To be published in Science is a special moment for any scientist. But to do so at

the very start of your career is extremely exciting indeed. If you are a recent PhD

graduate you could be published in Science this December, and receive a very

special prize in Stockholm during the week of Nobel.

Te journal Science & SciLifeLab have established Te Science & SciLifeLab Prize forYoung Scientists, to recognize and reward excellence in PhD research and support youngscientists at the start of their careers. It’s about bright minds, bright ideas and bright futures.

Four winners will be selected for this international award.Tey will have their essays publishedby the journal Science and share a new total of 60,000 USD in prize money. Te winnerswill be awarded in Stockholm during the second week of December when the city isalive with excitement and celebrates the new Nobel Laureates at the annual Nobel Prizeceremony. Tey will take part in a truly unique week of events including meeting leadingscientists in their felds.

“Te last couple of days have been exhilarating. It has been an experience of a lifetime.Stockholm is a wonderful city and the Award winning ceremony exceeds my wildest dreams.”–Dr. Dan Dominissini, 2014 Prize Winner

Who knows, having your work published in the journal Science could be a major steppingstone in your career and and the Science & SciLifeLab Prize for Young Scientists makesthis possible.

Te 2015 Prize is now open. Te deadline for submissions is August 1, 2015.Enter today: www.sciencemag.org/scilifelabprize

Te 2015 Prize categories are:

• Cell and Molecular Biology

• Ecology and Environment

• Genomics and Proteomics

• Translational Medicine

Tis prize is made possible with thekind support of the Knut and AliceWallenberg Foundation.Tis Founda-tion grants funding in two main areas;research projects of high scientifc poten-tial and individual support of excellentscientists.

Will you bepublished inScience thisDecember?(If you have a recent PhD you could be.)

Find out more about the scope of the journal and submit your research today!

ScienceTranslationalMedicine.org

WILLYOUR RESEARCH

LEAD TO BETTER LIVES

FOR PATIENTS?

Gopinath Sutendra and Evangelos D. Michelakis, “Pulmonary Arterial Hypertension: Challenges in Translational

Research and a Vision for Change”, Sci. Transl. Med. 5, 208sr5 (2013) Credit: Science Source

Eppendorf®, the Eppendorf logo, Eppendorf BioSpectrometer®, Eppendorf ThermoMixer®, and Eppendorf Xplorer® are

registered trademarks of Eppendorf AG, Germany. U.S. Design Patents are listed on www.eppendorf.com/ip

ODers may vary by country. All rights reserved, including graphics and images. Copyright © 2015 by Eppendorf AG.

Smart solutions for your cell biology processes—now with up to 21% of

As a workflow-oriented provider of lab

equipment, Eppendorf oDers instru-

ments, consumables, and accessories

that perfectly fit your processes in the

lab and thus your daily lab work. Our

comprehensive solutions are engineered

with smart innovations to simplify or

even eliminate cumbersome lab work.

Benefit now from substantial savings on:

> Eppendorf Xplorer® electronic

multi-channel pipettes

> Centrifuge 5702 R with rotor

> Eppendorf ThermoMixer® C

> Eppendorf BioSpectrometer®

fluorescence with UCuvette G1.0

> Divisible twin.tec PCR Plates 96

www.eppendorf.com/advantage

New Promotion March 1–June 30, 2015

Take Good Care of Your Cells

Learn more at: www.eppendorf.com/prize

2014 Winner

Eiman Azim, Ph.D.

Columbia University

For research on skilled

limb movement

Eppendorf & Science Prize for Neurobiology

The annual Eppendorf & Science Prize for Neurobiology

is an international award which honors young scientists

for their outstanding contributions to neurobiological

research based on methods of molecular and cell biology.

The winner and finalists are selected by a committee

of independent scientists, chaired by Science’s Senior

Editor, Dr. Peter Stern. To be eligible, you must be 35

years of age or younger.

You could be next to win this prize and to receive

> Prize money of US$25,000

> Publication of your work in Science

> Full support to attend the Prize Ceremony held in

conjunction with the Annual Meeting of the Society for

Neuroscience in the USA

> An invitation to visit Eppendorf in Hamburg, Germany

It’s easy to apply!

