William Harvey Day 2013

William Harvey DayProgrammeWednesday�16�October�2013St�Bartholomew’s�Hospital,�West�Smithfield,�London

This�year's�William�Harvey�Day�willshowcase�cutting�edge�researchundertaken�in�Barts�and�the�LondonSchool�of�Medicine�and�Dentistry.Through�the�day�we�will�hear�ninepresentations�by�researchers�at�variousstages�of�their�research�careers,�togetherwith�three��“hot�topic”�presentations�frominvestigators�who�have�recently�joinedQueen�Mary,�as�early�career�fellows.�I�ampersonally�most�grateful�to�our�threedistinguished�guest�speakers�who�willprovide�the�named�Lectures.��Finally,�I

want�to�draw�your�attention�to�the�over�230�posters�on�display�duringthe�event.�These�will�provide�a�fantastic�overview�of�the�breadth�ofwork�underway�across�the�School�and�posters�will�be�found�in�theGreat�Hall�and�the�Pathology�Museum.

We�are�delighted�that�the�main�lectures�will�be�given�by�ClareMatterson�from�the�Wellcome�Trust,�Professor�Jack�Cuzick�from�theWolfson�Institute�and�Professor�Sir�Peng�Khaw,�from�the�Institute�ofOphthalmology,�UCL�and�Moorfields�Hospital.

The�day�will�conclude�with�the�Barts�and�The�London�NHS�Trust’straditional�annual�St�Luke’s-tide�Service�in�the�church�of�StBartholomew�the�Great�at�6.00pm.�I�would�be�delighted�if�you�wereable�to�attend�the�Service,�as�this�is�a�traditional�and�very�enjoyablepart�of�the�day.

Professor Richard TrembathVice Principal and Executive Dean (Health)

Welcome to WilliamHarvey Day

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11:35Oral presentations

“Is�cascade�testing�an�effectivemethod�of�screening�for�familialhypercholesterolemia?”

Professor Joan Morris Wolfson�Institute�of�Preventive�Medicine�

“Identification�of�ZDHHC14�asa�novel�tumour�suppressorgene�commonly�downregulatedin�human�cancers”

Dr Marc Yeste-Velasco Centre�for�Molecular�Oncology,Barts�Cancer�Institute

“iASPP�is�a�key�inhibitor�ofautophagy�in�keratinocytes”

Dr Anissa ChikhCentre�for�CutaneousResearch,�Blizard�Institute

12:20Year 2 Medical Student Research Project Prizewinner

“Breast�Cancer�and�Pregnancy”

Laura Van Der Krogt

12:30Schorstein Lecture

“What's�my�chances,�doc?�Quantifying�andcommunicating�acute�and�chronic�risk”

Professor David Spiegelhalter FRSWinton�Professor�of�the�Public�Understanding�of�Risk,�Statistics�Laboratory,University�ofCambridge�

Introduced�byProfessor�JackCuzick.

13:15-14:30

Lunch�andposter�viewing�(Great�Hall�andPathologyMuseum)

Please�refer�tothe�front�of�thisprogrammewhich�indicates

which�venue�youshould�attendfor�lunch.

13:15Alumni�Association�AGM�andLunch (Peggy�Turner�Room)

Session�3�-�chaired�byProfessor�Mauro�Perretti

14:30

Session 3 Cchaired by Professor

Robin Brook CentreAll�lectures�and�oral�presentations�will�be�takingplace�in�the�Morris�Lecture�Theatre�which�issituated�in�the�Robin�Brook�Centre.�Please�note�that�once�the�lecture�theatre�is�full,�you�will�be�directed�to�either�the�Patterson�Ross�or�Bainbridge�Room�where�the�sessions�can�be�watched�on�a�big-screen.��

St Bartholomew the GreatThe�St.�Luke’s-tide�service�will�take�place�in�thechurch�of�St�Bartholomew�the�Great�at�6pm�whichis�located�2�minutes�walk�from�St�Bartholomew’sHospital.�If�you�are�joining�the�academicprocession,�your�gown�will�be�available�in�the�Great�Hall�from�5pm.

Haberdashers’ HallIf�you�have�booked�to�attend�the�subscriptiondinner,�this�will�take�place�at�the�Haberdashers’Hall,�18�West�Smithfield.�This�is�a�1�minute�walkfrom�St.�Barts�Hospital�and�is�shown�on�the�map

Venue Information

The Great Hall and Pathology MuseumThe�event�registration�desk�is�located�just�inside�the�main�entrance�to�theGreat�Hall�and�a�cloakroom�is�also�available�here.�Coffee�and�Lunch�will�beserved�in�two�separate�venues;�the�Great�Hall�and�the�Pathology�Museum(located�in�the�Pathology�Building).�Posters�will�also�be�displayed�in�bothvenues.�To�ensure�you�can�view�all�posters�and�prevent�overcrowding�ineach�venue,�the�front�of�this�programme�indicates�which�venue�youshould�attend�for�the�morning�coffee�break�and�lunch.

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Programme

8.30Coffee/Tea�–�Registration��-Robin�Brook�Centre�&�GreatHall�Barts

8.50Welcome:�Professor�RichardTrembath,�Vice-Principal�andExecutive�Dean�(Health),�Bartsand�The�London�School�ofMedicine�and�Dentistry

9.00Session 1 –�(Chair:Professor�Fran�Balkwill)

1.Hot�Topic�in�Science:�Dr�Miguel�Branco,�Centre�forNeuroscience�and�Trauma,Blizard�Institute:�“Epigeneticsof�cytosine�modifications�“

9.152. Oral�presentation:��Dr�Paula�Longhi,�Centre�forInflammation,�William�HarveyResearch�Institute:�“DendriticCell�Maturation�and�CellMetabolism”

9.303. Oral�presentation:�Dr�DavidBrierley,�Centre�for�MolecularOncology,�Barts�CancerInstitute:�“Targeting�MismatchRepair�Deficiency�inTemozolomide�ResistantGlioblastomas”

