Walter Reed National Military Medical Center Directorate for Professional Education Department of Research Programs Introduction to Research at WRNMMC

Walter Reed National Military Medical CenterDirectorate for Professional Education

Department of Research Programs

Introduction to Research at WRNMMC

Marina Borovok, PhDHead of Research Education,

Department of Research Programs, WRNMMC

September 2011

Research Course 2Research Course 2

Disclosure Statement :

This CE/CME activity

does not have commercial support,

and has no conflicts of interest.

2011


Learning Objectives

1. Describe clinical research and the research process steps

2. Discus research at WRNMMC and it’s unique opportunities.

3. Know about research support available at WRNMMC.

4. Recognize IT tools that support research collaboration and communication from anywhere at any time.

2011

LO 1: Describe clinical research and the research process steps

Before you start your research at WRNMMC, you need to do the following THREE steps:

Step 1: Obtaining a DKO/AKO account

Step 2: Registering with IRBNet, e-portal for publications and protocol submission.

Step 3: Completion of CITI training

2011 Research Course 4

5

Research Cue Card

2011 Research Course

Step 1: Obtaining a DKO/AKO accountAKO/DKO platform for research purposes

What is AKO?

Army Knowledge Online (AKO) is the world's largest and secure electronic platform.

AKO is currently serving over 2.26 million users.

What is DKO?

Defense Knowledge Online (DKO) is an information sharing network required by the Department of Defense to support secure access to information (portal).

DKO is using AKO as a platform.


7

MANY Benefits of DKO1. Universal Email in the .mil environment.

2. Virtual workspace (telework) any time especially in times of national disaster (Sept 11, Pandemic, etc) or exercises (example: DCO)

3. Virus and Spam scanning for over 3 Billion messages per year.

4. Provides access to over 2K free training courses via JKO, etc.

5. Use AKO/DKO credentials to access MyPay, Tricare Online and over 1,200 other DOD applications that use AKO/DKO SSO services.

6. If you have Internet access, you can access AKO/DKO securely from anywhere at any time

7. Centralized Helpdesk (open 24/7) supporting 2.26M users and over 1,200 DoD applications.

8. Use AKO/DKO Portal as a Virtual Thumb Drive ensuring files and folders needed are available regardless of location.

9. Social capabilities such as milSUITE allow you to find new people working on similar projects or with similar interests.

10. Communicate with anyone in DoD via IM, eMail, video messaging.

11. Over 50K deployed US Armed Forces members use AKO/DKO while deployed to many places worldwide.

2011 Research Course

AKO/DKO platform for research purposes The Defense Medical Research Network (DMRN)

For better management of research processes, The Defense Medical Research Network (DMRN) was created. It is a DoD-wide web-based networking solution for all your research management, compliance and oversight needs. Located on AKO/DKO platform at: https://www.us.army.mil/suite/page/596540

IRBNet

IRBNet is the industry leading software, a robust set of electronic tools supporting the management, submission, review and oversight of our research protocols.

IRBNet entry is available through DMRN page that located on AKO/DKO site.


Step 1: Obtaining a DKO/AKO account

Go to the Defense Medical Research Network (DMRN)page on DKO/AKO website at https://www.us.army.mil/suite/page/596540

Cue Card Reference:


Step 1: Obtaining a DKO/AKO account(cont.)

Login using your AKO/DKO username and password

Research Course 102011


Research Course 11

You are at the DMRN site at https://www.us.army.mil/suite/page/596540

Click on the IRBNet Entry button

2011


Research Course 12

Instructions are at the RCRS websitehttps://nnmcintra/SiteDirectory/RCRS/IRBNet/Forms/AllItems.aspx.

Questions? Contact Ms. Dale Gregory 301 295-8239 [email protected]

2011

Step 2: Registering with IRBNet, e-portal for publications and protocol submission.

Cue Card Reference:

Instructions are at the RCRS websitehttps://nnmcintra/SiteDirectory/RCRS/IRBNet/Forms/AllItems.aspx.


Step 2: Registering with IRBNet, e-portal

for publications and protocol submission (cont.)

Questions?

Please contact Mr. Luis Calvo

at [email protected],

301 295-2269.


