Vol. 268, No. 4 The Journal of February 5, 1993

Biological Chemistry Copyright 0 1993 by the American Society for Biochemistry and Molecular Biology, Inc.

428 East Preston St., Baltimore, MD 21202 U.S.A.

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CONTENTS*

MINIREVIEW Helicase-catalyzed DNA unwinding. Timothy M. Lohrnan

COMMUNICATIONS In vivo generation of an adenylylcyclase isoform with a half-molecule motif. Shuichi Katsushika, Jun-ichi Ka- wabe, Charles J . Homcy, and Yoshihiro Ishikawa

Protein-tyrosine kinase ~ 7 2 ' ~ ' i s activated by thrombin and is negatively regulated through Ca2+ mobilization in platelets. Takanobu Taniguchi, Hiroshi Kitagawa, Satoshi Yasue, Shigeru Yanagi, Keiko Sakai, Momoyo Asahi, Shinj! Ohta, Fumito Takeuchi, Shun-ichi Nakamura, and Hirohel Yamamura

Different isozymes of protein kinase C mediate feed- back inhibition of phospholipase C and stimulatory sig- nals for exocytosis in rat RBL-2H3 cells. Koichiro Ozawa,

Michael A. Beaven Koji Yamada, Marcelo G. Kazanietz, Peter M. Blumberg, and

tion domain of human p53 and the TATA box-binding Direct interaction between the transcriptional activa-

protein. Ray Truant, Hua Xiao, C. James Ingles, and Jack Greenblatt

T4-phage deoxycytidylate deaminase is a metallopro-

Moore, Ruth E. Silversmith, Gladys F. Maley, and Frank Maley tein containing two zinc atoms per subunit. John T.

Formyl peptide receptor chimeras define domains in- volved in ligand binding. H. Daniel Perez, Richard Holmes.

Jolley, and William H. Andrews Laura R. Wander, Robert R. Adams, Warren Manzana, Duffy

An iron-sulfur center and a free radical in the active

Etienne Mulliez, Marc Fontecaue, Jacques Gaillard, and Peter anaerobic ribonucleotide reductase of Escherichia coli.

Reichard

Adenovirus-mediated augmentation of cell transfection with unmodified plasmid vectors. Kunihiko Yoshirnura, Melissa A. Rosenfeld, Prem Seth, and Ronald G. Crystal

Cell cycle-specific activation of the PTK72 protein- tyrosine kinase in B lymphocytes. Debra L. Burg, Marietta L. Harrison, and Robert L. Geahlen

ARTICLES Guanosine tetraphosphate inhibits protein synthesis in vivo. A possible protective mechanism for starvation

and Judith W. Zyskind stress in Escherichia coli. Amy L. Suitil, Michael Cashel,

active intestinal peptide receptor glycosylation. Alter- Structural and functional analysis of the human vaso-

ation of receptor function by wheat germ agglutinin. J a n Chochola, Catherine Fabre, Catherine Bellan, Jose Luis, Sylvain Bourgerie, Brigitte Abadie, Serge Champion, Jacques Marualdi, and Assou El Battari

stance P antagonist CP-96,345. Bruce S. Sachais, R. Mi- Molecular basis for the species selectivity of the sub-

chael Snider, John A. Lowe III, and James E. Krause

Expression of rat liver reduced glutathione transport in Xenopus laevis oocytes. Jose Carlos Ferndndez-Checa, Jian-R. Yi, Carmen Garcia-Ruiz, Zorica Knezic, Stanley M. Tahara, and Neil Kaplowitz

Trafficking of wild-type and an endoproteolytic-site

tein. Laurie J. Goodman, Steven R. Kain, and Gary L. mutant of the mouse mammary tumor virus glycopro-

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Molecular cloning and sequence of a novel ommo- chrome-binding protein cDNA from an insect, Man- duca sexta. Gloria M. Yepiz-Plascencia, Chaumei Ho, Ralph R. Martel, and John H. Law

Differential effects of brefeldin A on transport of secretory and lysosomal proteins. Ger J . Strous, Peter uan Kerkhof, Gerrit van Meer, Simon Rijnboutt, and Willem Stooroogel

N-Myristylation of the catalytic subunit of CAMP-de- pendent protein kinase conveys structural stability. Wes Yonemoto, Maria L. McGlone, and Susan S. Taylor

sialoglycan unit in a carbohydrate-rich glycopeptide Structural studies of a novel type of tetraantennary

isolated from the fertilized eggs of Indian Medaka fish, Oryzias melastigma. Tomohiko Taguchi, Akira Seko, Ken Kitajima, Sadako Inoue, Takashi Iwamatsu, Kay-Hooi Khoo, Howard R. Morris, Anne Dell, and Yasuo Inoue

Import and assembly of the j3-subunit of chloroplast coupling factor 1 (CF,) into isolated intact chloroplasts. Geoffrey G. Chen and Andre T. Jagendorf

G. mediates hormonal inhibition of the calcium pump in liver plasma membranes. Catherine Jouneaux, Yves Audigier, Paul Goldsmith, Franqoise Peeker, and Sophie Lotersztajn

The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin. Jia Ye, Charles T. Esmon, and Arthur E. Johnson

Actin-binding peptides obtained from the C-terminal 24-kDa fragment of porcine aorta smooth muscle my- osin subfragment-1 heavy chain. Tsuyoshi Katoh and Fumi Morita

Agonist-stimulated internalization of the thyrotropin- releasing hormone receptor is dependent on two do- mains in the receptor carboxyl terminus. Daniel R. Nus- senzueig, Marcos Heinflink, and Marvin C. Gershengorn

The mechanism of aluminum-independent G-protein activation by fluoride and magnesium. 31P NMR spec- troscopy and fluorescence kinetic studies. Bruno An- tonny, Muppalla Sukumar, Joelle Bigay, Marc Chabre, and Tsutomu Higashijima

Quantitative characterization of the structure of rho- dopsin in disc membrane by means of Fourier transform infrared spectroscopy. Dauid Garcia-Quintana, Pere Gar- riga, and Joan Manyosa

Enhanced stimulation of myosin subfragment 1 ATPase activity by addition of negatively charged residues to

Root, Carl Miller, Emil Reisler, and Peter A . Rubenstein the yeast actin NHz terminus. R. Kimberley Cook, Douglas

The x-ray crystal structure refinements of normal human transthyretip and the amyloidogenic Val-30 4

Met variant to 1.7-A resolution. Jean A. Hamilton, Larry K. Steinrauf, Bradford C. Braden, Juris Liepnieks, Merrill D. Benson, Gosta Holmgren, Ola Sandgren, and Lars Steen

X-ray crystal structure of the Ala-109 Thr variant of human transthyretin which produces euthyroid hy- perthyroxinemia. Larry K. Steinrauf, Jean A. Hamilton, Bradford C. Braden, Jill R. Murrell, and Merrill D. Benson

NMR studies of phospholipase C hydrolysis of phospha- tidylcholine in model membranes. Shastri P. Bhamidipati and James A. Hamilton

* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1993) J. Biol. Chem. 268, 745-753, and reprints may be obtained from the editorial office.