9.454. Student�presentation:�Shen-Han�Lee:�“Imaging�pHwith�Magnetic�Resonance:Carbonic�Anhydrase�IX�as�pH-stat�that�Sets�TumourExtracellular�pH�In�vivo”

10.00Schorstein�Lecture:�Ms�ClareMatterson,�Wellcome�Trust:“Learning�is�Learning�“Introduced�by�Professor�MikeCurtis

10.45Coffee/Tea�Great�Hall�&�Pathology�Museum

11.30Session 2 –�(Chair:Professor�David�Kelsell)

1.Hot�Topic�in�Science:��DrKatiuscia�Bianchi,�Centre�forMolecular�Oncology,�BartsCancer�Institute:�“Survivingstrategies�of�cancer�cells:�fromevading�cell�death�to�rewiringmetabolism“�

11.452. Oral�presentation:�Dr�Yung-Yao�Lin,�Centre�for�CutaneousResearch,�Blizard�Institute:“Molecular�pathogenesis�ofmuscular�dystrophy�“

12.003. Oral�presentation:�Dr�TomNightingale,�Centre�forMicrovascular�Research,William�Harvey�ResearchInstitute:�“Controlling�therelease�of�bioactive�moleculesfrom�endothelial�cells”

12.154. Student�presentation:Gabriel�Doctor:�“Epigeneticanalysis�of�common�childhoodbrain�tumours�revealsdifferences�in�keydevelopmental�genes”.

12.30Sir�Anthony�Dawson�Lecture:Professor�Jack�Cuzick,�WolfsonInstitute:�“Progress�in�theprevention�of�breast�cancer”Introduced�by�Professor�SirNicholas�Wald.

13.15-14.30Lunch�and�poster�display�in�theGreat�Hall�and�the�PathologyMuseum

13.15Alumni�Association�lunch�&AGM�–�Peggy�Turner�Room,Barts

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14.30Session 3 –�(Chair:�ProfessorTim�Warner)

1.Hot�Topic�in�Science:�DrCarles�Gaston-Massuet,�Centrefor�Endocrinology,�WilliamHarvey�Research�Institute:“Paediatric�pituitary�tumours:the�answer�is�blowing�in�theWnt”

14.452. Oral�presentation:�Dr�KellyMarno,�Centre�for�Immunologyand�Infectious�Disease,�BlizardInstitute:�“HIV�restriction:�Thebattle�for�dominance“

15.003. Student�presentation:Martha�Wildemann,�Centre�forImmunology�and�InfectiousDisease,�Blizard�Institute:“Pollution�and�immuneregulation�in�the�human�airway:modulation�of�dendritic�cellfunction�by�environmentalparticulate�matter”

15.154. Oral�presentation:��Dr�KatieMoore,�Centre�for�TumourBiology,�Barts�Cancer�Institute:“Targeting�Integrin�αvβ6:�anovel�treatment�of�aggressivebreast�cancer�“

15.30William�Harvey�Lecture:Professor�Sir�Peng�Khaw,Professor�of�Glaucoma�andOcular�Healing,�Institute�ofOphthalmology,�UCL�andMoorfields�Hospital:�“Found�intranslation�–�a�vision�of�thefuture“�Introduced�byProfessor�Richard�Trembath��

16.20Prize�giving�for�oralpresentations�and�posters�byProfessor�Richard�Trembath�–Vice�Principal�and�ExecutiveDean�(Health).

16.30Summing�up�-�The�Vision�forthe�SMD�–�Professor�RichardTrembath

16.40Afternoon�Tea�andRefreshments,�Great�Hall

17.30-17.50Robing�for�the�Academicprocession�to�St�Bartholomewthe�Great�will�take�place�in�theHenry�VIII�Room,�North�Wing.

17.50Academic�procession�leavesthe�North�Wing

18.00St�Luke’s�Tide�Service,�StBartholomew�the�Great

The�address�will�be�given�byProfessor�Michael�Reiss,Professor�of�Science�Educationand�Pro-Director�Research�andDevelopment,�Institute�ofEducation,�and�the�lessons�willbe�read�by�Professor�TrishaGreenhalgh�and�Professor�MikeCurtis.

19.15Pre-Dinner�drinks�reception�–Haberdashers’�Hall.

19.45Dinner�–�Haberdashers’�Hall�

Grace�will�be�said�by�the�Rev'dProfessor�Nick�Goulding.

After�dinner�speech�by�the�VicePrincipal�&�Executive�Dean(Health),�Professor�RichardTrembath.

Poster PresentationsGreat Hall

1�Rosalind Cutts BCI�A�Bioinformatics�Portal�for�theBreast�Cancer�Campaign�TissueBank

2Prabhu Arumugam BCI�Role�of�pIgR�in�pancreacticadenocarcinoma

3�Elzbieta Stankiewicz BCI�Genomic�changes�in�prostatecancer�bone�metastases

4Nuria Coll Bastus BCI�Androgen-Induced�TMPRSS2and�ERG�Spatial�Proximity

5Dr Noor Jawad BCIMethylation�signatures�of�non-expressed�genes�reveal�insightsinto�the�effects�of�inflammationon�stem�cell�dynamics�and�cryptfission�in�Inflammatory�BowelDisease

6�Michael Allen BCIDoes�expression�of�avb6�in�DCISassociated�myoepithelial�cellsdrive�macrophages�towards�atumour�promoting�phenotype?

7�Jenny Cook BCIClassical�monocytes�frompancreatic�ductaladenocarcinoma�patients�have�asignificantly�alteredtranscriptomic�profile�comparedto�healthy�donors

8�Colan Ho-Yen BCI�Clinical�significance�of�c-Met�ininvasive�breast�cancer

9�Sarah McClelland BCIReplication�stress�links�structuraland�numerical�cancerchromosomal�instability

10Rita Ribeiro Coutinho BCIA�Diffuse�Large�B-cell�lymphomaassociated-macrophagetranscriptome�analysis�reveals�aunique�M1-M2�polarizationwhich�challenges�currentconcepts�on�the�lymphomamicroenvironment

11�Naoki Kishi BCI�A�novel�role�of�14-3-3gamma�as�aregulator�of�c-Met�signalling

12Jacek Marzec BCI�A�bioinformatics�portal�for�cross-platform�analysis�of�global�cancerprofiles

13Daniel Foxler BCIThe�Tumour�Suppressor�ProteinLIMD1�is�Critical�for�ChronicHypoxic�Degradation�of�HIF1αand�the�Hypoxic�Response


The following posters are located in the Great HallAll�posters�will�be�displayed�in�the�Great�Hall�and�Pathology�Museum�from�8.30am�until�2.30pm

Abbreviations: BCI: Barts Cancer InstituteBICMS: Blizard Institute of Cell and Molecular Science.IHSE: Institute of Health Sciences Education.WHRI: William Harvey Research Institute.

