! i

:~i!ii

What cheek! Of all research animals, only hamsters have removable cheek pouches. Indispensable

grab bags for the researcher. These poucheS are privileged sites. When the animal is anesthetized, the pouch can be

temporarily removed through the mouth (still at tached)-and later returned to the hamster. The accessibility of this transparent area makes possible the microscopic study of living tissue. Such microcirculation studies as the effect of drugs on the bloodstream. Or any pharmacological investigation. And because the pouch area has almost no immune response, tissue transplants and tumor studies relating to cancer research are aided still further.

Our Lakeview hamsters (golden, cream and albino) are raised under the proven breeding techniques we've developed since 1949. If you'd like more information on our cheeky hamsters, just call, write or order. And pick a pocket or twol

Lakeview Hamster Colony P.O. Box 85, Newfield, New Jersey 08344, (609) 691-2786

A Charles River Company

Fetal Calf

Sharp Clear

Accurate QUANTITATION

WITH cappel !!!

RADIAL IMMUNODIFFUSION READER

I M M U N O D I F F U S I O N KITS . . . . $55 .00 each

72 DETERMINATIONS OF . . . . . . . Human or Human

IgA IgD

or Human IgG or Human IgM or Human IgA (Pediatric) or Human IgG (Pediatric) or Human IgM (Pediatric)

P R O F I L E K IT . . . . $55 .00

18 DETERMINATIONS EACH OF: Human IgA Human IgD Human IgG Human IgM

STANDARD CURVE INCLUDED WITH EACH KIT

IMMUNODIFFUSION PLATES AVAILABLE FOR OTHER PROTEINS AND OTHER SPECIES.

Specialists in Fluorescein, Rhodamine, Ferr i t in and other chemical conjugations.

c a p p e l l a b o r a t o r i e s , inc. O O W N I N G T O W N , P A . 1 9 3 3 5 , U . S . A .

phone: (215) 269-0275 (215) 269-0500

Bio/Physics Systems proudly announces: two exciting new instruments for automatically measuring, differentiating, counting, and characterizing individual cells, cell constituents or particles.

The Cytosraf and Cytof]uorosraf are the subiect ot pendin~ patenta.

These new instruments represent the successful culmination of years of research devoted to replacing the complex, tedious, and t ime-consuming methods of ordinary optical microscopy with what is, in essence, "automat ic microscopy."

These automatic devices very rapidly measure and display mult iple photometr ic propert ies of individual cells f lowing in a l iquid suspension. As a result, conventional manual procedures usually requiring minutes--or hours--can actual ly be accomplished in seconds.

Now, since the implicat ions and appl icabi l i ty of this new technology are enormous and will inevitably challenge the ingenuity of researchers in many fields, we propose a dialog. Begin by reading the brief descript ion of these two instruments below and then ask us for detai led information. After famil iarizing yourself with the impressive capabil i t ies of these devices, instruct us as to your wishes. Would you like to see an instrument in act ion? Would you like to attend one of our Workshop

sessions? Would you like to submit Samples to our Appl icat ions Laborator ies? We'll work with you in any way you prefer. Begin here. The Cytogra f '~

This instrument has two major capabil i t ies: (1) It can distinguish between stained and unstained cells in many procedures involving cells that take up blue or green stains (e.g., in v iabi l i ty analysis, tissue culture studies). (2) It can size a wide variety of cells or particles within the 1 to 100 micron range. The Cyto f luorogra f "

This instrument can characterize and differentiate cells based on scatter measurements, scatter and fluorescence of cells stained with a fluorescent dye, or two wavelength f luorescent emissions from a metachromatic fluorescent dye. (Typical appl icat ions: mass consti tuent analysis, vital stain analysis.)

Now if your work involves the capabil i t ies described above--or logical extensions of them--a dialog may well be mutual ly beneficial. Your turn:

Write Bio/Physics Systems, Inc., Baldwin Place Rd., R ~ l r ~ l A s l n P I = P = h t V lnKNK n r P n m n l ~ f = P ~ J J n ~ n

B I O / P H Y S I C S S Y S T E M S , I N C .

I Bio/Physlcs Systems, Inc., Baldwin Place Rd., Baldwin Place, N.Y. 10505 I I [ ] I am interested [ ] I am interested in [ ] Please send I in the Cytograf. the Cytofluorograf. detailed information.