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Novel activity of a yeast ligase deletion polypeptide. Evidence for GTP-dependent tRNA splicing. Shawn K.

son, and Chris L. Greer Westaway, Heather G. Belford, Barbara L. Apostol, John Abel-

Multiple nucleotide cofactor use by yeast ligase in tRNA splicing. Evidence for independent ATP- and GTP- binding sites. Heather G. Belford, Shawn K. Westaway, John Abelson, and Chris L. Greer

The activity-controlling phosphorylation site is not the same in the four acidic ribosomal proteins from Sac- charomyces cereuisiae. Tatjana Naranda, Miguel Remacha, and Juan P. G. Ballesta

Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I. Michael J . McGuire, Peter E. Lipsky, and Dwain L. Thiele

A trisaccharide acceptor analog for N-acetylglucosa- minyltransferase V which binds to the enzyme but ster- ically precludes the transfer reaction. Shaheer H. Khan, Suzanne C. Crawley, Osamu Kanie, and Ole Hindsgaul

Initial interaction between fibrin and tissue plasmino-

on fibrin(ogen) is important for t-PA activity. Elzbieta gen activator (t-PA). The Gly-Pro-Arg-Pro binding site

Kaczmarek, Myoung H. Lee, and Jan McDonagh

Alternative substrates for calf intestinal adenosine de- aminase. A pre-steady-state kinetic analysis. David J . T. Porter and Thomas Spector

Deletion mutagenesis of high molecular weight kini- nogen light chain. Identification of two anionic surface binding subdomains. Satya P. Kunapuli, Raul A. DeLa Cadena, and Robert W . Colman

Contribution of specific cis-acting elements to activity

gulis and Suend 0. Freytag of the mouse pro-a2(1) collagen enhancer. Robert J . Po-

Interactive intermediates are formed during the urea

Butler unfolding of rhodanese. Paul M. Horowitz and Michael

scriptional regulator Leu3 of yeast. Ji- Ying Sze and Gun- Purification and structural characterization of tran-

ter B. Kohlhaw

Independent binding of interleukin- l a and interleukin- 18 to type I and type I1 interleukin-1 receptors. Jennifer Slack, Catherine J. McMahan, Stephen Waugh, Kenneth Schooley, Melanie K. Spriggs, John E. S ins , and Steven K. Dower

Analysis of transcriptional stimulation by recombinant Oct proteins in a cell-free system. Arnd Annweiler, Stefan Zwilling, Robert A. Hipskind, and Thomas Wirth

Iron content of human 5-lipoxygenase, effects of mu-

Zhang, Birger Lind, Olof R d m a r k , and Bengt Samuelsson tations regarding conserved histidine residues. Ying-Yi

Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins. Ikra-

Erickson muddin Aukhil, Paritosh Joshi, Yingzhuo Yan, and Harold P.

gans. Structural organization and inducible, cell-spe- The novel metallothionein genes of Caenorhabditis ele-

cific expression. Jonathan H. Freedman, Lee W . Slice, Den- nis Dixon, Andrew Fire, and Charles S. Rubin

Biochemical analysis of human immunodeficiency vi- rus-1 reverse transcriptase containing a mutation at position lysine 263. J . Louise Martin, Jeanne E. Wilson, Eric S. Furfine, Samuel E. Hopkins, and Phillip A. Furman

Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione perox-

R. Steven Esworthy idase, GSHPx-GI. Fong-Fong Chu, James H. Doroshow, and

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Tumor necrosis factor stimulates the synthesis and se- cretion of biologically active nerve growth factor in non-neuronal cells. Akira Hattori, Eiko Tanaka, Katsuhito Murase, Nobuhiro Ishida, Yuji Chatani, Masafumi Tsujimoto, Kyozo Hayashi, and Michiaki Kohno

A second form @ isoform) of nucleoside diphosphate kinase from rat. Isolation and characterization of com- plementary and genomic DNA and expression. Nobuko Shimada, Naoshi Ishikawa, Yoko Munakata, Tosifusa Toda, Kazutada Watanabe, and Narimichi Kimura

Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses com- plements the genetic lesion. Joan M. Moehring, Noel M. Inocencio, Barbara J . Robertson, and Thomas J . Moehring

Chronic ethanol treatment increases expression of in- hibitory G-proteins and reduces adenylylcyclase activ- ity in the central nervous system of two lines of ethanol- sensitive mice. Gary S. Wand, Anna Mae Diehl, Michael A . Leuine, David Wolfgang, and Sanjay Samy

Expression of the a-myosin heavy chain gene in the heart is regulated in part by an E-box-dependent mech- anism. Jeffery D. Molkentin, Rebecca S. Brogan, Shawn M. Jobe, and Bruce E. Markham

Purification and characterization of a membrane- bound protein carboxyl methyltransferase from rat kidney cortex. Dominique Boiuin, Denis Gingras, and Rich- ard Beliueau

Interaction of reconstituted high density lipoprotein discs containing human apolipoprotein A-I (ApoA-I) variants with murine adipocytes and macrophages. Evidence for reduced cholesterol efflux promotion by ApoA-1(Pr0'~~ + Arg). Arnold uon Eckardstein, Graciela Castro, Iwona Wybranska, Nathalie Theret, Philippe Ducha- teau, Nicolas Duuerger, Jean-Charles Fruchart, Gerard Ail- haud, and Gerd Assmann

In uiuo DNA-protein interactions at the divergent mer- cury resistance (mer ) promoters. I. Metalloregulatory

Anne 0. Summers protein MerR mutants. Valerie Liurelli, Ike Whan Lee, and

In uiuo DNA-protein interactions at the divergent mer- cury resistance (mer) promoters. 11. Repressor/activa- tor (MerR)-RNA polymerase interaction with merOP mutants. Ike Whan Lee, Valerie Liurelli, Soon-Jung Park, Paul A. Totis, and Anne 0. Summers

Synthesis of CMP-deaminoneuraminic acid (CMP- KDN) using the CTP:CMP-3-deoxynonulosonate cyti- dylyltransferase from rainbow trout testis. Identifica- tion and characterization of a CMP-KDN synthetase.

Inoue, Fumio Ito, Frederic A. Troy, and Yasuo Inoue Takaho Terada, Shinobu Kitazume, Ken Kitajima, Sadako

Gene-specific DNA repair of interstrand cross-links

tial. Florence Larminat, Weiping Zhen, and Vilhelm A. Bohr induced by chemotherapeutic agents can be preferen-

by the insulin-like growth factor-I (IGF-I) receptor. Role of tyrosine kinase activity in signal transduction

Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (aIR-3). Hisanori Kato, Teresa N . Faria, Bethel Stannard, Charles T . Roberts, Jr., and Derek LeRoith

Domain structure of an N-ethylmaleimide-sensitive fu- sion protein involved in vesicular transport. Mitsuo Ta- gaya, Duncan w. Wilson, Michael Brunner, Nancy Arango, and James E. Rothman

two cases of type IV osteogenesis imperfecta (01). Ad- Serine for glycine substitutions in type I collagen in

ditional evidence for a regional model of 01 pathophys- iology. Joan C. Marini, Mary Beth Lewis, Qin Wang, Kathleen J. Chen, and Bonnie M. Orrison

Enzymatic analysis of two HIV-1 reverse transcriptase mutants with mutations in carboxyl-terminal amino acid residues conserved among retroviral ribonucleases H. Silke Volkmann, Birgitta Maria Wohrl, Margaret Tisdak, and Karin Moelling

Baltimore, MD 21202, U.S.A. Volume 268 for 1993 United States, $710 other countries, $860. Single copy: United States, $24.00: other countries, $28.00, Special subscrlptlon rates are The Journal ofBiologica1 Chemistry (ISSN 0021-9258) is published three times per month by the American Society for Biochemistry and Molecular Biology, Inc., 428 East,Preston Street,

available to members, graduate students, and postdoctoral fellows for personal use only. Qualifying forms are available from the ASBMB Office, 9650 Rockville Pike, Bethesda. MD 20814. Second class postage paid at Baltimore, MD 21202, U.S.A. and at additional mailing offices. Send address changes to The Journaf of Biological Chemistry at 428 East Preston Street, Baltimore, MD 21202, U.S.A.