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14Shah-Jalal Sarker BCI�Sample�Size�Determination�forCost-Effectiveness�Trials

15Katherine Bridge BCIRegulation�of�HIF-1�and�thehypoxic�response�by�the�tumoursuppressor�LIMD1

16Natasha Sahgal BCI�Breast�Cancer�FieldCancerization:�genotypic�&phenotypic�investigations

17Sybil Wong BCITumour�suppressor�LIMD1�is�aprotein�scaffold�that�is�critical�forthe�function�of�the�microRNA-induced�silencing�complex(miRISC)

18Alexia Hervieu BCIUnderstanding�and�targetingPI3K�pathway�downstream�of�Metoncogenic�mutant

19Jennifer Watt BCI�The�role�of�Pentraxin�3�(PTX3)�inpancreatic�cancer

20Abbie Fearon BCI�Investigating�the�functionaleffects�of�FGFR2�mutations�inendometrial�cancer

21Laura King BCIA�novel�cell�line�model�toinvestigate�early�high�gradeserous�ovarian�cancer�(HGSC)

22Margueritte El Khouri BCIMechanisms�of�immunogeniccell�death�and�induction�ofspecific�anti-tumour�immunityelicited�by�different�oncolyticviruses

23Delphine Guillotin BCITriamterene�induces�selectivelethality�in�DNA�mismatch�repairdeficient�cell�lines

24Emanuela Gadaleta BCIIdentification�of�prognostic�multi-gene�signatures�capable�ofpredicting�outcome�in�patientswith�triple�negative�and�basal-likebreast�cancer

25Chiara Berlato BCIAntagonists�of�the�chemokinereceptor�CCR4�reverse�the�tumor-promoting�microenvironment�ofrenal�cancer

26Caroline Besley BCI�Improving�Alloreactivity�UsingLenalidomide

27Edmund Wilkes BCIDeep�analysis�of�signallingplasticity�in�a�breast�cancerkinase�network�during�acquisitionof�resistance�to�PI3K�andmTORC1/2�inhibitors

28Ajanthah Sangaralingam BCIO-miner:�an�integrative�platformfor�the�automated�analysis�andmining�of-omics�data


29Floriana Manodoro BCILoss�of�imprinting�at�the�14q32domain�reactivates�microRNAexpression�in�acutepromyelocytic�leukaemia

30Dayem Ullah BCI�The�Pancreatic�ExpressionDatabase

31Laura Gay BCI�Investigating�clonal�evolution�inhuman�colorectal�adenomas

32Zareen Khan BCIProteomic�analysis�of�the�stromaidentifies�potential�therapeutictargets�for�RDEB

33Eiman Mohammad BCI�Investigation�of�CNR1�as�a�tumorsuppressor�gene�at�6q15�inprostate�cancer

34Stuart McDonald BCIThe�stem�cell�organisation,�andthe�proliferative�and�geneexpression�profile�of�Barrett’sepithelium,�indicates�and�originfrom�gastric�glands

35Caroline Sproat BCI�Integrin�ανβ6�regulation�ofinvasion�in�breast�cancer

36Sarah Spear BCI�The�role�of�B�cells�in�pancreaticcancer

37Ann-Marie Baker BCITwo-dimensional�mapping�of�theevolution�of�clonal�lineages�inhuman�colonic�crypts�revealsstem�cell�dynamics�andmigration�patterns

38Echo Mao BCIIdentification�of�two�new�lociassociated�with�prostate�cancerin�Chinese�men�using�the�iCOGScustom�SNP�array

39John Foster BCIAn�organotypic�model�of�theHuman�Bronchial�LungEpithelium�for�the�study�of�lungtumorigenicity�and�drug�targetvalidation

40Sarantos Kaptanis BCITargeting�Field�Cancerizationand�Microenvironment�in�BreastCancer

41Biancastella Cereser BCIClonal�expansion�andprogression�of�Ductal�Carcinomain�situ�to�cancer�in�the�humanbreast

42Eleni Kotsiou BCIPhenotypic�and�functionalcharacterisation�of�alloantigen-specific�regulatory�t�cellsexpanded�after�in�vitroanergisation�with�co-stimulatorymolecule�blockade


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43Khairiya Ahmed BCIChanges�in�themicroenvironment�of�DCIS:�therelationship�between�alteredmyoepithelial�cell�phenotype�andinflammatory�infiltrate

44Elayne Hondares BCI�The�proton�channel�HVCN1�andits�isoforms�in�B�cellmalignancies

45Emma Mercer BCIA�novel�approach�to�prostatecancer�therapy�using�TMPRSS2promoter�activity

46Dr Anna Vossenkaemper BICMSA�role�for�gut-associatedlymphoid�tissue�in�shaping�thehuman�B�cell�repertoire

47Beshoy Reyad BICMSDo�calcium-dependantpotassium�channels�have�apotential�role�in�the�modulation�ofvisceral�nociception?

