00-16.30

Frontier symposiumRevisiting the role of

Ins(1,4,5)P3 in myocardium

Frontier symposiumCarotid artery

disease: addressing therapeutic options

Frontier symposiumBasic biology of cell division and differentiation

Frontier sysmposiumRole of reactive

oxygen species (ROS)in myocardial physio-

logy and pathology

Frontier symposiumCholesterol: are statins enough?

Frontier symposiumZ-disc and M-bandproteins and theirimplications for

human heart disease

Poster mounting8 .00 -9 .00

Coffee-break10.30-11.00

12.30-14.00 Lunch symposium Recent developments on the role of ARBs in protecting the heart and the brain and Moderated posters with lunch


Free time and walk to Hall Santa Lucia 18.30-20.00

Palazzo dei Congressi Holiday Inn

Free evening

Frontier symposiumEndothelial dysfun-

ction in hypertensionand heart failure:

from bench to bedside

Plenary session The complexity of the heart beat

Frontier symposiumThe Iƒ current:

a new therapeutictarget

9.00-10.30

Hall Santa Lucia

Poster mounting

Sunday June 24, 2007


12.30-14.00

8.00-9.00

11.00-12.30

Frontier symposiumA road map for cardiogenesis

Richard J.BingAward for Young

Investigators

Frontier symposiumHeart rhythm and

arrhythmias

Frontier symposiumHeart failure: what

have we understood so far?

Frontier symposiumRole of reactive

oxygen species inthe control of coro-

nary blood flow

17.00-18.30Frontier symposiumRole of the angioten-sin II AT2 receptors

in cardiovascular disease

Frontier symposiumHow best to controlCV risk in diabetes

patients



Frontier symposiumUpdate on SCD

prevention in dilated

cardiomyopathy

Frontier symposiumPotential gene

therapy targets in cardiovascular disease


Keith Reimer Distinguished Lecture: Eduardo Marbàn (USA): "Stem cells for cardiac regeneration"14.00-15.00

Plenary session The complexity of diabetes15.00-16.30

Frontier symposiumSignaling

mechanisms regulating apoptosis

Landmark Scientific Lecture: Salim Yusuf (CA): "Cardiovascular diseases: a maladaptation to societal progress?" 20.00-20.45

Frontier symposiumPKD signaling:

alphabetical progres-sion or fundamental

progress?

Frontier symposiumTranslating the rege-nerative potential:focus on ischemiaand angiogenesis

Frontier symposiumNutritional strategiesto prevent cardiova-

scular disease: a current review


Lunch symposium The heart of the matter: a career in cardiovascular research and Moderated posters with lunch

Frontier symposiumACE inhibition: stilla long way to go fora full understanding

Frontier symposiumTrials and

tribulations of p38-MAPK

Lunch Lecture JIKEI HEART STUDY - Results and relevance in context of existing morbi-mortality data and Moderated posters with lunch

Plenary session The complexity of the metabolic syndrome

Frontier symposiumManaging the

metabolic syndrome:a multifactorial

approach

ISHR fellows dinner

Hall Santa Lucia

9.00-10.30

Poster mounting

Monday June 25, 2007


12.30-14.00

8 . 00 -9 .00

11.00-12.30

Frontier symposiumCalcium dysregula-tion and therapeutic

manipulation in heart failure

Frontier symposiumMetabolic aspects of CAD and CHF

Frontier symposiumProstanoid pathways in

atherosclerosis

Frontier symposiumRemodeling, theheart returns to

childhood

Frontier symposiumPharmacogenetics:

impact of adrenoceptor

polymorphisms

17.00-18.30Frontier symposiumStatins and cardiova-scular disease: oddi-ties and unexpected

findings

Frontier symposiumFrom ischemia tolethal arrhythmia

Frontier symposiumHow to optimizecardiac energymetabolism?

Frontier symposiumNew paradigms in G

protein-coupled receptor signaling

Frontier symposiumInjury and

protection duringmyocardial ischemia

and reperfusion


Janice Pfeffer Distinguished Lecture: Joanne Ingwall (USA): "Energetics of the failing heart: new tools yield new insights"14.00-14.45

President's Distinguished Lecture: Jeffrey Robbins (USA): "Genetic manipulation of the mammalian heart: what have we learned?"15.45-16.30

ISHR General Assembly14.45-15.45

Frontier symposiumNew insights into plaque vulnerabi-

lity


HALL EUROPA Nobel Laureate Lecture: Aaron Ciechanover (IL): "The ubiquitin proteolytic system: from basic mechanisms and onto human diseases and drug targeting"

Cultural Lecture: Massimo Montanari (IT): "The culture of food, between identity and exchange"

Followed by the "white" closing night

19.15-19.45

Frontier symposiumProtein kinases as

potential therapeutic targets

Frontier symposiumTranslating the regenerative

potential: focus onheart failure

Frontier symposiumCritical limb

ischemia: from clinical aspects to

therapeutic options


Lunch symposium Role of late (persistent) sodium current in cardiac pathophysiology and Moderated posters with lunch

Plenary session The complexity of heart failure9.00-10.30

Frontier symposiumSignposts on the multiple roads of

ageing

Frontier symposiumPotential conflictingdata relating the use

of statins in CHF

18.30-19.15

ISHR COUNCIL MEETINGS AND EXHIBITION

All Committee Meetings and the Editorial JMCC Meeting willbe held in Hall Acquario at Palazzo Affari

Council Meeting 1: Part 1, Friday, 22 June. 13.30-15.30 Part 2, Saturday, 23 June. 12.30-14.00

Council Meeting 2: Part 1, Monday, 25 June. 12.30-14.00Part 2, Monday, 25 June. 16.30-17.00 (post AGM)

ISHR Finance Committee Meeting: Sunday, 24 June. 12.30-14.00

Editorial JMCC Board Meeting: Saturday, 23 June. 7.45-9.00

ISHR General AssemblyThe General Assembly will be held on Monday, 25 June in HallEuropa at Palazzo dei Congressi from 14.45 to 15.45

ISHR Art ExhibitionPeter Harris’ watercolours “The brick of Venice” will be exhibited from Friday to Monday on the ground floor of theCongress Center

26

27

HOW TO PRESENT YOUR POSTERS

To ensure that the work described in the abstracts has the maximum exposure, all communications will be presented asModerated Posters in which the presenting author is requiredto be proactive. To ensure that your presentation is a resoun-ding success, please note the following points:

Poster mountingPosters must be mounted from 8.00 to 9.00 of the day of presentation, and will be discussed from 12.30 to 14.00 anddismounted by 18.00 of the same day. Posters not dismountedwill be removed by the Organizing Secretariat at the end of theday.

Poster discussionDuring the moderated poster sessions, the presenting authorsare required to be in attendance to describe and discuss theirworks with the Poster Moderators.

Presentation day and poster area logisticsPosters have been divided into Macroareas. Each poster has aspecific number (indicated in the detailed list of this volumeand available at the Poster Desks) corresponding to the numberof panel where it must be mounted.

Here below, you may find the subdivision of the posters byday and poster area.

DAY MACROAREAS POSTERSNO.

POSTER AREA

Electrophysiology from bench to bedside 1-63

Receptor biology and function 64-98

Intracellular signalling pathways 99-150

AREA A

Intermediate and Energetic Metabolism 151-195Genetics, Gene Biology and Molecular Biology 196-216

AREA B

Apoptosis, Cell cycle, cell growth 217-237Stem cells, cell therapy 238-276Myocardial physiology and pathophysiology 277-340

AREA A

Left Ventricular dysfunction and Heart failure 394-440

AREA B

Hypertension 341-350

Hypertrophy 351-393

Cardiomyopathies, myocarditis 441-464

Endogenous cardioprotection 465-516Ischemia and Reperfusion 517-597

AREA A

Platelets, thrombosis and coagulation 638-648AREA

BMiscellaneous 649-672

Vascular biology 598-637

Mon

day

June

, 2

5Su

nday

Jun

e, 2

4Sa

turd

ay J

une,

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PETER HARRIS DISTINGUISHED SCIENTISTAWARD

This Award recognizes lifetime scientific achievements and contributions to cardiovascular research.

David J Hearse (London, UK) 001

"Ischemia, reperfusion and cardioprotection:successes and failures in the journey from

laboratory to man"

Chair: T J C Ruigrok (Utrecht, NL)

Hall Europa Friday June 22, 2007 – 15.30-16.30 Hall Europa

ISHR Award

28

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Friday June 22, 2007 – 16.30-18.00

Frontier Symposia

Organized with an unrestricted educationalgrant from Pfizer

STATINS TREATMENT: BEYOND LIPID LOWERING ACHIEVEMENT

Chairing M Arca (Rome, IT), A Maseri (Milan, IT)

16.30 Towards cholesterol LDLideal target 002A L Catapano (Milan, IT)

16.50 Which biological markers to identifyCV risk beyond cholesterol LDL? 003C Ceconi (Ferrara, IT)

17.10 LDL and CRP target: lessons from clinical trials 004B Masri (New York, USA)

17.30 Controlling cholesterol LDL: a look to future? 005G Rosano (Rome, IT)

The Fondazione Luisa Fanti Melloni Symposium

VIABILITY VERSUS NECROSIS: NEW INSIGHTS

Chairing G Di Pasquale (Bologna, IT), W Wijns (Aalst, BE)

16.30 Therapeutic strategies in non ST-elevation acute coronary syndromes 006M Tubaro (Rome, IT)

16.50 Gender differences in early referral for non ST-elevation acute coronary syndromes 007C Risøe (Oslo, NO)

17.10 Detecting viability vs. necrosis: the role of myocardial strain 008O Smiseth (Oslo, NO)

17.30 Detecting viability vs. necrosis: the role of eco-stress 009D Mele (Ravenna, IT)

Hall Europa Hall Italia

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Friday June 22, 2007 – 16.30-18.00

Frontier Symposia

The ISHR International Symposium

NADPH OXIDASES IN CARDIOVASCULAR SIGNALING AND DISEASE

Chairing D Das (Wyandotte, USA), C Guarnieri (Bologna, IT)

16.30 Novel Nox homologues: from cytoprotection to signaling 010M Geiszt (Budapest, H)

16.50 NADPH oxidases in cardiac remodeling 011 A Shah (London, UK)

17.10 NADPH oxidases in vascular remodeling 012A Fortuño (Pamplona, ES)

17.30 Differential functions of NADPH oxidases 013R P Brandes (Frankfurt, DE)


CARDIAC PROTEIN OXIDATION: FROM DAMAGE TO REDOX SIGNALING

Chairing E Giordano (Bologna, IT), P K Singal (Winnipeg, CA)

16.30 Myofibrillar protein oxidation during cardiac oxidative stress 014M Canton (Padua, IT)

16.50 Detection and functional consequence of protein S-nitrosylation 015 S Lamas Pelaez (Madrid, ES)

17.10 Protein oxidation in the heart: from detection to functional consequences 016 P Eaton (London, UK)

17.30 A proteomic guide for biologists: focus on protein oxidation 017C E Costello (Boston, USA)

Hall Rossa Hall Verde

Friday June 22, 2007 – 16.30-18.00

Frontier Symposia


CONNEXIN-43 IN CARDIOVASCULAR DISEASE

Chairing G Caruso (Bari, IT), N J Severs (London, UK)

16.30 Expression of Cx43 in health and disease 018N J Severs (London, UK)

16.50 Regulation of Cx43 in cardiomyocytes 019E Kardami (Winnipeg, CA)

17.10 Cx43 during myocardialischemia/reperfusion 020G Heusch (Essen, DE)

17.30 Behaviour of Cx43 in congestive heart failure 021D S Rosenbaum (Cleveland, USA)


MATRIX METALLOPROTEINASES IN THE ISCHEMIC AND FAILING HEART

Chairing P J R Barton (Harefield, UK), F J Villareal (La Jolla, USA)

16.30 Matrix metalloproteinase activation in myocardial oxidative stress injury 022 R Schulz (Edmonton, CA)

16.50 Endothelial-myocyte dynamics in the failing heart: role of the extracellular matrix 023 S C Tyagi (Louisville, USA)

17.10 Targeted deletion of MMP-2 attenuates myocardial rupture and remodeling following infarction 024 A Takeshita (Fukuoka, JP)

17.30 Development of novel MMP inhibitors and characterization of cardioprotective effects 025F J Villareal (La Jolla, USA)

Hall Topazio Hall Sagittario

31

HALL SANTA LUCIA

32

Friday June 22, 2007 –19.15-21.00

Welcome to BolognaR Ferrari (Ferrara, IT), L Tavazzi (Pavia, IT)

NOBEL LAUREATE LECTURE

“Nitric oxide as a unique signaling molecule in the cardiovascular system” 026

Louis J Ignarro (Los Angeles, USA)

Chair: R Bolli (Louisville, USA)

CULTURAL LECTURE

“Such a wonderful contemporary old place. Talking about Bologna” 027

Philippe Daverio (Milan, IT)

Chair: L Tavazzi (Pavia, IT)

Incoming President’s AddressR Bolli (Louisville, USA)

Evening Lectures Evening Lectures

19.15-19.30

19.30-20.15

20.15-20.45

20.45-21.00

Saturday June 23, 2007


Landmark Scientific Lecture: Eric Olson (USA): "Toward a molecular blueprint of heart development and disease"

Cultural Lecture: Anna Ottani Cavina (IT): "Discovering Bologna. The secret charme of a city"

20.00-20.45

20.45-21.15

11.00-12.30

Frontier symposiumRebuilding the cardiac vessels

Frontier symposiumCardiovascular regeneration:

embryonic versusadult stem cells

Frontier symposiumAngiotensin - growth

and functionalmodeling

in the heart

Frontier symposiumNew understandingand treatments inatrial fibrillation

Frontier symposiumSpatial organization

of signaling pathways in cardiac

myocytes

Frontier symposiumFrom bench to

bedside: the challengeof managing

acute thrombosis

17.00-18.30

Frontier symposiumAldosterone and

heart failure

Frontier symposiumBiomarkers and

inflammation

Research Achievement Award: Martin J Lohse (DE): "Finding targets for heart failure therapy"14.00-15.00

Plenary session The complexity of device therapy 15.00-16.30

Frontier symposiumRevisiting the role of

Ins(1,4,5)P3 in myocardium

Frontier symposiumCarotid artery

disease: addressing therapeutic options

Frontier symposiumBasic biology of cell division and differentiation

Frontier sysmposiumRole of reactive

oxygen species (ROS)in myocardial physio-

logy and pathology

Frontier symposiumCholesterol: are statins enough?

Frontier symposiumZ-disc and M-bandproteins and theirimplications for

human heart disease

Poster mounting8 .00 -9 .00


12.30-14.00 Lunch symposium Recent developments on the role of ARBs in protecting the heart and the brain and Moderated posters with lunch




Free evening

Frontier symposiumEndothelial dysfun-

ction in hypertensionand heart failure:

from bench to bedside

Plenary session The complexity of the heart beat

Frontier symposiumThe Iƒ current:

a new therapeutictarget

9.00-10.30

Hall Santa Lucia

34

Hall Europa Saturday June 23, 2007 – 9.00-10.30 Hall Europa

Plenary Session

Organized with an unrestricted educational grant from Servier

THE COMPLEXITY OF THE HEART BEAT

ChairingK Fox (London, UK), A Maseri (Milan, IT)

09.00 Cellular control of heart rate 028 M Shattock (London, UK)

09.20 Manipulating the pacemaker current to optimize heart rate 029M Rosen (New York, USA)

09.40 Heart rate and its manipulation in the detection andprevention of sudden cardiac death 030

P J Schwartz (Pavia, IT)

10.00 Pharmacological control of heart rate 031J Borer (New York, USA)

Coffee Break

35

Saturday June 23, 2007 – 11.00-12.30

Frontier Symposia

Organized with an unrestricted educationalgrant from Servier

THE Iƒ CURRENT: A NEW THERAPEUTIC TARGET

FOR CARDIOVASCULAR DISEASES

Chairing R Ferrari (Ferrara, IT), M Rosen (New York, USA)

11.00 The “Physiological” Iƒ current 032D Di Francesco (Milan, IT)

11.20 The “Pathological” Iƒ current 033E Cerbai (Florence, IT)

11.40 Selective heart rate reduction in myocardial ischaemia 034G Heusch (Essen, DE)

12.00 Targeting the If current in the clinic 035J C Tardif (Montreal, CA)

Organized with an unrestricted educationalgrant from A. Menarini and Menarini International

ENDOTHELIAL DYSFUNCTION IN HYPERTENSION AND HEART FAILURE:FROM BENCH TO BEDSIDE

Chairing L J Ignarro (Los Angeles, USA), A Oto (Ankara, TR)

11.00 Endothelial dysfunction in hypertension: the bench side 036S Taddei (Pisa, IT)

11.20 Endothelial dysfunction in hypertension: the bedside 037 G Ambrosio (Perugia, IT)

11.40 Endothelial dysfunction in heart failure: the bench side 038U Landmesser (Hannover, DE)

12.00 Endothelial dysfunction in heart failure: the bedside 039M G Modena (Modena, IT)


36

Saturday June 23, 2007 – 11.00-12.30

Frontier Symposia

The ISHR European Section Symposium

REVISITING THE ROLE OF INS(1,4,5)P3 IN MYOCARDIUM

Chairing D Eisner (Manchester, UK), J Kentish (London, UK)

11.00 IP3 in atrial myocardium: what is it good for? 040J Kockskämper (Göttingen, DE)

11.20 Inositol 1,4,5-trisphosphate; an agonist for inotropy, arrhythmias and hypertrophy 041M D Bootman (Cambridge, UK)

11.40 IP3-R signaling in myocardium 042D Bers (Chicago, USA)

12.00 IP3 in cardiac arrhythmias and pathology 043E Woodcock (Melbourne, AUS)

The ISHR North-American Section Symposium

Z-DISC AND M-BAND PROTEINS AND THEIR IMPLICATIONS

FOR HUMAN HEART DISEASE

Chairing G Vescovo (Vicenza, IT), N J Severs (London, UK)

11.00 The sarcomeric Z-disc – an overview 044J Chen (La Jolla, USA)

11.20 Mechanically modulated signaling by titin kinase 045 M Gautel (London, UK)

11.40 MLP and telethonin in cardiomyopathies 046R Knoell (Göttingen, DE)

12.00 Do families with cardiomyopathy benefit of new knowledge on sarcomeric protein defects? 047E Arbustini (Pavia, IT)


37

Saturday June 23, 2007 – 11.00-12.30

Frontier Symposia

Organized with an unrestricted educational grant from Merck Sharp & Dohme and Schering Plough

CHOLESTEROL: ARE STATINS ENOUGH?

Chairing R Fellin (Ferrara, IT), M Hori (Osaka, JP)

11.00 Cardiovascular risk management: evolving aims 048 C Rapezzi (Bologna, IT)

11.20 The lower the better in lipid management: truth or myth 049A P Maggioni (Florence, IT)

11.40 The dual inhibition of the two sources of cholesterol. A new option to manage the risk 050G F Gensini (Florence, IT)

12.00 Evolving concepts on dyslipidemia, atherosclerosis, and cardiovascular disease 051B Masri (New York, USA)

The ISHR Australasian Section Symposium

ROLE OF REACTIVE OXYGEN SPECIES (ROS) IN MYOCARDIAL

PHYSIOLOGY AND PATHOLOGY

Chairing J Headrick (Southport, AUS), S Pepe (Melbourne, AUS)

11.00 ROS-induced ROS release in the cardiac myocyte 052 D Zorov (Moscow, RU)

11.20 ROS regulation of ion channel function 053L Hool (Crawley, AUS)

11.40 Role of ROS in diabetic myopathic damage in the heart 054R H Ritchie (Melbourne, AUS)

12.00 Myocardial purine metabolism, ROS and ischemic tolerance 055J Headrick (Southport, AUS)


38

Saturday June 23, 2007 – 11.00-12.30

Frontier Symposia

The ISHR - Bayer Japan Symposium

BASIC BIOLOGY OF CELL DIVISION AND DIFFERENTIATION

Chairing C A Beltrami (Udine, IT), C Ventura (Bologna, IT)

11.00 First cell fate decisions in the earlymouse embryo 056M Zernicka-Goetz (Cambridge, UK)

11.20 Probing heart induction with embryology and high throughput chemical biology 057M Mercola (La Jolla, USA)

11.40 Regulation of cardiac myocyte growth and death 058M Xie (Houston, USA)

12.00 A novel cardiomyocyte differentiation factor 059I Komuro (Chiba, JP)

The Fondazione Villa Maria Cecilia Symposium

CAROTID ARTERY DISEASE: ADDRESSING THERAPEUTIC OPTIONS

Chairing A Cremonesi (Ravenna, IT), G F Percoco (Ferrara, IT)

11.00 High risk carotid plaque:how to detect and treat 060A Cremonesi (Ravenna, IT)

11.20 Endovascular treatment of acute stroke 061 G Schroth (Bern, CH)

11.40 Alternative therapies for carotid artery stenosis 062C Setacci (Siena, IT)

12.00 Technical aspects of carotid artery stenting 063F Castriota (Ravenna, IT)

Hall Bianca - Holiday Inn Hotel Hall Azzurra - Holiday Inn Hotel

Organized with an unrestricted educationalgrant from Merck Sharp & Dohme and Sigma-Tau

RECENT DEVELOPMENTS ON THE ROLE OF ARBS

IN PROTECTING THE HEART AND THE BRAIN

ChairingA Branzi (Bologna, IT), D J Hearse (London, UK)

12.30 The deleterious role of Angiotensin II in the development of myocardial hypertrophy, cardiovascular fibrosis and arterial stiffness:an evolutionist perspective 064C Rapezzi (Bologna, IT)

12.50 The beneficial effects of ARBs in reducing fibrosis and improving myocardial functions 065J Diez (Pamplona, ES)

13.10 The role of non antiarrhythmic agents in the prevention of atrial fibrillation 066K Wachtell (Copenhagen, DK)

13.30 Heart and brain: from myocardial dysfunction to stroke risk 067G Iaccarino (Naples, IT)

Hall Italia Saturday June 23, 2007 – 12.30-14.00 Hall Italia

Lunchtime Symposium

39

RESEARCH ACHIEVEMENT AWARD

This Award recognizes an outstanding scientist who hasmade major and independent contributions to the advancement of cardiovascular science and who is

likely to further develop his/her research in the future

Martin J Lohse (Würzburg, DE) 068

“Finding targets for heart failure therapy”

Chair: J Downey (Mobile, USA)


ISHR Award

40

41


Plenary Session

The Universities of Ferrara and Pavia Symposium

THE COMPLEXITY OF DEVICE THERAPY

ChairingP Alboni (Cento, IT), P E Vardas (Heraklion, GR)

15.00 The “epidemiology” of therapeutic devices:application of the Guidelines in the real world 069

J C Daubert (Rennes, FR)

15.20 Mechanical vs. biological effects of CRT 070S Ghio (Pavia, IT)

15.40 New perspectives in monitoring devices 071A Auricchio (Lugano, CH)

16.00 A new look at the devices’ failures 072 L Kappenberger (Lausanne, CH)

Coffee Break

42

Saturday June 23, 2007 – 17.00-18.30

Frontier Symposia


ALDOSTERONE AND HEART FAILURE

Chairing M G Modena (Modena, IT), O Visioli (Parma, IT)

17.00 Role of aldosterone in ventricular remodeling 073M G Modena (Modena, IT)

17.20 Aldosterone as a risk factor in stable chronic heart failure 074I Anand (Minneapolis, USA)

17.40 Clinical trials with antialdosterone drugs 075 M Gheorghiade (Chicago, USA)

18.00 Focus on eplerenone:results of recent trials 076F Zannad (Nancy, FR)

The Fondazione Salvatore Maugeri Symposium

BIOMARKERS AND INFLAMMATION

Chairing M Marzilli (Siena, IT), M Simoons (Rotterdam, NL)

17.00 Biomarkers of myocardial ischemia 077F Andreotti (Rome, IT)

17.20 CRP as a marker and mediator in acute coronary syndromes 078E Yeh (Houston, USA)

17.40 CD40 ligand and cardiovascular risk 079 F Violi (Rome, IT)

18.00 Troponins in clinical practice: from molecular alterations to diagnostic applications 080D Atar (Oslo, NO)


43

Saturday June 23, 2007 – 17.00-18.30

Frontier Symposia

The Medical Trials Analysis Symposium

FROM BENCH TO BEDSIDE:THE CHALLENGE OF MANAGING ACUTE THROMBOSIS

Chairing M Hamon (Caen, FR), M Tubaro (Rome, IT)

17.00 Anti-platelet therapy: different molecular targets for different clinical effects? 081D Ardissino (Parma, IT)

17.20 Is blockade of IIb/IIIa receptors in combination with antiplatelet and antithrombotic therapy necessary? 082L Bolognese (Arezzo, IT)

17.40 Why and when GPIIb/IIIa for NSTEMI patients? 083C W Hamm (Bad Nauheim, DE)

18.00 Why and when GPIIb/IIIa for STEMI patients? 084M Valgimigli (Ferrara, IT)


SPATIAL ORGANIZATION OF SIGNALING

PATHWAYS IN CARDIAC MYOCYTES

Chairing L Neyses (Manchester, UK), P H Sugden (London, UK)

17.00 Spatial organization of NOS signaling 085B Casadei (Oxford, UK)

17.20 Spatial organization of cardiac proteasome complexes 086 P Ping (Los Angeles, USA)

17.40 Spatial organization of PKC signaling 087S F Steinberg (New York, USA)

18.00 Spatial organization of cyclic nucleotide signaling 088R Fischmeister (Paris, FR)


44

Saturday June 23, 2007 – 17.00-18.30

Frontier Symposia

The Fondazione Policlinico S. Matteo Symposium

NEW UNDERSTANDING IN ATRIAL FIBRILLATION

Chairing G Boriani (Bologna, IT), L Padeletti (Florence, IT)

17.00 Electrophysiological mechanisms of atrial fibrillation 089 S Knecht (Haut l’Evéque, FR)

17.20 The role of implantable device to reduce atrial fibrillation 090A Schuchert (Neumünster, DE)

17.40 The role of ablation in atrial fibrillation: clinical results 091C Pappone (Milan, IT)

18.00 Ablation and activation of circulating EPC 092C Pratola (Ferrara, IT)

The ISHR Australasian Section Symposium

ANGIOTENSIN – GROWTH AND FUNCTIONAL MODELING IN THE HEART

Chairing L Delbridge (Melbourne, AUS), M Vila Petroff (La Plata, RA)

17.00 Non-AT1 receptor-mediated cardiovascular effects of angiotensin peptide fragments 093 R Widdop (Clayton, AUS)

17.20 Early angiotensin II cardiac growth dysregulation predisposes for later hypertrophic response 094L M D Delbridge (Melbourne, AUS)

17.40 Angiotensin II – the link between excitation con-traction coupling and LV dysfunction in CHF 095M G Vila Petroff (La Plata, RA)

18.00 Intracellular angiotensin II signaling mediates growth and inotropism 096E A Aiello (La Plata, RA)


45

Saturday June 23, 2007 – 17.00-18.30

Frontier Symposia

The ISHR – Cannon Japan Symposium

CARDIOVASCULAR REGENERATION: EMBRYONIC

VERSUS ADULT STEM CELLS

Chairing H Drexler (Hannover, DE), W Wijns (Aalst, BE)

17.00 Cardiomyocytes from embryonic stem cells 097 L Gepstein (Haifa, IL)

17.20 Characteristics of embryonic stem cell-derived cardiomyocytes 098 A Sachinidis (Köln, DE)

17.40 Cardiomyocytes from bone marrow 099K Fukuda (Tokyo, JP)

18.00 Human multipotent cells can be generated from several adult tissues 100D Cesselli (Udine, IT)


REBUILDING THE CARDIAC VESSELS:FOCUS ON ANGIOGENESIS

Chairing B Levy (Paris, FR), O Smiseth (Oslo, NO)

17.00 If current inhibition and angiogenesis 101C Thuillez (Rouen, FR)

17.20 Bradycardia and angiogenesis in the ischemic and hypertrophic heart 102 M D Brown (Birmingham, UK)

17.40 Microvascular remodeling: from angiogenesis to arteriogenesis 103T C Skalak (Charlottesville, USA)

18.00 From cardiac hypertrophy to heart failure: role of angiogenesis 104K Walsh (Boston, USA)


46

Saturday June 23, 2007 – 20.00-21.15

HALL SANTA LUCIA

Evening Lectures Evening Lectures

20.00-20.45

20.45-21.15

LANDMARK SCIENTIFIC LECTURE

Eric Olson (Dallas, USA)“Toward a molecular blueprint of heart development and disease” 105

Chair: R Ferrari (Ferrara, IT)

CULTURAL LECTURE

Anna Ottani Cavina (Bologna, IT) “Discovering Bologna.

The secret charme of a city” 106

Chair: A Branzi (Bologna, IT)

47

ELECTROPHYSIOLOGY FROM BENCH TO BEDSIDE

Saturday June 23, 2007 – 12.30-14.00

Moderated Poster Session

Moderators: D Di Francesco (Milan, IT)M Rosen (New York, USA)

P1 SPECIES PECULIARITIES IN GENERATION OF PACEMAKER ACTION POTENTIAL IN FROG, LIZARD AND RAT SINOATRIAL VALVEV Golovko

P2 AN ANALYSIS OF THE MEMBRANE UNSTABILITY IN INHERITED ARRHYTHMIAS AND IMAGINARY TREATMENT BY COMPUTER SIMULATION.N Homma; S Amran

P3 COMPUTATIONAL INVESTIGATION OF THE ADAPTATION OF ACTION POTENTIAL DURATION BY PACING RATE IN RAT MYOCYTESF Brette; S Kharche; H Zhang; L Salle

P4 POST-NATAL DEVELOPMENTAL CHANGES IN RABBIT SINOATRIAL AND ATRIOVENTRICULAR NODESE S H Abd Allah; M Boyett; H Dobrzynski

P5 INTRACELLULAR CALCIUM CLOCK IGNITES MEMBRANE CLOCKS: A NEW THEORY OF CARDIAC PACEMAKER FUNCTION AND REGULATIONV Maltsev; E Lakatta

P6 EXCITATION SPREAD IN CARDIAC MYOCYTE CULTURES USING PAIRED MICROELECTRODE AND MICROELECTRODE ARRAY RECORDINGSP Athias; S Jacquir; C Tissier; D Vandroux; S Binczak; J Bilbault; M Rosse

P7 BETA-ADRENERGIC MODULATION OF THE RATE-DEPENDENCY OF QT INTERVAL IN HUMANSG Malfatto; M Facchini; A Zaza

P8 CONDITIONAL Fkbp12.6 OVER-EXPRESSION IN MOUSE CARDIAC MYOCYTES PROTECTS FROM TRIGGERED VENTRICULAR ARRHYTHMIAB Gellen; A Gomez; L Vinet; F Briec; J Benitah; F Jaisser; F Charpentier; J Mercadier; P Rouet; M Pezet; B Escoubet

P9 EXAMINATION OF THE ROLE OF THE Na+/Ca2+ EXCHANGER IN THE GENESIS OF THE DOFETILIDE-INDUCED TORSADES DE POINTESA Farkas; S Orosz; T Forster; M Csanády; J Papp; A Varró; A Farkas

P10 SEX DIFFERENCES IN MURINE MYOCARDIAL MEMBRANE LIPID COMPOSITION MODULATE GROWTHAND POSTISCHEMIC ARRHYTHMIAC E Huggins; P L Mc Lennan; M L Theiss;T Pedrazzini; S Pepe; L M D Delbridge

Moderators: S Knecht (Haut l’Eveque, FR) A Mugelli (Florence, IT)

P11 NOVEL BRUGADA SYNDROME MUTATION (C1850S) IN THE C-TERMINUS OF SCN5A: BIOPHYSICAL AND COMPUTATIONAL ANALYSIST Jespersen; J Kucera; E Pruvot; S Petitprez; D Keller; C Corbaz; J Schlapfer; H Abriel

P12 REMODELING OF CONNEXIN 43 (Cx43) AND VENTRICULAR FIBRILLATIONI Imanaga; K Ogawa; T Mayama

48P13 ELECTROPHYSIOLOGICAL EFFECTS

OF ESCITALOPRAM IN GUINEA-PIG AND RAT PAPILLARY MUSCLEV Kecskemeti; A Szebeni; D Kiselnik; E Viragh

P14 Nhe1 OVEREXPRESSION INCREASES REPERFUSION-INDUCED VENTRICULAR FIBRILLATION (VF) SUSCEPTIBILITY IN THE MOUSE HEARTC Stables; A Cook; M Avkiran; M J Curtis

P15 REPOLARIZATION-RELATED ECG PARAMETERS DO NOT PREDICT THE PROARRHYTHMIC ACTIVITY OF DOFETILIDE IN NA-PENTOBAR-BITAL-ANESTHETIZED RABBITSS Orosz; A Farkas; P Makra; N Csík; I Leprán; L Rudas; A Varró; A Farkas

P16 A MUTATION IN CALSEQUESTRIN CAN CAUSE POLYMORPHIC VENTRICULAR TACHYCARDIAM Periasamy; A Kalyanasundaram

P17 EXPRESSION AND MODULATION OFF-CHANNELS IN CHRONIC ATRIAL FIBRILLATION: A STUDY IN HUMAN ATRIUM.F Stillitano; G Lonardo; M Del Lungo; E Cerbai; A Mugelli

P18 CRUCIAL ROLE OF HEART CELL Ca2+

HANDLING IN INITIATION, SUSTAINING AND TERMINATION OF LETHAL ARRHYTHMIAS.