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Reverse transcriptases from bacterial retrons require specific secondary structures at the 5'-end of the tem- plate for the cDNA priming reaction. Tadashi Shimamoto, Mei- Yin Hsu, Sumiko Inouye, and Masayori Inouye

ras protein activity is essential for T-cell antigen recep- tor signal transduction. Cosima T. Baldari, Adriana Heguy, and John L. Telford

Transformation of the signal peptide/membrane anchor domain of a type I1 transmembrane protein into a cleav-

Lemay, Philippe Crine, and Guy Boileau able signal peptide. Patrice Roy, Christine Chatellord, Guy

I and C-protein in isolated myocardial cells is associated Protein kinase C-mediated phosphorylation of troponin

with inhibition of myofibrillar actomyosin MgATPase. Richard C. Venema and J. F. Kuo

boxyl-terminal domains. Identical ligand binding prop- Two isoforms of the EP3 receptor with different car-

erties and different coupling properties with Gi pro- teins. Yukihiko Sugimoto, Manabu Negishi, Yasunori Hay- ashi, Tsunehisa Namba, Akiko Honda, Akiko Watabe, Masakazu Hirata, Shuh Narumiya, and Atsushi Ichikawa

Fidelity of 429 DNA polymerase. Comparison between

Jose A . Esteban, Margarita Salas, and Luis Blonco protein-primed initiation and DNA polymerization.

phenyl 1,2-dioxygenase. Lindsay D. Eltis, Birgit Hofmann, Purification and crystallization of 2,3-dihydroxybi-

Hans-Jiirgen Hecht, Heinrich Liinsdorf, and Kenneth N. Timmis

Cell biological studies with monoclonal and polyclonal

demonstrate participation of the kinase in mitogenic antibodies against human casein kinase I1 subunit 0

signaling. Peter Lorenz, Rainer Pepperkok, Wilhelm Ansorge, and Walter Pyerin

binding domains and C termini of plasma membrane Alternative splicing of exons encoding the calmodulin-

Scott E. Burk, and Gary E. Shull CaZ+-ATPase isoforms 1,2, 3, and 4. Timothy P. Keeton,

AP- 1 antagonizes thyroid hormone receptor action on the thyrotropin &subunit gene. Fredric E. Wondisford, Hans J . Steinfelder, Michelle Nations, and Sally Radouick

The primary structure of rat ribosomal protein L23a.

of genes for mammalian and yeast ribosomal proteins The application of homology search to the identification

Katsuyuki Suzuki and Ira G. Wool and a correlation of rat and yeast ribosomal proteins.

sion of p75 but not p55 TNF receptors, and both recep- Tumor necrosis factor (TNF) up-regulates the expres-

tors mediate, independently of each other, up-regula- tion of transforming growth factor a and epidermal

Roeder, Manfred Brockhaus, Heinz-Giinter Thiele, and Wolff growth factor receptor mRNA. Holger Kalthoff, Christian

Schmiegel

Interactions of phage P22 tailspike protein with GroE

Brunschier, Martina Danner, and Robert Seckler molecular chaperones during refolding in uitro. Rainer

early gene promoter by the viral early transcription Recruitment of vaccinia virus RNA polymerase to an

factor. Jing Li and Steuen S. Broyles

Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. Ching-Shwun Lin, Taesun Park, Zong Ping Chen, and John Leauitt

Characterization of the human L-plastin gene promoter

Ping Chen, Taesun Park, Karabi Ghosh, and John Leauitt in normal and neoplastic cells. Ching-Shwun Lin, Zong

cytochrome b6 suggests novel targeting pathways. An- The specific subcellular localization of two isoforms of

tonello D'Arrigo, Ernest0 Manera, Renato Longhi, and Nica Borgese

plasmic reticulum that affect functional association Identification of regions in the CaZ+-ATPase of sarco-

zydlowski, Michihiko Tada, and Dauid H. MacLennan with phospholamban. Toshihiko Toyofuku, Kazimierz Kur-

phosphatase containing SH2 domains. Zhizhuang Zhao, Purification and characterization of a protein tyrosine

Patrice Bouchard, Curtis D. Diltz, Shi-Hsiang Shen, and Ed- mond H. Fischer

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Disulfide bond requirements for assembly of the plate- let glycoprotein Ib-binding domain of von Willebrand

Zauerio M. Ruggeri, and Jerry Ware factor. Hiroyuki Azuma, Tomohiro Hayashi, Judith A. Dent,

Sarcina ventriculi synthesizes very long chain dicar- boxylic acids in response to different forms of environ- mental stress. Seunho Jung, Susan E. Lowe, Rawle I. Hol- lingsworth, and J . Gregory Zeikus

Molecular characterization of the family of the N-

Koki Moriyoshi, Hidemitsu Sugihara, Kazuhiro Sakurada, methyl-D-aspartate receptor subunits. Takahiro Ishii,

Hiroshi Kadotani, Mineto Yokoi, Chihiro Akazawa, Ryuichi Shigemoto, Noboru Mizuno, Masayuki Masu, and Shigetada Nakanishi

Biosynthesis of the vasoactive lipid monobutyrin. Cen-

M. Spiegelman tral role of diacylglycerol. William 0. Wilkison and Bruce

Exogenous, but not endogenous, glucocorticoid recep- tor induces glutamine synthetase gene expression in early stage embryonic retina. Haiying Zhang and Anthony P. Young

Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth. Purification and biological properties. Ken-ichi Naruo, Chisako Seko, Ken-ichi Kuroshima, Etsuya Matsutani, Reiko Sasada, Tatsuya Kondo, and Tsutomu Kurokawa

Pancreatic-type phospholipase A2 stimulates prosta- glandin synthesis in mouse osteoblastic cells (MC3T3-

Kish im , Jun Ishizaki, and Hitoshi Arita E l ) via a specific binding site. Masahiro Tohkin, Junji

Binding of protein S to Factor Va associated with in- hibition of prothrombinase that is independent of acti- vated protein C. Mary J . Heeb, Rolf M. Mesters, Guido Tans, Jan Rasing, and John H. Grif f in

The conserved H1 domain of the type I1 keratin 1 chain plays an essential role in the alignment of nearest neighbor molecules in mouse and human keratin 1/ keratin 10 intermediate filaments at the two- to four- molecule level of structure. Peter M. Steinert and Dauid A. D. Parry

Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identi- fies critical residues for its cofactor activity. Mariko Nagashima, Erik Lundh, Jill C. Leonard, John Morser, and John F. Parkinson

Coupling muscle electrical activity to gene expression via a CAMP-dependent second messenger system. Ken- neth G. Chahine, Edgardo Baracchini, and Daniel Goldman

High level thrombospondin 1 expression in two NIH 3T3 cloned lines confers serum- and anchorage-inde- pendent growth. Valerie P. Castle, Xianglan Ou, Karen O'Rourke, and Vishua M. Dixit

A novel short consensus repeat-containing molecule is related to human complement factor H. Christine Skerka,

F. Zipfel Sabine Kiihn, Kathrin Giinther, Klaus Lingelbach, and Peter

A specific CCAAT-binding protein, CBP/tk, may be involved in the regulation of thymidine kinase gene expression in human IMR-90 diploid fibroblasts during senescence. Jong Hwei Pang and Kuang Y u Chen

Characterization of the nuclear and cytoplasmic com- ponents of the lymphoid-specific nuclear factor of ac-

Katharine S. Ullman, and Gerald R. Crabtree tivated T cells (NF-AT) complex. Jeffrey P. Northrop,

Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and ~185"~~ ' . Evi- dence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of hu-

Mohammed Shoyab, and Kurt Stromberg man epithelial cells. Gibbes R. Johnson, Bhanu Kannan,

Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the Pl+P2+ TP2 locus. James E. Nelson and Stephen A. Krawetz

Mammalian poly(A)-binding protein 11. Physical prop-

Lustig, Paul Jeno, and Patrik Maurer erties and binding to polynucleotides. Elmar Wahle, Ariel

vi

2946 Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-gly- coprotein antagonists. Cynthia E. Herzog, Maria Tsokos, Susan E. Bates, and Antonio T. Fojo

2953 Metabolism-based transformation of myoglobin to an oxidase by BrCC13 and molecular modeling of the oxi- dase form. Yoichi Osawa, John F. Darbyshire, Peter J. Stein- bach, and Bernard R. Brooks