48Dr Gary Warnes BICMS�Flow�Cytometric�Measurement�ofCell�Organelle�Phagy

49Andrea Perera BICMS�Characterising�the�effect�ofsubstrate�stiffness�onmacrophage�behaviour

50Xuenong Bo BICMSIntraneural�ATP�injection�stronglystimulates�regeneration�ofprimary�sensory�axons�in�thespinal�cord

51Fiona Kenny BICMS�Matrix�elasticity�regulateskeratinocyte�proliferation

52Madeleine Moore BICMS�A�siRNA�screen�to�re-activatesenescence�in�cancer

53Dr Amanda Adegboye BICMSIntakes�of�calcium,�vitamin�D�anddairy�products�in�relation�todental�plaque�in�older�Danishadults

54Georgios Theocharidis BICMS�The�role�of�type�VI�collagen�in�theskin

55Dr Amir Sharili BICMSCharacterisation�of�nuclear�actindynamics�and�function�inepidermal�keratinocytes

56Ashley Thorpe BICMSReversal�of�il-1β-inducedtolerance�in�intestinal�epithelialcells�by�s-adenosyl-l-homocysteine

57Dev Priya Singhvi BICMS�Haemoglobin�at�birth�and�bloodtransfusion�in�preterm�infant�≤32weeks


58Zhuo-Hao Liu BICMSEffects�of�ω3-polyunsaturatedfatty�acid�in�a�rodent�model�ofcervical�spinal�cord�injury

59Jo Gibbs BICMSThe�development�of�an�onlineclinical�consultation�for�theremote�management�of�genitalChlamydia�trachomatis

60Patricia Costa BICMSDirecting�cell�migration�andpolarity�using�micro-patternedand�dynamically�adhesivepolymer�brushes

61Amy Coulden BICMS�The�role�of�small�GTPases�in�HIVentry

62Sebastian Fuller BICMSThe�impact�of�public�and�patientinvolvement�on�the�design�andimplementation�of�theSportsmart�pilot�clusterrandomised�control�study�of�STIscreening�in�football�clubs

63Zoe Drymoussi BICMS�Matrix�metalloproteinases�inkeloid�scarring

64Ruth Angus BICMSA�model�of�traumatic�brain�injuryin�the�mouse�–�investigation�of�anomega-3�fatty�acid�for�acuteneuroprotection

65Dr Neil McCarthyBICMSHuman�Intestinal�Vδ2+�T-cellsProduce�Elevated�Levels�of�TNFαand�are�Ablated�by�AzathioprineTherapy�in�Crohn’s�Disease

66Allon Hazan BICMSLipocalin�2�regulates�multipletumour-associated�mechanismsincluding�estrogen�and�androgenreceptor�in�prostate�cancer�cells

67Allon Hazan 2 BICMSIn�vitro�modeling�of�Basal�CellCarcinoma�reveals�that�GLI1�isactivated�by�nuclearSMOOTHENED;�a�mechanismthat�is�insensitive�to�anti-SMOcompounds

68Paul Batty BICMS�Amino�acid�sequence�epitopemapping�of�factor�VIIImonoclonal�antibodies

69Ioanna Mavrommati BICMSInvestigating�the�intracellularfunctions�and�signallingpathways�regulated�by�Class�IIPhosphoinositide�3-Kinases

70Syamsul Arifin BICMS�Role�of�Lysophosphatidylinositoland�Its�Putative�Receptor(s)�inDiabetes


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71William Dawes BICMS�Neural�Stem�Cells�as�therapeutictargets�in�Germinal�MatrixHaemorrhage

72Emily Ruban BICMS�Targeting�ABC�transportersautocrine�loop�in�prostate�cancer

73Ashirwad Merve BICMSPolycomb�gene�Bmi1�controlsmedulloblastoma�invasionthrough�inhibition�of�BMP-mediated�cell�adhesion

74Simona Mazza BICMS�Role�of�class�II�phosphoinositide3-kinase�C2α in�pancreatic�βcells

75Raj Lahiri BICMSTLR�expression�and�innateimmune�responses�predict�post-operative�systemic�inflammatoryresponse�syndrome�followingmajor�HPB�resection

76Dr Lida Kourita BICMSChildhood�injury�in�TowerHamlets,�one�of�the�mostdeprived�inner�city�Londonboroughs;�Prospective�audit�datafrom�the�Royal�London�Hospital

77Francesca Ammoscato BICMSLipopolysaccharide-inducedgenes�which�are�tolerized�inhealthy�control�bloodderivedmacrophages�are�up-regulatedin�inflammatory�bowel�diseasegut�macrophages

78Colin Millard BICMSThe�role�of�social�networks�inshaping�the�evidence�base:�acase�study�of�the�addition�ofMisoprostol�to�the�WHO�EML�foruse�in�the�prevention�ofPostpartum�Haemorrhage

79Ngoc Nguyen BICMSHOXA7�suppresses�keratinocytedifferentiation�by�inactivating�thePKC/AP-1�pathway

80Dr Richard Waite BICMSPopulation�dynamics�andvirulence�potentiation�in�mixedculture�biofilms�of�Pseudomonasaeruginosa�and�oral�commensalstreptococci�is�strain�specific

81�Dr Eleni Pantazi BICMSGLI2�induces�genomic�instabilityin�human�keratinocytes�byinhibiting�apoptosis

82Peter Roderick BICMSRational�regulation�of�safe�andeffective�drugs�in�India:�are�law-makers�getting�serious?

83Louise Adams BICMSDistribution�of�perineuronal�netmolecules�in�the�adult�rat�spinalcord�and�in�cultured�embryonichippocampal�neurons


84Patrick Pallier BICMSA�new�injectable�form�ofdocosahexaenoic�acid�improvesfunctional�outcome�in�rodentsafter�spinal�cord�compressioninjury

85Aneta Kucik BICMS�Epigenetic�Regulation�of�GutMacrophages�in�InflammatoryBowel�Disease

86Dr Jayanta Banerjee BICMSEffect�of�blood�transfusion�oncerebral�and�intestinal�blood�flowduring�the�first�week�of�life�inextreme�preterm�infants

87James Hockley BICMSMechanotransduction�in�mousevisceral�afferent�fibres�ismodulated�by�voltagegatedsodium�channel�subtype�1.9(Nav1.9)

88Dr William Alazawi BICMS�Ethnicity�and�the�risk�of�NonAlcoholic�Fatty�liver�Disease

89Chanse Fyffe BICMS�PDK1�as�a�novel�therapeutictarget�in�Pancreatic�cancer

90Angela Kwan BICMS�Haemoglobin�at�birth�andoutcome�in�preterm�infants�born≤32�weeks