N Tribulova; S Seki; P Kaplan; E Babusikova; V Knezl; S Mochizuki; M Manoach

P19 EXAMINATION OF THE ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN THE PROARRHYTHMIC ACTIVITY OF DOFETILIDEA Farkas; A S Farkas; D Vincze; P Makra; N Csík; I Leprán; A Varró; L Rudas

P20 THE EFFECT OF ATX-II ON TORSADE DE POINTES INDUCED BYE-4031 IN VIVOG Michael; K A Kane; S J Coker

Moderators: E Cerbai (Florence, IT) M Shattock (London, UK)

P21 CARDIAC SYMPATHETIC NERVE ACTIVITY AND VENTRICULAR FIBRILLATION DURING ACUTE MYOCARDIAL INFARCTION IN AMBULENT SHEEPC J Charles; D L Jardine; A M Richards

P22 HYPERTRIGLYCEROLEMIA AFFECTS MYOCARDIAL CONNEXIN-43 REMODELLING AND INCREASED INCIDENCE OF LETHAL ARRHYTHMIASM Fialova; K Dlugosova; V Knezl; L Okruhlicova; N Tribulova

P23 RESVERATROL, A NATURAL INGREDIENT OF GRAPE SKIN: ANTIARRHYTHMIC EFFICACY AND IONIC MECHANISMSY Lu; B Yang

P24 ANTIARRHYTHMIC PROTECTION BY ISCHEMIC PRECONDITIONING DOES NOT REQUIRE ACTIVATION OF Pi3k/Akt IN THE RAT HEARTT Ravingerova; J Matejikova; J Neckar;M Ivanova; M Barancik; F Kolar

P25 BENEFICIAL EFFECTS OF ADAPTATION TO HYPOXIA IN PATIENTS WITH ISCHEMIC HEART DISEASE AND EXTRASYSTOLIC ARRHYTHMIASE B Manukhina; H F Downey; S V Lyamina; N P Lyamina

P26 PEROXYNITRITE INDUCES AN ANTIARRHYTHMIC EFFECT IN ANAESTHETISED DOGSA Kiss; L Juhász; I Huliák; P Ferdinandy;Á Végh

P27 THE EFFECT OF FLECAINIDE ON CONDUCTION IS NOT DIMINISHED IN HUMAN ATRIAL FIBRILLATIONT Christ; E Wettwer; U Ravens

P28 COMPARISON BETWEEN THE EFFECTS OF ETOMOXIR AND RANOLAZINE ON CARDIAC ARRHYTHMIAS.M Najafi; T Eteraf Oskouei

P29 RANOLAZINE NORMALIZES ACTION POTENTIAL REPOLARIZATION OF HYPERTROPHIED VENTRICULAR CARDIOMYOCYTES.S Suffredini; S Brogioni; E Cerbai; L Belardinelli; A Mugelli

49P30 ß-SUBUNITS KChIP2, KCNE2 AND

DPP6 MODULATE EFFECTS OF TEDISAMIL ON TRANSIENT OUTWARD CURRENT ITO

S Radicke; D Cotella; U Ravens; E Wettwer

P31 CARDIOPROTECTIVE ROLE OF PROSTAGLANDIN E2 IN VENTRICULARCARDIOMYOCYTES INVOLVING Stat3M A Frias; C Gerber-Wicht; U Lang

Moderators: A Auricchio (Lugano, CH)M Hiraoka (Tokyo, JP)

P32 MECHANISM OF ATRIAL REVERSE REMODELING BY COMBINATION OF MULTI-ION CHANNEL BLOCKER AND ANGIOTENSINE RECPTOR BLOCKERH Fukaya; S Niwano; H Niwano; D Sato; T Izumi

P33 ANTIFIBRILLATING EFFECT OF N-3 POLYUNSATURATED FATTY ACIDS (PUFA) IN AGED HYPERTENSIVE RAT HEARTSM Fialova; K Dlugosova; V Knezl; L Okruhlicova; J Drimal; N Tribulova

P34 CARDIOPROTECTIVE EFFECTS OF CYNODON DACTYLON AGAINST ISCHEMIA/REPERFUSION-INDUCEDARRHYTHMIASM Najafi; H Nazemiyeh; A Garjani; H Ghavimi; A Gharekhani

P35 A NOVEL ANTIARRHYTHMIC TARGET: M3R/IKM3B Yang; Y Lu; J Jiao

P36 EFFECT OF IVABRADINE ON STRUCTURAL AND ELECTROPHY-SIOLOGICAL REMODELLING IN A RAT MODEL OF HEART FAILUREC Ceconi; L Comini; S Suffredini; E Cerbai; R Ferrari; M Bouly; A Mugelli

P37 IVABRADINE IMPROVED CARDIAC FUNCTION, FIBROSIS AND HYPEREXCITABILITY IN RAT POST-MI SEVERE HEART FAILURE.P Milliez; J Samuel; C Delcayre

P38 HEART RATE REDUCTION WITH IVABRADINE PROTECTS AGAINST VENTRICULAR FIBRILLATION DURING ACUTE ISCHEMIA IN PIGSF Vaillant; A Tabib; P Chevalier; B Bui-Xan; Q Timour

P39 AUTONOMIC RATE MODULATION INSAN CELLS INVOLVES CHANGES IN DIASTOLIC DEPOLARIZATION AND THE If CURRENTM Baruscotti; A Bucchi; R B Robinson; D DiFrancesco

P40 HCN CHANNELS CONTROL RHYTHMDIFFERENTLY IN ATRIA AND VENTRICLE OF THE ANOXIC-REOXYGENATED EMBRYONIC HEARTE Raddatz; A Sarre

P41 AGE-DEPENDENT CHANGES IN HCN4 AND NAv1.5 IN THE SINOATRIAL NODEJ F Yanni Gerges; J O Tellez; H Dobrzynski; M R Boyett

P42 CARDIAC SPECIFIC OVER-EXPRESSION OF HUMAN SHORT ClC-3 ISOFORM INCREASES VOLUME-SENSITIVE OUTWARDLY RECTIFYINGCHLORIDE CURRENTS IN MOUSE ATRIAL MYOCYTESJ R Hume; D Xiong; G X Wang; P Scowen; L Miller; I A Yamboliev; W J Hatton; D J Burkin

Moderators: D J Hearse (London, UK)C Pratola (Ferrara, IT)

P43 INHIBITORY EFFECT OF 4-IODOPROPOFOL ON INA IS ASSOCIATED WITH ACCELERATED VOLTAGE-DEPENDENT INACTIVATIONE Dubuis; N Bracken; G Hart; M Leuwer; M Hussain

P44 VOLTAGE-GATED K+ (KV) CHANNELS EXPRESSED IN CANINE CORONARY ARTERYU D Dincer; G M Dick; A G Obukhov; H R Besch; M Sturek; J D Tune

P45 FREQUENCY DEPENDENT EFFECTSOF IKR BLOCKADE TYPES ON ACTION POTENTIAL DURATION: A HUMAN ATRIAL MODEL STUDYY Kurachi; S Suzuki; S Murakami; K Tsujimae

P46 IKr CHANNELS ANALYSIS (ALPHA- & BETA-SUBUNITS) IN HUMAN AND DOG HEARTS

50V Szuts; N Jost; L Virag; Z Varga-Orvos; L Puskas; G Seprenyi; J G Papp; A Varro

P47 NOVEL LARGE CONDUCTANCE CALCIUM- AND VOLTAGE-ACTIVATEDK+ CHANNEL (KCa1.1) MODULATORB H Bentzen; A Nardi; S P Olesen; M Grunnet

P48 DE-REMODELING OF Kv CHANNELSIN FAILING RAT HEART: ROLE OF OXIDOREDUCTASESG J Rozanski; X Li; S Li; Z Xu; K Tang

P49 ELECTROPHYSIOLOGICAL CHARACTERIZATION OF hERG1a AND hERG1b HOMO- AND HETEROMERIC CHANNELSA P Larsen; T Jespersen; M Grunnet; S P Olesen

P50 MITO-KATP CHANNELS ARE NOT INVOLVED IN THE ANTIARRHY-THMIC EFFECT OF PEROXYNITRITEL Juhász; A Kiss; I Huliák; P Ferdinandy; Á Végh

P51 INHIBITION OF THE CARDIAC TRANSIENT OUTWARD K+ CHANNEL,KV1.4, BY POLYUNSATURATED FATTY ACIDSN E Farag; S Y Makary; J O Tellez; T W Claydon; M R Boyett

P52 ULTRA-RAPID KINETIC INTERACTIONS OF RANOLAZINE WITH HERG K+ CURRENTS Rajamani; J C Shryock; L Belardinelli

P53 EFFECTS OF CHANGES IN UNITARY CA2+ CURRENT ON CA2+-INDUCED CA2+-RELEASE FROM THE SARCOPLASMIC RETICULUMM Elkadri; E Dubuis; G Hart; M Hussain

Moderators: A Oto (Ankara, TR) P E Vardas (Heraklion, GR)

P54 ABNORMAL RYANODINE RECEPTOR CALCIUM RELEASE INDUCES ATRIAL FIBRILLATIONX H Wehrens; S Sood; M Santonastasi; H Cheng

P55 DIFFERENTIAL EFFECTS OF SERCA2a TRANSFECTION ON VENTRICULAR ARRHYTHMIA SUSCEPTIBILITY IN THE NORMAL RAT HEARTA R Lyon; P A Poole-Wilson; N S Peters; S E Harding

P56 A SIMULATION STUDY OF VOLTAGE-DEPENDENT INACTIVATION IN THE CARDIAC L-TYPE CALCIUM CHANNELY Kurachi; S Suzuki; S Murakami; I Findlay

P57 REGULATION OF L-TYPE CA2+

CHANNELS IN LEFT ATRIA OF PATIENTS WITH CHRONIC ATRIAL FIBRILLATION.D Dobrev; T Christ; P Boknik; S Wöhrl; R F Bosch; U Ravens

P58 STORE-OPERATED Ca2+ CHANNELS INVOLVE IN PACEMAKER ACTIVITY OF MOUSE SINOATRIAL NODEY Ju; M Cannell; D Allen

P59 THE PHOSPHOLEMMAN-INDUCED MODULATION OF Na/K ATPase Na AFFINITY IS DEPENDENT ON INTRACELLULAR CALCIUML M McLatchie; R G Berry; M J Shattock

P60 3-IODOTHYRONAMINE AFFECTS CALCIUM HANDLING IN RAT VENTRICULAR CARDIOMYOCYTES.S Brogioni; G Chiellini; S Suffredini; E Cerbai; R Zucchi

P61 CONTACT AND NON-CONTACT MAPPING SYSTEMS FOR VENTRICULAR TACHYCARDIA MAPPING AND ABLATIONC Pratola; T Toselli; E Baldo; P Artale;P Notarstefano; R Ferrari

P62 RF AF ABLATION: IS THE PERSISTENCE OF ALL INTRAPROCEDURAL TARGETS NECESSARY FOR LONG TERM SINUS RHYTHM MAINTENANCE?E Baldo; C Pratola; P Notarstefano; T Toselli; P Artale; R Ferrari

P63 SEDATION WITH MIDAZOLAM FOR ELECTRICAL CARDIOVERSIONP Artale; P Notarstefano; C Pratola; T Toselli; E Baldo; R Ferrari

51

RECEPTOR BIOLOGY AND FUNCTION

Moderators: S Engelhardt (Würzburg, DE)C Steenbergen (Baltimore, USA)

P64 ALPHA1 AND BETA ADRENERGIC STIMULATION ON REGULATION OF AMP-ACTIVATED PROTEIN KINASE IN HEARTM Xu; Y Bai; Z Lu; Q Han; Y Zhang

P65 α1B-ADRENOCEPTOR ACTIVATION IMPROVES POSTISCHEMIC CONTRACTION IN CARDIOMYOCYTES:CELLULAR MECHANISMSH Gao; L Chen; H Yang

P66 DECREASE IN CATECHOLAMINE SENSITIVITY MEDIATED BY BOTH ß1- AND ß2-ADRENERGIC RECEPTORSIN AGED VENTRICULAR MYOCYTESS R Farell; S E Howlett

P67 THE EFFECTS OF B2-ADRENOCEPTORAGONISTS ON CONDUCTION VELOCITY, FIELD POTENTIALS AND AUTOMATICITY IN CARDIOMYOCYTESM A Stagg; N G Patel; U Siedlecka; G K R Soppa; J Lee; M H Yacoub; C M N Terracciano

P68 BETA3-ADRENOCEPTORS MEDIATE NEGATIVE LUSITROPISM VIA NO-cGMP-PKG PATHWAYE Filice; T Angelone; S Imbrogno; D Pellegrino; C Adamo; A Gattuso;M Cerra

P69 FOOD-RESTRICTION IN OB/OB MICE RESTORES SARCOPLASMIC RETICULUM CA2+ UPTAKE, BUT NOT IN VIVO ß -ADRENERGIC RESPONSIVENESSA Van den Bergh; A Vanderper; P Vangheluwe; F Wuytack; P Herijgers

P70 ROLE OF SEX DIFFERENCES IN B-ADRENERGIC RECEPTOR RESPONSIVENESS OF DIABETIC RAT HEARTA Bilginoglu; F Amber; M Ugur; H Gurdal; B Turan

P71 POSSIBLE PATHOGENIC ROLE of ß1-ADRENOCEPTOR AUTOANTIBODIES IN PERIPARTUM CARDIOMYOPATHYG Wallukat; A Englert; S Bartel; R Hetzer; K Sliwa

P72 BETA ADRENERGIC STIMULATION OFTHE LANGENDORFF-PERFUSED PHOSPHOLEMMAN KNOCKOUT MOUSE HEARTE J Kennington; W Fuller; M J Shattock

P73 TESTOSTERONE ENHANCES CONTRACTILE RESPONSES TO α1, ß1 and ß2-ADRENOCEPTOR STIMULATION IN THE RAT HEARTS Tsang; S S C Wong; S Wu; T M Wong

P74 DIFFERENTIAL MODULATION OF MYOCARDIAL BETA-ADRENERGIC SIGNALLING BY PLASMA MEMBRANECALCIUM PUMP ISOFORMS.T M A Mohamed; D Oceandy; N Alatawi; F Baudoin; E J Cartwright; L Neyses

P75 STATUS OF ß-ADRENOCEPTOR SIGNAL TRANSDUCTION IN HEART FAILURE DUE TO VOLUME OVERLOADIN FEMALE RATS.M R Dent; P S Tappia; N S Dhalla

P76 THE MECHANISM OF ß-STIMULATIONINCREASES Ca2+ RELEASE IN CARDIOMYOCYTESG Ji; Z Chen; M L Kotlikoff

Moderators: S Harding (London, UK)E Woodcock (Melbourne, AUS)

P77 ROSUVASTATIN REDUCES MYOCARDIAL ß-ADRENOCEPTOR-DENSITY AND -HIGH AFFINITY STATE WITHOUT FUNCTIONAL CONSEQUENCESK Leineweber; R Nawratek; A Van De Sand; G Heusch; R Schulz

P78 ESMOLOL HAS A NEGATIVE INOTROPIC ACTION INDEPENDENT OF ITS ß-BLOCKER EFFECTH B Fallouh; S C Bardswell; D J Chambers; J C Kentish

52P79 INTERACTION OF VOLATILE

ANAESTHETICS WITH ß-ADRENORE-CEPTOR STIMULATIONS IN L-TYPE CA2+ CURRENT OF RABBIT VENTRICULAR MYOCYTESL Fan; S Sonoda; M Watanabe; T Kugimiya; E Inada; T Okada

P80 RAC-ROS-NF-KB-DEPENDENT UP-REGULATION OF ANGIOTENSIN TYPE 1 RECEPTORS IN RAT CARDIACFIBROBLASTSH Kurose; R Suda; Y Sato; M Nishida

P81 STRUCTURAL AND FUNCTIONAL ANALYSIS OF OLMESARTAN AS AN INVERSE AGONIST FOR ANGIOTENSINII TYPE 1 RECEPTORY Qin; N Yasuda; H Akazawa; Z Li; I Komuro

P82 CANDESARTAN LIMITS ADVERSE COLLAGEN REMODELING AND DIASTOLIC DYSFUNCTION DURING HEALING OF CANINE REPERFUSED MIB I Jugdutt; H Idikio; R R E Uwiera

P83 THE EFFECT OF LOSARTAN ON EXPRESSION OF BETA-ADRENO-CEPTORS IN CARDIOMYOCYTES OF DIABETIC AND NORMOGLYCEMIC RATSM Nesi; R Matucci; E Cerbai; L Raimondi; A Mugelli

P84 ENDOTHELINE-1 AND ANGIOTENSIN II ARE KEY MEDIATORS OF ALDOSTERONE-INDUCED INTERLEUKIN-18

EXPRESSION IN CARDIOMYOCYTEST Doi; T Sakoda; T Naka; T Akagami; M Ohyanagi

P85 IMPORTANCE OF T-TUBULAR LOCALIZATION OF ETA RECEPTORK Y Chung; J W Walker

P86 LOCALIZATION OF ET-1 RECEPTORS IN CULTURED MYOCYTES AND NONMYOCYTES USING PATIENTS’ SERA AUTOANTIBODIESL Okruhlicova; W Schulze; S Bartel; G Wallukat

P87 ROLE OF THE V1 VASOPRESSIN RECEPTOR IN PRESSURE OVERLOAD-INDUCED CARDIAC HYPERTROPHYD L Crandall; V Kasparcova; H M Semus;G P Vlasuk; O P Bueno

P88 NEGATIVE REGULATION OF TR- ß-1 RECEPTOR BY TNF-α ADMINISTRATION IN NEONATAL CARDIAC CELLS: AN EFFECT REVERSED BY T3

C Xinaris; I Mourouzis; E Livadarou; P Perimenis; D Spanou; C Pantos; D V Cokkinos

Moderators: I Anand (Minneapolis, USA)J Kentish (London, UK)

P89 CALCIUM SIGNALING IN TRANSGENICMICE OVEREXPRESSING A HUMAN

SEROTONIN 5HT4 RECEPTORJ Neumann; S Günther; U Klöckner; U Gergs

P90 CARDIAC METABOLIC RESPONSES IN THYROID RECEPTOR DYSREGULATION DURING STRESSO M Hyyti; X Ning; M Ge; N E Buroker; M A Portman

P91 SRIF RECEPTOR SUBTYPE EXPRESSION AND INVOLVEMENT INCONTRACTILE EFFECTS OF SRIF-14IN VENTRICULAR CARDIOMYOCYTESD Bell; B McMaster; Y Y Zhao; E J Kelso; E M McHenry; B J McDermott

P92 BM-573, A THROMBOXANE RECEPTOR ANTAGONIST, REDUCES DEVELOPMENT OF ATHEROSCLEROSIS IN APO E-DEFICIENT MICEC Cherdon; S Rolin; J Hanson; P V Drion; L De Leval; J O Defraigne; J M Dogné

P93 CHRONIC CAFFEINE AND NIFEDIPINE TREATMENT ALTERS CORONARY RESPONSES TO ADENOSINE RECEPTOR ANALOGUESR B Rose'Meyer; S Wee; T L Jenner

P94 ADENOSINE DEAMINASE INHIBITIONENHANCES THE INOTROPIC ACTION OF A1 ADENOSINE RECEPTOR IN HYPERTHYROID ATRIUMR Gesztelyi; J Zsuga; A Jakab; I Lekli; B Juhasz; G Szabo; A Tosaki

53P95 CIRCULATING LEPTIN AND

OSTEOPROTEGERIN LEVELS AFFECT INSULIN RESISTANCE IN HEALTHY PREMENOPAUSAL OBESEWOMENA Altun; B Ugur-Altun

P96 UROCORTIN 1 EXHIBITS POTENT INHIBITION OF CARDIAC SYMPA-THETIC NERVE ACTIVITY IN AMBULENT SHEEP

C J Charles; D L Jardine; M T Rademaker; A M Richards

P97 cAMP-DEPENDENT INOTROPIC EFFECTS ARE DIFFERENTIALLY REGULATED BY MUSCARINIC INHIBITION IN FAILING RAT VENTRICLEK A Krobert; R I Hussain; H K Mørk; E Qvigstad; I Sjaastad; J B Osnes; T Skomedal; F O Levy

P98 CAN AUTOANTIBODIES AGAINST G-PROTEIN-COUPLED RECEPTORS MODULATE CARDIAC MAST CELLS?L Okruhlicova; R Morwinski; W Schulze; G Wallukat

Moderators: S F Steinberg (New York, USA)M G Vila Petroff (La Plata, RA)

P99 REDUCED CONTRACTILE RESPONSE TO α-ADRENERGIC STIMULATION IN ATRIA FROM MICE WITH CHRONIC CARDIAC CaMKII INHIBITIONM Grimm; J H Brown; M E Anderson; T Eschenhagen

P100CALCINEURIN Aβ NULL PARTIALLY RESCUES IMPAIRED CARDIAC FUNCTION IN TARGETED OVEREXPRESSION OF L-LVDCC α1C

I Bodi; K D'Souza; M Rubio; S Nicolaou; G Fuller; L Conforti; J Molkentin; A Schwartz

P101DUAL NEGATIVE CROSS TALK BETWEEN AngII AND ALDOSTERONEON Cav3.1 EXPRESSION

L Ferron; Y Ruchon; J F Renaud; V Capuano

P102SIGNALING MOLECULAR COMPLEX ASSOCIATED WITH L-TYPE CALCIUM CHANNEL IN ATRIA.S Adachi-Akahane; I Naguro; H Izumi-Nakaseko; H Tsuru

P103ROLE OF PI3K IN MEDIATING SHORT- AND LONG-TERM EFFECTS OF IGF-1 ON CALCIUM HANDLING IN ADULT CARDIAC MYOCYTESE A Detré; V Bito; C Huysmans; K R Sipido

P104ANALYSIS OF THE COMPLEX BETWEEN CALCIUM CHANNEL ß SUBUNIT AND AHNAKH Haase; J Alvarez; D Petzhold; S Lutter;G Vassort; I Morano

P1052-HYDROXYOLEIC ACID INCREASESCA2+-TRANSIENT AND CONTRACTILITY IN RAT VENTRICULAR MYOCYTES IN A REGION- DEPENDENT MANNERG H Borchert; M Giggey; F Kolar; T M Wong; P H Backx; P V Escriba

P106THE IMMUNOSUPPRESSANT FK506 MODULATES PHOSPHOLAMBAN PHOSPHORYLATION IN THE HEARTS Bartel; E G Krause; P Karczewski

P107SERCA2 GENE TRANSCRIPTION IS REGULATED BY MITOCHONDRIAL TRANSCRIPTION FACTORS, Tfam ANDTfb2mA Watanabe; M Arai; M Kurabayashi

P1083-IODOTHYRONAMINE MODULATESSARCOPLASMIC RETICULUM CALCIUM RELEASE

INTRACELLULAR SIGNALLING PATHWAYS

54R Zucchi; G Chiellini; S Brogioni; S Ghelardoni; S Frascarelli; S Testoni; D K Grandy; E Cerbai; T S Scanlan

Moderators: B Casadei (Oxford, UK)C Terracciano (London, UK)

P109MODULATION OF CA2+ UPTAKE RATE IN SR DOES NOT AFFECT CA2+

CONTENT AND CA2+ LEAKAGE IN SAPONIN-TREATED MOUSE MYOCARDIUMS Morimoto; M Kawai; K Komukai; K Hongo; H Sasaki; S Kurihara

P110REDUCTION IN CALCIUM REFILLING OF SARCOPLASMIC RETICULUM IMPAIRS VENTRICULAR CONTRACTIN IN SEPTIC SHOCKC H B Lau; J P Bourreau

P111REGULATION OF MYOCARDIAL RELAXATION BY NEURONAL NOS: ROLE PHOSPHOLAMBAN PHOSPHORYLATION AND PHOSPHATASE ACTIVITYY H Zhang; M Zhang; C E Sears; K Emanuel; B Casadei

P112 INTERPLAY OF PHOSPHOLAMBAN INCALMODULIN CONTROL OF SARCOPLASMIC RETICULUM(SR) CALCIUM PUMP FUNCTIONN Narayanan; A Xu; I Virdee

P113Gα13-TRPC6-NFAT SIGNALING PATHWAY NEGATIVELY REGULATES

CARDIAC MYOFIBROBLAST FORMATIONM Nishida; N Onohara; H Kurose

P114 INTERPROTEIN DISULFIDE BOND FORMATION ACTIVATES PKG1µ; INDEPENDENTLY OF cGMPJ Burgoyne; M Madhani; J P Brennan; F Cuello; P Eaton

P115PROTEIN KINASE B: A NOVEL KINASETARGETING THE NA+/H+ EXCHANGER ISOFORM 1A K Snabaitis; F Cuello; M Avkiran

P116REGULATION OF CARDIAC TROPONINI PHOSPHORYLATION AND MYOFILAMENT Ca2+ SENSITIVITY BY PKD IN INTACT MYOCYTESF Cuello; S C Bardswell; R S Haworth; X Yin; M Mayr; J C Kentish; M Avkiran

P117PROTEIN KINASE D EXPRESSION AND ACTIVITY ARE UNALTERED DURING MYOFIBRILLOGENESIS IN C2C12 CELLSR S Haworth; M Avkiran

P118CLC-2 CL CHANNELS ASSOCIATES WITH A CELL MEMBRANE PKCε/Src KINASE SIGNALLNG MODULE IN CARDIOMYOCYTESR Diaz; D Wong; E Kuzmin; A Hinek; T Hossain; G Wilson

P119CONTROL OF MYOCARDIAL PKC: A NOVEL PARADIGM AND THE ROLE OF CapZQ Zhong; J Usprech; W G Pyle

Moderators: R Fischmeister (Paris, FR)P H Sugden (London, UK)

P120 THE PREGNANCY HORMONE RELAXIN INCREASES MYOFILAMENT FORCE THROUGH A PKC-DEPENDENT PATHWAYP Wood; W G Pyle

P121HYPERGLYCEMIA INDUCED CELL GROWTH AND GENE EXPRESSION VIA THE SERUM RESPONSE ELEMENT THROUGH PKCβ, RhoA AND Rho-KINASEK Ishiko; T Sakoda; T Akagami; M Ohyanagi

P122MitoKATP, H2O2, AND PKCε- COMPLETING THE CYCLEA D Costa; K D Garlid

P123PKCzeta- MEDIATED GalphaQ STIMULATION OF THE ERK5 PATHWAY PLAYS A KEY ROLE IN CARDIAC HYPERTROPHYF Mayor; C Garcia-Hoz; M Herranz; M T Diaz-Meco; J Moscat; C Ribas

P124PKC DEPRESSES CARDIAC MYOCYTEPOWER OUTPUT AND LIMITS THE PHOSPHORYLATION AND MECHANICAL EFFECTS BY PKAL M Hanft; F S Korte; K S McDonald

P125PKC CATALYTIC SUBUNIT AND PHENYLEPHRINE INDUCE A

55COMPARABLE DECREASE IN MYOFILAMENT CALCIUM SENSITIVITYJ Barta; J Van Der Velden; N M Boontje; R Zaremba; G J M Stienen

P126EXPRESSION OF DEPHOSPHORYLA-TED CX43 IN TRANSGENIC MICE HEARTS FOLLOWING ACUTE ACTIVATION OF C-JUN N-TERMINALKINASEN Chandler; S Inada; T Rogers; Y Wang; W Lederer; H Hartmann; M Boyett; H Dobrzynski

P127EFFECTS OF A NOVEL RSK INHIBITOR ON α1-ADRENERGIC REGULATION OF MYOCARDIAL NHE1F Cuello; A K Snabaitis; M S Cohen; J Taunton; M Avkiran

P128THE CARDIOPROTECTIVE SIGNALOSOMEC L Quinlan; A D T Costa; K D Garlid

P129ENHANCED ACE2 REVERSES ANGIOTENSIN II- AND IV-INDUCED PROINFLAMMATORY CYTOKINE IN HUMAN ENDOTHELIAL CELLSX Yu; J Zhong; Q Lin; Z Shan; X Li; X Huang; S Lin

Moderators: P Eaton (London, UK)J Headrick (South Port, AUS)

P130THE MYOCARDIAL RESPONSE TO ADRENOMEDULLIN INVOLVED

INCREASED CAMP GENERATION AS WELL AS AUGMENTED AKT PHOSPHORYLATIONY Qi; C Pan; J Zhao; X Wang; C Tang

P131CARBACYCLIN INDUCES CPT-1 IN CARDIAC MYOCYTES VIA PPAR δ, INDEPENDENT OF THE IP RECEPTORSIGNALING PATHWAYT Kuroda; K Yamauchi-Takihara; Y Fujio; M Hori

P132 INHIBITORY MECHANISMS OF PPARγ AGONIST, PIOGLITAZONE ON INTERLEUKIN 18-INDUCED GENE EXPRESSION IN CARDIOMYOCYTES T Sakoda; T Doi; T Naka; T Akagami; M Ohyanagi

P133NO-cGMP-PKG SIGNALLING PATHWAY INVOLVED IN THE PROTECTION OF CARDIAC MYOCYTES DURING HYPOXIA/REOXYGENATIONA Gorbe; Z Giricz; I Huliak; G F Baxter; P Ferdinandy

P134CLENBUTEROL AFFECTS RAT VENTRICULAR MYOCYTE CONTRACTILITY VIA AN INHIBITORYG PROTEIN-MEDIATED PATHWAY.U Siedlecka; M Arora; G K R Soppa; J Lee; M A Stagg; S E Harding; M H Yacoub; C M N Terracciano

P135ROLE OF PDE3 AND PDE4 FOR β-ADRENERGIC CONTROL OF cAMP AND ICa,L IN ADULT RAT VENTRICULAR MYOCYTESG Vandecasteele; J Leroy; A Abi-Gerges; W Richter; V O Nikolaev; M J Lohse; M Conti; R Fischmeister; S Engelhardt

P136 IDENTIFICATION OF PDE1 AND PDE5 IN ADULT RAT LEFT VENTRICULAR CARDIOMYOCYTES.C Lugnier; G Vandecasteele; W Mokn; R Fischmeister; T Keravis

P137ANGIOTENSIN II TYPE2 RECEPTOR - PLZF SIGNALING REQUIRES TYROSINE PHOSPHORYLATION OF PLZF BY JAK2.T Senbonmatsu; A Yoshikawa; Y Aizaki;K Maruyama; T Inagami

P138OXIDATIVE STRESS BLOCKS ACTIVATION OF JAK-STAT SIGNALING IN CARDIAC MYOCYTESG W Booz; M Kurdi

P139JAK/STAT3 SIGNALING PATHWAY IS INVOLVED IN α1-AR-MEDIATED CARDIAC HYPERTROPHYY Zhang; H Zhang; Q Han

P140p42/p44 ERK MODULATES TGF-β1-

MEDIATED PHOSPHORYLATION AND TRANSLOCATION IN CARDIAC MYOFIBROBLASTSS G Rattan; T Angelovska; B Wang; D H Freed; V Drobic; I M C Dixon

56

Moderators: L Hool (Crawley, AUS)L Neyses (Manchester, UK)

P141 PHOSPHORYLATION OF p38 BY GRK2 AT THE ENTRANCE OF ITS DOCKING DOMAIN REVEALS A NOVEL TYPE OF P38 INHIBITION.C Murga; M Jurado-Pueyo; P M Campos; S Peregrin; V Sanz-Moreno; P Crespo; F Mayor

P142P38 MAP KINASE DECREASES STRETCH-INDUCED FORCE DEVELOPMENT IN NORMAL AND FAILING MYOCARDIUM.H Post; A Kockskämper; H Kögler; D von Lewinski; B Pieske

P143CARDIOPROTECTION BY CARBON MONOXIDE (CO) IN THE ISOLATED MOUSE HEART IS DEPENDANT UPON P38-MAPK ACTIVITYJ E Clark; M S Marber

P144THE RELATIONSHIP BETWEEN P38-MAPK AND AMPK DURING MYOCARDIAL ISCHAEMIAS Jacquet; E Zarrinpashneh; A Chavey; I Leclerc; G A Rutter; L Bertrand; M S Marber

P145POST-INFARCTION REMODELING IS INDEPENDENT OF MITOGEN ACTIVATED PROTEIN KINASE KINASE 3 (MKK3)J E Clark; R A Flavell; M E Faircloth; R J Davies; M S Marber

P146PROSTANOID F RECEPTOR (FPR) INOTROPIC EFFECT IN RAT VENTRICLE IS MEDIATED BY MYOSIN LIGHT CHAIN PHOSPHORYLATIONJ Riise; C Nguyen; E Qvigstad; D Sandnes; J B Osnes; T Skomedal; F Levy; K A Krobert; H Eikemo

P147CARDIOPROTECTION FROM GSK-3βINHIBITION REQUIRES ACTIVATION OF PI-3 KINASE AND Src BUT NOT Akt, PKC, OR ERKT Krieg; H Richter; A Kuno; K Förster; S Felix

P148OPENING OF THE MITOCHONDRIALKATP CHANNEL DECRASES JNK ACTIVITY IN THE ANOXIC-REOXYGENATED EMBRYONIC HEART.A Sarre; S Gardier; F Maurer; C Bonny; E Raddatz

P149PHOSPHORYLATION OF MYOSIN BINDING PROTEIN C AFFECTS SKINNED MYOCYTE FIBER MECHANICSC W Tong; J E Stelzer; M L Greaser; P A Powers; R L Moss

P150NITRIC OXIDE-INDUCED STIMULATION OF THE CARDIAC Na/K ATPase REQUIRES PHOSPHOLEMMANA R Hall; L M McLatchie; W Fuller; M J Shattock

57

INTERMEDIATE AND ENERGETIC METABOLISM

Moderators: L Opie (Cape Town, ZA)A M L Seymour (Hull, UK)

P151 MYOCARDIAL GLUT 4 EXPRESSION IN EXPERIMENTAL URAEMIAD Aksentijevic; S Bhandari; A M L Seymour

P152HYPERINSULINEMIC NORMOGLYCEMIC CLAMP RESULTSIN HYPOLIPIDEMIA DURING CORONARY ARTERY SURGERYC J Zuurbier; F Hoek; J van Dijk; H van Wezel

P153REGULATION OF GLUCOSE UPTAKEIN CARDIOMYOCYTES BY AMP-ACTIVATED PROTEIN KINASEJ E R Ussher; C T Lee; G Lopaschuk

P154HYPERINSULINAEMIA PER SE ENHANCES MYOCARDIAL SUSCEPTIBILITY AGAINST VENTRICULAR ARRHYTHMIASB Peitl; R Döbrönte; Z Szilvássy

P155 INSULIN ATTENUATES CARDIAC DYSFUNCTION IN A RODENT MODEL OF DIET INDUCED OBESITYAND INSULIN RESISTANCEE F Du Toit; W Smith; G Norton; A Woodiwiss; A Lochner

P156MYOCARDIAL INSULIN RESISTANCEIN AGING RATS AND ITS REVERSAL BY EXERCISEF Gao; Q Li; Q J Zhang; H Zhang; K Zhang

P157THE STAGE AND TREATMENT EFFECTIVENESS OF OBESITYM Postula; A Niebisz; M Jasik; B Tarchalska; W Karnafel

P158THE OBESITY STAGES AND ELEMENTS OF METABOLIC SYNDROME.M Postula; A Niebisz; M Jasik; B Tarchalska; W Karnafel

P159EXPRESSION AND ACTIVATION OF MYOCARDIAL AMPKα ARE ALTERED IN SUCROSE-FED RATS WITH METABOLIC SYNDROMEK Carvajal; L Hernandez; D Cruz-Robles

P160ALTERATIONS IN LEVELS OF O-LINKED N-ACETYLGLUCOSAMINEMODIFIED PROTEINS IN THE URAEMIC HEARTD A Ashford; S Bhandari; K Bulmer; A M L Seymour

P161DECREASES IN SERUM THIOREDOXINAND HYPERGLYCEMIA BY ACIDITY WATER FOOTBATH AFTER LUNCH IN TYPE II DIABETICSM Higuchi; K Maetaka; Y Mizuno

P162THE ROLE OF OXIDATIVE STRESS IN THE DEVELOPMENT OF MYOCARDIAL DIASTOLIC DYSFUNCTION WITH DIABETES MELLITUSO D Prysyazhna; V Sagach

Moderators: M D Bootman (Cambridge, UK)G D Lopaschuk (Edmonton, CA)

P163PREVENTION OF CARDIOVASCULAR COMPLICATIONS IN AGED DIABETIC RATS BY RESVERATROLA Fenning; H El Phyu

P164THE EFFICACY OF A HOME-BASED RESISTANCE EXERCISE TRAINING PROGRAM FOR THE TREATMENT OF TYPE II DIABETESA Fenning; K Perkins; L Davies; L Knott; P Reaburn

P165EFFECT OF ATORVASTATIN THERAPYIN THE ADIPONECTIN LEVELS IN ANANIMAL MODEL OF DIABETES AND HYPERCALORIC DIETP Monteiro; P Matafome; M Paiva; R Carreira; R Seica; L Goncalves; L A Providencia

P166EFFECT OF CHRONIC METFORMIN THERAPY IN THE MITOCHONDRIAL FUNCTION IN AN EX-VIVO ANIMAL

58MODEL OF DIABETES AND HYPER-CALORIC DIET SUBMITTED TO GLOBAL MYOCARDIAL ISCHEMIA-REPERFUSIONP Monteiro; P Matafome; M Paiva; R Carreira; R Seica; L Goncalves; L A Providencia

P167 IMPACT OF THE CHRONIC THERAPYWITH LIPID LOWERING AND ANTIDIABETIC DRUGS IN THE PROTEIN OXIDATIVE STRESS LEVELS IN AN ANIMAL MODEL OF DIABETES TREATED WITH AN HYPERCALORIC DIETP Monteiro; P Matafome; M Paiva; R Carreira; R Seica; L Goncalves; L A Providencia

P168MITOCHONRIAL SIGNALING IN DIABETIC RAT HEART: ACUTE PHASE OF THE DISEASEA Ziegelhoeffer; O Pechanova; M Ferko; T Holotnakova; J Mujkosova; I Waczulikova; S Pastorekova

P169POTASSIUM FLUXES AND ENERGY METABOLISM IN BEATING DIABETIC RAT HEARTSO Jilkina; B Kuzio; V V Kupriyanov

P170DE NOVO EXPERIMENTAL ANIMAL MODEL OF METABOLIC SYNDROMES Lin; X Huang; X Yu; H Fei; Y Fu; X Liu; W Wu

P171CHANGES IN BIOPHYSICAL PROPERTIES OF MYOCYTES AND

SUBCELLULAR MEMBRANES IN EARLY STREPTOZOTOCIN-DIABETICHEARTI Waczulikova; M Cagalinec; D Habodaszova; M Brezani; D J Chorvat; L Sikurova; A Ziegelhoeffer

P172METABOLIC ALTERATIONS BEYONDFATTY ACID OXIDATION IN PPAR ALPHA NULL MICE HEARTS: EFFECT OF WORKLOAD AND FASTINGR Gélinas; B Bouchard; J McDuff; G Charron; C Des Rosiers

P173 IN VIVO ADMINISTRATION OF TETRADECYLTHIOACETIC ACID (TTA ) IN MICE CAUSES CARDIAC INEFFICIENCY AND REDUCED POST-ISCHEMIC VENTRICULAR FUNCTIONA D Hafstad; A M Khalid; O J How; R Berge; T S Larsen; E Aasum

Moderators: K Clarke (Oxford, UK)H Taegtmeyer (Houston, USA)

P174DECREASED TRIGLYCERIDE TURNOVER IN PGC1αKO MICE DURING ADRENERGIC STRESSN Banke; T C Leone; J Lehman; D P Kelly; E D Lewandowski

P175FENOFIBRATE EXACERBATES ABERRANT CARDIOLIPIN PROFILE AND MITOCHONDRIAL DYSFUNCTION IN THE FAILING SHHF RAT HEARTA J Chicco; S A McCune; M L Rees; R T Gardner; R L Moore; G C Sparagna

P176A HIGH FAT DIET DECREASES PLASMA INSULIN AND PREVENTS PRESSURE OVERLOAD INDUCED CARDIAC DYSFUNCTION AND HYPERTROPHY K M O'Shea; M K Duda; T A McElfresh;B D Hoit; W C Stanley

P177REGULATION OF CARDIAC SUBSTRATEUTILIZATION BY PROTEIN O-GLYCOSYLATIONN Fulop; A Onay-Besikci; R B Marchase; J C Chatham

P178STIMULATION OF CARDIAC GLYCOLYSIS BY GLUCAGON: INVOLVEMENT OF PI3-KINASE BY NOT CYCLIC AMPJ Harney; R L Rodgers

P179LOCALIZATION OF MALATE-ASPARTATE SHUTTLE AND METABOLIC COMMUNICATION DURING MYOCARDIAL ISCHEMIAM Lu; W Stanley; M Cabrera; G Saidel; X Yu

P180CHRONIC ACTIVATION OF CARDIOPROTECTIVE cGMP SIGNALING INVOLVES CHANGES IN ENERGY SUBSTRATE SELECTION.R Khairallah; M E Young; B Allen; G Lopaschuk; C Deschepper; C Des Rosiers

P181ALA-DIET PREVENTS MYOCARDIAL DAMAGE IN HEREDITARY CARDIOMYOPATHY

59R Fiaccavento; F Carotenuto; M Minieri; G Forte; P Cossa; P Di Nardo

P182EXERCISE PRIOR TO MYOCARDIAL INFARCTION IMPROVES CARDIAC HEALING THROUGH ALTERATIONS IN HEART ENERGY METABOLISMA Dayan; A Katz; M Scheinowitz

P183EFFICACY OF METABOLIC INTERVENTIONS AFTER CORONARYOCCLUSION IN RATSO Pisarenko; I Studneva; L Serebryakova; O Tskitishvili

P184BIOTINYL DIMEDONE (BD) - A NOVEL REAGENT FOR STUDYING PROTEIN SULFENIC ACIDSR Charles; G L May; P Free; P R J Gaffney; P Eaton

Moderators: B McDermott (Belfast, UK)B Turan (Ankara, TR)

P185 THE EFFECT OF INCREASED [CA2+] ON MYOCARDIAL FUNCTION AND ENERGY PROVISION IN EXPERIMENTAL URAEMIAD Aksentijevic; S Bhandari; A M L Seymour

P186REGULATION OF MYOCARDIAL CREATINE UPTAKE CAPACITY IN GENETICALLY ALTERED MOUSE MODELS

M ten Hove; A Fisher; L Sebag-Montefiore;D Medway; J Wallis; D Isbrandt; S Neubauer

P187ROLE OF INTRAMOLECULAR COLLABORATION FOR PROTEIN STABILITY, SUBNUCLEAR COMPARTMENTALIZATION, AND COACTIVATOR FUNCTION OF PGC-1M Sano; S Tokudome; C Ogawa; N Shimizu; N Yoshikawa; H Tanaka; K Fukuda

P188OPTICAL IMAGING OF OXYGEN SATURATION IN BEATING KATP-DEFICIENT MOUSE HEARTSO Jilkina; M Glogowski; B Kuzio; P A Zhilkin; V V Kupriyanov

P189EFFECTS OF HYPOTHYROID STATE ON CARDIAC ENERGY METABOLISMR Ventura-Clapier; Y Athéa; D Fortin; L Bahi; A Garnier; V Veksler

P190ACTIVATED PKCε OVEREXPRESSIONPROTECTS THE HEART BY GSK3β-MEDIATED MODULATION OF CARDIACGLYCOGEN CONTENTJ McCarthy; L H Opie; M N Sack; M F Essop

P191ENERGY TRANSFER IN CARDIAC CELLS: STRUCTURE-FUNCTION RELATIONSHIPSE Seppet; M Eimre; K Paju; L Kadaja; E Orlova

P192COMPLETE ABSENCE OF CREATINE

BUT UNALTERED ATP LEVELS IN HEARTS FROM AGAT KNOCKOUT MICEM ten Hove; R Peco Navio; L Sebag-Montefiore; I Hunyor; K Clarke; D Isbrandt; S Neubauer

P193AGING-INDUCED ALTERATIONS IN GENE TRANSCRIPTS OF MITOCHONDRIAL ENERGETIC PATHWAYS IN THE HEARTC C Cabrera Aguilera; A S Oberlin; S Sagar; R H Khazi Syed; A Jahangir

P194SYNERGISTIC GENERATION OF H2O2 BY NADPH OXIDASE AND COMPLEX I OF MITOCHONDRIA IN RAT HEART HOMOGENATESR A Haworth; K T Potter

P195MONOAMINE OXIDASE A INHIBITION PREVENTS OXIDATIVE STRESS IN ISOLATED MITOCHONDRIA AND HL-1 CARDIOMYOCYTESN Kaludercic; A Carpi; N Paolocci; F Di Lisa

60

GENETICS, GENE BIOLOGY AND MOLECULAR BIOLOGY

Moderators: E Arbustini (Pavia, IT) J Chen (La Jolla, USA)

P196GENOTYPE:PHENOTYPE CORRELATIONS IN HYPERTROPHIC CARDIOMYOPATHY (HCM) REVISITED: THE EFFECTS OF HCM FOUNDER MUTATIONS IN SOUTH AFRICAN FAMILIESJ C Moolman-Smook; M Revera; M Heradien; A Goosen; P Brink

P197PROINFLAMMATORY MULTI GENE RISK PROFILE ASSOCIATED WITH ACUTE MYOCARDIAL INFARCTIONF Licastro; M Chiappelli; E Porcellini; C M Caldarera; C Caruso; D Lio; E Corder

P198FATAL HYPERTROPHIC CARDIOMYOPATHY AND NEMALINE MYOPATHY ASSOCIATED WITH ACTA1 K336E MUTATIONS Marston; E Bertini; C Graziano; S Petrini; A D'Amico; F Santorelli; G Pacileo; C Sewry; A Porfirio

P199MYBP-C MUTATION, EXPRESSION AND PHOSPHORYLATION IN NON-FAILING, FAILING AND HOCM HUMAN HEART MUSCLES Marston; O Copeland; A Jacques

P200 IMPACT OF ENDOTHELIN-A-RECEPTOR BLOCKADE ON GENE EXPRESSION POST MIW Dietl; G Mitterer; M Bauer; K Trescher; W Schmidt; B K Podesser

P201MODULATION OF CARDIAC GENE EXPRESSION PROFILE BY N-3 PUFAs AND ITS IMPLICATION IN HYPERTROPHY AND HEART FAILUREA Bordoni; A Astolfi; L Morandi; A Pession; F Danesi; M Di Nunzio; M Franzoni; A Pession

P202GENE EXPRESSION CHANGE IN DIABETIC AND NON DIABETIC RAT HEARTS PERFUSED WITH HIGH LEVELS OF GLUCOSEG Rodolico; E Piegari; M R Vitelli; E Damiano; F Rossi; L Berrino

P203 INHIBITION OF PGC-1B EXPRESSION BY THE CLASS II HISTONE DEACETYLASE HDAC5M P Czubryt; B Abrenica; L Lamoureux

P204RETROVIRAL c-Ski OVEREXPRESSIONATTENUATES PROCOLLAGEN TYPE I SYNTHESIS IN PRIMARY CARDIAC MYOFIBROBLASTSR H Cunnington; S Rattan; K M Bedosky; M A Prociuk; I M C Dixon

P205CARDIAC SODIUM-CALCIUM EXCHANGER REGULATION BY NKX2-5 AND THREE HUMAN NKX2-5MUTATIONST X O'Brien; M Rackley; D Menick; B S Harris

Moderators: G Vescovo (Vicenza, IT) S Pepe (Melbourne, AUS)

P206REGULATION OF HYPOXIA-INDUCIBLE-FACTORS IN HUMAN MACROPHAGES – INVOLVEMENT OF THE NATURAL ANTISENSE OF HIF-1α(AHIF)D M Poitz; A Augstein; R C Braun-Dullaeus; R H Strasser; A Schmeisser

P207MUTATION OF SER766/770/771 INHIBITS ACIDOSIS-ERK-DEPENDENTACTIVATION OF THE Na+/H+

EXCHANGER IN THE MYOCARDIUME Coccaro; L Fliegel

P208EXPRESSION OF N-METHYL-D-ASPARTATE RECEPTORS DURING HEART DEVELOPMENTG Moreno-Gonzales; J Guzmán-Bárcenas;G Rodriguez; A Zarain-Herzberg

P209THE PROXIMAL PROMOTER OF THE CARDIAC CALSEQUESTRIN GENE

61PROVIDES TISSUE SPECIFIC EXPRESSIONJ L Reyes-Juarez; G Rodríguez; A Zarain-Herzberg

P210TRANSCRIPTIONAL ACTIVATION OF THE SERCA2 GENE BY CALCIUM IN CARDIAC MYOCYTESA Zarain-Herzberg; G Rodriguez

P211GROWTH FACTOR REGULATION OF THE S100A6 PROMOTER IN CARDIAC MYOCYTESJ N Tsoporis; W Lesniak; T G Parker

P212CARDIAC-SPECIFIC EXPRESSION AND REGULATION OF FGF-16A G Sofronescu; Y Jin; P A Cattini

P213EXPRESSION CHANGES OF GROWTH FACTOR RECEPTOR AND MICRORNAS IN MYOCARDIUM MVECS AND RELATION WITH ANGIOGENESISH Jin; X Wang; G Zhang; R Hu

P214LENTIVIRUS VECTOR-MEDIATED SERCA2 GENE TRANSFER AMELIORATES HEART FAILURE INDUCED BY MYOCARDIAL INFARCTION IN RATM Arai; K Niwano; A Watanabe; M Kurabayashi

P215CA2M IS A NOVEL VEHICLE FOR TARGETED GENE DELIVERY INTO

MYOCARDIUMS N Ramasamy; A Rathinavel; G S Selvam

P216CARDIAC DELIVERY OF eGFP TRANSFECTED OVINE FIBROBLASTSUSING PERCUTANEOUS RECIRCULATION IN A LARGE ANIMAL MODELM Byrne; A Smolic; A Preveolos; C Galli; G Lazzari; D Brunetti; G Condorelli; D Kaye

Poster mounting

Sunday June 24, 2007


12.30-14.00

8.00-9.00

11.00-12.30

Frontier symposiumA road map for cardiogenesis

Richard J.BingAward for Young

Investigators

Frontier symposiumHeart rhythm and

arrhythmias

Frontier symposiumHeart failure: what

have we understood so far?