2960 Differential transforming abilities of non-secreted and secreted forms of human fibroblast growth factor-1.

Kurt A. Engleka, Thomas Sayers, Robert H. Wiltrout, and Reza Forough, Xi Zhan, Martin MacPhee, Stanley Friedman,

Thomas Maciag

2969 Purification of a SO-kDa protein (band VII) from car- diac sarcoplasmic reticulum. Identification as calnexin and localization of casein kinase I1 phosphorylation sites. Steven E. Cala, Corinne Ulbright, Jeffry S. Kelley, and Larry R. Jones

2976 Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2- 23.1. Edmond Crouch, Kevin Rust, Rosalie Veile, Helen Donis-Keller, and Leonard Grosso

2984 Expression of biologically active recombinant keratin- ocyte growth factor. Structure/function analysis of amino-terminal truncation mutants. Dina Ron, Donald P. Bottaro, Paul W . Finch, Dauid Morris, Jeffrey S. Rubin, and Stuart A. Aaronson

2989 Expression of native and truncated forms of the human integrin al subunit.,Roger Briesewitz, Marc R. Epstein, and Eugene E. Marcantonlo

2997 Inhibition by barbiturates of the binding of Bm3R1 re ressor to its o erator site on the barblturate-lnduc- i b g c tochrome 8450eM-3 gene of Bacillus megaterium. Gwo-8hyuan Shaw and Armand J. Fulca

3005 Dissqciatipn of pp70 ribosomal protein S6 kinase from

cytes. Diane C. Fingar, Sharon F. Hausdorff, John Blenis, msulln-stlmulated glucose transport in 3T3-Ll adipo-

and Morris J. Birnbaum 3009 Neutrophil activation by nascent FimH subunits of type

1 fimbriae purified. from the periplasm of Escherichia coli. Ru mder Tewarl, Jennlfer I. MacGregor, Teruo Ikeda, J. Russell h t t le , Scott J . Hultgren, and Soman N . Abraham

ADDITIONS AND CORRECTIONS 3016 Serum regulates Na+/H* exchange in Caco-2 cells by a

mechanism which is dependent on F-actin. Vol. 267 1992) 956-962.Alastair J . M . Watson, SusanLeuine, Mark

3016 Isolation, ex ression, and mutation of a rabbit skeletal

terminus of fast skeletal muscle troponln I In Its blolog- muscle cDNA) clone for Troponin I. The rol? qf the NH2

Sheng, Bo-Sheng Pan, Todd E. Md r, and James D. Potter ical activity. Vol. 267 (1992 25407-25413. Zelcn

3016 Nitric oxide-induced S-nitrosylation of glyceralde- hyde-3-phosphate dehydrogenase inhibits enzymatic

Vol. 267 (1992) 24929-24932. LuisMolinay Vedia, Brad activity and increases endogenous ADP-ribosylation.

McDonald, Bryan Reep, Bernhard Briine,, Mauricio Di Siluio, Timothy R. Bdltar, and Eduardo G. Lapetcna

6 ’ onowctz, and Marshall H. Montrose

t

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Vol. 268, No. 4 The Journal of Biological Chemistry

CONTENTS Arranged by Subject Categories

February 5, 1993

. I

MINIREVIEW Helicase-catalyzed DNA unwinding. Timctthy M. Lohman

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

Structural studies of a novel type of tetraantennary sialogtycan unit. in a carbohydrate-rich glycopeptide isolated from the fertilized eggs of Indian Medaka fish,

Kilajima, Sadako lnoue, Takashi Iuamatsu, Kay-Hooi Khoo, Oryaias melastigma. ‘Ibmohiko Taguchi, Akira Seko, Ken

Haword R. Morris, Anne I)ell, and Yasuo lnoue

A trisaccharide aeceptor analog for N-acetylglucosa- minyltransferase V which binds to the enzyme but ster- ically precludes the transfer reaction. Shahcvr H. Khan, Suzanne C. Crauky, Osamu Kanie, and Ole Hindsgaul

Synthesis of CMP-deaminoneuraminic acid (CMP- KDN) using the CTP:CMP-3-deoxynonulosonate cyti- dylyltransferase from rainbow trout testis. Tdentifica- tion and characterization of a GMP-KDN synthetase. Takaho Teradu. .Shin~jbu Kitazume, Ken Kitajima, S ~ d a k ~ j Intiur?. E’umio Ito, E’rederic A. Troy, and Yawo Inouc

Sarcina ventriculi synthesizes very long chain dicar- boxylic acids in response to different forms of environ- ment.al stress. Seunho Jung Susan E. Lowe, Raude I. Hoi- l ~ ? ~ g . ~ ~ ~ ~ ~ / ~ ~ h , and J. Gregorv Zcikus

CELL BIOLOGY AND METABOLISM Protein-tyrosine kinase p?2eyk is activated by thrombin and is negatively regulated through Caz+ mobilization in platelets. ‘Ihkanobu Taniguchi, Hiroshi Kitagawn, Satoshi

Ohta, E’umito Takeuchi, Shun-ichi Nakarnura, and Hiroh.ei Yasue. Shigeru Yanagi, Keiko ,Sakai, Momoyo Asahi, Shinji

Yomamura

Different isozymes of protein kinase C mediate feed- back inhibition of phospholipase C and stimulatory sig- nals for exocytosis in rat RBL-2H3 cells. Koic-hiro Ozawa, Koji Yamada, Marcelo G. Kazanietz, Peter M. Blumberg, and Micha[,~ A . Hcaoen

Formyl peptide receptor chimeras define domains in- volved in ligand binding. H. Daniel Perez, Richard Holmes,

Jolley, and ~ ~ i l l j u m H. Andreuw Laura K. Vilander, Robert K . Adams, Warren Manzana, Duff?/

Cell cycle-specific activation of the PTK72 protein- tyrosine kinase in B lymphocytes. Debra I,. Burg, Marietta L. Harrison. and Robert L. Geahlen

W29 Trafficking of wild-type and an endoproteolytic-site mutant of the mouse mammary tumor virus glycopro- tein. 1,aurie J. Goodman, Steven X . Kain, and Gary L. Firestonr,

2341 Differential effects of brefeldin A on transport of secretory and lysosomal proteins. Ger J . Strous, Peter van KerkhoJ. Clferrit van Meer, Simon Rijnboutt, and Willem StoorLJOgel

2368 G. mediates hormonal inhibition of the calcium pump in liver plasma membranes. Catherine Jou.neaux, Yves Audigier, Paul Goldsmith, Francoise J.’ecker, and Sophie Lotersztajn

2389 Agonist-stimulated internalization of the thyrotropin- releasing hormone receptor is dependent on two do-

senzveig, Marcos Heinflink, and Maruirt C. Gershengorn mains in the receptor carboxyl terminus. Daniel R. Nus-

2431 NMR studies of phospholipase C hydrolysis of phospha- tidylcholine in model membranes. Shastri P. ha midi pa ti and James A. Hamilton

2458 Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I. I~iohael J. M e ~ u i r e , Peter E. Lipsky, and I h a i n L. Thiele

ndicates a Communication

2513

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2577

2590

2595

’655

2662

2705

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2836

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2865

Independent binding of interleukin-la and interleukin- 18 to type I and type I1 interleukin- I receptors. Jenni/er Slack, ~ ~ a ~ h e r ~ n e J. McMahan, Stephen ~ a u g h , Kenneth

Dower Schooley, Melanie K. Spriggs, John E. Sims, and Steven K.

Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins. Ikra- ~ u d d i n auk hi^, Paritosh Joshi, Yingzhuo Tan, and Harold P. Erickson

Tumor necrosis factor stimulates the synthesis and se- cretion of biologically active nerve growth faetor in non-neuronal cells. Akira Hattori, Eiko Tanaka, Katsuh.i~o Murase, Nobuh~ro Ishida, Yuji Chatani, M ~ ~ a / u r n i Tsujimoto, Kyozo Hayashi, and Michiaki Kohno

Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses com- plements the genetic lesion. Joan M. ~ o e h r i ~ ~ , Noel M. Inocencio, Barbara J. Robertson, and Thomas J. Moehring

Chronic ethanol treatment increases expression of in- hibitory G-proteins and reduces adenylylcyclase activ- ity in the central nervous system of two lines of ethanol- sensitive mice. Gary S. Wand, Anna Mae Diehl, Michael A. Levine, David Wol/gang, and Sanjay Samy

Role of tyrosine kinase activity in signal transduction

Characterization of kinase-defieient IGF-I receptors by the insulin-like growth factor-I (IGF-I) reeeptor.

and the aetion of an IGF-I-mimetic antibody (aIR-3). Hisanori Katm, Teresa N. Faria, Bethel Stannard, Charles T. Roberts, Jr., and Derek LeKoith

Domain structure of an ~ - e t h y l m ~ e i m i d e - ~ n s i t i v e fu-

g a p . Duncan W. Wilson. Michael Brunner, Nancy Arango, sion protein involved in vesicular transport. Mitsuo Ta-

and tJames E. Rothman

Protein kinase C-mediated phosphorylation of troponin I and C-protein in isolated myocardial cells is associated with inhibition of myofibrillar actomyosin MgATPase. Richard C. Ven.ema and J. F. Kuo

Cell biological studies with monoclonal and polyelonal antibodies against human easein kinase I1 subunit f3 demonstrate participation of the kinase in mitogenic signaling. Peter Lorenz, Ruiner Pepperkok, Wilhelm Ansorge, and Walter Pyerin

Tumor necrosis factor (TNF) up-regulates the expres- sion of p75 but not p55 TNF receptors, and both recep- tors mediate, independently of each other, up-regula- tion of transforming growth factor a and epidermal growth factor receptor mRNA. Holger Kaltho//, Christian Roeder, Manfred B r o c ~ h a ~ s , Heinz-Gunter Thiele, and Wol// Schrniegel

The specific subcellular localization of two isoforms of cytochrome bn suggests novel targeting pathways. A n -

Borgese tonello D’Arrigo* Ernesto Man.era, Renato Longhi, and Nica

Molecular characterization of the family of the N-

Koki Moriyoshi, Hidemitsu Sugihara, Kazuhiro Sakurada, methyl-D-aspartate receptor subunits. Takahiro lshii,

Hiroshi Kadotani, Mineto Yokoi, Chihiro Akazawa, E-yuichi Shigemoto, Noboru Mizuno, Masayuki Masu, and Shigetada Nakanishi

Biosynthesis of the vasoactive lipid monobutyrin. Cen- tral role of diacylglycerol. William 0. ilkis is on and Bruce M. Spiegelman

Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial

Ken-iehi Naruo, C h ~ a k o Seko, Ken-ichi K u r o s h i ~ a , Etsuya cell growth. Purification and biological properties.

Matsutani, Reiko Sasada, Tatsuya Kondo, and Tsutomu Kurokawa

Pancreatic-type phospholipase A2 stimulates prosta- glandin synthesis in mouse osteoblastic eells (MC3T3- E l ) via a specific binding site. M ~ a h ~ r o Tohkin. Junji Kishino, J u n Ishizaki, and Hitoshi Arita

vii

viii

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3016

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High level thrombospondin 1 expression in two NIH

pendent growth. Valerie P. Castle, Xianglan Ou, Karen 3T3 cloned lines confers serum- and anchorage-inde-

O'Rourke, and Vishua M. Dixit

Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and ~ 1 8 5 ~ ~ ~ ~ . Evi- dence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of hu- man epithelial cells. Gibbes R. Johnson, Bhanu Kanmn, M o ~ m m e d Shoyab, and Kurt Strornberg

Differential transforming abilities of non-secreted and secreted forms of human fibroblast growth factor-1. Reza Forough, Xi Zhan, Martin MacPhee, Stanley Friedman, Kurt A. Engleka, T h o m ~ Sayers, Robert H. Wiltrout, and Thomas Maciag

Expression of biologically active recombinant keratin- ocyte growth factor. Structure/function analysis of amino-terminal truncation mutants. D i m Ron, Donald P. Bottaro, Paul W. Finch, David Morris, Jeffrey S. Rubin, and Stuart A. Aaronson

Expression of native and truncated forms of the human integrin ax subunit. Roger Briesewitz, Marc R. Epstein, and Eugene E. Marcantonio

Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-Ll adipo- cytes. Diane C. Fingar, Sharon F. Hausdorff, John Blenis, and Morris J . Birnbaum

mechanism which is dependent on F-actin. Vol. 267 Serum regulates Na+/H+ exchange in Caco-2 cells by a

Donowttz, and M a ~ s ~ l l H. Montrose (1992)956-962.Atastair J. M. Watson, Susan Leuine, Mark

hyde-3-phosphate dehydrogenase inhibits enzymatic Nitric oxide-induced S-nitrosylation of glyceralde-

activity and increases endogenous ADP-ribosylation. Vol. 267 (1992) 24929-24932. L u i s ~ o l l n a ~ Vedia, Brad McDonald, Bryan Reep, Bernhard Briine,, Mauricio Di Siluio, Timothy R. Billiar, and Eduardo G. Lapetzna

ENZYMOLOGY T4-phage deoxycytidylate deaminase is a metallopro-

Moore, Ruth E. Siluersmith, Gladys F. Maley, and Frank Maley tein containing two zinc atoms per subunit. John T.

binds a second molecule of thrombin. Jia Ye, Charles T. The chondroitin sulfate moiety of thrombomodulin

Esmon, and Arthur E. Johnson

Enhanced stimulation of myosin subfragment 1 ATPase

the yeast actin NHp terminus. R. Kirn~r ley Cook, D o u g h activity by addition of negatively charged residues to

Root, Carl Miller, Emil Reisler, and Peter A. Rubenstern

Alternative substrates for calf intestinal adenosine de- aminase. A pre-steady-state kinetic analysis. Dauid J. T. Porter and Thomas Spector

Biochemical analysis of human immunodeficiency vi- rus-1 reverse transcriptase containing a mutation at position lysine 263. J . Louise Martin, Jeanne E. Wilson, Eric S. Furfine, Samuel E. Hopkins, and Phzllzp A. Furrnan

bound protein carboxyl methyltransferase from rat Purification and characterization of a membrane-

kidney cortex. Dominique Boiuin, Denis Gingras, and Rich- ard Bbliueau

Enzymatic analysis of two HIV-1 reverse transcriptase mutants with mutations in carboxyl-terminal amino acid residues conserved among retroviral ribonucleases H. Silke Volkmann, Birgitta Maria Wohrl, Margaret Tisdale, and Karin M o e l l i ~

Purification and characterization of a protein tyrosine phosphatase containing SH2 domains. Zhizhuang Zhao, Patrice Bouchard, Curtis D. Diltz, Shi-Hsiang Shen, and Ed- mond H. Fischer

MEMBRANES AND BIOENERGETICS Structural and functional analysis of the human vaso- active intestinal peptide receptor glycosylation. Alter-

Jan Chocholo, Catherine Fabre, Catherme Bellan! Jose LUIS, ation of receptor function by wheat germ agglutini?