91Milosz Kostusiak BICMSTreatment�with�the�omega-3�fattyacid�docosahexanoic�acidreduces�the�upregulation�ofchondroitin�sulphateproteoglycans�and�increasesplasticity�following�spinal�cordinjury

92Anke Nijhuis BICMSMicroRNA�expression�profilingidentifies�miR-29b�as�a�relevantanti-fibrogenic�factor�in�Crohn’sdisease�intestinal�strictures

93Patricia McGettigan 2 BICMSWhat�is�the�effect�of�regulation?The�impact�of�a�change�inregulation�on�the�availability�offixed�dose�combination�drugs�fordiabetes�in�India

94K L Ward BICMSEstablishing�a�baseline�tomonitor�equity�of�access�in�thegeographical�distribution�ofCommunity�Pharmacies�in�SouthAfrica�as�a�prelude�to�theNational�Health�Insurance

95Esther Atukunda BICMSA�Global�Assemblage�of�CivilSociety�Organizations�andmedicines�policy�change:�A�casestudy�of�registration,procurement,�distribution�anduse�of�misoprostol�in�Uganda

96Karen Maigetter BICMSPharmacovigilance:Determinants�of�a�CriticalRegulatory�Issue�in�India,Uganda�and�South�Africa



97Abhay Kadam BICMSQuality�and�safety�of�medicinesin�Maharashtra,�India:�A�criticalappraisal�of�drug�regulatorycapacities�for�inspections�ofmanufacturing�and�sales�units

98Isma Ali BICMS�Imaging�techniques�of�theBlizard�Advanced�LightMicroscopy�facility

99Shuang Gu BICMS�Bioinformatics�and�structuralstudies�of�the�human�anti-viralprotein�Bliz1

100Riccardo Ferro BICMSEmerging�role�of�ABCtransporters,�G-protein�coupledreceptors�and�lysophospholipidsin�pancreatic�and�colorectalcancer

101Hemanth Tummala BICMS�Mutations�in�ERCC6L2�genecause�bone�marrow�failure

102Jamie Upton BICMSOxidative�stress�plays�a�directrole�in�mediating�DHT-stimulated�TGF-βsecretion�bydermal�papilla�cells

103Philip Bland BICMS�Genetic�and�functionalmechanisms�underlyingHarlequin�Ichthyosis

104Liz Steed and KaterinaKassavou BICMSDesigning�a�novel�smokingcessation�intervention�incommunity�pharmacies�usingtheory-based�analysis�ofsuccessful�health�promotionprogrammes:�a�systematicliterature�review

105Valerie Evans BICMSHow�robust�is�the�regulatoryapproval�process:�a�case�studyassessing�the�safety�and�efficacyof�two�metformin�fixed�dosecombinations�used�for�treatingType�2�Diabetes�in�India

106Matthew Caley BICMS�Diverse�roles�for�laminin�332subunits�in�squamous�cellcarcinoma

107Emily Ruban 2 BICMSPhospholipase�C�beta4�regulatesmigration�and�proliferation�incutaneous�SCC

108Supatra Marsh BICMS�The�role�of�the�basementmembrane�in�epidermalhomeostasis

109Edel O'Toole BICMSType�VII�collagen�acts�as�a�tumorsuppressor�in�skin�by�regulatingTGFb�and�angiogenesis

110John Broad BICMSGender-�and�regionally-specificdecline�in�colonicneuromuscular�activity�withadvanced�age

111Deborah Robinson BICMSDissecting�the�role�of�iASPP,�anovel�crucial�regulator�ofepidermal�homeostasis,�inkeratinocyte�skin�carcinogenesis

112Viviana Robles BICMSFunctional�characterisation�anddevelopment�of�3-D-histotypicmodel�of�the�human�eccrinesweat�gland�secretory�coil

113Stuart Skelton BICMSFactor�V�protectionism�againstallo-antibodies�production�inHaemopilia�A�patients

114Theodore Sanders BICMSRetinoic�acid�generation�byhuman�intestinal�CD14+macrophages�is�enhanced�inCrohn’s�disease�and�maintainsan�inflammatory�phenotype

115Ana Alonso BICMS�Human�PAF1�inhibition�of�HIV-1

116Danushan Srirathan & Flora Gunaratnam BICMSBmi1�epigenetically�modulatesepidermal�stem�cells�viaregulation�of�Wnt/β-cateninsignalling

117Chris Mathews & Sarah FinerBICMSMaternal�gestational�diabetes�isassociated�with�genome-widemethylation�variation�in�placentaand�cord�blood�of�exposedoffspring

118Nital Sumaria BICMS�A�requirement�for�PI3K�in�gd�Tcell�development




Poster PresentationsPathology Museum

1Benjamin Fell BICMS�In�vitro�Human�Skin�Model�forthe�Assessment�of�Nano-basedDrug�Delivery

2Holly Lyne IHSE�Do�students�need�a�flexible,�part-time�medical�degree?

3Kerrie Wilson IHSEStudent�Perceptions�Towards�theEfficacy�of�Peer�Representationat�Medical�School

4Aaron Braddy IHSECan�trained�consumer�ledintimate�examination�teachingimprove�learning�outcomesamongst�medical�students?�Asystematic�review�of�comparativeeffectiveness�evidence

5Marek Perera IHSE�Improving�Student's�Confidencewith�Evidence-Based�Medicine

6Dr Cecilia Gonzales-MarinInstitute�of�DentistryA�Simplified�Technique�toInvestigate�the�Associationbetween�Oral�Fusobacteriumnucleatum�subspeciespolymorphum�and�AdversePregnancy�Outcomes

7Xiaojing ChenInstitute�of�Dentistry�Novel�highly�degradable�chloridecontaining�bioactive�glasses

8Emma JamesInstitute�of�DentistryIncreased�lactate�production�isrestrained�by�p53�in�the�absenceof�altered�ROS�production�butdoes�not�require�the�cell�cycleeffectors�p16INK4A�or�p21WAFfor�induction�by�DNA�damage-induced�senescence

