Vision To be an internationally leading center that develops, uses and provides access to advanced technologies for molecular biosciences with focus on

Vision

To be an internationally leading center that develops, uses and provides access to advanced technologies for molecular biosciences with focus on health and environment.

Organization

Board

• Professor Göran Sandberg, Government appointed Chair, Executive Director, Knut and Alice Wallenberg Foundation

• Margareta Olsson Birgersson, Government appointed Industry representative, Medical Director, Roche Sweden

• Professor Sophia Hober, Dean of Faculty, KTH Royal Institute of Technology• Stellan Sandler, Pro Vice-Chancellor, Uppsala University• Professor Hans Adolfsson, Pro Vice-Chancellor, Stockholm University• Professor Hans-Gustaf Ljunggren, Dean of Research, Karolinska Institutet• Professor Maria Anvret, Senior Advisor, University of Gothenburg• Professor Gunilla Westergren-Thorsson, Dean of Faculty of Medicine, Lund

University• Professor Karl-Eric Magnusson, Linköping University

National Reference Committee

• Karl-Eric Magnusson (Linköping University)• Anders Malmström (Lund University)• Göran Larsson (University of Gothenburg)• Jens Nielsen (Chalmers University of Technology)• Johan Schnürer (Swedish University of Agricultural Sciences)• Bernt-Eric Uhlin (Umeå University)• Neus Visa (Stockholm University)• Henrik Grönberg (Karolinska Institutet)• Stefan Ståhl (KTH Royal Institute of Technology)• Bengt Westermark (Uppsala University)

SciLifeLab Scientific Advisory Board

• Bertil Andersson, Chair (Nanyang Technological University, Singapore)

• Sören Brunak (Technical University of Denmark, Denmark)

• Jan Ellenberg (EMBL Heidelberg, Germany)

• Yoshihide Hayashizaki (RIKEN Omics Science Center, Japan)

• Sirpa Jalkanen (University of Turku, Finland)

• Janet Jansson (Pacific Northwest National Laboratory, Richland, WA, USA)

• Jonathan Knowles (University of Basel, FIMM University of Helsinki, Switzerland)

• Svante Pääbo (Max Planck Institute for Evolutionary Anthropology, Germany)

• Aviv Regev (Broad Institute, MIT, USA)

• Janet Thornton (EMBL-EBI, UK)

Scientific directors

Executive management

Mathias Uhlén Kerstin Lindblad-Toh

Karin Dahlman-Wright

Strategic management

Gunnar von Heijne Karin Forsberg Nilsson

Stefan Bertilsson

Joakim Lundeberg Helene Andersson Svahn

Mats Nilsson Ulf Landergen

Faculty

Site management Stockholm

Site management Uppsala

Funding

Platforms and facilities

Process for selection

Budget

SciLifeLab projects 2014

2010 2011 2012 2013 20140

500

1000

1500

2000

2500

3000

292

529

941

2235

2632

Year

Pro

jec

ts


Affinity Proteomics167 Bioimaging

20

Bioinformatics782

Chemical Biology Consortium Sweden

37Clinical Diagnostics

43Drug Discovery and

Development29Functional genomics

26

National Genomics Infrastruc-ture728

Structural Biology55

Regional facilities of na-tional interest

745


Regional facilities of national interestNational facilities

Uppsala Uni-versity46%

Stockholm University2%

Karolinska insti-tutet40%

KTH Royal Insti-tute of Technol-

ogy2%

Lund University1%

Swedish Uni-versity of Agri-

cultural Sci-ences

3%

Umeå University1% University of Gothenburg

4%

Linköping University, Linnaeus University, Södertörn University

1%

Uppsala University33%

Stockholm University6%

Karolinska institutet27%

KTH Royal Institute of Technology

7%

Linköping University3%

Linnaeus University1%

Lund University7%

Chalmers University of Technology

1%

Swedish University of Agricultural Sciences

8%

Umeå University4%

University of Gothenburg3%

Mid Sweden University, Södertörn University, Örebro University

<1%


Industry and other Swedish organizations 8%

_x000d_International2%

_x000e_Academic users90%

Distribution of projects by user group


Distribution of projects from organizations outside Swedish academia

Healthcare25%

_x0008_Industry21%

Institute4%

_x000d_Public agency

28%

_x000d_International

23%


Health49%

Environment13%

Basic research5%

Other2%

Unnamed field31%

Distribution of projects within field of science

SciLifeLab publications 2010-2014

2010 2011 2012 2013 20140

100

200

300

400

500

600

65

153

234

294

367

12

29

48

82

68

10

30

32

60

48

7

9

7

22

31

25 ≥ JIP 9 ≤ JIP <256 ≤ JIP <9JIP <6

Year

Pu

bli

ca

tio

ns

221

514

458

321

94

Examples of high impact papers 2014

• Skoglund P, Malmstrom H, Omrak A, et al. 2014. Genomic Diversity and Admixture Differs for Stone-Age Scandinavian Foragers and Farmers. Science 344:747-750.

• Wallberg A, Han F, Wellhagen G, et al. 2014. A worldwide survey of

genome sequence variation provides insight into the evolutionary history of the honeybee Apis mellifera. Nat Genet 2014;46:1081-8.

