• What are the greatest challenges facing our region, state, nation, and world?

• What does it take to address them?

• Who can help the majority of global citizens, including those locally and nationally, who lack access to fundamental resources?

• What is our role?

The Challenge

INNOVATION PROCESS

INNOVATION PROCESS

INNOVATION PROCESS

INNOVATION PROCESS

Three Translational Methods• Launch innovators into the world.

• Persuade.

• Create social and commercial ventures

Five Recommendations

Prepare faculty, graduate and undergraduate students, staff, and the broader Carolina community with the knowledge, skills, and connections necessary to translate new ideas into innovations.

• Goal 1.2 Build capacity for innovation.– Action 1.2.1 Provide educational opportunities about innovation.

• Build on successful existing programs– The Minor in Entrepreneurship– The Chancellor’s Faculty Entrepreneurship Boot Camp– First Year Seminars– Launching the Venture– Carolina Challenge

– Action 1.2.3 Create Student Innovation Hub

Example

Collaborate with diverse groups on campus and beyond to explore issues, options, and creative approaches that may lead to innovations.

• Goal 2.1 Enhance robust interdisciplinary collaboration– Action 2.1.1 Set as a top priority advancing applied sciences

• 5 Applied Sciences Distinguished Professorships

• Goal 2.2 Collaborate, coordinate around key themes of local, national, and global significance– Action 2.2.1 Create the Key Themes Initiative

Examples

Translate important new ideas more expediently and at an increased volume into innovations that improve society.

• Goal 3.1 Advance social entrepreneurship– Action 3.1.1 Refine and develop an integrated campuswide approach

• Goal 3.2 Optimize the university’s commercialization output– Action 3.2.1 Expand the Entrepreneurs-In-Residence program

• 18 EIRS throughout the campus

Examples

Align people, incentives, resources, and processes to strengthen an intentional culture of innovation at Carolina.

• Goal 4.2 Recruit, retain, and reward faculty, students, and staff who show promise, aptitude, and/or achievement in innovation

– Action 4.2.1 Recruit innovators and future innovators

– Action 4.2.2 Reward activities that contribute to the culture of innovation at Carolina• Create two Innovation Professorships

• Goal 4.4 Provide funds to support nascent and promising innovations on campus

– Action 4.4.1 Establish the Carolina Innovation Fund

Examples

Catalyze innovation at Carolina by facilitating the work of faculty, staff, and students as they put important ideas to use for a better world.

• Goal 5.1 Leverage the talents of leaders across campus to prepare, collaborate, translate, and align resources and processes to strengthen the culture of innovation at Carolina– Action 5.1.1 Create management groups of program leaders from

across the campus

• Goal 5.2 Create the Chancellor’s Catalyze Group to facilitate the implementation of this Roadmap– Action 5.5.2 Help raise funds and manage the single source gateway to

innovation to ensure faculty, students, and staff are aware of available resources and opportunities for innovation.

Examples

• Career Services: Gary Miller, new title, includes innovation. Now hosting the CSIT meetings, opening an incubator on Hanes fourth floor called H4 for this summer. Working on the Navigating concept using their technology.

• Medical School: Appointed Cam Patterson as Associate Dean of Medical Entrepreneurship. Moved TRACS Carolina Kickstart reporting to him. Exploring how the medical and business schools could work together to do innovative work.

• Biomedical engineering – Nancy Allbritton, faculty entrepreneur – joint program with NC State. Integrating graduate and undergraduate. Important step for Applied Sciences.

• Entrepreneur-in-Residence: Expanding and improving. Regular Meetings.

Rethinking & New Programs

• Carolina Kickstart – reinventing itself to better serve startups in the sciences. Building two new funds: Carolina Catalyst (evergreen loan pool, $25K-$75K) and Carolina Capital (seed fund); Carolina Entrepreneur Network of alums.

• IAH – new $100,000 award for Faculty Innovation Grants.• Innovation Scholars – first one this year, four more for next year.

