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4/13/20, 16*58 Virus in Chinese outbreak is closest to one from bats, not snakes | MIT Technology Review Page 1 of 6 https://www.technologyreview.com/2020/01/23/276097/virus-in-chinese-outbreak-is-closest-to-one-from-bats-not-snakes/ Virus in Chinese outbreak is closest to one from bats, not snakes Researchers say the virus spreading through China is in the same family as SARS and closest to one found in bats. Discovery: Today, researchers led by Zheng-Li Shi at the Wuhan Institute for Virology posted a paper describing the virus in detail for the first time, including a picture of the virus infecting cells. The new virus, dubbed nCoV-2019, is in the same family as SARS—a coronavirus that caused global mayhem starting in 2003—and even uses the same receptor to hack into a person’s lung cells, Li’s team found. Outbreak: The current epidemic, which started in mid-December, has already aected more than 500 people, killing several. It may have originated in an animal market in Wuhan, a city of 11 million that Chinese authorities have put under quarantine. Viruses can make the jump from animals to humans, especially when wild animals are kept and sold in food markets, as is alleged to be the case in Wuhan. Gene detectives: It didn’t take long for researchers to grab the genetic sequence of the virus and blast it against big gene databases to see what other germs it is most similar to. Already the virus has been collected and decoded from at least 24 victims in Wuhan, Shenzhen, and other cities. Snake snafu: Another Chinese team this week claimed the virus could have come MAGAZINE The prediction Here is our annu Breakthrough T Plus: why predic how to get bette More issues > This is what it will take to get us back o Gideon Lichfield We’re not going back to normal Gideon Lichfield Sign in We use cookies to offer you a better browsing experience, analyze site traffic, personalize content, and serve targeted advertisements. Read about how we use cookies by clicking "Cookie Information." If you continue to use this site, you consent to our use of cookies. Cookie Information

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Page 1 of 6https://www.technologyreview.com/2020/01/23/276097/virus-in-chinese-outbreak-is-closest-to-one-from-bats-not-snakes/

Biotechnology Jan 23

Virus in Chinese outbreak is closest to one frombats, not snakes

Researchers say the virus spreading through China is in the same family as SARS andclosest to one found in bats.

Discovery: Today, researchers led by Zheng-Li Shi at the Wuhan Institute for Virologyposted a paper describing the virus in detail for the first time, including a picture of thevirus infecting cells.

The new virus, dubbed nCoV-2019, is in the same family as SARS—a coronavirus thatcaused global mayhem starting in 2003—and even uses the same receptor to hackinto a person’s lung cells, Li’s team found.

Outbreak: The current epidemic, which started in mid-December, has alreadyaffected more than 500 people, killing several. It may have originated in an animalmarket in Wuhan, a city of 11 million that Chinese authorities have put underquarantine.

Viruses can make the jump from animals to humans, especially when wild animals arekept and sold in food markets, as is alleged to be the case in Wuhan.

Gene detectives: It didn’t take long for researchers to grab the genetic sequence ofthe virus and blast it against big gene databases to see what other germs it is mostsimilar to. Already the virus has been collected and decoded from at least 24 victims inWuhan, Shenzhen, and other cities.

Snake snafu: Another Chinese team this week claimed the virus could have come

MAGAZINE

The predictions issueHere is our annual list of 10Breakthrough Technologies.Plus: why predictions matter andhow to get better at them.More issues >

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This is what it will take to get us back outsideGideon Lichfield

We’re not going back to normalGideon Lichfield

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from snakes, but that widely reported finding already looks like a mistake. The newanalysis shows its genetic makeup is 96% identical to that of a coronavirus found inbats. “I would be very surprised if this were a snake virus,” says Timothy Sheahan, avirologist at the University of North Carolina. Bats were also the ultimate source ofSARS, scientists believe.

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Author Antonio Regalado

Image Zheng-Li Shi, bioRxiv

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