Step 3: Completion of CITI trainingCue Card

Reference:

Principal Investigators, Associate Investigators, Research Staff, as well as anyone coming into contact with Human Subjects or involved with the consent process or study design are required to complete this course.


Step 3: Completion of CITI training

The course is available at https://www.citiprogram.org

First Time Users need to register athttps://www.citiprogram.org/enroll/courseregistration1.asp?language=english.

Questions?

Contact Dr. Marina Borovok 301 295-2876

[email protected] Course 162011

Now you are done with the registrations and training.

What is next?


Next steps: 4-5The entire research writing process can be divided

into easily manageable and clear steps:

STEP 4: Develop a Research Question

Select a topic

Discuss Research Ideas

Find Sources to support your ideas

STEP 5: Submit your proposal via

Proposal Approval

Funding (if needed)

18Research Course

Step 4: Develop Research Question Good research question: could the "FINER" criteria be applied to it?

F- Feasible. Is the question answerable? Do you have access to all the materials you will need to do the study?

Do you have access to enough subjects? Will you have enough time and money? Do you have the expertise to do this study or can you collaborate with

someone who does?

I- Interesting. The question has to be interesting to the investigator, but should also be interesting to others.

N- Novel. Has this study been done before? Does it add to the current body of medical knowledge?

E- Ethical. Risk/benefit ratio? Can the study be done with a minimal risk? Will an IRB approve the study?

R- Relevant. Will it further medical science? Will the results change clinical practice, health policy or point towards further avenues of research?

If your question fails on any one of these 5 criteria, it is probably not worth putting much effort into.

STEP 4: Good research question (cont.)

Readings: • Designing clinical research: an epidemiologic approach,

3rd ed., by Stephen B. Hulley, et.al.Lippincott Williams & Wilkins, 2007ISBN: 07-8178210-4;

• Research begins with the question.http://familymed.uthscsa.edu/facultydevelopment/elearning/ResearchQuestions.swf


Step 4: Research topic selection

Cue Card

Reference:

In order to do that you need to consult with your Department Chair/Supervisor/Mentor.

Need help to choose your Mentor?

Please contact Dr. Marina Borovok

at [email protected], 301 295-2876.


Step 4: Research topic selection (cont.)In case if you need HELP


Choose your mentor, and ask him/her to help. INTERNET Web resource :

http://nnmcresearch.wikispaces.com/NNMC-USUHS+Mentorship+Project

Step 4: Research topic selection (cont.) New: Protocol Outreach Program

• Protocol Outreach Program to discuss research ideas and roadmap:– Clinician, statistician, regulatory reviewer, laboratory scientist– 45 min appointments for research ideas and roadmap. More information will be provided by Dr. Klote (Module 6), and Dr. Bernstein (Module 7).

• To schedule an appointment please contact Ms. Dale Gregory at

301 295-8239, or [email protected]


Step 5: Protocol submission via


Submission instructions are available on the IRBNet portal, under Forms and Templates.

Questions? Contact DRP 301 295-8239 [email protected]

Cue Card Reference:

Next steps are: Proposal Approval (SRP,IRB approval),

Funding (if needed).

These steps will be successful if you worked on the Research Protocol with help of the WRNMMC specialists

(Step 4)


Research Funding

Information on Research Funding is provided

By Dr. Kaminsky (Day 2, Module 9).


IMPORTANT TO REMEMBER !!!

Cue Card Reference:

You may not begin your research until

you have received

an IRB Approval and Approval Letter

from the Commander, WRNMMC.


The National Capital Region Military Medical Centers POCs:

Walter Reed National Military Medical Center DRP

(WRNMMC) ,

301 295-8239

[email protected]

Malcolm Grow Medical Center (MGMC),

IRB Office Cheryl James 240-857-8216

The Uniformed Services University (USU),

Research Office Maggie Pickerel 301-295-0819


Questions?


LO 2: Discus research at WRNMMC and it’s unique opportunities

Research at WRNMMC

WRNMMC’s goal remains to promote excellence in health care and militarily relevant research and human subject protection.