4-year full scholarship.• Dean’s Innovation Fund in Journalism from Innovation Circle

member.• Campus Y – strategic planning to strengthen it social innovation

work.• Buck Goldstein working with IAH to host a series of seminars on

the co-authored book with Holden Thorp: Engines of Innovation.

Rethinking & New Programs

• Students: CSIT just elected their new leader, Hudson Vincent. Working on Digital Navigator. Student Innovation Fair in April.

• Speaker Series: Desh Deshpande, Steve Case, Cheryl Dorsey. Bob Langer MIT

• Global Education Center and School of Public Health working on Entrepreneur-in-residence program about big challenges. Water conference huge success.

• First Year Seminars: Revupinnovation.com• The Minor in Entrepreneurship in the College of Arts and

Sciences, academic committee, getting closer to endowment goal.

• University Entrepreneur-in-Residence, received endowment for position.

• Grant from Blackstone Charitable Foundation for entrepreneurial development in the Triangle. Brought in Duke, NC State, NC Central, CED as partners.

Rethinking & New Programs

National CTSA & TraCS Goals• To improve how biomedical research is conducted

across the country• To reduce the time it takes for laboratory discoveries

to become treatments for patients• To engage communities in clinical research efforts• To train the next generation of clinical and

translational researchers

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About TraCS• North Carolina Translational and Clinical Sciences

(NC TraCS) Institute • Home of the NIH CTSA – Clinical and Translational

Sciences Award• 1 of 55 CTSA institutions ; 60 total expected• Infrastructure grant; Funded May ’08• ~ 260 faculty/staff involved in 15 cores and

programs and 59 specific aims, serving over 2,000 members across the state

• Home on 2nd floor of Brinkhous-Bullitt Bldg.

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NC TraCS Activities Throughout North Carolina Counties

NC TraCS Activities has spanned across 68 of the 100 NC Counties

Javacia C. Jackson

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NC TraCS Academic Partners• Academic Partners

• Duke University• Durham Technical Community College• East Carolina University• NC Agricultural and Technical University• NC Central University• UNC Charlotte• NC State University

• Activities with Partners vary:• Faculty at UNC and partner schools collaborate; partners

match $50K program; share resources and educational activities

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NC TraCS Community Partners

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American Indian Mothers, Inc. Area L Health Education Center Carolinas Medical Center Charlotte Area Health Education Center Communities in Schools of Orange County, Inc. Community Care Networks of North Carolina Duke Primary Care Research Network Durham Committee on the Affairs of Black People Durham County Health Department Eastern Carolina Association for Research and Education El Centro Latino Family Support Network of North Carolina GlaxoSmithKline Greensboro Area Health Education Center The Hamner Institute for Health Sciences Healthy Carolinians IBM Levine Children’s Hospital McNeil Consumer Healthcare Mecklenburg Area Partnership for Primary Care Research

Mid Carolina Cardiology Moses Cone Health System National Institute of Environmental Health Sciences (NIEHS) New Hanover Medical Center North Carolina Biotechnology Center North Carolina Coalition Against Domestic Violence North Carolina Dept Health & Human Services/Division Public

Health North Carolina Family Medicine Research Network North Carolina Healthcare Information and Communications

Alliance (NCHICA) North Carolina Institute of Medicine NC Multi Site Adolescent Research Consortium for Health North Carolina Research Campus, Kannapolis, NC Quintiles Transnational Corp. Renaissance Computing Institute (RENCI) Research Triangle Institute Robeson County Primary Care Research Network SAS SouthEast Area Health Education Center Wake Area Health Education Center

SouthEastern CTSA Consortium (SECC)

• Eight CTSAs: Duke, Emory, MUSC, UNC, UAB, U Arkansas, U Florida, Vanderbilt

• First Meeting early 2010• Current activity:

– Emory, Duke and UNC are moving forward on a project to share electronic medical record data for clinical research; comparative effectiveness research on hypertension across the south east. We intend to seek funding for this project.