Frontier symposiumRole of reactive

oxygen species inthe control of coro-

nary blood flow

17.00-18.30Frontier symposiumRole of the angioten-sin II AT2 receptors

in cardiovascular disease

Frontier symposiumHow best to controlCV risk in diabetes

patients



Frontier symposiumUpdate on SCD

prevention in dilated

cardiomyopathy

Frontier symposiumPotential gene

therapy targets in cardiovascular disease


Keith Reimer Distinguished Lecture: Eduardo Marbàn (USA): "Stem cells for cardiac regeneration"14.00-15.00

Plenary session The complexity of diabetes15.00-16.30

Frontier symposiumSignaling

mechanisms regulating apoptosis

Landmark Scientific Lecture: Salim Yusuf (CA): "Cardiovascular diseases: a maladaptation to societal progress?" 20.00-20.45

Frontier symposiumPKD signaling:

alphabetical progres-sion or fundamental

progress?

Frontier symposiumTranslating the rege-nerative potential:focus on ischemiaand angiogenesis

Frontier symposiumNutritional strategiesto prevent cardiova-

scular disease: a current review


Lunch symposium The heart of the matter: a career in cardiovascular research and Moderated posters with lunch

Frontier symposiumACE inhibition: stilla long way to go fora full understanding

Frontier symposiumTrials and

tribulations of p38-MAPK

Lunch Lecture JIKEI HEART STUDY - Results and relevance in context of existing morbi-mortality data and Moderated posters with lunch

Plenary session The complexity of the metabolic syndrome

Frontier symposiumManaging the

metabolic syndrome:a multifactorial

approach

ISHR fellows dinner

Hall Santa Lucia

9.00-10.30

63

Hall Europa Sunday, June 24, 2007 – 09.00-10.30 Hall Europa

Plenary Session

Organized with an unrestricted educational grant from Pfizer

THE COMPLEXITY OF THE METABOLIC SYNDROME

ChairingR Paoletti (Milan, IT), H Taegtmeyer (Houston, USA)

09.00 How to define it? 107 C Borghi (Bologna, IT)

09.20 How does the syndrome develop? The Neel hypothesis revisited 108

P J Grant (Leeds, UK)

09.40 How important worldwide? 109S Yusuf (Hamilton, CA)

10.00 How and what to treat? 110M Volpe (Rome, IT)

Coffee Break

64

Sunday June 24, 2007 – 11.00-12.30

Frontier Symposia


MANAGING THE METABOLIC SYNDROME: A MULTIFACTORIAL APPROACH

Chairing G Rosano (Rome, IT), A Salvetti (Pisa, IT)

11.00 By controlling metabolism 111L Opie (Cape Town, ZA)

11.20 By reducing blood pressure 112A Zanchetti (Milan, IT)

11.40 By controlling dyslipidemia 113M Arca (Rome, IT)

12.00 By employing new drugs 114C Borghi (Bologna, IT)


ACE INHIBITION: STILL A LONG WAY TO GO FOR A FULL UNDERSTANDING

Chairing C Pepine (Gainesville, USA), W Remme (Rhoon, NL)

11.00 ACE inhibition and endothelial cell 115C Ceconi (Ferrara, IT)

11.20 ACE inhibition and prevention of diabetes and atrial fibrillation 116J C Tardif (Montreal, CA)

11.40 Consistent beneficial effects of ACE inhibitors in stable coronary artery disease 117M Simoons (Rotterdam, NL)

12.00 ACE inhibitors – Effects beyond blood pressure lowering 118A Hall (Leeds, UK)


65

Sunday June 24, 2007 – 11.00-12.30

Frontier Symposia


TRIALS AND TRIBULATIONS OF P38-MAPK

Chairing M Marber (London, UK), Y Wang (Los Angeles, USA)

11.00 Mechanisms at the basisof p38-MAPK activation 119M Marber (London, UK)

11.20 Consequences related top38-MAPK activation 120R Schulz (Essen, DE)

11.40 Effects of p38-MAPK inhibition in preclinical models 121R Willette (King of Prussia, USA)

12.00 Early clinical experience of p38-MAPK inhibition 122 R Mohanlal (Boston, USA)

The ISHR - Kaito Japan Symposium

POTENTIAL GENE THERAPY TARGETS IN CARDIOVASCULAR DISEASE

Chairing E Arbustini (Pavia, IT), M Komajda (Paris, FR)

11.00 LOX-I as a potential therapeutic target for cardiovascular disease 123T Sawamura (Osaka, JP)

11.20 Engineered stem cells as agents for therapeutic angiogenesis 124 K Webster (Miami, USA)

11.40 Gene therapy to enhance myocardial contraction 125S Harding (London, UK)

12.00 Gene therapy to mend the cardiac pacemaker 126M Rosen (New York, USA)


66

Sunday June 24, 2007 – 11.00-12.30

Frontier Symposia

The Fondazione Cassa di Risparmio di Cento Symposium

SUDDEN CARDIAC DEATH PREVENTION IN DILATED

CARDIOMYOPATHY

Chairing S Favale (Bari, IT), T Toselli (Ferrara, IT)

11.00 Pharmacological strategy to prevent SCD in dilated cardiomyopathy 127 A Gavazzi (Bergamo, IT)

11.20 What device therapy adds to pharmacological treatment 128J G F Cleland (Hull, UK)

11.40 Cost/benefit considerations 129 M Landolina (Pavia, IT)

12.00 From treatment to management:future role for devices 130F Braunschweig (Stockholm, SE)


PKD SIGNALING: ALPHABETICAL PROGRESSION OR FUNDAMENTAL PROGRESS?

Chairing M Avkiran (London, UK), S F Steinberg (New York, USA)

11.00 Protein kinase D: an enzyme at the heart of the matter 131 J van Lint (Leuven, BE)

11.20 Signaling mechanisms through PKD and substrate phosphorylation 132A Toker (Boston, USA)

11.40 PKD signaling in myocardium 133 M Avkiran (London, UK)

12.00 PKD as a regulator of cardiac gene expression 134T A McKinsey (Westminster, USA)


67

Sunday June 24, 2007 – 11.00-12.30

Frontier Symposia


TRANSLATING THE REGENERATIVE POTENTIAL: FOCUS ON ISCHEMIA AND ANGIOGENESIS

Chairing M Tendera (Katowice, PL), J T Willerson (Houston, USA)

11.00 New molecules for cardiovascular repair with human mesenchymal stem cells 135 C Ventura (Bologna, IT)

11.20 Cytokines and cardiovascular regeneration 136 M C Capogrossi (Rome, IT)

11.40 Myocardial repair by cardiac stem cells 137R Bolli (Louisville, USA)

12.00 Peripheral mobilization of bone marrow stem cell during myocardial infarction: facts or fiction? 138M Valgimigli (Ferrara, IT)


NUTRITIONAL STRATEGIES TO PREVENT CARDIOVASCULAR DISEASE:A CURRENT REVIEW

Chairing G Béréziat (Paris, FR), C Sirtori (Milan, IT)

11.00 Endothelial dysfunction in the elderly: mechanisms and nutritional therapy 139F Visioli (Paris, FR)

11.20 B-vitamins and cardiovascular risk 140 M Olthof (Amsterdam, NL)

11.40 Omega 3 fatty acids in cardiovascular protection: molecular mechanisms 141G Béréziat (Paris, FR)

12.00 The use of omega 3 fatty acids in clinical practice 142A P Maggioni (Florence, IT)


68

Sunday June 24, 2007 – 12.30-14.00

Lunchtime activities

The Novartis Lecture

RESULTS AND RELEVANCE IN CONTEXT OF EXISTING

MORBI-MORTALITY DATA

Chairing M Hiraoka (Tokyo, JP), W Remme (Rhoon, NL)

12.00 Lecturer: S Mochizuki (Tokyo, JP) 143

The ISHR Australasian Section Student Symposium

THE HEART OF THE MATTER: A CAREER IN CARDIOVASCULAR RESEARCH

Chairing C Huggins (Parkville, AUS), I Williams (Sydney, AUS)

12.00 Maximising cardiac output: the key to success 144 L Opie (Cape Town, ZA)

12.30 From the lab to the lullaby: balancing a career and family 145L M D Delbridge (Melbourne, AUS)

13.00 The first few beats:developing a career in research 146 T J C Ruigrok (Utrecht, NL)

Hall Italia Hall Rossa

KEITH REIMER DISTINGUISHED LECTURE

This Award recognizes a distinguished investigator in thefield of myocardial ischemia, coronary hemodynamics,

cardiac metabolism or contractile mechanisms (including excitation-contraction coupling).

Eduardo Marbán (Baltimore, USA) 147

“Stem cells for cardiac regeneration”

Chair: R B Jennings (Durham, USA)

Hall Europa Sunday June 24, 2007 – 14.00-15.00 Hall Europa

ISHR Award

69

70

Hall Europa Sunday June 24, 2007 – 15.00-16.30 Hall Europa

Plenary Session

Organized with an unrestricted educational grant from Pfizer

THE COMPLEXITY OF DIABETES

ChairingA Consoli (Chieti, IT), P J Grant (Leeds, UK)

15.00 Why does glucose cause heart disease? 148F Cosentino (Rome, IT)

15.20 How strong is the penetration of diabetes? 149J Tuomilehto (Helsinki, FI)

15.40 How strong is the evidence of cardiovascular risk in hyperglycemia? 150A Consoli (Chieti, IT)

16.00 How best to prevent and treat diabetes? 151 S Del Prato (Pisa, IT)

Coffee Break

71

Sunday June 24, 2007 – 17.00-18.30

Frontier Symposia


HOW BEST TO CONTROL CV RISK IN DIABETES PATIENTS

Chairing S Del Prato (Pisa, IT), A Tiengo (Padua, IT)

17.00 Unmet need for glycaemic control 152G Perriello (Perugia, IT)

17.20 The important biomarkers of cardiovascular risk in diabetes 153G F Gensini (Florence, IT)

17.40 Towards an optimal glycaemic control: are there new insulin strategies? 154A Consoli (Chieti, IT)

18.00 Focus on inhaled insulin J Tuomilehto (Helsinki, FI) 155

The Cassa di Risparmio di Ferrara Symposium

ROLE OF AT2 RECEPTORS IN CARDIOVASCULAR DISEASE

Chairing A Hall (Leeds, UK), S Verma (Toronto, CA)

17.00 Cardiovascular function of AT2 receptor 156T Senbonmatsu (Saitama, JP)

17.20 The enigma of the AT2 receptor: bench to bedside 157S Verma (Toronto, CA)

17.40 Vascular AT2 receptor in hypertension 158 D Henrion (Angers, FR)

18.00 AT2 receptor gene polymorphism and cardiovascular disease 159A Hall (Leeds, UK)


72

Sunday June 24, 2007 – 17.00-18.30

Frontier Symposia


SIGNALING MECHANISMS REGULATING APOPTOSIS

Chairing A Clerk (London, UK), R N Kitsis (New York, USA)

17.00 Control of Akt phosphorylation and mitochondrial protection 160J H Brown (La Jolla, USA)

17.20 Death fold domains and apoptosis in heart failure 161R N Kitsis (New York, USA)

17.40 Bcl-2 family members and mitochondrial cell death 162L Kirshenbaum (Winnipeg, CA)

18.00 Molecular responsesto oxidant stress 163N H Bishopric (Miami, USA)


REACTIVE OXYGEN SPECIES AND CORONARY BLOOD FLOW

Chairing S Iliceto (Padua, IT), C van Echteld (Utrecht, NL)

17.00 The use of diet to improve vascular function 164G N Pierce (Winnipeg, CA)

17.20 Role of ROS in mediating flow-induced dilation 165 D Gutterman (Milwaukee, USA)

17.40 Mechanisms of ROS-mediated vascular dysfunction 166D Das (Wyandotte, USA)

18.00 Signal transduction of acute and chronic effects of ROS 167I Fleming (Frankfurt, DE)


73

Sunday June 24, 2007 – 17.00-18.30

Frontier Symposia

The Medical Trials Analysis Symposium

HEART FAILURE: WHAT DO WE HAVE UNDERSTOOD SO FAR?

Chairing R Cappato (S Donato Milanese, IT), F Zannad (Nancy, FR)

17.00 Pathophysiology of heart failure: evolution of a disease and its treatment 168 P Poole-Wilson (London, UK)

17.20 Assessment of electrical and mechanical dyssynchrony 169L Padeletti (Florence, IT)

17.40 The mechanical effect of CRT on heart failure 170D Mele (Ravenna, IT)

18.00 The prevention of sudden cardiac death in CHF worldwide guidelines 171H Klein (Magdeburg, DE)


HEART RHYTHM AND ARRHYTHMIAS

Chairing J Borer (New York, USA), M Hiraoka (Tokyo, JP)

17.00 Heart rate and repolarization: a consequential liaison? 172 A Zaza (Milan, IT)

17.20 Heart rate in the clinic: a new risk factor? 173J C Tardif (Montreal, CA)

17.40 Spontaneous calcium leaks and consequences 174K Sipido (Leuven, BE)

18.00 Clinical arrhythmias linked to calcium dysregulation 175A Oto (Ankara, TR)


74

Sunday June 24, 2007 – 17.00-18.30

Frontier Symposia

ISHR Richard J Bing Award for Young Investigators

the winner of this Award will be selected by an international panel of judges.

Chairing G Heusch (Essen, DE)

17.00 The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser-23/24 phosphorylation 176B Biesiadecki (Chicago, USA)

17.20 Regulation of troponin I phosphorylation and myofilament Ca2+ sensitivity by protein kinase D in intact ventricular myocytes 177 F Cuello (London, UK)

17.40 Preconditioning increases S-nitrosylation of the L-type Ca2+ channel and SERCA2a 178J Sun (Bethesda, USA)

18.00 Superoxide flashes in single mitochondria 179W Wang (Ann Arbor, USA)


A ROAD MAP FOR CARDIOGENESIS

Chairing G Vescovo (Vicenza, IT), T A Prolla (Madison, USA)

17.00 Cardiac development genes: importance throughout life 180D Srivastava (San Francisco, USA)

17.20 Chromatin remodeling in cardiac development 181 B G Bruneau (San Francisco, USA)

17.40 Neural crest cells: progenitors, migration and cell autonomy 182J Epstein (Philadelphia, USA)

18.00 The second heart field and its contribution to the myocardium 183M Buckingham (Paris, FR)


75

Sunday June 24, 2007 – 20.00-20.45

Hall SANTA LUCIA

LANDMARK SCIENTIFIC LECTURE

"Cardiovascular diseases: a maladaption to Societal Progress?" 184Salim Yusuf (Hamilton, CA)

Chair: N S Dhalla (Winnipeg, CA)

76

APOPTOSIS, CELL CYCLE, CELL GROWTH

Sunday June 24, 2007 – 12.30-14.00


Moderators: A Clerk (London, UK)R N Kitsis (New York, USA)

P217 SURVIVIN EXPRESSION IN THE HUMAN AORTA DURING CARDIAC SURGERY: AN EARLY NF-KAPPA B ADJUSTED STRESS SURVIVAL RESPONSEV Salpeas; I Rizos; C Rokkas; D Kremastinos; E Patsouris

P218 INVOLVEMENT OF CALCIUM SENSING RECEPTOR IN MYOCARDIALISCHEMIA/ REPERFUSION INJURY AND APOPTOSISC Xu; W Zhang; C Jiang; Y Sun; R Wang

P219S100B INDUCES MYOCYTE APOPTOSISVIA A SIGNALING PATHWAY THAT INCLUDES RAGE, ERK1/2 - p38 MAPKAND p53J N Tsoporis; S Izmar; H J Huttunen; T G Parker

P220DECREASE IN APOPTOSIS ASSOCIATED WITH CARDIOPRO-TECTIVE STRATEGIES IN A MODEL OF DONOR HEART PRESERVATION

J C Kwan; L Gao; P S Macdonald; M Hicks

P221A KINASE ANCHOR PROTEIN 121 REGULATES MITOCHONDRIAL FUNCTION AND SURVIVAL IN CARDIAC AND SMOOTH MUSCLE CELLSC Perrino; G Gargiulo; G Ambrosio; R Guerriero; M Chiariello

P222EGCG AND QUERCETIN ATTENUATEOXIDIZED LDL-INDUCED ENDOTHELIAL APOPTOSIS VIA DIFFERENTIAL MAPK-RESPONSIVE PATHWAYSY H Kang; J S Choi; Y J Choi; S W Kang; J Y Bae

P223ERYTHROPOIETIN INIHIBITS CARDIOMYOCYTE APOPTOSIS THROUGH INACTIVATION OF GLYCOGEN SYNTHASE KINASE 3βK Ohori; T Miura; M Tanno; T Miki; T Yano; Y Horio; K Shimamoto

P224ADENOSINE A2 RECEPTOR ACTIVATION PREVENTS THE MITOCHONDRIAL DEATH PATHWAY VIA A Zn2+-DEPENDENT MECHANISMZ Xu; Y Jang; H Wang; J Xi; R A Mueller; E Norfleet

P225STIMULATION OF MITOCHONDRIAL BIOGENESIS AND AUTOPHAGY BY LPSPROTECTS AGAINST APOPTOSIS IN THE RAT CARDIOMYOCYTED L Bick; C Jones; L M Buja

P226PROTECTIVE EFFECTS OF IEX-1 ONISCHEMIA/ REPERFUSION-INDUCEDCARDIAC INJURY IN THE RATSM Xu; A Qu; X Wang

P227CARDIAC APOPTOSIS AND VARIATIONS OF THE EXPOSURE TIMES TO THE SAME CUMULATIVE DOSE OF DOXORUBICINM R Vitelli; E Piegari; G Rodolico; L Leone; F Rossi; L Berrino

Moderators: G Ambrosio (Perugia, IT)M C Capogrossi (Rome, IT)

P228REGULATION OF THE EXPRESSION OF ATF3 IN CARDIAC MYOCYTES IN RESPONSE TO HYPERTROPHIC AND APOPTOTIC STIMULATIONA Giraldo; S Pikkarainen; P H Sugden;A Clerk

P229TRANSITION FROM HYPERTROPHY TO HEART FAILURE IN GUINEA PIGS

77IS ASSOCIATED WITH AN INCREASE INAPOPTOSISP K Singal; A K Sharma; S Dhingra; N Khaper

P230HUMAN FETAL CARDIAC MYOCYTE GROWTH IS MEDIATED BY ACTIVATION OF CLASS 1A/1B PI 3-KINASE,Akt, PKC, AND ERK SIGNALINGL Sandirasegarane; S K Biswas; Y Zhao; L I Sinoway

P231RHOA SIGNALING IN CARDIOMYO-CYTE SURVIVAL AND APOPTOSISD P Del Re; S Miyamoto; J Heller Brown

P232REGULATION OF CARDIOMYOCYTE GROWTH BY THE cAMP-BINDING PROTEIN EPACF Lezoualc'h; M Métrich; A Lucas; M Gastineau; E Morel

P233AKT MEDIATES CARDIOPROTECTIONTHROUGH PHOSPHORYLATION OF MITOCHONDRIAL HEXOKINASE-IIS Miyamoto; J Heller Brown

P234AKT2 REGULATES CARDIOMYOCYTESURVIVAL AND GLUCOSE METABOLISMA J Muslin; B DeBosch

P235REGULATION OF CARDIOMYOCYTE SURVIVAL BY 14-3-3τA J Muslin; J M C Lau

P236FGF-16 INTERFERES WITH FGF-2 INDUCED GROWTH IN NEONATAL CARDIAC MYOCYTESP A Cattini; S Lu

P237PRENATAL EXPOSURE TO MATERNAL LOW PROTEIN IS ACCOMPANIED BY ALTERED CELL MITOTIC INDEX IN THE POSTNATALHEARTP S Tappia; N Aroutiounova; R Fandrich;E Kardami

STEM CELLS, CELL THERAPY

Moderators: C Ventura (Bologna, IT)M Zernicka-Goetz (Cambridge, UK)

P238ULTRASTRUCTURAL ANALYSIS OF ADULT STEM CELLS EMBEDDED INTO A HYALURONAN-BASED SCAFFOLD SUITABLE FOR CARDIAC REPAIRC Gamberini; C Orrico; M Carboni; F Bonafé; L Foroni; C Guarnieri; C Muscari; G Pasquinelli

P239RESPONSES TO ENDOTHELIN IN HUMAN EMBRYONIC STEM CELL-DERIVED CARDIOMYOCYTESJ Wright; S Ahmet; S E Harding; N N Ali

P240MRI TRACKING OF SYSTEMICALLY

ADMINISTERED BONE MARROW STEM CELLSC A Carr; D J Stuckey; L Tatton; D J Tyler; S E Harding; K Clarke

P241A BIOREACTOR FOR ELECTROMECHA-NICHAL STRESS OF CELLS TO ADDRESS TOWARDS CARDIAC PHENOTYPE F Lotti; G Vassura; C Melchiorri; L Biagiotti; C Muscari; E Giordano; M Govoni; C M Caldarera; C Guarnieri; S Cavalcanti;

P242CAFFEINE-INDUCED Ca2+ SIGNALINGAS AN INDEX OF CARDIAC DIFFERENTIATIONC Altomare; L Barile; M Rocchetti; M Sampaolesi; A Giacomello; A Zaza

P243PRESERVED MICROCIRCULATION ALLOWS CARDIOMYOCYTE ENGRAFTMENT IN HUMAN SEX-MISMATCHED HEART TRANSPLANTATIONA Angelini; F Tona; C Castellani; A Gambino; A Caforio; M Della Barbera; G Gerosa; G Thiene

P244AMP-ACTIVATED PROTEIN KINASE PROMOTES THE DIFFERENTIATIONOF ENDOTHELIAL PROGENITOR CELLSX Li; Y Han; W Pang; Y Zhu

P245MOLECULAR AND FUNCTIONAL DEVELOPMENT OF CARDIOMYOCYTESDIFFERENTIATED FROM HUMAN EMBRYONIC STEM CELLSL Sartiani; E Bettiol; F Stillitano;

78A Mugelli; E Cerbai; M Jaconi

P246FETAL BOVINE SERUM IS ESSENTIALFOR CARDIAC DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLSE Bettiol; L Sartiani; L Chicha; K H Krause; E Cerbai; M Jaconi

P247EXTREMELY LOW FREQUENCY MAGNETIC FIELD INDUCES DIFFERENTIATION OF THE HUMAN CARDIAC STEM CELLS R Gaetani; M Ledda; L Barile; A Lisi; S Grimaldi; A Giacomello

Moderators: C A Beltrami (Udine, IT)M Schneider (Houston, USA)

P248MULTIPLE POTENTIAL OF SINGLE CELL-DERIVED COLONIES FROM HUMAN MESENCHYMAL STEM CELLSM M Fugarevici; A Burlacu; A Lupu; M Dorobantu

P249THERAPEUTIC FUSION : A NOVEL SOURCE OF IMMUNE-PRIVILEGE CARDIOMYOCYTES FOR CARDIAC REPAIRL Miller; R Holbova; J Leor

P2505-HT2 RECEPTORS ENABLE CARDIAC DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLSL Sartiani; F Stillitano; S Brogioni; S Suffredini; A Mugelli; E Cerbai

P251EFFECTS OF PHYSICAL FACTORS ON CARDIAC STEM CELLS

G Forte; F Carotenuto; S Pagliari; R Romano; P Cossa; F Pagliari; R Fiaccavento; P Di Nardo; M Minieri

P252DIFFERENTIAL EFFECTS OF ORGANIC NITRATES ON ENDOTHELIAL PROGENITOR CELLS ARE DETERMINED BY OXIDATIVE STRESST Thum; D Fraccarollo; M Schultheiss; A Daiber; P Wenzel; T Munzel; G Ertl; J Bauersachs

P2535-AZACYTIDINE IMPROVES THE DIFFERENTIATION OF CULTURED BONE MARROW STROMAL CELLS INTO MYOCYTESA M Rosca; A Burlacu; I Titorencu; E Dragan; M Simionescu

P254 INCREASED EXPRESSION OF BONE MARROW DERIVED ENDOTHELIAL PROGENITOR CELLS FOLLOWING EXPOSURE TO MAGNETIC FIELDS Barzelai; A Dayan; S Laniado; M Scheinowitz

P255USE OF GRANULOCYTE-COLONY STIMULATING FACTOR DURING ACUTE MYOCARDIAL INFARCTION TOENHANCE BONE MARROW STEM CELLMOBILIZATION IN HUMANSC Penzo; M Valgimigli; P Malagutti; F Merlini; L Pellegrino; R Ferrari

P256THE HEARTS OF PATIENTS WITH HEART DISEASE RETAIN PROGENITORCELLS WITH REGENERATIVE CAPACITY

A Itzhaki; J Leor; D Mishali; B Sheich Yosef; E Raanani; I M Barbash

P257EXERCISE AMELIORATES THE ADHESIVENESS OF ENDOTHELIAL PROGENITOR CELLS POST ACUTE MYOCARDIAL INFARCTIONA Dayan; G Luboshits; S Auslander; J George; M Scheinowitz

Moderators: K Fukuda (Tokyo, JP)F Quaini (Parma, IT)

P258 PATHOLOGICAL ASSESSMENT OF STEM CELL THERAPY FOR MYOCARDIAL ISCHEMIC DISEASEL M Buja; D Vela; G V Silva; Y J Geng; J T Willerson; E C Perin

P259TRANSPLANTATION OF BONE MARROW DERIVED PROGENITORS IN ACUTE MYOCARDIAL INFARCTION TWO-YEAR FOLLOW-UP R Pudil; J Vojacek; S Filip; D Vokurkova; P Mericka; J Mokry

P260TWO CELL THERAPIES TO TREAT MYOCARDIAL INFARCTION IN RATSH Mori; N Nagaya; Y Miyahara; T Fujii

P261THE HEMATOPOIETIC ACTIONS OF G-CSF IMPROVE CARDIAC FUNCTIONAND REPAIR AFTER MYOCARDIAL ISCHEMIC INJURYP Kanellakis; D Curtis; A Bobik

P262 IN VIVO DIRECT MONITORING OF STEM CELL HOMING IN POSTISCHEMIC TISSUES

79I Tritto; F Falzetti; I Porchetta; C Zuchi; E Biscottini; S Coiro; A Tabilio; G Ambrosio; M Bettini

P263ADIPOSE-DERIVED STEM CELLS SIGNIFICANTLY IMPROVE CARDIAC FUNCTION OF THE INFARCT RAT HEARTSG Tian; L Wang; J Deng; G Li; B Xiang; T Kashour; R Arora; B Tomanek; M Gruwel; M Glogowski; R Deslauriers

P264REPROGRAMMING HUMAN MONONUCLEAR CELLS TO EXPRESS CXCR4 IMPROVES HOMING AND ENGRAFTMENT IN THE INFARCTED HEARTS Netser; J Leor; H Galski; P Chouraqui; J Baron; A Nagler; I M Barbash

P265 INTRACORONARY DELIVERY OF CORD BLOOD MNCs AND CD34+

CELLS IN AN ISCHEMIA-REPERFUSIONMODELM Gaballa; J Sunkomat; D Harris

P266 IMPAIRED CONTRIBUTION OF CIRCULATING CD34+ IN MYOCARDIALISCHEMIA-INDUCED NEOVASCULA-RIZATION WITH AGEM Gaballa; H Thai; S Goldman

P267 IMPROVEMENT OF POST-INFARCTIONCARDIAC REMODELING BY GRAFTINGSTROMAL STEM CELLS WITH A

HYALURONAN-BASED SCAFFOLDM Carboni; M Tsivian; G Arpesella; L Foroni; E Fiumana; G Pasquinelli; B Nardo; C M Caldarera

Moderators: C Muscari (Bologna, IT)J T Willerson (Houston, USA)

P268ELECTRICAL COMPETENCE OF INFARCTED HEART FOLLOWING STEM CELL BASED REGENERATIVE THERAPY, IN A RAT MODELE Musso; L Bocchi; M Savi; R Berni; G Graiani; C Lagrasta; F Quaini

P269MESENCHYMAL STEM CELLS SUPERNATANT PROTECTS CARDIOMYOCYTES FROM DEATH INDUCED BY HYPOXIA AND REOXYGENATIOND Angoulvant; F Ivanes; R Ferrera; V Guyot; O Gateau-Roesch; M Ovize

P270NON-INVASIVE MONITORING OF IN SITU OXYGENATION AND FUNCTIONAL RECOVERY IN INFARCT HEARTS TRANSPLANTED WITH SKELETAL MYOBLASTSP Kuppusamy; M Khan; V K Kutala

P271ROLE OF THE STEM CELL ANTIGEN-1 (SCA-1) IN THE MAINTENANCE OF RESIDENT CARDIAC PRECURSORS

N Rosenblatt-Velin; S Ogay; A Felley; A Domenighetti; M Lepore; T Pedrazzini

P272SKELETAL MYOBLASTS AND BONE MARROW CELLS ENHANCE CONTRACTILITY OF FAILING CARDIOMYOCYTES IN CO-CULTUREJ Lee; U Siedlecka; M Stagg; G Soppa; M Yacoub; C M N Terracciano

P273CARDIAC STEM CELLS CAN BE GENERATED IN DAMAGED HEART FROM BONE MARROW-DERIVED CELLS L Barile; F Cerisoli; R Gaetani; E Forte; S Ottolenghi; M C Magli; E Messina

P274DIFFERENTIATION POTENTIAL OF CARDIAC STEM AND PROGENITOR CELLS IN A MODEL OF HETEROTOPICHEART TRANSPLANTATION S Ausoni; T Zaglia; S Bracco; A Dedja; E Cozzi; S Schiaffino

P275STEM CELLS RECRUITMENT IN HUMAN RIGHT VENTRICULAR REMODELINGA Angelini; C Castellani;M Della Barbera; S Toffoli; M Padalino; O Milanesi; G Stellin; G Thiene

P276A PROGNOSTIC INDICATOR FOR LIMB AMPUTATION AFTER BONE MARROW MONONUCLEAR CELLS IMPLANTATIONS Tara; G Takagi; K Kato; H Takano; I Takagi; M Yasutake; M Miyamoto; T Takano

80

MYOCARDIAL PHYSIOLOGY AND PATHOPHYSIOLOGY

Moderators: G Baxter (Cardiff, UK)G Vescovo (Vicenza, IT)

P277ACUTE DECLINE IN PERFUSATE MgCONTENT MODULATES NEUROPEPTIDE AND CYTOKINE RELEASE FROM Mg-NORMAL RAT HEARTSJ H Kramer; I T Mak; W B Weglicki

P278ALDOSTERONE PREVENTS DELETERIOUS EFFECTS OF DIABETES IN MOUSE HEARTSS Messaoudi; P Milliez; J L Samuel; C Delcayre

P279FEEDFORWARD NEURAL REGULATION OF CIRCULATION IN CONSCIOUS RATS J M Legramante; S Sacco; R Fiaccavento; P Di Nardo; G Raimondi; M Pallante; A Galante

P280SYSTEMIC CAPSAICIN PRETREATMENT MODULATES MYOCARDIAL OXIDATIVE AND NITROSATIVE STRESSP Bencsik; A Gorbe; T Csont; G Jancso;S Furst; P Ferdinandy;

P281ADAPTATION OF BAROREFLEX TO CAROTIS STIFFENING IN TRANSPOSITION OF THE GREAT

ARTERIESA Pinter; A Laszlo; B Mersich; K Kádár; M Kollai;

P282 ISOPROTERENOL WASHOUT-INDUCED DETERIORATION OF CARDIAC CONTRACTILITY IS ATTENUATED BY INTRACELLULAR MAGNESIUMM Watanabe; M Sakurai; T Sato; A Kurisaki; J Wu; T Okada;

P283THE RESTORATIVE EFFECT OF ANPOR CHRONIC NEP INHIBITION ON BLUNTED CARDIAC VAGAL REFLEXES IN AGED RATSC J Thomas; R L Woods;

P284INTERMITTENT HYPOXIA REGULATESTHE RENIN-ANGIOTENSIN SYSTEM IN THE RAT CAROTID BODYS S Y Lam; M L Fung; G L Tipoe; E C Liong; Y W Tjong;

P285CARDIOVASCULAR RHYTHMS AND HEART-LUNG COUPLINGL Shen; Y Cao; D Tang; D Zheng; G Wu;

P286CALPAIN AND MITOCHONDRIAL DYSFUNCION IN Ca2+ OVERLOADED CARDIOMYOCYTESA Carpi; R Venerando; G Miotto; D Bertaggia; F Di Lisa;

P287 INCREASED TRANSSARCOLEMMAL CALCIUM FLUX AND MYOFILAMENTRESPONSIVENESS IN CARDIOMYO-

CYTES FROM SERCA2null MICEW E Louch; J A Birkeland; K B Andersson; I Sjaastad; H K Mørk; O M Sejersted; G Christensen;

Moderators: N S Dhalla (Winnipeg, CA)B Ostadal (Prague, CZ)

P288NRG-1 MODULATION OF CONTRAC-TILITY AND NO SYNTHESIS IN ISOLATED VENTRICULAR MYOCYTESA Brero; R Ramella; C Dati; G Alloatti; M Gallo; R Levi;

P289HEART FUNCTION IN ADULT CARDIAC Serca2null MICEK B Andersson; A V Finsen; I Sjaastad; J Chen; Y Wang; J D Molkentin; K R Chien; O M Sejersted; G Christensen;

P290MYOCARDIAL DYSFUNCTION WITH REDUCED SODIUM-CALCIUM EXCHANGER EXPRESSIONM C Jordan; S A Henderson; T Han; K D Philipson; K P Roos;

P291STRETCH-MEDIATED CHANGES IN INTRACELLULAR Ca2+ IN ISOLATED MOUSE MYOCARDIUMM L Ward; D G Allen;

P292CALCIUM FLUX IN TURTLE VENTRICULAR MYOCYTESG L J Galli; E W Taylor; H A Shiels;