Department of Research Programs (DRP)

Human subject protection, research compliance and integrity; research administration, support, funding, publication and education.

https://nnmcintra/SiteDirectory/RCRS/default.aspx



Research at WRNMMC

Current research efforts at WRNMMC are ongoing:

head injury/TBI, stroke,

colon, breast cancer, leukemia and lymphoma,

investigational chemotherapy,

virtual colonoscopy,

diabetes management,

infectious disease,

dental imaging.

2011

Open Protocols at WRNMMCList is available on the Intranet at:https://nnmcintra/SiteDirectory/RCRS/Lists/Open%20Protocols/AllItems.aspx?View=%7b40123BB7%2dBE3A%2d4899%2d9423%2dB28C17B522E1%7d

Go to the Department of Research programs (DRP)) Intranet site at https://nnmcintra/SiteDirectory/RCRS/default.aspx

and click on Open Protocols


Questions?


LO 3: Know about research support available at WRNMMC.

WRNMMC Research Resources

Research Integrity Resources

Department of Research Programs (DRP),

Darnall Biomedical Learning Resource Center

Research Protocol/Publication Help,

Education/Mentoring Resources,

Protocol Outreach Program

ICEBERG,

IT tools.


Research Integrity Resources It is a policy of WRNMMC that all personnel will uphold highest principles of ethics

promoting research integrity and the responsible conduct of research (RCR).

RCR RESOURCES (web links):

TEXT

On Being A Scientist, National Academy of Sciences Committee on the Conduct of Science, 3rd Ed.,

Also available on the web at http://www.nap.edu/openbook.php?isbn=0309119707

DVD “THE LAB”

an interactive educational DVD has been developed by ORI for education regarding research misconduct.

Also available on the web at http://ori.dhhs.gov/TheLab,

RCRS site at https://nnmcintra/SiteDirectory/RCRS/default.aspx (under the RCRS links),

WEB RESOURCES PROVIDED ON THE DRP WEBSITE (INTRANET) at:https://nnmcintra/SiteDirectory/RCRS/default.aspx (under DRPLinks):

RESEARCH INTEGRITY

THE LAB: Interactive Movie on Research Misconduct

AVOID PLAGIARISM: 26 Guidelines at a glance

Research Ethics Resources provided by The Navy Medicine Institute

On Being a Scientist: A Guide to Responsible Conduct in Research: Third Edition (2009)

35

Research Integrity Resources (cont.)

ANTI-PLAGIARISM SOFTWARE TURNITIN

Web-based, http://turnitin.com/static/index.php

Free access available to the WRNMMC researchers.

Ask Ann Holman to help with Turnitin registration:

301-319-8411, [email protected]

Example of report : slide # 64

RESEARCH INTEGRITY DISCUSSIONS

ETHICS ROUNDTABLE: FRIDAYS (once/month, 1200-1300)

By Darnall Biomedical Learning Resource Center (Formerly Stitt Library)

https://nnmcintra/SiteDirectory/Darnall/Lists/Calendar/calendar.aspx


Department of Research Programs (DRP)

Cue Card Reference:


DRP information• DEPARTMENT OF RESEARCH PROGRAMS (DRP)

Bldg. 17, 3rd floor, suite 3C

DRP Chief LTC Klote, MD, MC [email protected]

301 295-8271 (no voicemail)

Questions: 301 295-8239,

or e-mail [email protected]

DRP Intranet https://nnmcintra/SiteDirectory/RCRS/default.aspx


Darnall Biomedical Learning Resource Center (DBLRC)

Bldg. 1, 3 rd floor, room 3458, ph. 301-295-1184

• Hours Monday-Thursday 0700-1730Friday 0700-1600

• Online Access is available via Athens.

Athens Registration : https://register.athensams.net/nnmc/

Ask Ann Holman to help with Athens registration

301-319-8411, [email protected]

• After Hours Access is availableContact Ann Holman at [email protected],

or visit the Circulation Desk to sign up for an access account,

and we'll contact you when your card is ready.

