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7/30/2019 VITAMINS MALE AND FEMALE INFERTILITY
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THE IMPORTANCE OF VITAMINS IN MALE AND FEMALE INFERTILITY
DR. SULEIMAN DABITHEAD OF ART AND GENETIC
DEPARTMENT AL KHALIDI MEDICAL CENTER
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Questions?
What vitamins are good for women to
become more fertile?What kinds of vitamins can men taketo increase fertility?
What can I take to increase spermmobility?
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Oxidative Stress and Infertility
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Counteracting All Factors of Oxidative Stress
Endogenous
MetabolismInflammation
InfectionsDiseases
Respiratory burstHypoxia-
reperfusionStress
Exogenous
SmokingPollutionRadiation
DrugsFood additives
InsecticidesPesticides
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Oxidative Stress Plays An Essential Role In Acceleration
Of ManyChronic Diseases
Atherosclerosis Alzheimer Liver disease
Chronic eye diseaseMale & female
infertility Threatened abortion
Immune system
disorders Diabetic nephropathy Diabetic neuropathy
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Counteracting All Factors of Oxidative Stress
Free Radicals(Oxidative Factors)
A molecule left with unpairedelectron circulating to get paired
from different cells known as a freeradical
Antioxidant(Donor Factor Protective
Factor)
A molecule which prevents orslows down oxidation by donating
electron to free radical while
staying stable
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*Ashok Agarwa l , PhD, HCLD and S a j a l G u p t a ,MD
Oxidative StressAffects Multiple Physiological Processes
Embryo Development And Pregnancy*Oocyte Maturation To Fertilization*
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Plasma membranes containlarge quantities of
polyunsaturated fatty acids
Cytoplasm contains lowconcentrations of thescavenging enzymes
Spermatozoa Are The Most Susceptible To ROS**
Due To
Oxidative StressIs A Common Pathology In Approximately
50%Of Infertile Men*
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Damage to sperms DNA resultsin infertility
(Teratozoospermia)
Damage to sperm membrane
decrease sperms motility(Athenozoospermia)
Higher Levels Of ROS & Lower Levels OfProtective Antioxidants Within Their Semen
Leading To
Rather Than All Men,Those Suffering From
InfertilityHas Significantly*
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Free RadicalsWhen DNA is attacked, it can be alsoaltered by free radicals.Ovum and sperm cells can be affectedby free radical damage so are thereproductive organ and glands thatproduce reproductive hormones
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DNA Fragmentation
Damaged DNA can causemiscarriages or birth defects anddevelopmental problems for the futurechild.
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Antioxidants for male
subfertility (Review)Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ
This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration andpublished in The Cochrane Library, 2011, Issue 11
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[Intervention Review]Antioxidants for male
subfertility A B S T R A C TBackgroundBetween 30% to 80% of male subfertility cases are considered to
be due to the damaging effects of oxidative stress on sperm. Oralsupplementation with antioxidants may improve sperm quality byreducing oxidative stress.
ObjectivesThis Cochrane review aimed to evaluate the effect of oral
supplementation with antioxidants for male partners of couples
undergoing assisted reproduction techniques (ART).Search strategyThis Review searched the Cochrane Menstrual Disorders and
Subfertility Group Register, CENTRAL (The Cochrane Library),MEDLINE,
EMBASE, CINAHL, Psyc INFO and AMED databases (from their inception until February 2010), trial registers, sources of un ublished literature, reference lists and the asked ex erts in
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[Intervention Review]Antioxidants for male
subfertility Selection criteriaThis Review included 34 randomisedcontrolled trials with 2876 couples intotal comparing any type or dose of antioxidant supplement (single or combined) taken by the male partner of a couple seeking fertility assistancewith placebo, no treatment or another antioxidant.
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[Intervention Review]Antioxidants for male
subfertility Main results
Live birth : Men taking oral antioxidants had an associatedstatistically significant increase in live birth rate (pooled oddsratio (OR) 4.85, 95% CI 1.92 to 12.24; P = 0.0008 , I2 = 0%)when compared with the men taking the control.Pregnancy rate : there were 96 pregnancies in 15 trials including 964 couples. Antioxidant use was associated with a statistically significant increased pregnancy rate comparedto control (pooled OR 4.18, 95% CI 2.65 to 6.59; P