Call for EntriesApplication Deadline

June 15, 2015

AAAS®andScience®are

registeredtrademarksoftheAmericanAssociationfortheAdvancementofScience,USA.Eppendorf®andtheEppendorflogoare

registeredtrademarksofEppendorfAGGerm

any.

U.S.DesignPatents

are

listedonwww.eppendorf.com/ip.Allrights

reserved,includinggraphicsandim

ages.Copyright©

2015byEppendorfAG.KurstinRoePhotography.

Join Keystone Symposia in Asia for ourOctober Conferences on Nutrition and Diabetes

Diabetes: New Insights intoMolecularMechanismsand Therapeutic StrategiesOctober 25–29, 2015Westin Miyako Kyoto | Kyoto | Japan

Scientifc Organizers: Takashi Kadowaki, Juleen R. Zierath, Nobuya Inagaki and Barbara B. Kahn

The prevalence of type 2 diabetes is rising to epidemic proportions worldwide. Type 2 diabetes is a complex disease caused by dysfunctionofmultiple organ systems, and disease susceptibility is profoundly infuenced by both genetic and environmental factors. Thismeetingbrings together leading professionals in the academic and pharmaceutical communities with various specialties in diabetes research toshare new approaches and research paradigms. Themeetingwill present the latest discoveries in diabetes research, highlighting essentialaspects of diabetes, as well as emerging themes that are likely to provide novel therapeutic approaches.

Session Topics:• Islet Dysfunction in Diabetes• Regenerative Medicine in Diabetes• Gut Biology and Systemic Metabolism

• CNS Control of Metabolism

• Novel Insights into Adipocyte Biology•Molecular Mechanisms Underlying Insulin Resistance• Genetics and Epigenetics of Diabetes• Diabetes and Healthy Lifespan

HumanNutrition, Health and EnvironmentOctober 14–18, 2015ChinaWorld Hotel | Beijing | China

Scientifc Organizers: Martin Kussmann, Hannelore Daniel and Jacqueline Pontes Monteiro

Understanding interactions of nutrition and lifestyle with an individualÕs geneticmakeup is vital formaintaining health and delayingdisease onset. Toward that end, thismeeting aims to: 1) Bring together researchers from traditionally separated disciplines: nutrition, (gen)omics, clinics, physiology, epidemiology, analytics, biomathematics; 2) Advance nutrition research as a quantitative, holistic andmolecularscience; 3) Review/challenge classical pre-clinical models and clinical study designs, incorporating improved translational in vitro and invivomodels, human intervention study designs, and innovative new tools/technologies formolecular phenotyping; and 4) Connect basicscience to patient- and consumer-relevant outputs in terms of personalized dietary/nutritional counseling andmonitoring/diagnostics.

Session Topics:• The Interaction between Human Genome, Dietand Environment• Translational Models for Human Nutrition and Health• Human Nutritional and Lifestyle Interventions

• Capturing andMonitoring Human Individuality• From Nutrigenomics to Systems Nutrition• Nutrition 2.0 – Translation into Solutions for Human Health• Global Nutrition and Sustainability

Scholarship & Discounted Abstract Deadline: June 25, 2015; Abstract Deadline: July 23, 2015; Discounted Registration Deadline: August 25, 2015

For additional details, visitwww.keystonesymposia.org/15T2.

Global Health Travel Award Deadline (for investigators from developing countries): May 12, 2015;Scholarship & Discounted Abstract Deadline: June 16, 2015; Abstract Deadline: July 14, 2015; Discounted Registration Deadline: August 13, 2015

For additional details, visitwww.keystonesymposia.org/15T1.

