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WEDNESDAY 3 March 2021 "Chemical, structural biology and disease treatment"
Chairs: Professor Aristidis Moustakas, Uppsala University, Sweden Professor Achilleas Theocharis, University of Patras, Greece
LIVE
18.00-18.10 Welcome / Introduction
18.10 - 18.40
KEYNOTE LECTURE 1 Ivan Đikić, MD, PhD, Professor of Biochemistry, Director, Institute of Biochemistry II, Fellow, Max Planck Institute for Biophysics, Group leader, Buchmann Institute for Molecular Life Sciences, University Hospital of Goethe University Frankfurt, Germany “Cell-based chemical screens for inhibitors of the SARS-CoV2 papain-like protease”
18.50 - 19.00 SELECTED ORAL PRESENTATION 1 Vasiliki Lygirou, Biomedical Research Foundation, Academy Of Athens, Greece “Proteomic analysis of CD138+ cells for predicting the response of multiple myeloma patients to commonly used therapeutic regimens”
19.00-19.10 COFFEE BREAK
19.10-19.40 KEYNOTE LECTURE 2 Sonia Lain, Professor, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden “From a phenotypic screen to the structure of a small molecule bound to its target, and the challenges beyond”
19.50-20.10 KEYNOTE LECTURE 3 Alexandra Teleki, Associate Professor, SciLifeLab Fellow, Co-director Swedish Drug Delivery Center, Department of Pharmacy, Uppsala University, Sweden “Scalable synthesis of functional nanoparticles for disease diagnosis and oral drug delivery”
20.15-20.25 SELECTED ORAL PRESENTATION 2 Nikolaos Fourkiotis, University of Patras, Greece “Unravelling the architecture and biochemical properties of SARS-CoV-2 nsP3 domains”
20.30-20.40 COFFEE BREAK
20.40 - 21.00 E-POSTERS SESSION (RECORDED)
P1 Investigation of the anticancer impact of mistletoe (Viscum album L.) callus and stem protein extracts through the assessment of the cytotoxic activity and metabolic profiling of the breast MCF7 adenocarcinoma cell line Sophia Kakoura1, Sophia Mavrikou1*, Vasileios Tsekouras1, Konstantinos A. Aliferis2,3*, Maira Lykogianni2,4, Evgenia-Anna Papadopoulou2, Georgia Moschopoulou1, Spyridon Kintzios1 1 Laboratory of Cell Technology, Agricultural University of Athens, Athens, Greece 2 Laboratory of Pesticide Science, Agricultural University of Athens, Athens, Greece
3 Department of Plant Science, McGill University, Montreal, Canada
4 Laboratory of Efficacy Assessment of Pesticides, Benaki Phytopathological Institute, Athens, Greece
*e-mail: [email protected], [email protected]
P2 Studying the role of non-RING elements of Arkadia in the auto-ubiquitination mechanism Maria Birkou1, Konstantinos D. Marousis1, Georgia N. Delegkou1, Vasso Episkopou2, Georgios A. Spyroulias1 1Department of Pharmacy, University of Patras, Patra, Greece,
2School of Medicine, Imperial College, London, United
Kingdom Email: [email protected]
P3 Nicotinic cholinergic system and COVID-19: in silico identification of interactions between α7 nicotinic acetylcholine receptor of SARS-Co-V and SARS-CoV-2 Spike glycoprotein George Lagoumintzis1,2, Christos Chasapis1, Nikolaos Alexandris1, Demetrios Leonidas3, George Papadopoulos3, Socrates Tzartos1, Elias Eliopoulos4, Konstantinos Farsalinos1, Konstantinos Poulas1,2*
1Department of Pharmacy, University of Patras, 26500, Rio-Patras, Greece,
2Institute of Research and Innovation,
Patras Science Park SA, 26500 Patras, Greece, 3Department of Biochemistry and Biotechnology, University of Thessaly,
Biopolis, 41500 Larissa, Greece, 4Department of Biotechnology, Laboratory of Genetics, Agricultural University of
Athens, Iera Odos 75, 11855 Athens, Greece *e-mail: [email protected]
