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Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon Jeong, Jayme S. Kwak, Shuangni Yang, Robert M. Lavker, Karla J. F. Satchell Infection and Immunity 2014 May vol. 82 (5) p2148-212157

Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

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Schematic illustration of the molecular structure of the interaction between leukotoxin of Aggregatibacter actinomycetemcomitans and the target cell membrane.

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Page 1: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin

Is an Adenylate Cyclase Toxin Essential for Virulence in Mice

Kevin J. Ziolo, Hee-Gon Jeong, Jayme S. Kwak, Shuangni Yang, Robert M. Lavker, Karla J. F. Satchell

Infection and Immunity 2014 May vol. 82 (5) p2148-212157

Page 2: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

RTX b-barrel pore-forming toxin.

Page 3: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Schematic illustration of the molecular structure of the interaction between leukotoxin of Aggregatibacter actinomycetemcomitans and the target cell membrane.

Page 4: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Synthesis of RTX toxins.

Page 5: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

IP6, inositolhexakisphosphate.

Page 6: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Clostridium difficile toxins A and B, glucosylation of Rho.

Page 7: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon
Page 8: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Vibrio cholerae MARTX.

Page 9: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon
Page 10: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon
Page 11: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Ziolo Kevin et al. (2014) Infect. Immun. Fig.1

Page 12: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Ziolo Kevin et al. (2014) Infect. Immun. Fig.2

Page 13: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Ziolo Kevin et al. (2014) Infect. Immun. Fig.3ab

Page 14: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Ziolo Kevin et al. (2014) Infect. Immun. Fig.3c

Page 15: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

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Page 16: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Ziolo Kevin et al. (2014) Infect. Immun. Fig.4a

Page 17: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Ziolo Kevin et al. (2014) Infect. Immun. Fig.5a

Page 18: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Ziolo Kevin et al. (2014) Infect. Immun. Fig. 5b

Page 19: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Ziolo Kevin et al. (2014) Infect. Immun. Fig.5c

Page 20: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Ziol

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Page 21: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

Ziolo Kevin et al. (2014) Infect. Immun. Fig.6c

Page 22: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon
Page 23: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon
Page 24: Vibrio vulnificus Biotype 3 Multifunctional Autoprocessing RTX Toxin Is an Adenylate Cyclase Toxin Essential for Virulence in Mice Kevin J. Ziolo, Hee-Gon

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