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WP1 Progress report Vienna, 13 March 2011. Achievements General. 4 Staff members (1 Image Analyst, 1 part-time Radiologist, 2 Research Assistants) in place Obtained approval from Medicines and Healthcare products Regulatory Agency - PowerPoint PPT Presentation
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WP1 Progress report
Vienna, 13 March 2011
AchievementsGeneral
- 4 Staff members (1 Image Analyst, 1 part-time Radiologist, 2 Research Assistants) in place
- Obtained approval from Medicines and Healthcare products Regulatory Agency
- Local Ethical Approval obtained provisionally, pending clarifications
AchievementsStructural Imaging
1 Site survey ✔2 Site selection ✔3 Radiological and structural protocols (ADNI-GO) for 3T
scanners finalised and Manual sent to sites ✔4 Image Management System (TrialTracker) and electronic
data transfer tool (TrialWire) ✔
1 Sites to upload protocol and return protocol form in progress2 Sites to scan phantom and send details to IXICO in progress3 Sites to scan 1 healthy volunteer and send details to IXICO
not startedQualification and start scanning
AchievementsStructural Imaging
3T SITESurvey
SentSurvey
ReceivedProtocol
SentProtocol Received
ACR Phantom at Site
ACR Phantom Scan Requested
ACR Phantom Scan Received
London Y Y Y Y Y Y YPrague Y Y Y Y Y Y YLeuven Y Y Y Y Y Y YUtrecht Y Y Y Y Y Y NMelbourne Y Y Y Y Y Y NCopenhagen Y Y Y Y Y Y NTel Aviv Y Y Y Y Y Y NMadrid Y Y Y Y N N NNaples Y Y Y N N N NBucharest Y Y Y N N N N
Innsbruck considering to join WP1
AchievementsMagnetic Resonance Spectroscopy1 London, Copenhagen, Utrecht have met and agreed
protocol2 Spectra (anterior cingulate and thalamus) from
Copenhagen and Utrecht can be read and give reasonable values
3 The data can provide metabolite ratios4 Currently exploring whether we can do correction for
CSF in the MRS voxel which is a superior approach to the ratio method
Milestones 1 Completion of preparation work for MRI sites
2 Start scanning
Deliverables1 Qualification of sites, test of electronic data transfer tool
2 Estimate of numbers (200 in total: if 10 sites, 20 patients per site)
Possible concerns
Combination of MRS data:
- Existing power calculation did not take into account the greater variability of multicentre design
- Increase number of subjects with MRS at each site (~30-40 each: existing plan is for 20 subjects scanned twice in London and Copenhagen, so it would be slightly more than double)
- If datasets cannot be combined, we could explore whether findings are reproduced across sites
Planned progress- Obtain final approval from local ethics- Qualify sites- Start recruitment and scanning- All sites to continue to scan phantom regularly plus 2
healthy volunteers (from the site) yearly, preferably every 6 months and before and after upgrades