P4 STUDY OF THE E2 UBE2D2 S22R MUTATION ON THE UBIQUITINATION PATHWAY OF ARKADIA Georgia N. Delegkou1, Konstantinos D. Marousis1, Maria Birkou1, Vasso Episkopou2, Georgios A. Spyroulias1* 1Dept of Pharmacy, U of Patras, GR-26504, Greece,
2School of Medicine, Imperial College, London, United Kingdom
*e-mail: [email protected]
P5 The Plasmodium NF-Y like complex is required for malaria parasite transmission Maria Andreadaki1, Sofia Tzagaraki1, Lefteris Spanos1, Elena Deligianni1, Ioanna Kavelaki1, Antonio Chaves-Sanjuan2, Marco Nardini2, Inga Siden-Kiamos1, Chiara Currà1* 1 Institute of Molecular Biology and Biotechnology, FORTH, Heraklion Crete, Greece, 2Dept of biosciences, University of Milano, Italy
*email:[email protected]
P6 Expression, purification and biophysical characterization of recombinant polypeptides of Hepatitis E Open Reading Frame 1 (ORF1) Maria D. Politi1, Konstantina Kaperoni 1, Maria Birkou1, Angelo Galo1, Georgios Bouras1, Dioni Ntonti1, Bruno Coutard2, Georgios A. Spyroulias1. 1Department of Pharmacy, University of Patras, Patra, Greece
2AFMB, UMR 7257 CNRS/ University of Merseille, Merseille CEDEX 9, France
P7 Understanding the conformational differences between Tyk2 kinase and a protective variant against autoimmune diseases through microsecond-scale molecular dynamics simulations Nastazia Lesgidou, Metaxia Vlassi*
Protein Structure & Molecular Modeling laboratory, Institute of Biosciences & Applications, National Center for Scientific Research “DEMOKRITOS”, Athens, 15310, Greece *Corresponding author: [email protected]
P8 Inhibition activity of curcumin derivatives against the glutathione S-transferase enzyme Panagiota Pantiora1,2*, Dimitris Matiadis2, Barbara Mavroidi2, Fereniki Perperopoulou1, Marina Sagnou2, Maria Pelecanou2, Nikolaos Labrou1
1Laboratory of Enzyme Technology, Department of Biotechnology, School of Food, Biotechnology and Development,
Agricultural University of Athens, 2Laboratory of Structural Studies of Biomolecules and Drugs,
Institute of Biosciences & Applications, NCSR "Demokritos"
*email: [email protected]
P9 NMR study of the activation of the Heme-Nitric Oxide/Oxygen Binding (H-NOX) domain from Νostoc sp, a homologue of soluble Guanylate Cyclase (sGC) by chemical compounds Aikaterini I. Argyriou1, Garyfallia I. Makrynitsa1, Dimitrios E. Providas1, Periklis Charalampous1, Aikaterini A. Zompra1, Stavros Topouzis1, Andreas Papapetropoulos1,2, Georgios A. Spyroulias1*
1 Department of Pharmacy, University of Patras, GR-26504, Patras, Greece. 2 School of Health Sciences, Faculty of Pharmacy, University of Athens, GR-15 771, Athens, Greece *email: [email protected]
P10 Segmental isotope labelling of the multidomain LA protein for NMR structural study Aikaterini I Argyriou 1, Georgios A. Machaliotis1 Christine von Schroetter3, Eleni Kaliatsi2, Frédéric Allain3, Constantinos Stathopoulos2, Georgios A. Spyroulias*1
1 Department of Pharmacy, University of Patras, GR-26504, Patras, Greece
2 Department of Biochemistry, School of Medicine, University of Patras, GR-26504, Patras, Greece
3 Institute of Molecular Biology and Biophysics, ETH Zürich, CH-8093, Zürich, Switzerland
P11 Synthesis and Antiproliferative Activity of Novel Dehydroabietic Acid- Chalcone hybrids Sophia Grigoropoulou1, Dimitra Manou2, Antonia I. Antoniou1, Artemis Tsirogianni1, Achilleas D. Theocharis2,* and Constantinos M. Athanassopoulos 1,* 1 Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, GR-26504 Patras, Greece; [email protected] (S.G.); [email protected] (A.I.A.) 2 Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry,