Library Access Card

2011 39Research Course

Darnall Biomedical Learning Resource Center (DBLRC)

Intranet

https://nnmcintra/SiteDirectory/Darnall/default.aspx

Stitt Internet

http://www.bethesda.med.navy.mil/professional/stitt_library

Questions: 301 295-1184

[email protected]


Research Protocol/Publication Help*Literature Search:

Comprehensive DB specialist: Mr. Fredric Simms, MLS

[email protected] 301 295-0080

Reference Librarian:

Kimberly D. Adams, M.A., M.S., M.L.S.

[email protected] 202-782-6547

*Statistical Data Analysis:

Audrey Chang, PhD 301-295-8263, [email protected]

Robin Howard, MA 301-295-8235 [email protected]

Francois O. Tuamokumo, PhD

301 319-8788 [email protected]

*These specialists provide hands-on workshops.


Education/Mentoring Resources

Head of Research Education: Marina Borovok, PhD

[email protected] 301 295-2876

Cue Card Reference:


Educational Resources

Research Course: 9 CME/CE, 2 days (0700-1200)

Next 2011 Research Course: November 8-9, 2011

Course PP slide show is available at: https://nnmcintra/SiteDirectory/RCRS/default.aspx

(under DRP Research School)


Educational Resources

Hands-on Research Preparation CourseApril-December, 2011, once/month, noon-1400.

Next Class is on September 27, 2011(session on IRB registration)

Location: Bldg. 57, ROOM 1214-B

Next Meeting Dates: 9/27, 10/13, 11/17, 12/15

This course provides participants with the practical skills required for writing a research proposal, completing research project, submitting research results to the WRNMMC Research Competition and a peer- reviewed journal in their specialty field.


Educational resources (cont.) PubMed Search Course

Developed and presented by the National Library of Medicine

2011 DATES: Tentative dates: 10/20, 12/2

TIME: 0900 - 1115

LOCATION: WRNMMC, Bldg 57, room 1214 B

COURSE GOAL

To provide guidelines for PubMed search, and teach researchers how to perform searches on their own.

REGISTRATION: PLEASE CONTACT Ms. Ann Holman: 301-319-8411, or via e-mail [email protected]


PubMed LINKS

The PubMed links are posted on the Intranet:

RCRS and Darnall Center websites

DRP website https://nnmcintra/SiteDirectory/RCRS/default.aspx

Darnall Center Website https://nnmcintra/SiteDirectory/Darnall/default.aspx



Hands-on Educational WORKSHOPS

Workshops are offered all year long at WRNMMC on a per-request basis.

Topics:

• Literature Search by Mr. Fredric Simms

• Statistical Analysis by Dr. Tuamokumo, Dr. Chang, and Ms. Howard

Please contact our specialists to schedule a workshop

2011

Protocol Outreach Program

To discuss research ideas and roadmap:– Clinician, statistician, regulatory reviewer, laboratory scientist– 45 min appointments for research ideas and roadmap. More information will be provided by Dr. Klote (Module 6), and Dr. Bernstein (Module 7).

• To schedule an appointment please contact Ms. Dale Gregory at

301 295-8239, or [email protected]


MENTORSHIP RESOURCESWRNMMC-USUHS mentorship initiative

• USUHSIf you are looking for a mentor in the specific areas of research, clinicalwork, education, professional development, please contact mentorshiprepresentatives at USUHS, and they will help you to find a mentor from theUSUHS mentorship network:

Andrew Waters, Ph.D ([email protected]) Chair of Research Committee

Dr. Jennifer Rusiecki ([email protected]) or Dr. Barbara Knollman ([email protected]) Co-chairs of Faculty Mentoring Committee

• WRNMMCIf you are looking for a mentor in the specific areas of military research,please contact research mentorship representative at WRNMMC:

Marina Borovok, PhD ([email protected])Head of Research Education.

On the web:

http://nnmcresearch.wikispaces.com/NNMC-USUHS+Mentorship+Project


MENTORSHIP RESOURCESInterdepartmental Collaborative Bethesda

Research Group


http://nnmcresearch.wikispaces.com/

MISSIONHelp WRNMMC to become a premier research organization in the Department of Defense.

Questions?



ResourcesIT tools: Turnitin

Turnitin is a Plagiarism Prevention Software.

Website: http://www.turnitin.com/static/index.html

• Plagiarism Prevention: Instantly identifies papers containing unoriginal material.