81P293 IMPORTANCE OF MYOSIN HEAVY

CHAIN ISOFORM EXPRESSION AS A DETERMINANT OF CONTRACTION KINETICS IN PIG MYOCARDIUMM R Locher; M V Razumova; J E Stelzer; R L Moss;

P294ACTOMYOSIN INTERACTIONS IN cMYBP-C-/- MICEY Lecarpentier; N Vignier; P Oliviero; A Guellich; M Cortès-Morichetti; L Carrier; C Coirault;

P295CONTRIBUTION OF ATP SYNTHASE TO STIMULATION OF RESPIRATION BY Ca2+ IN HEART MITOCHONDRIAR Baniene; Z Nauciene; V Mildaziene;

P296 IN VIVO DEGRADATION OF NITRIC-OXIDE SYNTHASE ISOZYMES BY CALPAIN IS REGULATED BY HSP90E Melloni; M Averna; R Stifanese; R De Tullio; F Salamino; S Pontremoli;

Moderators: J H Brown (La Jolla, USA) R Schulz (Essen, DE)

P297 MITOCHONDRIAL PERMEABILITY TRANSITION PORE INDUCES HYPERCONTRACTURE IN Ca2+

OVERLOADED CARDIAC MYOCYTESM Ruiz-Meana; D Garcia-Dorado; A Abellan; E Miro-Casas;

P298NITROXYL: A POSITIVE INOTROPE ENHAHCING SR Ca2+ CYCLING IN ISOLATED MYOCYTES

C Tocchetti; J Froehlich; H Valdivia; M Aon; N Kaludercic; S Betocchi; M Chiariello; N Paolocci;

P299SEX DIFFERENCES AFFECT Ca2+

SPARKS PARAMETERS IN NORMAL AND DIABETIC RAT VENTRICULAR CARDIOMYOCTESB Turan; N Yaras; E Tuncay; N Purali; B Sahinoglu; A Lacampagne; G Vassort;

P300SEX RELATED DIFFERENTIAL EFFECTS OF OMEGA-3E TREATMENTON DIABETES-INDUCED LEFT VENTRICULAR DYSFUNCTIONE Tuncay; A Seymen; E Tanriverdi; N Yaras; B Turan;

P301ENHANCED Ca2+ TRANSIENT AND CELL CONTRACTILITY IS ASSOCIATEDWITH DECREASED Cx43 IN β1-ARG389 MICEI Bodi; K D'Souza; S B Liggett; A Schwartz;

P302TEMPOL, A Mn-SOD MIMETIC, PREVENTS THE CARDIAC CONTRACTILE DYSFUNCTION IN PPARalpha -/- MICE A Guellich; T Damy; Y Lecarpentier; P Oliviero; F Marotte; T Pineau; C Coirault;

P303VASOSTATIN-1EFFECTS ON MYOCARDIAL CONTRACTILITY ANDCARDIOPROTECTIONM C Cerra; T Angelone; S Cappello; R Rastaldo; A M Quintieri; E Pulerà; P Pagliaro; B Tota; G Losano;

P304HEMODYNAMIC EFFECTS OF THE INTRACORONARY ADMINISTRATIONOF UROCORTIN 2 IN THE ANESTHETIZED PIGE Grossini; P P Caimmi; C Molinari; G Teodori; G Marino;

P305CONVERSION OF POSTSYSTOLIC INTO EJECTIONAL WALL THICKENINGBY SELECTIVE HEART RATE REDUCTION DURING STUNNING B Ghaleh; L Lucats; X Monnet; P Colin; A Bize; A Berdeaux;

P306PATHOPHYSIOLOGICAL BACKGROUND CONTRIBUTING TO SWIFT NORMALIZATION OF CARDIAC GEOMETRY AND FUNCTION DESPITE DIAGNOSED ONCE AS DILATED CARDIOMYOPATHYT Inomata; H Shinagawa; T Osaka; T Koitabashi; H Takehana; T Izumi;

P307REDUCED MYOCARDIAL CALCIUM RESPONSIVENESS AFTER CORONARYMICROEMBOLIZATIONA Skyschally; P Gres; P Van Caster; R Schulz; F Di Lisa; G Heusch;

Moderators: M Marber (London, UK)R Mohanlal (Boston, USA)

P308 INTERACTION OF A CARDIAC MUSCLE AND ITS MATHEMATICAL MODEL IN HYBRID DUPLEXO N Lookin; W Y Gur'ev; S Routkevitch; A A Balakin;

P309COMPARISON OF GRAFTS WAVEFOMIN CORONARY ARTERY BYPASS

82GRAFTING BY USING A FAST FOURIER TRANSFORMATION ANALYSIS M Kaneko; A Hatada; T Yoshimasu; M Kawago; Y Iwahashi; Y Nishimura; T Hiramatsu; Y Okamura;

P310 INOTROPIC AND LUISITROPIC BIOMARKERS IN THE RAT LANGENDORFF PREPARATIONE Andrag; M J Curtis;

P311KATP CHANNEL BLOCKADE TRANSFORMS ADULT CARDIAC PROTECTIVE STRESS RESPONSE TO AN AGED PHENOTYPES Sagar; C Cabrera Aguilera; A Oberlin; A Terzic; A Jahangir;

P312SUPPORT FOR A TRIMERIC COLLAR OF MYOSIN BINDING PROTEIN C IN CARDIAC AND FAST, BUT NOT SLOW, SKELETAL MUSCLEJ C Moolman-Smook; E Flashman; L Korkie; C Redwood; H Watkins;

P313DECREASED NEUTRAL ENDOPEPTIDASE (NEP) ACTIVITY IN CARDIAC NEUROGENIC INFLAMMATION DUE TO MAGNESIUM DEFICIENCYJ J Chmielinska; I T Mak; J H Kramer;K Viswalingam; W B Weglicki;

P314A POTENTIAL MOLECULAR MECHANISM FOR DIGITALIS CARDIAC TOXICITY IN ELDERLYM Yousufuddin; C Cabrera Aguilera; A Oberlin; S Sagar; A Jahangir;

P315CRYOINJURY TO PIG HEART: NEAR-INFRARED SPECTROSCOPIC IMAGING STUDY (NIRS)V Kupriyanov; E Gussakovsky; D Manley; Y Yang; O Jilkina;

P316THE EFFECT OF PANAXADIOL SAPONINS ON AQP1 EXPRESSION INMYOCARDIAL TISSUES IN ENDOTOXIC SHOCK RATSJ Cao; X Liu; J Zhang; B Yang; X Zhao;

P317PROGRESSIVE HEART BLOCK IN MICE LACKING UREA TRANSPORTERUT-BY Meng; X Zhang; L Guo; C Zhao; X Zhao;B Yang;

P318PHOSPHODIESTERASE ACTIVITY INISOLATED CARDIOMYOCYTES FROMRAT, GUINEA PIG AND HUMAN HEARTW B Johnson; S Katugampola; C Napier; S E Harding;

Moderators: N H Bishopric (Miami, USA)G N Pierce (Winnipeg, CA)

P319 FATTY ACID COMPOSITION OF HUMAN HEART : SETTING THEBASELINEM L Theiss; P L McLennan; F Sheeran; S Pepe;

P320REGULATION OF MATRIX METALLOPROTEINASE-2 IN THE HEART BY CAVEOLIN-1A K Chow; J Cena; A F El-Yazbi; B D Crawford; A Holt; W J Cho;

E E Daniel; R Schulz;

P321THE CYCLOPHILIN-D BINDING PROTEIN OF THE MITOCHONDRIALPERMEABILITY TRANSITION PORE MAY NOT BE THE ADENINE NUCLEOTIDE TRANSLOCASEA W C Leung; A P Halestrap;

P322TOTAL ANTIOXIDANT CAPACITY ANDOXIDATIVE DAMAGE TO PROTEINS AND LIPIDS IN AGED RAT HEARTP Kaplan; M Sivonova; Z Tatarkova; E Babusikova; J Lehotsky; D Dobrota;

P323TROPONIN I DEFICIENCY CAUSES IMPAIRED CARDIAC RELAXATION AND HEART FAILURE IN MICEX Huang; J Liu; J Du; J W Walker; C Zhang;

P324RADIAL DISPLACEMENT OF MYOSIN CROSS-BRIDGES IN MOUSE MYOCARDIUM DUE TO ABLATION OF MYOSIN BINDING PROTEIN-CB A Colson; T Bekyarova; D P Fitzsimons;T C Irving; R L Moss

P325TROPOMYOSIN AND REACTIVE NITROGEN SPECIESM Canton; S Menazza; R Menabò; F Di Lisa;

P326ALPHA SKELETAL ACTIN EXPRESSION IN DEDIFFERENTIATINGCARDIOMYOCYTESR B Driesen; F K Verheyen; C Chaponnier; E Blaauw; F A Babiker; M H Lenders; M Borgers; F C S Ramaekers;

83P327ACTIN BINDING PROPERTIES OF

CARDIAC MYOSIN BINDING PROTEIN-C I N Rybakova; R L Moss;

P328RESTORING FORCE IS LOWER IN HUMAN DONOR AND HCM MYOCYTES COMPARED WITH RATA C Hoskins; A M Jacques; S B Marston; J C Kentish;

P329 IDENTIFICATION OF CX43 IN MITOCHONDRIAL MEMBRANES BY MASS SPECTROMETRY D Garcia-Dorado; A Rodríguez-Sinovas; I Jorge; E Miró; A Cabestrero; M Ruiz-Meana; J Vázquez; G Heusch; M Morente;

Moderators: E G Kranias (Cincinnati, USA)G D Lopaschuk (Edmonton, CA)

P330MITOCHONDRIAL CONNEXIN 43 HEMICHANNELSM Ruiz-Meana; E Miro-Casas; I Torre; E Agullo; M Morente; A Cabestrero; A Rodriguez-Sinovas; R Shulz; K Boengler; G Heusch; D Garcia-Dorado

P331MODULATION OF MECHANICAL PROPERTIES OF THE INTERACTIONS

BETWEEN FIBRONECTIN AND α5β1-INTEGRIN ON CARDIOMYOCYTESM Muthuchamy; X Wu; Z Sun; J P Trzeciakowski; G A Meininger;

P332CARDIAC CYTOSKELETON IS MODULATED BY HUMAN RECOMBINANT VASOSTATIN 1T Angelone; R Mazza; C Mannarino; E Filice; S Barbieri; Y Goumon; G Zummo; M H Metz-Boutigue; B Tota;

P333THE RATE OF LOSS OF T-TUBULES IN CULTURED ADULT VENTRICULARMYOCYTES IS SPECIES-DEPENDENTD Pavlovic; L M McLatchie; M J Shattock;

P334ELECTRON TOMOGRAPHY REVEALS THE STRUCTURE OF THE C-ZONE INSTRIATED MUSCLEP Luther; H Winkler; K Taylor; R Craig; R Padron; J Liu;

P335CONNECTIVE TISSUE GROWTH FACTOR (CTGF) INHIBITS MYOCARDIAL GROWTH, BUT PRESERVES MYOCARDIAL FUNCTIONM S Ahmed; T Lueder; J A Gravning; T Edvardsen; E Oie; O A Smiseth; H Attramadal;

P336NEONATAL AND ADULT VENTRICULARMYOFIBROBLASTS DISPLAY A SYNTHETIC AS WELL AS A CONTRACTILE PHENOTYPEA L Dangerfield; J Santiago; K L Bathe; S G Rattan; E Kardami; I M C Dixon;

P337ESSENTIAL ROLES OF CONSTITUTIVEAUTOPHAGY IN QUALITY CONTROLOF PROTEINS IN THE HEARTSH Akazawa; C Liao; Y Kudo; S Kudoh; I Komuro;

P338AUTOPHAGY IN CARDIOMYOCYTE ISESSENTIAL FOR MAINTENANCE OF CARDIAC FUNCTION AND RESPONSETO EXTERNAL STRESS S Hikoso; A Nakai; O Yamaguchi; N Mizushima; K Otsu; M Hori;

P339PROTEASOME HETEROGENEITY IN CARDIAC TISSUEO Drews; C Zong; X Li; A V Gomes; Z Li; G Young; P Ping;

P340STRUCTURAL AND FUNCTIONAL MODELLING OF THE ACTIN/ESSENTIALMYOSIN LIGHT CHAIN INTERACTIONIN THE HEARTI Morano; E M Aydt; H Haase; G Tünnemann; C Cardoso; G Wolff;

84

HYPERTENSION

Moderators: C Borghi (Bologna, IT)F Zannad (Nancy, FR)

P341 IDENTIFICATION OF MICRORNAS, INFLAMMATORY CYTOKINE AND RECEPTOR GENES EXPRESSION IN SPONTANOUS HYPERTENSIONZ Shan; X Yu; Q Lin; Y Fu; C Deng; S Lin;

P342RED WINE POLYPHENOLS PREVENT CARDIO-VASCULAR ALTERATIONS IN HYPERTENSIONO Pechanova; I Bernatova; S Kojsova; L Jendekova;

P343THE MECHANISM OF APOCYNIN - INDUCED PREVENTION OF HYPERTENSION O Pechanova; L Jendekova; S Kojsova;

P344MYOCARDIAL AND KIDNEY

HISTOLOGICAL - ULTRASTRUCTURALCHANGES IN RATS WITH FRUCTOSE-INDUCED HYPERTENSIONE Romero-Vecchione; M Strauss; F Rosa; J Vásquez; R Antequera; A Pinto;

P345EFFECT OF CHRONIC CROWDING ONPLASMA CORTICOSTERONE IN RATS WITH GENETIC PREDISPOSITION TOHYPERETENSIONI Bernatova; A Puzserova; Z Csizmadiova; M Zeman;

P346EFFECT OF RED WINE POLYPHENOLS ON VASORELAXATIONOF NORMOTENSIVE AND BORDERLINE HYPERTENSIVE RATSI Bernatova; A Puzserova; R Andriantsitohaina;

P347EFFECT OF RED WINE POLYPHENOLSON BLOOD PRESSURE AND VASORELAXATION OF WISTAR-KYOTO

RATS EXPOSED TO CHRONIC STRESSI Bernatova; A Puzserova; R Andriantsitohaina;

P348STAGE OF OBESITY AND COMBINED THERAPY OF ARTERIAL HYPERTENSION M Postula; A Niebisz; M Jasik; B Tarchalska; W Karnafel;

P349MODULATION OF CARDIAC RESPONSETO ISCHEMIA/REPERFUSION IN HYPERTENSIVE RATS EXPOSED TO CHRONIC SOCIAL STRESST Ravingerova; J Matejikova; I Bernatova;

P350COENZYME Q10 IN THE TREATMENTOF HYPERTENSION: A META-ANALYSISOF THE CLINICAL TRIALSF L Rosenfeldt; S J Haas; H Krum; A Hadj; K Ng; J Y Leong; G F Watts;

85

HYPERTROPHY

Moderators: E Giordano (Bologna, IT)A Toker (Boston, USA)

P351DECREASED PHOSPHODIESTERASE ACTIVITIES IN CARDIAC HYPERTROPHY: CONSEQUENCES FOR ß-AR REGULATION OF cAMP AND ICa,L

G Vandecasteele; A Abi-Gerges; L R V Castro; J Leroy; C Heymes; J L Samuel; C Lugnier; R Fischmeister;

P352ALTERED BALANCE BETWEEN MMPs AND TIMPs IN A MODEL OF CONGENITAL BIVENTRICULAR HYPERTROPHYS Bleiziffer; J Grammer; C Schreiber; S Fratz; S Naumann; J Hess; R Lange; R Bauernschmitt;

P353FGF-2 EXPORTED FROM CARDIAC FIBROBLASTS MAY ACT BOTH SYSTEMICALLY AND LOCALLY DEPENDING ON ISOFORM COMPOSITIONJ Santiago; R Fandrich; E Kardami;

P354DELETION OF PPARα RESULTS IN MORE PRONOUNCED CARDIAC HYPERTROPHY IN RESPONSE TO CHRONIC PRESSURE OVERLOADP J H Smeets; P H Willemsen;A E Brouns; B J Janssen;

G Van Der Vusse; M Van Bilsen;

P355DIFFERENTIAL REGULATION OF COMPONENTS OF THE AM/IMD RECEPTOR SYSTEM IN NITRIC OXIDE-DEFICIENT CARDIOMYOCYTESY Zhao; D Bell; F McCoy; B McDermott;

P356CAPTOPRIL IMPROVES MCT-INDUCED RAT RIGHT VENTRICULAR HYPERTROPHY THROUGH INHIBITION OF MATRIX METALLOPROTEINASESY Hara; H Naruse; K Kizaki; M Okada; H Yamawaki;

P357AKT AS A MEDIATOR OF THE HYPERTROPHIC EFFECT OF INCREASED NHE1 ACTIVITYA Darmellah; D Baetz; F Prunier; S Tamareille; C Rücker-Martin; D Feuvray;

P358CARDIAC HYPERTROPHY INDUCED BY PRESSURE OVERLOAD IS MEDIATED BY LIF/STAT3 ACTIVATIONL Comini; L Schiaffonati; A Angelini; R Ferrari;

P359ADIPONECTIN-MEDIATED SIGNAL PATHWAY WAS SUPPRESSED IN CARDIAC HYPERTROPHYRL Wu; L Li; C Wang; F Fu;

P360AT1 RECEPTOR PARTICIPATES IN RESISTANCE-TRAINING-INDUCED CARDIAC HYPERTROPHY IN RATS

V G Barauna; K T Rosa; M C Irigoyen; E M Oliveira;

P361NOVEL BIOACTIVE PEPTIDES ATTENUATE PHENYLEPHRINE-INDUCED ACTIVATION OF RAS IN ISOLATED RAT CARDIOMYOCYTESN Prairie; H Li; R Aluko; P S Tappia;

Moderators: B G Bruneau (San Francisco, USA)A Hall (Leeds, UK)

P362ELEVATED LEVELS OF PHOSPHORYLATED AKT IN HYPERTROPHY PRE-DESTINED NEONATAL HEARTSE R Porrello; J D Schertzer; C L Curl; G S Lynch; S B Harrap; W G Thomas; L M D Delbridge;

P363DOMNEG FOS (AFOS) IMPROVES CARDIAC MYOCYTE FUNCTION IN PATHOLOGIC HYPERTROPHY IN VITROC S Long; M Y Jeong;

P364NONSENSE-MEDIATED mRNA DECAY DEGRADES cMyBP-C MUTANTS IN CARDIOMYOPATHIC MICES Schlossarek; N Vignier; G Mearini; J Guiard; K Schwartz; M Vernet; T Eschenhagen; L Carrier;

P365UPREGULATION OF INTERMEDIN AND REDUCED NEUTRAL

86ENDOPEPTIDASE EXPRESSION IN HYPERTENSIVE CARDIAC HYPERTROPHYB McDermott; Y Zhao; F McCoy; D Bell;

P366 INDUCTION OF CARDIOMYOCYTE HYPERTROPHY BY SPECIFIC KNOCKDOWN OF AN A-KINASE ANCHOR PROTEINM P Czubryt; M A AlShaaban; B Abrenica;

P367NOTCH SIGNALLING: A POTENTIAL REGULATOR OF CARDIAC RESPONSETO HYPERTROPHIC STIMULIM Nemir; N Jordan; A Croquelois; A Domenighetti; T Pedrazzinin;

P368VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOAD IS ASSOCIATED TO IMPAIRED CD4 CD8RECRUITMENT IN DIABETIC MICEF Borgia; M C De Angelis; E Capasso; A Rapacciuolo; M Chiariello;

P369SOME MITOCHONDRIAL EVENTS IN PRESSURE OVERLOAD INDUCED CARDIAC HYPERTROPHY-FROM GENE TO FUNCTIONJ Liu; Y Zhao; J Li; L Xu; H Liu; J Xu; L Chen;

P370MYOCYTE HYPERTROPHY IN RESPONSE TO PHENYLEPHRINE IS INHIBITED BY BLOCKADE OF NUCLEAR IMPORT OF MUSCLE LIM PROTEINS Y Boateng; S E Senyo; B Russel;

P371MICROTUBULAR TRANSPORT

FUNCTION IS ESSENTIAL FOR NORMAL AND HYPERTROPHIED CARDIOCYTED Scholz; G Cooper;

Moderators: G Béréziat (Paris, FR)R Willette (King of Prussia, USA)

P372METABOLIC AND FUNCTIONAL RESPONSE OF FAILING HEART TO ADRENERGIC STIMULATION FOLLOWING SERCA1 OVEREXPRESSIONJ M O'Donnell; A Fields; X Xu; E D Lewandowski;

P373GLYCOSIDE-INDUCED HYPERTROPHYIS ASSOCIATED WITH SELECTIVE Na+-K+ ATPase ISOFORM DOWNREGULATION ROLE OF NHE-1X T Gan; J Xue; C X Huang; M Karmazyn;

P374THE SARCOLEMMAL CALCIUM PUMP (PMCA4B) IS INVOLVED IN THE DEVELOPMENT OF PRESSURE OVERLOAD INDUCED HYPERTROPHYM Zi; D Oceandy; S Prehar; E J Cartwright; L Neyses;

P375Ca2+ HANDLING IN A GUINEA-PIG HYPERTROPHY/FAILURE MODELM Rocchetti; P Barassi; M Alemanni; G Mostacciuolo; P Ferrari; A Zaza;

P376DECREASED HYPERTROPHY AND CONTRACTILE DYSFUNCTION IN

MICE FED A HIGH STARCH DIET FOLLOWING AORTIC CONSTRICTIOND J Chess; W C Stanley;

P377THE EFFECT OF LOW DOSE TUNA FISH OIL ON CARDIAC HYPERTROPHYAND MEMBRANE FATTY ACID COMPOSITION IN THE RAT HEART R Henry; P L McLennan; G E Peoples;

P378PHENYLEPHRINE INDUCED HYPERTROPHY IN NEONATAL CARDIAC MYOCYTES IS MODULATED BY TESTOSTERONER Patel; R H Ritchie; I R Wendt;

P379TESTOSTERONE MODULATES PHYSIOLOGICAL CARDIAC HYPERTROPHYR Patel; R H Ritchie; C L Curl; L M Delbridge; I R Wendt;

P380Na+/H+ EXCHANGER OVER-EXPRESSING MICE EXHIBIT HYPERTROPHY AND ELEVATED RESPONSE TO PHENYLEPHRINEF Mraiche; T Gan; M Karmazyn; L Fliegel;

P381ALTERED EXPRESSION OF MYOCARDIAL Ca2+ HANDLING PROTEINS IN EXPERIMENTAL URAEMIAD Aksentijevic; K Y Lee; K Smith; S Bhandari; A L Seymour;

P382COOPERATION BETWEEN RECEPTOR- AND MONOAMINE OXIDASE-DEPENDANT PATHWAYS IN CARDIAC HYPERTROPHY BY SEROTONIN

87J Mialet-Perez; N Pizzinat; C Ordener; A Parini;

Moderators: M Olthof (Amsterdam, NL)F Visioli (Paris, FR)

P383 IMPACT OF 9 WEEK HIGH-FAT DIET ON CARDIAC HYPERTROPHYA Akki; A L Seymour;

P384FISH OIL INCREASES ADIPONECTIN AND PREVENTS LEFT VENTRICULAR REMODELING IN PRESSURE OVERLOAD HYPERTROPHYM K Duda; K M O'Shea; T A McElfresh; B D Hoit; W C Stanley;

P385DOXYCYCLINE ACCELERATES LEFTVENTRICULAR HYPERTROPHY ANDPROGRESSION TO HEART FAILURE AFTER THORACIC AORTA CONSTRICTION IN MOUSEL Vinet; P Rouet-Benzineb; M Heimburger; J Mercadier;

P386APELIN IN DIABETIC AND HYPERLI-PIDEMIC CARDIAC DYSFUNCTIONG Foldes; E Ruzicska; M Ilves; M Toth; H Ruskoaho;

P387HIGH SUGAR DIET ADVERSELY EFFECTS GENE EXPRESSION, CARDIAC FUNCTION AND SURVIVAL WITH PRESSURE OVERLOADB R Barrows; N Sharma; A M Azimzadeh; H Sabbah; V Sharov; W Stanley;

P388CARDIOMYOCYTE HYPERTROPHY INMOUSE MODELS OF TYPE II DIABETES AND THE METABOLIC SYNDROMEI Nevelsteen; A Van Den Bergh; P Herijgers;

P389 INFLUENCE OF ENDOTHELIAL NOX2 NADPH OXIDASE ON ANGIOTENSIN II-INDUCED CARDIAC HYPERTROPHY AND REMODELLINGC E Murdoch; M Zhang; D Grieve; A Siva; A Brewer; A M Shah;

P390EXERCISE INDUCED CARDIAC HYPERTROPHY PROVIDES PROTECTION AGAINST PRESSURE OVERLOADJ R McMullen; X Gao; H Kiriazis; X Du; K A Hewitt; J P Mollica;

P391MYOCARDIAL INFARCTION IN MICEINDUCES HYPERTROPHY AND HEART FAILURE WITHOUT REDUCED CONTRACTION OF VIABLE MYOCYTES H K Mørk; I Sjaastad; O M Sejersted; W E Louch;

P392ALTERED MYOFILAMENT PROPERTIES IN PATIENTS WITH AORTIC STENOSISD W Maughan; T Suzuki; M M LeWinter; P VanBuren; B M Palmer;

P393HYPERTENSION, CARDIAC HYPERTROPHY AND HEART FAILU-RE: IS THERE A ROLE FOR N-3 PUFAs?A Bordoni; A Astolfi; R Leghissa; L Morandi; A Pession; F Danesi; M Di Nunzio; A Pession;

88

LEFT VENTRICULAR DYSFUNCTION AND HEART FAILURE

Moderators: C Ceconi (Ferrara, IT)P Poole-Wilson (London, UK)

P394βARK1-DIRECTED β2-ADRENERGIC RECEPTOR COUPLING TO GI

SIGNALING LEADS TO HEART FAILUREW Zhu; K Chakir; W J Koch; R P Xiao;

P395CYTOCHROME C RELEASE IN CARDIOMYOCYTES OF PULMONARYHYPERTENSIVE RATSW J Van Der Laarse; B J Van Beek-Harmsen; H M Feenstra;

P396CARDIAC NEUROHUMORAL CONTROL DURING EARLY AND LATESTAGE OF HEART FAILURE IN 2α/α2C ADRENOCEPTOR KO MICEJ C B Ferreira; F S Evangelista;A V Bacurau; E M Oliveira;

J E Krieger; P C Brum;

P397PHOSPHORYLATION DEPENDENT TARGETING OF CONNEXIN 43 TO LIPIDRAFTS IS INCREASED IN HEART FAILUREG G Hesketh; M Shah; Y Guo; G F Tomaselli; J E Van Eyk;

P398PROTEOMICS ANALYSIS OF LEUKOCYTE MEMBRANE PROTEINSFROM HUMAN HEART FAILURE PATIENTS USING AN ANTIBODY

MICROARRAY PLATFORMR Lui; P S Macdonald; C Hayward; C G Dos Remedios;

P399ET-1 AND ET-1 RECEPTORS: ETA

AND ETB GENE EXPRESSION IN THE HEART DURING END-STAGE HFM Szperl; M Roszczynko; P Kolsut; Z Bilinska; W Ruzyllo;

P400FOLLISTATIN GENE EXPRESSION ISELEVATED IN HEART FAILURE AND DECREASES FOLLOWING RECOVERYE Lara-Pezzi; L E Felkin; E Birks; M H Yacoub; N Rosenthal; P J Barton;

P401MYOCARDIAL REMODELLING AND CHANGES IN THYROID HORMONE RECEPTOR α-1 EARLY AND LATE AFTER MYOCARDIAL INFARCTION IN RATSI Mourouzis; C Xinaris; K Markakis;M Panagiotou; C Tesseromatis; C Pantos; D V Cokkinos;

P402THYROID HORMONE ATTENUATES CARDIAC REMODELING AND IMPROVES HAEMODYNAMICS EARLY AFTER MYOCARDIAL INFARCTION I Mourouzis; K Markakis; A Dimopoulos; C Xinaris; M Panagiotou; C Pantos; D V Cokkinos;

P403POST-MYOCARDIAL INFARCTION EXERCISE TRAINING AND MYOCARDIAL FIBROSISJ Q Zhang; W Wan; L Ji; A S Powers;

B Wilson; Y Sun;

P404ROLE OF UROTENSIN II SIGNALINGIN CARDIAC REMODELING

F Borgia; M C De Angelis; M Petretta; G Esposito; M Chiariello;

P405 IMPLANTATION OF A MICROAXIAL FLOW PUMP IN A PIG MODEL OF HEART FAILURE: HEMODYNAMIC AND MORPHOLOGIC EFFECTSS Voss; H Moellmann; H Nef; M Lintz; C Oltenau; C Troidl; A Elsaesser;

Moderators: D Mele (Ravenna, IT)H Sisakyan (Yerevan, AM)

P406PROTECTIVE ROLE OF ENDOGENOUS ERYTHROPOIETIN SYSTEM AGAINST PRESSURE OVERLOAD-INDUCED LV DYSFUN-CTION THROUGH CORONARY ANGIOGENESISY Asaumi; Y Kagaya; M Takeda; N Minegishi; H Shimokawa;

P407 IDENTIFICATION OF SEX-SPECIFIC TARGETS IN POST-MI REMODELINGM Bauer; G Mitterer; W Dietl; K Trescher; W M Schmidt; B K Podesser;

P408CORRELATION BETWEEN HEART FUNCTIONS AND PROTEIN LEVELS IN THE RAT CHRONIC HEART FAILURE

89Y Sanzen; Y Ohta; T Kawada; H Sato; Y Yoshida; Y Nagasaka; T Yamamoto; M Nakazawa;

P409REDUCTION OF HEMOGLOBIN-OXYGEN AFFINITY IMPROVES EXERCISE CAPACITY IN MICE WITH CHRONIC HEART FAILURES Hikoso; T Watanabe; K Otsu; M Hori;

P410ENHANCED OXIDANT STRESS UNDER ACUTE HEART FAILURE EXACERBATES CARDIAC REMODELING AT ITS STABLE PHASEY Kijima; M Kunishige; T Sakai; O Akutagawa; A Matsuo; A Nishibe; Y Nakagawa; T Hata;

P411AGE-RELATED DIFFERENCES IN POST-INFARCT CARDIAC RUPTURE AND LV REMODELING ASSOCIATED WITH MMPs ACTIVATIONY N Yang; W Han; J Li; Y Xiang; F Liu; X Ma; J F Zhang; Z Fu; Y T Ma; X J Du; X M Gao

P412ENDOGENOUS ENDOSTATIN ATTENUATES POSTINFARCTION VENTRICULAR REMODELING BY INHIBITING MATRIX METALLOPROTEINASE ACTIVITYK Isobe; Y Maejima; M Isobe;

P413EFFECTS OF RECOMBINANT PLATELET FACTOR ACETYLHYDROLASE (rPAF-AH) ON LUNG INJURY IN PROLONGED HEART FAILUREM F Doursout; Y Liang; B Chelly; W Welch;

P4145-HT4-MEDIATED POSITIVE INOTROPIC EFFECT IS REGULATEDBY PHOSPHODIESTERASE 3 IN FAILING RAT HEART AND HUMAN VENTRICLE E Qvigstad; F Afzal; K W Andressen; M Aronsen; I Sjaastad; F Levy; T Skomedal; J Osnes; H K Mork; L R Moltzau;

P415CLENBUTEROL PREVENTS Gαi PROTEIN REDUCTION INDUCED BYMECHANICAL UNLOADING IN FAILING CARDIOMYOCYTES G K R Soppa; N Latif; J Lee; M A Stagg; U Siedlecka; M H Yacoub; C M N Terracciano;

P416CYTOKINE EXPRESSION PROFILING OF THE MYOCARDIUM REVEALS A ROLE FOR CX3CL1 IN HEART FAILUREC Husberg; S Nygård; A V Finsen; A Frigessi; L Gullestad; P Aukrust; A Yndestad; G Christensen; E Øie; J K Damas;

P417A NOVEL Z-GROOVE INDEX CHARACTERIZING MYOCARDIAL SURFACE STRUCTURE AND ITS MODIFICATION IN FAILING HUMAN HEART J Gorelik; L Yang; Y Zhang; M Lab; Y E Korchev; F Del Monte; S E Harding;

Moderators: D Das (Wyandotte, USA)I Fleming (Frankfurt, DE)

P418NADPH OXIDASE IS RELATED WITHLIPID PEROXIDATION AND REDOX-

SENSITIVE KINASE ACTIVATION IN HUMAN FAILING HEARTSC Nediani; E Borchi; G D'Amati; A Mugelli; E Cerbai;

P419MEASUREMENT OF TROPONIN PHOSPHATASE ACTIVITIES IN NON-FAILING AND FAILING HUMAN HEART MUSCLEA Messer; A Jacques; S Marston;

P420MICRORNAs IN THE HUMAN HEART:A CLUE TO FETAL GENE REPROGRAMMING IN HEART FAILURE T Thum; P Galuppo; S Kneitz; J Fiedler; L Van Laake; C Mummery; G Ertl; J Bauersachs;

P421TRANSIENT ENHANCEMENT OF OXIDANT STRESS AND COLLAGEN TURNOVER IN PATIENTS WITH ACUTE DECOMPENSATED CONGESTIVE HEART FAILUREY Kijima; M Kunishige; T Sakai; O Akutagawa; A Matsuo; A Nishibe; Y Nakagawa; T Hata;

P422REMODELING OF CARDIAC VENOUSSYSTEM IN HEART FAILUREA Sorgente; C Conca; A Auricchio; F F Faletra; E Pasotti; G Pedrazzini; T Moccetti;

P423SKELETAL MUSCLE MYOFIBRILLAR PROTEIN OXIDATION IN PATIENTS WITH HEART FAILUREL Dalla Libera; B Ravara; G Vescovo;

90P424SKELETAL MUSCLE PROTEIN

OXIDATION IN HEART FAILURE: THE EFFECT OF CARVEDILOLL Dalla Libera; B Ravara; D Danieli; A Angelini; G Vescovo;

P425PROGNOSTIC SIGNIFICANCE OF NT- PROBNP AND INFERIOR VENA CAVA DIAMETER IN PATIENTS WITH SEVERE ACUTE HEART FAILURER Pudil; M Tichy; V Blaha; J Vojacek;

P426LOW-INTENSITY EXERCISE TRAINING DELAYS ONSET OF HEART FAILURE AND IMPROVES SURVIVAL IN FEMALE SHHF RATSA J Chicco; S A McCune; M L Rees; G C Sparagna; K D Marshall; R L Moore;

P427ROUTINE LABORATORY VARIABLES MAY BE USED TO PREDICT IMMINENT HOSPITALIZATION IN CONGESTIVE HEART FAILURE (CHF) PATIENTS M S Munir; D Lai; A H Ahmed; I V Stupin; A M Brewer; K J Shankar; S W Casscells; R M Delgado;

P428CORRELATION OF TEMPERATURE WITH COMMON PROGNOSTIC MARKERS OF HEART FAILURE (HF) M S Munir; A H Ahmed; K J Shankar; I V Stupin; A M Brewer; G Poulin; S W Casscells; R M Delgado;

Moderators: I Anand (Minneapolis, USA)A Fucili (Ferrara, IT)

P429 ATRIAL FIBRILLATION (AF) AND HEART FAILURE (HF): EFFECT ON EXERCISE TOLERANCE

M F Piepoli; A Capucci;

P430CARDIOPULMONARY EXERCISE TESTING (CPET) IN THE IDENTIFICATION OF CANDIDATE FOR CARDIAC RESYNCHRONISATION THERAPY (CRT)M F Piepoli; A Capucci;

P431ASYNCHRONOUS RIGHT VENTRICULAR DDD STIMULATION IN COMPARISON TO VVI STIMULATION IN A PIG MODELS Voss; H Moellmann; H Nef; M Lintz; C Oltenau; C Troidl; A Elsaesser;

P432 INTERVENTRICULAR DYSSYNCHRONY DOES NOT IDENTIFY CRT RESPONDERS IN PATIENTS WITH HEART FAILURES Gaitani; P Artale; F Cecaro; T Toselli; G Guardigli; R Revel Chion; C Ceconi; D Mele;

P433MYOCARDIAL DEFORMATION DYSSYNCHRONY IS BETTER THAN VELOCITY DYSSYNCHRONY TO IDENTIFY RESPONDERS TO CRTP Artale; F Cecaro; T Toselli; C Pratola; P Notarstefano; R Revel Chion; C Ceconi; D Mele;

P434MECHANICAL VS ELECTRICAL DYSSYNCHRONY FOR CRT SELECTION IN PATIENTS WITH HFF Cecaro; P Artale; S Gaitani; C Pratola; R Revel Chion; T Toselli; D Mele; C Ceconi;

P435EFFECTS OF CARDIAC RESYNCHRONIZATION THERAPY ON THE MITOCHONDRIAL SUB-PROTEOME IN A CANINE

MODEL OF HEART FAILUREG Agnetti; S Elliot; L A Kane; C Yung; K Chakir; D Samantapudi; C Guarnieri;C M Caldarera; D Cass; J E Van Eyk;

P436EARLY PREDICTORS OF VENTRICULAR REMODELING AFTER MYOCARDIAL INFARCTIONF Mastrorilli; C Ceconi; E Antenucci; G Parrinello; R Ferrari;

P437THE BEAUTIFUL STUDY: BASELINE CHARACTERISTICS OF INCLUDED PATIENTS R Ferrari; K Fox; M Tendera; I Ford; P G Steg;

P438PROGNOSTIC VALUE OF PREDISCHARGE ECHO-DOPPLER INELDERLY AFTER ACUTE MYOCARDIAL INFARCTION: THE PREAMI ECHO STUDYS Golcea; G Nicolosi; C Ceconi; G La Canna; G Parrinello; M Chiariello; L Tavazzi; R Ferrari;

P439EFFECTS OF PERINDOPRIL ON LATE CARDIAC REMODELING IN ELDERLY PATIENTS AFTER ACUTE MYOCARDIAL INFARCTION: THE PREAMI ECHO STUDYS Golcea; G Nicolosi; C Ceconi; G La Canna; A Decarli; W J Remme; L Tavazzi; R Ferrari;

P440PREDISCHARGE ECHO-DOPPLER PREDICTORS OF LATE CARDIAC REMODELING IN THE PLACEBO ARM OF THE PREAMI ECHO STUDYS Golcea; G Nicolosi; C Ceconi; G Parrinello; M Chiariello; W J Remme; L Tavazzi; R Ferrari;

Poster mounting

Monday June 25, 2007


12.30-14.00

8 . 00 -9 .00

11.00-12.30

Frontier symposiumCalcium dysregula-tion and therapeutic

manipulation in heart failure

Frontier symposiumMetabolic aspects of CAD and CHF

Frontier symposiumProstanoid pathways in

atherosclerosis

Frontier symposiumRemodeling, theheart returns to

childhood

Frontier symposiumPharmacogenetics:

impact of adrenoceptor

polymorphisms

17.00-18.30Frontier symposiumStatins and cardiova-scular disease: oddi-ties and unexpected

findings

Frontier symposiumFrom ischemia tolethal arrhythmia

Frontier symposiumHow to optimizecardiac energymetabolism?

