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Page 1: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

1

We will begin momentarily at 2pm ET

Slides available now! Recordings will be available to ACS members after one week.

1 Contact ACS Webinars ® at [email protected]

www.acs.org/acswebinars

Type them into questions box!

2

“Why am I muted?”

Don’t worry. Everyone is

muted except the presenter

and host. Thank you and

enjoy the show.

Contact ACS Webinars ® at [email protected]

Have Questions?

Page 2: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

2

Have you discovered the missing element?

3

Find the many benefits of ACS membership!

www.acs.org/2joinACS

Benefits of ACS Membership

4 www.acs.org/2joinACS

Chemical & Engineering News (C&EN) The preeminent weekly news source.

NEW! Free Access to ACS Presentations on Demand® ACS Member only access to over 1,000 presentation recordings from recent ACS meetings and select events.

NEW! ACS Career Navigator Your source for leadership development, professional education, career services, and much more.

Page 3: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

3

5

facebook.com/acswebinars

Like us on Facebook!

Be a featured fan on an upcoming webinar! Write to us @ [email protected]

6

How has ACS Webinars benefited you?

®

“ACS Webinars benefits me by refreshing my

knowledge, showing me new approaches to

chemistry, learning new techniques. Many ACS

Webinars are really fun to watch!”

Renee Roberts, Environmental Scientist

Industry Assistance,

Training, & Outreach Unit

Hazardous Waste Management

Department of Toxic Substances Control

Page 4: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

4

7

facebook.com/acswebinars

@acswebinars

youtube.com/acswebinars

8

See all the ACS Webinets at youtube.com/acswebinars

“ACS Webinets are 2 minute segments that bring

you valuable insight from some of our most popular

full length ACS Webinars ” ®

TM

on

Page 5: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

5

9 Contact ACS Webinars ® at [email protected]

All recordings of ACS Webinars will be available to

current ACS members one week after the Live

broadcast date.

Live weekly ACS Webinars will continue to be

available to the general public.

®

®

Upcoming ACS Webinars www.acs.org/acswebinars

10

®

Contact ACS Webinars ® at [email protected]

Wednesday, March 18, 2015 at 11am CST

“Panorama Energético en la Era de la Sustentabilidad: Energías

Renovables y Dispositivos Emergentes”

Dr. Luis Echegoyen, Profesor de Química, Universidad de Texas, El Paso

Dr. Héctor D. Abruña, Profesor de Química, Universidad de Cornell

Dr. Ingrid Montes, ACS Junta de Directores y Profesora de Química

Orgánica, Universidad de Puerto Rico, Recinto de Río

Thursday, February 26, 2015 at 2pm ET

“Fragment-Based Drug Design Strategies”

Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc.

Dr. Judd Berman, Chief Scientific Officer, Dalton Medicinal Chemistry and a Co-

founder and Consultant, Nobelex Biotech, Inc.

Page 6: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

6

American Chemical Society

#chemchamps

All Chemists 35 y.o. or under!

ChemChamps 2015 – Win a Trip to Boston!

Send us a 2-3 min video via Vimeo by April 8, 2015

www.acs.org/chemchamps

12

“Bringing CO2 Monitoring to You: Communicating Atmospheric Chemistry”

This ACS Webinar is co-produced with the ACS Chemistry Champions Competition

www.acs.org/acswebinars www.acs.org/acswebinars Slides available now! Recordings will be available to ACS members after one week.

Ms. Alexis Shusterman 2014 Chem Champs Runner-Up

Ph.D. Candidate, UC Berkeley Dr. Darcy Gentleman

Manager, Engagement and Science

Communications,

The American Chemical Society

Page 7: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

7

Novel Network-Based Instrumentation for

High Spatial and Temporal Resolution

Monitoring of Atmospheric CO2

Alexis Shusterman

[email protected]

13

IPCC Fifth Annual Report:

warming cooling 14

Page 8: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

8

from Choi et al. 2014

observations

modeled fit

1σ variation range

Particulate Matter

(co-emitted with CO2)

15

How many CO2 sensors does the NOAA CarbonTracker program currently maintain in the lower 48 United States?

Audience Survey Question

16

ANSWER THE QUESTION ON SCREEN

• 10 • 30 • 300 • 480 • 1,000

Page 9: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

9

How many CO2 sensors does the NOAA CarbonTracker program currently maintain in the lower 48 United States?

