Vol. 269, No. 51 The Journal of December 23, 1994

Biological Chemistry Copyright 0 1994 by the American Society for Biochemistry and Molecular Biology, Inc.

9650 Rockville Pike, Bethesda, MD 20814 U.S.A. ~~

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CONTENTS*

MINIREVIEW

Platelet-derived growth factor receptor signals. Lena Claesson-Welsh

COMMUNICATIONS

Interaction between FKBP12-rapamycin and TOR in- volves a conserved serine residue. Rodica Stan, Megan M. McLaughlin, Robert Cafferkey, Randall K. Johnson, Martin Rosenberg, and George I? Livi

A region in She distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. Pamela Blaikie, David Immanuel, Jun Wu, Nanxin Li, Vijay Yajnik, and Ben Margolis

Identiication of the major chromaffin granule-binding protein. chromobindin A, as the cytosolic chaperonin CCT (chaperonin containing TCP-1). Carl E. Creutz, Anthony Liou, Sandra L. Snyder, Amy Brownawell, and Keith Willison

Evidence for a self-catalytic mechanism of 2,4,5-tri- hydroxyphenylalanine quinone biogenesis in yeast cop- per amine oxidase. Danying Cai and Judith I? Klinman

The cytotoxic T cell proteinase granzyme B does not activate interleukin-lpeonverting enzyme. Alison J. Darmon, Nancy Ehrman, Antonio Caputo, Jocelyne Fujinaga, and R. Chris Bleackley

Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer. Husam M. Abu-Soud, Laura L. Yoho, and Dennis J. Stwhr

Isozyme-specific inhibition of protein kinase C by

Ellington, and Alexandra C. Newton RNA aptamers. Rick Conrad, Lisa M. Keranen, Andrew D.

Depletion of intracellular Cap' stores activates a maito- toxin-sensitive nonselective cationic current in &cells. Jennings E Worley III, Margaret S. McIntyre, Ben Spencer, and Iain D. Dukes

A helical element in the C-terminal domain of the N. plumbaginifolia F,p presequence is important for rec- ognition by the mitochondrial processing peptidase. Sara Sjoling, AnnaCarin Eriksson, and Elzbieta Glaser

ARTICLES

histocompatibility complex class I1 ligands in human fi- Induction of chemokine gene expression by mejor

broblast-like synoviocytes. Differential regulation by in-

Al-Daccak, Thomas J . Schall, and Walid Mourad terleukia-4 and dexamethasone. Khalil Mehindate, Reem

Biochemical and genetic characterization of PepF, an oligopeptidase from Lactococcus lactie. VPronique Monnet,

Jean-Claude Gripon Michde Nardi, Alain Chopin, Marie-Christine Chopin, and

Species difference in the G protein selectivity of the hu- man and bovine A,-adenosine receptor. Ralph Jockers, Maurine E. Linder, Martin Hohenegger, Christian Nanofi Brigitte Bertin, A. Donny Strosberg, Stefan0 Marullo, and Mi- chael Freissmuth

Purification and properties of protoporphyrinogen oxi- dase from the yeast Saccharomyces cerevisiae. Mitochon- drial location and evidence for a precursor form of the protein. Jean-Michel Camadro, Frangoise Thome, Nicole Brouillet. and Pierre Labbe

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Molecular cloning of a mammalian hyaluronidase re- veals identity with hemopexin, a serum heme-binding

Davies, Michael Stern, Ursula Muller-Eberhard, Robert Stem, protein. Li Zhu, Thomas J. Hope, Jackson Hall, Anthony

and Distram G. Parslow

stimulate system L amino acid transport in cultured vas- Glucose deprivation and acute cycloheximide treatment

and Murray R. Grigor cular smooth muscle cells. Boon Chuan Law, Ian K. Ross,

Smooth muscle caldesmon controls the strong binding interaction between actin-tropomyosin and myosin. Steven B. Marston, Iain D. C. Fraser, and Pia A. J. Huber

Discrete structural domains determine differential en-

transporter isoforms. Richard C. Hresko, Haruhiko Murata, doplasmic reticulum to Golgi transit times for glucose

Bess Adkins Marshall, and Mike Mueckler

Cloning, sequence analysis, and expression of the genes encoding the two subunits of the methylotrophic bacte-

and Richard P: Swenson rium W3A1 electron transfer flavoprotein. Dawei Chen

Biochemical mechanism of HIV-1 Vpr function. Oli-

Ling-Jun Zhao, Lilin Wang, Sampa Mukherjee, and Opendra gomerization mediated by the N-terminal domain.

Narayan

containing glycoprotein from the skin mucus of the loach, Characterization of a deaminated neuraminic acid-

Misgumwr anguillicaudahur. M a d o Kimum, Yoichim Hama, lbshihisa Sumi, Makw Asakawa, B. N. Namsinga Rao, Angela I? Horn, Su-Chen Li, Yu-lkh Li, and Hiroki Nakagawa

Analysis of an invariant cohrct.a~protein interaeon in thiamin diphosphate-dependent enzymes by sibdmxted mutagenesis. Glutamic acid 418 in trnnsketolase is essen-

Nilsson, Matti Nikkola, Ylva Lindgvist, Michuel Sundstriim, and tial for catalysis. Christer Wkner, Ludmilla Meshalkina, Ulrikn

Gunter Schneider

The stability of the molecular chaperonin cpn60 is af- fected by site-dmcted replacement of cysteine 618. Guang-Xiang Luo and Paul M. Horowitz

Isolation and characterization of HG80 cella resistant to

Marjaneh Berjis, Soha D. Idriss, Jiirgen S. Scheele, Modem nitroprusside-induced differentiation. Renate B. Pilz,

Suhasini, Lin Gao, Immo E. Scheffler, and Gerry R. Boss

Structural and functional analysis of NF-&. Determi-

Roland M. Schmid, Susanne Liptay, Jonathan C. Betts, and nants of DNAbinding specificity and protein interaction.

Gary J. Nabel

Molecular characterization of native and recombinant apolipoproteinA-I dimer. The introduction of an inte- chain disulfide b s e remarkably alters the physico- chemical properties of apolipoproteii A-I. Laurn Calnbresi, Giuseppe Vecchw, Renato Longhi, Elisabetta Gianozza, Gunnar

Anders Karktmm. lbrsten Sejlitz, Hans Ageland, Cesare R. Palm, Henrik Wadensten, Anette Hammarstrijm, Anders Olsson,

Sirtori, and Guidn Framschini

Investigation of the active site and the conformational stability of nucleoside diphosphate kinase by site-

Anthony A. Bominaar, and Michel W o n directed mutagenesis.Annemiek D. lkpper, Heike Dammann,

Functional and molecular characterization of the tran-

Karim Nayernia, Sabine Nieter, Hannelore Kremling, Heike scriptional regulatory region of the proacrosin gene.

Oberwinkler, and Wolfgang Engel

*The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1994) J. Biol. Chem. 269, 777-785, and reprints may be obtained from the editorial office.