Frontier symposiumNew paradigms in G

protein-coupled receptor signaling

Frontier symposiumInjury and

protection duringmyocardial ischemia

and reperfusion


Janice Pfeffer Distinguished Lecture: Joanne Ingwall (USA): "Energetics of the failing heart: new tools yield new insights"14.00-14.45

President's Distinguished Lecture: Jeffrey Robbins (USA): "Genetic manipulation of the mammalian heart: what have we learned?"15.45-16.30

ISHR General Assembly14.45-15.45

Frontier symposiumNew insights into plaque vulnerabi-

lity


HALL EUROPA Nobel Laureate Lecture: Aaron Ciechanover (IL): "The ubiquitin proteolytic system: from basic mechanisms and onto human diseases and drug targeting"

Cultural Lecture: Massimo Montanari (IT): "The culture of food, between identity and exchange"

Followed by the "white" closing night

19.15-19.45

Frontier symposiumProtein kinases as

potential therapeutic targets

Frontier symposiumTranslating the regenerative

potential: focus onheart failure

Frontier symposiumCritical limb

ischemia: from clinical aspects to

therapeutic options


Lunch symposium Role of late (persistent) sodium current in cardiac pathophysiology and Moderated posters with lunch

Plenary session The complexity of heart failure9.00-10.30

Frontier symposiumSignposts on the multiple roads of

ageing

Frontier symposiumPotential conflictingdata relating the use

of statins in CHF

18.30-19.15

92

Hall Europa Monday June 25, 2007 – 09.00-10.30 Hall Europa

Plenary Session

Organized with an unrestricted educational grant from AstraZeneca

THE COMPLEXITY OF HEART FAILURE

ChairingL Erhardt (Malmö, SE), D Brutsaert (Antwerp, BE)

09.00 Is there still space for novel antineurohumoral approaches? 185I Anand (Minneapolis, USA)

09.20 The cell repair approach 186H Drexler (Hannover, DE)

09.40 The metabolic antinflammatory approach 187 P Poole-Wilson (London, UK)

10.00 The statins-based approach 188A P Maggioni (Florence, IT)

Coffee Break

93

Monday June 25, 2007 – 11.00-12.30

Frontier Symposia

Organized with an unrestricted educationalgrant from AstraZeneca

POTENTIAL CONFLICTING DATA RELATING

THE USE OF STATINS IN CHFChairing

A Branzi (Bologna, IT), J G F Cleland (Hull, UK)

11.00 Low cholesterol and low body weight have a negative prognostic factor in CHF 189S D Anker (Berlin, DE)

11.20 Statins might have other theoretical drawbacks 190A P Maggioni (Florence, IT)

11.40 Critical analysis of the available findings 191L Tavazzi (Pavia, IT)

12.00 The pleiotropic effects of statins should overcome potential drawbacks 192C Rapezzi (Bologna, IT)


INJURY AND PROTECTION DURING MYOCARDIAL

ISCHEMIA AND REPERFUSION

Chairing D J Hearse (London, UK), B Ostadal (Prague, CZ)

11.00 Mitochondrial Ion channels and ischemia-reperfusion injury 193B O’Rourke (Baltimore, USA)

11.20 Mitochondrial permeability transition and myocardial cell death 194J D Molkentin (Cincinnati, USA)

11.40 Reperfusion injury in 2007: a revival 195D Yellon (London, UK)

12.00 Post conditioning M Ovize (Lyon, FR) 196


94

Monday June 25, 2007 – 11.00-12.30

Frontier Symposia


SIGNPOSTS ON THE MULTIPLE ROADS OF AGEING

Chairing P Bernardi (Padua, IT), E G Lakatta (Baltimore, USA)

11.00 Cardiac genomics as a tool to probe heart senescence and its functional consequences 197T A Prolla (Madison, USA)

11.20 Vascular endothelial function and the impact of senescence 198R P Brandes (Frankfurt, DE)

11.40 Cardiac mitochondria between survival, senescence and sepulchre 199S J Sollott (Baltimore, USA)

12.00 The Omega of life and death: membrane fatty acids governing cardiac rhythm, contraction and metabolism 200 S Pepe (Melbourne, AUS)


G PROTEIN-COUPLED RECEPTOR SIGNALING

Chairing S Engelhardt (Würzburg, DE), S Harding (London, UK)

11.00 New insights into beta-adrenergic signaling 201S Engelhardt (Würzburg, DE)

11.20 Promiscuous G protein couplingof the ß2AR 202 S Harding (London, UK)

11.40 New pathways in GPCR-induced activation of RhoGTPases 203T Wieland (Heidelberg, DE)

12.00 Homo- and hetero-dimerization of heart GPCRs: potential physiological and therapeutic implications 204M Bouvier (Montreal, CA)


95

Monday June 25, 2007 – 11.00-12.30

Frontier Symposia


HOW TO OPTIMIZE CARDIAC ENERGY METABOLISM?

Chairing G D Lopaschuk (Edmonton, CA), M Marzilli (Siena, IT)

11.00 Inhibition of mitochondrial permeability prevents the transition to ischaemia 205 M Ovize (Lyon, FR)

11.20 Cardiomyocyte fatty acid oxidation: a new target in ischaemia and atherosclerosis? 206A Grynberg (Paris, FR)

11.40 Exercise and ischaemic cardiomyopathy: how to optimise energy metabolism 207 R Belardinelli (Ancona, IT)

12.00 Metabolic approach to cardiac protection 208W C Stanley (Cleveland, USA)


PROTEIN KINASES AS POTENTIAL THERAPEUTIC TARGETS

Chairing C M Caldarera (Bologna, IT), S Pepe (Melbourne, AUS)

11.00 CaMKII- B and CaMKII- C exhibit opposing effects on cardiomyocyte viability 209 R Xiao (Baltimore, USA)

11.20 AMP-activated protein kinaseM Kitakaze (Osaka, JP) 210

11.40 Protein kinase B/Akt 211 A Rosenzweig (Charlestown, USA)

12.00 GSK3β and cardioprotectionE Murphy (Bethesda, USA) 212


96

Monday June 25, 2007 – 11.00-12.30

Frontier Symposia


TRANSLATING THE REGENERATIVE POTENTIAL:FOCUS ON HEART FAILURE

Chairing O Alfieri (Milan, IT), R Bolli (Louisville, USA)

11.00 Myoblast transplantation for heart failure 213 P Menasché (Paris, FR)

11.20 Cardiac stem cell in heart failure 214 R Ferrari (Ferrara, IT)

11.40 Bone marrow cells for chronic ischemic cardiomyopathy 215B E Strauer (Düsseldorf, DE)

12.00 Bone marrow cells for severe heart failure 216J T Willerson (Houston, USA)

The Fondazione Villa Maria Cecilia Symposium

CRITICAL LIMB ISCHEMIA: FROM CLINICAL ASPECTS TO THERAPEUTICAL OPTIONS

Chairing G Biamino (Ravenna, IT), D Y Hu (Beijing, RC)

11.00 Physiopathology of critical limb ischemia 217L Dalla Paola (Abano Terme, IT)

11.20 Targeting endovascular solution for critical limb ischemia 218 S Braunlich (Leipzig, DE)

11.40 Surgical and endovascular approach:the future liaison 219A Stella (Bologna, IT)

12.00 Is there any role for cell-based approach to therapeutic angiogenesis? 220C Kalka (Bern, CH)


Supported by an unrestricted educational grant from CV Therapeutics

ROLE OF THE LATE (PERSISTENT) SODIUM CURRENT

IN CARDIAC PATHOPHYSIOLOGY

ChairingD Noble (Oxford, UK), A Zaza (Milan, IT)

12.30 Welcome and Introduction 221D Noble (Oxford, UK)

12.40 Role of late sodium channel in heart failure 222G Hasenfuss (Göttingen, DE)

12.55 Role of late sodium current in electrical instability associated with pathological conditions 223L Belardinelli (Palo Alto, USA)

13.10 Role of late sodium current on ventricular repola-rization of myocytes from hypertrophic hearts 224E Cerbai (Florence, IT)

13.25 Inhibition of the late sodium current to suppress Torsade de Pointes caused by potassium channel blockers 225M Vos (Utrecht, NL)

13.40 Inclusion of late sodium current in computermodels of cardiac cells 226D Noble (Oxford, UK)

13.55 Conclusions: the clinical utility of inhibition of the late sodium current 227A Zaza (Milan, IT)

Hall Rossa Monday June 25, 2007 – 12.30-14.00 Hall Rossa

Lunchtime Symposium

97

JANICE PFEFFER DISTINGUISHED LECTUREThis Award recognizes a distinguished investigator in the field of

cardiovascular remodeling, heart failure and/or hypertrophy.

Joanne Ingwall (Boston, USA) 228

“Energetics of the failing heart: new tools yield new insights”

Chair: M Hori (Osaka, JP)

ISHR GENERAL ASSEMBLY

Please, be there!

PRESIDENT’S DISTINGUISHED LECTUREThis Award recognizes a distinguished investigator in the field of

cardiovascular molecular biology, genetics, genomics or proteomics.

Jeffrey Robbins (Cincinnati, USA) 229

“Genetic manipulation of the mammalian heart: what have we learned?”

Chair: M Avkiran (London, UK)

coffee break

Hall Europa Monday June 25, 2007 – 14.00-16.30 Hall Europa

ISHR Award

98

14.00-14.45

14.45-15.45

15.45-16.30

99

Monday June 25, 2007 – 17.00-18.30

Frontier Symposia


FROM ISCHEMIA TO LETHAL ARRHYTHMIA

Chairing E Wettwer (Dresden, DE), A Zaza (Milan, IT)

17.00 Endogenous mediators and modulators of arrythmogenesis in ischemia 230M J Curtis (London, UK)

17.20 The substrate for ventricular fibrillation in acute ischemia 231A Kléber (Bern, CH)

17.40 Recruiting sympathetic nerves to the ischemic substrate 232P Chen (Los Angeles, USA)

18.00 Does genetic modulation of the autonomic nervous system contribute to the risk for sudden cardiac death? 233P J Schwartz (Pavia, IT)

Organized with an unrestricted educationalgrant from AstraZeneca

STATINS AND CVD: ODDITIES AND UNEXPECTED FINDINGS

Chairing G Grassi (Monza, IT), D E Newby (Edinburgh, UK)

17.00 Effects of statins in aortic stenosis 234D E Newby (Edinburgh, UK)

17.20 Effects of statins in atrial fibrillation 235G Lip (Birmingham, UK)

17.40 Effects of statinson renal function 236 G Remuzzi (Bergamo, IT)

18.00 Effects of statins in hypertension and diabetes 237G Grassi (Monza, IT)


100

Monday June 25, 2007 – 17.00-18.30

Frontier Symposia


NEW INSIGHTS INTO PLAQUE VULNERABILITY

Chairing P J De Feyter (Rotterdam, NL), B Magnani (Bologna, IT)

17.00 Detection of vulnerable plaques by IVUS and virtual histology 238G A Rodriguez Granillo (Buenos Aires, RA)

17.20 Palpography – a new tool or toy? 239J Schaar (Rotterdam, NL)

17.40 OCT as a connection between imaging and inflammation 240F Prati (Rome, IT)

18.00 New strategies for treatment of vulnerable plaques 241E McFadden (Cork, IE)


IMPACT OF ADRENOCEPTOR POLYMORPHISMS

Chairing T Eschenhagen (Hamburg, DE), M Tubaro (Rome, IT)

17.00 Functional importance of beta-adrenoceptor polymorphisms 242K Leineweber (Essen, DE)

17.20 Adrenergic receptor polymorphismsand chronic heart failure 243 J D Port (Denver, USA)

17.40 Beta-adrenoceptor polymorphisms and response to drugs 244J A Johnson (Gainesville, USA)

18.00 Functional importance of alpha-adrenoceptor polymorphisms 245C M Stein (Nashville, USA)


101

Monday June 25, 2007 – 17.00-18.30

Frontier Symposia

Organized with an unrestricted educationalgrant from I.F.B. STRODER

REMODELING, THE HEART RETURNS TO CHILDHOOD

Chairing G Nicolosi (Pordenone, IT), J Tamargo (Madrid, ES)

17.00 Remodeling: restoration of the cell life/death cycle 246 C Ceconi (Ferrara, IT)

17.20 Remodeling: restoration of the If channels 247A Mugelli (Florence, IT)

17.40 Remodeling in the elderly: does it exist and can it be prevented? 248W Remme (Rhoon, NL)

18.00 Can we realistically reverse remodeling? 249H Drexler (Hannover, DE)


PROSTANOID PATHWAYS IN ATHEROSCLEROSIS

Chairing F Bernardi (Ferrara, IT), J M Dogné (Namur, BE)

17.00 Natural history of atherosclerotic plaque 250C Basso (Padua, IT)

17.20 Oxidative stress, inflammation and atherothrombosis 251R De Caterina (Chieti, IT)

17.40 Prostanoid pathways in cardiovascular disease 252D Praticò (Philadelphia, USA)

18.00 Atherosclerosis, diabetes, oxidant stress: are prostanoid receptors the new targets? 253G Ambrosio (Perugia, IT)


102

Monday June 25, 2007 – 17.00-18.30

Frontier Symposia

Organized with an unrestricted educationalgrant from Sigma-Tau

METABOLIC ASPECTS OF CORONARY ARTERY

DISEASE AND HEART FAILURE

Chairing G Guardigli (Ferrara, IT), L Opie (Cape Town, ZA)

17.00 Alterations in energy metabolism in the ischaemic and failing heart 254G D Lopaschuk (Edmonton, CA)

17.20 Mitochondrial energy metabolism in heart failure: a question of balance 255 D P Kelly (St Louis, USA)

17.40 From fetal to fatal: metabolic adaptation and maladaptation in the failing heart 256H Taegtmeyer (Houston, USA)

18.00 Metabolic intervention as a therapeutic approach 257S Iliceto (Padua, IT)


CALCIUM DYSREGULATION AND

THERAPEUTIC MANIPULATION IN HEART FAILURE

Chairing I Anand (Minneapolis, USA), D Brutsaert (Antwerp, BE)

17.00 Calcium dysregulation in human heart failure 258G Hasenfuss (Göttingen, DE)

17.20 The ryanodine receptor in heart failure 259 S E Lehnart (New York, USA)

17.40 SERCA and phospholamban in heart failure 260E G Kranias (Cincinnati, USA)

18.00 Targeting calcium cycling for the treatment of heart failure 261R Hajjar (Charlestown, USA)


103

Monday June 25, 2007 – 18.30-19.45

Hall Europa

NOBEL LAUREATE LECTURE

Aaron Ciechanover (Haifa, IL)"The ubiquitin proteolytic system: from basic mechanisms

and onto human diseases and drug targeting" 262

Chair: M Rosen (New York, USA)

CULTURAL LECTURE

Massimo Montanari (Imola, IT)“The culture of food, between identity and exchange” 263

Chair: C Rapezzi (Bologna, IT)

18.30-19.15

19.15-19.45

104

CARDIOMYOPATHIES, MYOCARDITIS

Monday June 25, 2007 – 12.30-14.00


Moderators: E Arbustini (Pavia, IT)C Rapezzi (Bologna, IT)

P441REDUCED MYOCARDIAL CONTRACTILE FUNCTION IN DIABETIC CARDIOMYOPATHY—POSSIBLE ROLE OF MATRIX METALLOPROTEINASE-2B Turan; N Yaras; A Bilginoglu; R Schulz; A Koksoy;

P442 IN VITRO MOTILITY STUDIES OF A DCM MUTATION IN CARDIAC MUSCLE ACTIN.E Dyer; D Wells; C Redwood; S Marston;

P443 INCREASED SUSCEPTIBILITY TO HEART FAILURE IN HETEROZYGOUSCARRIER MICE OF CARNITINE TRANSPORTER GENE MUTATIONH Murakami; R Takahashi; T Murohara; K Okumura;

P444SEVERE ACTIVATION OF INFLAMMATORY PATHWAYS CONTRIBUTE TO DESMIN DEFICIENTCARDIOMYOPATHY AND HEART FAILURE

S Psarras; M Mavroidis; D Sanoudou; Y Capetanaki;

P445DESMIN DEFICIENT DILATED CARDIOMYOPATHY IS AMELIORATEDBY OVER-EXPRESSION OF ANTIOXIDANT ENZYMES MnSOD AND CATALASEK Rapti; Y Capetanaki;

P446TNF-a INDUCES DESMIN MODIFICATION, AGGREGATION AND LOSS OF INTERCALATED DISC LOCALIZATIONP Panagopoulou; D Mann; Y Capetanaki;

P447EFFECT OF ASTRAGALOSIDE ON CARDIAC MATRIX DEPOSITION IN MURINE CVB3 DILATED CARDIOMYOPATHYY Yang; R Chen; E Shen;

P448DYSTROPHIN DEFICIENT MDX MICE POORLY TOLERATE DOBUTAMINE STRESSG Van Der Mieren; G Buyse; J D'Hooge;P Herijgers;

P449 IMPROVED Ca2+ HANDLING AND REDUCED INFLAMMATION IN MDX

(DYSTROPHIC) MICE HEARTS FOLLOWING IN VIVO ANTIOXIDANT TREATMENTI A Williams; D G Allen;

P450ENHANCED MYOCARDIAL ERK ACTIVATION IN ANIMAL MODELS OFDUCHENNE AND LIMB GIRDLE 2F MUSCULAR DYSTROPHYS C Armstrong; M A Scott; K R Graber;

P451ERB2 RECEPTOR TYROSINE KINASE INTERACTS WITH THE DYSTROPHIN COMPLEX IN T-TUBULES OF A DILATED CARDIOMYOPATHY MODELS C Armstrong; M A Scott; K R Graber;

P452MUTATIONS IN TROPOMYOSIN THAT CAUSE DCM, AFFECT COOPERATIVITY OF CARDIAC MUSCLE THIN FILAMENTSS Marston; M Mirza; P Robinson; E Kremneva; D Levitsky; C Redwood; M El-Mezgueldi;

P453 INFLUENCE OF cTNI-R145G, RELATED TO HYPERTROPHIC CARDIOMYOPATHY, ON THE ISOTONIC CONTRACTION OF CARDIOMYOCYTES

105S Reis; C Littwitz; A Mügge; L Pott; K Jaquet;

Moderators: F Coccolo (Bologna, IT), S E Lehnart (New York, USA)

P454 SWIMMING INDUCES CARDIAC STRUCTURE CHANGE AND SUDDEN DEATH IN MICE CARRYING CARDIAC TROPONIN I MUTATIOND Yang; H Wu; J Ma; S Zhu; J Zhang;

P455ALTERATIONS OF THE UBIQUITIN-PROTEASOME SYSTEM IN CARDIOMYOPATHIC cMyBP-C MICEK R Sultan; S Schlossarek; D Englmann; N Vignier; T Eschenhagen; L Carrier;

P456ALTERED FUNCTION & POST-TRANSLATIONAL MODIFICATION OFCONTRACTILE PROTEINS IN MYECTOMY SAMPLES FROM HOCM PATIENTSC Gallon; A Jacques; A Messer; V Tsang;W McKenna; S Marston;

P457SEVERE CARDIAC PHENOTYPE IN ADOUBLE MUTANT MODEL OF FAMILIAL HYPERTROPHIC CARDIOMYOPATHY (FHC)T Tsoutsman; M Kelly; E Tu; L Lam; C E Seidman; J G Seidman; C Semsarian;

P458AZT-INDUCED CARDIOVASCULAR TOXICITY-ATTENUATED BY Mg-SUPPLEMENTATION I T Mak; J J Chmielinska; J H Kramer;W B Weglicki;

P459OLEUROPEIN RESTORES THE PATHOLOGICAL METABOLIC PATHWAYS INDUCED BY DOXORUBICIN’S CARDIOTOXICITY AN NMR BASED METABONOMIC STUDY I Andreadou; M Papaefthimiou; A Zira; M Constantinou; L Skaltsounis; E K Iliodromitis; D T Kremastinos; E Mikros

P460Cl-IB-MECA PROTECTS AGAINST DOXORUBICIN INDUCED CARDIOTOXICITY IN RATS

E Hochhauser; A Korkus; A Shainberg; Y Chepurko; B Vidne; E Porat; A Sagie;

P461EFFECTS OF STZ-INDUCED DIABETES ON CONTRACTION AND Ca2+ TRANSIENT IN RAT LEFT VENTRICULAR TRABECULAEL Zhang; A R J Phillips; M B Cannel; G J S Cooper; M L Ward;

P462 INHIBITION OF MATRIX METALLOPROTEINASES REDUCES STREPTOZOTOCIN-INDUCED DIABETIC CARDIOMYOPATHYR Schulz; M Sariahmetoglu; A Koksoy; A Bilginoglu; A Besikci; B Turan;

P463CARDIOPROTECTIVE EFFECT OF LOW-DOSE K-ATP CHANNEL OPENER IN MYOCARDITIS S Hirasawa; S Niwano; S Sasaki; Y Wakisaka; H Niwano; T Izumi;

P464RADICAL SCAVENGERS PREVENT THEDEVELOPEMENT OF MYOCARDITIS AND CARDIAC REMODELING IN RAT EXPERIMENTAL MODELS Niwano; S Sasaki; H Niwano; H Fukaya; T Izumi;

106

ENDOGENOUS CARDIOPROTECTION

Moderators: D Cokkinos (Athens, GR)D J Hearse (London, UK)

P465PRECONDITIONING AND POSTCONDITIONING: THE ESSENTIAL ROLE OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORES Y Lim; S M Davidson; D J Hausenloy;D M Yellon;

P466PROTECTIVE EFFECTS OF ISCHEMICPRECONDITIONING ARE ATTENUATED IN AGED RAT VENTRICULAR MYOCYTESJ D O’Brien; S E Howlett;

P467PRECONDITIONING INCREASES S-NITROSYLATION OF THE L-TYPE Ca2+ CHANNEL AND SERCA2aJ Sun; C Steenbergen; E Murphy;

P468APPLICATION OF ISCHEMIC PRECONDITIONING DURING CORONARY INTERVENTION USING A DISTAL EMBOLIC PROTECTION DEVICEH Takano; E Yamamoto; M Yasutake; S Aoki; K Asai; Y Kusama; M Takayama;

P469CYCLOOXYGENASE-2 MEDIATES THE CARDIOPROTECTION OF HYDROGEN SULFIDE

PRECONDITIONING IN RAT CARDIAC MYOCYTESJ Bian; L Hu; P K Moore;

P470ROLES OF p38MAPK AND PKC IN CONNEXIN43-MEDIATED GAP JUNCTION MODULATION BY ISCHEMIC PRECONDITIONINGT Miura; K Naitoh; T Yano; M Nishihara;K Ohori; T Satoh; K Shimamoto;

P471REPERFUSION SIGNALING IN PRECONDITIONED HEARTS: ROLE FOR PKC, THE MKATP CHANNEL, OXIDATIVE STRESS AND TRANSIENT ACIDOSISA M Wynne; D J Hausenloy;

P472HYPEROXIA CONFERS CARDIOPROTECTION IN RATS THROUGH INVOLVEMENT OF ROS AND MITOK-ATP CHANNELS OPENINGE A Tiravanti; G Colantuono; N Di Venosa; A Cazzato; D D'agostino; A Federici; T Fiore;

P473MOLECULAR EVIDENCE FOR THE ROLE OF GAP JUNCTIONS IN THE ANTIARRHYTHMIC EFFECT OF PRECONDITIONINGM Gönczi; R Papp; M Kovács; G Seprényi; Á Végh;

P474ALTERATIONS TO MITOCHONDRIALPROTEINS INITIATED DURING MYOCARDIAL ISCHEMIC PRECONDITIONING

M Y White; D A Brown; S Sheng; B O'Rourke; J E Van Eyk;

Moderators: S Anker (Berlin, DE) E Iliodromitis (Athens, GR)

P475 IS THE ISOLATED HEART PRECONDITIONED?K O Stenslokken; M Kaljusto; M B Dahln; A Rutkovsy; J Vaage;

P476 ISCHEMIC PRECONDITIONING (IPC) IS ASSOCIATED WITH ALTEREDTEMPORAL AND SUBCELLULAR DISTRIBUTION OF HEXOKINASE ACTIVITYC J Zuurbier; E Gurel; C Demirci; O Eerbeek; M W Hollmann;

P477 ISCHEMIC PRECONDITIONING BLUNTS THE POST-ISCHEMIC RESPONSE OF THE HYPOTHYROID RAT HEART A Kokkinos; A Dimopoulos; N Tsinarakis; I Mourouzis; H Karageorgiou; C Pantos; D V Cokkinos;

P478PRE-, AND POST-CONDITIONING WITH SELECTIVE INHBITION OF NUCLEOSIDE TRANSPORT AND ADENOSINE DEAMINASEA S Abd-Elfattah; H Aly; S Hannan;

P479LOVASTATIN INTERFERES WITH THE INFARCT SIZE-LIMITING

107EFFECT OF ISCHEMIC PRECONDI-TIONING AND POSTCONDITIONINGF G Kocsis; J Pipis; Z Giricz; T Csont; P Ferdinandy;

P480PHARMACOLOGICAL PRE- AND POST-CONDITIONING: A ROLE FOR LEVOSIMENDAN IN THE ISOLATED GUINEA PIG HEARTE F Du Toit; A Genis; S Genade;L H Opie; P Pollesello; A Lochner;

P481INSULIN AND ISCHEMIC PRECONDITIONING INDUCE CARDIOPROTECTIVE GSK3B BLOCKADE VIA STAT3 SIGNALLING IN THE ISOLATED RAT HEARTB N Fuglesteg; T V Andreasen; O D Mjøs; K Ytrehus;

P482ADENOSINE PRECONDITIONING ATTENUATES ISCHEMIA AND REPERFUSION INJURY IN YOUNG ADULT BUT NOT AGED RAT CARDIOMYOCYTESJ H Ferguson; S E Howlett;

P483GLIMEPIRIDE REDUCES THE THRESHOLD FOR ISCHEMIC PRECONDITIONING IN THE DIABETIC HEART A Wynne; D J Hausenloy; M M Mocanu; D M Yellon;

P484CARDIOPROTECTION BY TEMPERATURE PRECONDITIONINGIS MEDIATED BY FREE RADICALS, PKC AND AMPK ACTIVATION I Khaliulin; M S Suleiman; S J Clarke; H Lin; J Parker; A P Halestrap;

Moderators: G Heusch (Essen, DE)B O’Rourke (Baltimore, USA)

P485NOVEL PHARMACOLOGICAL COMPOUNDS AS TRIGGERS OF ISCHEMIC PRECONDITIONING IN VIVOI Andreadou; T Fotopoulou; M Koufaki;A Tsotinis; A Zoga; V Gizas; E Iliodromitis; D T Kremastinos;

P486LIPID RAFT AND MAP KINASE INTERACTION PLAY A KEY ROLE IN ANGIOTENSIN-II PRECONDITIONING OF THE HEARTM Das; S Das; D K Das;

P487PKC ENHANCES ADENOSINE A2B

RECEPTOR SENSITIVITY IN PRECONDITIONED RABBIT HEARTSJ M Downey; A Kuno; L Cui; M V Cohen;

P488ROLE OF NITRIC OXIDE IN REGULATING THE ACTIVATION OF ALDOSE REDUCTASE IN THE ISCHEMIC HEARTA Bhatnagar; S Srivastava; X Tang; K Kaiserova;

P489THE ROLE OF ERK ACTIVATION IN BETA-ADRENERGIC PRECONDITIONING (BPC)R Salie; A Lochner; J A Moolman;

P490MODERATE PEROXYNITRITE RELEASE TRIGGERS EARLY PRECONDITIONINGC Csonka; K Kupai; T Csont;

P Ferdinandy;

P491REACTIVE OXYGEN SPECIES MEDIATE ROBUST CARDIOPROTEC-TION INDUCED BY INTERMITTENT HYPOXIA CONDITIONINGH F Downey; M Ryou; D C Flaherty; A G Williams; E B Manukhina; R T Mallet;

P492SECOND WINDOW OF PRECONDI-TIONING IN A TYPE II DIABETES MOUSE MODELG Van Der Mieren; A Van Den Bergh; W Flameng; P Herijgers;

P493REMIFENTANIL CONFERS DELAYEDCARDIOPROTECTION IN VIVOY Kwan; W T Chun; W T Ming; I G Michael;

P494TARGETED DISRUPTION OF COX-2 GENE ABROGATES THE LATE PHASE OF ISCHEMIC PRECONDITIONINGY Guo; Q Li; W Wu; W Tan; X Zhu; R Bolli;

Moderators: E A Aiello (La Plata, RA)D Hausenloy (London, UK)

P495 TRANSIENT UPPER ARM ISCHEMIA REDUCES MYOCARDIAL INJURY IN PATIENTS UNDERGOING CARDIAC BYPASS SURGERYD J Hausenloy; P K Mwamure; J Harris; R J MacAllister; D M Yellon;

108P496POSTCONDITIONING REQUIRES

INACTIVATION OF GLYCOGEN-SYNTHASE KINASE 3β UPSTREAM OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE IN MICEL Gomez; A Gharib; M Paillard; M Ovize;

P497 ISCHEMIC POSTCONDITIONING’S CARDIOPROTECTION IS LOST IN AGED AND STAT3-DEFICIENT MICEK Boengler; A Buechert; Y Heinen; D Hilfiker-Kleiner; G Heusch; R Schulz;

P498PROTECTION OF THE ISOLATED RAT HEART BY EXENDIN-4, A GLP-1RECEPTOR AGONISTD P Sonne; T Engstrøm; M Treiman;

P499POSTCONDITIONING AND UROCORTIN TREATMENT CONFERRED PROTECTION AGAINSTISCHAEMIC-REPERFUSION INJURYE Roth; B Cserepes; B Rácz; J Lantos; S Bertok; S Ferencz; M Kurthy; G Jancso;

P500VARDENAFIL LIMITS INFARCTION IN ISOLATED RAT HEARTS AT REPERFUSION VIA GUANYLYL CYCLASE IN A SMALL CONCENTRATION RANGET Krieg; O Maas; U Donat; T Rütz; S Felix;

P501ANGIOTENSIN II AND POSTCONDITIONING IN REPERFUSION OF ISOLATED RAT HEART

M B Aljabri; B N Fuglesteg; T V Andreasen; K Ytrehus;

P502POSTCONDITIONING IN RABBITS WITH HAEMODYNAMIC NITRATE TOLERANCEZ Szilvássy; B Peitl;

P503POSTCONDITIONING REDUCES MYOCARDIAL INFARCT SIZE AND OXIDATIVE STRESS VIA MITOCHONDRIAL KATP CHANNEL ACTIVATION DURING 24 HOURS OF REPERFUSIONZ Zhao; J Mykytenko; J G Reeves; H Kin; A Zatta; R Jiang; R Guyton; J Vinten-Johansen;

P504 ISCHAEMIC POSTCONDITIONING REQUIRES TNF ACTIVATION TO CONFER PROTECTIONL Lacerda; L H Opie; S Lecour;

Moderators: D Brutsaert (Antwerp, BE)S J Sollott (Baltimore, USA)

P505POSTCONDITIONING REDUCES INFARCT SIZE AFTER ISCHEMIA/REPERFUSION IN PIGS A Skyschally; P Gres; P Van Caster; R Schulz; G Heusch;

P506THE METABOLIC SYNDROME RAISES THE THRESHOLD FOR CARDIOPROTECTIOND J Hausenloy; A Wynne; M M Mocanu;D M Yellon;

P507 INSULIN INDUCED CYTOPROTECTIONBY MIMICKING POSTCONDITIONING AT MYOCARDIAL REPERFUSIONE Helgeland; S Guvåg; A K Jonassen;

P508THE CARDIOPROTECTIVE EFFECT OF POSTCONDITIONING IS LOST INHYPERLIPIDEMIA: THE ROLE OF PEROXYNITRITEK Kupai; C Csonka; G Szucs; T Csont; P Ferdinandy;

P509POSTCONDITIONING PROTECTS BY MAINTAINING ACIDOSIS DURING REOXYGENATIONJ M Downey; M V Cohen; X Yang;

P510CRITICAL ROLE OF AGE, STRAIN ANDNUMBER OF CYCLES IN ISCHEMIC POSTCONDITIONINGS Somers; L Lacerda; N Suleman; L H Opie; S Lecour;

P511 INDUCIBLE NITRIC OXIDE SYNTHASE (iNOS), NOT NEURONAL NOS (nNOS) IN CARDIOPROTECTION BY FIBROBLAST GROWTH FACTOR-2 (FGF2)G Carpenter; D Porter; S Liao; G Newman; J Schultz;

P512 INTRINSIC AND EXTRINSIC P2 PURINOCEPTOR-MEDIATED CARDIOPROTECTION IN MICEJ P Headrick; S Wee; J N Peart;

P513REDOX ACTIVATION OF REF-1 POTENTIATES CELL SURVIVAL FOLLOWING MYOCARDIAL

109ISCHEMIA REPERFUSION INJURYN Gurusamy; G Malik; N V Gorbunov; D K Das;

P514SIGNALLING MECHANISMS AND PHOSPHOLIPASE A2

TRANSLOCATION IN TNF-α; MEDIATED CYTOPROTECTION IN

ISCHAEMIAB Loos; A Engelbrecht; R M Smith;

P515SULFORAPHANE IN THE PROTECTION OF CARDIOMYOCYTESFROM OXIDATIVE STRESSM Malaguti; C Angeloni; E Leoncini; E Pagnotta; P Biagi; S Hrelia;

P516SUBCELLULAR REDISTRIBUTION OF PROTEIN KINASE C IN CHRONICALLY HYPOXIC RAT HEARTM Hlavackova; J Neckar; O Novakova; F Kolar; R Musters; F Novak;

ISCHEMIA AND REPERFUSION

Moderators: M Canton (Padua, IT)S Harding (London, UK)

P517CARDIOVASCULAR ALTERATIONS INDUCED BY CHRONIC INTERMIT-TENT HYPOXIA IN SPONTANEOUSLY HYPERTENSIVE RATSD Godin-Ribuot; E Belaïdi; C Ribuot;

P518ASTRAGALOSIDES (IV) PROTECTEDHYPOXIA-REOXYGENATED CARDIOMYOCYTES BY IMPROVING CALCIUM HANDLINGX Chen; X Xu; Z Bian; D Yang; J Zhang;

P519EFFECT OF N-ACETYLCYSTEINE ONEXPRESSION AND ACTIVITY OF MnSOD IN CHRONICALLY HYPOXIC AND NORMOXIC RAT HEARTSP Balkova; O Novakova; F Novak; J Neckar; M Milerova; F Kolar;

P520ERYTHROPOIETIN REDUCES CASPASE 3 ACTIVATION IN THE

HUMAN ATRIAL MUSCLE UNDERGOING HYPOXIA/REOXYGENATION INJURYM M Mocanu; N R Mudalagiri; D M Yellon;

P521GLUCOSE IS A PREREQUISITE FOR INSULIN TO PROTECT THE ISCHEMICHEART VIA A WORTMANNIN-INSENSITIVE PATHWAYJ Lopes; A Lochner; B Huisamen;

P522CARDIAC METABOLIC AND FUNCTIONAL CHANGES CAUSED BYCORONARY DISEASEM S Suleiman; A Chase; C L Jackson; G D Angelini;

P523CALORIC RESTRICTION RESTORES ISCHEMIC TOLERANCE IN AGED HEARTS: EFFECTS ON PRO-SURVIVAL KINASESJ N Peart; P Johnson; J P Headrick;

P524EFFECTS OF ROSMARINIC ACID ON

MYOCARDIAL CALCIUM TRANSPORT AND CARDIAC FUNCTION IN ISCHEMIC RATSJ Yang; J Zhang;

P525CARDIOPROTECTIVE ACTIONS OF NECROSTATINS M Davidson; S Y Lim; J Hothersall; J C Simpkin; C C T Smith; D M Yellon;

P526TIME-RESPONSE OF CARDIOPRO-TECTIVE EFFECT OF DANCHENSUX Yu; F Fu; H Fan; C Yu; M Zhu; F Sun;

Moderators: M J Curtis (London, UK)L Opie (Cape Town, ZA)

P527OPIOID-INDUCED PROTECTION OF CARDIAC MYOCYTES FROM ISCHEMIC INJURY: INVOLVEMENT OF MICROTUBULES L Devillard; D Vandroux; C Tissier; J C Bopassa; R Ferrera; L Rochette; P Athias;

110P528ANTI-ISCHEMIC EFFECT OF IVA IN

ISOLATED RABBIT HEARTS: MODULATION OF CARDIAC METABOLISMC Ceconi; A Cargnoni; P Martina; R Ardesi; G Gitti; M Bouly; R Ferrari; S Maugeri;

P529THE TRANSCRIPTION FACTOR EGR-1 ISIMPLICATED IN MYOCARDIAL ISCHAEMIC REPERFUSION INJURY IN AN in vivo MODEL OF DIABETESV L Benson; A C McMahon; L M Khachigian; H C Lowe;

P530MALONYL CoA DECARBOXYLASE DEFICIENT MICE DISPLAY MINIMALINFARCT DURING in vivoISCHEMIA/REPERFUSIONW Wang; J E R Ussher; S Wang; J R B Dyck; G D Lopaschuk;

P531NO/cGMP PATHWAY IN ADRENOME-DULLIN MEDIATED CARDIOPRO-TECTION IN MOUSES A Hamid; M Totzeck; C Drexhage;I Thompson; R C Fowkes; G F Baxter;

T Rassaf;

P532 IS CARDIAC TOLERANCE TO ACUTE ISCHEMIA IN SPONTANEOUSLY HYPERTENSIVE RATS AGE- AND SEX-DEPENDENT?O Szarszoi; J Besik; Z Chvojkova; J Kunes; I Ostadalova; F Kolar; J Pirk; B Ostadal;

P533BMP2-SMADS SIGNAL PROTECTS CARDIOMYOCYTES FROM ISCHEMIA-REPERFUSION INJURY THROUGH THE INDUCTION OFβ-CATENINM Masaki; M Izumi; Y Fujio; M Hori; K Yamauchi-Takihara;

P534PARADOXICAL RESISTANCE TO ISCHAEMIC INJURY IN HEARTS OF NHE1-TRANSGENIC MICE A Cook; S Engelhardt; M Avkiran;

P535P38 MAPK IS INVOLVED IN ADENOSINERECEPTORS’ PROTECTION AGAINST ISCHEMIA-REPERFUSION (I/R) INJURY OF THE HEARTE Hochhauser; A Shainberg; Y Chepurko; B Vidne; E Porat; D Leshem;

P536SELECTIVE INACTIVATION OF THE CARDIAC PROTEASOMES OCCURS DURING ISCHEMIA/REPERFUSION INJURYA V Gomes; D Liem; C Zong; Q Qin; G Young; P Ping;

Moderators: G Ambrosio (Perugia, IT)M Ovize (Lyon, FR)

P537CARDIOPROTECTIVE ACTIONS OF UPREGULATED L-ARGININE (L-ARG) TRANSPORTK Venardos; L Willems; D M Kaye;

P538EFFECTS OF ISCHEMIA AND REPERFUSION ON CONTRACTION, INTRACELLULAR Ca2+ AND CELL

VIABILITY IN MALE AND FEMALE MYOCYTESJ L Ross; S E Howlett;

P539H2S PRODUCTION IN MYOCARDIAL ISCHAEMIA AND REPERFUSIOND J Elsey; R C Fowkes; G F Baxter;

