2002 steroids

steroidsU 0300

46 - 189Withanolide Derivatives from the Roots of Withania somnifera andTheir Neurite Outgrowth Activities. — Five new constituents, cf. (I)and (II), along with fourteen known compounds are isolated from the methanolicextract of the title plant. The structures of the new compounds are determinedon the basis of spectroscopic and physicochemical evidence. Epoxy compound(I) and five of the known compounds show significant neurite outgrowth activityin the one-digit micromolar range using a human neuroblastoma SH-SY5Ycell line. — (ZHAO, JING; NAKAMURA, NORIO; HATTORI, MASAO;KUBOYAMA, TOMOHARU; TOHDA, CHIHIRO; KOMATSU, KATSUKO;Chem. Pharm. Bull. 50 (2002) 6, 760-765; Dep. Metab. Eng., Toyama Med.Pharm. Univ., Toyama 930-01, Japan; EN)

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