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TraCS Cores and Programs

Biomedical InformaticsBiostatisticsClinical & Community DisseminationCommunity EngagementCommercializationClinical Data ManagementClinical & Translational

Research Center Clinical Dental & Inflammation

Research

EducationGovernanceGrant Proposal Assistance Novel MethodologiesPilot Grant ProgramRecruitmentRegulatoryResearch EthicsStrategic OpportunitiesTranslational TechnologiesTraCS Central

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TraC$2K Web form submitted from TraCS website

Deadlines every month

TraC$10K Application submitted via email to TraCS; 5 page research plan

Quarterly deadlines; March, June, Sept and December

TraC$50K*(*=requires 50/50 match)

Application submitted via email to TraCS; 5 page research plan

Deadlines 3x/year;Jan, April & Aug

Total of 515 unique investigators funded since January 2009255 of 707 applications submitted were funded (36%)

TraCS Offers 3 Levels of General Pilot Funding

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$100K Planning Grants - Aimed at:

• Stimulating UNC-CH investigators to serve as PIs for new centers, roadmap initiatives, and multicenter clinical trials.

• Reducing the barrier for faculty who conceive of large-scale proposals but never move forward because of the daunting process

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Projects outside UNC• 17 funded pilot grants have PIs outside UNC,

including these academic institutions:• East Carolina University• Elizabeth City State University• North Carolina State University• UNC Charlotte

And at community organizations including: • The Hamner Institutes for Health Sciences• Haywood Regional Medical Center• Mecklenburg Area Partnership for Primary

Care Research• WakeMed Health and Hospitals

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Submitted, Funded Pilot Grants by PI/Co-PI, School

School/Unit # funded** # submitted % funded

Arts & Sciences 10 25 40%

Dentistry 9 37 24%

Education 1 2 50%

Information & Library Sciences 1 1 100%

Journalism & Mass Comm 1 3 33%

Medicine 156 438 36%

Nursing 13 23 57%

Pharmacy 24 52 46%

Public Health 32 89 36%

Social Work 3 8 38%

Outside Institutions 10 40 25%

** this total is greater than the total # of awarded grants due to multiple PIs & PIs with joint appointments 28

Preliminary Outcomes - TraCS Pilot Program

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Program External Grants Publications Presentations

$50kgrants awarded32 grants completed 1st grants completed in fall 2010

10 NIH grants and 3 other grants – include R01s (3); R21; U01, K23, NCI GO grant, ARRA2 NIH grant subcontracts, CF Foundation, Pfizer Foundation, Simons Foundation

5 publications:- Diabetes-Hepatology (2 papers)-Journal of Applied Physiology-Pharmacoepidemiology and Drug Safety

34 presentations

$10kgrants awarded61 grants completed1st grants completed in fall 2010

7 NIH grants; 10 other grants – include R01s (3), K23, NHLBI GO grant, NICHD and NCRR grants, Angelman Syndrome Foundation, Johnson & Johnson, Natl Alliance Research on Schizophrenia and Depression, EPA Environ. Justice, UNC-CH Cancer Center grants (2), Orange County, UNC-CH U Research Council (2), SAMSHA

15 publications including:-Journal of Immunology-American Association of Pharmaceutical Scientists (AAPS) Journal-Journal of the International Society on Thrombosis and Haemostasis - Computerized Medical Imaging/ Graphics- Environmental Justice- Intl Jrnl of Computer Assisted Radiol/Surg- Journal of Medicinal Chemistry- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics- Thrombosis Research

75 presentations

$2kgrants awarded55 grants completed1st grants completed spring 2010

3 NIH and 1 other grant - R01,R24, F32, Merck plus assisted with renewal of Program Project grant

13 publications including:- American Journal of Clinical Pathology - American Journal of Obstet & Gynecology- American Journal of Perinatology- American Journal of Respiratory and Critical Care Medicine- International Urogyncological Journal- Journal of Bone and Mineral Research-Osteoarthritis & Cartilage-Drug Disposition