I My application(s) I I

Name Title

Dept. Organization

Address

zip Phone

area number

THE JOURNAL OF IMMUNOLOGY

BIOLOGY OF TH E I M M U N E R E S P O N S E

Edited by Peter Abramoff, Marquette University

and Mariano F. La Via, The Bowman Gray School of Medicine

1970, 492 pages, $12.95

Biology of the Immune Response fills the gap which exists in immunology today.

While interest in immunology has grown at a rapid rate, until now there has

been no book which presented factual information on immunological problems

at a basic level and in a comprehensive manner. This book deals with the

fundamental aspects of immunology at the cellular as well as the molecular

level. I t is biologically oriented. The up-to-date coverage of present literature

and factual information makes this book a valuable asset to all those interested

in immunology, physiology, pathology, genetics, and related fields.

An outstanding feature of the text is its unified approach. In addition to the

two principal authors, there are eleven contributing authors, each writing in

his area of specialization. These authorities have worked in conjunction with Dr. Abramoff and Dr. La Via to provide an integrated, well-organized, and

unified text. The unevenness of style and approach characteristic of many

multi-authored works has been eliminated.

McGraw-Hill Book Company 3 3 0 W. 42nd St. New York, New York 1 0 0 3 6

A

to meet the needs of all your students!

THE JOURNAL OF IMMUNOLOGY

coherent new text tailored Help us to

serve you b e t t e r . . . . .

A New Book!

T E X T B O O R OF I M M U N O L O G Y

An Introduction to Immunochemistry and Immunobiology

This well-balanced new text can help you meet the demands of the broadest range of student interests and levels of knowledge! Effectively correlating current information, modern terminology, and clear illustra- tions, it describes the varied aspects of im- munology in a concise and intelligible manner. Sections on chemistry of the im- munoglobulins and immunochemistry are complemented by sections on the phylo- geny of the immune response and cellular aspects of the immunoglobulin response. A similar balance is maintained in other discussions, making this new text much more than a catalog of immune responses/ The carefully chosen references stress re- view series which provide a broad base of additional readings. Give this useful book a place in your teaching plans! Fig. 8-5. An electron micrograph of bacteria within a phagocytic cell which has now become rather agranular because of extensive phagolysome forma- tion. (Courtesy D. Senhauser and E. Adelstein.)

By JAMES 1". BARRETT, Ph.D., Professor of Microbiology, University of Missouri School of Medicine, Columbia, Mo. November, 1970. 324 pages plus FM I-X, 7 ~' x 10 'r, 185 illustrations. Price, $10.50.

MO_C, B Y T I M E S M I R R O R

THE C. V. MOSBY COMPANY t lB30 WESTLINE INDUSTRIAL DRIVE

ST. LOUIS, MISSOURI 63141

USE YOUR ZIP C O D E

Remember, your zip code provides faster, mope direct delivery of your journals. Use it on all correspondence, too.

ANNOUNCEMENT

SURVEY COURSE IN IMMUNOLOGY

The Annual Survey Course in Immunology, sponsored by the American Association of Im- munologists and supported by a Training Grant to the University of California from the National Institute of Allergy and Infectious Diseases, will be held at the University of California at San Diego (UCSD) in La Jolla, California, July 19 through July 30, 1971.

The course is intended primarily for univer- sity or college instructors. The number to be se- lected will be limited to approximately 50. Selec- tion will be on a competitive basis and decided by the Committee on Admissions.

Applicants should submit a letter to Howard M. Grey, M.D.~ Division of Allergy and Clinical Immunology, National Jewish Hospital and Re- search Center, Denver, Colorado 80206, not later than April 1, 1971. The letter should be accom- panied with the following information and supplied in quadruplicate: 1) curriculum vitae, 2) current research and teaching activities, 3) reasons for wanting to enroll in the course, and 4) background in immunology.

There are no formal application blanks. A $100 registration fee will be charged. Per diem costs at the University are approximately $10

Normal EBTR cells stained with H & E IBR isolate in EBTR cells stained with H & E

a growing problem A number of lots of commercially prepared fetal calf sera have been shown to contain viable viral agents.l,2,3 The presence of these agents could result in misleading test results or viral contamination of normal cell populations.

BBL routinely tests all lots of Calf and fetal calf sera to ensure the absence of bovine cytopathogenic agents. There is no charge for this service.

This new test procedure, coupled with BBL's quality control procedures, including: cell growth efficiency, sterility, immunoelectrophoretic evaluation, and evaluation for total protein content, provi