9Ms Marilena SiailiInstitute�of�Dentistry�Autograft�and�enamel�matrixderivatives�in�root�coverage:�acase�report

10Ali Ahmed Bani HamourInstitute�of�Dentistry�Surgicalexcision�of�an�epulis,�case�reportPathology�Museum

11Dr Arthi AnthonyInstitute�of�Dentistry�TIME-LAPSE�IMAGING�OFHARD�TISSUEDEMINERALIZATION

12Bana AbdulmohsenInstitute�of�DentistryFlexural�And�Compressivestrengths�of�Two�CommercialProvisional�Restorations�AfterImmersion�in�Solutions

The following posters are located in the Pathology Museum


13Dominiki ChatzopoulouInstitute�of�DentistryEnamel�matrix�derivatives�for�softand�hard�tissue�augmentation�indentistry:�clinical�applications�ofthe�regenerative�material�in�twocase�reports

14Abdirahman AdenInstitute�of�Dentistry�Using�OCT�to�InvestigateTopographical�Changes�ofEnamel�During�Erosion

15Abish StephenInstitute�of�DentistryIn�vitro�and�in�vivo�investigationsin�to�the�role�of�Solobacteriummoorei�in�oral�malodour

16Samiul HasanInstitute�of�DentistryAtypical�T�cells�in�Behçet’sdisease�and�their�co-relation�withother�immune�cells

17Scheila ManicaInstitute�of�Dentistry�A�study�of�Cervical�Vertebrae�anddental�maturation

18Helen LiversidgeInstitute�of�Dentistry�Early�prediction�of�mandibularsecond�premolar�agenesis

19Narinder DhadwalInstitute�of�DentistryThe�association�between�oralmalodour,�periodontal�diseaseand�the�level�ofperiodontopathogens�in�variousoral�habitats�using�qPCR

20Niamh O'RourkeInstitute�of�DentistryThe�Clinical�and�CostEffectiveness�of�BondedRetainers�and�Vacuum�FormedRetainers�in�the�Lower�Arch:�ARandomised�Controlled�ClinicalTrial

21Sowmya GopineediInstitute�of�DentistryA�Systematic�review�comparingthe�efficacy�of�interdentalbrushes�versus�dental�floss,�asan�adjunct�to�toothbrushing,�ondental�plaque�and�gingivitis�inadults

22Nicola SharmaInstitute�of�DentistryA�Laboratory�Based�ComparativeStudy�of�OrthodonticThermoform�Retainer�Materials

23Elena TaliotiInstitute�of�DentistryA�case-report�on�the�treatment�ofidiopathic�gingival�hyperplasia�ina�39�yearold�female

24Neera JosephInstitute�of�Dentistry�In�Vitro�Study�on�CariostaticEffect�of�Poly�(L-glutamic�acid)

25Dr Paul AndersonInstitute�of�DentistryEffect�of�Cu2+�on�HydroxyapatiteDemineralisation�Relevant�toDental�Caries�Studied�UsingScanning�Microradiography

26Professor Robert HillInstitute�of�DentistryPolygamma�Glutamic�AcidReduces�Kinetics�ofHydroxyapatite�Demineralizationunder�Caries-SimulatingConditions



27Ashar JamelleInstitute�of�Dentistry�Root�resection,�a�case�report

28Dr Saroash ShahidInstitute�of�DentistryMeasurement�of�Radiopacity�ofModern�Commercial�GlassIonomer�Cements

29Hanan MoftahInstitute�of�DentistryEvidence�for�DSG3�in�regulatingcell-cell�adhesion�by�amechanism�of�affecting�E-cadherin�trafficking

30Kajal GohilInstitute�of�DentistryAn�evaluation�of�the�anatomicalrelationship�of�the�mentalforamen�and�mandibular�teethfrom�Cone�Beam�ComputedTomography�scans

31Patricia AyayenInstitute�of�Dentistry�Dose�comparison�from�differentvolumes�of�cone�beam�ct

32Priyen ShahInstitute�of�DentistryZinc�and�fluoride�containingbioactive�glasses�in�desensitizingtoothpastes

33Jie LiuInstitute�of�DentistryStrontium-substituted�bioactiveglasses�with�higher�phosphate�toenhance�osteogenesis

34Ali Ahmed Bani Hamour 2Institute�of�Dentistry�Gingival�Epulis,�case�report

35Talha NayabInstitute�of�DentistryOral�Health�Care�DeliverySystems�for�Caries�Inhibition�byStatherin-like�Peptides

36Paul RyanInstitute�of�Dentistry�Phenotypic�characterisation�ofHuman�Vγ9Vδ2�T-cells�in�healthand�disease

37Rawan AlbeshtiInstitute�of�DentistryMAS-NMR�study�of�settingreaction�and�remineralisation�ofglass�ionomer�cements

38Iad GharibInstitute�of�DentistryQuantification�of�Three�RootCanal�Obturation�TechniquesQuality�Using�X-�‐‑RayMicrotomography�In-�‐‑vitro

39Jamila AlmuhamadiInstitute�of�DentistryDevelopment�of�diopside�glass-ceramics�for�dental�andbiomedical�applications

40Eleni Hagi-PavliInstitute�of�Dentistry�Apoptotic�Protein�Expression�inOral�Ulceration

41Evelyn PadtongInstitute�of�DentistryA�case-report�on�the�treatment�ofdelayed�passive�eruption�in�a�16year-old�male


42Preeti JauharInstitute�of�DentistryA�clinical�investigation�to�assesstreatment�adherence,�with�aremovable�oral�appliance,�inpatients�with�obstructive�sleepapnoea�hypoponea�syndrome

43Amani AghaInstitute�of�Dentistry�Water�Uptake�of�Resin�ModifiedGlass�Ionomer�Cements(RMGICs)

44�Suzanne Eldridge WHRI�Agrin:�a�new�endogenouschondrogenic�molecule�forcartilage�repair

45Rachael Wright WHRIModulation�of�galectin-3expression�in�murine�neutrophilsoccurs�both�temporally�andspatially�during�a�resolvinginflammatory�response