Syluain Bourgerie, Brigitte Abadie, Serge Champzon, Jacques Marualdi, and Assou El Battari

2324 Expression of rat liver reduced glutathione transport in Xenopus laevis oocytes. Jose Carlos Fernandez-Checa, Jian-R. Yi, Carmen Garcia-Ruiz, Zorica Knezic, Stanley M. Tahara, and Neil Kaplowitz

2712 Two isoforms of the EPs receptor with different car- boxyl-terminal domains. Identical ligand binding prop- erties and different coupling properties with Gi pro- teins. Yukihikn Sugimoto, Manabu Negishi, Yasunori Hay- ashi, Tsunehisa Namba, Akiko Honda, Akikn Watabe, Masakazu Hirata, S M Narumiya, and Atsushi Ichikuwa

2740 Alternative splicing of exons encoding the calmodulin- binding domains and C termini of plasma membrane CaZ+-ATPase isoforms 1,2,3, and 4. Timothy P. Keeton, Scott E. Burk, and Gary E. Shut1

2809 Identification of regions in the Ca2+-ATPase of sarco- plasmic reticulum that affect functional association with phospholamban. Toshzhiko Toyofuku, Kazzmzerz Kur- z yd~wsk i , M~hih iko Tada, and David H. M ~ L e n ~ n

2969 Purification of a 90-kDa protein (band VII) from car- diac sarcoplasmic reticulum. Identification as calnexin

sites. Steuen E. Cala, Corinne ~lbright, Jeffry S. Kelley> and and localization of casein kinase I1 phosphorylation

Larry R. Jones

NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS

-2273

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In vivo generation of an adenylylcyclsse isoform with a half-molecule motif. Shuichi Katsushiku, Jun-ichi Ka- wabe, Charles J , Homcy, and Yoshihira Ishikawa

Direct interaction between the transcriptional activa- tion domain of human p53 and the TATA box-binding protein. Ray Truant, Hua Xiao, C, James Ingles, and Jack Greenblatt

Adenovirus-mediated augmentation of cell transfection with unmodified plasmid vectors. Kunihiko Y o s h i m u ~ Melissa A. Rosenfeld, Prem Seth, and Ronald G. Crystal

Guanosine tetraphosphate inhibits protein synthesis in vivo. A possible protective mechanism for starvation stress in Escherichia coli. Amy L. Suitit, Michael Cashel, and J ~ i t h W. Zyskznd

Import and assembly of the &subunit of chloroplast coupling factor 1 (CF1) into isolated intact chloroplasts. Geoffrey G. Chen and Andre T. Jagendorf

Novel activity of a yeast ligase deletion polypeptide. Evidence for GTP-dependent tRNA splicing. Shawn K. Westaway, Heather G. Belford, Barbara L. Apostol, John Abel- son, and Chris L. Greer

Multiple nucleotide cofactor use by yeast ligase in tRNA splicing. Evidence for independent ATP- and GTP- binding sites. Heather G. Belford, Shawn K. Westaway, John Abelson, and Chris L. Greer

The activity-cont~lling p h ~ p ~ o ~ l a t i o n site is not the same in the four acidic ribosomal proteins from Sac-

and Juan P. G. Ballesta charomyces cerevisiae. Tatjana Naranda, Miguel Remocha,

Deletion mutagenesis of high molecular weight kini- nogen light chain. Identification of two anionic surface binding subdomains. Satya P. Kunapuli, Raul A. D e h Cadena, and Robert W. Colman

of the mouse pro-aZ(1) collagen enhancer. Robert J . Po- Contribution of specific cis-acting elements to activity

gulis and Suend 0. Freytag Purification and structural characterization of tran- scriptional regulator Leu3 of yeast. Ji- Ying Sze and Gun- ter B. K o h l ~ w

Analysis of transcriptional stimulation by recombinant Oct proteins in a cell-free system. Arnd Annweiler, Stefan Zwilling, Robert A. Hipskind, and Thomas Wirth

guns. Structural organization and inducible, cell-spe- The novel me~llothionein genes of C a e ~ o ~ h a ~ ~ ~ i s ele-

cific expression. Jonathan H. Freedman, Lee W. She , Den- nis Dixon, Andrew Fire, and Charles S. Rubin

Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione perox- idase, GSHPx-GI. Fong-Fong Chu, James H. Doroshow, and R. Steuen Esworthy

- Indicates a Communication

ix

2533

2602

2623

2632

2649

2667

2684

2693

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2755

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2793

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2893

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2909

A second form (@ isoform) of nucleoside diphosphate

plementary and genomic DNA and expression. ~ o b u k o kinase from rat. Isolation and characterization of com-

Shimada, Naoshi Ishihama, Yoko Munakata, Tosifusa Toda, Kazutada Watanabe, and Narimichi Kimura

heart is regulated in part by an E-box-dependent mech- Expression of the a-myosin heavy chain gene in the

anism. Jeffery D. Molkentin, Rebecca S. Brogan, Shawn M. Jobe, and Bruce E. Markham

In uiuo DNA-protein interactions at the divergent mer- cury resistance (mer) promoters. I. Metal lore~latory protein MerR mutants. VaErie Livrelli, Ike Whan Lee, and Anne 0. Summers

In vivo DNA-protein interactions at the divergent mer- cury resistance (mer) promoters. 11. Repressor/activa- tor (MerR)-RNA polymerase interaction with merOP

Paul A. Totis, and Anne 0. Summers mutants. Ike Whan Lee, Valerie Liurelli, Soon-Jung Park,

Gene-specific DNA repair of interstrand cross-links induced by chemotherapeutic agents can be preferen- tial. Florence Larminat, W e ~ i n g Zhen, and V~lhelm A. Bohr

two cases of type IV osteogenesis imperfecta (01). Ad- Serine for glycine substitutions in type I collagen in

ditional evidence for a regional model of 01 pathophys-

J . Chen, and Bonnie M. Orrison iology. Joan C. Marini, Mary Beth Lewis, Bin Wang, Kathleen

Reverse transcriptases from bacterial retrons require specific secondary structures at the 5’-end of the tem- plate for the EDNA priming reaction. Tadashi Shimamoto, Mei- Yin Hsu, Sumiko Inouye, and M ~ a y o r i Innuye

ras protein activity is essential for T-cell antigen recep- tor signal transduction. Cosima T. Baldari, Adriana Heguy, and John L. Telford

Transformation of the signal peptide/membrane anchor domain of a type I1 transmembrane protein into a cleav- able signal peptide. Patrice Roy, Christine Chatellard, Guy Lemay, Philippe Crine, and Guy Boileau

Fidelity of 629 DNA polymerase. Comparison between

Jose A. Esteban, Margarita Salas, and Luis Blanc0 protein-primed initiation and DNA polymerization.

AP-1 antagonizes thyroid hormone receptor action on

Hans J . Steinfelder, Michelle Nations, and Sally Radouick the thyrotropin 8-subunit gene. Fredric E. Wondisford,

The application of homology search to the identification The primary structure of rat ribosomal protein L23a.

of genes for mammalian and yeast ribosomal proteins and a correlation of rat and yeast ribosomal proteins. Katsuyuki Suzuki and Ira G. Wool

Recruitment of vaccinia virus RNA polymerase to an early gene promoter by the viral early transcription factor. Jing Li and Steuen S. Broyles

Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. C h i ~ - S ~ w u n Lin, Taesun Park, Zong Ping Chen, and John Leauitt

Characterization of the human L-plastin gene promoter in normal and neoplastic cells. Ching-Shwun Lin, Zong Ping Chen, Taesun Park, Karabi Ghosh, and John Leauitt

Exogenous, hut not endogenous, glucocorticoid recep- tor induces glutamine synthetase gene expression in early stage embryonic retina. Haiying Zhang and Anthony P. Young

Coupling muscle electrical activity to gene expression via a CAMP-dependent second messenger system. Ken- neth G. Chuhine, Edgardo Baracchini, and Daniel Goldman

A novel short consensus repeat-containing molecule is related to human complement factor H. Christine Skerka,

F. Zipfel Sabine Kiihn, Kathrin Giinther, Klaus Lingelbach, and Peter

A specific CCAAT-binding protein, CBP/tk, may he involved in the regulation of thymidine kinase gene expression in human IMR-SO diploid fibroblasts during senescence. Jong Hwei Pang and Kuung Y u Chen