1044 29 MAY 2015 • VOL 348 ISSUE 6238 sciencemag.org/products SCIENCE

LIFE SCIENCE TECHNOLOGIESNEW PRODUCTS

Produced by the Science/AAAS Custom Publishing Office

Bioreactor Systems

The new version of the ambr systems

(ambr 15 and ambr 250) are supplied

with integrated BioPAT MODDE Software

for Design of Experiments (DoE), pow-

ered by Umetrics. This allows bioprocess

scientists to easily implement DoE into

�� !����������������!� ����� ����-

timization and scale-up to larger single-

use BIOSTAT pilot and manufacturing

scale bioreactors, making bioprocess

development faster and more cost-

� ��! ���� �!�� ���� ������������� �

will enable scientists to quickly establish

a Design Space where relevant biopro-

cessing conditions are varied simultane-

�������� ���������!���������� �����

experiments via work packets that are

exported from the software to the ambr

���� ����������!��� �����!����!�� ��-

�����!���!������������ �� ���!���� ��-

ing parameters. The data generated

�����������!����!�����!� ������!����!��

analyzed within the software to identify

critical process parameters, optimize

�!���� ��!�������!�!���������� �� ���

robust design space for implementation

in larger single-use BIOSTAT pilot and

manufacturing scale bioreactors.

Sartorius Stedim Biotech

For info: 800-368-7178

www.sartorius.com

Liquid Metering Pump

The enhanced SIMDOS 10 line of dia-

phragm liquid metering pumps is avail-

able with four head material options. The

!� ������������������� ����� ��!���

simple operation, thanks to a user-friendly display and adjustable

transfer parameters from a touch-control knob. The SIMDOS 10

FT version features a PTFE head, a PTFE-covered diaphragm, and

chemically resistant FFKM Kalrez valves for the transfer of aggres-

sive chemicals. An optional Chemraz-valve kit allows the pump to

be used with highly concentrated acids such as nitric, sulphuric,

and hydrochloric acids and solvents such as TFH, DMF, DMSO, and

MEK. Also available with heads in PP, PVDF, or stainless steel, each

�����!���� �����������!� ������� ���!��!����!������������ ����

1ñ100 mL/min, and dose volumes of 1 mL up to 999 mL. In addition

�������������!�� ��!����!������ �������� ��� � ����� �� ���

stability and consistent reliability throughout its lifetime.

KNF Neuberger

For info: 609-890-8600

www.knfusa.com/simdos10

TIRF Illuminator

The new one-line illuminator (cellTIRF-

1L) complements the high-end four- and

two-line (cellTIRF MITICO 4L/2L) illumina-

tors. Ideally suited for use with laser com-

biners, the cellTIRF-1L with motorized

����������������������������������

���������������������������� ����������-

luminator can also be used with third-par-

�����������������������������������

samples to be sequentially imaged at the

���������������������� ����������������-

lessly managed by software integration

or via the Olympus Real-Time Controller

for accurate live cell imaging. As TIRF

imaging is invaluable across a wide spec-

trum of disciplines to investigate events

occurring at cell surfaces, the cellTIRF

illuminators provide a series of features

supporting both precise imaging and

easy operation. Among these features are

highly advanced optics, integrated laser

safety systems, and high-speed control of

penetration depth and laser lines via the

RTC. The high-end systems provide ul-

trasensitive truly simultaneous multicolor

TIRF microscopy, with up to four laser

channels and independent beam paths.

Olympus

For info: +49-(0)-40-23773-5913

www.olympus-lifescience.com

Scalable RNA-Seq Service

Stranded, ribodepletion, and globin re-

duction library construction options have

been added to the existing RNA-Seq

services. The Illumina TruSeq Stranded

Total RNA Sample Prep Kit has been au-

tomated on Beckman Coulter instruments to enable scalability and

������������������ ������������ �������� ��������� ����������

for human, mouse, rat, and plant samples and includes the ability

to work with samples derived from blood and FFPE tissue. This fully

automated sample preparation pipeline delivers consistent results

run after run, reducing user variability and bias, and allows process-

ing of a large amount of samples with reduced turnaround time rela-

��������� �������������� �������� ����������� �������� ������������

for genome annotation, de novo transcriptome assembly, and accu-

rate digital gene expression analysis thus providing uniform cover-

age and precise measurement of strand orientation, and discovery

across both coding and multiple forms of noncoding RNA.

Beckman Coulter Genomics

For info: 800-361-7780

www.beckmangenomics.com

Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.

Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations

are featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any

products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

Bioprocess Control Station

The BioFlo 320 is truly a step into the fu-

ture for Eppendorf as a bioprocess equip-

ment manufacturer. New features includ-

ing autoclavable and single-use vessel

�������������������������������������-

work communication for multiunit control

set it apart as the new premium choice in

the bench-scale bioprocess market. Suit-

able for microbial and cell culture, scale

up to scale down, batch, fed-batch, and

continuous processes, the BioFlo 320

can meet the ever-changing needs of all

segments of the biotech and pharmaceu-

�������� ������������������������������������

control, and maximum functionality while

occupying a fraction of the valuable lab

space of similar systems.

Eppendorf

For info: 800-645-3050

www.eppendorfna.com

@SciMagWebinars

antibodies

apoptosis

biomarkers

cancer

cytometry

data

diseases

DNA

epigenetics

genomics

immunotherapies

medicine

microbiomics

microfuidics

microscopy

neuroscience

proteomics

sequencing

toxicology

transcriptomics

VIEW NOW!

webinar.sciencemag.org

Learn about the latest breakthroughs, new

technologies, and ground-breaking research

in a variety of felds. Our expert speakers

explain their quality research to you and

answer questions submitted by live viewers.

watchourwebinars

technologies?want new

Brought to you by the Science/AAASCustom Publishing Ofce

CALL FOR PAPERSAbstract Submission Opens May 18, 2015 | Abstract Submission Deadline June 18, 2015

506 Keystone Drive • Warrendale, PA 15086-7573

Tel 724.779.3003 • Fax 724.779.8313

info@mrs.org • www.mrs.org

Don’t Miss These Future MRS Meetings!2016 MRS Spring Meeting & Exhibit

March 28 - April 1, 2016

Phoenix, Arizona

2016 MRS Fall Meeting & Exhibit

November 27 - December 2, 2016

Boston, Massachusetts

T. John Balk University of Kentucky

Ram Devanathan Pacifc Northwest National Laboratory

George G. Malliaras Ecole des Mines de St. Etienne

Larry A. Nagahara National Cancer Institute

Luisa Torsi University of Bari “A. Moro”

Meeting Chairs

ENERGY AND SUSTAINABILITY

LL Materials and Architectures for Safe and Low-Cost

Electrochemical Energy Storage Technologies

MM Advances in Flexible Devices for Energy Conversion and Storage

NN Thin-Film and Nanostructure Solar Cell Materials and Devices

for Next-Generation Photovoltaics

OO Nanomaterials-Based Solar Energy Conversion

PP Materials, Interfaces and Solid Electrolytes for High Energy Density

Rechargeable Batteries

QQ Catalytic Materials for Energy

RR Wide-Bandgap Materials for Energy EfRciency—

Power Electronics and Solid-State Lighting

SS Progress in Thermal Energy Conversion—

Thermoelectric and Thermal Energy Storage Materials and Devices

THEORY, CHARACTERIZATION AND MODELINGTT Topology in Materials Science—

Biological and Functional Nanomaterials, Metrology and Modeling

UU Frontiers in Scanning Probe Microscopy

VV In Situ Study of Synthesis and Transformation of Materials

WW Modeling and Theory-Driven Design of Soft Materials

XX Architected Materials—Synthesis, Characterization, Modeling and Optimal Design

YY Advanced Atomistic Algorithms in Materials Science

ZZ Material Design and Discovery via Multiscale Computational Material Science

AAA Big Data and Data Analytics for Materials Science

BBB Liquids and Glassy Soft Matter—Theoretical and Neutron Scattering Studies

CCC Integrating Experiments, Simulations and Machine Learning to Accelerate

Materials Innovation

DDD Lighting the Path towards Non-Equilibrium Structure-Property Relationships

in Complex Materials

X Frontiers of Material Research

A Engaged Learning of Materials Science and Engineering

in the 21st Century

BIOMATERIALS AND SOFT MATERIALSB Stretchable and Active Polymers and Composites

for Electronics and Medicine

C Tough, Smart and Printable Hydrogel Materials

D Biolological and Bioinspired Materials in Photonics and Electronics—

Biology, Chemistry and Physics

E Engineering and Application of Bioinspired Materials

F Biomaterials for Regenerative Engineering

G Plasma Processing and Diagnostics for Life Sciences

H Multifunctionality in Polymer-Based Materials, Gels and Interfaces

I Nanocellulose Materials and Beyond—

Nanoscience, Structures, Devices and Nanomanufacturing

J Wetting and Soft Electrokinetics

K Materials Science, Technology and Devices for Cancer Modeling,

Diagnosis and Treatment

L Nanofunctional Materials, Nanostructures and Nanodevices

for Biomedical Applications

NANOMATERIALS AND SYNTHESISM Micro- and Nanoscale Processing of Materials for Biomedical Devices