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A secondary phosphorylation of CREB"' at Serl= is re- quired for the cAMF"mediated control of gene expres- sion. A role for glycogen synthase kinase4 in the control of gene expression. Carol J. Fiol, John S. Williams, Chin-Hua Chou, Q. May Wang, Peter J. Roach, and Ourania M. Andrisani

Desjardins, Julio E. Celis, Gerrit van Meer, Hans Dieplinger, Molecular characterization of phagosomes. Michel

Andrea Jahraus, Gareth Grifiths, and Lukas A. Huber

The major kidney A E 1 isoform does not bind ankyrin

amino acid residues of band 3. Yue Ding, Josep R Casey, (ANI(1) in uitro. An essential role for the 79 terminal

and Ron R. Kopito

Cleavage of the thyrotropin receptor does not occur at a classical subtilisin-related proprotein convertase endo- proteolytic site. Gregorio D. Chazenbalk and Basil Rapoport

Heat-stable inhibitors of "dependent protein

Harootunian, Stephen R. Adams, James Femmisco, Roger Y. kinase carry a nuclear export signal. Wei Wen, Alee I:

lkien, Judy L. Meinkoth, and Susan S. Thylor

A UGU sequence in the anticodon loop is a minimum requirement for recognition by Escherichia coli tRNA-

Hiroyuki Hori, Narihiko Yamazaki, Norihiro Okada, and guanine transglycosylase. Shigeko Nakanishi, Thkuya Ueda,

Kimitsuna Watanabe

Properties of recombinant mouse thrombospondin 2 ex-

M. ORourke, Yishua M. Dixit, and Deane E Mosher pressed in Spodoptera cells. Hui Chen, Jane Sottile, Karen

thyroid cells by increasing the regulatory subunit type 1,26Dihydroxyvitamin D, alters the effect of CAMP in

Anne Hansen Ree, Joe A. Sanduik, Kjetil Ibskbn, Brynjar E IIfS of the cAMP-dependent protein ki-. Jens I? Berg,

Landmark, Peter A. lbrjesen, and Egil Haug

Expression and characterization of human and chimeric human-Paracoccm denihificam electron transfer flavoproteins. Kevin R. Herrick, Denise Salazar, Stephen I.

E. Frerman Goalman, Gaetano Finocchiaro, Laura A. Bedzyk, and Fmnk

The regulation of capacitative calcium entry by calcium and protein kinase C in Xenopus oocytes. Carl C. H. Petersen and Michael J. Berridge

Dinerential effects of monoclonal antibodies on activat- ing transcription factocl and CAMP response element binding protein interactions with DNA. Dana J. Orten, Judith M. Strawhecker, Sam D. Sanderson, Danyang Huang, Michnel B. Prystowsky, and Steven H. Hinrichs

Identification of chloroplast envelope proteins in close physical proximity to a partially translocated chimeric

Kenton KO precursor protein. Chengbiao Wu, Fabian S. Seibert, and

Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1. ZTmothy W. Fawcett, Sherrie L. Sylvester, Kevin D. Sarge, Richard I. Morimoto, and Nikki J. Holbrook

Differential effect of cell-associated heparan sulfates on the binding of keratinocyte growth factor (KGF) and acidic fibroblast growth factor to the KGF receptor. Ronit Reich-Slotky, Dafna Bonneh-Barkay, Ester Shaoul, Berman Bluma, Carl M. Svahn, and Dina Ron

F'urified yeast translational initiation factor eIF-3 is an RNA-binding protein complex that contains the PRTl protein. lbtjana Naranda, Susan E. MacMillan, and John W. B. Hershey

Receptor-mediated endocytic uptake of methylglyoxal- modified serum albumin. Competition with advanced glycation end product-modified serum albumin at the advanced glycation end product receptor, Marie E. Westwood, Antony C. McLellan, and Paul J. Thornalley

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Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanis-

Nu-acetyllysine, and bovine serum albumin. Theodore W. tic study with Na-acetylarginine, Na-acetylcysteine, and

C. Lo, Marie E. Westwood, Antony C. McLellan, lkvor Selwood, and Paul J. Thornalley

lknnsition state structures for the hydrolysis of a-w glucopyranosyl fluoride by retaining and inverting reac-

Blanchard, and Edward J. Hehre tions of glycosylases. Yoshimasa Ihnaka, Wen nM, John S.

Second-site suppressor mutations at glycine 218 and histidine 246 in the a subunit of FIFO ATP synthase in Escherichia coli. Phillip E. Hartzog and Brian D. Cain

Electron transfer in the nitric-oxide syntheses. Charac- terization of L-arginine analogs that block heme iron reduction. Husam M. Abu-Sou& Paul L. Feldman, Pamela Clark, and Dennis J. Stuehr

The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a

Deist, Claire Hivroz, Alain Fischer, Henri Kom, and Daniel primary immunodeficiency. Michel Partiseti, Franqoise Le

Choquet

Stimulation of yeast adenylyl cyclase activity by lyso- phospholipids and fatty acids. Implications for the regu- lation of Weffector hction by lipids. Ross J. Resnick and Lubomlr lbmbgka

Expression of distinct fucosylated oligosaccharides and carbohydrate-mediated adhesion efficiency directed by two different a-1,3-fucosyltransferases. Comparison of E- and L-selectin-mediated adhesion. Shinobu Sueyoshi, Shigeru lkuboi, Ritsuko Sawada-Hirai, Uyenchi N. Dong, John El. Lowe, and Minoru Fukuda

Inhibition of HIV-1 reverse transcriptase by a quinazoli- none and comparison with inhibition by pyridinones. Differences in the rates of inhibitor binding and in synergistic inhibition with nucleoside analogs. Steven S. Carroll, Mark Stahlhut, James Gkib, and David B. Olsen

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-S,4-P, and PMIns-3,4,6-P,. Alex l'bker. Michael Meyer, K. Kishta Reddy, J. R. Falck, Rajindra Aneja, Sarla Aneja, Alejandro Parm, David J. Burns, Lawrence M. Ballas, and Lewis C. Cantley

Coexpression of cholesteryl ester transfer protein and defective apolipoprotein E in transgenic mice alters

pathogenesis of type III hyperlipoproteinemia. Sergio plasma cholesterol distribution. Implications for the

Fazw, Keith R. Marotti, Ya-Li Lee, Christine K. Castle, George W. Melchior, and Stanley C. Rall, Jr.

Rational reconstruction of the active site of a class M u glutathione S-transferase. Shu-ou Shan and Richard N. Armstrong

Identification of the urokinase receptor as an adhesion

Navaneetha Rao, Robert J. Drummond, Steven Rosenberg, and receptor for vitronectin. Ying Wei, David A. Waltz,

Harold A. Chapman

Molecular cloning of a proteolytic antibody light chain.

Anthony Rees, Alfonso n-umontano, Richard J. Massey, and Qing-Sheng Gao, Mei Sun. Sonia fiutyulkova, David Webster,

Sudhir Paul

The Cuenorhabditie elegans small GTP-binding protein RhoA is enriched in the nerve ring and sensory neurons during larval development. Weining Chen and Louis Lim

Amiio acid residues of the kringle-4 and kringle-6 do- mains of human plasminogen that stabilize their inter-

Nick Menhart, and Francis J. Castellino actions with w-amino acid ligands. Stephen G. McCanee,

Dynamin 1 antisense oligonucleotide treatment prevents

Enrique lbrre, Mark A McNiven, and Raul Urrutia neurite formation in cultured hippocampal neurons.

Rockville Pike, Bethesda, MD 20814. Volume 270 for 1995: Institutions: Urnted States, $900; Forei $1090. Stu~nWPostdoctoral FeIf%s: United The Journd ofBwlogicaZ Chemistry (ISSN 0021-9258) is published weekly by the American Society for Biochemist and Molecular Biolo Inc., 9650

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JOURNAL OF BIOLOGICAL CHEMISTRY at PO. Box 3000, Denville, NJ 07834, U.S.A. postage paid at Baltimore, MD 21202, USA. and at additional mailing offices. printed in the U.S.A POSTMASTER: Send address changes to THE

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Ganglioside G,,,, in cerebellar Purkinje cells. Its specific

ity and altered immunoreactivity in response to conjunc- absence in mouse mutants with Purkinje cell abnormal-

tive stimuli causing long-term desensitization. Shigeki Furuya, Fumitoshi Irie, n u t o m u Hashikawa, Kazutoshi Nakazawa, Akinori Kozakai, A k i m Hasegawa, Katsuko Sudo, and Yoshio Hirabayashi

The HLA-Bl4 peptide binding site can accommodate

Marianne DiBrino, Kenneth C. Parker, David H. Margulies, peptides with different combinations of anchor residues.

