®

VIBRANCE® – A Novel Seedcare Compound for Root Health

Dr. Christian Schlatter, Global Seedcare business manager

Dr. Ronald Zeun, Teamleader Seedcare Fungicides

AGENDA

• Root Health and VIBRANCE

• VIBRANCE technical positioning

• Market demand creation and worldwide launch plans

Root Health: untapped potential for better crop productivity

• New and challenging research area; still a lot to discover

• New industry practices further increase prevalence of soil-borne pathogens and pests

• Imperative to take a holistic view of the root space

• Enhanced capability to resist to biotic and abiotic stresses

The foundations for higher, more consistent yields

Threats to Root Health: It’s a complex underground world!

• Soilborne pathogens. Rhizoctonia, Pythium, Fusarium, etc.

• Underground insects. Wireworms, white grubs, corn rootworms, elasmopalpus, fleabeetle, shootfly, etc.

• Nematodes. Feed on roots, weaken plant resistance to stresses and secondary infections

• Abiotic stresses. Drought, cold, lack of nutrients

Key targets for new compound

Discovering the first Root Health compound has been quite a journey…

Launching new molecule...• > 8 years of research (2003...2011)• > $200m R&D investment• Only 1/100,000 molecule makes

it to the market

Profiling

Launch

Evaluation

Discovery

100’000

5’000

1

30

VIBRANCE® Novel Compound for Root Health

Higher crop performance, right from the start

• SDHI next-generation fungicides; broad spectrum

• Root biostimulant effect; photosynthesis efficiency

• RootingPower: stronger & healthier roots

• Enhanced biotic/abiotic stress management –foundation for higher, more consistent yield

Root Health key to Crop Productivity

... visible differences on the fieldBetter roots results in...

market standard

AGENDA

• Root Health and VIBRANCE

• VIBRANCE technical positioning

• Market demand creation and worldwide launch plans

VIBRANCE® belong to ‘disease control’ and ‘ASM/CE’ categories

• Broad industry interest in complex II inhibition MoAto cover the evolving market needs

• Syngenta at the forefront of SDHI research with several new molecules in early launch phase

SDHI MoA* will play a key rolein fungicides over the next 10 years

1990s 2000s 2010s

IsopyrazamSolatenol

… and more in the development pipeline

Triazoles

Strobilurins

SDHIs

* Mode of Action

SDHIs complex II inhibition MoA

Soil movement of radiolabelled VIBRANCE(Sandy soil or 50% organic matter soil)

High

Radioactivity concentration

Low

Sandy soil High organic matter soil

Location of Vibrance radiolabel

1 watering event

10 watering events

Long-lasting soil protection under a broad rangeof conditions

Seed borne fungi Activity Foliar & soil borne fungi Activity

Ustilago nuda Septoria nodorum*

Tilletia caries Puccinia recondita*

Monographella nivalis Erysiphe graminis*

Pyrenophora graminea Rhizoctonia solani

Cochliobolus sativus Typhula incarnata

Fusarium spp. Gäumannomyces graminis

In vivo Spectrum of VIBRANCE on Cereals

excellent good some effect inactive

* @ rate of 10g/100kg

Seed - & soil borne fungi Activity Foliar & soil borne fungi Activity

Rhizoctonia spp. - many crops Sphacelotheca - corn

Sclerotium spp. - peanut, SB Phakopsora - soya

Phoma spp. - SB, canola Helminthosporium - rice

Macrophomina - Soya H. solani - potato

Fusarium spp. - many crops Colletotrichum - onion

In vivo Spectrum of VIBRANCE on other Crops

excellent good some effect inactive

Rhizoctonia as a pathogen

• Rhizoctonia is known as an important pathogen in many field crops, including cereals,corn, soy beans, rice, potato and sugar beet. Crop rotation may not help to decrease the inoculum in the soil

• Infection leads to nutrient and water stress of the crop• It is found world-wide and across different soil types, upper 10-15 cm• Cold soils, poor nutrition, compacted soils are favourable for the disease • Rhizoctonia is causing stem and root rot, pre and post emergence damping-off and foliar blight• Best known are Rhizoctonia solani and Rhizoctonia cerealis, both leading to heavy crop

damages

Rhizoctonia solani / corn: field damage

Rhizoctonia solani / corn: stem base symptoms

Rhizoctonia solani / corn: root symptoms

Vibrance Untreated

Vibrance, novel Seedcare compound with outstanding activity against Rhizoctonia solani on corn

Inoculated with Rhizoctonia solani

• Rhizotrone study at the Seed Care Institute Stein

• Wheat cv. Arina

• Field soil inoculated with Rhizoctonia cerealis

• Growth conditions 10°C, 12h light

• Picture taken 78 DAP

• Positive impact of Vibrance Gold onemergence, shoot and root growth

Vibrance Gold UTC

Vibrance, novel Seedcare compound with outstanding activity against Rhizoctonia cerealis on wheat

