What is this?

What can it be used

for?

How do we inherit disease?Objectives

Explore the inheritance of genetic disease in particular

with reference to cystic fibrosis and Huntington’s

disease.

Outcomes

3: Outline the causes and symptoms of some genetic

diseases.

5: Explain the inheritance of genetic diseases.

7: Evaluate the social and economic impact on people

diagnosed with genetic diseases, including the benefits

and drawbacks of screening.

Key terms: Genetic, inherited, disease, screening.

Many genetic diseases in humans are a result of recessive alleles of autosomal (sex) genes. Although some are due to dominant or co-

dominant alleles.

• Autosomal recessive: Tay -sachs, cystic fibrosis, Medium-chain acyl-CoA dehydrogenase deficiency (MCADD).

• Dominant: Marfan syndrome, Autosomal dominant polycystic kidney disease, huntington’s.

• Co-dominant: sickle cell anaemia (mild unless two recessive alleles, but will infer malaria resistance)

Outcomes

3: Outline the causes and

symptoms of some genetic

diseases.

5: Explain the inheritance of

genetic diseases.

7: Evaluate the social and economic impact on

people diagnosed with

genetic diseases,

including the benefits and drawbacks of

screening.

Key terms: Genetic, inherited, disease, screening.

How do we inherit disease?

Task

In groups you are going to put together a presentation a genetic disease (cystic fibrosis or

Huntington’s) and deliver it at the end of the lesson

This should cover:

Symptoms

How the disease is inherited

A pedigree chart to show the inheritance

Outcomes

3: Outline the causes and

symptoms of some genetic

diseases.

5: Explain the inheritance of

genetic diseases.

7: Evaluate the social and economic impact on

people diagnosed with

genetic diseases,

including the benefits and drawbacks of

screening.

Key terms: Genetic, inherited, disease, screening.

How do we inherit disease?