Joseph Shiloach, Richard V lbrner, William E. Biddison, and John E. Coligan

Clustering of the platelet Fcy receptor induces noncova- lent association with the tyrosine kinase p72.Y’. George W. Chacko, Anne-Marie Duchemin, K. Mark Coggeshall, Jeanne M. Osborne, John Z Brandt, and Clark L. Anderson

Activation of prothrombin by a novel membrane- associated protease. An alternative pathway for throm- bin generation independent of the coagulation cascade. Fuji0 Sekiya, Hide0 Usui, Keisuke Inoue, Kenji Fukudome, and lbkashi Morita

Protein kinase C 3 is associated with the mitotic appara- tus in primary cell cultures of the shark rectal gland. Riidiger W. Lehrich and John N. Forrest, J r

Structural organization of the human oxytocin receptor

Inazawa, Masahiko Takemum, Tomoyuki Kikuchi, Yasue gene. lbmoko Inoue, W a s h i Kimum, Chihiro Azuma, Johji

Kubota, Kazuhide Ogita, and Fumitaka Saji

Molecular model of the extracellular lectin-lie domain in CD69. Jiirgen Bajomth and Alejandro Aruffo

Annexin IV inhibits calmodulin-dependent protein kinase 11-activated chloride conductance. A novel mech- anism for ion channel regulation. Hsiao Chang Chan, Marcia A. Kaetzel, Anthony L. Gotter, John R. Dedman, and Deborah J. Nelson

Identification and characterization of LTBP-2, a novel latent transforming growth factor-p-binding protein. Anita Mor&, Anders Olofsson. Goran Stenman, Pelle Sahlin,

Miyazono, and Carl-Henrik Heldin Btsuto Kanzaki, Lena Claesson-Welsh, Peter ten Dijke, Kohei

%sine kinases regulate the cytoskeletal attachment of integrin (platelet glycoprotein IIWLIIa) and the cellular retractlon of fibrin polymers. S h o n e M. Schoenwaelder, S h u n I? Jackson, Yuping Yuan, Melvena S. Basdale, Hatem H. Satem, and Christina A. Mitchell

p66 tumor necrosis factor receptor. Cord Brakebusch, Structural requirements for inducible shedding of the

Eugene E. Varfolomeeu, Michael Batkin, and David Wallach

Functional expression of the human angiotensinogen gene in transgenic mice. Gongyu Yang, David C. Merrill, Mark W. Thompson, Jean E. Robillard, and Curt D. Sigmund

The mechanical properties of actin gels. Elastic modulus and filament motions. Paul A. Janmey, Sewn Huidt, Josef Kas, Dietmar Lerche, Anthony Maggs, Erich Sackmann, Manfred Schliwa, and Thomas I? Stossel

protein kinase pathway and induces formation of a Signaling through CD19 activates Vadmitogen-activated

CD19Navlphosphatidylinositol 3-kinase complex in hu- man B cell precursors. Wen-Kai Weng, Lisa Jaruis, and Bcker W. LeBien

Sequestration of muscarinic acetylcholine receptor m2

nase ( G W ) and attenuation by a dominant-negative subtypes. Facilitation by G protein-coupled receptor ki-

mutant of GRH2. Hirofumi Tsuga, Kimihiko Kameyama, lhtsuya Haga, Hitoshi Kurose, and Taku Nagao

Thapsigargin and Di-tert-butylhydroquinone induce synergistic stimulation of DNA synthesis with phorbol ester and bombesin in Swiss 3T3 cells. Amanda Charlesworth and Enrique Rozengurt

Molecular cloning and site-directed mutagenesis of glu- tathione S-transferase from Escherichia coli. The con- served tyrosyl residue near the N terminus is not essen-

Hideshi Inoue, and Kenji Takahashi tial for catalysis. Motohiko Nishida, Kwang-Hoon Kong,

Identification of an internal topogenic signal sequence in human band 3, the erythrocyte anion exchanger. Lisa I! Tam, n p W. Loo, David M. Clarke, and Reinhart A. l? Reithmeier

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Overlapping Egr-1 and Spl sites function in the regula-

gene. Dtsuji Shingu and Paul Bornstein tion of transcription of the mouse thrombospondin 1

like growth factor-I receptor with mutations in the tyro- Mitogenicity and transforming activity of the insulin-

sine kinase domain. Shiwei Li, Andres Ferber, Masahiko Miura, and Rennto Baserga

Enhancer activity of upstream hypersensitive site 2 of

Lynne V. Abnrzzo and Marc Reitman the chicken &globin cluster is mediated by GATA sites.

Bone morphogenetic protein-1 and a mammalian tolloid

transcripts which are differentially expressed in some homologue (mTld) are encoded by alternatively spliced

tissues. Kazuhiko Zbkaham, Gary E. Lyons, and Daniel S. Greenspan

The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of probvav. Shulnmit Katzau, Mary Sutherland, Graham Packham, Taolin Yi, and Arthur Weiss

Activation of mitogen-activated protein kinases by

muscle cells. Gadiparthi N. Rao, Arnold S. Baas, Wayne C. arachidonic acid and ita metabolites in vascular smooth

Alexnnder Glasgow, Thomas E. Eling, Marschull S. Runge, and R. Wayne

Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCFl. John A. Wemmie, Mark S. Szczypka, Dennis J. Thiele, and W. Scott Moye-Rowley

Evidence for a second receptor binding site on human prolactin. Vincent Gofin, Ingrid Struman, Wronique Mainfroid, Sandrina Kinet, and Joseph A. Martial

The sperm acrosomal matrix contains a novel member of the pentaxin family of calcium-dependent binding pro- teins. Thomas D. Noland, Bret B. Fridny, Maristelle Z Maulit, and George L. Gerton

1? Blobel Apexin, an acrosomal pentaxin. Martha S. Reid and Carl

The signaling pathway coupling epidermal growth fac- tor receptors to activation of p21’O.. Toshiyasu Sasaoka, W. John Langlois, J . Wayne Leitner, Boris Dmznin, and Jerrold M. Olefsky

A 30-base pair element is responsible for the myeloid- specific activity of the human neutrophil elastase pro- moter. Sampathkumar Srikanth and Thomas A. Rad0

Bone matrix decorin b i d s transforming growth factor-p and enhances its bioactivity. Yasuhiro Tokeuchi, Yoshinki Kodama, and Toshia Matsumoto

kinase activity of the human insulii proreceptor. Exon 11 enhances insulin binding affinity and tyrosine

Mohammad Pashmforoush, Yasunao Yoshimasa, and Donald I;: Steiner

ETS transcription factors regulate the expression of the gene for the human mitochondrial ATP synthase P- subunit. Josep A. Villenn, Immaculadn Martin, Octavi Viitas, Bru Cormand, Roser Iglesias, Dresa Mampel, Marta Gimlt, and Francesc Villarrqa

’Ibpoisomerase III, but not topoisomerase I, can support nascent chain elongation during theta-type DNAreplica- tion. Hiroshi Hinsa and Khnneth J. Marians

Regulation of macrophage receptor-bound plasmin by autoproteolysis. Domenick J. Falcone, Wolfgang Borth, l h o t h y A. McCaffky, Jean Mathew, and Kimberly MeAdam

Arginine becomes an essential amino acid after massive resection of rat small intestine. Yasuo Wakabayashi, Etsuko Yamada, Toshihide Yoshidai, and Hakuo Takahashi

tein. France Carrier, Martin L. Smith, hsoo Bae, Katherine E. Characterization of human GaddQs, a pM-regulated pro-

Kilpatrick, Ztmothy J . Lansing, Chaw-Yuan Chen, Marcy Engelstein, Steve H. Friend, W. David Henner, Tona M. Gdmer, Michael B. Kastan, and Albert J. Fornace, Jr.