Department of Chemistry, University of Patras, GR-26504 Patras, Greece; [email protected] (D.M.) * Correspondence: [email protected]; Tel.: +30-2610-997909 and [email protected]; Tel.: +30-2610-996029
P12 Isolation, structural elucidation of ent-15-kaurenes from Sideritis clandestina ssp. peloponnesiaca and their cancer antiproliferative efficacy V. D. Dimaki1, E. Stamopoulou1, D. Manou3, M. A. Fousteris2, A.D. Theocharis3, F. N. Lamari1* 1 Laboratory of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, University of Patras,
Greece 2 Laboratory of Medicinal Chemistry, Department of Pharmacy, University of Patras, Greece
3 Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece. *[email protected]
P13 Comparative NMR metabolomic analysis of nursed late preterm and healthy age-matched late preterms infants Styliani A. Chasapi1, Konstantina Matzarapi1, Panagiota D. Georgiopoulou1, Irini Christopoulou2, Anastasia Varvarigou2, Georgios A. Spyroulias1*
1Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece,
2Department of Paediatrics,
University of Patras Medical School, General University Hospital, Patras, Greece. *email: [email protected]
P14 Exploring the therapeutic potential of mitochondrial targeting Chrysoula Komini1,2, Eleftheria A. Georgiou3, Angeliki-Maria Vlaikou1,2, Markus Nussbaumer1,2, Amalia D. Kalampaliki3, Ioannis K. Kostakis3, Michaela D. Filiou1,2,*
1Laboratory of Biochemistry, Department of Biological Applications and Technology, School of Health Sciences,
University of Ioannina, Greece 2Biomedical Research Division, Institute of Molecular Biology and Biotechnology, Foundation of Research and
Technology-Hellas (IMBB-FORTH), Ioannina, Greece 3Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Greece
P15 AZD9567, a Non-steroidal Selective Glucocorticoid Receptor Modulator Dimitra Siakouli1, Georgios Panagiotou1, Vassiliki Ganou1, Eleni-Fani Gkotsi1, Aristotelis Chatziioannou2, Olga Papadodima1, Michael N. Alexis1, Dimitra J. Mitsiou1*, 1Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece
2Center of Systems Biology, Biomedical Research Foundation of the Academy of Athens, Greece
*e-mail: [email protected]
P16 Physicochemical and structural properties of cinnamic acid-NO donor hybrids for anticancer activity Ioanna-Chrysoula Tsopka1*, Dimitra Hadjipavlou-Litina1
1Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki,
Greece *email: [email protected]
P17 Α computational approach for the evaluation of natural products as potential inhibitors of Αβ oligomerization in Alzheimer’s disease Dimitra S. Bezantakou, Nikos C. Papandreou, Avgi Apostolakou, Vassiliki A. Iconomidou*
Section of Cell Biology and Biophysics, Department of Biology, School of Science, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 157 01, Greece *email: [email protected]
P18 Aggregation studies on peptide-analogues of human Cathepsin D Eleni Dalli1, Georgia Nasi1, Panagiotis Spatharas1, Athina Lycoura2, Vassiliki Magafa2, Vassiliki Iconomidou1* 1Section of Cell Biology and Biophysics, Department of Biology, National and Kapodistrian University of Athens, Athens
157 01, Greece, 2Department of Pharmacy, University of Patras, Patras 26504, Greece
*email: [email protected]
P19 A peptide-analogue of Clusterin as a potential inhibitor of Alzheimer’s amyloid-beta (Aβ) peptide: a Computational Study Marilena K. Theodoropoulou, Nikolaos C. Papandreou, Georgia I. Nasi, Vassiliki Α. Iconomidou* Section of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15701, Athens *e-mail: [email protected]