• Peer Review: Participants can review and respond to their colleagues' work online.

2011


Resources: IT toolsTurnitin http://turnitin.com/static/index.php

Example of report

2011


Resources: IT toolsIRBNet

www.irbnet.org

• IRBNet is the industry leading software, a robust set of electronic tools supporting the management, submission, review and oversight of our research protocols.

• IRBNet is secure, web-based, and easy to use.

2011


LO 4: Recognize IT tools that support research collaboration and communication from anywhere at any time. Collaborative E-applications Defense Connect Online (DCO) - Synchronous

Wikis - Asynchronous

Google Docs - Asynchronous

Best collaborative platform AKO/DKO

www.us.army.mil



Virtual meeting room DCO https://www.dco.dod.mil

2011

DCO– Defense Connect Online

• DCO– Defense Connect Online - provides DoD users worldwide with a second option for enterprise collaboration services.

• The DCO meeting room capabilities are: the DCO Portal, webconferencing, instant messaging, screen and file sharing, whiteboard, video and audio capabilities, hosting large meetings, and more.



Virtual meeting room DCO

2011 Live Training Schedule is available at:

https://www.dco.dod.mil/public/dsp/liveTraining.cfm

To participate in live training:

Go to

https://connect.dco.dod.mil/dcoliveremotetraining

Enter as a guest

2011


Wikis http://www.wikispaces.com/

A wiki is a website that can be edited by anyone who is granted permission.

It is simple and powerful knowledge sharing and

collaboration online tool that solves problems of Document management for a Team Project Management in an enterprise.

Other advantages of wiki: cheap or free, simple enough for non-technical employees to use.

Detailed instructions on how to create a wiki page are available at http://www.umich.edu/~umctdocs/Wiki.html

Wikis

Wiki Examples:

Wikipedia: http://en.wikipedia.org/wiki/Main_Page

WRNMMC ICEBERG: http://nnmcresearch.wikispaces.com/


WikisWiki at WRNMMC• ICEBERG (Interdepartmental Collaborative Bethesda Research

Group) http://nnmcresearch.wikispaces.com/



Google Docs https://www.docs.google.com

GoogleDocs is a free web-based collaborative software. It has applications of word processors, spreadsheet and presentations that are similar to Word, Excel and PowerPoint.

Several useful functions are: autosave, revision history and rename of the files.

It allows users to create

and edit documents online

while collaborating in

real-time with other users.


References: Hulley, S. et al.(2007), Designing Clinical Research, 2nd ed. Lippincott Williams &

Wilkins

On Being a Scientist: A Guide to Responsible Conduct in Research: Third Edition. (2009). Committee on Science, Engineering, and Public Policy,

National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. http://www.nap.edu/catalog/12192.html

• Goodnoe, E. (2005). How To Use Wikis For Business. The InformationWeek Business Technology Network. Retrieved March 11, 2010, from http://www.informationweek.com/news/management/showArticle.jhtml?articleID=167600331

• Pfeifer, S. (March 11, 2008). Wikis and Blogs. Presented at Administrative and

Instructional Uses of Technology, ED.851.609 (91) lecture at Johns Hopkins University.

• Riedel, C. (2008). Turnitin Integrates Plagiarism Tool into New Online Writing Service. Retrieved March 10, 2010, from http://campustechnology.com/articles/2008/09/turnitin-integrates-plagiarism-tool-into-new-online-writing-service.aspx

• Auga, N. (2006). Developing wikis to foster web-based learning communities: an iterative approach, International Journal of Web Based Communities (IJWBC), Vol.2, No.3. Retrieved March 12, 2010, from http://www.inderscience.com/offer.php?id=11761

Questions?



Thank You!My Contact Information:Marina Borovok, PhD

Head of Research EducationDepartment of Research ProgramsDirectorate for Professional EducationWalter Reed National Military Medical Center8901 Wisconsin Avenue,Bldg. 1, Rm. 4372,Bethesda, MD 20889

Phone: 301-295-2876Fax: 301-295-1490E-mail: [email protected]

2011

Documents

Walter Reed National Military Medical Center Directorate for Professional Education Department of Research Programs Introduction to Research at WRNMMC