Novel approach to molecular cloning and polynucleotide synthesis using vaccinia DNA topoisomerase. Stewart Shuman

Drosophila Rrpl. Isolation of mutants deficient in repair Single amino acid changes alter the repair specificity of

of oxidative DNA damage. Liya Gu, Shu-Mei Huang, and Miriam Sander

V

32693 Evidence for the uptake of a vitamin D analogue (OCT) by a human carcinoma and it8 effect of suppressing the

gene in vivo. Koichi Endo, Fumihiko Ichikawa, Yasushi transcription of parathyroid hormone-related peptide

Uchiyama, Kyoko Katsurnata, Hiroyuki Ohkawa, Kenji Kumnki, Etsuro Ogata, and Kyoji Ikeah

32700 In vivo isomerization of retinoic acids. Rapid isomer ex- change and gene expreesion. l&otum Kojimn, lbkayuki Fujinwri, Noriko Kiyotn, Yoshitaka Ibriya, lbru F u k u d a , lhkuya Ohashi, lbkoshi Sato, Yukihiro Yoshizawa, Ken-ichi Ihkeyama, Hiroshi Mano, Shoichi Mnsushige, and Shigeaki Kat0

ADDITIONS AND CORRECTIONS 32708 Drosophila kinesin motor domain extending to amino

acid position 392 is dimeric when expressed in Escherichia coli. Vol. 269 (1994) 18602-16607. Tlng-Guang Huang, Joseph Suhan, and David D. Hackney

32708 Specific residues at the top of transmembrane segment V and VI of the Neurokinin-1 receptor involved in binding

23959-23964. Ulrik Gether, Lars Nilsson, John A. Lowe III, and of the nonpeptide antagonist CP 98,346. Vol. 289 (1994)

Thue W. Schwartz

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MINIREVIEW

The Journal of Biological Chemistry

CONTENTS Arranged by Subject Categories

December 23, 1994

Platelet-derived growth factor receptor signals. Lena Claesson-Welsh

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

characterization of a deaminated neuraminic acid-

Misgurnus anguillicaudatus. Mariko Kimum, Yoichiru Hama, containing glycoprotein from the skin m u m of the loach,

lbshihisa Sumi, Makw Asakawa, B. N. Namsinga Raq Angela P. Home, Su-Chen Li, Yu-lbh Li, and Hiroki Nakagawa

Expression of distinct fucosylated oligosaccharides and carbohydrate-mediated adhesion efficiency directed by

E- and Gselectin-mediated adhesion. Shinobu Sueyoshi, two different a-1,3-fucosyltransferases. Comparison of

B. Lowe, and Minoru Fukuda Shigeru Ilpuboi, Ritsuko Sawada-Hirai, Uyenchi N. Dang, John

Ganglioside G,,,. in cerebellar Purkinje cells. Ita specific absence in mouse mutants with Purkinje cell abnormal- ity and altered immunoreactivity in response to conjunc- tive stimuli causing long-term desensitization. Shigeki Furuya, Fumitoshi Irie, l'kutomu Hashikawa, Kazutoshi Nakazawa, Akinori Kozakai, Akira Hasegawa, Katsuko Sudo, and Yoshw Himbayashi

CELL BIOLOGY AND METABOLISM A region in Shc distinct from the SH2 domain can bind

Pamela Blaikie, David Immanuel, Jun Wu, Nanxin Li, Vijay tyrosine-phosphorylated growth factor receptors.

Yajnik, and Ben Margolis

Depletion of intracellular Cas' stores activates a maito-

Jennings li: Worley III, Margaret S. Mclntyre, Ben Spencer, and toxin-sensitive nonselective cationic current in &cells.

Iain D. Dukes

Species difference in the G protein selectivity of the hu-

Maurine E. Linder, Martin Hohenegger, Christian NanoftP, man and bovine A,-adenosine receptor. Ralph Jockers,

Brigitte Bertin, A. Donny Strosberg, Stefan0 Marullo, and Mi- chael Freissmuth

Glucose deprivation and acute cycloheximide treatment stimulate system L amino acid transport in cultured vas-

and Murray R. Grigor cular smooth muscle cells. Boon Chuan Low, Ian K. Ross,

Discrete structural domains determine differential en- doplasmic reticulum to Golgi transit times for glucose transporter isoforms. Richard C. Hresko, Haruhiko Murata, Bess Adkins Marshall, and Mike Mueckler

Isolation and characterization of HG80 cells resistant to nitroprusside-induced differentiation. Renate B. Pilz, Marjaneh Berjis, Soha D. Idriss, Jiirgen S. Scheele, Modem Suhasini, Lin Guo, Immo E. Schefler, and Gerry R. Boss

Molecular characterization of phagosomes. Michel Desjardins, Julio E. Celis, Gerrit wan Meer, Hans Dieplinger, Andrea Jahraus, Gareth Grifiths, and Lukas A. Huber

The major kidney AEl isoform does not bind ankyrin (-1) in vitro. An essential role for the 79 -terminal amino acid residues of band 3. Yue Ding, J o Z R. Casey, and Ron R. Kopito

Heat-stable inhibitors of &"-dependent protein kinase carry a nuclear export signal. Wei Wen, Alec 111 Harootunian, Stephen R. Adams, James Feramisco, Roger Y Ilpien, Judy L. Meinkoth, and Susan S. Taylor

lgb-Dihydro@tamin D3 alters the effect of CAMP in thyroid cells by increasing the regulatory subunit type

Anne Hansen Ree, Joe A. Sanduik, Kjetil l'hskdn, Brynjar E IIB of the CAMP-dependent protein kinase. Jens P. Berg,

Landmark, Peter A. lbrjesen, and Egil Haug

The regulation of capacitative calcium entry by calcium

Petersen and Michael J . Berridge and protein kinase C in Xenopus oocytes. Carl C. H.

32279

32293

32327

32336

32358

32368

32380

32411

32435

32441

32446

32464

32479

32503

32514

Differential effect of cell-associated heparan sulfates on the binding of keratinocyte growth factor (KGF) and

Reich-Slotky, Dafna Bonneh-Barkny, Ester Shnoul, Berman acidic fibroblast growth factor to the KGF receptor. Ronit

Bluma, Carl M. Suahn, and Dina Ron

Receptor-mediated endocytic uptake of methylglyoxal- modified serum albumin. Competition with advanced glycation end product-modified serum albumin at the advanced glycation end product receptor. Marie E. Westwood, Antony C. McLellan, and Paul J . Thornalley

The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a

Deist, Claire Hiuroz, Alain Fischer, Henri Korn, and Daniel primary immunodeficiency. Michel Partiseti, Francoise Le

Choguet

Stimulation of yeast adenylyl cyclase activity by lyso- phospholipids and fatty acids. Implications for the regu- lation of Ras/effector function by lipids. Ross J . Resnick and Lubomtr lbm4Ska

Activation of protein kinase C family members by the novel polyphosphoinositides PtdInsQ,CP, and PtdIns-3,4,6-P3.Aler lbker, Michael Meyer, K. Kishta Reddy, J . R. Falck, Rajindra Aneja, Sarla Aneja, Alejandro Parra, David J. Burns, Lawrence M. Ballas, and Lewis C. Cantley

Coexpression of cholesteryl ester transfer protein and defective apolipoprotein E in transgenic mice alters plasma cholesterol distribution. Implications for the

Fazio, Keith R. Marotti, Ya-Li Lee, Christine K. Castle, George pathogenesis of type 111 hyperlipoproteinemia. Sergio

W. Melchior, and Stanley C. Rall, Jr.

Identification of the urokinase receptor as an adhesion receptor for vitronectin. Ying Wei, David A. Waltz, Nauaneetha Rao, Robert J. Drummond, Steven Rosenberg, and Harold A. Chapman

Dynamin 1 antisense oligonucleotide treatment prevents neurite formation in cultured hippocampal neurons. Enrique 'Ibrre, Mark A. McNiuen, and Raul Urrutia

Clustering of the platelet Fcy receptor induces noncova- lent association with the tyrosine kinase ~72". George W. Chacko, Anne-Marie Duchemin, K. Mark Coggeshall, Jeanne M. Osborne, John 111 Brandt, and Clark L. Anderson

Activation of prothrombin by a novel membrane- associated protease. An alternative pathway for throm- bin generation independent of the coagulation cascade. Fuji0 Sekiya, Hide0 Usui, Keisuke Inoue, Kenji Fukudome. and Takashi Morita

Protein kinase C Cis associated with the mitotic appara-

Riidiger W. Lehrich and John N. Forrest, Jr. tus in primary cell cultures of the shark rectal gland.