2917

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2946

2976

2997

‘2296

2319

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2348

2380

2393

2403

2416

2425

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2535

Characterization of the nuclear and cytoplasmic com- ponents of the lymphoid-spec~fic nuclear factor of ac- tivated T cells (NF-AT) complex. Jeffrey P. Northrop, Katharine S. Ullman, and GemM R. Crabtree

Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the Pl-rP2-r TP2 locus. James E. Nelson and Stephen A. Krawetz

ertiea and binding to polynucleotides. Elmar Wahle, Ariel Mammalian poly(A)-binding protein 11. Physical prop-

Lust&, Paul Jeno, and Patrik Maurer

Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-gly- coprotein antagonists. Cynthia E. Herzog, Maria Tsokos, Susan E. Bates, and Antonio T. Fojo

Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2- 23.1. Edmond Crouch, Kevin Rust, Rosalie Veile, Helen Donis-Keller, and Leonard Grosso

Inhibition by barbiturates of the binding of Bm3R1 repressor to its operator site on the barbiturate-induc- ible cytochrome P 4 5 0 ~ ~ . 3 gene of Bacillus megaterium. Gwo-Chyuun Shaw and Armand J . Fulco

PROTEIN CHEMISTRY AND STRUCTURE An iron-sulfur center and a free radical in the active

Etienne Mulliez, Marc Fontecave, Jacques GaiUard, and Peter anaerobic ribonucleotide reductase of Escherichia coli.

Reichurd

Molecular basis for the species selectivity of the sub- stance P antagonist CP-96,345. Bruce S. Sachis, R. Mi- chael Snder, John A. Lowe III, and James E. Krause

Molecular cloning and sequence of a novel ommo-

d u m sexta. Gloria M. Yepiz-Plnscencia, Chnumei Ho, Ralph chrome-binding protein cDNA from an insect, Man-

R. Martel, and John H. Law

N-Myristylation of the catalytic subunit of CAMP-de- pendent protein kinase conveys structural stability. Wes Yonemoto, Maria L. McGlone, and Susan S. Taylor

Actin-binding peptides obtained from the C-terminal 24-kDa fragment of porcine aorta smooth muscle my- osin subfragment-1 heavy chain. Tsuyoshi Katoh and Fumi Morita

The mechanism of aluminum-independent G-protein activation by fluoride and magnesium. 31P NMR spec- troscopy and fluorescence kinetic studies. Bruno An- tonny, Muppalla Sukumar, Joelle Bigay, Mare Chabre, and Tsutomu Higashijima

Quantitative characterization of the structure of rho- dopsin in disc membrane by means of Fourier transform infrared spectroscopy. David Garcia-Quintana, Pere Gar- riga. and Joan Manyosa

human transthyretip and the amyloidogenic Val-30 + The x-ray crystal structure refinements of normal

Met variant to 1.7-A resolution. JeanA. Hamilton, Larry K. Steinrauf, Bradford C. Braden, Juris Liepnieks, Merrill D. Benson, Costa Holmgren, Ola Sandgren, and Lars Steen

X-ray crystal structure of the Ala-109 + Thr variant of human transthyretin which produces euthyroid hy- perthyroxinemia. Larry K. Steinrauf, Jean A. Hamilton, Bmdford C. Braden, Jill R. Murrell, and Merrill D. Benson

Initial interaction between fibrin and tissue plasmino- gen activator @-PA). The Gly-Pro-Arg-Pro binding site on fibrin(ogen) is important for t-PA activity. Elzbieta Kaczmarek, Myoung H. Lee, and Jan McDonagh

unfolding of rhodanese. Paul M. Horowitz and Michael Interactive intermediates are formed during the urea

Butler

tations regarding conserved histidine residues. Ying- Yi Iron content of human 5-lipoxygenase, effects of mu-

Zhung, Birger Lind, Olof Rlidmark, and Bengt Samuelsson

* Indicates a Communication

X

2616 Interaction of reconstituted high density lipoprotein discs containing human apolipoprotein A-I (ApoA-I) variants with murine adipocytes and macrophages. Evidence for reduced cholesterol efflux promotion by ApoA-I(Pro'" -+ Arg). Arnold uon Eckardstein, Graciela Castro, Iwona Wybranska, Nathalie Theret, Philippe Ducha- teau, Nicolas Duuerger, Jean-Charles Fruchart, Gerard Ail- haud, and Gerd Assmann

2727 Purification and crystallization of 2,3-dihydroxybi- phenyl 1,2-dioxygenase. Lindsay D. Eltis, Birgit Hofmann, Hans-Jiirgen Hecht, Heinrich Lunsdorf, and Kenneth N. Timmls

2767 Interactions of phage P22 tailspike protein with GroE

Brunschier, Martina Danner, and Robert Seckler molecular chaperones during refolding in vitro. Rainer

2821 Disulfide bond requirements for assembly of the plate- let glycoprotein Ib-binding domain of von Willebrand

Zaverio M. Ruggeri, and Jerry Ware factor. Hiroyuki Azuma, Tomohiro Hayashi, Judith A. Dent,

2872 Binding of protein S to Factor Va associated with in- hibition of prothrombinase that is independent of acti-

Jan Rasing, and John H. Griffin vated protein C. Mary J . Heeb, Rolf M. Mesters, Guido Tans,

2878 The conserved H1 domain of the type I1 keratin 1 chain plays an essential role in the alignment of nearest neighbor molecules in mouse and human keratin 1/ keratin 10 intermediate filaments at the two- to four-

A. D. Parry molecule level of structure. Peter M. Steinert and David

2888 Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identi- fies critical residues for its cofactor activity. Mariko Nagashima, Erik Lundh, Jill C. Leonard, John Morser, and John F. Parkinson

2953 Metabolism-based transformation of myoglobin to an oxidase by BrCC13 and molecular modeling of the oxi- dase form. Yoichi Osawa, John F. Darbyshire, Peter J . Stein- bach, and Bernard R. Brooks

3009 Neutrophil activation by nascent FimH subunits of type 1 fimbriae purified from the periplasm of Escherichia coli. Rupinder Tewari, Jennifer I . MacGregor, Teruo Ikeda, J . Russell Little, Scott J . Hultgren, and Soman N . Abraham

3016 Isolation, expression, and mutation of a rabbit skeletal muscle cDNA clone for Troponin 1. The role of the NH, terminus of fast skeletal muscle troponin I in its biolog- ical activity. Vol. 267 (1992) 25407-25413. Zelin Sheng, Bo-Sheng Pan, Todd E. Miller, and James D. Potter

Aaronson, Stuart A., 2984

Ahelson, John, 2435, 2444 Ahadie, Brigitte, 2312

Abraham, Soman N., 3009 Adams, Robert R., 2292 Ailhaud, Gerard, 2616 Akazawa, Chihiro, 2836 Andrews, William H., 2292 Annweiler, Arnd, 2525 Ansorge, Wilhelm, 2733 Antonny, Bruno, 2393 Apostol, Barbara L., 2435 Arango, Nancy, 2662 Arita, Hitoshi, 2865 Asahi, Momoyo, 2277 Assmann, Gerd, 2616 Audigier, Yves, 2368 Aukhil, Ikramuddin, 2542 Azuma, Hiroyuki, 2821 Baldari, Cosima T., 2693 Ballesta, Juan P. G., 2451 Baracchini, Edgardo, 2893 Bates, Susan E., 2946 Beaven, Michael A,, 2280 Belford, Heather G., 2435,

Beliveau, Richard, 2610 Bellan, Catherine, 2312 Benson, Merrill D., 2416,

Bigay, Joelle, 2393 Bhamidipati, Shastri P., 2431

Billiar, Timothy R., 3016 Birnhaum, Morris J., 3005 Blanco, Luis, 2719 Blenis, John, 3005 Blumherg, Peter M., 2280 Bohr, Vilhelm A,, 2649 Boileau, Guy, 2699 Boivin, Dominique, 2610 Borgese, Nica, 2802 Bottaro, Donald P., 2984 Bouchard, Patrice, 2816 Bourgerie, Sylvain, 2312 Braden, Bradford C., 2416,

