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Wanabsorpsie
Abnormale absorpsie van enkele of veelvuldige nutriente in die gastro-intestinale sisteem.
3 komponente nodig vir optimale absorpsie Intraluminaal WANVERTERING
– Galsuur of pankreas ensiem gebrek Mukosale WANABSORPSIE
– Abnormale mukosa or onvoldoende funksionele derm lengte (‘Brush border surface area’) bv. Dunderm reseksie.
Post-mukosale limfdreinering obstruksie
Malabsorption Syndrome
Pallor/AnaemiaNight blindness (Vit A)
Osteoporosis withpathological fractures
Muscle wasting Muscle weakness
Tetany (Low Calcium)
Hypopigmentation/Pellagra(Niacin)
Ascites (Low Albumin)
Dehydration (Diarrhoea)Ecchymoses (Vit K
factor deficiency)
SteatorrhoeaIncreased fecal fat
Oedema (Low Albumin)Peripheral neuropathy
(B12 def)
Glossitis, stomatitisApthous ulcers (Iron & BVitamin deficiency)
Pathological Weight loss
Oorsake van Wanabsorpsie
Due to infective agents – Intestinal tuberculosis – HIV related malabsorption – Tropical sprue – Parasites e.g. Giardia lamblia.
Due to structural defects– Inflammatory bowel diseases -
Crohn's Disease – Fistulae, diverticulae and
strictures, – Infiltrative conditions - amyloidosis– Short bowel syndrome
Due to mucosal abnormality– Celiac disease – Cows' milk intolerance – Soya milk intolerance – Fructose malabsorption
Due to enzyme deficiencies– Lactase deficiency– Sucrose intolerance – Intestinal disaccharidase deficiency – Intestinal enteropeptidase
deficiency Due to digestive failure
– Pancreatic insufficiencies: Cystic fibrosis Chronic pancreatitis Pancreas carcinoma Zollinger-Ellison syndrome
– Bile salt malabsorption Terminal ileal disease Obstructive jaundice Liver cirrhosis Bacterial overgrowth Primary bile acid diarrhea
Celiac siekte
Gluten sensitiewe enteropatie Algemeen in Europieërs (1:300) Seldsaam in swart mense HLA DQ2 en DQ8 Kan op enige ouderdom presenteer Gewoonlik - moegheid, gewigsverlies en
anemie in ‘n jong/middeljarige dame.
Celiac siekte
Word geasossieer met:– Tipe I diabetes– Tiroid siekte– Addison se siekte (Autoimmuun)
Diagnose:– Anti-endomesiale antiliggame– anti-tTG (weefsel transglutaminase)– Dun derm mukosale biopsie
Vermeerderde intraepiteliale limfosiete Kript hiperplasia Villus atrofie
Celiac siekte
Terapie/behandeling– Streng Gluten vrye dieet. Dietkundige belangrik.– Supplemente (FeSo4, Vitamiene)– Behandel osteoporose– Ander geasossierde autoimmuun toestande moet
uitgeskakel word.– Goeie opvolg
Klieniese beeld Antiligame
Kroniese pankreatitisDefinisie
Onomkeerbare pankreatiese skade Histologiese or radiologiese bewys van
kroniese inflammasie en fibrose Verlies aan eksokrine (asinere selle) en
endokriene (eiland selle) pankreas weefsel.