Annexin lV inhibits calmodulin-dependent protein kinase II-activated chloride conductance. A novel mech- anism for ion channel regulation. Hsiao Chang Chan, Marcia A. Kaetzel, Anthony L. Gotter, John R. Dedman, and Deborah J . Nelson

Tyrosine kinases regulate the cytoskeletal attachment of

cellular retraction of fibrin polymers. Simone M. integrin a,& (platelet glycoprotein IItdIIIa) and the

Schwnwaelder, Shaun P. Jackson, Yuping Yuan, Meluena S. lbasdnle, Hatem H. Salem, and Christina A. Mitchell

The mechanical properties of actin gels. Elastic modulus

Kas, Dietmar Lerche, Anthony Maggs, Erich Sackmann, Man- and filament motions. Paul A. Janmey, Seren Huidt, Josef

fred Schliwa, and Thomas I! Stossel

protein kinase pathway and induces formation of a Signaling through CD19 activates Vavlmitogen-activated

CD19Navlphosphatidylinositol 3-kinase complex in hu- man B cell precursors. Wen-Kai Weng, Lisa Jarvis, and ZLcker W. LeBien

Indicates a Communication

n

vii

32522

32528

32558

32579

32607

32615

32634

32639

32660

32667

32693

32700

32039

32043

32047

32051

32059

32063

32070

Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G proteincoupled receptor ki- nase (GRKZ) and attenuation by a dominant-negative mutant of GRKZ. Hirofumi Zbuga, Kimihiko Kameyama, lbtsuya Haga, Hitoshi Kurose, and lbku Nagao

Thapsigargin and Di-tert-butylhydroquinone induce synergistic stimulation of DNA synthesis with phorbol ester and bombesin in Swiss 3T3 cells. Amanda Charlesworth and Enrique Rozengurt

Mitogenicity and transforming activity of the insulin- like growth factor-I receptor with mutations in the tyro-

Mium, and Renato Baserga sine kinase domain. Shiwei Li, Andres Ferber, Masahiko

The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. Shulamit Katzau, Mary Sutherland, Graham Packham, Taolin yi, and Arthur Weiss

The sperm acrosomal matrix contains a novel member of the pentaxin family of calcium-dependent binding pro- tein~. Thomas D. Noland, Bret B. Friday, Maristelle I: Maulit, and George L. Gerton

Apexin. an acrosomal pentaxin. Martha S. Reid and Carl E? Blobel

Bone matrix decorin binds transforming growth factor-p and enhances its bioactivity. Yasuhiro lbkeuchi, Yoshiaki Kodama, and 'Ibshio Matsumoto

Exon 11 enhances insulin binding aff5nity and tyrosine

Mohammad Pashmforoush, Yasunao Yoshimasa, and Donald kinase activity of the human insulin proreceptor.

I? Steiner

Regulation of macrophage receptor-bound plasmin by autoproteolysis. Domenick J. Falcone, Wolfgang Borth, llmothy A. McCaffrey, Jean Mathew, and Kimberly McAdam

Arginine becomes an essential amino acid after massive resection of rat smal l intestine. Yasuo Wakabayashi, Etsuko Yamada, 'Ibshihide Yoshidai, and Hakuo Takahashi

Evidence for the uptake of a vitamin D analogue (OCT) by a human carcinoma and its effect of suppressing the transcription of parathyroid hormone-related peptide gene in uiuo. Koichi Endo, Fumihiko Ichikawa, Yasushi Uchiyama, Kyoko Katsumata, Hiroyuki Ohkawa, Kenji Kumaki, Etsuro Ogata. and Kyoji Ikeda

In uiw ieomerization of retinoic acids. Rapid isomer ex-

Fujimori, Noriko Kiyota, Yoshitaka lbriya, l ' b ~ Fukuda, lbkuya change and gene expression. Ryotaro Kojima, lhknyuki

Ohashi, lhkashi Sato, Yukihiro Yoshizawa, fin-ichi Takeyama, Hiroshi Mano, Sh ich i Masushige, and Shigeaki &to

ENZYMOLOGY Evidence for a self-catalytic mechanism of 2,4,&tri- hydroxyphenylalanine quinone biogenesis in yeast cop- per amine oxidase. Danying Cai and Judith II Klinman

The cytotoxic T cell proteinase granzyme B does not

Darmon, Nancy Ehrman, Antonio Caputo, Jocelyne Fujinaga, activate interleukin-lp-converting enzyme. Alison J.

and R. Chris Bleackley

Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer. Husam M. Abu-Soud, Laura L. Yoho, and Dennis J. Stuehr

RNA aptamers. Rick Conrad, Lisa M. Keranen, Andrew D. Isozyme-specific inhibition of protein kinase C by

Ellington, and Alexandra C. Newton

N. plumbaginifolia FIB presequence is important for rec- A helical element in the C-terminal domain of the

S a m Sjoling, AnnnCarin Eriksson, and Elzbieta Glaser ognition by the mitochondrial processing peptidase.

histocompatibility complex class I1 ligands in human fi- Induction of chemokine gene expression by major

broblast-like synoviocytes. Differential regulation by in-

Al-Daccak, Thomas J. Schnll, and Walid Mourad terleukin-4 and dexamethasone. Khalil Mehindate, Reem

Biochemical and genetic characterization of PepF, an

Michde Nardi, Alain Chopin, Marie-Christine Chopin, and oligopeptidase from Lactococcus lactis. Wronique Monnet,

Jean-Claude Gripon

32104

32144

32306

32318

32351

32373

32586

32035

32085

32239

32264

32313

32542

Smooth muscle caldesmon controls the strong binding

Steven B. Marston, Iain D. C. Fraser, and Pia A. J. Huber interaction between actin-tropomyosin and myosin.

Analysis of an invariant cofactor-protein interaction in thiamin diphosphatedependent enzymes by site-directed mutagenesis. Glutamic acid 418 in transketolaee is e e n - tial for catalysis. Christer Wikner, Ludmilla Meshnlkina, Ulrika Nilsson, Matti Nikkola, Ylva Lindqvist, Michael Sundstrijm, and Gunter Schneider

Transition state structures for the hydrolysis of a-LI- glucopyranosyl fluoride by retaining and inverting reac- tions of glycosylases. Yoshimasa Tanaka, Wen Tao, John S. Blanchnrd, and Edward J. Hehre

Electron transfer in the nitric-oxide synthases. Charac- terization of L-arginine analogs that block heme iron reduction. Husam M. A b u - S o d , Paul L. Feldman, Pamela Clark, and Dennis J. Stuehr

Inhibition of HIV-1 reverse transcriptase by a quinazoli- none and comparison with inhibition by pyridinones. Differences in the rates of inhibitor binding and in synergistic inhibition with nucleoside analogs. Steven S. Carroll, Mark Stahlhut, James Geib, and David B. Olsen

Rational reconstruction of the active site of a class Mu glutathione S-transferase. Shu-ou Shan and Richard N. Armstrong

Activation of mitogen-activated protein kinases by arachidonic acid and ita metabolites in vascular smooth muscle cells. Gadiparthi N. Rao, Arnold S. Baas, Wayne C.