P540ROLE OF HIGH MOLECULAR WEIGHT ISOFORMS OF FIBROBLAST GROWTH FACTOR-2 (FGF-2) IN CARDIAC ISCHEMIA-REPERFUSION INJURY (I/R)S Liao; G Newman; T Doetschman; J E J Schultz;

P541GLUTATHIONE-S-TRANSFERASE-P DEFICIENCY IN MICE ENHANCES MYOCARDIAL SENSITIVITY TO ISCHEMIA-REPERFUSIONA Bhatnagar; B Hill; Y Guo; R Prough;S Prabhu; R Bolli; D Conklin;

P542PROINFLAMMATORY CYTOKINES LINK TLR4 SIGNALING TO POST-ISCHEMIC CARDIAC DYSFUNCTIONL Ao; J Cha; N Zou; D A Fullerton; X Meng;

P543THE MECHANISM OF AUGMENTED CYTOKINE RESPONSE TO ISCHEMIA IN THE AGING HEARTL Ao; N Zou; X Yang; X Su; D A Fullerton; J C Cleveland; X Meng;

P544ENHANCED TOLERANCE OF RAT MYOCARDIUM TO ISCHEMIA AND REPERFUSION INJURY EARLY AFTER ACUTE MYOCARDIAL INFARCTION

111I Mourouzis; A Dimopoulos; C Xinaris; K Markakis; M Panagiotou; C Pantos; D V Cokkinos;

P545CARDIAC SPECIFIC OVEREXPRESSIONOF COX-2 PROTECTS AGAINST ISCHEMIA/REPERFUSION INJURYJ Inserte; B Molla; V Hernando; P Martin-Sanz; L Boscà; M Casado; D Garcia-Dorado;

P546ACUTE MYOCARDIAL INFARCTION IS A GLOBAL CORONARY PHENOMENONR M Chreih; D Deleanu; I Modavu; C Ginghina;

Moderators: D P Kelly (St Louis, USA)W Remme (Rhoon, NL)

P547 ISOPROSTANE RELEASE FOLLOWINGCORONARY REVASCULARIZATION IN HUMANSK Berg; H Brurok; S Skarra; R Haaverstad; R Wiseth; S Basu; P Jynge;

P548NOVEL CARDIOPROTECTIVE ROLE OFCONNECTIVE TISSUE GROWTH FACTOR (CTGF) IN ISCHEMIA / REPERFUSIONJ Gravning; M Ahmed; V Martinov; T Lueder; G Czibic; T Edvardsen; G Valen; H Attramadal;

P549ATTENUATION OF ISCHEMIA REPERFUSION INJURY IN FAILING

HEARTS BY ENDOTHELIN-A RECEPTOR BLOCKADEK Trescher; M Bauer; W Dietl; S Hallstroem; E Wolner; B Podesser;

P550DIFFERENTIAL CARDIOPROTECTIVE EFFECTS OF CARDIAC AND NON-CARDIAC ADENOSINE DURING GLOBALISCHEMIA AND REPERFUSION, in vivoA S Abd-Elfattah; M Ding; S J Mustafa; M A Mansour; F R Nomair;

P551SIMVASTATIN SUPPRESSES INFLAMMATION AND PRESERVES MYOCARDIAL FUNCTION AFTER CORONARY MICROEMBOLISATION IN RABBITSH Post; A Schmidt; J Schmitto; G Schultz; R Waldmann-Beushausen; H Dörge; B Pieske;

P552ENHANCED TOLERANCE TO ISCHEMIA IN THE DIABETIC RAT HEARTS IS ABROGATED BY HYPERCHOLESTEROLEMIA: THE ROLE OF PPART Ravingerova; A Adameova; E Antonopoulou; A Lazou; M Kuzelova; P Svec;

P553CHANGES IN PPAR ISOFORMS EXPRESSION AND PROTECTION BY SIMVASTATIN IN THE DIABETIC-HYPERCHOLESTEROLEMIC RAT HEARTA Adameová; T Ravingerova; E Antonopoulou; A Lazou; M Kuzelova; P Svec;

P554ADIPONECTIN ATTENUATES NITRATIVE STRESS IN ISCHEMIC/ REPERFUSED CARDIOMYOCYTESX L Ma; L Tao; X Y Jiao; T Christopher; B L Lopez; B Goldstein; Y X Yuan;

P555APELIN REDUCES MYOCARDIAL REPERFUSION INJURY INDEPENDENTOF PI3K/AKT AND P70S6KM J Kleinz; G F Baxter;

P556 INHIBITION OF NADPH OXIDASE DURING ISCHEMIA-REPERFUSION PROTECTS RAT CARDIOMYOBLASTSFROM CELLULAR DEATHE Borchi; C Nediani; R Favilli; P Nassi;

Moderators: T J C Ruigrok (Utrecht, NL) D Yellon (London, UK)

P557 SIVELESTAT SODIUM PRESERVES CORONARY ENDOTHELIAL FUNCTION DURING ISCHEMIA AND REPERFUSIONM Kambe; R Bessho; M Fujii; M Ochi; K Shimizu;

P558MYOCARDIAL PROTECTION: THE EFFICACY OF SIVELESTAT SODIUM, ASAN INHIBITOR OF REPERFUSION INJURYM Kambe; R Bessho; M Fujii; M Ochi; K Shimizu;

P559 INSULIN PROTECTS THE ISOLATEDHEART FROM MI/R INJURY: A

112CROSS-TALK BETWEEN PI3K/AKT AND SAPKs/JNKsF Gao; H T Liu; H C Wang; W Y Guo;

P560ACUTE HYPERGLYCEMIA DURING ISCHEMIA EXACERBATES MI/R INJURY AND ABOLISHES CARDIOPROTECTIVE EFFECTS OF GIKF Gao; H Su; X Sun; H C Wang; G Jia;

P561 INSULIN REDUCES MYOCARDIAL ISCHEMIA-REPERFUSION INJURY VIA INHIBITION OF LEUKOCYTE-ENDOTHELIUM ADHERENCEF Gao; F S Wu; J Li; W C Liu; W Y Guo; H C Wang; H T Liu;

P562DIETARY ANTI-OXIDANT RICH OIL PROTECT AGAINST ISCHAEMIA/ REPERFUSION INJURY BY ACTIVA-TION OF PKB/AKT AND P38 MAPKJ Van Rooyen; J Esterhuyse; E F Du Toit; A Lochner; A M Engelbrecht;

P563HEART RATE REDUCTION INDUCED WITH IVABRADINE IN MIDDLE-AGED POST-INFARCTED RATS IMPROVES MYOCARDIAL PERFUSIONE I Dedkov; W Zheng; L P Christensen; R M Weiss; R J Tomanek;

P564CARDIOPROTECTIVE EFFECT OF POLY(ADP-RIBOSE) POLYMERASE INHIBITION: ROLE OF PI3K / AKT J C Kwan; L Gao; P S Macdonald; M Hicks;

P565N-3 POLYUNSATURATED FATTY ACIDS AND NITRIC OXIDE SYNTHASES ACTIVITYO Moybenko; A Shysh; T Kukoba; A Kotsjuruba; O Kharchenko;

P566AMPK ACTIVATION AT REPERFUSION:A NOVEL CARDIOPROTECTIVE TARGET?M Paiva; L Gonçalves; L Providência; M M Mocanu; D M Yellon;

P567PTEN HAPLOINSUFFICIENCY IS NOT ABLE TO PROTECT THE MYOCARDIUM AGAINST ISCHAEMIA REPERFUSION INJURYH K Siddall; M M Mocanu; D M Yellon;

Moderators: W C Stanley (Cleveland, USA)M G Vila Petroff (La Plata, RA)

P568LEPTIN-INDUCED CARDIOPROTEC-TION IS DEPENDENT ON THE PRESENCE OF FUNCTIONAL OB-RbRECEPTORSR A Dixon; C C T Smith; D M Yellon;

P569APELIN, THE POTENTIALLY THERAPEUTIC ADIPOCYTOKINE, PROTECTS AGAINST MYOCARDIAL ISCHEMIA-REPERFUSION INJURYC C T Smith; J C Simpkin; S Lim; S M Davidson; A Wynne; D M Yellon;

P570HEMOXYGENASE-1 ENZYME INVOLVESIN THE CARDIOPROTECTIVE

EFFECT OF THE ALPHA-MELANOCYTE-STIMULATING HORMONEM Vecsernyes; P Der; R Gesztelyi; D Karsai; A Tosaki; B Juhasz;

P571ADRENOCORTICOTROPE HORMONE FRAGMENT (4-10) DECREASES THE ISCHEMIA/REPERFUSION INDUCED INJURY IN ISOLATED RAT HEARTSB Juhasz; A Jakab; R Gesztelyi; G Szabo; A Tosaki; M Vecsernyes;

P572ACTIVATION OF PARTICULATE GUANYLATE CYCLASE DURING EARLY REPERFUSION LIMITS INFARCT SIZE IN THE RAT ISOLATED HEARTD S Burley; G F Baxter;

P573PROTECTIVE EFFECT OF SHEN-FU INJECTION ON HEART INJURY INDUCED BY ISCHEMIA/REPERFUSIONT Zhang; M Zhao;

P574MYOCARDIAL PROTECTION AND NEUTROPHIL ELASTASE INHIBITOR: ADDITIVE EFFECT OF THE SIVELESTAT ON REPERFUSION INJURYM Fujii; R Bessho; M Kambe; M Ochi; K Shimizu;

P575BENEFICIAL EFFECTS OF Q9 AND Q10 IN ISOLATED GUINEA PIG HEARTSG Szabo; I Lekli; S Das; D K Das; R Geszthelyi; A Tosaki;

P576CARDIOPROTECTIVE EFFECTS OF RESVERATROL IN ISOLATED

113ZUCKER OBESE RAT HEARTSA Tosaki; B Juhasz; I Bak; S Das; D K Das; E Varga; I Lekli;

Moderators: J D Molkentin (Cincinnati, USA)R Xiao (Baltimore, USA)

P577 OPIOID RECEPTOR ACTIVATION PREVENTS REPERFUSION INJURY BYTARGETING MITOCHONDRIAL PERMEABILITY TRANSITIONZ Xu; Y Jang; H Wang; J Xi; R A Mueller; E Norfleet;

P578THE CARDIOPROTECTIVE EFFECT OFNOC-18 ON ISCHEMIA/REPERFUSION INDUCED MITOCHONDRIAL DAMAGE AND CELL VIABILITYR Morkuniene; O Arandarcikaite; J Barauskaite; A Jekabsone; V Borutaite;

P579HSP70 IS DOWNREGULATED AT LATE STAGES AFTER MYOCARDIAL INFARCTION IN RATS; A RESPONSE REVERSED BY THYROID HORMONEI Mourouzis; C Xinaris; K Markakis; S Tzeis; I Paizis; P Moraitis; C Pantos; D V Cokkinos;

P580G PROTEIN-COUPLED RECEPTOR KINASES 2 (GRK2) AND ACUTE MYOCARDIAL INFARCTIONG Santulli; A Campanile; M Ciccarelli; L Spinelli; J Huber; S De Gennaro; B Trimarco; G Iaccarino;

P581TEMPORAL CHANGES IN MMP-9, TIMP-3 AND iNOS AFTER MYOCARDIAL

INFARCTION WITH OR WITHOUT REPERFUSION IN THE RATB I Jugdutt; A Palaniyappan; H Idikio; R R E Uwiera;

P582EXPRESSION OF PLATELET DERIVEDENDOTHELIAL CELL GROWTH FACTOR IN MYOCARDIAL INFARCTION IN RATST Hemalatha; B Murali Manohar; S Subramaniam; R Puvanakrishnan;

P583ENHANCED MMP-9 EXPRESSION BY CIRCULATING MONOCYTES AFTER ACUTE MYOCARDIAL INFARCTIONL Fang; X M Gao; A M Dart; X J Du;

P584THE CHANGE IN ALPHA-1 ANTITRYPSIN (A1AT) PLASMA LEVELS WITH TIME IN NEWLY DIAGNOSED ACUTE MYOCARDIAL INFARCTION (AMI) PATIENTS Z J El-Akawi; Y M Aljawarneh; Q Al-Shamayleh;

P585CARDIOPROTECTIVE EFFECT OF PHOSPHODIESTERASE INHIBITOR 'ORDONAFIL' COMPARED TO THAT OF SILDENAFILS Y Khatib; T R Tamimi;

P586ACTIVATION OF CYCLIC GMP/PKG PATHWAY FAILS TO LIMIT INFARCT SIZE IN HEARTS FROM HYPERLIPIDEMIC RATSZ Giricz; D S Burley; P Ferdinandy; G F Baxter;

Moderators: M Kitakaze (Osaka, JP)E G Lakatta (Baltimore, USA)

P587COENZYME Q10-LOADED LIPOSOMESEFFECTIVELY PROTECT THE MYOCARDIUM IN RABBITS WITH ANACUTE EXPERIMENTAL MYOCARDIALINFARCTIONT Levchenko; D D Verma; W Hartner; V Torchilin;

P588PROTECTIVE EFFECT OF OCOTILLOLON ACUTE MYOCARDIAL INJURY INDUCED BY LAD IN RATC Yu; F Fu; X Yu; M Zhu;

P589THE REDUCTION IN INFARCT SIZE PRODUCED BY CANNABINOIDS IN RATS IN VIVO IS MEDIATED BY CB2-RECEPTORSD Lamontagne; P Lepicier;

P590CEILING OF CARDIOPROTECTION WITH THE PHARMACOLOGICAL POSTCONDITIONING INDUCED BY THE PHYTOESTROGEN GENISTEINN Couvreur; R Tissier; X Waintraub; M Gervais-Taurel; S Pons; R Zini; A Berdeaux; B Ghaleh;

P591ADEQUATE PRE-ISCHEMIC MYOCARDIAL GLYCOGEN CONTENTIS CRITICAL FOR ISCHEMIC PRECONDITIONING EFFECTH Kim; J S Seo;

P592EFFECT OF HYDROXYSAFFLOR YELLOW A COMBINED WITH

114NITROGLYCERIN ON ACUTE MYOCARDIAL INFARCTIONT Wang; F Fu; B Han; X Yu; M Zhu; L Zhang;

P593CARDIOPROTECTIVE ACTIONS OF THE NOVEL ADIPOCYTOKINE VISFATIND J Hausenloy; S Lim; A J Paramanathan; S M Davidson; D M Yellon;

P594METFORMIN CARDIOPROTECTS

THE DIABETIC HEART BY INHIBITING mPTP OPENING VIA THE RISK PATHWAYD J Hausenloy; G S Bhamra; S M Davidson; R Carr; M M Mocanu; D M Yellon;

P595UTP PROTECTS CULTURED CARDIOMYOCYTES AND IMPROVES RAT HEART FUNCTION AFTER MYOCARDIAL INFARCTIONE Hochhauser; S Yitzhaki; A Shainberg; Y Chepurko; B Vidne; A Sagie; E Porat;

P596CARDIOPROTECTIVE EFFECTS OF TRO40303S Schaller; B Buisson; R Souktani; A D’Anglemont; M Michaud; C Drouot; A Berdeaux; R Pruss;

P597EVALUATION OF OXIDATIVE DNA DAMAGE AND ANTIOXIDANT DEFENCE AFTER REPERFUSION THERAPY IN ACUTE MYOCARDIAL INFARCTIONY Dincer; S Himmetoglu; E Bozcali; V A Vural; T Akcay;

VASCULAR BIOLOGY

Moderators: R De Caterina (Chieti, IT)S Pepe (Melbourne, AUS)

P598FUNCTIONAL INVOLVEMENT OF STIM1 IN VASCULAR SMOOTH MUSCLE CELL PROLIFERATIONY Takahashi; H Watanabe; T Ohba; H Ito;

P599ROLE OF MICROTUBULES IN THE METALLOPROTEINASE PROCESSING IN HUMAN VASCULAR SMOOTH MUSCLE CELLSD Vandroux; S Voisin; C Tissier; L Devillard; L Dumont; L Rochette; P Athias;

P600SERCA2a GENE TRANSFER REDUCESVASCULAR SMOOTH MUSCLE CELL PROLIFERATION IN HUMAN ARTERIES:

A NEW TARGET FOR RESTENOSIS?L Lipskaia; S Lehoux; B Esposito; P Le Prince; N Bonnet; C Le Feuvre; R Hajjar; A Lompré;

P601 INCREASED EXPRESSION OF β1

SUBUNITS ENHANCES THE ROLE OF BKCa IN NTG-INDUCED RELAXATION OF NITRATE TOLERANT ARTERIESS T O'Rourke; S Ghatta; M L Johnson; L P Reynolds;

P602THE P22PHOX GENE IS TRANSCRIP-TIONALY REGULATED BY NF-kB AND AP-1 IN HUMAN AORTIC SMOOTH MUSCLE CELLSA Manea; A V Gafencu; S A Manea; M Raicu; M Simionescu;

P603EFFECT OF ENDOTHELIAL-SPECIFIC

NOX2 OVEREXPRESSION ON ENDOTHELIAL FUNCTION AND BLOOD PRESSURES P Alom-Ruiz; C E Murdoch; R Ray; A Brewer; A M Shah;

P604OVEREXPRESSION OF THE LOX-1 RECEPTOR AFFECTS CONTRACTILEAND ELECTROPHYSIOLOGICAL FUNCTION IN SMALL ARTERIESB Eichhorn; G Müller; H Morawietz; U Ravens;

P605SiRNA TARGETING SHP-1 ACCELERATES ANGIOGENESIS IN HINDLIMB ISCHEMIAN Makino; M Sugano;

P606GRK5 REGULATES NFkB TRANSCRIPTION ACTIVITY IN ENDOTHELIAL CELLS

115D Sorriento; G Santulli; A Campanile; B Trimarco; G Iaccarino;

P607bFGF-INDUCED ANGIOGENESIS IN ISCHEMIC MYOCARDIUM IS ASSOCIATED WITH CALRETICULIN DOWNREGULATIONX Liu; X Wu; L Cai; S Sun; F Liu;

Moderators: C Basso (Padua, IT)J Tamargo (Madrid, ES)

P608STRATEGY FOR “RAISING HDL”; HDL-CHOLESTEROL OR HDL PARTICLE NUMBERS INSIGHT FROM CHOLESTERYL ESTER TRANSFER PROTEIN DEFICIENCYK Hirano; S Yamashita; M Hori;

P609NO AND EDHF IN ATHEROSCLEROSIS AND HEART FAILURES Chlopicki; G Csanyi; M Franczyk; L Drelicharz; J Jawien; M Gajda; L Wojnar; P Pisulewski; T Skorka;

P610ROLE OF THE PIM-1 KINASE FOR VASCULO-PROLIFERATIVE PROCESSES IN THE CONTEXT OF THE ATHEROSCLEROTIC PLAQUE MILIEUM Willert; R H Strasser; R C Braun-Dullaeus;

P611TRANSDUCTION OF STAR DECREASES LIPID ACCUMULATION AND ATHEROSCLEROTIC LESIONS IN APOLIPOPROTEIN e-DEFICIENT MICE

L Yin; Y Ning; L Xu; Y Jiang; C Xu; S Chen; C Lu; F Zhao;

P612THE MECHANISM OF MCMV INFECTION CONTRIBUTING TO ATHEROGENESIS IN ApoE KNOCKOUT MICER Chen; S Xiong; Y Yang;

P613THE SPHINGOSINE-1-PHOSPHATE ANALOGUE FTY720 REDUCES ATHEROSCLEROSIS IN APOLIPOPROTEIN E-DEFICIENT MICEP Keul; M Tölle; S Lucke; K Von Wnuck Lipinski; G Heusch; M Schuchardt; M Van Der Giet; B Levkau;

P614THE ACE-INHIBITOR PERINDOPRILATHAS HIGH SELECTIVITY FOR BRADYKININ BINDING SITES OF HUMAN SOMATIC ACEC Ceconi; G Francolini; A Olivares; D Bastianon; G Gitti; T Bachetti; R Ferrari;

P615DIFFERENTIAL ACTION OF ACE INHIBITORS ON THE eNOS PATHWAYL Comini; T Bachetti; C Ceconi; R Ferrari;

P616EFFECTS OF ACE INHIBITORS ON RATE OF ENDOTHELIAL APOPTOSIS:IN VIVO STUDIESG Francolini; D Bastianon; G Gitti; L Comini; C Ceconi; R Ferrari;

P617ROSUVASTATIN STIMULATES ENDOTHELIAL NITRIC OXIDE SYNTHASE AND INHIBITS APOPTOSISIN HUMAN ENDOTHELIAL CELLST Bachetti; L Agnoletti; G Francolini; D Bastianon; R Ferrari;

Moderators: L Comini (Gussago, IT)D Praticò (Philadelphia, USA)

P618 ROSUVASTATIN STIMULATES ENOsAND INHIBITS APOPTOSIS IN HUVECsEXPOSED TO SERA FROM CARDIOVA-SCULAR DISEASES PATIENTSL Agnoletti; T Bachetti; D Bastianon; G Francolini; R Ferrari;

P619ACE INHIBITION WITH PERINDOPRIL AND ENDOTHELIAL FUNCTION RESULTS OF A SUBSTUDY OF THE EUROPA STUDY: PERTINENTC Ceconi; K M Fox; W J Remme; M L Simoons; M Bertrand; G Parrinello; C Kluft; D V Cokkinos; R Ferrari;

P620A NOVEL PEPTIDE DERIVATIVE INHIBITING COMPLEMENT EXPRESSION IN ENDOTHELIAL CELLS IN ACUTE MYOCARDIAL INFARCTIONR Puvanakrishnan; M Sumitra; P Manikandan; B Murali Manohar;

P621ENDOTHELIAL INTERCELLULAR JUNCTION INTEGRITY IN AORTA OFHYPERTRIGLYCERIDEMIC RATS

116K Dlugosova; M Fialova; F Kristek; N Tribulova; L Okruhlicova;

P622THYMOSIN β4 IS ESSENTIAL FOR CORONARY VESSEL DEVELOPMENTAND PROMOTES NEOVASCULARISA-TION VIA ADULT EPICARDIUMN Smart; C A Risebro; A A D Melville; K Moses; R J Schwartz; K R Chien; P R Riley;

P623 IMPAIRMENT OF RIGHT CORONARY VOLTAGE-GATED K+ CURRENT IN RATWITH HYPOXIC PULMONARY HYPERTENSIONJ Hyvelin; M C Lemaire; V Eder; P Bonnet;

P624DOXYCYCLINE AMELIORATES DIABETES-INDUCED VASCULAR DYSFUNCTIONA Koksoy; E Zeydanli; E Tanriverdi; R Schulz; B Turan;

P625ALTERED CORONARY VASODILATORMECHANISMS IN FETAL SHEEP DURING MATERNAL NUTRIENT RESTRICTIONS O'Rourke; R Tunstall; S Ghatta; K Vonnahme; J Caton; L Reynolds;

P626BENEFICIAL EFFECT OF SODIUM SELENATE ON VASCULAR DYSFUNCTION IN DIABETIC RATSE N Zeydanli; E Tanriverdi; A Seymen; E Tuncay; H Gurdal; A Koksoy; B Turan;

P627ADIPONECTIN IMPROVES ENDOTHELIAL DYSFUNCTION IN HYPERLIPIDEMIC RATSX L Ma; R Li; H F Zhang; F Gao; T L Christopher; B L Lopez; L Tao;

Moderators: J M Dogné (Namur, BE)M Marzilli (Siena, IT)

P628FUNCTIONAL AND MORPHOLOGICAL CHANGES IN VESSELS OF HYPERTRIGLYCERIDEMIC RABBITS WITH NORMOCHOLESTEROLEMIAA Ishihata; Y Katano;

P629LOSARTAN AMELIORATES DIABETIC VASCULAR HYPER-REACTIVITY TO ANGIOTENSIN II BY REDUCING ROCK1EXPRESSION AND ACTIVITYTL Raimondi; S Franchi-Micheli; E Cerbai; A Mugelli; P Failli;

P630SYNTHETIC FLAVONOL PRESERVES POST-ISCHAEMIC ENDOTHELIAL FUNCTION AFTER 7 DAYS REPERFUSION IN CONSCIOUS SHEEPS Wang; C J Thomas; G J Dusting; O Woodman; C May;

P631ENDOTHELIUM-DEPENDENT PROTHROMBOTIC AND FIBRINOLYTIC FACTORS IN PATIENTS WITH CHRONICHEART FAILUREK A Khmelnitskaya; E V Shlyakhto; M U Sitnikova;

P632SIROLIMUS ACTIVATES KATP

CHANNELS TO CAUSE SMOOTH

MUSCLE RELAXATION IN HUMAN ARTERIESS T O'Rourke; R Tunstall; S Ghatta; S Kareem; M Rahman;

P633THE EFFECT OF CARVEDILOL ON ENDOTHELIAL HEMOSTASIS IN PATIENTS WITH CHRONIC HEART FAILUREK A Khmelnitskaya; E V Shlyakhto; M U Sitnikova;

P634RELEASE OF TNFα DURING SVG-STENTING AND ITS RELATION TO PLAQUE EXTRUSION AND RESTENOSISK Leineweber; D Böse; T Konorza; R Erbel; G Heusch;

P635APROTININ ATTENUATES THE INFLAMMATORY RESPONSE IN HUMAN CORONARY ENDOTHELIAL CELLS INDUCED BY DISTINCT MECHANISMSL Ao; Y Song; J Sykes; D Fullerton; X Su; X Meng;

P636ABNORMAL EXPRESSION OF STROMELYSIN-2 (MMP10) IN MARFAN SYNDROME (MFS) AND BICUSPID AORTIC VALVE (BAV) ANEURYSMH Do; M Nataatmadja; M West;

P637CHOLINE LYSOPHOSPHOLIPID RELEASE FROM HUMAN CORONARYARTERY ENDOTHELIAL CELLSJ McHowat;

117

PLATELETS, THROMBOSIS AND COAGULATION

Moderators: F Bernardi (Ferrara, IT)A Rosenzweig (Charlestown, USA)

P638TISSUE FACTOR AND COAGULATION FACTOR VII LEVELS DURING AMI: ASSOCIATION WITH GENOTYPE AND ADVERSE EVENTSS Luccarelli; A Frangione; G Campo;

P639USAGE AND UTILITY OF PFA-100 AND CONE NAD PLATELET ANALYZERIMPACT-R FOR TESTING PLATELET FUNCTION M Postula; A Serafin; M Marchel; K Filipiak; B Tarchalska; G Opolski;

P640FREQUENCY OF ASPIRIN RESISTANCEIN PATIENTS WITH STABLE CORONARY ARTERY DISEASE ON LONG-TERM ASPIRIN THERAPY M Postula; A Serafin; K Filipiak; B Tarchalska;

P641UTILITY OF PLATELET FUNCTION ANALYZER PFA-100 IN ASSESMENT OF PLATELET FUNCTION IN

PATIENTS WITH STABLE CORONARY ARTERY M Postula; A Serafin; M Marchel; K Filipiak; B Tarchalska; G Opolski;

P642POOR RESPONSIVENESS TO CLOPIDOGREL DRUG-SPECIFIC OR CLASS-EFFECT?A Frangione; S Luccarelli; G Campo; M Valgimigli; R Ferrari;

P643DETERMINATION OF PLATELET AGGREGATION IN PATIENTS WITH STABLE CORONARY ARTERY DISEASEON LONG-TERM ASPIRIN THERAPHYM Postula; A Serafin; K Filipiak; B Tarchalska;

P644EFFECT OF THIENOPYRIDINES DISCONTINUATION ON DEATH OR MI AFTER SES VERSUS BMS IMPLANTATION IN STEMIC Arcozzi; G Campo; G Percoco; R Ferrari; M Valgimigli;

P645PRO-ATHEROTHROMBOTIC EFFECTS OF CIGARETTE SMOKING

IN ENDOTHELIAL CELLS PROTECTIVE EFFECTS OF STATINSP Cirillo; M Pacileo; S De Rosa; A Gargiulo; R Spagnuolo; P Maietta; M Chiariello;

P646LEPTIN INDUCES A PRO-ATHEROTHROMBOTIC PHENOTYPE IN HUMAN CORONARYENDOTHELIAL CELLSS De Rosa; P Cirillo; M Pacileo; V Angri; G Petrillo; G Ucci; L Sasso; M Chiariello;

P647ACE INHIBITION WITH PERINDOPRILAND MARKERS OF ATHEROSCLEROSISAND THROMBOSIS: RESULTS OF THE PERTINENT STUDYC Ceconi; K M Fox; W J Remme; M L Simoons; M Bertrand; G Parrinello; C Kluft; D V Cokkinos; R Ferrari;

P648ECONOMIC ANALYSIS OF HIGH BOLUSDOSE TIROFIBAN AND SIROLIMUS-ELUTING VS ABCIXIMAB AND BARE-METAL STENT IN STRATEGYI STUDYP Squasi; C Arcozzi; F Basta; G Percoco; R Ferrari;

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MISCELLANEOUS

Moderators: D Mele (Ravenna, IT)B Ostadal (Prague, CZ)

P649HIGH-RESOLUTION MRI FOR CAROTID ARTERY PLAQUE CHARACTERIZATION USING DIFFERENT WEIGHTINGS AND FAT SUPPRESSIONC J A Van Echteld; B C M Te Boekhorst;M M Cramer; M F M Van Oosterhout; G Pasterkamp; P A Doevendans;

P650WIRELESS, SELF-GATED MULTI-SLICE CINE MRI OF MOUSE HEARTS IN VIVOC J A Van Echteld; B C M Te Boekhorst;M G J Nederhoff; K W A Van De Kolk; A Nauerth;

P651A NOVEL REAL-TIME IN VIVO 3D CONFOCAL IMAGING SYSTEM CAPTURES THROMBUS FORMATIONIN MOUSE TESTICULAR ARTERYH Ishida; N Higashijima; Y Takahari; Y Egchi; T Kadono; S Goto;

P652MANGANESE-ENHANCED MRI (MEMRI) OF CRYOINJURY TO PIG HEARTV Kupriyanov; Y Yang; J Sun; A Turner; M Gruwel;

P653CORONARY SINUS VISUALIZATION BY 3-DIMENSIONAL REAL TIME

ECHOCARDIOGRAPHYC Conca; A Auricchio; F Faletra; A Sorgente; O Chioncel; E Pasotti; G Pedrazzini; T Moccetti;

P654STUDY OF THE RAT HEART LOW - MOLECULAR METABOLITES BY MAGNETIC RESONANCE SPECTROSCOPYD Dobrota; E Babusikova; P Kaplan; N Pronayova; S Kasparova;

P655MANGANESE ENHANCED MRI OF MYOCARDIAL VIABILITY IN HUMANSP Jynge; A Skjold; H Brurok; H W Larsson;

P656ASSESSMENT OF ACUTE AND CHRONIC CARDIAC INFARCTION IN PIGS USING NEAR-INFRARED SPECTROSCOPIC (NIRS) IMAGINGV Kupriyanov; D Manley; Y Yang; B Xiang; O Jilkina; X Yang;

P657CHEMILUMINESCENCE (CL) OF MACROPHAGES FROM IHD PATIENTS AND HEALTHY DONORS BEFORE ANDAFTER INCUBATION WITH LDLM Bilenko; Y Vladimirov; S Pavlova;

P658THE EFFECT OF LOSARTAN ON TIME TO RIGOR OCCURRENCE OF DIABETIC CARDIOMYOCYTES

L Raimondi; C Alfarano; E Cerbai; A Mugelli;

Moderators: A Mugelli (Florence, IT)G Pelà (Parma, IT)

P659LIQUID-PHASE ISOELECTRIC FOCUSING OF CARDIAC PROTEINS: DIFFERENTIAL SEPARATION OF cMyBP-C PHOSPHORYLATION STATESK Sultan; L Pohlmann; D Juhr; T Eschenhagen; L Carrier;

P660 IN VIVO DIRECT DELIVERY OF BIOLOGICALLY ACTIVE PROTEIN INTO CARDIOMYOCYTES OF RATS AFTER ACUTE MYOCARDIAC INFARCTIONA Hatada; M Kaneko; M Kawago; Y Iwahashi; Y Nishimura; T Hiramatsu; Y Okamura; M Maeda;

P661 INVOLVEMENT OF Rab GTPases IN FLUVASTATIN-INDUCED VACUOLATION IN RAT SKELETAL MYOFIBERS K Sakamoto; T Honda; S Yokoya; S Waguri; J Kimura;

P662CARDIOVASCULAR DISTRIBUTION OF THE CALCIUM SENSING RECEPTOR BEFORE AND AFTER BURNS

119R J Bick; P Enkhbataar; D Traber; M Buja; C Jonkam; B J Poindexter; G L Klein;

P663GLUTATHIONE REDUCTASE AND VITAMIN B2 STATUS IN RED CELLS OF PREGNANT WOMENA Kozlovskaya; N Potolitsyna; E Bojko;

P664APPLICATION OF ANTI-HUMAN CTNI MONOCLONAL ANTIBODIES INEVALUATION OF RAT MYOCARDIAL INJURY MODELSZ Bian; D Yang; X Chen; J Xu; J Zhang;

P665OCCURRENCE AND RISK FACTORS FOR CABG INTERVENTIONS AFTER PTCA REVASCULARIZATIONI Craciunescu; G Pampu; M Serban; S Vasile; B A Popescu; H Moldovan; D Deleanu; C Ginghina;

P666TIMI RISK SCORE IN PATIENTS WITHUNSTABLE ANGINA/NON-ST

ELEVATION MI WHO UNDERWENT CABG REVASCULARIZATIONG Pampu; I Craciunescu; M Serban; S Vasile; H Moldovan; D Deleanu; C Ginghina;

P667 INTERRELATIONSHIPS OF FUNCTIONAL, BIOCHEMICAL AND MORPHOLOGICAL VARIABLES IN CATECHOLAMINE CARDIOTOXICITYP Mladenka; R Hrdina; Z Bobrovova; M Hubl; P Nachtigal; J Skrle; V Semecky;

P668MYOCARDIAL ISCHEMIA PREVENTION IN SWINE WITH AUTOLOGOUS OZONEIZED BLOOD TRANSFUSION A Barone; J Woskoboinic; A Grangeat; R Pérez; I Berra; G Berra; J Milei;

P669CARDIOPROTECTIVE EFFECT OF EXOGENOUS PHOSPHOCREATINE (NEOTON) IN THE HEART INJURIESOF DIFFERENT GENESIS

O Moybenko; V Datsenko; V Pavljuchenko; O Parchomenko;

P670ROASTED LICORICE EXTRACTS SUPPRESS CHRONIC HIGH GLUCOSE-INDUCED APOPTOSIS AND ENDOTHELIAL DYSFUNCTIONY Kang; Y Choi; J Choi; S Kang; J Bae; S S Lim;

P671 INCREASED PP1 AND PP2A MEDIATING REDUCED Ser16 PHOSPHORYLATED PLB IS A POSSIBLE MECHANISM FOR CARDIAC DYSFUNCTION IN ALVEOLAR HYPOXIAK O Larsen; I Sjaastad; B Lygren; G Florholmen; K A Krobert; K Arnkværn; F O Levy; O H Skjønsberg; K Tasken; G Christensen;

P672RELATION BETWEEN LOSS OF T-TUBULES, NA/CA EXCHANGE AND RYANODINE RECEPTOR FUNCTION IN MYOCARDIAL INFARCTION L Biesmans; F Heinzel; V Bito; M Wu; J D'Hooge; K R Sipido;

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THE ANSWERS TO THOSE QUESTIONS

If you attended the ISHR meeting in Rhodes you mightremember the “chaos theory”!

A congress in Italy…organized by two Italians?

Draw your attention to the paragraph overleaf on ChaosTheory!

You will definitely learn a lot about chaos in the next few days!

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EMERGENCY TELEPHONE NUMBERS112 - Carabinieri 113 - Emergency Police Help Number115 - Fire Department 116 - A.C.I. (Italian Automobile Club) road assistance 118 - Medical Emergencies

TELEPHONE AND INTERNET ACCESS International calls can be done from any downtown public telephone.Prepaid cards are cheaper to use for these calls. Internet cafes arequite popular and they can be found in the city centre. An InternetPoint will be available for participants within the main CongressArea.

MEDICAL CARE AND HEALTH INSURANCE For foreign travel, good medical insurance is advisable. However ourhealthcare system applies to everyone when in Italy. No particular vaccinations are required.

ELECTRICITY SUPPLYElectric voltage for home use is 220 volts 50 hz and sockets are eitherat three or two-ways (Schuko Type). Foreign appliances may requirean adapter.

EXCHANGE Foreign currencies can be exchanged at banks or foreign exchange offices.


CHAOS THEORYBologna 2007 will be a big event, and at times a little chaos may develop,especially in airports and the busy streets of Bologna. Chaos can bea source of intense irritation – alternatively, you could choose to viewit as a part of the Mediterranean cultural theatre that you have tra-velled so far to experience. So why not sit back, relax, and enjoy thespectacle while Gigi and Roberto endeavour to solve any problems asbest they can!

CHEQUES AND CREDIT CARDSPersonal cheques are not in general use. Credit cards are widely usedin urban areas. Shops and restaurants that accept credit cards havestickers at the entrance or signs posted elsewhere to indicate whichcards are accepted. Prepaid cards used in public telephone boothsand for other purposes are sold in most newspaper stands.

CLIMATE The weather in Italy during June is pleasant, general sunny andwarm, the average temperature is 24-28°C (82 F)

CASHIt is generally safe to carry cash in Bologna. Small amounts of cashare needed for most forms of transportation, small shops and forother small purchases.

CURRENCYThe official currency in Italy is the Euro(s). Coins are 1, 2, 5, 10, 20, 50cents and Euro 1 and 2. Banknotes are 5, 10, 20, 50, 100, 200, 500 Euros.Banking hours are 8:30 am – 1:30 pm and 2:30 pm – 4:30 pm. Openhours may slightly change from bank to bank in the afternoon. Banksare closed on Saturdays and Sundays.

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The XIX ISHR World Congress will also be the occasion to meet with professional organizations and major pharmaceuticalcompanies…we encourage you to have a walk around the Exhibition Area…

TRADE EXHIBITION

TO POSTERSAND FOOD

COURT

PRESSROOM

ISHR CONGRESSROOM

RECEPTION ANDREGISTRATION

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TO POSTERSAND FOOD

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cloakroom

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PC CENTER

21bis

SPONSORS

A. Menarini 20Abbott 17ADInstruments 21bisAstraZeneca 3 e 4Boehringer Ingelheim 18Chiesi 15Gardhen Bilance 8GE Healthcare 9I.F.B. Stroder 10ISHR 2010 - Japan 16ISHR Secretariat 13Merck Sharp & Dohme 19Pfizer 1 e 5Red Box Direct 14Schering Plough 11Scisense 21Servier 2 e 7Sigma-Tau 12VisualSonics 6

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ARRIVEDERCI: THE WHITE EVENING

On Monday 25 June at 20.00 we have organized a “White Evening”, an exceptional event which will be held in the center ofBologna where all of the University palaces will be opened especially for the ISHR, giving us the opportunity to experience thehistorical and architectural beauty of these buildings. The event is strictly reserved for participants to the 19th World Congress of the ISHR. Kindly show your badge at the entranceof the venues you wish to visit.

