Protocol: BVD-CNV2

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Protocol number: BVD-CNV2. Document title: Phase 1 safety study of intratumoral injection of

Clostridium novyi-NT spores in patients with treatment-refractory solid tumor malignancies.

Version number: SAP Version 2. Date of the document: 17 March 2017. NCT number: NCT01924689

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International’s electronic signature policies and procedures and in compliance with applicable regulations.

UserName: Title: Date: Saturday, 18 March 2017, 01:32 AM GMT Standard Time Meaning: Document contents authored. ================================================

UserName: Title: Date: Saturday, 18 March 2017, 01:32 AM GMT Standard Time Meaning: Document contents approved. ================================================

Document ID: 347065665 - Name at Publication: biomed valley bvd-cnv2 SAP Version 2.0.docxThis document contains a total of 36 pages including any signature page/s.

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