Alexander Glasgow, Thomas E. Eling, Marschall S. Runge, and R. Wayne

MEMBRANES AND BIOENERGETICS

Identification of the mGor chromaffin granule-binding protein, chromobindin A, as the cytosolic chaperonin CCT (chaperonin containing TCP-1). Carl E. Creutz, Anthony Liou, Sandra L. Snyder, Amy Brownawell, and Keith Willison

Purification and properties of protoporphyrinogen oxi- dase from the yeast Saccharomyces cereuisiae. Mitochon- drial location and evidence for a precursor form of the

Brouillet, and Pierre Labbe protein. Jean-Michel Camadro, Fmnqoise Thome, Nicole

human-Paracoccus denihifians electron transfer fla- Expression and characterization of human and chimeric

man, Gaetano Finocchiaro, Laura A. Bedzyk, and Frank E. voproteins. Kevin R. Herrick, Denise Salazar, Stephen I. Good-

Frerman

Identification of chloroplast envelope proteins in close physical proximity to a partially translocated chimeric precursor protein. Chengbiao Wu, Fabian S. Seibert, and Kenton KO

Second-site suppressor mutations at glycine 218 and his- tidine 245 in the n subunit of F,Fo ATP synthase in Escherichia coli. Phillip E. Hartzog and Brian D. Cain

Identification of an internal topogenic signal sequence in human band 3, the erythrocyte anion exchanger. Lisa Y Tam, n p W. Loo, David M. Clarke, and Reinhart A. E Reithmeier

NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS

32027 Interaction between FKBP12-rapamycin and TOR in-

McLaughlin, Robert Cafferkey, Randall K. Johnson, Martin volves a conserved serine residue. Rodica Stan, Megan M.

Rosenbrg, and George I? Liui

32092 Molecular cloning of a mammalian hyaluronidase re- veals identity with hemopexin, a serum heme-binding

Dauies, Michael Stern, Ursula Muller-Eberhard, Robert Stern, protein. Li Zhu, Thomas J. Hope, Jackson Hall, Anthony

and Distram G. Parslow

32131 Biochemical mechanism of HIV-1 Vpr function. Oli- gomerization mediated by the N-terminal domain. Ling-

Namyan Jun Zhao, Lilin Wang, Sampa Mukherjee, and Opendra

Indicates a Communication

vlll ...

32162

32181

32187

32221

32254

32272

32286

32394

32451

32497

32551

32565

32572

32592

32626

32649

32655

32672

32678

Structural and functional analysis of NF-KB. Determi-

Roland M. Schmid, Susanne Liptay, Jonathan C. Betts, and nants of DNAbinding specificity and protein interaction.

Gary J. Nabel

Functional and molecular characterization of the tran-

Karim Nayernia, Sabine Nieter, Hannelore Kremling, Heike scriptional regulatozy region of the proacrosin gene.

Oberwinkler, and Wolfgang Engel

A secondary phosphorylation of CREB"' at S e P is re- quired for the "mediated control of gene expres- sion. A role for glycogen synthase kinase4 in the control of gene expression. Carol J. Fwl, John S. Williams, Chin-Hua Chou, Q. May Wang, Peter J. Roach, and Ourania M. Andrisani

A UGU sequence in the anticodon loop is a minium requirement for recognition by Escherichia coli tRNA- guanine transglycosylase. Shigeko Nakanishi, lhkuya Uedu, Hiroyuki Hori, Norihiko Yamazaki, Norihiro Okadu, and Kimitsuna Watanabe

Differential effects of monoclonal antibodies on activat- ing transcription factor-1 and CAMP response element binding protein interactions with DNA. Dana J. Orten,

Michnel B. Prystowsky, and Steven H. Hinrichs Judith M. Strawheckel; Sam D. Sanderson, Danyang Huang,

Effects of neurohormonal stress and aging on the

Fawcett, Sherrie L. Sylvester, Kevin D. Sarge, Richard I. activation of mammalian heat shock factor 1. Timothy W.

Morimoto, and Nikki J. Holbrook

Purified yeast translational initiation factor em-3 is an RNA-binding protein complex that contains the PRTl

B. Hershey protein. Tatjana Naranah, Susan E. MacMillan, and John W.

The Cuenorhahiitis ekgans small GTP-binding protein RhoA is enriched in the nerve ring and sensory neurons during larval development. Weining Chen and Louis Lim

Structural organization of the human oxytocin receptor

Inuzawa, Masahiko lhkemum, l'bmoyuki Kikuchi, Ymue gene. Ilbmoko Inoue, Washi Kimura, Chihiro Azuma, Johji

Kubota, Kazuhide Ogita, and Fumitaka Saji

Functional expression of the human angiotensinogen

Mark W. Thompson, Jean E. Robillard, and Curt D. Sigmund gene in transgenic mice. Gongyu Yang, David C. Merrill,

Overlapping Egr-1 and Spl sites function in the regula- tion of transcription of the mouse thrombospondin 1 gene. ntsuji Shingu and Paul Bornstein

Enhancer activity of upstream hypersensitive site 2 of

Lynne V. Abruzzo and Marc Reitman the chicken 6-globin cluster is mediated by GATA sites.

Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues. Kazuhiko Takahara, Gary E. Lyons, and Daniel S. Greenspan

Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1. John A. Wemmie, Mark S. Szczypka, Dennis J . Thiele, and W. Scott Moye-Rowley

A 30-base pair element is responsible for the myeloid- specific activity of the human neutrophil elastase pro- moter. Sampathkumar Srikanth and Thomas A. Rad0

gene for the human mitochondrial ATP synthase 6- ETS transcription factors regulate the expression of the

subunit. Josep A. Villena, Immaculada Martin, Octavi Viks, Bru Cormand, Roser Iglesias, Dresa Mampel, Marta Gimlt, and Francesc Villarroya

Topoisomerase III, but not topoisomerase I, can support nascent chain elongation during theta-type DNA replica- tion. Hiroshi Hiasa and Kenneth J. Marians

Characterization of human Gadd46, a p63-regulated pro- tein. France Carrier, Martin L. Smith, Imca Bae, Katherine E. Kilpatrick, Timothy J. Lansing, Chaw-Yuan Chen, Marcy Engelstein, Steve H. Friend, W. David Henner, lbna M. Gilmer, Michael B. Kastan, and Albert J. Fornace, Jr

Novel approach to molecular cloning and polynucleotide

Shuman synthesis using vaccinia DNA topoisomerase. Stewart

32120

32151

32168

32175

32209

32226

32299

32389

32405

32426

32457

32469

32488

32536

32598

32621

32685

PROTEIN CHEMISTRY AND STRUCTURE

Cloning, sequence analysis, and expression of the genes encoding the two subunits of the methylotrophic bacte- rium W3A1 electron transfer flavoprotein. Dawei Chen and Richard I? Swenson

The stability of the molecular chaperonin cpn60 is af- fected by site-directed replacement of cysteine 618. Guang-Xiang Luo and Paul M. Horowitz

Molecular characterization of native and recombinant apolipoprotein A-I,, dimer. The introduction of an i n t e ~ chain disulfide bridge remarkably altera the physico- chemical properties of apolipoprotein A-I. h u m Calabresi, Giuseppe Vecchw, Renato Longhi, Elisabetha Gianozza, Gunnar

Anders firlstrijm, l'brsten Sejlitz, Hans Ageland, Cesare R. Palm, Henrik Wadensten, Anette Hammarstrijm, Anders Olsson,

Sirtori, and Guido Fmnceschini

Investigation of the active site and the conformational stability of nucleoside diphosphate kinase by site- directed mutagenesis.Annemiek D. lkpper, Heike Dammann, Anthony A. Bominuar, and Michel Vkron

Cleavage of the thyrotropin receptor does not occur at a classical subtilisin-related proprotein convertase endo- proteolytic site. Gregorio D. Chazenbalk and Basil Rapoport

Properties of recombinant mowe thrombospondin 2 ex- pressed in Spodoptera cells. Hui Chen, Jane Sottile, Karen M. ORourke, Vishva M. Dixit, and Deane E: Masher

Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanis- tic study with Na-acetylarginine, Nu-acetylcysteine, and Na-acetyllysine, and bovine serum albumin. Theodore W.

and Paul J. Thornalley C. Lo, Marie E. Westwood, Antony C. McLellan, l k u o r Selwood,

Molecular cloning of a proteolytic antibody light chain.

