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WelcomeCharles Kennedy
Comoderators
Girish P. Joshi, MBBS, MD, FFARCIProfessor of Anesthesiology and Pain ManagementUniversity of Texas Southwestern Medical CenterDallas, Texas
David E. Beck, MD, FACSProfessor and ChairDept of Colon and Rectal SurgeryOchsner Clinic FoundationNew Orleans, Louisiana
Professor and ChairOchsner Clinical SchoolUniversity of Queensland School of MedicineAustralia
Summary of Yesterday’s DiscussionsDr Joshi
Explanation of Today’s FormatDr Beck
Review of the Pain Consortium/Congress Concept and Review of History
Dr Joshi
Review Congress Mission and GoalsDr Joshi
Brief Summaries of Research/ExperienceESC
BENEFITS OF A MULTIMODAL
REGIMEN INCLUDING LIPOSOMAL
BUPIVACAINE FOR POSTSURGICAL
PAIN IN COLORECTAL SURGERY
David E. Beck, MD
David A. Margolin, MD
Sheena Farragut Babin, PharmD Christine Theriot Russo, PharmD
Depts Colon & Rectal Surgery & Pharmacy
Ochsner Clinic Foundation
New Orleans, LA
Ochsner Medical Center
• 550 bed, tertiary-care referral center
• Five staff colon rectal surgeons
• Training institution for colon rectal
fellowships
• 800 operative colorectal cases per year
Ochsner Experience
• Retrospective Chart review :
–October 2011 – January 2013
• 179 pts : major colorectal surgery
–81pts : 266 mg liposomal bupivacaine &
multimodality pain management
–98 pts : conventional therapy (PCA)
• T-test and chi square
Ochsner Medical Center Experience
Characteristic Exparel ®
N = 66
Control
N = 167
P
value
Age (avg yrs) 59.8 54.7 ns
Gender (% Male) 39.4% 46.1% ns
Post op Pain Score
(avg)
5.5 6.6 < 0.05
Opioid Free (hrs) 5.2 2.9 < 0.05
Post Op LOS (days) 7.2 9.0 < 0.04
Cumulative Post-Operative
Narcotic Use
0
10
20
30
40
50
60
70
12-Hr 24-Hr 36-Hr 48-Hr 60-Hr 72-Hr
Exparel
Non-Exparel
mg of
morphine
P < 0.0007)
Ochsner Medical Center
Experience
Characteristic Exparel ®
N = 66
Control
N = 167
P
value
ORAE
Anti-pruritic meds
Anti-emetic
Anti-constipation
0.4
2.7
0.6
4.47
6.7
0.9
<0.03
<0.012
<0.05
• Liposomal bupivacaine : 81 pts
• Laparoscopic : 34 pts
• Open procedures : 47 pts
• No difference
– pain medication
– ORAE
Current Management• Pre-Op (Holding)
– Acetaminophen 1000 mg IV
– Ibuprofen 800 mg IV q
• Intra-OP
– Liposomal bupivacaine 266 mg (20 cc)
– Bupivacaine : 0.25% 30 cc (75 mg)
– Saline 20 cc
• Post-op
– Acetaminophen 1000 mg IV q 8 h
– Ibuprofen 800 mg IV q 6 h
– PCA
– Conversion to oral meds
• Care pathways
Conclusion
In Major CR procedures
– Liposomal bupivacaine & Multimodality pain
– Lower pain scores
– Decreased opioid use
– Less ORAE
– Decreased LOS
Clinical Case
Beck, DE18
• JB is a 75-year-old male
• 6 weeks previously had low anterior
resection and loop ileostomy for an early
rectal cancer
• Previous surgery
– Ileus, temporary mental status changes, andurinary retention with narcotics
• Normal contrast study of anastomosis
• Loop ileostomy closure
Loop Ileostomy Closure
Beck, DE19
Loop Ileostomy Closure
(continued)
• Intra-op: EXPAREL® 20 cc infiltrated into wound
20 Beck, DE
Infiltration technique
21
Radial infiltration
Two levels
− Deep
dermal
− Deep tissueBeck, DE
Clinical Case (continued)
22
• Post-op: Acetaminophen 1000 mg IV q 12 hoursIbuprofen 800 mg IV q 12 hours
• POD 2: Bowel movementStopped IV medicationOral hydrocodoneRegular diet
• POD 3: Discharged
• No IV narcotics: Avoided PCA
Beck, DE
Postoperative Pain Management
• Multi-modality
– Analgesics
• Non-opioid
• Opioid
– Exparel
• Reduced pain scores
• Decreased & Delayed OpioidRequirements
• Lowered ORAE
• Reduced Length of Stay
Brief Overview of PROSPECTDr Joshi
Break
Industry’s Role inConsortium Mission
OPEN ForumFacilitator: Dr Beck
Meeting Summary and Wrap UpDr Joshi
Lunch
This program is supported by grants from
Thank you!
Accomplishing Our Long-Term Mission
• Establish a national identity as the benchmarking organization foridentifying, developing and disseminating best practices for managingsurgical pain in the United States
• Act as a repository of surgical pain management educational materials foreducation of healthcare personnel including students and residents– Development of electronic curricula for residents which would include some
form of knowledge validation
• Development of a center of excellence certification – c.f., NAFCcertification
• Clinic safety training for use of local anesthetics – does this exist fordentistry?
• Question: suggestions for marketing/promoting the SPC and its bestpractices proceedings
• Question: at what point does the SPC consider inviting attendees to pay toattend the annual meetings or deploy satellite training courses?