Activity of Vibrance againstRhizoctonia solani on corn

0

20

40

60

80

100

Kontrolle Nichtinokuliert

Kontrolle Inokuliert MAXIM XL 12,5ML/Unit

SEDAXANE 1.5gAI/Unit

MAXIM XL +SEDAXANE

% A

ctiv

ity

Ø of 3 field trials in D and PL 2013, 42-64 DAS

Disease Incidence

Efficacy of Vibrance Gold against Monographella nivalisField Trial Czech Republic (2012 broad acre conditions)

UNTREATED VIBRANCE GOLD

Pest incidence: 46%

60

70

80

90

100

Lamador Kinto Duo Vibrance Gold

% Efficacy

Efficacy of Vibrance Gold againstMonographella nivalisField Trial Czech Republic (2012 broad acre conditions)

Competitor 1 Competitor 2

0 20 40 60 80 100

VM(0,4 l/dt)

VIBRANCE CT(0,2 l/dt)

% Activity

Pest incidence: 28% Bonitur: BBCH 23-29Varieties: Holmes, Bartosz, Fridericus, Merlot, Naomie, Horus

Efficacy of Vibrance CT against Typhula incarnata in barley (n=6)

Classification: INTERNAL USE ONLY

VIBRANCE® belong to ‘disease control’ and ‘ASM/CE’ categories

BIOtransfer publication 2012

VIBRANCE demonstrated biostimulant effect on wheat

Isengrainleft: untreated

right: Vibrance (10g SDX/100kg seed)

Inouileft: untreated

right: Vibrance (10g SDX/100kg seed)

40-85% increasein root biomass

under sterile conditions on two wheat varieties(root assessment 30 and 60 DAP)

Vibrance increases photosynthetic efficiencyof wheat grown under drought stress1

0

2

4

6

8

10

12

14

16

18

20

0 500 1000 1500 2000

Phot

osyn

thes

is (µ

mol

CO

2m

-2s-1

)

Photon flux density (µmol m-2 s-1)

untreated

VIBRANCE

VIBRANCE reduces non-photochemical quenching (NPQ)

Induction of genes in photosynthesis pathway

• First time such effect is demonstratedfor a seed treatment compound2

• This proves that VIBRANCE can helpprevent drought stress in wheat at earlystages

• VIBRANCE has biostimulant effecton plant physiology and goesbeyond disease control

1 Source: Nottingham University research, UK, 2014, winter wheat Gallant2 Similar effect was demonstrated for foliar SDHIs e.g. Isopyrazam

Disease control+

ASM / CE

Higher, more consistent yield

Cereals • Argentina

Soybean • Brazil

Corn • USA

AGENDA

• Root Health and VIBRANCE

• VIBRANCE technical positioning

• Market demand creation and worldwide launch plans

VIBRANCE® successful journey leading to >$200m sales 2014

(2014 SYT results www.syngenta.com)

2010: 1st regulatory submission

2011: 1st launch worldwide

2012: USA/CAN launch

VIBRANCE: >$200m sales achieved in 2014

Root Health - VIBRANCE® focuses on the combinationof Biotic and ASM/CE benefits

BioticBroad spectrum Disease Control

«Hard» claims

ASMRoot Stimulation

Photosynthesis efficiency under drough

«Soft» claims

‘The Power is in the Combination’

Execution examples:

Market standard

Higher and more consistent yield

Stronger, healthier roots

Three key pillars for Market Demand Creation

Root Health Leadership• Regional/Global Root Health Forums• Latest Root Health metodologies• Scientific publications

Technical credibility

Engaging A&P campaigning• Innovative visuals tools & campaign,

emotional trailer, ...• Create and support local excitement

Create emotion ‘roots matter’

Increased use of emedia• E.g. LinkedIn, 700 members

New communication channels

Classification: public

Create emotion ‘roots matter’

VIBRANCE® will be launched across all majorcrops and geographies*

Now expanding to new crops and territories!

Classification: PUBLIC

®

VIBRANCE® – Novel Seedcare Compound for Root Health

Thank you!

© 2015 Syngenta, Basel, Switzerland. All rights reserved.Important: Use seed treatment products safely. Always read the label and product information before use. Labels contain important conditions of sale, including limitations of warranty and remedy.VIBRANCE™ is currently only registered for sale and use in Argentina and France. Registrations are pending in other countries throughout the world; please check with your local regulatory authority for further information.VIBRANCE™, the SYNGENTA Logo, the PURPOSE ICON, the ALLIANCE FRAME and the Seedcare Icon are Trademarks of a Syngenta Group Company

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