http://www.bleepingcomputer.com/forums/t/457771/vista-home-premium-32-bit-becomes-almost-unresponsive-when-started-normally/Vista Home Premium (32-bit) becomes almost unresponsive when started normallyHello, try rebooting into safe mode with Networking and run these.Reboot into Safe Mode with NetworkingHow to enter safe mode(XP/Vista)Using the F8 MethodRestart your computer.When the machine first starts again it will generally list some equipment that is installed in your machine, amount of memory, hard drives installed etc. At this point you should gently tap the F8 key repeatedly until you are presented with a Windows XP Advanced Options menu.Select the option for Safe Mode with Networking using the arrow keys.Then press enter on your keyboard to boot into Safe Mode.>>>> Download this file and doubleclick on it to run it. Allow the information to be merged with the registry.2.0Download and Run RKill Please download RKill by Grinler from one of the 4 links below and save it to your desktop. Before we begin, you should disable your anti-malware softwares you have installed so they do not interfere RKill running as some anti-malware softwares detect RKill as malicious. Please refer to this page if you are not sure how. Double-click on Rkill on your desktop to run it. (If you are using Windows Vista, please right-click on it and select Run As Administrator) A black screen will appear and then disappear. Please do not worry, that is normal. This means that the tool has been successfully executed. If nothing happens or if the tool does not run, please let me know in your next replyDo not reboot your computer after running rkill as the malware programs will start again. Or if rebooting is required run it again.If you continue having problems running rkill.com, you can download iExplore.exe or eXplorer.exe, which are renamed copies of rkill.com, and try them instead.3.Please download TDSSKiller.zip and and extract it. Run TDSSKiller.exe. Click Start scan. When it is finished the utility outputs a list of detected objects with description. The utility automatically selects an action (Cure or Delete) for malicious objects. The utility prompts the user to select an action to apply to suspicious objects (Skip, by default). Let the options as it is and click Continue Let reboot if needed and tell me if the tool needed a reboot. Click on Report and post the contents of the text file that will open. Note: By default, the utility outputs the log into system disk (it is usually the disk with installed operating system, C:\) root folder. The Log has a name like: TDSSKiller.Version_Date_Time_log.txt.If TDSSKiller does not run, try renaming it. To do this, right-click on TDSSKiller.exe, select Rename and give it a random name with the .com file extension (i.e. 123abc.com). If you do not see the file extension, please refer to these[/color] instructions. In some cases it may be necessary to redownload TDSSKiller and randomly rename it before downloading and saving to the computer.4.Next run Superantisypware (SAS):Download and scan with SUPERAntiSpyware Free for Home Users Double-click SUPERAntiSpyware.exe and use the default settings for installation. An icon will be created on your desktop. Double-click that icon to launch the program. If asked to update the program definitions, click "Yes". If not, update the definitions before scanning by selecting "Check for Updates". (If you encounter any problems while downloading the updates, manually download them from here. Double-click on the hyperlink for Download Installer and save SASDEFINITIONS.EXE to your desktop. Then double-click on SASDEFINITIONS.EXE to install the definitions.) In the Main Menu, click the Preferences... button. Click the Scanning Control tab. Under Scanner Options make sure the following are checked (leave all others unchecked): Close browsers before scanning. Scan for tracking cookies. Terminate memory threats before quarantining. Click the "Close" button to leave the control center screen. Back on the main screen, under "Scan for Harmful Software" click Scan your computer. On the left, make sure you check C:\Fixed Drive. On the right, under "Complete Scan", choose Perform Complete Scan. Click "Next" to start the scan. Please be patient while it scans your computer. After the scan is complete, a Scan Summary box will appear with potentially harmful items that were detected. Click "OK". Make sure everything has a checkmark next to it and click "Next". A notification will appear that "Quarantine and Removal is Complete". Click "OK" and then click the "Finish" button to return to the main menu. If asked if you want to reboot, click "Yes". To retrieve the removal information after reboot, launch SUPERAntispyware again. Click Preferences, then click the Statistics/Logs tab. Under Scanner Logs, double-click SUPERAntiSpyware Scan Log. If there are several logs, click the current dated log and press View log. A text file will open in your default text editor. Please copy and paste the Scan Log results in your next reply. Click Close to exit the program.If you have a problem downloading, installing or getting SAS to run, try downloading and using the SUPERAntiSpyware Portable Scanner instead. Save the randomly named file (i.e. SAS_1710895.COM) to a usb drive or CD and transfer to the infected computer. Then double-click on it to launch and scan. The file is randomly named to help keep malware from blocking the scanner.5.0Now run MBAM (MalwareBytes):Please download Malwarebytes Anti-Malware Posted Image and save it to your desktop. Important!! When you save the mbam-setup file, rename it to something random (such as 123abc.exe) before beginning the download.Malwarebytes may "make changes to your registry" as part of its disinfection routine. If using other security programs that detect registry changes (ie Spybot's Teatimer), they may interfere or alert you. Temporarily disable such programs or permit them to allow the changes. Make sure you are connected to the Internet and double-click on the renamed file to install the application. When the installation begins, follow the prompts and do not make any changes to default settings. Malwarebytes will automatically start and you will be asked to update the program before performing a scan. If an update is found, the program will automatically update itself. Press the OK button and continue. If you cannot update Malwarebytes or use the Internet to download any files to the infected computer, manually update the database by following the instructions in FAQ Section A: 4. Issues. Under the Scanner tab, make sure the "Perform Quick Scan" option is selected. Click on the Scan button. When finished, a message box will say "The scan completed successfully. Click 'Show Results' to display all objects found". Click OK to close the message box, then click the Show Results button to see a list of any malware that was found. Make sure that everything is checked and then click Remove Selected.Some types of malware will target Malwarebytes and other security tools to keep them from running properly. If that's the case, go to Start > All Programs > Malwarebytes Anti-Malware folder > Tools > click on [color=blue]Malwarebytes Chameleon and follow the onscreen instructions. The Chameleon folder can be accessed by opening the program folder for Malwarebytes Anti-Malware (normally C:\Program Files\Malwarebytes' Anti-Malware or C:\Program Files (x86)\Malwarebytes' Anti-Malware).Please ask any needed questions,post logs and Let us know how the PC is running now.