49 presentations

Examples of how NC TraCS is improving research at UNC-CH

• Commercialization – NC KickStart: – Offering assistance to faculty with their commercial start-up

ventures, including access to business experts, education, mentoring, and pilot funding

– Numerous faculty companies assisted to date

• Research Navigation– Four faculty each 49% effort assist investigators develop new

ideas or relate a research question to translational medicine and assist in the development of clinical and translational investigator teams

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Biomedical TranslationBench Bedside

Boardroom

Commercialization

University

University Startup(NewCo)

BiomedicalInnovation

Patent

BusinessConcept

Management Team

Investment

Product Development

License

CommercializationPaths

Established Company(BigCo)

Sponsored Research

Product Development

Product Strategy

CommercialProduct

Mission

Increase the impact of biomedical innovations by fostering and promoting entrepreneurial

commercialization

BackgroundOriginally formed as NC BioStart

• Driven by faculty frustrationWritten into CTSA proposal

• Aim: Mentor faculty in commercialization effortsProgram expanded in last 1.5 years

• Renamed Carolina KickStart• Full-time director• Programs beyond mentoring

Goals of Carolina KickStartEducate faculty and students as to the process and expectations

of commercializing technologies through startups.Mentor faculty and students during the process of

entrepreneurial commercialization.Connect outside resources and talent (entrepreneurs, advisors,

investors, and services providers) with UNC startup opportunities to help facilitate the commercialization process.

Fund technology and venture development by providing internal funding and facilitating external funding (SBIR, investors).

Incubate startup companies by providing suitable space

PersonnelCam Patterson, MD, MBA Executive DirectorDon Rose, PhD DirectorAndrew Kant, MS Assistant DirectorJustin Brown, PhD Technology Scout

John Strenkowski, MBA Business FellowRicky Spero, PhD Technology Fellow

Joel Shaffer, PhD Entrepreneur-in-ResidenceTom Mercolino, PhD Entrepreneur-in-ResidencePerry Genova, PhD Entrepreneur-in-Residence

Biomedical Product

Capital SBIR Grants

AngelsVCs

PeopleFaculty

StudentsEntrepreneurs

Biomedical Innovations

DrugsDevices

Diagnostics

Carolina KickStart

Faculty

OTD

Kenan-Flagler Business School

Entrepreneurs

Investors

Partners

Features of the Program• Webinars• Kenan-Flagler’s Launch the Venture• Founder’s Handbook

Education

• Entrepreneurs-in-Residence• Technology ScoutsMentoring

• Networking events, meetings at coffee shops• Innovation Fellowship Program• Database of entrepreneurs, investors

Connecting

• NC TraCS Pilot Grants• Commercialization Awards• Carolina Investment Group

Funding

• Facility Use Agreements• Off-campus incubation spaceIncubation

KickStart Portfolio CompaniesKatharos—dialysis device for serum phosphateNovoLipid—lipid-modified chemotherapy agentsCortical Metrics —non-invasive brain assessmentHibernaid—pharmacological hypothermiaRheomics—mechanical biology micrcoscopyCell Microsystem —cell isolation and culture deviceEnci Therapeutics —anti-angiogenesis mAb for cancerNeuroGate—therapeutics for neuropathic painKL Medical —minimally invasive portal for heart surgeryVascular Pharma —mAb for reducing diabetes-induced CHDG-Zero—therapies for chemo induced immunosuppressionSynereca—co-therapeutics for potentiating antibioticsQualiber—liposomal drug delivery platformClinical Sensors —NO sensor for early sepsis detectionIronwood Material Science —materials for dental implantsX-in8—therapeutics to reduce organ transplant rejection

What will Holden release at University Day?????

Innovate.unc.edu