E�ective Protection for Liver Problems

Cells exposed to oxygen produce reactive oxygen species (ROS). These ROS are oxygen molecules that have lost an electron and try to retrieve it from neighboring molecules, causing damage at the level of membranes, collagen, enzymatic processes and protein synthesis, leading even to changes and mutations of DNA.

Almost all the causes of liver �brogenesis involve ROS. In certain situations the production of these radicals increases, initiating a process of oxidative stress. Exposure to toxic materials, infectious agents, and even prolonged contact with bile acids in cholestasis processes are the common causes for this increased production of ROS.

The liver is a versatile organ and it is responsible for many functions such as bile and its components’ (bilirubin, bile acids, cholesterol etc.) synthesis and excretion, it is also involved in numerous metabolic pathways like protein synthesis (albumin, proteins of acute phase and clotting factors, etc.), glucose, cholesterol, urea, lipid metabolism and drugs detoxi�cation. Still has an important role as a reservoir of nutrients.

The liver is thereby subject to numerous attacks, either-viral and bacterial processes or by metabolic, in�ammatory, toxic and hereditary processes.

Despite its high regeneration capacity, severe aggression, chronic or repetitive processes can lead to �brosis, and consequently the appearance of non-functional areas.

Liver’s high capacity of regeneration and response causes late manifestation of disease symptoms, when the extension of the injuries is already high.

WePatic® has an antioxidants and protectors key combination to minimize the impact of secondary changes in aggression and liver problems.

LIVERLIVER

OXIDATIVE STRESS DNAPROTEINLIPIDS

WePatic

SAMe (S-ADENOSIL-L-METIONINA)Acts as a precursor molecule of thiols and increases the concentration of glutathione, which is crucial in glutathione-peroxidase’s activity and critical in defense against ROS. WePatic ® uses a gastroenteric coating for a greater bioavailability.

ZINC Extensive hepatoprotective function. It inhibits free oxygen radicals production, protecting sulfhydryl groups from oxidation. Works as copper chelator, helping reducing �brosis. Inhibiting the lipid peroxidation works as a stabilizer of cell membranes.

SELENIUMSelenium is an essential element and a cofactor for glutathione peroxidase, an enzyme needed to reduce the harmful e�ects caused by free oxygen radicals. It also has an e�ect reducing IL-6 transcription and expression.VITAMIN E

Plays a vital role protecting against ROS. Is the most important fat-soluble vitamin in protection complex, along with glutathione and vitamin C. Its combination with selenium helps prevent peroxidases’ action in cell membranes, protecting these last ones from bile acids action in cholestasis situations.

VITAMIN CIt is a water soluble vitamin that acts in the liver mainly as an antioxidant, making the ROS inert.

SILIPHOS (SILYBIN + PHOSPHATIDYL-CHOLIN COMPLEX)Is a source of silybin, highly active and bioavailable for an inhibitory e�ect over free radicals, and antihepato-toxic, helping keeping out harmful agents at a cellular level. Improves liver enzymes’ levels. It stimulates the production of new liver cells as well as improvement of existing survival and histology. Increases protein synthesis. Inhibits the synthesis of in�ammatory leukotrienes, reducing in�ammation and �brosis.

DAMAGED HEPATOCYTES

KUPPFER CELLS

DESTROYED

INFLAMMATORY CELLS

LEUKOTRIENES CYTOQUINES

MACROPHAGES (IN RESPONSE

TO INFECTIOUS AGENTS AND

TOXINS)

MEMBRANOLITIC BILE ACIDS

ROS

E�ective Protection for Liver Problems

WePatic®Hepatoprotector- Tasty Tablets

ANutritional Supplement for small breed dogs and cats developed to improve and give nutritional support to the liver function and in cases of chronic liver failure.

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References:(1) Web, C. Twedt, D. Oxidative stress and liver disease. Vet Clin Small Anim 38 2008; 38: 125-35. (2) Czuczejko J. Selenium, glutathione and glutathione peroxidases in blood of patients with chronic liver diseases. Acta Biochimica Polinica Vol. 50 No. 4/2003 1147–1154. (3) Ettinger S J, Feldman E C: Textbook of Veterinary Internal Medicine, sixtth edition. Section XV, Liver and pancreatic diseases. (4) Wang Y, J Biomed Nanotechnol. In vivo evaluation of silybin nanosuspensions targeting liver. 2012 Oct;8(5):760-9. (5) Vandeweerd, JM., Vet Clin Small Animal Practice. Nutraceutical for canine Liver Decease: Assessing the evidence 43 (2013) 1171-1170. (6) Cynthia RL,. Vet Clin Small Animal Practice. Therapeutic use of citoprotective agents in canine and feline hepatobiliar disease 39 (2009) 631-652. (7) Cabrera, TC Rev Cubana Cardiol. Algunos aspectos sobre el stress oxidativo y la terapia de suplementacion (2000) 14(1):55-60. (8) Skorupski, KA. J Vet Intern Med. Prospective Randomized Clinical Trial Assessing the E�cacy of Denamarin for Prevention of CCNU-Induced Hepatopathy in Tumor-Bearing Dogs (2011) 25:838–845

WePatic®

SAMe (S-Adenosil-L-metionina)Siliphos (Complexo de Silibina + Fosfatidilcolina)Vitamin CVitamin EZincSlenium

Small Breeds and Cats80 mg10 mg15 mg12 mg10 mg6 μg

Medium and Large Breeds300 mg40 mg50 mg30 mg20 mg12 μg

Therapeutic recommendations and doses:Animals up to 5 kg: 1 tablet WePatic® Small Breed Dogs and Cats per day.Animals from 5 to 10kg: 2 tablets WePatic® Small Breed Dogs and Cats per day.Animals from 10 to 20kg: 1 tablet WePatic® Medium and Large Breed per day.Animals from 20 to 30kg: 2 tablets WePatic® Medium and Large Breed per day.Animals from 30 to 40kg: 3 tablets WePatic® Medium and Large Breed per day.Animals over 40kg: 4 tablets WePatic® Medium and Large Breed per day.

Composition per tablet of WePatic®:WePatic

It is recommended to consult a veterinarian before use.This product should not be used as a substitute for a varied diet. Do not exceed recommended dose.Veterinary use only.

Presentations:Small Breeds and Cats - 30 Palatable Tablets in blister packSmall Breeds and Cats - 120 (4x30) Palatable Tablets in blister packMedium and Large Breeds - 30 Palatable Tablets in blister packMedium and Large Breeds - 120 (4x30) Palatable Tablets in blister pack

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Small Breeds and Cats - 120 (4x30) Palatable Tablets in blister packMedium and Large Breeds - 30 Palatable Tablets in blister packMedium and Large Breeds - 120 (4x30) Palatable Tablets in blister pack

- 120 (4x30) Palatable Tablets in blister pack- 30 Palatable Tablets in blister pack- 120 (4x30) Palatable Tablets in blister pack