Audience Survey Question

17

ANSWER THE QUESTION ON SCREEN

• 10

• 30 one every ~500 km • 300 • 480 • 1,000

NDIR CO2 sensor

18

Page 10: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

10

2km Oakland, CA 19

10 km 10 km 10 km

PRIOR POSTERIOR DIFFERENCE

c/o Alexander J. Turner

20

Page 11: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

11

10 km 10 km 10 km

PRIOR POSTERIOR DIFFERENCE

c/o Alexander J. Turner

10 km

21

2km Oakland, CA 22

Port of Oakland

Page 12: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

12

Daily CO2 Levels at Port of Oakland

ships stationary

ships in motion

3 PM 8 PM 10 AM 5 AM

23

What might be raising CO2 concentrations on days when the ships are docked?

Audience Survey Question

24

ANSWER THE QUESTION ON SCREEN

• increased ship engine idling • increased diesel truck traffic • circulation blocked by large ships • correlation with weather patterns • correlation with commuter patterns

Page 13: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

13

What might be raising CO2 concentrations on days when the ships are docked?

Audience Survey Question

25

ANSWER THE QUESTION ON SCREEN

• increased ship engine idling • increased diesel truck traffic • circulation blocked by large ships • correlation with weather patterns

• correlation with commuter patterns

NDIR CO2 sensor

26

Page 14: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

14

NDIR CO2 sensor

electrochemical trace gas sensors

particulate matter sensor 27

Future Directions

light-duty

passenger

vehicles

heavy-duty diesel

Harley et al. 2005

1999-2000 Emissions Factors 28

Page 15: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

15

29

Novel Network-Based

Instrumentation for High Spatial and

Temporal Resolution Monitoring of

Atmospheric CO2

Alexis Shusterman

[email protected]

30

Page 16: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

16

CO2 Monitoring in

High-Definition

Alexis Shusterman

31

CO2 Monitoring in

High-Definition

Alexis Shusterman

32

Page 17: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

17

from Choi et al. 2014

observations

modeled fit

1σ variation range

Particulate Matter

(co-emitted with CO2)

33

half mile

34

Page 18: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

18

half mile

35

half mile

36

Page 19: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

19

37

38

Page 20: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

20

39

?

40

Page 21: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

21

?

41

42

Alexis

Page 22: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

22

43

Alexis Alex Ron

Jill Catherine

CO2 44

Page 23: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

23

45

46

?

Page 24: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

24

47

?

CO2 48

Page 25: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

25

CO2 49

50

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3/11/2015

26

51

52

Page 27: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

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53

011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011011010100101110100001010100111100001101010100001010101111110101011000101010001110101101011101011111101010110001010100011101011010110110101001011101000010101001111000011010101000010101011111101010110001010100011101011010110110101001011101000010101001111000011010101000010101011111101010110001010100011101011010110110101001011101000010101001111000011010101000010101011111101010110001010100011101011000111010110001110101100

54

Page 28: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

28

55

CO

2

ships moving ships still

56

?

Page 29: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

29

57

?

58

?

Page 30: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

30

59

?

to be continued…

What do you find to be the most memorable parts of a presentation, video, or article?

Audience Survey Question

60

ANSWER THE QUESTION ON SCREEN

• the opening line • visuals – graphs and animations • prose – text or audio • the author’s credentials • the final thought

Page 31: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

31

What do you find to be the most memorable parts of a presentation, video, or article?

Audience Survey Question

61

ANSWER THE QUESTION ON SCREEN

• the opening line • visuals – graphs and animations • prose – text or audio • the author’s credentials

• the final thought

Future Directions

light-duty

passenger

vehicles

heavy-duty diesel

Harley et al. 2005

1999-2000 Emissions Factors 62

Page 32: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

32

63

64

Page 33: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

33

PREVENTABLE DISEASES

65

CHEMICAL WASTE

66

Page 34: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

34

CHEMICAL WASTE

CALL

TO

ACTION 67

CHEMICAL WASTE

Simplicity

68

Page 35: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

35

CHEMICAL WASTE

Simplicity

Audience

69

CHEMICAL WASTE

Simplicity

Audience

Story

70

Page 36: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

36

71

Jill Teige

Alex Turner

Catherine

Newman

Ron Cohen

Resources

BEACO2N

http://beacon.berkeley.edu

[email protected]

Yale Center for Climate Change Communication

Alan Alda Center for Communicating Science

Veritasium: An Element of Truth

Don’t be Such a Scientist (Randy Olson)

Am I Making Myself Clear? (Cornelia Dean)

Madlands (Anna Rose)

Thank you!