Anthony Rees, Alfonso Damontano, Richard J. Massey, and Qing-Sheng Gao, Mei Sun, Sonia Qutyulkova, David Webster,

Sudhir Paul

Amino acid residues of the kringle-4 and kringle-6 do- mains of human plasminogen that stabilize their inter- actions with 0-amino acid ligands. Stephen G. McCanee, Nick Menhart, and Francis J. Castellino

The HLA-B14 peptide binding site can accommodate peptides with different combinations of anchor residues. Marianne DiBrino, Kenneth C. Parker, David H. Margulies, Joseph Shiloach, Richard V. ILrner, William E. Biddison. and John E. Coligan

Molecular model of the extracellular lectin-lie domain in CD69. Jiirgen Bajorath and Alejandro Aruffo

Identification and characterization of LTBP-2, a novel latent transforming growth factor-&binding protein. Anita Mort%, Anders Olofsson, &ran Stenman, Pelle Sahlin,

Miyazono, and Carl-Henrik Heldin lktsuto Kanzaki, Lena Claesson-Welsh, Peter ten Dyke, Kohei

p55 tumor necrosis factor receptor. Cord Brakebusch, Structural requirements for inducible shedding of the

Eugene E. Varfolomeev, Michael Batkin, and David Wallach

Molecular cloning and site-directed mutagenesis of glu- tathione S-transferase from Escherichia coli. The con- served tyrosyl residue near the N terminus is not essen- tial for catalysis. Motohiko Nishida, Kwang-Hoon Kong, Hideshi Inoue, and Kenji lhkahashi

Evidence for a second receptor binding site on human prolactin. Vincent Gofin, Ingrid Struman, Vkroniqw Mainfroid, Sandrina Kinet, and Joseph A. Martial

The signaling pathway coupling epidermal growth fac-

John Langlois, J. Wayne Leitner, Boris Draznin, and Jerrold M. tor receptors to activation of ~21"". l'bshiyasu Sasaoka, W.

Olefsky

Single amino acid changes alter the repair specificity of Drosophila Rrpl. Isolation of mutants deficient in repair of oxidative DNA damage. Liya Gu, Shu-Mei Huang, and Miriam Sander

ix

32708 Drosophila kinesin motor domain extending to 32708 Specific residues at the top of transmembrane segment V amino acid position 892 is dimeric when expressed and VI of the Neurokinin-1 receptor involved in binding in Escherichia coli. Vol. 269 (1994) 16602-16607. of the nonpeptide antagonist CP 96,348. Vol. 269 (1994) Ting-Guang Huang, Joseph Suhan, and David D. 2396!#-23964. Ulrik Gether, Lars Nilsson, John A. Lowe III, and Hackney Thue W. Schwartz

Abruzzo, Lynne V., 32565 Abu-Soud, Husam M.,

Adams, Stephen R., 32214 Ageland, Hans, 32168 Al-Daccak, Reem, 32063 Alexander, R. Wayne, 32586 Anderson, Clark L., 32435 Andrisani, Ourania M.,

Aneja, Rajindra, 32358

Armstrong, Richard N., Aneja, Sarla, 32358

-0, Alejandro, 32457

Azuma, Chihiro, 32451 Asakawa, Makio, 32138

Baas, Arnold S. , 32586 Bae, Insoo, 32672 Bajorath, Jiirgen, 32457 Ballas, Lawrence M., 32358 Baserga, Renato, 32558 Batkin, Michael, 32488 Bedzyk, Laura A., 32239 Berg, Jens P., 32233 Bejis, Majaneh, 32155 Berridge, Michael J., 32246 Bertin, Brigitte, 32077 Beth, Jonathan C., 32162

Blaikie, Pamela, 32031 Biddison, William E., 32426

Bleackley, R. Chris, 32043 Blanchard, John S., 32306

Bluma, Berman, 32279 Blobel, Carl P., 32615

Bominaar. Anthonv A,.

32047,32318

32187

32373

32175

32279

- .

Bonneh-Barkay, Dafna,

Bornstein, Paul, 32551 Borth, Wolfgang, 32660 Boss, Gerry R., 32155 Brakebusch, Cord, 32488

Brouillet, Nicole, 32085 Brandt, John T., 32435

Brownawell, Amy, 32035 Burns, David J., 32358

Cafferkey, Robert, 32027 Cai, Danying, 32039 Cain, Brian D., 32313 Calabresi, Laura, 32168 Camadro, Jean-Michel,

Cantley, Lewis C., 32358 Caputo, Antonio, 32043

Carroll, Steven S., 32351 Carrier, France, 32672

Casey, Joseph R., 32201 Castellino, Francis J., 32405 Castle, Christine K., 32368 Celis, Julio E., 32194 Chacko, George W., 32435 Chan, Hsiao Chang, 32464 Chapman, Harold A., 32380 Charlesworth. Amanda.

32085

32528

32209 Chazenbalk, Gregorio D.,

Chen,-Chaw-Yuan, 32672

Chen, Hui, 32226 Chen, Dawei, 32120

Chen, Weining, 32394

Chopin, Alain, 32070 Chopin, Marie-Christine,

Choquet, Daniel, 32327 Chou, Chin-Hua, 32187 Claesson-Welsh, Lena,

Clark, Pamela, 32318 Clarke, David M., 32542

Coligan, John E., 32426 Coggeshall, K. Mark, 32435

Conrad, Rick, 32051 Cormand, Bru, 32649 Creutz, Carl E., 32035

Dammann, Heike, 32175 Dang, Uyenchi N., 32342 Darmon, Alison J., 32043 Davies, Anthony, 32092 Dedman, John R., 32464 Desjardins, Michel, 32194 DiBrino, Marianne, 32426

Ding, Yue, 32201 Dieplinger, Hans, 32194

Dixit, Vlshva M., 32226 Draznin, Boris, 32621 Drummond, Robert J.,

32070

32023,32469

32380 Duchemin, Anne-Marie,

32435 Dukes, Iain D., 32055

Eling, Thomas E., 32586 Ehrman, Nancy, 32043

Ellington, Andrew D., 32051 Endo, Koichi, 32693 Engel, Wolfgang, 32181 Engelstein, Marcy, 32672 Eriksson, AnnaCarin, 32059

Falck, J. R., 32358 Falcone, Domenick J.,

Fawcett, Timothy W., 32272 Fazio, Sergio, 32368

Feramisco, James, 32214 Feldman, Paul L., 32318

Ferber, Andres, 32558 Finocchiaro, Gaetano, 32239 Fiol, Carol J., 32187 Fischer, Alain, 32327 Fornace, Albert J., Jr.,

Forrest, John N., Jr., 32446 Franceschini, Guido, 32168 Fraser, Iain D. C., 32104 Freissmuth, Michael, 32077