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1 - The Civic Archaeological Museum of BolognaVia Dell'Archiginnasio 2

It is located in the heart of the city, inside Palazzo Galvani,close to Piazza Maggiore and the Church of San Petronio. Thefirst construction of this building dates back to the XV century.Modifications and renovations continued up to 1881, when itwas definitively opened to the public as a Museum. You canreach the Museum using any bus that runs through PiazzaMaggiore.

2 - Santa Maria della Vita, Sanctuary and OratoryVia Clavature 10

The two architectural items, once in the heart of the bestknown hospital in Bologna, “Ospedale Maggiore”, founded in1287 by a congregation of so-called “Flagellants” or “battuti[beaten]”, host two extraordinary terracotta masterpieces:Niccolò dell’Arca’s Compianto su Cristo morto [Mourningover the dead Christ, 1463], which D’Annunzio described asa “cry in stone”, and Alfonso Lombardi’s Transito dellaVergine (The Virgin Mary’s way, 1522).

3 - Church of Santa CristinaPiazzetta Morandi

It was Napoleon who suppressed the prestigious nunnery ofthe Camaldolites, who had moved to the convent in the 12thcentury. The church, one of the most relevant architecturalobjects in Bologna after the Reformation brought by the


Council of Trent, became a military store. Napoleon’s actionwas the first stage of a long process of decay, concluded byrestoration works. It is therefore possible to admire anewmasterpieces such as L. Carracci’s Ascensione, D. M. Canuti’sSanta Cristina battuta dal padre [Saint Cristina beaten by herfather] or the first sculputers by a young Guido Reni.

4 - Convent of Santa CristinaPiazzetta Morandi

The complex, dating back to 1247, where the Camaldolesenuns from the Convent of Santa Cristina di Settefonti settled,was subsequently completed with important works. Thechurch, later destroyed by a fire, was re-built and the Cloisterwas given a 15th century aspect.By the late 16th century, the upper floor of the cloister and thearchitectonic decorations were completed. In 1626 theCamaldolese nuns were dismissed and Austin nuns also settledhere for a brief period in the 19th century. Afterwards, thecomplex hosted military barracks.In the 1990s the Bologna City Council purchased the area andrelevant restoration works began, such as the recovery of theoriginal flooring, of the 16th century paintworks and of thehypogean wash-houses. The convent was then assigned to theUniversity of Bologna.Currently, one wing of the first floor hosts a library, while theground floor was transformed into a number of classrooms,and the old refectory is now the Aula Magna.

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5 – The Oratory of San Filippo Neri The oratory of San Filippo Neri was designed and built byAlfonso Torreggiani, who worked on this project for about tenyears, from 1723 to 1733. Access to the oratory is from via Manzoni (formerly viaGalliera) through a sixteenth-century doorway, probablytaken from one of the houses of the Hercolani family. The hallof the oratory is an excellent example of architectural anddecorative plans, due to the simultaneous carrying out of thebuilding by Torreggiani and of the inside decorations by agroup of talented artists: the sculptor Angelo Piò, the plastererCarlo Nessi, the carver Antonio Calzolari and the painterFrancesco Monti.Just two paintings have survived destruction: Christ crowned ofthorns and shown to the people by Ludovico Carracci and TheMadonna and Child in Glory with St. Barbara and St. FilippoNeri by Francesco Monti. Ludovico Carracci's fresco is located onthe south wall, just above the entrance.

6 – The Archiginnasio Piazza Galvani, 1

The former venue of the University of Bologna, it was built in1562-1563. The building design was planned by the Bolognesearchitect Antonio Morandi known as “il Terribilia”. The two-storey building is fronted by a long 30-arch portico anddevelops around a central courtyard surrounded by a two-tieredloggia. Two imposing stairways lead to the upper floor, hosting:


SALA DELLO STABAT MATER

The most representative of the old University venue, as it islavishly decorated with several gratulatory items that sometimesoverlap older ones.

ANATOMICAL THEATER

The room, shaped as an amphitheater was designed in 1637 tohost the anatomical lectures delivered by the Bolognese architectAntonio Paolucci known as “il Levanti”, a pupil of the Carraccis.The room was built with fir wood and decorated with two rowsof sculptures. The lower order included the statues of twelvefamous physicians while the upper series of statues portrayedtwenty of the best-known anatomists of the University ofBologna.The coffered ceiling is decorated with symbolic representationsof fourteen constellations surrounding the central figure portraying Apollo, tutelary deity of medicine. The teacher’s desk is flanked by two statues, the “Spellati”[Skinned bodies], carved in 1734 following the drawings byErcole Lelli. Above the canopy, a winged putto hands a femurinstead of a flower as a present to a seated female figure, theallegory of Anatomy.The anatomical classroom was heavily damaged by the bombings in 1944, but it was rebuilt soon after the war, withthe original wooden sculptures, fortunately recovered amongthe ruins.

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INDEX

Find out what you are doing, and how many presentations your “competitors” are making!!!

speaker (listed per lecture no.)chairman (listed per page no.)poster moderator (listed per page no.)moderated poster (listed per poster no.)

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AAasum E P173Abd Allah E P4Abd-Elfattah A S P478Abd-Elfattah A S P550Abellan A P297Abi-Gerges A P135Abi-Gerges A P351Abrenica B P203Abrenica B P366Abriel H P11Adachi-Akahane S P102Adameova A P552Adameová A P553Adamo C P68Afzal F P414Agnetti G P435Agnoletti L P617Agnoletti L P618Agullo E P330Ahmed A H P427Ahmed A H P428Ahmed M P548Ahmed M S P335Ahmet S P239Aiello E A 96Aiello E A 107Aizaki Y P137Akagami T P84Akagami T P121Akagami T P132Akazawa H P81Akazawa H P337Akcay T P597Akki A P383Aksentijevic D P151Aksentijevic D P185

Aksentijevic D P381Akutagawa O P410Akutagawa O P421Alatawi N P74Alboni P 41Alemanni M P375Alfarano C P658Alfieri O 96Ali N N P239Aljabri M B P501Aljawarneh Y M P584Allen B P180Allen D P58Allen D G P291Allen D G P449Alloatti G P288Alom Ruiz S P P603AlShaaban M A P366AL-Shamayleh Q P584Altomare C P242Altun A P95Aluko R P361Alvarez J P104Aly H P478Amber F P70Ambrosio G P221Ambrosio G P262Ambrosio G 37Ambrosio G 253Ambrosio G 76Ambrosio G 110Amran S P2Anand I 74Anand I 185Anand I 52Anand I 90Anand I 102Anderson M E P99Andersson K B P287Andersson K B P289

Andrag E P310Andreadou I P459Andreadou I P485Andreasen T V P481Andreasen T V P501Andreotti F 77Andressen K W P414Andriantsitohaina R P346Andriantsitohaina R P347Angelini A P243Angelini A P275Angelini A P358Angelini A P424Angelini A 36Angelini A 60Angelini A 74Angelini G D P522Angelone T P68Angelone T P303Angelone T P332Angeloni C P515Angelovska T P140Angoulvant D P269Angri V P646Anker S D 106Anker S D 189Antenucci E P436Antequera R P344Antonopoulou E P552Antonopoulou E P553Ao L P542Ao L P543Ao L P635Aoki S P468Aon M P298Arai M P107Arai M P214Arandarcikaite O P578Arbustini E 47Arbustini E 60

Arbustini E 65Arbustini E 104Arca M 113Arca M 29Arcozzi C P644Arcozzi C P648Ardesi R P528Ardissino D 81Armstrong S C P450Armstrong S C P451Arnkværn K P671Aronsen M P414Arora M P134Arora R P263Aroutiounova N P237Arpesella G P267Artale P P61Artale P P62Artale P P63Artale P P432Artale P P433Artale P P434Asai K P468Asaumi Y P406Ashford D A P160Astolfi A P201Astolfi A P393Atar D 80Athéa Y P189Athias P P6Athias P P527Athias P P599Attramadal H P335Attramadal H P548Augstein A P206Aukrust P P416Auricchio A P422Auricchio A P653Auricchio A 71Auricchio A 49

Auslander S P257Ausoni S P274Averna M P296Avkiran M P14Avkiran M P115Avkiran M P116Avkiran M P117Avkiran M P127Avkiran M P534Avkiran M 133Avkiran M 66Avkiran M 98Aydt E M P340Azimzadeh A M P387

BBabiker F A P326Babusikova E P18Babusikova E P322Babusikova E P654Bachetti T P614Bachetti T P615Bachetti T P617Bachetti T P618Backx P H P105Bacurau A V P396Bae J P670Bae J Y P222Baetz D P357Bahi L P189Bai Y P64Bak I P576Balakin A A P308Baldo E P61Baldo E P62Baldo E P63Balkova P P519

129Baniene R P295Banke N P174Barancik M P24Barassi P P375Barauna V G P360Barauskaite J P578Barbash I M P256Barbash I M P264Barbieri S P332Bardswell S C P78Bardswell S C P116Barile L P242Barile L P247Barile L P273Baron J P264Barone A P668Barrows B R P387Barta J P125Bartel S P71Bartel S P86Bartel S P106Barton P J R P400Barton P J R 31Baruscotti M P39Barzelai S P254Basso C 250Basso C 115Basta F P648Bastianon D P614Bastianon D P616Bastianon D P617Bastianon D P618Basu S P547Bathe K L P336Baudoin F P74Bauer M P200Bauer M P407Bauer M P549Bauernschmitt R P352Bauersachs J P252

Bauersachs J P420Baxter G F 80Baxter G F P133Baxter G F P531Baxter G F P539Baxter G F P555Baxter G F P572Baxter G F P586Bedosky K M P204Bekyarova T P324Belaïdi E P517Belardinelli L P29Belardinelli L P52Belardinelli L 223Belardinelli R 207Bell D P91Bell D P355Bell D P365Beltrami A P 100Beltrami C A 38Beltrami C A 78Bencsik P P280Benitah J P8Benson V L P529Bentzen B H P47Berdeaux A P305Berdeaux A P590Berdeaux A P596Béréziat G 141Béréziat G 67Béréziat G 86Berg K P547Berge R P173Bernardi F 101Bernardi F 117Bernardi P 94Bernatova I P342Bernatova I P345Bernatova I P346Bernatova I P347

Bernatova I P349Berni R P268Berra G P668Berra I P668Berrino L P202Berrino L P227Berry R G P59Bers D 42Bertaggia D P286Bertini E P198Bertok S P499Bertrand L P144Bertrand M P619Bertrand M P647Besch H R P44Besik J P532Besikci A P462Bessho R P557Bessho R P558Bessho R P574Betocchi S P298Bettini M P262Bettiol E P245Bettiol E P246Bhamra G S P594Bhandari S P151Bhandari S P160Bhandari S P185Bhandari S P381Bhatnagar A P488Bhatnagar A P541Biagi P P515Biagiotti L P241Biamino G 96Bian J P469Bian Z P518Bian Z P664Bick D L P225Bick R J P662Biesiadecki B 176

Biesmans L P672Bilbault J P6Bilenko M P657Bilginoglu A P70Bilginoglu A P441Bilginoglu A P462Bilinska Z P399Binczac S P6Birkeland J A P287Birks E P400Biscottini E P262Bishopric N H 163Bishopric N H 82Biswas S K P230Bito V P103Bito V P672Bize A P305Blaauw E P326Blaha V P425Bleiziffer S P352Boateng S Y P370Bobik A P261Bobrovova Z P667Bocchi L P268Bodi I P100Bodi I P301Boengler K P330Boengler K P497Bojko E P663Boknik P P57Bolli R P494Bolli R P541Bolli R 137Bolli R 32Bolli R 96Bolognese L 82Bonafé F P238Bonnet N P600Bonnet P P623Bonny C P148

Boontje N M P125Bootman M D 41Bootman M D 57Booz G W P138Bopassa J C P527Borchert G H P105Borchi E P418Borchi E P556Bordoni A P201Bordoni A P393Borer J 31Borer J 73Borgers M P326Borghi C 107Borghi C 114Borghi C 84Borgia F P368Borgia F P404Boriani G 44Borutaite V P578Boscà L P545bosch R F P57Böse D P634Bouchard B P172Bouly M P36Bouly M P528Bourreau J P P110Bouvier M 204Boyett M P4Boyett M P126Boyett M R P41Boyett M R P51Bozcali E P597Bracco S P274Bracken N P43Brandes R P 198Branzi A 39Branzi A 46Branzi A 93Braun-Dullaeus R C P206

130Braun-Dullaeus R C P610Braunlich S 218Braunschweig F 130Brennan J P P114Brero A P288Brette F P3Brewer A P389Brewer A P603Brewer A M P427Brewer A M P428Briec F P8Brink P P196Brogioni S P29Brogioni S P60Brogioni S P108Brogioni S P250Brouns A E P354Brown D A P474Brown J H P99Brown J H P231Brown J H P233Brown J H 160Brown J H 81Brown M D 102Brum P C P396Bruneau B G 181Bruneau B 85Brunetti D P216Brurok H P547Brurok H P655Brutsaert D 92Brutsaert D 102Brutsaert D 108Bucchi A P39Buckingham M 183Buechert A P497Bueno O P P87Buisson B P596Bui-Xan B P38Buja L M P225

Buja L M P258Buja M P662Bulmer K P160Burgoyne J P114Burkin D J P42Burlacu A P248Burlacu P253Burley D S P572Burley D S P586Buroker N E P90Buyse G P448Byrne M P216

CCabestrero A P329Cabestrero A P330Cabrera Aguilera C P311Cabrera Aguilera C P314Cabrera Aguilera C P193Cabrera M P179Caforio A P243Cagalinec M P171Cai L P607Caimmi P P P304Caldarera C M P197Caldarera C M P241Caldarera C M P267Caldarera C M P435Caldarera C M 95Campanile A P580Campanile A P606Campo G P638Campo G P642Campo G P644Campos P M P141Cannel M B P461Cannell M P58

Canton M P325Canton M 14Canton M 109Cao J P316Cao Y P285Capasso E P368Capetanaki Y P444Capetanaki Y P445Capetanaki Y P446Capogrossi M C 76Capogrossi M C 136Cappato R 73Cappello S P303Capuano V P101Capucci A P429Capucci A P430Carboni M P238Carboni M P267Cardoso C P340Cargnoni A P528Carotenuto F P181Carotenuto F P251Carpenter G P511Carpi A P195Carpi A P286Carr C A P240Carr R P594Carreira R P165Carreira R P166Carreira R P167Carrier L P294Carrier L P364Carrier L P455Carrier L P659Cartwright E J P74Cartwright E J P374Caruso C P197Caruso G 31Carvajal K P159Casadei B P111

Casadei B 85Casadei B 54Casado M P545Cass D P435Casscells S W P427Casscells S W P428Castellani C P243Castellani C P275Castriota F 63Castro L R V P351Catapano A L 2Caton J P625Cattini P A P212Cattini P A P236Cavalcanti S P241Cazzato A P472Cecaro F P432Cecaro F P433Cecaro F P434Ceconi C P36Ceconi C P432Ceconi C P433Ceconi C P434Ceconi C P436Ceconi C P438Ceconi C P439Ceconi C P440Ceconi C P528Ceconi C P614Ceconi C P615Ceconi C P616Ceconi C P619Ceconi C P647Ceconi C 3Ceconi C 115Ceconi C 246Ceconi C 88Cena J P320Cerbai E P17Cerbai E P29

Cerbai E P36Cerbai E P60Cerbai E P83Cerbai E P108Cerbai E P245Cerbai E P246Cerbai E P250Cerbai E P418Cerbai E P629Cerbai E P658Cerbai E 33Cerbai E 224Cerbai E 48Cerisoli F P273Cerra M P68Cerra M C P303Cha J P542Chakir K P394Chakir K P435Chambers D J P78Chandler N P126Chaponnier C P326Charles C J P21Charles C J P96Charles R P184Charpentier F P8Charron G P172Chase A P522Chatham J C P177Chavey A P144Chelly B P413Chen J P289Chen J 44Chen J 60Chen L P65Chen L P369Chen P 232Chen R P447Chen R P612Chen S P611

131Chen X P518Chen X P664Chen Z P76Cheng H P54Chepurko Y P460Chepurko Y P535Chepurko Y P595Cherdon C P92Chess D J P376Chevalier P P38Chiappelli M P197Chiariello M P221Chiariello M P298Chiariello M P368Chiariello M P404Chiariello M P438Chiariello M P440Chiariello M P645Chiariello M P646Chicco A J P175Chicco A J P426Chicha L P246Chiellini G P60Chiellini P108Chien K R P289Chien K P622Chioncel O P653Chlopicki S P609Chmielinska J J P313Chmielinska J J P458Cho W J P320Choi J P670Choi J S P222Choi Y P670Choi Y J P222Chorvat D J P171Chouraqui P P264Chow A K P320Chreih R M P546Christ T P27

Christ T P57Christensen G P287Christensen G P289Christensen G P416Christensen G P671Christensen L P P563Christopher T P554Christopher T L P627Chun W T P493Chung K Y P85Chvojkova Z P532Ciccarelli M P580Ciechanover A 262Cirillo P P645Cirillo P P646Clark J E P143Clark J E P145Clarke K P192Clarke K P240Clarke K 58Clarke S J P484Claydon T W P51Cleland J G F 128Cleland J G F 93Clerk A P228Clerk A 72Clerk A 76Cleveland J C P543Coccaro E P207Coccolo F 105Cohen M S P127Cohen M V P487Cohen M V P509Coirault C P294Coirault C P302Coiro S P262Coker S J P20Cokkinos D V 106Cokkinos D V P88Cokkinos D V P401

Cokkinos D V P402Cokkinos D V P477Cokkinos D V P544Cokkinos D V P579Cokkinos D V P619Cokkinos D V P647Colantuono G P472Colin P P305Colson B A P324Comini L P36Comini L P358Comini L P615Comini L P616Comini L 115Conca C P422Conca C P653Condorelli G P216Conforti L P100Conklin D P541Consoli A 150Consoli A 154Consoli A 70Constantinou M P459Conti M P135Cook A P14Cook A P534Cooper G P371Cooper G J S P461Copeland O P199Corbaz C P11Corder E P197Cortès-Morichetti M P294Cosentino F 148Cossa P P181Cossa P P251Costa A D P122Costa A D T P128Costello C E 17Cotella D P30Couvreur N P590

Cozzi E P274Craciunescu I P665Craciunescu I P666Craig R P334Cramer M M P649Crandall D L P87Crawford B D P320Cremonesi A 60Cremonesi A 38Crespo P P141Croquelois A P367Cruz-Robles D P159Csanády M P9Csanyi G P609Cserepes B P499Csík N P15Csík N P19Csizmadiova Z P345Csonka C P490Csonka C P508Csont T P280Csont T P479Csont T P490Csont T P508Cuello F P114Cuello F P115Cuello F P116Cuello F P127Cuello F 177Cui L P487Cunnington R H P204Curl C L P362Curl C L P379Curtis D P261Curtis M J P14Curtis M J P310Curtis M J 230Curtis M J 109Czibic G P548Czubryt M P P203

Czubryt M P P366

DD’Anglemont A P596D'Agostino D P472Dahln M B P475Daiber A P252Dalla Libera L P423Dalla Libera L P424Dalla Paola L 217Damas J K P416D'Amati G P418Damiano E P202D'Amico A P198Damy T P302Danesi F P201Danesi F P393Dangerfield A L P336Daniel E E P320Danieli D P424Darmellah A P357Dart A M P583Das D 166Das D 30Das D 89Das D P486Das D P513Das D P575Das D P576Das M P486Das S P486Das S P575Das S P576Dati C P288Datsenko V P669Daubert J C 69Daverio P 27

132Davidson S M P465Davidson S M P525Davidson S M P569Davidson S M P593Davidson S M P594Davies L P164Davies R J P145Dayan A P182Dayan A P254Dayan A P257De Angelis M C P368De Angelis M C P404De Caterina R 251De Caterina R 114De Feyter P J 100De Gennaro S P580De Leval L P92De Rosa S P645De Rosa S P646De Tullio R P296DeBosch B P234Decarli A P439Dedja A P274Dedkov E I P563Defraigne J O P92Del Lungo M P17Del Monte F P417Del Prato S 151Del Prato S 71Del Re D P P231Delbridge L M D P379Delbridge L M D P10Delbridge L M D P362Delbridge L M D 94Delbridge L M D 145Delbridge L M D 44Delcayre C P37Delcayre C P278Deleanu D P546Deleanu D P665

Delenau D P666Delgado R M P427Delgado R M P428Della Barbera P275Della Barbera M P243Demirci C P476Deng C P341Deng J P263Dent M R P75Der P P570Des Rosiers C P180Des Rosiers C P172Deschepper C P180Deslauriers R P263Detré E A P103Devillard L P527Devillard L P599Dhalla N S P75Dhalla N S 75Dhalla N S 80Dhingra S P229D'hooge J P448D'hooge J P672Di Francesco D 32Di Francesco D 47Di Lisa F P195Di Lisa F P286Di Lisa F P307Di Lisa F P325Di Nardo P P181Di Nardo P P251Di Nardo P P279Di Nunzio M P201Di Nunzio M P393Di Pasquale G 29Di Venosa N P472Diaz R P118Diaz-Meco M T P123Dick G M P44Dietl W P200

Dietl W P407Dietl W P549Diez J 65DiFrancesco P39Dimopoulos A P402Dimopoulos A P477Dimopoulos A P544Dincer U D P44Dincer Y P597Ding M P550Dixon I M C P140Dixon I M C P204Dixon I M C P336Dixon R A P568Dlugosova K P22Dlugosova K P33Dlugosova K P621Do H P636Dobrev D P57Döbrönte R P154Dobrota D P322Dobrota D P654Dobrzynski H P4Dobrzynski H P41Dobrzynski H P126Doetschman T P540Doevendans P P649Dogné J M P92Dogné J M 101Dogné J M 116Doi T P84Doi T P132Domenighetti A P271Domenighetti A P367Donat U P500Dörge H P551Dorobantu M P248Dos Remedios C G P398Doursout M F P413Downey H F P25

Downey H F P491Downey J 40Downey J P487Downey J P509Dragan E P253Drelicharz L P609Drews O P339Drexhage C P531Drexler H 186Drexler H 249Drexler H 45Driesen R B P326Drimal J P33Drion P V P92Drobic V P140Drouot C P596D'Souza K P100D'Souza K P301Du J P323Du Toit E F P155Du Toit E F P480Du Toit E F P562Du X P390Du X J P411Du X J P583Dubuis E P43Dubuis E P53Duda M K P176Duda M K P384Dumont L P599Dusting G J P630Dyck J R B P530Dyer E P442

EEaton P P114Eaton P P184

Eaton P 16Eaton P 55Eder V P623Edvardsen T P335Edvardsen T P548Eerbeek O P476Egchi Y P651Eichhorn B P604Eikemo H P146Eimre M P191Eisner D 36El Phyu H P163El-Akawi Z J P584Elkadri M P53Elliot P435EL-Mezgueldi M P452Elsaesser A P405Elsaesser A P431Elsey D J P539El-Yazbi A F P320Emanuel K P111Engelbrecht A P514Engelbrecht A M P562Engelhardt S P135Engelhardt S P534Engelhardt S 201Engelhardt S 51Engelhardt S 94Englert A P71Englmann D P455Engstrøm T P498Enkhbataar P P662Epstein J 182Erbel R P634Erhardt L 92Ertl G P252Ertl G P420Eschenhagen T P99Eschenhagen T P364Eschenhagen T P455

133Eschenhagen T P659Eschenhagen T 100Escoubet B P8Escriba P V P105Esposito B P600Esposito G P404Essop M F P190Esterhuyse J P562Eteraf Oskouei T P28Evangelista F S P396

FFacchini M P7Failli P P629Faircloth M E P145Faletra F P653Faletra F P422Fallouh H B P78Falzetti F P262Fan H P526Fan L P79Fandrich R P237Fandrich R P353Fang L P583Farag N E P51Farell S R P66Farkas A P9Farkas A P9Farkas A P15Farkas A P15Farkas A P19Farkas A P19Favale S 66Favilli R P556Federici A P472Feenstra H M P395Fei H P170

Felix S P147Felix S P500Felkin L E P400Felley A P271Fellin R 37Fenning A P163Fenning A P164Ferdinandy P P26Ferdinandy P P50Ferdinandy P P133Ferdinandy P P280Ferdinandy P P479Ferdinandy P P490Ferdinandy P P508Ferdinandy P P586Ferencz S P499Ferguson J H P482Ferko M P168Ferrari P P375Ferrari R P36Ferrari R P61Ferrari R P62Ferrari R P63Ferrari R P255Ferrari R P358Ferrari R P436Ferrari R P437Ferrari R P438Ferrari R P439Ferrari R P440Ferrari R P528Ferrari R P614Ferrari R P615Ferrari R P616Ferrari R P617Ferrari R P618Ferrari R P619Ferrari R P642Ferrari R P644Ferrari R P647

Ferrari R P648Ferrari R 214Ferrari R 35Ferrari R 46Ferreira J C B P396Ferrera R P269Ferrera R P527Ferron L P101Feuvray D P357Fiaccavento R P181Fiaccavento R P251Fiaccavento R P279Fialova M P22Fialova M P33Fialova M P621Fiedler J P420Fields A P372Filice E P68Filice E P332Filip S P259Filipiak K P639Filipiak K P640Filipiak K P641Filipiak K P643Findlay I P56Finsen A V P289Finsen A V P416Fiore T P472Fischmeister R P135Fischmeister R P136Fischmeister R P351Fischmeister R 88Fischmeister R 54Fisher A P186Fitzsimons D P P324Fiumana E P267Flaherty D C P491Flameng W P492Flashman E P312Flavell R A P145

Fleming I 167Fleming I 89Fliegel L P207Fliegel L P380Florholmen G P671Foldes G P386Ford I P437Foroni L P238Foroni L P267Forster T P9Förster K P147Forte E P273Forte G P181Forte G P251Fortin D P189Fortuño A 12Fotopoulou T P485Fowkes R C P531Fowkes R C P539Fox K P437Fox K 34Fox K P619Fox K P647Fraccarollo D P252Franchi-Micheli S P629Francolini G P614Francolini G P616Francolini G P617Francolini G P618Franczyk M P609Frangione A P638Frangione A P642Franzoni M P201Frascarelli S P108Fratz S P352Free P P184Freed D H P140Frias M A P31Frigessi A P416Froehlich J P298

Fu F P359Fu F P526Fu F P588Fu F P592Fu Y P170Fu Y P341Fu Z P411Fucili A 90Fugarevici M M P248Fuglesteg B N P481Fuglesteg B N P501Fujii M P557Fujii M P558Fujii M P574Fujii T P260Fujio Y P131Fujio Y P533Fukaya H P32Fukaya H P464Fukuda K P187Fukuda K 99Fukuda K 78Fuller G P100Fuller W P72Fuller W P150Fullerton D P635Fullerton D A P542Fullerton D A P543Fulop N P177Fung M L P284Furst S P280

GGaballa M P265Gaballa M P266Gaetani R P247Gaetani R P273

134Gafencu A V P602Gaffney P R J P184Gaitani S P432Gaitani S P434Gajda M P609Galante A P279Galli C P216Galli G L J P292Gallo M P288Gallon C P456Galski H P264Galuppo P P420Gamberini C P238Gambino A P243Gan T P380Gan X T P373Gao F P156Gao F P559Gao F P560Gao F P561Gao F P627Gao H P65Gao L P220Gao L P564Gao X P390Gao X M P411Gao X M P583Garcia-Dorado D P297Garcia-Dorado D P329Garcia-Dorado D P330Garcia-Dorado D P545Garcia-Hoz P123Gardier S P148Gardner R T P175Gargiulo A P645Gargiulo G P221Garjani A P34Garlid K D P122Garlid K D P128Garnier A P189

Gastineau M P232Gateau-Roesch O P269Gattuso A P68Gautel 45Gavazzi A 127Ge M P90Geiszt M 10Gélinas R P172Gellen B P8Genade S P480Geng Y J P258Genis A P480Gensini G F 50Gensini G F 153George J P257Gepstein L 97Gepstein L 79Gerber-Wicht C P31Gergs U P89Gerosa G P243Gervais-Taurel M P590Gesztelyi R P94Gesztelyi R P570Gesztelyi R P571Geszthelyi R P575Ghaleh B P305Ghaleh B P590Gharekhani A P34Gharib A P496Ghatta S P601Ghatta S P625Ghatta S P632Ghavimi H P34Ghelardoni S P108Gheorghiade M 75Ghio S 70Giacomello A P242Giacomello A P247Giggey M P105Ginghina C P546

Ginghina C P665Ginghina C P666Giordano E P241Giordano E 30Giordano E 85Giraldo A P228Giricz Z P133Giricz Z P479Giricz Z P586Gitti G P528Gitti G P614Gitti G P616Gizas V P485Glogowski M P188Glogowski M P263Godin-Ribuot D P517Golcea S P438Golcea S P439Golcea S P440Goldman S P266Goldstein B P554Golovko V P1Gomes A V P339Gomes A V P536Gomez A P8Gomez L P496Goncalves L P165Goncalves L P166Goncalves L P167Gonçalves L P566Gönczi M P473Goosen A P196Gorbe A P133Gorbe A P280Gorbunov N V P513Gorelik J P417Goto S P651Goumon Y P332Govoni M P241Graber K R P450

Graber K R P451Graiani G P268Grammer J P352Grandy D K P108Grangeat A P668Grant P J 108Grant P J 70Gravning J P548Gravning J P335Graziano C P198Greaser M L P149Gres P P307Gres P P505Grieve D P389Grimaldi S P247Grimm M P99Grossini E P304Grunnet M P47Grunnet M P49Gruwel M P263Gruwel M P652Grynberg A 206Guardigli G P432Guardigli G 102Guarnieri C P238Guarnieri C P241Guarnieri C P435Guarnieri C 30Guellich A P294Guellich A P302Guerriero R P221Guiard J P364Gullestad L P416Günther S P89Guo L P317Guo W Y P559Guo W Y P561Guo Y P397Guo Y P494Guo Y P541

Gurdal P70Gurdal P626Gurel E P476Gur'ev W Y P308Gurusamy N P513Gussakovsky E P315Gutterman D 165Guvåg S P507Guyot V P269Guyton R P503Guzmán-Bárcenas J P208

HHaas S J P350Haase H P104Haase H P340Haaverstad R P547Habodaszova D P171Hadj A P350Hafstad A D P173Hajjar R P600Hajjar R 261Halestrap A P P321Halestrap A P P484Hall A 118Hall A 159Hall A 71Hall A 85Hall A P150Hallstroem S P549Hamid S A P531Hamm C W 83Hamon M 43Han B P592Han Q P64Han Q P139Han T P290

135Han W P411Han Y P244Hanft L M P124Hannan S P478Hanson J P92Hara Y P356Harding S 109Harding S 125Harding S 202Harding S 51Harding 94Harding S P55Harding S P134Harding S P239Harding S P240Harding S P318Harding S P417Harney J P178Harrap S B P362Harris B S P205Harris D P265Harris J P495Hart G P43Hart G P53Hartmann H P126Hartner W P587Hasenfuss G 222Hasenfuss G 258Hata T P410Hata T P421Hatada A P309Hatada A P660Hatton W J P42Hausenloy D 107Hausenloy D P465Hausenloy D P471Hausenloy D P483Hausenloy D P495Hausenloy D P506Hausenloy D P593

Hausenloy D P594Haworth R A P194Haworth R S P116Haworth R S P117Hayward C P398Headrick J 55Headrick J 37Headrick J 55Headrick J P512Headrick J P523Hearse D J 1Hearse D J 39Hearse D J 49Hearse D J 93Hearse D J 106Heimburger M P385Heinen Y P497Heinzel F P672Helgeland E P507Hemalatha T P582Henderson S A P290Henrion D 158Henry R P377Heradien M P196Herijgers P P69Herijgers P P388Herijgers P P448Herijgers P P492Hernandez L P159Hernando V P545Herranz M P123Hescheler J 98Hesketh G G P397Hess J P352Hetzer R P71Heusch G P77Heusch G P307Heusch G P329Heusch G P330Heusch G P497

Heusch G P505Heusch G P613Heusch G P634Heusch G 20Heusch G 34Heusch G 74Heusch G 107Hewitt K A P390Heymes C P351Hicks M P220Hicks M P564Higashijima N P651Higuchi M P161Hikoso S P338Hikoso S P409Hilfiker-Kleiner D P497Hill B P541Himmetoglu S P597Hinek A P118Hiramatsu T P309Hiramatsu T P660Hirano K P608Hiraoka M 49Hiraoka M 68Hiraoka M 73Hirasawa S P463Hlavackova M P516Hochhauser E P460Hochhauser E P535Hochhauser E P595Hoek F P152Hoit B D P176Hoit B D P384Holbova R P249Hollmann M W P476Holotnakova T P168Holt A P320Homma N P2Honda T P661Hongo K P109

Hool L 53Hool L 56Hori M P131Hori M P338Hori M P409Hori M P533Hori M P608Hori M 37Hori M 98Horio Y P223Hoskins A C P328Hossain T P118Hothersall J P525How O J P173Howlett S E P66Howlett S E P466Howlett S E P482Howlett S E P538Hrdina R P667Hrelia S P515Hu D Y 96Hu L P469Hu R P213Huang C X P373Huang X P129Huang X P170Huang X P323Huber J P580Hubl M P667Huggins C 68Huggins C P10Huisamen B P521Huliak I P133Huliák I P26Huliák I P50Hume J R P42Hunyor I P192Husberg C P416Hussain M P43Hussain M P53

Hussain R I P97Huttunen H J P219Huysmans C P103Hyvelin J P623Hyyti O M P90

IIaccarino G P580Iaccarino G P606Iaccarino G 67Idikio H P82Idikio H P581Ignarro L J 26Ignarro L J 35Iliceto S 257Iliceto S 72Iliodromitis E P485Iliodromitis E 106Iliodromitis E P459Ilves M P386Imanaga I P12Imbrogno S P68Inada E P79Inada S P126Inagami T P137Ingwall J 228Inomata T P306Inserte J P545Irigoyen M C P360Irving T C P324Isbrandt D P186Isbrandt D P192Ishida H P651Ishihata A P628Ishiko K P121Isobe K P412Isobe M P412

136Ito H P598Itzhaki A P256Ivanes F P269Ivanova M P24Iwahashi Y P309Iwahashi Y P660Izmar S P219Izumi M P533Izumi T P32Izumi T P306Izumi T P463Izumi T P464Izumi-Nakaseko H P102

JJackson C L P522Jaconi M P245Jaconi M P246Jacques A P199Jacques A P419Jacques A P456Jacques A P328Jacquet S P144Jacquir S P6Jahangir A P193Jahangir A P311Jahangir A P314Jaisser F P8Jakab A P94Jakab A P571Jancso G P280Jancso G P499Jang Y P224Jang Y P577Janssen B J P354Jaquet K P453Jardine D L P21

Jardine D L P96Jasik M P157Jasik M P158Jasik M P348Jawien J P609Jekabsone A P578Jendekova L P342Jendekova L P343Jenner T L P93Jennings R B 69Jeong M Y P363Jespersen T P11Jespersen T P49Ji G P76Ji L P403Jia G P560Jiang C P218Jiang R P503Jiang Y P611Jiao J P35Jiao X Y P554Jilkina O P169Jilkina O P188Jilkina O P315Jilkina O P656Jin H P213Jin Y P212Johnson J A 244Johnson M L P601Johnson P P523Johnson W B P318Jonassen A K P507Jones C P225Jonkam C P662Jordan M C P290Jordan N P367Jorge I P329Jost N P46Ju Y P58Jugdutt B I P82

Jugdutt B I P581Juhasz B P94Juhasz B P570Juhasz B P571Juhasz B P576Juhász L P26Juhász L P50Juhr D P659Jurado-Pueyo M P141Jynge P P547Jynge P P655

KKadaja L P191Kádár K P281Kadono T P651Kagaya Y P406Kaiserova K P488Kaljusto M P475Kalka C 220Kaludercic N P195Kaludercic N P298Kalyanasundaram A P16Kambe M P557Kambe M P558Kambe M P574Kane K A P20Kane L A P435Kaneko M P309Kaneko M P660Kanellakis P P261Kang S P670Kang S W P222Kang Y P670Kang Y H P222Kaplan P P18Kaplan P P322

Kaplan P P654Kappenberger L 72Karageorgiou H P477Karczewski P P106Kardami E P237Kardami E P336Kardami E P353Kardami E 19Kareem S P632Karmazyn M P373Karmazyn M P380Karnafel W P157Karnafel W P158Karnafel W P348Karsai D P570Kashour T P263Kasparcova V P87Kasparova S P654Katano Y P628Kato K P276Katugampola S P318Katz A P182Kawada T P408Kawago M P309Kawago M P660Kawai M P109Kaye D P216Kaye D M P537Kecskemeti V P13Keller D P11Kelly D P P174Kelly D P 255Kelly D P 111Kelly M P457Kelso E J P91Kennington E J P72Kentish J 36Kentish J 52Kentish J P78Kentish J P116

Kentish J P328Keravis T P136Keul P P613Khachigian L M P529Khairallah R P180Khalid A M P173Khaliulin I P484Khan M P270Khaper N P229Kharche S P3Kharchenko O P565Khatib S Y P585Khazi Syed R H P193Khmelnitskaya K A P631Khmelnitskaya K A P633Kijima Y P410Kijima Y P421Kim H P591Kimura J P661Kin H P503Kiriazis H P390Kirshenbaum L 162Kiselnik D P13Kiss A P26Kiss A P50Kitakaze M 210Kitakaze M 113Kitsis R N 161Kitsis R N 72Kitsis R N 76Kizaki K P356Kléber A 231Klein G L P662Klein H 171Kleinz M J P555Klöckner U P89Kluft C P619Kluft C P647Knecht S 47Knecht S 89

137Kneitz S P420Knezl V P18Knezl V P22Knezl V P33Knoell R 46Knott L P164Koch W J P394Kockskämper J P142Kockskämper J 40Kocsis F G P479Kögler H P142Koitabashi T P306Kojsova S P342Kojsova S P343Kokkinos A P477Koksoy A P441Koksoy A P462Koksoy A P624Koksoy A P626Kolar F P24Kolar F P105Kolar F P516Kolar F P519Kolar F P532Kollai M P281Kolsut P P399Komajda M 65Komukai K P109Komuro I P81Komuro I P337Komuro I 59Konorza T P634Korchev Y E P417Korkie L P312Korkus A P460Korte F S P124Kotlikoff M L P76Kotsjuruba A P565Koufaki M P485Kovács M P473

Kozlovskaya A P663Kramer J H P277Kramer J H P313Kramer J H P458Kranias E G 260Kranias E G 83Krause E G P106Krause K H P246Kremastinos D P217Kremastinos D P459Kremastinos D P485Kremneva E P452Krieg T P147Krieg T P500Krieger J E P396Kristek F P621Krobert K A P97Krobert K A P146Krobert K A P671Krum H P350Kucera J P11Kudo Y P337Kudoh S P337Kugimiya T P79Kukoba T P565Kunes J P532Kunishige M P410Kunishige M P421Kuno A P147Kuno A P487Kupai K P490Kupai K P508Kuppusamy P P270Kupriyanov V P315Kupriyanov V P652Kupriyanov V P656Kupriyanov V P169Kupriyanov V P188Kurabayashi M P107Kurabayashi M P214