72

“Bringing CO2 Monitoring to You: Communicating Atmospheric Chemistry”

This ACS Webinar is co-produced with the ACS Chemistry Champions Competition

www.acs.org/acswebinars www.acs.org/acswebinars Slides available now! Recordings will be available to ACS members after one week.

Ms. Alexis Shusterman 2014 Chem Champs Runner-Up

Ph.D. Candidate, UC Berkeley Dr. Darcy Gentleman

Manager, Engagement and Science

Communications,

The American Chemical Society

Page 37: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

37

Upcoming ACS Webinars www.acs.org/acswebinars

73

®

Contact ACS Webinars ® at [email protected]

Wednesday, March 18, 2015 at 11am CST

“Panorama Energético en la Era de la Sustentabilidad: Energías

Renovables y Dispositivos Emergentes”

Dr. Luis Echegoyen, Profesor de Química, Universidad de Texas, El Paso

Dr. Héctor D. Abruña, Profesor de Química, Universidad de Cornell

Dr. Ingrid Montes, ACS Junta de Directores y Profesora de Química

Orgánica, Universidad de Puerto Rico, Recinto de Río

Thursday, February 26, 2015 at 2pm ET

“Fragment-Based Drug Design Strategies”

Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc.

Dr. Judd Berman, Chief Scientific Officer, Dalton Medicinal Chemistry and a Co-

founder and Consultant, Nobelex Biotech, Inc.

74

“Bringing CO2 Monitoring to You: Communicating Atmospheric Chemistry”

This ACS Webinar is co-produced with the ACS Chemistry Champions Competition

www.acs.org/acswebinars www.acs.org/acswebinars Slides available now! Recordings will be available to ACS members after one week.

Ms. Alexis Shusterman 2014 Chem Champs Runner-Up

Ph.D. Candidate, UC Berkeley Dr. Darcy Gentleman

Manager, Engagement and Science

Communications,

The American Chemical Society

Page 38: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

38

American Chemical Society

#chemchamps

All Chemists 35 y.o. or under!

ChemChamps 2015 – Win a Trip to Boston!

Send us a 2-3 min video via Vimeo by April 8, 2015

www.acs.org/chemchamps

Be a featured fan on an upcoming webinar! Write to us @ [email protected]

76

How has ACS Webinars benefited you?

®

“ACS Webinars benefits me by refreshing my

knowledge, showing me new approaches to

chemistry, learning new techniques. Many ACS

Webinars are really fun to watch!”

Renee Roberts, Environmental Scientist

Industry Assistance,

Training, & Outreach Unit

Hazardous Waste Management

Department of Toxic Substances Control

Page 39: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

39

77

facebook.com/acswebinars

@acswebinars

youtube.com/acswebinars

Benefits of ACS Membership

78 www.acs.org/2joinACS

Chemical & Engineering News (C&EN) The preeminent weekly news source.

NEW! Free Access to ACS Presentations on Demand® ACS Member only access to over 1,000 presentation recordings from recent ACS meetings and select events.

NEW! ACS Career Navigator Your source for leadership development, professional education, career services, and much more.

Page 40: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

40

79

ACS Webinars does not endorse any products or

services. The views expressed in this

presentation are those of the presenter and do

not necessarily reflect the views or policies of the

American Chemical Society.

®

Contact ACS Webinars ® at [email protected]

Upcoming ACS Webinars www.acs.org/acswebinars

80

®

Contact ACS Webinars ® at [email protected]

Wednesday, March 18, 2015 at 11am CST

“Panorama Energético en la Era de la Sustentabilidad: Energías

Renovables y Dispositivos Emergentes”

Dr. Luis Echegoyen, Profesor de Química, Universidad de Texas, El Paso

Dr. Héctor D. Abruña, Profesor de Química, Universidad de Cornell

Dr. Ingrid Montes, ACS Junta de Directores y Profesora de Química

Orgánica, Universidad de Puerto Rico, Recinto de Río

Thursday, February 26, 2015 at 2pm ET

“Fragment-Based Drug Design Strategies”

Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc.

Dr. Judd Berman, Chief Scientific Officer, Dalton Medicinal Chemistry and a Co-

founder and Consultant, Nobelex Biotech, Inc.

Page 41: We will begin momentarily at 2pm ET...“Fragment-Based Drug Design Strategies” Dr. Daniel Erlanson, co-founder and President of Carmot Therapeutics, Inc. Dr. Judd Berman, Chief

3/11/2015

41

American Chemical Society

#chemchamps

All Chemists 35 y.o. or under!

ChemChamps 2015 – Win a Trip to Boston!

Send us a 2-3 min video via Vimeo by April 8, 2015

www.acs.org/chemchamps