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7/27/2019 VitiligoLK KJ
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VITILIGO
April 26th, 1999
Chemistry 412Rick Helgemo
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What is vitiligo?
Autoimmune disorder
Genetic link
Affects 1-2% of population
Difficult to cure
Harmful effects
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http://localhost/var/www/apps/conversion/tmp/scratch_2//SGS1/helgemrj$/Documents/moocow.au7/27/2019 VitiligoLK KJ
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Untreated Vitiligo
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Autoimmune disorder
Melanocytes destroyed
*Melanocyte-specific differentiation
antigens
*Tyrosinase, Dopachrome isomerase
(TRP-2), gp100, MART-1
Immunoglobulin G recognizes TRP-2, causing
immune response
Possible link to curing melanoma?
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Genetic Links
Two types-Segmental and nonsegmental
Polygenic nature, multifactorial inheritance
Autosomal and not linked to race or sex
Linked to other autoimmune diseases
Weakly heritable
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Curing Vitiligo Effects
Long and difficult process, rarely 100% effective on individual
Always involves sunlight or ultraviolet light
Physical and chemical methodsCosmetics
Depigmentation
Psychological counseling
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Chemical Treatment Options for
VitiligoCorticoids
Psoralens (PUVA)
Phenylalanine
P-aminobenzoic acid (PABA)
Cantharidin, a blister beetle secretion
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Physical Treatment Options for
VitiligoTattooing (micropigmentation)
Autologous skin grafts
Skin grafting using blisters
Autologous melanocyte transplantation
Combination of Sun and Sunscreen
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References:Anti-tyrosinase-related protein-2 immune response in vitiligo patients;
Okamoto T, Irie RF, Fujii S, etal.; The Journal of Investigative Dermatology; Dec 1998;
111:1034-1039.
Autoantibodies to Tyrosinase-related protein-1 detected in the sera ; Kemp EH, Waterman EA,
Gawkrodger DJ, et al.;British Journal of Dermatology 1998; 139:798-805.
A systematic review of autologous transplantation methods in vitiligo; Njoo MD,Westerhof W, Bos JD,
Bossuyt PMM; Archives of Dermatology, Dec 1998 134:1543-1549.
The genetics of vitiligo in Korean patients; Kim SM, Chung HS, Hann SK;International Journal of
Dermatology 1998; 38:908-910.
On the association between vitiligo and malignant melanoma; Lindelof B, Hedblad MA, Sigurgeirsson
B; Acta Dermatologica Venereologica; 1998 78:483-484.
Tyrosinase as an autoantigen in patients with vitiligo; Baharav E, Merimsky O, Shoenfeld Y, et al.;
Clinical Experimental Immunology; 1996 105:84-88.
Nonsurgical repigmentation therapies in vitiligo; Njoo MD,Westerhof W, Bos JD, Bossuyt PMM;
Archives of Dermatology; Dec 1998 134:1532-1540.
Spontaneous repigmentation of vitiligo patches distant from the autologous skin; Malakar S, Dhar S;
Dermatology; 1998 197:274.
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More References
Treatment of vitiligo with oral and topical phenylalanine: 6 years of experience; Camacho F,
Mazuecos J; Archives of Dermatology; Feb 1999 135:216-217.
UV-dependent melanocyte plasticity-The structure-function relationship; Iyengar B; Indian Journal of
Pathological Microbiology; 1996 39(2):105-109.
Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts;Schwartzmann-Solon AM, Visconti MA, Castrucci AML; Brazilian Journal of Medical and
Biological Research; 1998 31:1557-1564.
Repigmentation of vitiligo lesion after beetle dermatitis; Parsad D, Saini R, Nagpal R; Dermatology;
1998 197:398.