Vijay B. Samant President and Chief Executive Officer September 2005.

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<ul><li> Slide 1 </li> <li> Vijay B. Samant President and Chief Executive Officer September 2005 </li> <li> Slide 2 </li> <li> Safe Harbor This presentation contains forward-looking statements that are subject to risks and uncertainties that could cause actual results to differ materially from those set forth in the forward- looking statements, including whether any product candidates will be shown to be safe and efficacious in clinical trials and the risks set forth in the companys filings with the Securities and Exchange Commission. Actual results may differ materially from those projected. These forward-looking statements represent the companys judgment as of the date of this presentation. The company disclaims, however, any intent or obligation to update these forward-looking statements. </li> <li> Slide 3 </li> <li> Vical Overview Platform technology Non-viral gene delivery 13 active dev. programs Broad applications Vaccines Cancer Angiogenesis Animal health Key partnerships with pharma partners Broad collaboration with NIH Experienced management team </li> <li> Slide 4 </li> <li> IL-2 EPSolid TumorsPhase 1 Allovectin-7 Melanoma Phase 3 CMV Vaccine Independent Product Pipeline Transplants Phase 2 </li> <li> Slide 5 </li> <li> CMV: The Vical Advantage The opportunity Herpes virus infects 50-85% in the US by age 40 No vaccine available Initial vaccine target: transplant patients Potential follow-on target: at-risk women Advantages of Vicals vaccine approach Ability to harness antibody and T-cell responses Non-infective - a MUST for immunosuppressed patients Proof of efficacy in transplant patients Small clinical trials </li> <li> Slide 6 </li> <li> Unmet Medical Need CMV Disease Burden (U.S.) Transplant recipients Incidence: 2,800 patients/yr Serious effects: 1,600 patients/yr Mortality: 160 deaths/yr Congenital infections Incidence: 40,000 infants/yr Neurological effects: 9,400/yr Mortality: 400 deaths/yr Total U.S. healthcare burden: $4 billion/yr </li> <li> Slide 7 </li> <li> DNA Vaccine for CMV Clinical Status Encouraging Phase 1 data presented in April 2005 Safe and well-tolerated Immunogenic Antibody responses T-cell responses Advancing to Phase 2 in 2005 $4.1 million in NIH grants </li> <li> Slide 8 </li> <li> Phase 2 Proof of Concept Trial HCT Vaccine Strategy HCT Donor HCT Recipient HCT Transplant I. Donor receives 3 injections prior to donation R II. Recipient receives 1 injection prior to transplant and 2 injections after transplant Day -3 to -5, +3-6 weeks and 12 weeks -3 weeks (Week -3, -2, -1) D 160 Subjects </li> <li> Slide 9 </li> <li> IL-2 EP Objective Sustained local expression of IL-2 at therapeutic levels Avoid systemic toxicity associated with protein therapy Phase 1 Trial Design Up to 29 patients Dose escalation: 0.5, 1.5, 5.0 mg Highest dose cohort expanded to 20 patients total Status Trial started July 2005 0.5 mg dose cohort fully enrolled Preliminary data in 2006 </li> <li> Slide 10 </li> <li> Allovectin-7 Phase 2 high-dose trial complete Excellent safety profile 11.8% objective response rate (15 pts of 127 pts) Special Protocol Assessment complete 375 chemo-nave patients randomized 2:1 Primary endpoint: objective response rate @ &gt; 24 wks. Potential partners have advanced to due diligence Unlikely to pursue Phase 3 trial without a partner </li> <li> Slide 11 </li> <li> Pets/Livestock Partnered Product Pipeline VEGF-2Coronary Artery Disease (CAD) FGF-1 I.D./Cancer Peripheral Artery Disease (PAD) Phase 2 Phase 2B SalmonI.D. Approved Research Field Trials Ebola HIV WNV Treatment/Prevention Humans Biodefense Phase 1 PreventionSARS Phase 1 HIVTreatment/Prevention Phase 1 I.D. Vaccines Angiogenesis Veterinary NIH Merck NIH Corautus Centelion Merial Aqua Health CAD / PADHGF Phase 1 / Phase 3 AnGes MG </li> <li> Slide 12 </li> <li> Japanese company founded December 1999 Hepatocyte Growth Factor technology from Osaka U. License from Vical May 2005 $1 million + milestones and royalties Phase 3 PAD started 2004 Japan Phase 2 PAD started 2003 USA Phase 1 CAD started 2004 USA </li> <li> Slide 13 </li> <li> Other Angiogenesis Programs Sanofi Phase 2 PAD started 2002 USA and Europe Phase 2 PAD started 2004 USA and Europe $10+ million received (under multiple agreements) Corautus Genetics Phase 2b CAD started 2004 USA </li> <li> Slide 14 </li> <li> NIH Collaborations NIH vaccine development programs HIV Ebola West Nile virus SARS NIH grants CMV Anthrax HSV Influenza Supply of clinical material Access to IP Fully-funded clinical trials </li> <li> Slide 15 </li> <li> DNA Vaccine for HIV Six-plasmid construct Includes genes for envelope and internal proteins Includes genes for three clades Phase 1 complete Data expected 2005-2006 $12 million in new production orders Supplies for large Phase 2 study </li> <li> Slide 16 </li> <li> DNA Vaccine for Ebola Phase 1 started November 2003 First time in man with Ebola vaccine Enrollment in Phase 1 complete 27 volunteers Immunogenicity data 2005 Approval under FDAs Animal Rule Commercialization rights from NIH Project BioShield $350 million allocated for Ebola </li> <li> Slide 17 </li> <li> DNA Vaccine for WNV Highly immunogenic Neutralizing antibodies Premembrane (prM) Envelope (E) Protection in mice and horses Phase 1 started April 2005 Commercialization rights from CDC and NIH </li> <li> Slide 18 </li> <li> NIH Grants VaccineStatusFunding AnthraxPhase 1$7 million CMV Phase 2$4 million Avian influenzaPreclinical$3 million InfluenzaPreclinical</li></ul>


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