46Xiangyuan Pu WHRIADAMTS7�cleavage�and�vascularsmooth�muscle�cell�migration�isaffected�by�a�coronary-artery-disease-associated�variant

47Bethan Thomas WHRIThe�role�of�WNT16�in�cartilagerepair�and�OA:�WNT16�supportslineage�identity�in�articular�andepiphyseal�chondrocytes

48Alex Doyle WHRI�Annexin�a1�in�cystic�fibrosisairway�pathology

49Ajantha Sinniah WHRIAnx-A1�acts�as�an�endogenous‘brake’�on�mast�celldegranulation�and�activation

50Stefania Bena WHRI�The�impact�of�FPRs�on�AnnexinA1�cardioprotection�in�vivo

51Emma Kay WHRISex-Differences�In�MonocyteRecruitment�In�A�Murine�ModelOf�Zymosan-Induced�Peritonitis

52Balraj Singh WHRIUnravelling�the�Role�of�T�cell-derived�Annexin-A1�in�ObsessiveCompulsive�Disorder�andRelated�Diseases

53Dr James Whiteford WHRI�Dual�Roles�for�syndecan-4�inangiogenesis

54Dr Robin Poston & Maria MirzaWHRI�Intracellular�oxidation�of�LDL�inhuman�umbilical�vein�endothelialcells

55Trinidad Montero-MelendezWHRIAnnexin�A1�as�a�novel�effector�forthe�pro-resolving�properties�ofHDAC�inhibitors



56Nobuko Tano WHRIThe�use�of�allogeneicmesenchymal�stromal�cells�torefine�the�emerging�“cellsheet”technique�for�the�treatment�ofheart�failure

57Wai Yee James WHRI�Safety�and�efficacy�of�sputuminduction�in�COPD�patients

58Dr Paul Armstrong WHRI�Whole�blood�assay�forphenotyping�platelet�reactivity�inmice

59Maria Guerreiro WHRI�Advances�in�ATC:�pre-clinicalmodel�of�functional�coagulopathy

60Xiaotian Yu (Qingzhong Xiao)WHRIMicroRNA-34a�regulates�smoothmuscle�cell�differentiation�fromstem�cells�by�targeting�sirtuin�1

61Hanqing Zhao (Qingzhong Xiao)WHRIMicroRNA-22�regulates�smoothmuscle�cell�differentiation�fromstem�cells�by�targeting�methylCpG�binding�protein�2

62Guanmei Wen (Qingzhong Xiao)WHRI�Matrix�Metalloproteinase-8Mediates�Angiogenesis�in�Vitroand�in�Vivo

63Jianmin Chen WHRIGender�differences�in�themyocardial�dysfunction�causedby�co-administration�of�LPS�andpeptidoglycan�in�mice

64Maria Herincs WHRI�Prevalence�of�familial�isolatedpituitary�adenomas�(FIPA)

65Christopher Schultz WHRITreatment�of�rheumatoid�arthritiswith�progranulin;�a�growth�factorwith�antiinflammatory�and�pro-chondrogenic�properties

66Li Chan & Lou Metherell WHRI�Whole�exome�sequencing�as�adiagnostic�tool�for�adrenalinsufficiency

67Helen Storr WHRIGenetic�characterisation�of�shortchildren�with�potential�defects�ofGH�action�by�single�genesequencing

68Andrew Moore WHRIHypoxic�upregulation�of�mmp14expression�and�angiogenesis�isattenuated�by�simvastatin�viainhibiting�hif1α interaction�withthe�mmp14�gene�promoter

69Dr Evelien Gevers WHRI�The�role�of�growth�hormone�(GH)in�early�postnatal�life

70Hew Torrance WHRIPatterns�of�cytokine�geneexpression�are�related�tonosocomial�infectiouscomplications�following�severetrauma


71Hew Torrance 2 WHRIAssociation�between�geneexpression�biomarkers�ofimmunosuppression�and�bloodtransfusion�in�severely�injuredpolytrauma�patients

72Dr Petros Andrikopoulos WHRIInhibition�of�Ca2+�influx�throughthe�Na+/Ca2+-exchanger�(NCX)preserves�endothelial�barrierfunction�in�response�to�thrombin:evidence�from�in�vitro�and�in�vivomodels

73Mashal Hussain WHRI�Identification�ofACTH/Melanocortin�2�receptor(MC2R)�antagonists

74Patricia McGettigan WHRIRegulatory�confusion�andirrational�medicines�in�India:�Astudy�of�fixed�dose�combinationdrugs

75Miss Florence Johnson WHRI�Late�Inhibition�of�Inhibitor�of�IkBKinase�Attenuates�Acute�KidneyInjury

76Leo Dunkel WHRI�Novel�Genes�Affecting�the�Timingof�Puberty

77Giovanna Nalesso WHRIThe�WNT/CaMKII�pathway�isactivated�in�human�andexperimental�osteoarthritis�andpromotes�chondrocyte�de-differentiation

78Claudia Cabrera & MichaelBarnes WHRI�Investigation�of�the�mode�ofaction�of�Artesunate�at�amolecular�level

79Kenneth Chan WHRIChromosome�9p21�Locus�andCoronary�Artery�Disease�–Collaborative�Metaanalysison�Angiographic�Burden�andMolecular�Function�Analysis

80Jonas Bystrom WHRIDifferent�T-lymphocytes�drive�theinflammatory�response�inpatients�with�rheumatoid�arthritisand�determine�responsiveness�tobiologic�anti-TNFα agents

81Dr Taher Taher WHRIIdentifying�pathogenic�B-lymphocytes�and�suppressingtheir�immunopathogenic�roles�inpatients�with�systemic�lupuserythematosus

82Dr David Gould WHRIControlling�the�position�ofbioactive�molecules�inmicrocapsules�determines�theiractivity,�stability�and�cell�delivery

83James Floyd WHRI�New�Insight�into�theInflammatory�arthritistranscriptome�by�RNA-seq



84Dr Jennifer Bodkin WHRIDynamics�of�Neutrophil-Endothelial�Interactions�GovernsDissemination�of�LocalInflammation

