Welcome to theMolecular Medicine

course!

Registration• General information• Over-arching goals• Roll call• Course contents• Information about KS library• Coffee • Course evaluation HT 2011• Study design

- research application + presentations• Seminar assignment• Final examination• Molecular Medicine - from bed to bench

Course leader: Rachel Fisher08-517 732 45 rachel.fisher@ki.se

Deputy course leader: Ewa Ehrenborg08-517 761 91 ewa.ehrenborg@ki.se

Teaching assistant: Louisa Cheung08-517 732 21 louisa.cheung@ki.se

Department of Medicine, Center for Molecular Medicine,Karolinska University Hospital, L8:02

Course administrator: Eva MacDonaldDepartment of Medicine, Unit for Internal Medicine,Karolinska University Hospital, A3:0208-517 716 33 eva.macdonald@ki.seOffice hours daily 8.00am - 3.00pm

Over-arching goals

• To integrate previously gained knowledge

• To stimulate team work

• To analyse, evaluate and interpret raw data

• To design a study and write a research application

• To provide “real life” experience

Roll call

Course set up

• Lectures usually 9am – 3pm (check venue!)• Labs/demonstrations/seminars usually in groups• Time scheduled for group work• Seminar assignment• Presentation of group work (research application)

at end of course• Revision time• Final written examination: 15th January

Course contents (15 hp/ECTS)

Specific areas• Circulation, ischemia, metabolic syndrome, diabetes • Respiration, asthma, allergy • Endocrinology• Gastroenterology• Pathology• Clinical immunology / Clinical chemistry

Assignments etc.• Molecular biology lab• Research application• Seminar assignment• Workshops• Revision

Course literature

• Text books from previous courses:

physiology, pharmacology, biochemistry,

molecular genetics, immunology

• Articles and links on the web page

• Lecture summary points (from lecturers)

Information about KS libraryMarie Källberg

Lab “Methods in Molecular Biology”

Lectures, demos, labs, exam

Research plan

Seminar assignment

Workshops

Labs and Demonstrations • Lab: “Methods in Molecular Biology –

Theory and Practice”12/11 (introduction)27-29/11, 4-6/12 (lab)12-14/12 (analysis + statistics)9/12 (discussion + review)

• Angiography demonstration (14/11)

• Blood grouping lab (15-16/11)

• Lung/allergy demonstration (20/11)

Labs • You must bring your own lab coat

Compulsory to have a lab coat to perform the labs

• If you have lost the lab coat you were given when you started the Biomedicine Programme, you can buy a new one (380kr):http://www.g-ess.se/ Tel: 08-449 85 70 (Stuvsta + Bromma)

• Some labs and demonstrations will be performed in active research labs- show consideration for those who work there

Groups

• Blood grouping Thur 15/11, 13–16• Methods Mol Biol Tue 4/12

• Blood grouping Fri 16/11, 13–16• Methods Mol Biol Wed 5/12

• Blood grouping Thur 15/11, 9–12• Methods Mol Biol Tue 27/11

• Blood grouping Fri 16/11, 9–12• Methods Mol Biol Wed 28/11

Course evaluation HT 2011Good

• Research application• Lab “Methods in Molecular Biology”• Seminar assignment• Course leaders/administration

Mixed• Clinical emphasis• Blood grouping lab• Lung/asthma/allergy demonstration• Lecturers

Bad• Lack of a course text book• Some repetition within lectures• Too many lectures

New for HT 2012

• Some lectures + pathology seminars removed• Workshops• Modified set up for Lab “Methods in Molecular

Biology”• Place blood grouping lab in context• Modified lung/asthma/allergy demonstration• Final examination after Christmas• Presentation of research applications at end of

course

Workshops • 3 workshops: Atherosclerosis

(12/11)Endocrinology

(21/11)Diabetes/Metabolism

(11/12)

• Questions/discussion topics handed out in connection with relevant lectures

• Self-study/discussion + review with teacher

• Preparation for the exam

Evaluation of the course

• We rely on your feedback to improve the course

• Please give constructive feedback

• Evaluation forms (online)• Cinema ticket voucher if all evaluation forms

completed + submitted!

• With class representativesWednesday 21st November, 12 noon

• With whole classThursday 17th January, 3pm

Who are the class representatives?

Course councils

Forms of feedback

feedforward assignments

Research

application

whole-class feedback

Workshops

Research application

feedback on seminar assignment & exam

Pre-submission guidance and feedback

Research application

Workshops

Peer-to-peer to edit and

redraft

Methods in mol biol

reviewing progress with

students

Informing about feedback

Course councils and evaluations

Round-table feedback

Methods in mol biol

Course language

• All literature in English

• Lectures in English

• All assignments may be written in either

English or Swedish

Research application• Group assignment

• Choose a specific issue to focus on

• Design a research project

• Write a research application

• Present the project orally

• Answer questions

• Team work

• Realistic exercise

Research application:groups and topics

• Groups 1-6 each split in 2

• 12 ”subgroups” of 3-4 people

• Each subgroup allocated a broad topic

• Detailed project chosen by the subgroup

• Discussions with and feed back from topic ”mentor”

Research application – broad topics

• MicroRNA and vascular disease

• Aneurysm

• Thyroid diseases

• Thrombosis and haemostasis

• Mesenchymal stem cells and bone formation

• Cell death in metabolism

• Metabolism and cardiovascular disease

• Immunological aspects of gastric disease

• Inflammation in cardiovascular disease

• Allergy

• Diabetes and co-morbidities

• Vascular remodelling

2 topics/group, 3-4 people/research application

Research applicationtopic lottery

Seminar assignment

• Handed out at course start

• Group work / individual assessment

• Research based aspects, requires independent work

• Obtain appropriate information- lectures, discussions, web, articles ..…

• Time scheduled to prepare answer

• Presentation of assignment in seminar format:Groups 4, 5 + 6 Wednesday 28th NovemberGroups 1, 2 + 3 Wednesday 5th December

• Grading = pass / fail

Time in schedule for Groups 1, 2 + 3to work with seminar assignment

Time in schedule for Groups 4, 5 + 6to work with seminar assignment

Examination

• Final examination: Tuesday 15th January Grades A-F

Questions testing knowledge + understanding

Grading of the examination• F, Fx, E, D, C, B, A

• Goal-based assessment

• Evaluating the level of knowledge obtained not the amount of knowledge

• F, Fx = fail

• E = basic pass: identify, describe, list

• C, D = pass with merit: compare, explain connections, analyse, apply

• B, A = pass with distinction: theorise, hypothesise, reflect

PrestructuralF

UnistructuralFx

MultistructuralE

RelationalC, D

Extended abstractB, A

One relevantaspect

Several relevantindependent aspects

Integrated intoa structure

Generalized tonew domain

To pass the course …

• The student must obtain a grade of at least E for the written examination (5 hp)

• The student must also pass

– the seminar assignment (3 hp)

– the research application (3 hp)

– all labs and demonstrations (4 hp)

Replacement assignments

• When compulsory parts of the course are missed, there are replacement exercises

• If written, these must be handed in by the last day of the course (18 January 2013)

• Next opportunity for submission = next course (HT2013)

• Wednesday 21st November, 1pm

Lars-Arne Haldosén

Lena Hansson

Information about Masters Programme

Molecular Medicine:from bed to bench

• Important clinical contact

• Translational research

• Cross-disciplinary

• “From bench to bed and back again”

Please use the web page!