• Gad H, Koolmeister T, Jemth AS, et al. 2014. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 508:215-221.


• Huber KVM, Salah E, Radic B, et al. 2014. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 508:222-227

• Hammar P, Wallden M, Fange D, et al. 2014. Direct measurement of transcription factor dissociation excludes a simple operator occupancy model for gene regulation. Nature Genet 46:405-

• Caspeta L, Chen Y, Ghiaci P, et al. 2014. Biofuels. Altered sterol composition renders yeast thermotolerant. Science 346:75-78

• Branca RMM, Orre LM, Johansson HJ, et al. 2014. HiRIEF LC-MSMS enables deep proteome coverage and unbiased proteogenomics. Nat Methods 11:59-62.


• Carneiro M, Rubin CJ, Di Palma F, et al. 2014. Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication. Science 2014;345:1074-9.

• -Brawand D, Wagner CE, Li YI, et al. 2014. The genomic substrate for

adaptive radiation in African cichlid fish. Nature 513:375-

• Dumanski J, Rasi, Lönn M, C, et al. 2014. Smoking is associated with mosaic loss of chromosome Y. Science Vol. 347 no. 6217 pp. 81-83

SciLifeLab Fellows

• Magda Bienko from Massachusetts Institute of Technology• Jens Carlsson from Stockholm University• Simon Elsässer from University of Cambridge• Sebastian Deindl from Harvard University• Marc Friedländer from Centre for Genomic Regulation (CRG)• Paul Hudson from U.C Berkeley and KTH Royal Institute of Technology• Tanja Slotte from Uppsala University• Ilaria Testa from Max Planck Institute for Biophysical Chemistry

Strategic recruitments

• Manfred Grabherr from Broad Institute of Harvard and MIT• Carolina Wählby from Broad Institute of Harvard and MIT• Thomas Helleday from the University of Oxford/Stockholm University• Lukas Käll from Stockholm University• Sven Nelander from the University of Gothenburg• Carsten Daub from RIKEN• Thijs Ettema from Uppsala University• Erik Ingelsson from Karolinska Institutet• Mats Nilsson from Uppsala University• Per Arvidsson from AstraZeneca• Petter Brodin from Stanford University• Simone Immler from Uppsala University• Sophie Sanchez from Uppsala University• Cecilia Williams from University of Houston

SciLifeLab courses 2014

Course - Bioinformatics44

Seminar - Bioinformatics3

Course61

Seminar41

Summer School1

Web-based course1

Workshop25

Workshop - Bioinformatics15

Total number of courses, seminars and workshops (number of events focusing on bioinformatics grouped separately) that SciLifeLab has organized or highly contributed to during 2014.


AstraZeneca1

Chalmers University of Technology2

Linköping University20

Linnaeus University2

Lund University5

Länssjukhuset Ryhov1

National Board of Forensic Medicine

1Swedish Museum of Natural

History4

Sahlgrenska University Hospital

3

Swedish University of Agricultural Sciences

37

National Veterinary Institute2

Södertörn University3

Umeå University10

University of Gothebnurg2

Karolinska Institutet32

KTH16

Stockholm University16

Uppsala University73

Participants in bioinformatics courses organized by SciLifeLab during 2014 - University affiliation


Advanced91

Basic21

Doctoral79

Level of education - courses, seminars and workshops that SciLifeLab has organized or highly contributed to.

AIMday & healthcare

Year Activity Description and Results

2011 AIMday Cancer 28 workshops with 80 researchers and 21 company representatives

2012 AIMday Diabetes 16 workshops with 70 researchers and 16 company representatives. Resulted in 3 new research collaborations

2012 AIMday Cancer 26 workshops with 70 researchers and 28 company representatives. One major spin off was the discussion group on real-time register data (see below). Plus a number of other smaller projects

2013 AIMday Diagnostics & Biomarkers

23 workshops with 60 researchers and 24 company representatives. At least two collaborations started.

2013 AIMday CNS Disorders 25 workshops with 59 researchers and 31 company representatives.

2014 AIMday Cancer Combined program with workshops on specific indications as well as companies’ questions.40 academic researchers and 12 company representatives. One collaboration has started.

2014 AIMday Bioimaging In Dec 2014

Outreach activities

• SciLifeLab Day• Workshops• Roadshows

Science & SciLifeLab Prize for young scientists

• global prize, established in 2013 by the scientific journal Science and SciLifeLab

• awarded annually to four young scientists for outstanding life science research for which he/she was awarded a doctoral degree in the previous

Keystone Symposia on Molecular and Cellular Biology

• nonprofit organization headquartered in USA

• 50-60 peer-reviewed conferences in life science world wide every year

• SciLifeLab supports the organization of Keystone Symposia in Stockholm

SciLifeLab – in the media

Nature 484, 171 (12 April, 2012)

Science 328,805 (14 May 2010)

Science 336, 136 (13 April, 2012)

Nature 502, 711-712 (31 October, 2013)

Issues & opportunities

Future remarks

Documents

Vision To be an internationally leading center that develops, uses and provides access to advanced technologies for molecular biosciences with focus on