Prognosis of asymptomatic and symptomatic undiagnosed chronic obstructive pulmonary disease in the general population: a prospective cohort study
Yunus olak, PhD; Shoaib Afzal, PhD; Brge G. Nordestgaard, DMSc; Jrgen Vestbo, DMSc; and Peter Lange, DMSc
Department of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark (Dr. olak).
Department of Public Health, Section of Social Medicine, University of Copenhagen, Copenhagen, Denmark (Dr. olak and Prof. Lange).
The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark (Dr. olak, Dr. Afzal, Prof. Nordestgaard, and Prof. Lange).
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (Dr. olak, Dr. Afzal, Prof. Nordestgaard, and Prof. Lange).
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark (Dr. Afzal and Prof. Nordestgaard).
Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom (Prof. Vestbo).
Medical Unit, Respiratory Section, Hvidovre Hospital, Copenhagen University Hospital, Hvidovre, Denmark (Prof. Lange).
Correspondence:
Peter Lange, MD, DMSc
Professor, Consultant in Respiratory Medicine
Department of Public Health, Section of Social Medicine, University of Copenhagen
ster Farimagsgade 5, Postal Box 2099, DK-1015 Copenhagen K, Denmark
Phone: +45 26879020
E-mail: [email protected]
Key words: emphysema; bronchitis, chronic; diagnosis; forced expiratory volume; spirometry; smoking; asthma; airway obstruction.
Summary of total word count and other requirements:
Abstract word count: 313 (max. 300)
Total word count: 3401 (max. 3000)
References: 33 (max. 30)
Tables/Figures: 5 (no max.)
Supplement is available
Abstract
Background:Chronic obstructive pulmonary disease(COPD) can be detected early using spirometry, but its use is only recommended in symptomatic smokers, although early stages of COPD may be asymptomatic. We investigated the prognosis of asymptomatic and symptomatic individuals with undiagnosed COPD in the general population.
Methods:Among 95 288 individuals aged 20-100years from the Copenhagen General Population Study, 32 518 were assigned being at risk for COPD, defined as, age 40years, cumulative tobacco consumption 10 pack-years, and no asthma. COPD was defined as a forced expiratory volume in 1 second(FEV1)/forced vital capacity(FVC)
