d-LIVER Showcase Workshop

Milano, May 2015

WEARABLE DEVICE FOR VITAL SIGNS MONITORING

Frode Strislandd-LIVER Showcase Workshop

Milano, May 27th 2015

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d-LIVER Showcase Workshop

Milano, May 2015

d-LIVER Wearable Device:Continuous physiological monitoring of liver patients in home settings

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Objective: Develop device for continuous, ambulatory measurements of vital signs for early detection of patient exacerbations.

Main usage scenarios: Intermittent measurements during shorter time sequences (days-weeks-months), such as assessment of medical intervention effects.

1. Establish baseline at start a new treatment programme (such as d‒LIVER enrolment).

2. Lifestyle change, outcome assessment and patient motivational tool (lifestyle changes such as exercise, substance abuse, diet, etc.).

3. Assessment of effect of medication adjustments.

4. Monitoring requested by medical personnel for patient status assessment.

d-LIVER Showcase Workshop

Milano, May 2015

Wearable Device: Design Approach

Usability essential:

Mounted by patient

Worn for many hours

Liver patient skin issues

Development concerns

High quality electrodes needed for ICG measurements

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d-LIVER Showcase Workshop

Milano, May 2015

d-LIVER Wearable Device:

Target measurement parameters

Parameters selected based on clinical needs assessments within the project

• Heart rate

• Heart rate variability

• Skin temperature

• Activity level

• Step Counter

• Upper body posture

• Pulse transit time

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d-LIVER Showcase Workshop

Milano, May 2015

Wearable Device

System architecture

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d-LIVER Showcase Workshop

Milano, May 2015

Sensors used to calculate Pulse Transit Time to extract blood pressure

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Pulse Transit Time (PTT): The time it takes from the heart valve opens until the blood pressure wave reaches the periphery. PTT depends on blood pressure; the higher pressure, the shorter PTT.

Sensors used• Electro CardioGraphy (ECG) - Used to

detect the heartbeat start impulse• Impedance CardioGraphy (ICG) -

Used to detect opening of the aortic valves

• PhotoPlethysmoGraphy (PPG) - Used to detect the peripheral pressure wave

d-LIVER Showcase Workshop

Milano, May 2015

Wearable device

Communication configurations

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2. HDP IEEE

11073 agent

SpO2

1.Serial Port

Protocol

d-LIVER Showcase Workshop

Milano, May 2015

Wearable Device:

Status on clinical testing

Testing on healthyvolunteers (SINTEF)

Testing on 24 patientsalongside an ongoing NASH exercise study at University of Newcastle

d-LIVER system testing at Charité

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Testing scheduled

d-LIVER Showcase Workshop

Milano, May 2015

Acknowledgements

The d-LIVER project is partly funded by the European Commission (Contract No. 287596)

www.d-liver.eu

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StemCellSystems