V I T A L I T Y

vitality™

Dramatically improves medication adherence, through wireless packaging, reminders, reports, and rewards.

vitality™

GlowCaps are recognized as important and innovative

This is what non-adherence looks like... Each row is person, each column is a day. Red indicates a missed dose.

Control groups=70%

This is what adherence looks like with GlowCaps

Over 95%

Existing studies have quantified the cost-savings of high medication adherence:

cost effective

ConditionLow adherence

care costsHigh adherence

care costssavings per

year

Diabetes $8,867 $4,570 $4,297 48%

High

Cholesterol$6,888 $3,924 $2,964 43%

High Blood

pressure$10,916 $6,752 $4,164 38%

Multiple

ailments$16,498 $8,886 $7,612 46%

Medical Care, 2005, vol. 43, no6, pp. 521-530 SOKOL Michael C. ; MCGUIGAN Kimberly A. ; VERBRUGGE Robert R. ; EPSTEIN Robert S.

Source: IMS Health

V I T A L I T Y

Chronic disease a!ects 25% of adults in the US, yet most take medication 50% of the time.

Simple to use

• Plug it in to connect

• No PC, phone, or Internet required

• One-button refill

1) Pharmacist deliver your medication in a GlowCap and explains how it works.

“The smart pill cap will help you to remember with light, sound, and if you want, a reminder call.”

2) At home, you plug in the reminder light.

3) Every day, the GlowCap and reminder light flash for an hour, then play a ring tone every few minutes until you open the GlowCap.

4) If you forget, Vitality can call to remind you.

5) Weekly emails show which days you did, or didn’t, take a medication.

6) Every month you receive a printed progress report in the mail.

7) Cap embeds a “Push to refill” button

Patent pending

=

V I T A L I T Y confidential

Vitality addresses each of the root causes of non-adherence

Forgetfulness Reminders escalate from subtle to insistent

Poor Education Personalized interactive media educates

No Social Support Progress is shared with a buddy

No Accountability Reports inform your doctor, via e-health record

Refill Inconvenience Refill requests automatically flow into pharmacy

Low Motivation Rewards motivate via loss aversion

Adherence Issue Vitality’s Approach

V I T A L I T Y

Vitality addresses each of the root causes of non-adherence

2) Program Support• Dedicated IT administrative portal• eMail and printed reports customization• Customer surveys (periodic)

3) Access to Real-Time Reports• Sort by condition, medication, member number, MPR, mean refill frequency, demographics, etc.• Consolidated physician reporting across patients

• Wireless GlowCaps and Reminder light (cellular gateway)• Missed-dose calls• Weekly email summaries• Monthly printed reports mailed to patients’ homes

1) GlowCaps and Services

Working with Vitality: What you receive

An unprecedented, secure data feed updates daily.

Vitality radarpharmaciesCVS 145Walgreens 93Walmart 22Express Scripts 3RiteAid 1

physiciansRose 1Smith 3Goldblatt, 8

conditionsHypertension 65Asthma 3Diabetes 22

medicationsDiovan 34Liptor 13Gleevec 5

adherence>80%60-80%40-60%<40%

V I T A L I T Y

Vitality™

Contact:

David Rose

drose@Vitality.net

617 517 6037

One Broadway, 14th floor

Cambridge, MA 02142

APPENDIX Patents pending

Medicine Bottle Cap with Embedded Curved Display

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Medicine Bottle Cap with Embedded Trigger for Refilling

Network Operations Center (NOC)

Medication Container

Cap

Connector

PatientDatabase

S106112

104

108

110

102

Local End(e.g., Patient’s home)

Back end ExternalEntities

Rules / Escalation

engine

Messaging Platform

Doctor(s)

Pharmacies

External messaging

Messaging device(s)

System manager

116

118

122

114

LearningAlgorithm

120

Feedback Indicator

Container

PeripheralSensors

Other(s)

115

107

I

111

2694-0002

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Medication Compliance System, Method and Devices with

Configureable and Adaptable Escalation Engine

Our patented learning engine adapts to the motivational

profile of each GlowCap owner to tailor services.

1. Enroll 2. Ingest 3. Survey 4. Observe Intervention plans

Vitality Programs

Profiles dB

Patients via pharmacy partner

Demographic features.

Attitudinal features (ongoing)

Patterns of behavior Programs to motivate behavioral change. Each intervention activates a specific personalty type, and has an associated $ and duration.

Financial incentive

Social incentives

Strong social norming message

Modality preference: SMS, paper

Doctor information sharing

Each individual is prescribed a tailored plan.

People features and usage history is stored

Bayesian classifier statistically matches interventions to people, minimizing price while optimizing behavioral outcomes.

APPENDIX

Market details

Vitality targets chronic asymptomatic conditions worth billions in drug sales

Pharma

Vitality targets chronic asymptomatic conditions worth billions in drug sales

Pharma

The market opportunity for a 25% lift in adherence amounts to over $24B.

Pharma

The pharma market opportunity in heart disease alone is over $24B.

Pharma