85Andrew Findlay WHRIGalectin-3�perpetuatesprogressive�renal�interstitialfibrosis�in�Chronic�KidneyDisease

86Shea Addison WHRISequence�Analysis�of�Cardiac�IonChannelopathy�Genes�inUnexplained�Stillbirths

87Bartomeu Colom WHRILocal�cleavage�of�endothelial�cellJunctional�Adhesion�Molecule(JAM)-C�by�neutrophil�elastasegoverns�development�of�systemicinflammation

88Jo Sherwood WHRIcxcr2�signalling�is�required�forarticular�cartilage�homeostasis

89Elena Aflorei WHRIDrosophila�melanogaster�as�amodel�organism�to�study�arylhydrocarbon�receptor�interactingprotein�(AIP)�gene�function

90Professor Ania Korszun Wolfson�InstitutePsychosocial�factors�associatedwith�impact�of�cancer�in�longtermhaematological�cancer�survivors

91Dr Peter MacCallum Wolfson�InstitutePatient�safety�and�estimation�ofrenal�function�in�patientsprescribed�new�oralanticoagulants�for�strokeprevention�in�atrial�fibrillation

92Dr Feng J He Wolfson�Institute�Salt�Reduction�in�the�UK�–�ASuccessful�Experiment�in�PublicHealth

93�Ivana Sestak Wolfson�InstituteComparison�of�five�differentscores�for�the�prediction�of�laterecurrence�for�oestrogenreceptor�positive�breast�cancer

94Paul Cathcart Wolfson�InstitutePROVENT�-�A�randomised,double�blind,�placebo�controlledfeasibility�study�to�examine�theclinical�effectiveness�of�aspirinand/or�Vitamin�D�to�preventdisease�progression�in�men�onActive�Surveillance�for�low�riskprostate�cancer

95David Wald Wolfson�Institute�Randomized�Trial�of�PreventiveAngioplasty�in�MyocardialInfarction

96Lesley Ashdown-Barr Wolfson�InstituteAttitudes�towards�cervicalscreening,�HPV�testing�and�self-collected�samples�in�a�cervicalscreening�context:�a�mixedmethods�study�of�Hindu�womenin�London



100Neil Smith Wolfson�InstituteEthnic�differences�in�positivemental�wellbeing�and�depressionin�Bangladeshi�adolescents�inEast�London:�Findings�from�theOlympic�Regeneration�in�EastLondon�Study�(ORiEL)

101Alejandra Castanon Wolfson�InstituteRisk�of�preterm�delivery�withincreasing�depth�of�excision�forcervical�intraepithelial�neoplasiain�England:�nested�case-controlstudy

102Anna Springett 1 Wolfson�Institute�The�population�prevalence�ofDown�syndrome�in�England�andWales�in�2011

103Anna Springett 2 Wolfson�InstituteSurvival�of�trisomy�18�(Edwardssyndrome)�and�trisomy�13�(Patausyndrome)�in�England�andWales:�2004-2011

104Anna Springett 3 Wolfson�InstituteEpidemiology�of�congenitaldiaphragmatic�hernia,�Englandand�Wales,�2002-2011

105Oliver West Wolfson�Institute�Do�electronic�cigarettes�needaccurate�labelling�of�nicotinecontent?

106Adam Brentnall Wolfson�InstituteA�DNA�methylation�classifier�ofcervical�pre-cancer�based�onhuman�papilloma�virus�andhuman�genes

97Louise Cadman Wolfson�InstituteA�pragmatic�randomisedcontrolled�trial�of�response�to�aninvitation�to�selfsampling�forhuman�papillomavirus�(HPV)versus�repeat�invitation�forcervical�cytology�screening�inpersistent�non-responders�inNewcastle-upon-Tyne�-�theSHINE�Trial

98Kawther Hashem Wolfson�Institute�Salt�content�in�cheese�–�a�majorcontributor�to�salt�intake�in�theUK

99Vanathi Tharmaratnam Wolfson�InstituteAssociations�betweenNeighbourhood�Deprivation�andadolescent�mental�health:Examining�the�role�ofNeighbourhood�Perceptions

The�Anatomical�Paintings�of�Professor�Peter�Cull�MBE,�FMAA,HonFIMI,�OBSt.J�(1927�–�2012),�Emeritus�Professor�of�Medical�Art,University�of�London

We�are�delighted�that�William�Harvey�Day�will�feature�a�display�ofselected�reproductions�of�the�anatomical�paintings�of�thisconsummate�medical�artist�from�the�retrospective�of�his�workearlier�this�year�at�The�Royal�College�of�Physicians,�entitled‘Draughtsmanship�Dissected�–�The�Genius�of�Peter�G.�Cull’.�

Professor�Cull�was�Medical�Artist�to�The�Medical�College�of�St.Bartholomew’s�Hospital�from�1961�to�1993.�His�was�the�first�andstill�only�Chair�in�Medical�Art�to�be�awarded�in�Europe.�There�arearound�twenty-five�paintings�in�this�collection.�Only�‘Inflammation’was�commissioned;�the�remainder�were�created�purely�for�his�owndelectation.��Aesthetic�prowess�is�combined�with�informative,meticulous�depiction�of�human�anatomy,�each�stylisticallyimaginative.�Typically�audacious�in�the�use�of�media,�Peter�Culloften�mixed�pencil,�paint,�crayon,�and�graphite�dust�on�china�claysurfaced�boards.�

The�paintings�can�be�viewed�in�the�Great�Hall�throughout�the�day.The�School�is�very�grateful�to�Cedric�Gilson�for�providing�thesereproductions�for�display�at�William�Harvey�Day.


The�School�of�Medicione�and�Dentistry��is�very�grateful�to�theBarts�and�The�London�Charity�for�its�generous�support�forWilliam�Harvey�Day.

Thanks�go�to�Angus�Cameron�and�Marika�Charalambouswho�have�very�kindly�agreed�to�judge�the�Oral�Presentations,and�Paolo�Biancheri,�Richard�Sloan,�Ezra�Aksoy�and�TrevorGraham�who�are�judges�for�the�Poster�Display.

Documents

William Harvey Day 2013