N Magnetic Nanomaterials for Biomedical and Energy Applications

O Plasmonic Nanomaterials for Energy Conversion

P Synthesis and Applications of Nanowires and Hybrid 1D-0D/2D/3D

Semiconductor Nanostructures

Q Nano Carbon Materials—1D to 3D

R Harsh Environment Sensing—Functional Nanomaterials

and Nanocomposites, Materials for Associated Packaging

and Electrical Components and Applications

MECHANICAL BEHAVIOR AND FAILURE OF MATERIALS

S Mechanical Behavior at the Nanoscale

T Strength and Failure at the Micro- and Nanoscale—

From Fundamentals to Applications

U Microstructure Evolution and Mechanical Properties

in Interface-Dominated Metallic Materials

V Gradient and Laminate Materials

W Materials under Extreme Environments (MuEE)

Y Shape Programmable Materials

ELECTRONICS AND PHOTONICS

Z Molecularly Ordered Organic and Polymer Semiconductors—

Fundamentals and Devices

AA Organic Semiconductors—Surface, Interface and Bulk Doping

BB Innovative Fabrication and Processing Methods for Organic

and Hybrid Electronics

CC Organic Bioelectronics—

From Biosensing Platforms to Implantable Nanodevices

DD Diamond Electronics, Sensors and Biotechnology—

Fundamentals to Applications

EE Beyond Graphene—2D Materials and Their Applications

FF Integration of Functional Oxides with Semiconductors

GG Emerging Materials and Platforms for Optoelectronics

HH Optical Metamaterials—

From New Plasmonic Materials to Metasurface Devices

II Phonon Transport, Interactions and Manipulations

in Nanoscale Materials and Devices—Fundamentals and Applications

JJ Multiferroics and Magnetoelectrics

KK Materials and Technology for Non-Volatile Memories

2015 FALL MEETING & EXHIBIT

November 29 – December 4, 2015 | Boston, Massachusetts

www.mrs.org/fall2015

The MRS/E-MRS Bilateral Conference on Energy will be comprised

of the energy-related symposia at the 2015 MRS Fall Meeting.

A SMART CHOICE FORGENOME ENGINEERING

These days, it seems like CRISPR/Cas9 is everywhere. A simple yet powerful technology, CRISPR/Cas9 is already

changing theway researchers are doing biology, and thework is only just beginning. But how can you quickly and

easily apply this technology to your research? System Biosciences (SBI) has been providing CRISPR/Cas9 systems

longer than any other commercial vendor, giving us an edge when it comes to direct experience with this

game-changing technology. Because experiencematters, your best choice for CRISPR/Cas9 services is SBI.

From the same experts who created our peer-reviewed Cas9 SmartNuclease & OnTarget HR Donor systems, SBI

ofers a full range of genome engineering services, all performed on-site at our state-of-the-art facility inMountain

View, CA to ensure the highest quality, confdentiality and timeliness of delivery.

Services include:

• Guide RNA design and cloning

• HR donor design and cloning for

knock-out, knock-in, tagging & editing

• Cell line engineering and validation

RelativemiR-21(fold)

0.0001

0.001

0.01

0.1

1

Vector

KO#1

KO#2

KO#3

KO#4

KO#5

Ho, TT, et al. Targeting non-coding RNAs with the CRISPR/Cas9 system

in human cell lines. Nucleic Acids Res. 2015 Feb 18; 43(3):e17.

miR-21 knock-out clones

generated by SBI

ComprehensiveCRISPR/Cas9GenomeEngineering Services

FIND OUTMORE:www.systembio.com/cas9-services