Kurachi Y P45Kurachi Y P56Kurdi M P138Kurihara S P109Kurisaki A P282Kuroda T P131Kurose H P80Kurose H P113Kurthy M P499Kusama Y P468Kutala V K P270Kuzelova M P552Kuzelova M P553Kuzio B P169Kuzio B P188Kuzmin E P118Kwan J C P220Kwan J C P564Kwan Y P493

LLa Canna G P438La Canna G P439Lab M P417Lacampagne A P299Lacerda L P504Lacerda L P510Lagrasta C P268Lai D P427Lakatta E G P5Lakatta E G 94Lakatta E G 113Lam L P457Lam S S Y P284Lamas Pelaez S 15Lamontagne D P589Lamoureux L P203

Landmesser U 38Landolina M 129Lang U P31Lange R P352Laniado S P254Lantos J P499Lara-Pezzi E P400Larsen A P P49Larsen K O P671Larsen T S P173Larsson H W P655Laszlo A P281Latif N P415Lau C H B P110Lau J M C P235Lazou A P552Lazou A P553Lazzari G P216Le Feuvre C P600Le Prince P P600Lecarpentier Y P294Lecarpentier Y P302Leclerc I P144Lecour S P504Lecour S P510Ledda M P247Lederer W P126Lee C T P153Lee J P67Lee J P134Lee J P272Lee J P415Lee K Y P381Leghissa R P393Legramante J M P279Lehman J P174Lehnart S E 259Lehnart S E 105Lehotsky J P322Lehoux S P600

Leineweber K P77Leineweber K P634Leineweber K 242Lekli I P94Lekli I P575Lekli I P576Lemaire M C P623Lenders M H P326Leoncini E P515Leone L P227Leone T C P174Leong J Y P350Leor J P249Leor J P256Leor J P264Lepicier P P589Lepore M P271Leprán I P15Leprán I P19Leroy J P135Leroy J P351Leshem D P535Lesniak W P211Leung A W C P321Leuwer M P43Levchenko T P587Levi R P288Levitsky D P452Levkau B P613Levy B 45Levy F P146Levy F P414Levy F P97Levy F P671Lewandowski E D P174Lewandowski E D P372LeWinter M M P392Lezoualc'h F P232Li G P263Li H P361

138Li J P369Li J P411Li J P561Li L P359Li Q P156Li Q P494Li R P627Li S P48Li X P48Li X P129Li X P244Li X P339Li Z P81Li Z P339Liang Y P413Liao C P337Liao S P511Liao S P540Licastro F P197Liem D P536Liggett S B P301Lim S P569Lim S P593Lim S S P670Lim S Y P465Lim S Y P525Lin H P484Lin Q P129Lin Q P341Lin S P129Lin S P170Lin S P341Lintz M P405Lintz M P431Lio D P197Liong E C P284Lip G 235Lipskaia L P600Lisi A P247Littwitz C P453

Liu F P411Liu F P607Liu H P369Liu H T P559Liu H T P561Liu J P323Liu J P334Liu J P369Liu W C P561Liu X P170Liu X P316Liu X P607Livadarou E P88Locher M R P293Lochner A P155Lochner A P480Lochner A P489Lochner A P521Lochner A P562Lohse M J P135Lohse M J 68Lompré A P600Lonardo G P17Long C S P363Lookin O N P308Loos B P514Lopaschuk G D P153Lopaschuk G D P180Lopaschuk G D P530Lopaschuk G D 254Lopaschuk G D 57Lopaschuk G D 83Lopaschuk G D 95Lopes J P521Lopez B L P554Lopez B L P627Losano G P303Lotti F P241Louch W E P287Louch W E P391

Lowe H C P529Lu C P611Lu M P179Lu S P236Lu Y P23Lu Y P35Lu Z P64Luboshits G P257Lucas A P232Lucats L P305Luccarelli S P638Luccarelli S P642Lucke S P613Lueder T P335Lueder T P548Lugnier C P136Lugnier C P351Lui R P398Lupu A P248Luther P P334Lutter S P104Lyamina N P P25Lyamina S V P25Lygren B P671Lynch G S P362Lyon A R P55

MMa J P454Ma X P411Ma X L P554Ma X L P627Ma Y T P411Maas O P500MacAllister R J P495Macdonald P S P220Macdonald P S P398

Macdonald P S P564Madhani M P114Maeda M P660Maejima Y P412Maetaka K P161Maggioni A P 49Maggioni A P 142Maggioni A P 188Maggioni A P 190Magli M C P273Magnani B 100Maietta P P645Mak I T P277Mak I T P313Mak I T P458Makary S Y P51Makino N P605Makra P P15Makra P P19Malaguti M P515Malagutti P P255Malfatto G P7Malik G P513Mallet R T P491Maltsev V P5Mancia G 237Mancia G 99Manea A P602Manea A P602Manikandan P P620Manley D P315Manley D P656Mann D P446Mannarino C P332Manoach M P18Mansour M A P550Manukhina E B P25Manukhina E B P491Marbán E 147Marber M 119

Marber M 65Marber M 81Marber M P143Marber M P144Marber M P145Marchase R B P177Marchel M P639Marchel M P641Marino G P304Markakis K P401Markakis K P402Markakis K P544Markakis K P579Marotte F P302Marshall K D P426Marston S P198Marston S P199Marston S P419Marston S P442Marston S P452Marston S P456Marston S P328Martin B P171Martina P P528Martinov V P548Martin-Sanz P P545Maruyama K P137Marzilli M 42Marzilli M 95Marzilli M 116Masaki M P533Maseri A 29Maseri A 34Masri B 4Masri B 51Mastrorilli F P436Matafome P P165Matafome P P166Matafome P P167Matejikova J P24

139Matejikova J P349Matsuo A P410Matsuo A P421Matucci R P83Maugeri S P528Maughan D W P392Maurer F P148Mavroidis M P444May C P630May G L P184Mayama T P12Mayor F P123Mayor F P141Mayr M P116Mazza R P332Mc Lennan P L P10McCarthy J P190McCoy F P355McCoy F P365McCune S A P175McCune S A P426McDermott B P355McDermott B P365McDermott B 59McDermott B P91McDonald K S P124McDuff J P172McElfresh T A P176McElfresh T A P384McFadden E 241McHenry E M P91McHowat J P637McKenna W P456McKinsey T A 134McLatchie L M P59McLatchie L M P150McLatchie L M P333McLennan P L P319McLennan P L P377McMahon A C P529

McMaster B P91McMullen J R P390Mearini G P364Medway D P186Meininger G A P331Melchiorri C P241Mele D P432Mele D P433Mele D P434Mele D 9Mele D 88Mele D 170Mele D 118Melloni E P296Melville A A D P622Menabò R P325Menasché P 213Menazza S P325Meng X P542Meng X P543Meng X P635Meng Y P317Menick D P205Mercadier J P8Mercadier J P385Mercola M 57Mericka P P259Merlini F P255Mersich B P281Messaoudi S P278Messer A P419Messer A P456Messina E P273Métrich M P232Metz-Boutigue M H P332Mialet-Perez J P382Michael G P20Michael I G P493Michaud M P596Miki T P223

Mikros E P459Milanesi O P275Mildaziene V P295Milei J P668Milerova M P519Miller L P42Miller L P249Milliez P P37Milliez P P278Minegishi N P406Ming W T P493Minieri M P181Minieri M P251Miotto G P286Miró E P329Miro-Casas E P297Miro-Casas E P330Mirza M P452Mishali D P256Mitterer G P200Mitterer G P407Miura T P223Miura T P470Miyahara Y P260Miyamoto M P276Miyamoto S P231Miyamoto S P233Mizuno Y P161Mizushima N P338Mjøs O D P481Mladenka P P667Mocanu M M P483Mocanu M M P506Mocanu M M P520Mocanu M M P566Mocanu M M P567Mocanu M M P594Moccetti T P422Moccetti T P653Mochizuki S P18

Mochizuki S 143Modavu I P546Modena M G 39Modena M G 73Modena M G 42Moellmann H P405Moellmann H P431Mohamed T M A P74Mohanlal R 122Mohanlal R 81Mokn W P136Mokry J P259Moldovan H P665Moldovan H P666Molinari C P304Molkentin J D P100Molkentin J D P289Molkentin J D 194Molkentin J D 113Molla B P545Mollica J P P390Moltzau L R P414Monnet X P305Montanari M 263Monteiro P P165Monteiro P P166Monteiro P P167Moolman J A P489Moolman-Smook J C P196Moolman-Smook J C P312Moore P K P469Moore R L P175Moore R L P426Moraitis P P579Morandi L P201Morandi L P393Morano I P104Morano I P340Morawietz H P604Morel E P232

Moreno-Gonzales G P208Morente M P329Morente M P330Mori H P260Morimoto S P109Mork H K P414Mørk H K P97Mørk H K P287Mørk H K P391Morkuniene R P578Morwinski R P98Moscat J P123Moses K P622Moss R L P149Moss R L P293Moss R L P324Moss R L P327Mostacciuolo G P375Mourouzis I P88Mourouzis I P401Mourouzis I P402Mourouzis I P477Mourouzis I P544Mourouzis I P579Moybenko O P565Moybenko O P669Mraiche F P380Mudalagiri N R P520Mueller R A P224Mueller R A P577Mugelli A P17Mugelli A P29Mugelli A P36Mugelli A P83Mugelli A P245Mugelli A P250Mugelli A P418Mugelli A P629Mugelli A P658Mugelli A 247

140Mugelli A 47Mugelli A 118Mügge A P453Mujkosova J P168Müller G P604Mummery C P420Munir M S P427Munir M S P428Munzel T P252Murakami H P443Murakami S P45Murakami S P56Murali Manohar B P582Murali Manohar B P620Murdoch C E P389Murdoch C E P603Murga C P141Murohara T P443Murphy E P467Murphy E 212Muscari C P238Muscari C P241Muscari C 79Muslin A J P234Muslin A J P235Musso E P268Mustafa S J P550Musters R P516Muthuchamy M P331Mwamure P K P495Mykytenko J P503

NNachtigal P P667Nagasaka Y P408Nagaya N P260Nagler A P264

Naguro I P102Naitoh K P470Najafi M P28Najafi M P34Naka T P84Naka T P132Nakagawa Y P410Nakagawa Y P421Nakai A P338Nakazawa M P408Napier C P318Narayanan N P112Nardi A P47Nardo B P267Naruse H P356Nassi P P556Nataatmadja M P636Nauciene Z P295Nauerth A P650Naumann S P352Nawratek R P77Nazemiyeh H P34Neckar J P24Neckar J P516Neckar J P519Nederhoff M G J P650Nediani C P418Nediani C P556Nef H P405Nef H P431Nemir M P367Nesi M P83Netser S P264Neubauer S P186Neubauer S P192Neumann J P89Nevelsteen I P388Newby D E 234Newby D E 99Newman G P511

Newman G P540Neyses L P74Neyses L P374Neyses L 43Neyses L 56Ng K P350Nguyen C P146Nicolaou S P100Nicolosi G P438Nicolosi G P439Nicolosi G P440Nicolosi G 101Niebisz A P157Niebisz A P158Niebisz A P348Nikolaev V O P135Ning X P90Ning Y P611Nishibe A P410Nishibe A P421Nishida M P80Nishida M P113Nishihara M P470Nishimura Y P309Nishimura Y P660Niwano H P32Niwano H P463Niwano H P464Niwano K P214Niwano S P32Niwano S P463Niwano S P464Noble D 221Noble D 226Noble D 97Nomair F R P550Norfleet E P224Norfleet E P577Norton G P155Notarstefano P P61

Notarstefano P P62Notarstefano P P63Notarstefano P P433Novak F P516Novak F P519Novakova O P516Novakova O P519Nygård S P416

OO’Brien J D P466O’Rourke B 193O’Rourke B 107Oberlin A P311Oberlin A P314Oberlin A P193O'Brien T X P205Obukhov A G P44Oceandy D P74Oceandy D P374Ochi M P557Ochi M P558Ochi M P574O'Donnell J M P372Ogawa C P187Ogawa K P12Ogay S P271Ohba T P598Ohori K P223Ohori K P470Ohta Y P408Ohyanagi M P84Ohyanagi M P121Ohyanagi M P132Oie E P335Øie E P416Okada M P356

Okada T P79Okada T P282Okamura Y P309Okamura Y P660Okruhlicova L P22Okruhlicova L P33Okruhlicova L P86Okruhlicova L P98Okruhlicova L P621Okumura K P443Olesen S P P47Olesen S P P49Olivares A P614Oliveira E M P360Oliveira E M P396Oliviero P P294Oliviero P P302Olson E 105Oltenau C P405Oltenau C P431Olthof M 140Olthof M 87Onay-Besikci A P177Onohara N P113Opie L 111Opie L 144Opie L 57Opie L 102Opie L 109Opie L P190Opie L P480Opie L P504Opie L P510Opolski G P639Opolski G P641Ordener C P382Orlova E P191Orosz S P9Orosz S P15O'Rourke B P474

141O'Rourke S P625O'Rourke S P601O'Rourke S P632Orrico C P238Osaka T P306O'Shea K M P176O'Shea K M P384Osnes J P414Osnes J B P97Osnes J B P146Ostadal B P532Ostadal B 80Ostadal B 93Ostadal B 118Ostadalova I P532Oto A 175Oto A 35Oto A 50Otsu K P338Otsu K P409Ottani Cavina A 106Ottolenghi S P273Ovize M P269Ovize M P496Ovize M 196Ovize M 205Ovize M 110

PPacileo G P198Pacileo M P645Pacileo M P646Padalino M P275Padeletti L 169Padeletti L 44Padron R P334Pagliari F P251

Pagliari S P251Pagliaro P P303Pagnotta E P515Paillard M P496Paiva M P165Paiva M P166Paiva M P167Paiva M P566Paizis I P579Paju K P191Palaniyappan A P581Pallante M P279Palmer B M P392Pampu G P665Pampu G P666Pan C P130Panagiotou M P401Panagiotou M P402Panagiotou M P544Panagopoulou P P446Pang W P244Pantos C P88Pantos C P401Pantos C P402Pantos C P477Pantos C P544Pantos C P579Paoletti R 63Paolocci N P195Paolocci N P298Papaefthimiou M P459Papp J P9Papp J P46Papp R P473Pappone C 91Paramanathan A J P593Parchomenko O P669Parini A P382Parker J P484Parker T G P211

Parker T G P219Parrinello G P436Parrinello G P438Parrinello G P440Parrinello G P619Parrinello G P647Pasotti E P422Pasotti E P653Pasquinelli G P238Pasquinelli G P267Pasterkamp G P649Pastorekova S P168Patel N G P67Patel R P378Patel R P379Patsouris E P217Pavljuchenko V P669Pavlova S P657Pavlovic D P333Peart J N P512Peart J N P523Pechanova O P168Pechanova O P342Pechanova O P343Peco Navio R P192Pedrazzini G P422Pedrazzini G P653Pedrazzini T P10Pedrazzini T P271Pedrazzini T P367Peitl B P154Peitl B P502Pelá G 118Pellegrino D P68Pellegrino L P255Penzo C P255Peoples G E P377Pepe S P10Pepe S P319Pepe S 200

Pepe S 37Pepe S 60Pepe S 95Pepe S 114Pepine C 64Percoco G F P644Percoco G F P648Percoco G F 38Peregrin S P141Pérez R P668Periasamy M P16Perimenis P P88Perin E C P258Perkins K P164Perriello G 152Perrino C P221Pession A P201Pession A P201Pession A P393Pession A P393Peters N S P55Petitprez S P11Petretta M P404Petrillo G P646Petrini S P198Petzhold D P104Pezet M P8Philipson K D P290Phillips A R J P461Piegari E P202Piegari E P227Piepoli M F P429Piepoli M F P430Pierce G N 164Pierce G N 82Pieske B P142Pieske B P551Pikkarainen S P228Pineau T P302Ping P P339

Ping P P536Ping P 86Pinter A P281Pinto A P344Pipis J P479Pirk J P532Pisarenko O P183Pisulewski P P609Pizzinat N P382Podesser B P549Podesser B P200Podesser B P407Pohlmann L P659Poindexter B J P662Poitz D M P206Pollesello P P480Pons S P590Pontremoli S P296Poole-Wilson P 168Poole-Wilson P 187Poole-Wilson P 88Poole-Wilson P P55Popescu B A P665Porat E P460Porat E P535Porat E P595Porcellini E P197Porchetta I P262Porfirio A P198Porrello E R P362Port J D 243Porter D P511Portman M A P90Post H P142Post H P551Postula M P157Postula M P158Postula M P348Postula M P639Postula M P640

142Postula M P641Postula M P643Potolitsyna N P663Pott L P453Potter K T P194Poulin G P428Powers A S P403Powers P P149Prabhu S P541Prairie N P361Prati F 240Praticò D 252Praticò D 115Pratola C 49Pratola C 92Pratola C P61Pratola C P62Pratola C P63Pratola C P433Pratola C P434Prehar S P374Preveolos P216Prociuk M A P204Prolla T A 197Prolla T A 74Pronayova N P654Prough R P541Providencia L P165Providencia L P166Providencia L P167Providência L P566Prunier F P357Pruss R P596Pruvot E P11Prysyazhna O D P162Psarras S P444Pudil R P259Pudil R P425Pulerà E P303Purali N P299

Puskas L P46Puvanakrishnan R P582Puvanakrishnan R P620Puzserova A P345Puzserova A P346Puzserova A P347Pyle W G P119Pyle W G P120

QQi Y P130Qin Q P536Qin Y P81Qu A P226Quaini F P268Quaini F 78Quinlan C L P128Quintieri A M P303Qvigstad E P97Qvigstad E P146Qvigstad E P414

RRaanani E P256Rackley M P205Rácz B P499Raddatz E P40Raddatz E P148Rademaker M T P96Radicke S P30Rahman M P632Raicu M P602Raimondi G P279Raimondi L P83

Raimondi L P629Raimondi L P658Rajamani S P52Ramaekers F C S P326Ramasamy S N P215Ramella R P288Rapacciuolo A P368Rapezzi C 48Rapezzi C 64Rapezzi C 192Rapezzi C 103Rapezzi C 104Rapti K P445Rassaf T P531Rastaldo R P303Rathinavel A P215Rattan S P204Rattan S G P140Rattan S G P336Ravara B P423Ravara B P424Ravens U P27Ravens U P30Ravens U P57Ravens U P604Ravens U 99Ravingerova T P24Ravingerova T P349Ravingerova T P552Ravingerova T P553Ray R P603Razumova M V P293Reaburn P P164Redwood C P312Redwood C P442Redwood C P452Rees M L P175Rees M L P426Reeves J G P503Reis S P453

Remme W 248Remme W 64Remme W 68Remme W 111Remme W P439Remme W P440Remme W P619Remme W P647Remuzzi G 236Renaud J F P101Revel Chion R P434Revel Chion R P432Revel Chion R P433Revera M P196Reyes-Juarez J L P209Reynolds L P625Reynolds L P P601Ribas C P123Ribuot C P517Richards A M P21Richards A M P96Richter H P147Richter W P135Riise J P146Riley P R P622Risebro C A P622Risøe C 7Ritchie R H P378Ritchie R H P379Ritchie R H 54Rizos I P217Robbins J 229Robinson P P452Robinson R B P39Rocchetti M P242Rocchetti M P375Rochette L P527Rochette L P599Rodgers R L P178Rodolico G P202

Rodolico G P227Rodriguez G P208Rodriguez G P210Rodríguez G P209Rodriguez-Granillo G A 238Rodriguez-Sinovas A P330Rodríguez-Sinovas A P329Rogers T P126Rokkas C P217Rolin S P92Romano P251Romero-Vecchione E P344Roos K P P290Rosa F P344Rosa K T P360Rosano G 5Rosano G 64Rosca A M P253Rose'Meyer R B P93Rosen M 29Rosen M 126Rosen M 35Rosen M 47Rosen M 103Rosenbaum D S 21Rosenblatt-velin N P271Rosenfeldt F L P350Rosenthal N P400Rosenzweig A 211Rosenzweig A 117Ross J L P538Rosse M P6Rossi F P202Rossi F P227Roszczynko M P399Roth E P499Rouet P P8

143Rouet-Benzineb P P385Routkevitch S P308Rozanski G J P48Rubio M P100Ruchon Y P101Rücker-Martin C P357Rudas L P15Rudas L P19Ruigrok T J C 28Ruigrok T J C 111Ruiz-Meana M P297Ruiz-Meana M P329Ruiz-Meana M P330Ruskoaho H P386Russel B P370Rutkovsy A P475Rutter G A P144Rütz P500Ruzicska E P386Ruzyllo W P399Rybakova I N P327Ryou M P491

SSabbah H P387Sacco S P279Sack M N P190Sagach V P162Sagar S P193Sagar S P311Sagar S P314Sagie A P460Sagie A P595Sahinoglu B P299Saidel G P179Sakai T P410Sakai T P421

Sakamoto K P661Sakoda T P84Sakoda T P121Sakoda T P132Sakurai M P282Salamino F P296Salie R P489Salle L P3Salpeas V P217Salvetti A 64Samantapudi D P435Sampaolesi M P242Samuel J P37Samuel J L P278Samuel J L P351Sandirasegarane L P230Sandnes D P146Sano M P187Sanoudou D P444Santiago J P336Santiago J P353Santonastasi M P54Santorelli F P198Santulli G P580Santulli G P606Sanzen Y P408Sanz-Moreno V P141Sariahmetoglu M P462Sarre A P40Sarre A P148Sartiani L P245Sartiani L P246Sartiani L P250Sasaki H P109Sasaki S P463Sasaki S P464Sasso L P646Sato H P408Sato T P282Sato Y P80

Satoh D P32Satoh T P470Savi M P268Sawamura T 123Scanlan T S P108Schaar J 239Schaller S P596Scheinowitz M P182Scheinowitz M P254Scheinowitz M P257Schertzer J D P362Schiaffino S P274Schiaffonati L P358Schlapfer J P11Schlossarek S P364Schlossarek S P455Schmeisser A P206Schmidt A P551Schmidt W P200Schmidt W P407Schmitto J P551Schneider M 58Schneider M 78Scholz D P371Schreiber C P352Schroth G 61Schuchardt M P613Schuchert A 90Schultheiss M P252Schultz G P551Schultz J P511Schultz J E J P540Schulz R P77Schulz R P307Schulz R P320Schulz R P441Schulz R P462Schulz R P497Schulz R P505Schulz R P624

Schulz R 22Schulz R 120Schulz R 81Schulze W P86Schulze W P98Schwartz A P100Schwartz A P301Schwartz K P364Schwartz P J 30Schwartz P J 233Schwartz R J P622Scott M A P450Scott M A P451Scowen P P42Sears C E P111Sebag-Montefiore L P186Sebag-Montefiore L P192Seica R P165Seica R P166Seica R P167Seidman C E P457Seidman J G P457Sejersted O M P287Sejersted O M P289Sejersted O M P391Seki S P18Selvam G S P215Semecky V P667Semsarian C P457Semus H M P87Senbonmatsu T P137Senbonmatsu T 156Senyo S E P370Seo J S P591Seppet E P191Seprenyi G P46Seprényi G P473Serafin A P639Serafin A P640Serafin A P641

Serafin A P643Serban M P665Serban M P666Serebryakova L P183Setacci C 62Severs N J 18Severs N J 31Severs N J 36Sewry C P198Seymen A P300Seymen A P626Seymour A M L P381Seymour A M L P383Seymour A M L P151Seymour A M L P160Seymour A M L P185Seymour A M L 57Shah A 11Shah A P389Shah A P603Shah A P397Shainberg A P460Shainberg A P535Shainberg A P595Shan Z P129Shan Z P341Shankar K J P427Shankar K J P428Sharma A K P229Sharma N P387Sharov V P387Shattock M 28Shattock M 48Shattock M 146Shattock M P59Shattock M P72Shattock M P150Shattock M P333Sheeran F P319Sheich Yosef B P256

144Shen E P447Shen L P285Sheng S P474Shiels H A P292Shimamoto K P223Shimamoto K P470Shimizu K P557Shimizu K P558Shimizu K P574Shimizu N P187Shimokawa H P406Shinagawa H P306Shlyakhto E V P631Shlyakhto E V P633Shryock J C P52Shulz R P330Shysh A P565Siddall H K P567Siedlecka U P67Siedlecka U P134Siedlecka U P272Siedlecka U P415Sikurova L P171Silva G V P258Simionescu M P253Simionescu M P602Simoons M 117Simoons M 42Simoons M P619Simoons M P647Simpkin J C P525Simpkin J C P569Singal P K P229Singal P K 30Sinoway L I P230Sipido K 174Sipido K P103Sipido K P672Sirtori C 67Sisakyan H 88

Sitnikova M P631Sitnikova M P633Siva A P389Sivonova M P322Sjaastad I P97Sjaastad I P287Sjaastad I P289Sjaastad I P391Sjaastad I P414Sjaastad I P671Skalak T C 103Skaltsounis L P459Skarra S P547Skjold A P655Skjønsberg O H P671Skomedal T P97Skomedal T P146Skomedal T P414Skorka T P609Skrle J P667Skyschally A P307Skyschally A P505Sliwa K P71Smart N P622Smeets P J H P354Smiseth O 8Smiseth O 45Smiseth O P335Smith C C T P525Smith C C T P568Smith C C T P569Smith K P381Smith R M P514Smith W P155Smolic A P216Snabaitis A K P115Snabaitis A K P127Sofronescu A G P212Sollott S J 199Sollott S J 108

Somers S P510Song Y P635Sonne D P P498Sonoda S P79Sood S P54Soppa G P272Soppa G P67Soppa G P134Soppa G P415Sorgente A P422Sorgente A P653Sorriento D P606Souktani R P596Spagnuolo R P645Spallarossa P 13Spanou D P88Sparagna G C P175Sparagna G C P426Spinelli L P580Squasi P P648Srivastava D 180Srivastava S P488Stables C P14Stagg M P272Stagg M P67Stagg M P134Stagg M P415Stanley W C P179Stanley W C P387Stanley W C P176Stanley W C P376Stanley W C P384Stanley W C 208Stanley W C 112Steenbergen C P467Steenbergen C 51Steg P G P437Stein C M 245Steinberg S F 87Steinberg S F 53

Steinberg S F 66Stella A 219Stellin G P275Stelzer J E P149Stelzer J E P293Stenslokken K O P475Stienen G J M P125Stifanese R P296Stillitano F P17Stillitano F P245Stillitano F P250Strasser R H P206Strasser R H P610Strauer B E 215Strauss M P344Stuckey D J P240Studneva I P183Stupin I V P427Stupin I V P428Sturek M P44Su H P560Su X P543Su X P635Subramaniam S P582Suda R P80Suffredini S P29Suffredini S P36Suffredini S P60Suffredini S P250Sugano M P605Sugden P H P228Sugden P H 43Sugden P H 54Suleiman M S P484Suleiman M S P522Suleman N P510Sultan K P659Sultan K P455Sumitra M P620Sun F P526

Sun J P467Sun J P652Sun J 178Sun S P607Sun X P560Sun Y P218Sun Y P403Sun Z P331Sunkomat J P265Suzuki S P45Suzuki S P56Suzuki T P392Svec P P552Svec P P553Sykes J P635Szabo G P94Szabo G P571Szabo G P575Szarszoi O P532Szebeni A P13Szilvássy Z P154Szilvássy Z P502Szperl M P399Szucs G P508Szuts V P46

TTabib A P38Tabilio A P262Taddei S 36Taegtmeyer H 256Taegtmeyer H 58Taegtmeyer H 63Takagi G P276Takagi I P276Takahari Y P651Takahashi R P443

145Takahashi Y P598Takano H P276Takano H P468Takano T P276Takayama M P468Takeda M P406Takehana H P306Takeshita A 24Tamareille S P357Tamargo J 101Tamargo J 115Tamimi T R P585Tan W P494Tanaka H P187Tang C P130Tang D P285Tang K P48Tang X P488Tanno M P223Tanriverdi E P300Tanriverdi E P624Tanriverdi E P626Tao L P554Tao L P627Tappia P S P75Tappia P S P237Tappia P S P361Tara S P276Tarchalska B P157Tarchalska B P158Tarchalska B P348Tarchalska B P639Tarchalska B P640Tarchalska B P641Tarchalska B P643Tardif J C 35Tardif J C 116Tardif J C 173Tasken K P671Tatarkova Z P322

Tatton L P240Taunton J P127Tavazzi L P438Tavazzi L P439Tavazzi L P440Tavazzi L 191Tavazzi L 32Taylor E W P292Taylor K P334Te Boekhorst B C M P649Te Boekhorst B C M P650Tellez J O P41Tellez J O P51Ten Hove M P186Ten Hove M P192Tendera M P437Tendera M 67Teodori G P304Terracciano C 54Terracciano C P67Terracciano C P134Terracciano C P272Terracciano C P415Terzic A P311Tesseromatis C P401Testoni S P108Thai H P266Theiss M L P10Theiss M L P319Thiene G P243Thiene G P275Thomas C J P283Thomas C J P630Thomas W G P362Thompson I P531Thuillez C 101Thum T P252Thum T P420Tian G P263Tichy M P425

Tiengo A 71Timour Q P38Tipoe G L P284Tiravanti E A P472Tissier C P6Tissier C P527Tissier C P599Tissier R P590Titorencu I P253Tjong Y W P284Tocchetti C P298Toffoli S P275Toker A 132Toker A 85Tokudome S P187Tölle M P613Tomanek B P263Tomanek R J P563Tomaselli G F P397Tona F P243Tong C W P149Torchilin V P587Torre I P330Tosaki A P94Tosaki A P570Tosaki A P571Tosaki A P575Tosaki A P576Toselli T P61Toselli T P62Toselli T P63Toselli T P432Toselli T P433Toselli T P434Toselli T 66Tota B P303Tota B P332Toth M P386Totzeck M P531Traber D P662

Treiman M P498Trescher K P200Trescher K P407Trescher K P549Tribulova N P18Tribulova N P22Tribulova N P33Tribulova N P621Trimarco B P580Trimarco B P606Tritto I P262Troidl C P405Troidl C P431Trzeciakowski J P P331Tsang S P73Tsang V P456Tsinarakis N P477Tsivian M P267Tskitishvili O P183Tsoporis J N P211Tsoporis J N P219Tsotinis A P485Tsoutsman T P457Tsujimae K P45Tsuru H P102Tu E P457Tubaro M 6Tubaro M 43Tubaro M 100Tuncay E P299Tuncay E P300Tuncay E P626Tune J D P44Tünnemann G P340Tunstall R P625Tunstall R P632Tuomilehto J 149Tuomilehto J 155Turan B P70Turan B P299

Turan B P300Turan B P441Turan B P462Turan B P624Turan B P626Turan B 59Turner A P652Tyagi S C 23Tyler D J P240Tzeis S P579

UUcci G P646Ugur M P70Ugur-Altun B P95Usprech J P119Ussher J E R P153Ussher J E R P530Uwiera R R E P82Uwiera R R E P581

VVaage J P475Vaillant F P38Valdivia H P298Valen G P548Valgimigli M P255Valgimigli M P642Valgimigli M P644Valgimigli M 84Valgimigli M 138Van Beek-Harmsen B J P395Van Bilsen M P354

146Van Caster P P307Van Caster P P505Van de kolk K W A P650Van de Sand A P77Van den Bergh A P69Van den Bergh A P388Van den Bergh A P492Van der Giet M P613Van der Laarse W J P395Van der Mieren G P448Van der Mieren G P492Van der Velden J P125Van der Vusse G P354Van dijk J P152Van Echteld C 72Van Echteld C P649Van Echteld C P650Van Eyk J E P397Van Eyk J E P435Van Eyk J E P474Van Laake L P420Van Lint J 131Van Oosterhout M F M P649Van Rooyen J P562Van Wezel H P152Van Buren P P392Vandecasteele G P135Vandecasteele G P136Vandecasteele G P351Vanderper A P69Vandroux D P6Vandroux D P527Vandroux D P599Vangheluwe P P69Vardas P E 41Vardas P E 50Varga E P576Varga-Orvos Z P46Varró A P46Varró A P9

Varró A P15Varró A P19Vasile S P665Vasile S P666Vásquez J P344Vassort G P104Vassort G P299Vassura G P241Vázquez J P329Vecsernyes M P570Vecsernyes M P571Végh Á P26Végh Á P50Végh Á P473Veksler V P189Vela D P258Venardos K P537Venerando R P286Ventura C 135Ventura C 38Ventura C 77Ventura-Clapier R P189Verheyen F K P326Verma D D P587Verma S 157Verma S 71Vernet M P364Vescovo G P423Vescovo G P424Vescovo G 80Vidne B P460Vidne B P535Vidne B P595Vignier N P294Vignier N P364Vignier N P455Vila Petroff M G 95Vila Petroff M G 44Vila Petroff M G 53Vila Petroff M G 112

Villareal F J 25Villareal F J 31Vincze D P19Vinet L P8Vinet L P385Vinten-Johansen J P503Violi F 79Virag L P46Viragh E P13Virdee I P112Visioli F 139Visioli F 87Visioli O 42Viswalingam K P313Vitelli M R P202Vitelli M R P227Vladimirov Y P657Vlasuk G P P87Voisin S P599Vojacek J P259Vojacek J P425Vokurkova D P259Volpe M 110Von Lewinski D P142Von Wnuck Lipinski K P613Vonnahme K P625Vos M 225Voss S P405Voss S P431Vural V A P597

WWachtell K 66Waczulikova I P168Waczulikova I P171Waguri S P661Waintraub X P590

Wakisaka Y P463Waldmann-Beushausen R P551Walker J W P85Walker J W P323Wallis J P186Wallukat G P71Wallukat G P86Wallukat G P98Walsh K 104Wan W P403Wang B P140Wang C P359Wang G X P42Wang H P224Wang H P577Wang H C P559Wang H C P560Wang H C P561Wang L P263Wang R P218Wang S P530Wang S P630Wang T P592Wang W P530Wang W 179Wang X P130Wang X P213Wang X P226Wang Y P126Wang Y P289Wang Y 65Ward M L P291Ward M L P461Watanabe A P107Watanabe A P214Watanabe H P598Watanabe M P79Watanabe M P282Watanabe T P409

Watkins H P312Watts G F P350Webster K 124Wee S P93Wee S P512Weglicki W B P277Weglicki W B P313Weglicki W B P458Wehrens X H P54Weiss R M P563Welch W P413Wells D P442Wendt I R P378Wendt I R P379Wenzel P P252West M P636Wettwer E P27Wettwer E P30White M Y P474Widdop R E 93Wieland T 203Wijns W 29Wijns W 45Willems L P537Willemsen P H P354Willerson J T P258Willerson J T 216Willerson J T 67Willert M P610Willette R 121Willette R 86Williams A G P491Williams I 68Williams I P449Wilson B P403Wilson G P118Winkler H P334Wiseth R P547Wöhrl S P57Wojnar L P609

147Wolff G P340Wolner E P549Wong D P118Wong S S C P73Wong T M P73Wong T M P105Wood P P120Woodcock E 43Woodcock E 51Woodiwiss A P155Woodman O P630Woods R L P283Woskoboinic J P668Wright J P239Wu F S P561Wu G P285Wu H P454Wu J P282Wu L P359Wu M P672Wu S P73Wu W P170Wu W P494Wu X P331Wu X P607Wuytack F P69Wynne A P483Wynne A P506Wynne A P569Wynne A P471

XXi J P224Xi J P577Xiang B P263Xiang B P656Xiang Y P411

Xiao R 209Xiao R 113Xiao R P P394Xinaris C P88Xinaris C P401Xinaris C P402Xinaris C P544Xinaris C P579Xiong D P42Xiong S P612Xu A P112Xu C P218Xu C P611Xu J P369Xu J P664Xu L P369Xu L P611Xu M P64Xu M P226Xu X P372Xu X P518Xu Z P48Xu Z P224Xu Z P577Xue J P373

YYacoub M H P272Yacoub M H P67Yacoub M H P134Yacoub M H P400Yacoub M H P415Yamaguchi O P338Yamamoto E P468Yamamoto T P408Yamashita S P608Yamauchi-Takihara K P131

Yamauchi-Takihara K P533Yamawaki H P356Yamboliev I A P42Yang B P23Yang B P35Yang B P316Yang B P317Yang D P454Yang D P518Yang D P664Yang H P65Yang J P524Yang L P417Yang X P509Yang X P543Yang X P656Yang Y P315Yang Y P447Yang Y P612Yang Y P652Yang Y P656Yang Y N P411Yanni Gerges J F P41Yano T P223Yano T P470Yaras N P299Yaras N P300Yaras N P441Yasuda N P81Yasutake M P276Yasutake M P468Yeh E 78Yellon D M 195Yellon D M 111Yellon D M P465Yellon D M P483Yellon D M P495Yellon D M P506Yellon D M P520Yellon D M P525

Yellon D M P566Yellon D M P567Yellon D M P568Yellon D M P569Yellon D M P593Yellon D M P594Yin L P611Yin X P116Yitzhaki S P595Yndestad A P416Yokoya S P661Yoshida Y P408Yoshikawa A P137Yoshikawa N P187Yoshimasu T P309Young G P339Young G P536Young M E P180Yousufuddin M P314Ytrehus K P481Ytrehus K P501Yu C P526Yu C P588Yu X P129Yu X P170Yu X P179Yu X P341Yu X P526Yu X P588Yu X P592Yuan Y X P554Yung C P435Yusuf S 109Yusuf S 184

ZZaglia T P274

Zanchetti A 112Zannad F 76Zannad F 73Zannad F 84Zarain-Herzberg A P208Zarain-Herzberg A P209Zarain-Herzberg A P210Zaremba R P125Zarrinpashneh E P144Zatta A P503Zaza A P7Zaza A P242Zaza A P375Zaza A 172Zaza A 227Zaza A 97Zaza A 99Zeman M P345Zernicka-Goetz M 56Zernicka-Goetz M 77Zeydanli E P624Zeydanli E P626Zhang C P323Zhang G P213Zhang H P3Zhang H P139Zhang H P156Zhang H P627Zhang J P316Zhang J P454Zhang J P518Zhang J P524Zhang J P664Zhang J F P411Zhang J Q P403Zhang K P156Zhang L P461Zhang L P592Zhang M P111Zhang M P389

148Zhang Q J P156Zhang T P573Zhang W P218Zhang X P317Zhang Y P64Zhang Y P139Zhang Y P417Zhang Y H P111Zhao C P317Zhao F P611Zhao J P130Zhao M P573Zhao X P316Zhao X P317Zhao Y P230Zhao Y P355Zhao Y P365Zhao Y P369Zhao Y Y P91Zhao Z P503Zheng D P285Zheng W P563Zhilkin P A P188Zhong J P129Zhong Q P119Zhu M P526Zhu M P588Zhu M P592Zhu S P454Zhu W P394Zhu X P494Zhu Y P244Zi M P374Ziegelhoeffer A P168Ziegelhoeffer A P171Zini R P590Zira A P459Zoga A P485Zong C P339Zong C P536

Zorov D 52Zou N P542Zou N P543Zsuga J P94Zucchi R P60Zucchi R P108Zuchi C P262Zummo G P332Zuurbier C J P152Zuurbier C J P476

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XIX WORLD CONGRESS OF THE ISHR - iec-srl.it · the XIX World Congress of the ISHR will transmit a ... globalization it is still important to be part of a ... Carpigiani, Culligan,