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What do grants have to do with it?
Why write a fellowship proposal and how
Alison K. Hall, Ph.D.
Case School of Medicine
Office of Graduate Education
http://casemed.case.edu/gradprog/
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Graduate Fellowship Proposal
why write one?
where does this fit in my career?mechanisms just for MD-PhDs
what is a fellowship proposal anyway?NIH, AHA, others
how do you write a proposal?
Why do you want to write a fellowship?
1. Makes the relationship with the PI explicit
2. Benefits associated with grant
3. Looks good on your resume
4. Great learning experience
5. Stipend bonus
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http://grants.nih.gov/grants/partners/NexusImages/September06/submit.jpg
– http://grants.nih.gov/grants/funding/funding_program.htm – Refers to the kind of research activity that can be funded
• F series Fellowships• K series Career awards• P series Program projects and centers• R series Research projects• T series Training programs
– Not all institutes support all funding mechanisms
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Where does this fit in my career?
Copyright restrictions may apply.
Dickler, H. B. et al. JAMA 2007;297:2496-2501.
First-Time Applicants for R01 Grants by Degree (1964-2004) and Percentage Awarded (1964-2003)
# physician investigators applying for first R01s
little change for 3 decadesThose proposing clinical work less successful
MD-PhDs are few, but successful!
NIH Funding Mechanisms
• National Research Service Awards (NRSA)– F30 Predoctoral Awards for MD/PhD Fellowships– F31 Predoctoral Fellowships– F32 Postdoctoral Fellowships
• K Awards– K01 Mentored Research Scientist Development
Awd– K08 Mentored Clinical Scientist Development
Award– K23 Mentored Patient-Oriented Research
Career Development Award– K99/00 Pathway to Independence Award
5F30DC007274-03 BALU, RAMANIIntrinsic properties of olfactory bulb mitral cells
5F30NS050913-03 COWAN, THOMASAssistive Device Control With Brain Surface Signals
1F30AG029687-01A1 GALLOGLY, MOLLYRole of GRx in calcium homeostasis in the aging heart
1F30NS057883-01A1 MUKERJI, SHIBANIActivin in cerebral hypoxia and acute focal ischemia
5F31NR008984-02 DIMARCO, MARGUERITEAccess/Utilization of Dental Care by Homeless Children
1F31HL085939-01 FLEMING, CHRISTINE3D functional and structural imaging of cardiac tissue
5F31HD049326-03 JAGODNIK, KATHLEENUpper Extremity Control Using Reinforcement Learning
1F31CA123642-01 MONTANEZ-WISCOVICH, MARJORIEMinority Predoctoral Fellowship Program
1F31NS057867-01A1 REED-GEAGHAN, ERINCD14 and TLRs in Abeta-Induced Microglial Signaling
Pre-Doctoral NIH Fellowships at Case
National Research Service Awards for Individual Predoctoral MD/PhD Fellows (F30)
National Institute on AgingNational Institute on Alcohol Abuse and Alcoholism National Institute on Deafness and Other Communication Disorders National Institute on Drug AbuseNational Institute of Environmental Health Sciences National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Diabetes and Digestive and Kidney Diseases
(not all NIH Institutes!)
April 8, August 8, December 8
Transition to electronic submission “on hold”
PHS 416-1 (paper)
$20,772 plus $4,200 include health insurance, tuition!
The F30to promising applicants with the potential to become productive, independent, highly trained physician-scientists in their scientific mission areas
http://grants.nih.gov/grants/guide/pa-files/PA-05-151.html
What about Foundations?
How do you find the right match? Grantsnet.org
Public Charitable Organization
MDA, AHA, ACSSupport from the public
FoundationPrivate, support from a family or corporation
American Heart Association
Ohio Valley Affiliate
Predoctoral Fellowshipinitiate careers in cardiovascular and stroke researchJanuary deadline
Annual Award Amount $21,000: $20,000 stipend plus $1,000 for health insurance
Award Duration One or two years, renew for thirdhttp://www.americanheart.org
Write for the Reviewers
• Reviewers are:– Smart– Accomplished– Dedicated– Fair
Phyllis McBride, [email protected]
Write for the Reviewers
• Reviewers are also:– Busy– Overworked– Skeptical– May not be as
knowledgeable about the details of the proposed topic as the PI is
Phyllis McBride, [email protected]
After your grant is submitted…The NIH review process
Center for Scientific ReviewAssigned to a scientific Review Group (SRG/study section)Scientific Review Administrator
or Training Director (your friend)Study section meets
F’s are scoredSummary Statement
Funding!
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Inside the NIH Grant Review Process
39 min video NIH Center for Scientific Review
Includes R01/K08/ R03
Download proposals
http://www.drg.nih.gov/Video/video.asp#docs
View the video on the web
http://www.drg.nih.gov/Video/Video.asp
What’s in the NRSA?Form pages
including UG, grad grades, MCAT, USMLEBiosketchesResearch Training Plan 10 pages (a-d)
a. specific aimsb. background and significancec. preliminary studiesd. research design and methodse. human subjectsf. vertebrate animalsg. literature cited
Your career and training goalsMentor’s career development plan for you*3 sealed letters of reference
Where to start?
Read the instructions.
Again.
Ask for advice in time to learn
a research question,
specific aims,
hypotheses,
and long-term research goals.
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A strong research idea should pass the “so what” test. What is the benefit of answering your question? Who will it help and how?
If you cannot make a definitive statement about the purpose of your research, it is unlikely to be funded.
The Research Idea
Strong hypotheses:
• Give insight into a research question
• Are testable and measurable by the proposed experiments
• Spring logically from the experience of the lab and you
Make sure you:• Provide a rationale—where did hypotheses they come from,
and why are they strong?• Provide alternative possibilities that could be tested
why did you choose the ones you did over others
Good hypotheses will lead into your Specific Aims.
Specific aims steps you are going to take to test your hypotheses what you want to accomplish in the course of the grant period
Make sure: Your objectives are measurable and highly focusedEach hypothesis is matched with a specific aimThe aims are feasible in technique, time and money
http://www.theresearchassistant.com/tutorial/2-1.asp
Pilot dataFor F30, perhaps a year of work?
The goal of this section is to demonstrate experience and competence to perform the proposed project
Often, the feasibility of your proposed study is demonstrated through the report of pilot data
Can include work of others in lab
Try your hardest to collect pilot data, even if your N is small.
Do not give up!!
You want to earn supportYour mentor wants you to earn supportYour study section wants you to earn support
Pay attention to the summary statement
resubmit
Grantwriting Resources
ScienceCareers.orgCareer Development Articles
NIMH Grant Application Processhttp://www.nimh.nih.gov/researchFunding/grantprocess.cfmhttp://www.nimh.nih.gov/researchFunding/training.cfm
FASEB Grantsmanship Training Programhttps://ns2.faseb.org/careerutilities/grantprg.htm
Grant Application Writer’s Handbook, Reif-Lehrer
See also http://casemed.case.edu/gradprog/Graduate study/grants