Friday, Bret B., 32607 Frerman, Frank E., 32239

Friend, Steve H., 32672 Fujimori, Takayuki, 32700 Fujinaga, Jocelyne, 32043 Fukuda, Minoru, 32342 Fukuda, Tom, 32700 Fukudome, Kenji, 32441 Furuya, Shigeki, 32418

Gao, Lin, 32155 Gao, Qing-Sheng, 32389 Geib, James, 32351

Gether, Ulrik, 32708 Gerton, George L., 32607

Gianazza, Elisabetta, 32168 Gilmer, 'Ibna M., 32672

32660

32672

AUTHOR INDEX

Giralt, Marta, 32649 Glaser, Elzbieta, 32059 Glasgow, Wayne C., 32586 Goffin, Vincent, 32598 Goodman, Stephen I., 32239 Gotter, Anthony L., 32464 Greenspan, Daniel S., 32572 Griffiths, Gareth, 32194 Grigor, Murray R., 32098 Gripon, Jean-Claude, 32070 Gu, Liya, 32685

Hackney, David D., 32708 Haga, Tatsuya, 32522 Hall, Jackson, 32092 Hama, Yoichiro, 32138 Hammarstriim, Anette,

Hamtunian, Alec T., 32214 Hartzog, Phillip E., 32313 Hasegawa, Akira, 32418 Hashikawa, 'Igutomu, 32418 Haug, Egil, 32233 Hehre, Edward J., 32306

Henner, W. David, 32672 Heldin, Carl-Henrik, 32469

Hemck, Kevin R., 32239 Hershey, John W. B., 32286 Hiasa, Hiroshi, 32655 Hinrichs, Steven H., 32254

Hivroz, Claire, 32327 Hirabayashl, Yoshio, 32418

Hohenegger, Martin, 32077 Holbmk, Nikki J., 32272 Hope, Thomas J., 32092 Hori, Hiroyuki, 32221 Home, Angela P., 32138 Horowitz, Paul M., 32151 Hresko, Richard C., 32110 Huang, Danyang, 32254 Huang, Shu-Mei, 32685 Huang, TingGuang, 32708 Huber, Lukas A,, 32194 Huber, Pia A. J., 32104 Hvidt, Seren, 32503

Ichikawa, Fumihiko, 32693 Idriss, Soha D., 32155 Iglesias, Roser, 32649 Ikeda, Kyoji, 32693 Immanuel, David, 32031 Inazawa, Johji, 32451 Inoue, Hideshi, 32536 Inoue, Keisuke, 32441 Inoue, lbmoko, 32451 Irie, Fumitoshi, 32418

Jackson, Shaun P., 32479 Jahraus, Andrea, 32194 Janmey, Paul A,, 32503 Jawis, Lisa, 32514 Jockers, Ralph, 32077 Johnson, Randall K., 32027

Kaetzel, Marcia A,, 32464 Kameyama, Kimihiko,

Kanzaki, Tetsuto, 32469 Karlstrom, Anders, 32168 U s , Josef, 32503 Kastan, Michael B., 32672 Kato, Shigeaki, 32700 Katsumata, Kyoko, 32693 Katzav, Shulamit, 32579

32168

32522

Keranen, Lisa M., 32051 Kikuchi, lbmoyuki, 32451 Kilpatrick, Katherine E.,

Kimura, Mariko, 32138 Kimura, Tadashi, 32451 Kinet, Sandrina, 32598 Kiyota, Noriko, 32700 Klinman, Judith P., 32039 KO, Kenton, 32264 Kodama, Yoshiaki, 32634

Kong, Kwang-Hoon, 32536 Kojima, Ryotaro, 32700

Kopito, Ron R., 32201 Korn, Henri, 32327 Kozakai, Akinori, 32418 Kremling, Hannelore, 32181 Kubota, Yasue, 32451 Kumaki, Kenji, 32693 Kurose, Hitoshi, 32522

Labbe, Pierre, 32085 Landmark, Brynjar F.,

Lansing, Timothy J., 32672 Langlois, W. John, 32621

LeBien, Tucker W., 32514 Le Deist, Francoise, 32327 Lee, Ya-Li, 32368 Lehrich, Riidiger W., 32446 Leitner, J. Wayne, 32621 Lerche, Dietmar, 32503 Li, Nanxin, 32031 Li, Shiwei, 32558 Li, Su-Chen, 32138 Li, Yu-Teh, 32138 Lim, Louis, 32394 Linder, Maurine E., 32077 Lindqvist, Ylva, 32144 Liou, Anthony, 32035 Liptay, Susanne, 32162 Livi, George P., 32027 Lo, Theodore W. C., 32299 Longhi, Renato, 32168

Low, Boon Chuan, 32098 Loo, Tip W., 32542

Lowe, John B., 32342 Lowe, John A,, 111, 32708

Luo, Guang-Xiang, 32151 Lyons, Gary E., 32572

MacMillan, Susan E., 32286 Maggs, Anthony, 32503

Mampel, Teresa, 32649 Mainfroid, Vkronique, 32598

Mano, Hiroshi, 32700 Margolis, Ben, 32031 Margulies, David H., 32426 Marians, Kenneth J., 32655 Marotti, Keith R., 32368 Marshall, Bess Adkins,

Martial, Joseph A., 32598 Marston, Steven B., 32104

Martin, Immaculada, 32649 Marullo, Stefano, 32077 Massey, Richard J., 32389 Masushige, Shoichi, 32700 Mathew, Jean, 32660 Matsumoto, lbshio, 32634 Maulit, Maristelle T., 32607

McCaffrey, Timothy A., McAdam, Kimberly, 32660

32672

32233

32110

32660

McCanee, Stephen G.,

McIntyre, Margaret S., 32405

32055 McLaughlin, Megan M.,

McLellan, Antony C., 32293,

McNiven, Mark A., 32411

Meinkoth, Judy L., 32214 Mehindate, Khalil, 32063

Menhart, Nick, 32405 Melchior, George W., 32368

Meshalkina, Ludmilla, Memll, David C., 32497

Meyer, Michael, 32358 Mitchell, Christina A,,

Miyazono, Kohei, 32469 Miura, Masahiko, 32558

Monnet, Veronique, 32070 Moren, Anita, 32469

Morita, Takashi, 32441 Morimoto, Richard I., 32272

Mosher, Deane F., 32226 Mourad, Walid, 32063 Moye-Rowley, W. Scott,

Mueckler, Mike, 32110 Mukhejee, Sampa, 32131 Muller-Eberhard, Ursula,

Murata, Haruhiko, 32110

Nabel, Gary J., 32162 Nagao, Taku, 32522 Nakagawa, Hiroki, 32138 Nakanishi, Shigeko, 32221 Nakazawa, Kazutoshi,

Naranda, Tatjana, 32286 Nanoff, Christian, 32077

Narayan, Opendra, 32131 Nardi, Michele, 32070 Nayernia, Karim, 32181 Nelson, Deborah J., 32464 Newton, Alexandra C.,

Nieter, Sabine, 32181 Nikkola, Matti, 32144 Nilsson, Lars, 32708 Nilsson, Ulrika, 32144 Nishida, Motohiko, 32536 Noland, Thomas D., 32607

Oberwinkler, Heike, 32181 Ogata, Etsuro, 32693 Ogita, Kazuhide, 32451 Ohashi, Takuya, 32700 Ohkawa, Hiroyuki, 32693 Okada, Norihiro, 32221 Olefsky, Jerrold M., 32621 Olofsson, Anders, 32469 Olsen, David B., 32351

ORourke, Karen M., 32226 Olsson, Anders, 32168

Orten, Dana J., 32254 Osborne, Jeanne M., 32435

Palm, Gunnar, 32168 Packham, Graham, 32579

Parker, Kenneth C., 32426 Parra, Alejandro, 32358

32027

32299

32144

32479

32592

32092

32418

32051