Briesewitz, Roger, 2989 Brockhaus, Manfred, 2762 Brogan, Rebecca S., 2602

Broyles, Steven S., 2773 Brooks, Bernard R., 2953

Brune, Bernhard, 3016

2444

2425

2425

Brunner, Michael, 2662 Brunschier, Rainer, 2767 Burg, Debra L., 2304 Burk, Scott E., 2740 Butler, Michael, 2500 Cala, Steven E., 2969 Cashel, Michael, 2307 Castle, Valerie P., 2899 Castro, Graciela, 2616 Chahre, Marc, 2393 Chahine, Kenneth G., 2893

Chatani, Yuji, 2577 Champion, Serge, 2312

Chatellard, Christine, 2699 Chen, Geoffrey G., 2363 Chen, Kathleen J., 2667 Chen, Kuang Yu, 2909 Chen, Zong Ping, 2781, 2793 Chochola, Jan, 2312 Chu, Fong-Fong, 2571 Colman, Robert W., 2486 Cook, R. Kimherley, 2410 Crabtree, Gerald R., 2917 Crawley, Suzanne C., 2468 Crine, Philippe, 2699 Crouch, Edmond, 2976 Crystal, Ronald G., 2300

Danner, Martina, 2767 Darbyshire, John F., 2953

DeLa Cadena, Raul A,, 2486 D'Arrigo, Antonello, 2802

Dell, Anne, 2353 Dent, Judith A,, 2821 Diehl, Anna Mae, 2595 Diltz, Curtis D., 2816 Di Silvio, Mauricio, 3016 Dixit, Vishva M., 2899 Dixon, Dennis, 2554 Donis-Keller, Helen, 2976 Donowitz, Mark, 3016 Doroshow, James H., 2571 Dower, Steven K., 2513 Duchateau, Philippe, 2616 Duverger, Nicolas, 2616

El Battari, Assou, 2312 Eltis, Lindsay D., 2727 Engleka, Kurt A,, 2960

Erickson, Harold P., 2542 Epstein, Marc R., 2989

Esmon, Charles T., 2373

AUTHOR INDEX

Estehan, Jose A,, 2719 Esworthy, R. Steven, 2571

Fabre, Catherine, 2312 Faria, Teresa N., 2655 Fernandez-Checa, Jose

Finch, Paul W., 2984 Fingar, Diane C., 3005 Fire, Andrew, 2554 Firestone, Gary L., 2329 Fischer, Edmond H., 2816 Fojo, Antonio T., 2946 Fontecave, Marc, 2296 Forough, Reza, 2960 Freedman, Jonathan H., 2554 Freytag, Svend O., 2493 Friedman, Stanley, 2960 Fruchart, Jean-Charles, 2616 Fulco, Armand J., 2997 Furfine, Eric S., 2565 Furman, Phillip A,, 2565 Gaillard, Jacques, 2296 Garcia-Quintana, David, 2403 Garcia-Ruiz, Carmen, 2324 Garriga, Pere, 2403 Geahlen, Robert L., 2304 Gershengorn, Marvin C.,

Ghosh, Karahi, 2793

Goldman, Daniel, 2893 Gingras, Denis, 2610

Goldsmith, Paul, 2368 Goodman, Laurie J., 2329 Greenhlatt, Jack, 2284 Greer, Chris L., 2435, 2444 Griffin, John H., 2872 Grosso, Leonard, 2976 Gunther, Kathrin, 2904

Hamilton, James A., 2431 Hamilton, Jean A,, 2416,

Harrison, Marietta L., 2304 Hattori, Akira, 2577 Hausdorff, Sharon F., 3005 Hayashi, Kyozo, 2577 Hayashi, Tomohiro, 2821 Hayashi, Yasunori, 2712

Heeb, Mary J., 2872 Hecht, Hans-Jurgen, 2727

Heguy, Adriana, 2693

Carlos, 2324

2389

2425

Heinflink, Marcos, 2389

Higashijima, Tsutomu, 2393 Herzog, Cynthia E., 2946

Hindsgaul, Ole, 2468 Hipskind, Robert A,, 2525 Hirata, Masakazu, 2712 Ho, Chaumei, 2337 Hofmann, Birgit, 2727 Hollingsworth, Rawle I., 2828 Holmes, Richard, 2292 Holmgren, Gosta, 2416 Homcy, Charles J., 2273 Honda, Akiko, 2712 Hopkins, Samuel E., 2565 Horowitz, Paul M., 2500 Hsu, Mei-Yin, 2684 Hultgren, Scott J., 3009 Ichikawa, Atsushi, 2712 Ikeda, Teruo, 3009 Ingles, C. James, 2284 Inocencio, Noel M., 2590 Inoue, Sadako, 2353,2640 Inoue, Yasuo, 2353,2640 Inouye, Masayori, 2684 Inouye, Sumiko, 2684 Ishida, Nohuhiro, 2577 Ishii, Takahiro, 2836 Ishikawa, Naoshi, 2583 Ishikawa, Yoshihiro, 2273

Ito, Fumio, 2640 Ishizaki, Jun, 2865

Iwamatsu, Takashi, 2353 Jagendorf, Andre T., 2363 Jeno, Paul, 2937 Jobe, Shawn M., 2602 Johnson, Arthur E., 2373 Johnson, Gibbes R., 2924 Jolley, Duffy, 2292 Jones, Larry R., 2969 Joshi, Paritosh, 2542 Jouneaux, Catherine, 2368 Jung, Seunho, 2828 Kaczmarek, Elzhieta, 2474 Kadotani, Hiroshi, 2836 Kain, Steven R., 2329 Kalthoff, Holger, 2762 Kanie, Osamu, 2468

Kaplowitz, Neil, 2324 Kannan, Bhanu, 2924

Kato, Hisanori, 2655

Katoh, Tsuyoshi, 2380

Kawahe, Jun-ichi, 2273 Katsushika, Shuichi, 2273

Kazanietz, Marcelo G., 2280 Keeton, Timothy P., 2740

Khan, Shaheer H., 2468 Kelley, Jeffry S., 2969

Khoo, Kay-Hooi, 2353 Kimura, Narimichi, 2583 Kishino, Junji, 2865 Kitagawa, Hiroshi, 2277 Kitajima, Ken, 2353,2640 Kitazume, Shinobu, 2640 Knezic, Zorica, 2324 Kohlhaw, Gunter B., 2505 Kohno, Michiaki, 2577 Kondo, Tatsuya, 2857 Krause, James E., 2319 Krawetz, Stephen A., 2932 Kuhn, Sahine, 2904 Kunapuli, Satya P., 2486

Kurokawa, Tsutomu, 2857 Kuo, J. F., 2705

Kuroshima, Ken-ichi, 2857 Kurzydlowski, Kazimierz,

Lapetina, Eduardo G., 3016 Larminat, Florence, 2649 Law, John H., 2337 Leavitt, John, 2781, 2793 Lee, lke Whan, 2623,2632 Lee, Myoung H., 2474 Lemay, Guy, 2699 Leonard, Jill C., 2888 LeRoith, Derek, 2655 Levine, Michael A,, 2595 Levine, Susan, 3016

Li, Jing, 2773 Lewis, Mary Beth, 2667

Liepnieks, Juris, 2416 Lin, Ching-Shwun, 2781,

Lind, Birger, 2535 Lingelhach, Klaus, 2904 Lipsky, Peter E., 2458 Little, J. Russell, 3009 Livrelli, Valerie, 2623, 2632 Lohman, Timothy M., 2269 Longhi, Renato, 2802

Lotersztajn, Sophie, 2368 Lorenz, Peter, 2733

Lowe, John A,, 111, 2319

2809

2793