Kroniese pankreatitisOorsake (TIGAR-O)
Toxic/Metabolic– Alcohol– Smoking– Hypercalcaemia– Hyperlipidaemia
Idiopathic– Early onset– Late onset– Tropical
Genetic– Autosomal dominant
Hereditary pancreatitis (PRSS1 mutations)
– Autosomal recessive or modifier genes
CFTR mutations SPINK1 mutations Others
Alcohol and Gallstones most common causes in developed countries (70%)
Autoimmune-Autoimmune pancreatitis-IgG4 related systemic disease
Recurrent•Post Necrotic•Chronic alcoholism•Diabetes Mellitus•Radiotherapy
Obstructive•Benign pancreatic duct obstruction
•Gallstones•Stricture•Pancreas divisum
•Malignant stricture•Ampullary of duodenal carcinoma•Pancreatic adenocarcinoma
Kroniese pancreatitisPatofisiologie (Alcohol)
Direct toxins and toxin
metabolites
Necrosis with Fibrosis
Intraductal plugging and obstruction
Oxidative stress
Alcohol
Cytokine releasestimulate stellate
cells to form collagen(fibrosis) and increase
cell - mediated inflammation
Chronic Pancreatitis
Kroniese pankreatitisKliniese einskappe
Abdominale pyn
SteatorrhoeaDiabetes Mellitus
Ander:- Moegheid, etc- Gewigsverlies agv. wanabsorpsie- Pain geassosieered met hoe proteien and vet iname
Kroniese pankreatitisAbdominale pyn
Most common clinical problem Decreases appetite and limits food
consumption - weight loss and malnutrition Dramatic reduction in quality of life Character:
– Epigastric, often with radiation to the back. – Boring, deep, and penetrating and is often – Associated with nausea and vomiting.– Relieved by sitting forward or leaning forward, the
knee-chest position– Worsens after a meal and often is nocturnal.
Possible causes:– Acute inflammation/noxious stimuli– Increased intra-pancreatic pressure and ischaemia– Neuropathic (Alterations in nociceptive nerves) – Other
Kroniese pankreatitisSteatorrhoea
Exocrine insufficiency. Passage of bulky, floating, foul-smelling
stools or may even note the passage of frank oil droplets.
Occurs when pancreatic lipase secretion is reduced to less than 10% of the maximum output.
A feature of far-advanced chronic pancreatitis or complete blockage of the pancreatic duct.
Kroniese pankreatitisDiabetes Mellitus
Endocrine insufficiency Half of patients with chronic
pancreatitis who develop diabetes will require insulin.
Insulin-producing beta cells and glucagon-producing alpha cells are injured.
Increased risk of prolonged and severe hypoglycemia with over vigorous insulin treatment due to the lack of a compensatory release of glucagon.
Kroniese pankreatitisDiagnose(1)
Kliniese eienskappe (Abdominale pyn, Steatorrhoea, Diabetes Mellitus)
Pankreas funksie toetse– Direk
Direct hormonal stimulation tests are believed to be the most sensitive function test for chronic pancreatitis. Bicarbonate estimation after Secretin administration. (ERCP) – invasive, not routinely done.
– Indirek Serum Trypsinogen Pancreatic Enzymes in Stool eg chymotrypsin or elastase Fecal Fat Excretion/Steatocrit
Kroniese pankreatitisDiagnose(2)
Beelding– Abdominale x-straal with pankreas kalsifikasies– CT Scan/MRI– Ultrasound (Conventional/EUS)– ERCP/MRCP
Ander– IgG4, ESR, RF, Calcium, Triglyceride levels
Kroniese pankreatitisBehandeling
No curative therapy available Behandel die oorsaak. Stop rook. Stop alkohol. Abdominale pyn
– Analgesia– Anti-oxidante– Vermindering van intra-pankreatiese druk en onderdrukking van pankreas uitskeiding
Non-enteriese bedekte ensiem vervanging PPI
– Endoskopiese behandeling– Chirurgie
Steatorrhoea Verminder vet in diet (<20g/dag) Pankreatiese ensiem vervanging (bv. Pancrelipase - CreonTM) Suur onderdrukking met ‘n PPI (Verhoog duodenale pH for optimale lipase activiteit.
Diabetes Mellitus Insulin therapie (NB. Risiko hoer vir hypoglukemie)
Ander Supplemente, “fat soluble” vitamiene (A, D, E, K)
Kroniese pankreatitisKomplikasies
Pseudokiste Bloeding
– Pseudokiste– Pseudoaneurisme– Milt thrombose met varices wat bloei
Obstruksie (Gemene galbuis, duodenale) Pankreas Fistel
– Na Pseudokist– Externe (chirurgie)– Interne (Askites, pleurale effisie)
Kanker– Risk highest with hereditary pancreatitis
and smoking– Pancreatic adenocarcinoma – CA19-9
Dysmotiliteit– Gastroparese and antroduodenale dysmotiliteit
perigastric inflammation hormonal changes associated with chronic pancreatitis (e.g. CCK) side effect of narcotic analgesics.