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Why Study Neuroscience?Neuroscience: study of the nervous system
physical structure and physical processes
1. Scientific interest – how to get a complete picture Thoughts algorithms neurons molceules
2. Test psychology/linguistics theories Example: visual buffer idea, test what is active in brain Example: test for existence of language module
3. Find out something about cognitive architecture Capabilities of a proposed architecture depend on physical structure Knowing structure/processes should give an idea of architecture
4. Important to understand relationship:physical structure information processing capabilities
Improve treatments for damage (accident or disease) Know human limits
Better learning methods Better computer systems to support humans (compensate for weakness)
Study at Different Scales
1m – CNS
10cm – systems (vision system)
1cm – maps (don’t know much about this)
1mm – networks (don’t know much about this)
100m – synapses (know a bit about this)
1Å – molecules (neurotransmitters)
Cerebrum
Cerebellum
Brain stem
Compare Brains of Other Animals Human similar to rat or monkey Early research tried to find special neural cells which
were unique to humans Didn’t find any
…But human brain bigger Seems not special cells,
but more of them and more connections
Animal Encephalization quotient
Man 7.4–7.8
Bottlenose dolphin 5.3
Chimpanzee 2.2–2.5
Whales 1.8
Gorilla 1.5–1.8
Fox 1.6
African elephant 1.3
Dog 1.2
Squirrel 1.1
Cat 1.0
Horse 0.9
Sheep 0.8
Mouse 0.5
Rabbit 0.4
Brain Development Macaque monkeys born with 60% of brain size Chimpanzee – 46% Human – 25%...
Brain growth rate of foetus same… but… Human brain continues growth at rapid fetal rate for 2 yrs
Child has higher density of connections Gradually eliminated Reach adult values by about 10yrs
Windows for development 8 months can distinguish two foreign language sounds 12 months cannot Strabismus can be corrected in early years Infants born without callosum compensate (other pathways?)
Brain Development Plasticity of brain in children
Language impairment produced by brain injurycan recover if before age 5
Infants who had left half brain removedmany linguistic functions normal
Synapses
Repeated stimulation can increase synaptic strengths For days or even weeks Learning?
Release neurotransmitter chemicals Excitatory Inhibitory
Neurochemical Systems At least 40 different substances Serve a multitude of different functions 2 types
Neurotransmitter act in synapse
Neuromodulator Act more globally … but extremely specific functions Nanogram of angiotensin II : intense and prolonged drinking Acts as trigger
Neurochemical Systems Psychoactive drugs
Mimic/enhance/disrupt effects of body’s neurochemicals
Molecular structures may resemble neurotransmitters LSD similar to seratonin Mescaline similar to dopamine Cocaine blocks reuptake of neurotransmitter
More neurotransmitter remains in synapse to stimulate further
Fascinating Brain Facts… 100,000,000,000 = 1011 neurons
100 000 are irretrievably lost each day
Number of Synapses about 1014 – or a bit more Each neuron connects to 10,000 -150,000 others Every person on planet make 200 000 phone calls
same number of connections as in a single human brain in a day
Grey part folded to fit - would cover surface of office desk The gray cells occupy only 5% of our brains
95% is taken up by the communication network between them
About 2x105km of wiring Pulses travel at more than 400 km/h (250 mph) 2% of body weight… but consumes 20% of oxygen All the time! Even when sleeping Any loss of oxygen… cells die in minutes…
Damage permanent in adults
Mapping Functions to Brain Areas See what disabilities result from specific physical
damage In humans wait for accident In animals do damage deliberately
To see where axons terminate Inject dye, transported along axon Slice up brain and examine under microscope
Insert microelectrodes Into a single neuron Monitor changes in electrical potential
Brain imaging While patient is doing a particular task
Imaging Positron Emission Tomography (PET)
Inject radioactive glucose Gets absorbed by active regions Get the subject to do a task for about two minutes Record image
Functional magnetic resonance imaging (fMRI) Hemoglobin: metalloprotein red blood cells Carries oxygen Hemoglobin diamagnetic when oxygenated
paramagnetic when deoxygenated
More Brain Facts…In right-handed individuals (91% of people)Right side of the brain controls:
musical talent, fantasy, imagination, dreams, drawing and painting.
Left side of the brain controls: mathematical ability, ability to solve logic problems, language skills, remembers names, dates, and facts
Maps change with experience Microelectrodes to map monkey’s hand and fingers area Trained monkey rotating disk for food reward After 20 weeks… Brain area for hand had expanded markedly
Mapping Functions to Brain Areas
Innate or Learned? Nature or Nurture? Major neural pathways very similar in all mammals
Suggests genetic hardwiring
Study of eye in water flea Made cloned insects (genetically identical) Studied neurons Same number of sensory neurons,
and connect to same number of cells Different number of synapses,
and shape of axons
Similar results for pigeons Final system could be quite different in cloned animals
Neuropsychology Tries to discover relationships between
Neuroscience and Psychology …or between : Cognitive models of information processing And structures and processes in the brain
Examples: Study functions of people who have suffered brain damage Build an artificial neural network to solve some problem
(In a biologically plausible way) Then damage the network Study the results and compare with real patients
Imaging techniques (as discussed before)
Neuropsychology studying Alexia Alexia: damage to brain causes loss of ability to read
Ability to read and write can be affected, while speech is normal
Theoretical model of reading: dual route(parallel processing) Lexical route – retrieve words from a lexicon Phonological route – sound out words
Neuropsychology studying Alexia Phonological route
Group word into syllables (by vowels/consonants) Convert syllables to proper phonemes Evident in children sounding words Some patients have difficulty pronouncing unfamiliar words Example: non-words like “troat” Otherwise no problem reading “Phonological deficit hypothesis”
Lexical route Identify base root: antiabortion anti-abort-ion Access Lexical memory to recall proper pronunciation of parts Some patients have difficulty accessing lexicon Must pronounce out word Difficulty with exceptions: yacht, come, have “Dyseidetic” or “visual dyslexia”
Neuropsychology is Difficult Usually have a dodgy cognitive model of a process Must find a match between this and multiple possible brain
implementations Evidence from patients who have suffered damage difficult…
Damage can affect many areas Patients often on medication with not entirely clear effects Patients “grouped” together with “same” damage often different Example: Trauma and tumour quite different Imaging Scans have limited accuracy Patient’s age very relevant
One solution: case study with individuals
Relationship With Artificial Neural Networks ANN typically leave out many aspects of real networks
Real neurons generate sequences of action potentials Frequency and phase significant (ANN has a simple number output) Real networks have multiple neurotransmitters Many distinct types of neurons with different shapes (ANN has one type) Real networks have microcircuits Compute complex nonlinear functions (ANN usually a sum) Maybe synapse should be unit rather than neuron
Some success: trained a network to recognise object position relative to eye direction Used hidden layer in ANN Resulting values closely resembled measurements from macaque
monkey neurons